metaM lac L x
is: HMDB00190
is: CHEBI:16651
type: Species
name: (S)-lactate
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM CE4790 m
has only substance units: false
is: SBO:0000247
boundary condition: false
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:57923
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790

metaM ahcys m
is: C00021
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00939
is: CHEBI:16680
name: S-Adenosyl-L-homocysteine
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_3ae6e4a9_208e_4450_85de_ea99e5ab93b9
is: SBO:0000252
boundary condition: true
is: B4DKS0
is encoded by: hsa:6566
constant: false
initial amount: NaN
name: SLC16A1
initial concentration: NaN
type: Species
has only substance units: false

metaR r2108
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_d8b16d8d_b723_42b2_8996_7f01d5a93617
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55191
boundary condition: true
is: SBO:0000252
type: Species
name: NADSYN1
constant: false
is: Q6IA69

metaR SPODM
is version of: http://identifiers.org/ec-code/1.15.1.1
name: superoxide dismutase
kinetic law: MODEL1310110006#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
is described by: ECO:0000269
modifier: MODEL1310110006#
reversible: false
product: MODEL1310110006#
reactant: MODEL1310110006#
fast: false

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaR FAOXTC142TC122m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

metaR MACACI
type: Reaction
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.5.1.18
is: SBO:0000176
reversible: false
name: maleylacetoacetate isomerase
modifier: MODEL1310110006#
reactant: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110006#_47dbe497_5fde_4f35_bc1f_8ea85d6222b1
boundary condition: true
initial amount: NaN
is encoded by: hsa:5295
name: PIK3R1
constant: false
has only substance units: false
type: Species
is: B3KT19
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_c85b4473_bc3e_40b0_b048_d1fc69f3ebe9
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:55967
is: F8VQS7
initial amount: NaN
initial concentration: NaN
name: NDUFA12

metaR HOCTDECCRNe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
type: Reaction

metaM gal e
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0
constant: false
is: C00124
name: D-Galactose
has only substance units: false
is: HMDB00143
initial amount: NaN
type: Species
is: CHEBI:0

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaR r0726
is version of: http://identifiers.org/ec-code/2.7.1.33
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: true
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110006#
fast: false
is: SBO:0000176
reactant: MODEL1310110006#
type: Reaction
product: MODEL1310110006#

metaR NTD6
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
modifier: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (dAMP)
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_d8d847a4_b1ba_432f_b304_b332e1872708
initial amount: NaN
is encoded by: hsa:6120
constant: false
name: RPE
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: Q96AT9

http://identifiers.org/biomodels.db/MODEL1310110006#_a70c5b39_2aa2_45d3_a117_97757bd3bea1
is encoded by: hsa:23563
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
name: CHST5

metaM tethex3coa c
boundary condition: false
is: HMDB06243
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
name: tetracosahexaenoyl coenzyme A
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C16168
is: http://identifiers.org/pubchem.compound/47205478

metaR r2109
kinetic law: MODEL1310110006#
product: MODEL1310110006#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
is: SBO:0000185

metaR ASCBt
name: L-ascorbate transport via facilitated diffusion
kinetic law: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
type: Reaction
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_1482a05b_7551_445e_92a5_05397d8f2759
initial amount: NaN
constant: false
is encoded by: hsa:1351
is: SBO:0000252
initial concentration: NaN
type: Species
name: COX8A
is: Q53XN1
has only substance units: false
boundary condition: true

metaM dgchol e
has only substance units: false
is: HMDB00637
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: CHEBI:36252
constant: false
boundary condition: false
type: Species
is: SBO:0000247
name: glycochenodeoxycholate
initial concentration: 1.0

metaR M4BTAer
reversible: false
reactant: MODEL1310110006#
name: M4B transamidase, endoplasmic reticulum
fast: false
notes: GENE_ASSOCIATION: (10026.1) and (128869.1) and (8733.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15208306,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD
modifier: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110006#

metaR CHLtm
is described by: ECO:0000000
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
reactant: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
is: SBO:0000185
fast: false
reversible: true
name: choline transport via diffusion (cytosol to mitochondria)

http://identifiers.org/biomodels.db/MODEL1310110006#_b4f7d5aa_22cc_4e84_8300_8a5919e282c1
is: E7EUT4
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:2597
name: GAPDH
initial concentration: NaN

metaM oretn c
notes: FORMULA: C20H27O3 CHARGE: -1 INCHI: InChI=1/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/p-1
initial amount: NaN
name: 4-oxo-retinoic acid
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB01852
constant: false
initial concentration: 1.0
is: CHEBI:35291

metaM ksi deg39 l
constant: false
name: keratan sulfate I, degradation product 39
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00143
notes: FORMULA: C48H81N3O36 CHARGE: 0
is: CHEBI:12936
initial amount: NaN
type: Species
has only substance units: false

metaM CE4793 x
has only substance units: false
notes: FORMULA: C41H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-28,30,34-36,40,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4793
initial concentration: 1.0
boundary condition: false
name: 3-oxo-dihomo-gama-linolenoyl-CoA
initial amount: NaN
is: CHEBI:57923
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_1c7cced4_5109_4ec9_9b10_efb560484579
initial amount: NaN
is: SBO:0000252
name: PRDX3
boundary condition: true
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: E9PH29
is encoded by: hsa:10935

metaR r0614
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: true
type: Reaction
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
reactant: MODEL1310110006#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_7db47def_8ad9_4cc7_bc48_1491ac84d054
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: A6NDW6
name: ALG8
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:79053
constant: false

metaR 2AMACHYD
name: 2-Aminoacrylate hydrolysis
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:500639 NOTES:SAB see PMID 500639: this reaction is spontaneous
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000176

metaR r0081
is: SBO:0000176
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.5.1.12
type: Reaction
modifier: MODEL1310110006#
product: MODEL1310110006#
reversible: true
is described by: ECO:0000000
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
reactant: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:

metaR TRPt
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
reactant: MODEL1310110006#
name: L-tryptophan transport
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_86c641b4_e1cb_4c65_a2c7_1a9ce740eac0
constant: false
is: SBO:0000252
is encoded by: hsa:84129
name: ACAD11
has only substance units: false
is: Q709F0
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_6ee63a45_188c_4e63_acf4_e558bdf93db7
initial concentration: NaN
is encoded by: hsa:5138
is: Q8IW54
has only substance units: false
name: PDE2A
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_87c424a6_9980_45bd_834b_c65ef0a0cb83
has only substance units: false
name: ALG2
constant: false
initial amount: NaN
is encoded by: hsa:85365
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM ksii core2 g
has only substance units: false
type: Species
is: SBO:0000247
name: keratan sulfate II (core 2-linked)
initial amount: NaN
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
boundary condition: false
is: HMDB01644
is: CHEBI:17140
initial concentration: 1.0
constant: false

metaM ala B c
initial amount: NaN
is: HMDB00056
is: CHEBI:16958
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial concentration: 1.0
boundary condition: false
name: beta-alanine
constant: false

metaM 3ohdcoa x
initial amount: NaN
has only substance units: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: 3-oxopalmitoyl-CoA(4-)
constant: false
is: HMDB06402
is: CHEBI:57349

metaR DESAT18 4
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.19.1
reactant: MODEL1310110006#
fast: false
product: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176
reversible: false
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
kinetic law: MODEL1310110006#

metaR RE3245C
kinetic law: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
name: RE3245

metaM hLkynr c
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:17380
name: 3-hydroxy-L-kynurenine
initial amount: NaN
is: HMDB11631
constant: false
boundary condition: false

metaM gal c
initial concentration: 1.0
is: CHEBI:0
type: Species
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0
is: HMDB00143
constant: false
initial amount: NaN
is: SBO:0000247
is: C00124
has only substance units: false
name: D-Galactose

metaR r0728
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
type: Reaction
reversible: true
fast: false

metaR NTD8
reactant: MODEL1310110006#
product: MODEL1310110006#
name: 5'-nucleotidase (dGMP)
kinetic law: MODEL1310110006#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is version of: http://identifiers.org/ec-code/3.1.3.5
modifier: MODEL1310110006#
is: SBO:0000176
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_4b2cb747_47a1_4eee_878c_e0ba27ac9b38
name: ACO1
is: P21399
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:48
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species

metaM dgchol c
constant: false
type: Species
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: SBO:0000247
is: HMDB00637
has only substance units: false
initial amount: NaN
is: CHEBI:36252
initial concentration: 1.0
name: glycochenodeoxycholate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_b98292b6_50ac_4108_8128_499150f662b5
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
name: _22305_1_c
initial concentration: NaN
is encoded by: hsa:22305
type: Species
initial amount: NaN

metaR FAOXTC122TC101m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

metaR RE2649C
is: SBO:0000176
modifier: MODEL1310110006#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
type: Reaction
name: RE2649

metaR FAOXC101m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaM HC02213 c
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: prostaglandin-e3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
is: SBO:0000247
is: CHEBI:28031

http://identifiers.org/biomodels.db/MODEL1310110006#_963e74a5_7326_476e_8b69_94604a798357
is encoded by: hsa:2530
type: Species
name: FUT8
initial amount: NaN
constant: false
is: Q546E0
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaM 7dhf c
constant: false
name: heptaglutamyl folate (DHF)
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB06559
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
type: Species

metaR RTOTALFATPc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal by enterocytes
type: Reaction

metaM od2coa c
is: HMDB06529
boundary condition: false
name: trans-Octadec-2-enoyl-CoA
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: CE2244
type: Species
is: CHEBI:50570
is: C16218
constant: false
has only substance units: false

metaM HC00900 c
is: CHEBI:30860
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
constant: false
name: Methylmalonate
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
has only substance units: false
initial amount: NaN

metaR r0616
type: Reaction
product: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reactant: MODEL1310110006#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110006#
is: SBO:0000176

metaM ala B e
is: CHEBI:16958
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00056
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
initial concentration: 1.0

metaM ksii core2 e
constant: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00211
has only substance units: false
is: CHEBI:17268
name: keratan sulfate II (core 2-linked)
is: SBO:0000247

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaR HXPRT
type: Reaction
modifier: MODEL1310110006#
reactant: MODEL1310110006#
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
kinetic law: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
is: SBO:0000176
is described by: ECO:0000269
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.8

metaR r2104
product: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110006#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_e93c0964_5d9c_4c7b_8a2d_6c8216285da7
constant: false
is encoded by: hsa:6565
has only substance units: false
initial amount: NaN
name: SLC15A2
is: SBO:0000252
is: Q16348
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_8f079a6c_ec45_4734_b20a_f435f92e6b1c
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5728
initial amount: NaN
is: F6KD01
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: PTEN

metaR THFtm
type: Reaction
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110006#

metaR r0083
kinetic law: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
modifier: MODEL1310110006#
type: Reaction
reversible: true
is described by: ECO:0000000
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.1.1.42

metaR NTD1
type: Reaction
modifier: MODEL1310110006#
fast: false
is: SBO:0000176
name: 5'-nucleotidase (dUMP)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110006#
reversible: false
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_2f79f585_5396_4aca_b794_db149a7ec2dd
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:123041
name: SLC24A4
boundary condition: true
is: SBO:0000252

metaR RE1447N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
product: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: RE1447
fast: false

metaR DESAT18 6
name: fatty acyl-CoA desaturase (n-C18:1CoA -> n-C18:2CoA)
reversible: false
type: Reaction
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
fast: false
product: MODEL1310110006#
reactant: MODEL1310110006#

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_04167b1f_688a_4ec6_9ab6_6ac578a8fb38
is encoded by: hsa:80271
initial amount: NaN
type: Species
constant: false
name: ITPKC
is: Q96DU7
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM cmpacna c
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
is: CHEBI:57812
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
type: Species
initial concentration: 1.0

metaR APOCFm
reversible: false
product: MODEL1310110006#
is: SBO:0000176
name: Apocarboxylase formation, mitochondrial
fast: false
type: Reaction
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism

metaM octe5coa x
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
name: 5-octenoylcoa
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966

metaM 3mop e
is: HMDB00491
initial amount: NaN
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
is: CHEBI:28654
type: Species
boundary condition: false
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0

metaR 5MTHFt2le
fast: false
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
kinetic law: MODEL1310110006#
is: SBO:0000185
type: Reaction
name: 5-methyltetrahydrofolate transport via anion exchange
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaM pan4p c
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C01134
constant: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: HMDB01416
type: Species
is: CHEBI:47942
name: Pantetheine 4'-phosphate

metaR EX retinol cis 11 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cis-11-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_257921e1_69d7_43e7_aae7_c5ecaee143d2
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: HMGCS1
is encoded by: hsa:3157
has only substance units: false
type: Species

metaR r2105
modifier: MODEL1310110006#
is: SBO:0000185
kinetic law: MODEL1310110006#
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110006#
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_acgalfucgalacglcgal14acglcgalgluside_hs_g
is: CHEBI:61648
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C72H125N4O41FULLRCO CHARGE: 0
initial amount: NaN

metaR r0084
is: SBO:0000176
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
fast: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110006#
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.1.1.42
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#

metaM hdd2coa c
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: CHEBI:61526
constant: false
initial concentration: 1.0
name: trans-Hexadec-2-enoyl-CoA
boundary condition: false
initial amount: NaN
is: C05272
is: HMDB03945
has only substance units: false
is: SBO:0000247

metaR RE1447M
kinetic law: MODEL1310110006#
reversible: true
fast: false
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
reactant: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110006#
name: RE1447

http://identifiers.org/biomodels.db/MODEL1310110006#_f204f97b_a54d_4477_9e6c_8a8ff9b32f66
constant: false
has only substance units: false
type: Species
is encoded by: hsa:AI091231
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: _AI091231_1_c
initial amount: NaN

metaR G14T14g
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110006#
kinetic law: MODEL1310110006#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
reactant: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaM HC02213 e
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial concentration: 1.0
has only substance units: false
name: prostaglandin-e3
is: CHEBI:28031

metaR NODe
is described by: ECO:0000134
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110006#
fast: false
product: MODEL1310110006#
type: Reaction
name: NODe
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110006#_0b446d33_f58a_4b8b_9924_ff889ee47dd7
constant: false
is: SBO:0000252
is: B3KWF4
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:63917
name: GALNT11
initial amount: NaN

metaR FAOXC165C164m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_4e6194c4_b92a_46d5_9329_210b9088dfed
boundary condition: true
constant: false
initial concentration: NaN
name: HAS3
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3038
is: Q96RV2

metaR NTD3
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: 5'-nucleotidase (dCMP)
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
modifier: MODEL1310110006#
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110006#
type: Reaction
reversible: false

metaR DESAT22 1p
product: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110006#
type: Reaction
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
reversible: false
kinetic law: MODEL1310110006#
is described by: ECO:0000000

metaR r1177
reversible: false
name: EC:3.1.1.13
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
reactant: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110006#

metaR r2106
modifier: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r0085
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
reactant: MODEL1310110006#
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
modifier: MODEL1310110006#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
product: MODEL1310110006#
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_9fce31a4_8ef8_4df3_9385_0e68c1920093
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:23632
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is: A8K3J4
name: CA14

metaR EX galgalgalthcrm hs LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer (homo sapiens) exchange
type: Reaction

metaM 3mop c
is: HMDB00491
initial amount: NaN
name: 3-methyl-2-oxopentanoate
boundary condition: false
is: CHEBI:28654
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671

http://identifiers.org/biomodels.db/MODEL1310110006#_74c46483_c4f7_4315_a89f_a93b4ebdcfee
is: P09622
type: Species
is encoded by: hsa:1738
boundary condition: true
has only substance units: false
name: DLD
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_643b53ca_2441_40ca_b1a5_b14ee62e1e28
initial concentration: NaN
constant: false
initial amount: NaN
name: CA12
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:771
is: SBO:0000252

metaM pan4p e
initial amount: NaN
name: Pantetheine 4'-phosphate
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: C01134
is: HMDB01416
type: Species
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: CHEBI:47942
is: SBO:0000247

metaR r2107
is: SBO:0000185
kinetic law: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false
product: MODEL1310110006#

metaR UGLCNACtg
product: MODEL1310110006#
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
reactant: MODEL1310110006#
is described by: ECO:0000269
fast: false
name: UDP-GlcNAc Golgi transport via CMP antiport
type: Reaction
is: SBO:0000185
reversible: true

metaR r0086
is version of: http://identifiers.org/ec-code/3.5.1.3
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
fast: false
product: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
is: SBO:0000176
reactant: MODEL1310110006#
modifier: MODEL1310110006#

metaR C141CPT1
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecenoylcarnitine
type: Reaction

metaR TXA2te
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ
name: thromboxane A2 transport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110006#
product: MODEL1310110006#

metaR NTD5
product: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
name: 5'-nucleotidase (dTMP)
is described by: ECO:0000134
is: SBO:0000176
type: Reaction

metaM ksi deg4 l
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
initial concentration: 1.0
is: CHEBI:57737
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
name: keratan sulfate I, degradation product 4
is: HMDB00868
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_1163e306_a116_43d9_b3da_58a081d4f017
constant: false
is encoded by: hsa:5167
type: Species
is: P22413
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ENPP1

metaR RETI3
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 4 AUTHORS: PMID:11606944 NOTES:IT
is described by: ECO:0000000
kinetic law: MODEL1310110006#
type: Reaction
is: SBO:0000176
product: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
fast: false
name: retinol isomerase (13-cis)

http://identifiers.org/biomodels.db/MODEL1310110006#_9c9ec56e_3fd7_4eb9_93d9_50e03e92b1b3
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q53TV9
is: SBO:0000252
is encoded by: hsa:6120
constant: false
name: RPE
type: Species
boundary condition: true

metaM HC02202 e
has only substance units: false
is: CHEBI:57398
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
boundary condition: false
name: prostaglandin A1(1-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_8a1d7a33_7733_46ed_acd0_e24a2ac7e57f
has only substance units: false
constant: false
is encoded by: hsa:4967
initial concentration: NaN
is: B4E3E9
type: Species
is: SBO:0000252
boundary condition: true
name: OGDH
initial amount: NaN

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaM 2octdectecoa x
boundary condition: false
is: SBO:0000247
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
has only substance units: false
name: 2,6,9,12-octadecatetraenoylcoa
type: Species
is: http://identifiers.org/pubchem.compound/5280355
constant: false
initial amount: NaN
initial concentration: 1.0

metaM cmpacna g
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:57812
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)

metaM ocdececrn m
is: SBO:0000247
boundary condition: false
name: 11-octadecenoyl carnitine
type: Species
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0
is: HMDB06351
initial concentration: 1.0
has only substance units: false
constant: false

metaR r1597
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
product: MODEL1310110006#
is: SBO:0000185
reactant: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110006#_de9d3675_f898_4471_bafd_fffbc264cc4f
name: ST3GAL5
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8869
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: Q9UNP4

metaR NRVNCt
kinetic law: MODEL1310110006#
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110006#
fast: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
is: SBO:0000185

metaR RETH2e
type: Reaction
reactant: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
name: retinyl ester hydrolase (11-cis), extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
product: MODEL1310110006#
is described by: ECO:0000000
reversible: false

metaM nadp c
is: HMDB00217
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
is: SBO:0000247
type: Species
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:58349
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_bbae9c0e_fcbf_4848_9c35_6bfe195f14b1
initial concentration: NaN
name: _LOC374569_1_e
is encoded by: hsa:LOC374569
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_d669a5b7_1c47_4443_8636_8321ed6d3dec
name: ECH1
is encoded by: hsa:1891
is: SBO:0000252
constant: false
is: Q13011
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN

metaR FUMTSULtm
type: Reaction
kinetic law: MODEL1310110006#
name: Fumarate:thiosulfate antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
is: SBO:0000185
product: MODEL1310110006#
fast: false
modifier: MODEL1310110006#
is described by: ECO:0000269
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_16f6e18d_bae2_4d8b_8b56_7f617acd53fb
is: SBO:0000252
is encoded by: hsa:6536
is: B7Z3W8
initial concentration: NaN
name: SLC6A9
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false

metaR HDCEAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110006#
fast: false
reversible: true
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: fatty acid transport via diffusion

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR DCK2n
fast: false
reversible: true
is described by: ECO:0000269
name: Deoxycytidine kinase, nuclear (UTP)
is version of: http://identifiers.org/ec-code/2.7.1.74
product: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)

metaR r1596
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#

metaM sucr e
constant: false
name: Sucrose
is: SBO:0000247
is: CHEBI:17992
is: C00089
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00258
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089

metaM nm2masn g
is: SBO:0000247
initial amount: NaN
constant: false
is: C05884
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C42H70N3O30X CHARGE: 0
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
type: Species
has only substance units: false

metaR r1467
type: Reaction
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000185
name: Postulated transport reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110006#

metaR OCTAt
fast: false
is: SBO:0000185
product: MODEL1310110006#
kinetic law: MODEL1310110006#
name: Octanoate transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
reactant: MODEL1310110006#
reversible: true
is described by: ECO:0000000
type: Reaction

metaR TCYNTtm
type: Reaction
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
product: MODEL1310110006#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
name: Thiocyanate transport via diffusion (mitochondrial)
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110006#_f998b4b5_c47c_4ff5_8c68_892d5919c732
is: SBO:0000252
has only substance units: false
is: Q13454
name: TUSC3
type: Species
constant: false
is encoded by: hsa:7991
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR NDPK7n
fast: false
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110006#
is: SBO:0000176
reversible: true

metaR FAOXC102C101x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

metaR FACOAL2042
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110006#
is: SBO:0000176
reversible: true
name: fatty-acid--CoA ligase
fast: false
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
type: Reaction

metaR C142OHe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:2-OH
type: Reaction

metaR AGTim
is described by: ECO:0000269
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
kinetic law: MODEL1310110006#
reversible: false
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.44
modifier: MODEL1310110006#

metaR r0720
fast: false
type: Reaction
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_6dec4142_d88c_4cb6_b675_00afd5b21855
name: NME1
boundary condition: true
initial amount: NaN
type: Species
is: P15531
is encoded by: hsa:4830
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

metaR r1599
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM 7dhf m
boundary condition: false
name: heptaglutamyl folate (DHF)
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
has only substance units: false
type: Species
is: HMDB06559
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_02678fec_2393_4db2_9a2a_d76cab121f98
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: E9KL48
name: GLUD1
initial concentration: NaN
constant: false
is encoded by: hsa:2746

metaR NAGLCAly
reversible: false
reactant: MODEL1310110006#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD
is: SBO:0000176
name: N-acetylglucosaminidase, lysosomal
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000

metaR ADCim
fast: false
name: Acetoacetate decarboxylation (irreversible), mitochondrial
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
reactant: MODEL1310110006#
type: Reaction

metaR FACOAL150
fast: false
name: fatty-acid--CoA ligase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
modifier: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR GLCURtly
reactant: MODEL1310110006#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
is: SBO:0000185
name: glucuronate transport into lysososme
kinetic law: MODEL1310110006#
is described by: ECO:0000269
product: MODEL1310110006#
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_90d5f520_dd81_40e5_bbde_12356f21610e
boundary condition: true
is encoded by: hsa:6470
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SHMT1
constant: false
type: Species
initial amount: NaN

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaR PRISTCOAtcx
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_401abaa6_f90c_4337_8917_1dea88a8aa54
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
name: SLC5A5
is encoded by: hsa:6528
initial amount: NaN
initial concentration: NaN
is: Q92911
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_bcfd4f41_944e_43ef_93fa_f202f3099859
is: B4E0V8
is encoded by: hsa:3034
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
name: HAL

metaM 7dhf l
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
constant: false
initial amount: NaN
is: HMDB06559
boundary condition: false
name: heptaglutamyl folate (DHF)
initial concentration: 1.0

metaR r1598
is: SBO:0000185
kinetic law: MODEL1310110006#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_3b55990a_6dcf_4071_b152_16c2d6742111
is: SBO:0000252
is: Q7Z4L0
constant: false
name: COX8C
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:341947
initial amount: NaN
has only substance units: false

metaM CE2435 m
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
boundary condition: false
is: CHEBI:57795
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: trans,cis-deca-2,4-dienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110006#_d9047550_ae71_413d_8d22_7ebf7a34f790
name: PKLR
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:5313
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR B3GNT312g
product: MODEL1310110006#
modifier: MODEL1310110006#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is described by: ECO:0000254
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction

metaR SFGTH
kinetic law: MODEL1310110006#
name: S-Formylglutathione hydralase
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
modifier: MODEL1310110006#
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.2.12
is described by: ECO:0000269
reversible: true
product: MODEL1310110006#
type: Reaction

metaR HEXDCRNe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_9ab26adc_843f_4acb_9389_eb93fc340309
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: PDE8A
is: H0YMZ7
has only substance units: false
constant: false
is encoded by: hsa:5151
is: SBO:0000252
type: Species

metaM 3ohdcoa m
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 3-oxopalmitoyl-CoA(4-)
constant: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
is: CHEBI:57349
boundary condition: false
has only substance units: false
is: HMDB06402
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_4284419b_bcb0_48cb_af9b_6496341f5bbd
boundary condition: true
is encoded by: hsa:6580
is: O15245
type: Species
has only substance units: false
is: SBO:0000252
name: SLC22A1
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_33f7542f_2370_4617_aee0_d0f954202e81
initial amount: NaN
name: ETFA
boundary condition: true
type: Species
is encoded by: hsa:2108
has only substance units: false
is: P13804
constant: false
is: SBO:0000252
initial concentration: NaN

metaR GRTTx
reversible: false
kinetic law: MODEL1310110006#
type: Reaction
fast: false
name: geranyltranstransferase
is: SBO:0000176
modifier: MODEL1310110006#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.5.1.1
reactant: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ

metaR r1464
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
reversible: true
product: MODEL1310110006#
is described by: ECO:0000000
name: Active transport

http://identifiers.org/biomodels.db/MODEL1310110006#_a1ef07c8_efd3_416e_a912_4323ce3f8005
name: HK1
is: Q59FD4
is encoded by: hsa:3098
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false

metaR AIRCr
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110006#
name: phosphoribosylaminoimidazole carboxylase
reactant: MODEL1310110006#
fast: false
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110006#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/6.3.2.6

http://identifiers.org/biomodels.db/MODEL1310110006#_24f56a1d_89f5_4f32_ac24_ca649e300b71
is: SBO:0000252
initial concentration: NaN
name: PIGP
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is encoded by: hsa:51227

http://identifiers.org/biomodels.db/MODEL1310110006#_f0fbb441_0933_4db5_b971_3d6126e8cfac
name: INPP5D
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is: Q92835
initial amount: NaN
is encoded by: hsa:3635

metaR r0722
fast: false
is version of: http://identifiers.org/ec-code/4.2.3.12
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110006#

metaM tetdece1crn e
notes: FORMULA: C21H39NO4 CHARGE: 0
initial amount: NaN
type: Species
name: tetradecenoyl carnitine
constant: false
is: HMDB02014
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

metaM 7dhf e
type: Species
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
constant: false
is: HMDB06559
boundary condition: false
has only substance units: false
initial amount: NaN
name: heptaglutamyl folate (DHF)
initial concentration: 1.0
is: SBO:0000247

metaM 3octdeccrn e
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: 3-hydroxyoctadecanoyl carnitine
constant: false
is: HMDB13336
is: SBO:0000247
notes: FORMULA: C25H49NO5 CHARGE: 0
type: Species
initial amount: NaN

metaR FUT910g
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
modifier: MODEL1310110006#
reactant: MODEL1310110006#
product: MODEL1310110006#
reversible: false
fast: false
is: SBO:0000176
type: Reaction
name: Alpha-(1,3)-fucosyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.152
is described by: ECO:0000269

metaR r1318
reactant: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
name: Transport reaction
fast: false
type: Reaction
is: SBO:0000185

metaR DNDPt44m
type: Reaction
name: dTTP transport via ATP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reversible: false
product: MODEL1310110006#
fast: false
is: SBO:0000185

metaM 3docopencoa m
type: Species
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
name: 3,7,10,13,16-docosapentenoylcoa
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790

metaR DM atp c
is: SBO:0000176
product: MODEL1310110006#
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110006#
type: Reaction
name: DM_atp(c)
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110006#

metaR FADtx
type: Reaction
name: FAD transporter, peroxisomal
reactant: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
kinetic law: MODEL1310110006#
fast: false

metaR r0724
product: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110006#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
modifier: MODEL1310110006#

metaR THYMt
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110006#
is: SBO:0000185
name: thymine reversible transport via facilated diffusion
type: Reaction
product: MODEL1310110006#
reactant: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT

metaM HC02202 c
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false
is: CHEBI:57398
initial amount: NaN
initial concentration: 1.0
name: prostaglandin A1(1-)
is: SBO:0000247
boundary condition: false
constant: false

metaR r1466
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110006#
reversible: true
name: EC:2.3.1.86
kinetic law: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:

metaM CE2433 m
is: CHEBI:57795
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
initial amount: NaN
type: Species
boundary condition: false

metaR FAOXC164m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_e1d3c81c_f743_4432_ab74_811e942e64bd
is: Q7GXZ8
is: SBO:0000252
constant: false
name: COX2
type: Species
is encoded by: hsa:4513
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_e9df7abc_56eb_4199_81f1_0c4640b7c5b0
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AI291895
has only substance units: false
type: Species
initial concentration: NaN
name: _AI291895_1_c
constant: false

metaM glc D r
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:4167
is: HMDB00122
name: D-glucose
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

http://identifiers.org/biomodels.db/MODEL1310110006#_de1fd749_34e9_4e66_83c2_90b5fcfa1af3
initial concentration: NaN
name: PLCB4
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is: E2QRH8
is encoded by: hsa:5332

metaR C3STDH1r
type: Reaction
kinetic law: MODEL1310110006#
reversible: false
name: C-3 sterol dehydrogenase (4-methylzymosterol)
fast: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER version NJ
is version of: http://identifiers.org/ec-code/1.1.1.170
modifier: MODEL1310110006#
is: SBO:0000176
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134

metaR EX nrvnc LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nervonic acid exchange
type: Reaction

metaM nac c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01488
type: Species
is: C00253
notes: FORMULA: C6H4NO2 CHARGE: -1
is: CHEBI:0
is: SBO:0000247
constant: false
boundary condition: false
name: Nicotinate

metaR GGT6
kinetic law: MODEL1310110006#
type: Reaction
name: Gamma-glutamyltransferase
product: MODEL1310110006#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ

http://identifiers.org/biomodels.db/MODEL1310110006#_2bd3ec03_b747_429e_a080_eff224067ce4
type: Species
is: SBO:0000252
name: PIP4K2C
boundary condition: true
is: B3KQV3
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:79837

metaM 3octdeccrn c
boundary condition: false
initial amount: NaN
constant: false
is: HMDB13336
notes: FORMULA: C25H49NO5 CHARGE: 0
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
name: 3-hydroxyoctadecanoyl carnitine

metaM octe5coa m
has only substance units: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
constant: false
type: Species
name: 5-octenoylcoa
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_9c0481b1_207f_4c88_a13e_27b89a1e18a8
type: Species
initial amount: NaN
constant: false
name: B3GNT6
is encoded by: hsa:192134
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: A8K9Q8

metaR NMNATr
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
name: nicotinamide-nucleotide adenylyltransferase
is described by: ECO:0000269
product: MODEL1310110006#
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_747977b7_81d7_4403_a4a1_c3890a5938e0
is: Q7Z3X3
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2799
type: Species
name: GNS

metaR S2TASE1ly
fast: false
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.6.13
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
type: Reaction
reactant: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000176
name: iduronate-2-sulfatase, lysosomal
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110006#_da76f4dc_a090_4c1e_8a84_40db27fd0cf4
type: Species
is encoded by: hsa:493
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ATP2B4
is: P23634

metaR GGH 6DHFe
product: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (6DHF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

metaR NDP8ex
kinetic law: MODEL1310110006#
product: MODEL1310110006#
modifier: MODEL1310110006#
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
reversible: false
name: nucleoside-diphosphatase (UTP), extracellular
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
fast: false
is described by: ECO:0000269
type: Reaction

metaR FAOXC164C163x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

metaM cmpacna n
has only substance units: false
is: HMDB01176
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57812
boundary condition: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
constant: false
name: CMP-N-acetyl-beta-neuraminate(2-)
initial concentration: 1.0

metaR L LACDcm
product: MODEL1310110006#
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110006#
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
modifier: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110006#

metaM fald c
initial amount: NaN
is: HMDB01426
name: formaldehyde
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
boundary condition: false
initial concentration: 1.0
is: CHEBI:16842
constant: false

metaR FAOXC8C6m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

metaR RE3273C
reversible: true
kinetic law: MODEL1310110006#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
modifier: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.4
name: RE3273

metaR FAOXC165C164x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:5-->C16:4)x
type: Reaction

metaR OCD11COACPT1
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR B3GNT11g
is described by: ECO:0000269
kinetic law: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (10678.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
reversible: false
type: Reaction
reactant: MODEL1310110006#
is: SBO:0000176
fast: false
modifier: MODEL1310110006#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR r2401
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110006#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
kinetic law: MODEL1310110006#
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_13e7de83_8bd2_4266_899d_202498125e42
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
name: _7359_1_c
type: Species
initial amount: NaN
is encoded by: hsa:7359
constant: false

metaM ala D c
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:15570
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01310
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
name: D-alanine

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaR S6TASE15ly
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
reactant: MODEL1310110006#
reversible: true
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110006#
product: MODEL1310110006#

metaM sph1p e
initial amount: NaN
has only substance units: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: HMDB01383
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:57939
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120

metaM galacglcgalgbside hs g
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
constant: false
initial amount: NaN
name: Gal-GlcNAc-Gal globoside
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:26174
type: Species

metaR PI34P5K
type: Reaction
reversible: false
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
is: SBO:0000176
kinetic law: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
reactant: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.68

metaM c81crn e
initial amount: NaN
is: SBO:0000247
is: HMDB13324
type: Species
notes: FORMULA: C15H27NO4 CHARGE: 0
has only substance units: false
boundary condition: false
name: octenoyl carnitine
constant: false
initial concentration: 1.0

metaR DTDPtn
reactant: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
name: dTDP nuclear transport

metaR r0839
is version of: http://identifiers.org/ec-code/1.3.1.70
reversible: true
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000185
fast: false
product: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
name: Postulated transport reaction

metaM alpam m
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
initial amount: NaN
is: HMDB06239
has only substance units: false
name: S-aminomethyldihydrolipoamide
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
is: SBO:0000247

metaR DNDPt22m
kinetic law: MODEL1310110006#
type: Reaction
fast: false
modifier: MODEL1310110006#
is: SBO:0000185
reactant: MODEL1310110006#
reversible: false
name: dTDP transport via dUDP antiport
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269

metaR FAOXC163x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

metaM fald e
type: Species
name: formaldehyde
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:16842
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
initial amount: NaN
initial concentration: 1.0
is: HMDB01426

http://identifiers.org/biomodels.db/MODEL1310110006#_d10afdc9_6b3e_473f_85e5_12a67b8999a5
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:84532
is: Q9NUB1
name: ACSS1
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

metaM arg L c
type: Species
constant: false
initial amount: NaN
is: HMDB00517
is: CHEBI:32682
has only substance units: false
name: L-argininium(1+)
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_4617fd96_625e_4984_98d4_490ad629854b
constant: false
initial amount: NaN
name: SLC25A18
boundary condition: true
has only substance units: false
is encoded by: hsa:83733
is: Q9H1K4
initial concentration: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_7608905f_58ea_4de0_bb4d_080fad4cceb7
name: PIGZ
initial concentration: NaN
has only substance units: false
is: Q86VD9
initial amount: NaN
type: Species
is encoded by: hsa:80235
is: SBO:0000252
boundary condition: true
constant: false

metaM tetdece1crn c
type: Species
boundary condition: false
is: SBO:0000247
name: tetradecenoyl carnitine
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB02014
notes: FORMULA: C21H39NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110006#_38739f40_70eb_42b2_b78d_9192e4385a87
is: P10768
name: ESD
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:2098
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR TXA2tr
reversible: true
name: thromboxane A2 intracellular transport
type: Reaction
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ
product: MODEL1310110006#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR S6T17g
is described by: ECO:0000000
product: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110006#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110006#
reversible: false

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaR BALAtmr
name: Beta-alanine reversible mitochondrial transport (diffusion)
reversible: true
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
product: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR PI345P5P
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.56
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
is: SBO:0000176
product: MODEL1310110006#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110006#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_91208f0f_e91b_4b2b_bfc7_b045b827791b
is encoded by: hsa:728441
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: GGT2
type: Species
has only substance units: false
boundary condition: true
constant: false

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_c6d08baa_bef5_4432_a3b7_81f7f487def4
boundary condition: true
is encoded by: hsa:5106
name: PCK2
is: Q16822
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_9c4d4399_8f7f_4f86_9482_4433e07fcac8
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2987
is: Q16774
constant: false
type: Species
name: GUK1

metaR GGH 10FTHF7GLUe
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
modifier: MODEL1310110006#
product: MODEL1310110006#

metaR GALASE18ly
name: beta-galactosidase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
modifier: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18

http://identifiers.org/biomodels.db/MODEL1310110006#_428c0bf7_3751_4142_aa54_3a00012cbf95
initial concentration: NaN
is encoded by: hsa:2592
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: E7ET32
name: GALT

metaM ala D e
is: CHEBI:15570
initial concentration: 1.0
name: D-alanine
initial amount: NaN
is: HMDB01310
boundary condition: false
type: Species
constant: false
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: SBO:0000247

metaM c81crn c
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C15H27NO4 CHARGE: 0
is: HMDB13324
type: Species
boundary condition: false
name: octenoyl carnitine
initial concentration: 1.0

metaM CE0785 m
initial concentration: 1.0
is: CHEBI:57795
initial amount: NaN
type: Species
has only substance units: false
name: cis,cis-myristo-5,8-dienoyl-CoA
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
boundary condition: false
constant: false

metaM HC00695 m
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
name: S-Succinyldihydrolipoamide
initial amount: NaN
type: Species
is: CHEBI:17432
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_f283f1e2_1159_494e_a606_acf0c52afe7a
boundary condition: true
initial amount: NaN
is: SBO:0000297
has part: P48736
is encoded by: hsa:10870
initial concentration: NaN
name: HCST:PIK3CG
has part: Q9UBK5
constant: false
type: Species
has only substance units: false
is encoded by: hsa:5294

metaR r0941
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110006#
kinetic law: MODEL1310110006#
name: Free diffusion
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110006#

metaM hs deg13 l
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:17180
boundary condition: false
initial concentration: 1.0
is: HMDB01352
is: SBO:0000247
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
name: heparan sulfate, degradation product 13

metaR HTDCRNe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

metaR OCTDECCACT
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaM dcsptn1coa c
type: Species
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: C16173
is: HMDB06513
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205483
has only substance units: false

metaM arg L e
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
constant: false
name: L-argininium(1+)
boundary condition: false
is: CHEBI:32682
initial amount: NaN

metaR PIPLC
product: MODEL1310110006#
reversible: false
is described by: ECO:0000000
name: phosphatidylinositol phospholipase C
type: Reaction
modifier: MODEL1310110006#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.4.11

metaM 2obut m
name: 2-oxobutanoate
is: HMDB00005
is: CHEBI:16763
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
type: Species
is: SBO:0000247

metaR CYSSNAT5tc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM cs b deg1 l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
initial amount: NaN
is: HMDB01354
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:57455
boundary condition: false
is: SBO:0000247
notes: FORMULA: C45H67N2O46S3 CHARGE: -5

http://identifiers.org/biomodels.db/MODEL1310110006#_cd72a5de_9c1a_4281_94a9_e5a6ec2cc904
boundary condition: true
name: SLC16A3
is encoded by: hsa:9123
type: Species
is: O15427
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_82836670_fc86_4932_aa9c_c844246613c2
name: HADHB
is: P55084
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:3032

metaR DAGKn hs
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.107
is described by: ECO:0000269
kinetic law: MODEL1310110006#
name: Diacylglycerol phosphate kinase (homo sapiens)
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
fast: false
reversible: true
product: MODEL1310110006#

metaR FAOXC102C101m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

metaR r0940
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reactant: MODEL1310110006#
fast: false
reversible: true
product: MODEL1310110006#
kinetic law: MODEL1310110006#
name: Free diffusion
is: SBO:0000185
is described by: ECO:0000000

metaM ksi deg7 l
is: CHEBI:57455
constant: false
name: keratan sulfate I, degradation product 7
is: SBO:0000247
is: HMDB01354
type: Species
has only substance units: false
notes: FORMULA: C210H337N15O181S10 CHARGE: -10
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM dcacoa m
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: C05274
is: HMDB06404
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: Decanoyl-CoA (n-C10:0CoA)
is: CHEBI:61430

metaR r0835
is version of: http://identifiers.org/ec-code/3.5.4.16
reactant: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110006#
modifier: MODEL1310110006#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
kinetic law: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaM ksi pre15 g
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 15
constant: false
is: SBO:0000247
is: CHEBI:58053
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00175
initial concentration: 1.0
is: C00130

metaM ile L m
is: SBO:0000247
constant: false
is: CHEBI:17191
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial amount: NaN
name: L-isoleucine
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00172

metaM galacglcgalgbside hs c
is: CHEBI:58343
name: Gal-GlcNAc-Gal globoside
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00061
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
constant: false

metaR NDPK6n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
type: Reaction
product: MODEL1310110006#
is described by: ECO:0000304
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110006#
is: SBO:0000176
reactant: MODEL1310110006#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_b9a2a24d_e9fe_413d_ad87_1d4517614c38
type: Species
boundary condition: true
name: FUT1
initial concentration: NaN
is encoded by: hsa:2523
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
is: Q6IZA2

http://identifiers.org/biomodels.db/MODEL1310110006#_acdf300c_87c1_408f_80d1_e5723d0342f1
has only substance units: false
initial amount: NaN
type: Species
is: B7Z6S9
boundary condition: true
constant: false
is encoded by: hsa:2629
is: SBO:0000252
initial concentration: NaN
name: GBA

metaM thf c
has only substance units: false
is: CHEBI:57453
type: Species
name: 5,6,7,8-Tetrahydrofolate
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB01846
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: C00101

http://identifiers.org/biomodels.db/MODEL1310110006#_44e5b5e4_b295_4f00_8d42_c94232022268
initial amount: NaN
is encoded by: hsa:8818
name: DPM2
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM sph1p c
type: Species
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: CHEBI:57939
has only substance units: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial amount: NaN
initial concentration: 1.0
is: HMDB01383
constant: false
is: SBO:0000247
boundary condition: false

metaR THYOXt2
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
name: T4 transport via facilitated diffusion
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110006#
is described by: ECO:0000269
fast: false
product: MODEL1310110006#

metaM hspg e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
initial concentration: 1.0
is: HMDB02259
constant: false
type: Species
name: heparan sulfate proteoglycan
is: CHEBI:32366
initial amount: NaN
boundary condition: false

metaM adrncoa m
boundary condition: false
type: Species
name: adrenyl coenzyme A
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205480
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_fb3acc93_3324_4c08_98c2_2e0d5bfbe9bd
is: Q9NP59
initial concentration: NaN
has only substance units: false
is encoded by: hsa:30061
initial amount: NaN
name: SLC40A1
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaR r0838
fast: false
is: SBO:0000185
modifier: MODEL1310110006#
reactant: MODEL1310110006#
reversible: true
product: MODEL1310110006#
name: Free diffusion
kinetic law: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.4

http://identifiers.org/biomodels.db/MODEL1310110006#_1a300774_454d_422e_a7f8_d5e12c3050c7
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:218
is: P30838
name: ALDH3A1
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252

metaM creat e
boundary condition: false
name: creatine
initial amount: NaN
constant: false
type: Species
is: CHEBI:16919
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: SBO:0000247
is: HMDB00064

metaR SPODMm
is version of: http://identifiers.org/ec-code/1.15.1.1
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
product: MODEL1310110006#
is described by: ECO:0000304
modifier: MODEL1310110006#
type: Reaction
name: superoxide dismutase
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_bd33197d_43f1_4076_8426_851d30c71909
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
name: NDUFA5
boundary condition: true
is encoded by: hsa:4698
has only substance units: false
is: Q16718

metaR THD1m
is version of: http://identifiers.org/ec-code/1.6.1.2
is described by: ECO:0000269
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
is: SBO:0000185
name: NAD(P) transhydrogenase
type: Reaction
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (23530.2) or (23530.1) SUBSYSTEM: NAD metabolism EC Number: 1.6.1.2 Confidence Level: 4 AUTHORS: PMID:12223207,PMID:8647343,PMID:9524818 NOTES:TDV (2-6-2003)
fast: false

metaR FACOAL140i
reactant: MODEL1310110006#
name: fatty-acid--CoA ligase (tetradecanoate)
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
fast: false
product: MODEL1310110006#
is described by: ECO:0000269
kinetic law: MODEL1310110006#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110006#

metaM ksi pre19 g
name: keratan sulfate I biosynthesis, precursor 19
is: CHEBI:58053
is: SBO:0000247
is: HMDB00175
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C00130
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_66ca9c17_ecde_46ac_bec3_98b3c7374277
is encoded by: hsa:47
initial concentration: NaN
initial amount: NaN
name: ACLY
constant: false
is: SBO:0000252
is: P53396
has only substance units: false
type: Species
boundary condition: true

metaR r0942
type: Reaction
reactant: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
reversible: true
is: SBO:0000185
product: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_acf386c4_f813_47a4_81b8_13964bc2d889
type: Species
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: ALDH1A2
initial concentration: NaN
is encoded by: hsa:8854
is: SBO:0000252
is: O94788

metaR CREATt4 2 r
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Creatine transport (sodium symport) (2:1)
reversible: true
kinetic law: MODEL1310110006#
is: SBO:0000185
product: MODEL1310110006#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110006#
reactant: MODEL1310110006#
fast: false

metaM ahcys c
is: C00021
constant: false
boundary condition: false
name: S-Adenosyl-L-homocysteine
is: HMDB00939
is: CHEBI:16680
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial concentration: 1.0
initial amount: NaN

metaM nm4masn g
boundary condition: false
has only substance units: false
initial amount: NaN
is: C05882
is: SBO:0000247
notes: FORMULA: C54H90N3O40X CHARGE: 0
constant: false
type: Species
initial concentration: 1.0
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)

metaM dag hs n
boundary condition: false
type: Species
is: CHEBI:18035
name: diglyceride
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: SBO:0000247
initial concentration: 1.0

metaM galacglcgalgbside hs e
is: CHEBI:0
constant: false
initial amount: NaN
is: C00124
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00143
name: Gal-GlcNAc-Gal globoside
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110006#_74a9aa73_d332_46a8_ade0_c73a8a8962d0
is: SBO:0000252
initial amount: NaN
is: Q9ULD0
boundary condition: true
name: OGDHL
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:55753

http://identifiers.org/biomodels.db/MODEL1310110006#_2e9923ae_95b3_4be6_b286_c670fcfb0d8c
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AW299740
type: Species
constant: false
initial amount: NaN
name: _AW299740_1_m

metaR DCSPTN1t
type: Reaction
name: fatty acid transport via diffusion
is described by: ECO:0000000
product: MODEL1310110006#
is: SBO:0000185
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
fast: false

metaM ksi deg28 l
name: keratan sulfate I, degradation product 28
boundary condition: false
is: SBO:0000247
is: HMDB01354
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57455
constant: false
has only substance units: false
notes: FORMULA: C104H170N7O85S3 CHARGE: -3

metaM pail345p hs c
initial amount: NaN
has only substance units: false
is: CHEBI:57836
type: Species
boundary condition: false
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM creat c
initial amount: NaN
is: CHEBI:16919
constant: false
boundary condition: false
is: HMDB00064
is: SBO:0000247
type: Species
name: creatine
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300

metaR O2t
is described by: ECO:0000000
name: o2 transport (diffusion)
type: Reaction
reactant: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
product: MODEL1310110006#
is: SBO:0000185

metaR r2113
reversible: true
type: Reaction
modifier: MODEL1310110006#
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_1bcbc284_ef0b_4b07_8884_9fb1885a1edb
is encoded by: hsa:10965
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ACOT2
has only substance units: false
is: P49753
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_5523d7e7_308c_4f34_9ba8_7aed815315b8
is encoded by: hsa:4645
name: MYO5B
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
is: Q9H6Y6
is: SBO:0000252

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaR sink c101coa LPAREN c RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C101COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_e9d1645b_0280_44cf_827e_ac57f952db29
boundary condition: true
has only substance units: false
name: ALDH9A1
is encoded by: hsa:223
type: Species
is: P49189
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaR r0944
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
reactant: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
name: Active transport

metaM ahcys e
notes: FORMULA: C14H20N6O5S CHARGE: 0
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:16680
is: HMDB00939
name: S-Adenosyl-L-homocysteine
is: SBO:0000247
constant: false
is: C00021

http://identifiers.org/biomodels.db/MODEL1310110006#_654c8d75_9348_4788_b543_1d5ca17419c6
initial amount: NaN
is encoded by: hsa:3417
name: IDH1
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is: O75874

metaR A4GALTg
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
is version of: http://identifiers.org/ec-code/2.4.1.228
name: Lactosylceramide 4-alpha-galactosyltransferase
product: MODEL1310110006#
modifier: MODEL1310110006#
reactant: MODEL1310110006#
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000176

metaR FAOXC101x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_c801b146_20b1_49b4_bb20_ee8113e305b2
is: Q9UBF8
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: PI4KB
constant: false
is encoded by: hsa:5298
initial concentration: NaN
has only substance units: false

metaR r2112
type: Reaction
product: MODEL1310110006#
modifier: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110006#_02a65f89_0568_42e6_b093_0b1da8f77281
type: Species
boundary condition: true
is encoded by: hsa:251
is: SBO:0000252
initial concentration: NaN
is: P10696
name: ALPPL2
initial amount: NaN
has only substance units: false
constant: false

metaR GGH 6DHFl
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110006#
type: Reaction
fast: false
reversible: false
name: Gamma-glutamyl hydrolase (6DHF), lysosomal
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.4.19.9

http://identifiers.org/biomodels.db/MODEL1310110006#_15b1b5b2_bb8e_4f2a_b65a_1351aa96ee26
type: Species
constant: false
is encoded by: hsa:5198
name: PFAS
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q6P4B4

http://identifiers.org/biomodels.db/MODEL1310110006#_46df3fe4_3630_4304_8e03_964ac4b8f466
name: SYNJ2
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: O15056
type: Species
is: SBO:0000252
is encoded by: hsa:8871
has only substance units: false

metaM gal l
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
type: Species
is: SBO:0000247
is: HMDB00143
name: D-galactose
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110006#_37889d55_5656_4182_82bf_0f0153c77e67
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:137964
is: Q86UL3
is: SBO:0000252
initial concentration: NaN
name: AGPAT6

metaR RE0583C
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
name: RE0583
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
is described by: ECO:0000000

metaM paps g
boundary condition: false
is: HMDB01134
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: CHEBI:58339
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_c48ac503_871f_499f_b5b2_f8dbafa606e3
boundary condition: true
is: P49247
constant: false
type: Species
is encoded by: hsa:22934
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: RPIA

metaR r2408
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110006#
reversible: false
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110006#
product: MODEL1310110006#

metaR r0834
reactant: MODEL1310110006#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
kinetic law: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110006#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.16

metaR PHEACGLNt
is: SBO:0000185
is described by: ECO:0000000
name: PHEACGLN extracellular transport via diffusion
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
kinetic law: MODEL1310110006#
type: Reaction
fast: false
reversible: true
product: MODEL1310110006#

metaR r2115
type: Reaction
reactant: MODEL1310110006#
reversible: true
is: SBO:0000185
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR LEUt5m
kinetic law: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
name: leucine mitochondrial transport
reactant: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
is described by: ECO:0000000
reversible: true

metaM 5fthf m
name: 5-formyltetrahydrofolate(2-)
is: CHEBI:57457
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01562
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
initial amount: NaN

metaR EX udpg LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_a4eee76f_d09b_47f3_832d_3b91c65bc638
is encoded by: hsa:9487
constant: false
name: PIGL
initial amount: NaN
type: Species
is: Q9Y2B2
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_889c3630_446f_495f_9363_499274f44053
has only substance units: false
boundary condition: true
is encoded by: hsa:1347
type: Species
name: COX7A2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: H0UI06
constant: false

metaM dag hs r
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
is: SBO:0000247
boundary condition: false
type: Species
constant: false
name: diglyceride
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:18035

metaM HC01496 m
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
initial amount: NaN
boundary condition: false
is: CHEBI:28095
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: 2-Amino-3-oxoadipate
has only substance units: false

metaR GBSIDEte
product: MODEL1310110006#
type: Reaction
reversible: true
kinetic law: MODEL1310110006#
is: SBO:0000185
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - The goal of this transporter is to get globoside to the EC plasma membrane NJ
name: globoside transport
is described by: ECO:0000000
fast: false

metaM urea m
initial concentration: 1.0
is: CHEBI:16199
is: SBO:0000247
is: HMDB00294
initial amount: NaN
type: Species
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
constant: false
boundary condition: false
name: Urea
has only substance units: false
is: C00086

http://identifiers.org/biomodels.db/MODEL1310110006#_044cbf0d_0df3_40e8_b811_fd0b894c98f1
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
name: ALDH2
has only substance units: false
is encoded by: hsa:217
boundary condition: true
is: P05091

metaR SCP21cx
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR r0946
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110006#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
reversible: true

metaM CE5869 e
is: HMDB02710
boundary condition: false
name: lysyl-proline
notes: FORMULA: C11H22N3O3 CHARGE: 1 INCHI: InChI=1/C11H21N3O3/c12-6-2-1-4-8(13)10(15)14-7-3-5-9(14)11(16)17/h8-9H,1-7,12-13H2,(H,16,17)/p+1/t8-,9-/m1/s1 EHMN_ABBREVIATION: CE5869
is: CHEBI:27485
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_27c0af2c_3fa6_44b8_9cff_9257c4b75a52
is: O75438
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:4707
constant: false
initial concentration: NaN
name: NDUFB1

metaR r2114
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110006#
fast: false
product: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_4b9be44d_921f_4520_842e_052b0b987c86
boundary condition: true
is encoded by: hsa:5279
name: PIGC
initial concentration: NaN
is: Q92535
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species

metaR ATP2ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
type: Reaction
reactant: MODEL1310110006#
product: MODEL1310110006#
fast: false
reversible: true
name: AMP/ATP transporter, endoplasmic reticulum
is described by: ECO:0000000
kinetic law: MODEL1310110006#

metaM glu5sa m
is: C01165
has only substance units: false
is: CHEBI:17232
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: SBO:0000247
constant: false
type: Species
name: L-Glutamate 5-semialdehyde
is: HMDB02104

metaR VALTAm
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
name: valine transaminase, mitochondiral
type: Reaction
reactant: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is described by: ECO:0000269
reversible: true
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_7c6ad12c_0c61_4ae2_a49d_9a08e3ea903c
boundary condition: true
type: Species
name: DPM3
constant: false
is: SBO:0000252
has only substance units: false
is: Q9P2X0
is encoded by: hsa:54344
initial amount: NaN
initial concentration: NaN

metaM adrncoa x
is: http://identifiers.org/pubchem.compound/47205480
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: C16170
name: adrenyl coenzyme A
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_0f053e9b_2068_401c_adda_0cdb7ed0aa85
type: Species
constant: false
name: PIK3R3
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8503
is: Q92569
is: SBO:0000252

metaR PYNP2r
fast: false
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110006#
product: MODEL1310110006#
reversible: true
name: pyrimidine-nucleoside phosphorylase (uracil)
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.2.3
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
type: Reaction

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_3247b683_6a2d_45ce_a29f_d616e9c45c13
initial concentration: NaN
constant: false
is: P04745
is encoded by: hsa:277
type: Species
name: AMY1B
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR GLUt7l
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reversible: false
is: SBO:0000185
name: Glutamate transport, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
fast: false

metaR GBSIDEtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) NJ
is: SBO:0000185
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: globoside intracellular transport
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
reversible: true
fast: false

metaM ksii core2 l
is: HMDB01644
initial amount: NaN
name: keratan sulfate II (core 2-linked)
constant: false
initial concentration: 1.0
is: CHEBI:17140
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
boundary condition: false

metaR UMPK6n
modifier: MODEL1310110006#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
name: UMP kinase (dCTP),nuclear
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: true

metaM nrvnccoa x
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
initial concentration: 1.0
boundary condition: false
name: nervonyl coenzyme A
is: C16532
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM dopasf e
initial concentration: 1.0
name: dopamine 3-O-sulfate
is: CHEBI:37946
type: Species
boundary condition: false
has only substance units: false
constant: false
is: HMDB06275
is: SBO:0000247
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
initial amount: NaN

metaR S2TASE3ly
name: iduronate-2-sulfatase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (3423.2) or (3423.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reversible: false
type: Reaction
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.6.13
is: SBO:0000176
modifier: MODEL1310110006#

metaR MALSO3tm
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
is: SBO:0000185
is described by: ECO:0000269
reversible: true
type: Reaction
product: MODEL1310110006#
name: Malate:sulfite antiport, mitochondrial

metaR FAOXC14C14OHm
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C14OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_b4bd7167_a35f_4bf3_b97f_a2002df8a7e4
is: SBO:0000252
name: RDH10
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: Q8IZV5
has only substance units: false
is encoded by: hsa:157506

http://identifiers.org/biomodels.db/MODEL1310110006#_71d1ea82_c62e_412e_85e6_ff609a54791e
type: Species
initial concentration: NaN
name: _LOC728997_1_c
is encoded by: hsa:LOC728997
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

metaM ile L e
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:17191
boundary condition: false
constant: false
is: HMDB00172
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
name: L-isoleucine
initial amount: NaN

metaM 2obut c
boundary condition: false
is: SBO:0000247
name: 2-Oxobutanoate
is: C00109
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16763
has only substance units: false
is: HMDB00005

metaM arg L m
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false
name: L-argininium(1+)
type: Species
initial concentration: 1.0
constant: false
is: HMDB00517
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:32682

metaR ILEtec
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110006#
fast: false
modifier: MODEL1310110006#
type: Reaction
is: SBO:0000185
name: L-isoleucine transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB

metaM 3mop m
initial amount: NaN
is: HMDB00491
type: Species
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: CHEBI:28654
has only substance units: false
boundary condition: false
name: 3-methyl-2-oxopentanoate
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_29460503_ed53_4930_a551_061cee889b7c
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2348
has only substance units: false
name: FOLR1
initial concentration: NaN
type: Species
initial amount: NaN

metaM xan c
has only substance units: false
name: Xanthine
is: HMDB00292
initial amount: NaN
type: Species
is: CHEBI:17712
is: C00385
constant: false
is: SBO:0000247
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
initial concentration: 1.0
boundary condition: false

metaR MTHFCm
product: MODEL1310110006#
is described by: ECO:0000269
reactant: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.3.4.3
fast: false
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial

metaR SPODMe
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (6649.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:12126755,PMID:3476950,PMID:9228011 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.15.1.1
kinetic law: MODEL1310110006#
fast: false
is described by: ECO:0000269
name: superoxide dismutase, extracellular
reversible: false
modifier: MODEL1310110006#
type: Reaction
is: SBO:0000176

metaM paps c
initial amount: NaN
constant: false
is: HMDB01134
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
is: SBO:0000247
is: CHEBI:58339

http://identifiers.org/biomodels.db/MODEL1310110006#_fafd375a_9bcf_43d7_ab92_be0e70e4c5d3
boundary condition: true
type: Species
is encoded by: hsa:5152
has only substance units: false
initial concentration: NaN
name: PDE9A
is: SBO:0000252
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_e43850ad_1a0f_4ff5_bb53_71d68ea5eea5
constant: false
boundary condition: true
name: _H17063_1_m
has only substance units: false
is encoded by: hsa:H17063
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252

metaM dopasf c
initial amount: NaN
is: CHEBI:37946
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
is: HMDB06275
constant: false
name: dopamine 3-O-sulfate
is: SBO:0000247
initial concentration: 1.0

metaM pacald c
has only substance units: false
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
is: SBO:0000247
is: CHEBI:16424
type: Species
is: HMDB06236
name: phenylacetaldehyde
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false

metaR r2111
type: Reaction
modifier: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true
reactant: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_186e09b0_a534_4e3b_b83c_7a72158cf325
is encoded by: hsa:8611
is: G3XA95
initial amount: NaN
name: PPAP2A
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_75699355_e2ab_47b5_87af_c9e75b006846
name: GPX7
initial amount: NaN
type: Species
is encoded by: hsa:2882
boundary condition: true
constant: false
is: SBO:0000252
is: Q96SL4
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_dea5471e_fedf_45a9_a378_d2f56d02c5a4
is: P20674
initial amount: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
name: COX5A
is encoded by: hsa:9377
is: SBO:0000252
initial concentration: NaN

metaR r2404
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110006#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110006#

metaR r0830
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
product: MODEL1310110006#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.16
is: SBO:0000185
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_453630af_f842_44a4_972e_489264fc3265
is: SBO:0000252
has only substance units: false
is encoded by: hsa:124583
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: CANT1
type: Species
is: Q8WVQ1

metaR PMTCOAtx
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110006#
name: fatty acid intracellular transport
fast: false
reversible: true
type: Reaction
is: SBO:0000185

metaR FALDH
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110006#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
reversible: true
product: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176
name: formaldehyde dehydrogenase

metaM HC02217 c
type: Species
has only substance units: false
name: prostaglandin-g2
is: CHEBI:27647
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
constant: false
initial amount: NaN
initial concentration: 1.0

metaM pac c
has only substance units: false
is: HMDB00209
name: phenylacetate
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:18401
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086

metaM ile L c
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00172
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
name: L-isoleucine
boundary condition: false
is: CHEBI:17191

http://identifiers.org/biomodels.db/MODEL1310110006#_247b7b22_2bfc_4900_ab71_95d539b3dd67
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: PFKFB1
is encoded by: hsa:5207
is: P16118

metaR 5ADTSTSTERONESte
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110006#
name: sulfonated testosterone transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
is described by: ECO:0000000
type: Reaction
product: MODEL1310110006#
reactant: MODEL1310110006#

metaR r2110
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
fast: false
product: MODEL1310110006#
is: SBO:0000185

metaM hspg l
constant: false
initial concentration: 1.0
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: SBO:0000247
is: HMDB01993
name: heparan sulfate proteoglycan
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:17899
type: Species

metaR DOLASNT Ler
is version of: http://identifiers.org/ec-code/2.4.1.119
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110006#
modifier: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
is: SBO:0000176
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD

metaM etfox m
boundary condition: false
initial concentration: 1.0
is: HMDB00573
name: Electron transfer flavoprotein oxidized
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: R CHARGE: 0
is: CHEBI:30825
type: Species
has only substance units: false

metaM urea e
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: C00086
name: Urea
type: Species
constant: false
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
is: CHEBI:16199
is: HMDB00294
has only substance units: false

metaM thr L e
initial concentration: 1.0
is: HMDB00167
is: SBO:0000247
boundary condition: false
has only substance units: false
name: L-threonine
is: CHEBI:16857
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
constant: false
type: Species
initial amount: NaN

metaM fuc1p L c
initial concentration: 1.0
has only substance units: false
constant: false
name: L-Fucose 1-phosphate
is: CHEBI:28319
is: HMDB01265
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR r0093
kinetic law: MODEL1310110006#
is: SBO:0000176
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45
is version of: http://identifiers.org/ec-code/3.5.1.3
type: Reaction
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:
fast: false
reactant: MODEL1310110006#

metaM thf m
is: CHEBI:57453
constant: false
is: HMDB01846
boundary condition: false
name: 5,6,7,8-Tetrahydrofolate
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: SBO:0000247
initial concentration: 1.0
is: C00101

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM ksii core4 deg1 l
constant: false
is: HMDB00868
name: keratan sulfate II (core 4-linked), degradation product 1
is: SBO:0000247
is: CHEBI:57737
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
type: Species
initial concentration: 1.0

metaR FAOXC164C165m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaR PGISr
name: Prostaglandin I2 synthase
reversible: true
kinetic law: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
reactant: MODEL1310110006#
is described by: ECO:0000134
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.99.4

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

metaM hdcoa c
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: HMDB06532
name: Hexadecenoyl-CoA (n-C16:1CoA)
initial concentration: 1.0

metaR r0627
is: SBO:0000176
fast: false
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
reversible: true
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
reactant: MODEL1310110006#

metaR GALU
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.9
reversible: true
kinetic law: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110006#
reactant: MODEL1310110006#
name: UTP-glucose-1-phosphate uridylyltransferase

metaM acgbgbside hs g
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
name: beta GalNAc globoside
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17411
constant: false
is: HMDB00215
boundary condition: false

metaR FAOXC241C221x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C24:1-->C22:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_61a16eae_062f_4bae_91bb_2c9d1c5af5c6
constant: false
boundary condition: true
is encoded by: hsa:5151
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: PDE8A
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_7bd5de1d_98d0_4d15_bebc_35c1add1834d
is: P50225
is encoded by: hsa:6817
constant: false
boundary condition: true
name: SULT1A1
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaM din c
is: SBO:0000247
type: Species
is: HMDB00071
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: CHEBI:28997
is: C05512
name: Deoxyinosine

http://identifiers.org/biomodels.db/MODEL1310110006#_5cdef70f_8cd4_48a8_b32c_12d595c6ddd7
constant: false
name: ALDOA
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:226

metaM gthrd c
is: CHEBI:57925
initial concentration: 1.0
is: C00051
type: Species
is: SBO:0000247
is: HMDB00125
name: Reduced glutathione
initial amount: NaN
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
boundary condition: false
has only substance units: false
constant: false

metaM k e
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: HMDB00586
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
has only substance units: false
name: potassium
boundary condition: false
is: C00238
is: CHEBI:29103

metaM acgam r
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: SBO:0000247
name: N-acetyl-D-glucosamine
initial concentration: 1.0
is: HMDB00215
is: CHEBI:17411
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_aa3075bd_6032_480b_b924_c9593ec65c3e
constant: false
name: MGAT1
is encoded by: hsa:4245
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P26572

metaM g3m8mpdol L r
type: Species
is: CHEBI:37568
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01342
has only substance units: false
is: C00459

metaM ksi pre36 g
name: keratan sulfate I biosynthesis, precursor 36
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:28067

metaM thr L c
type: Species
constant: false
is: CHEBI:16857
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: L-threonine
is: HMDB00167
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_9e355af2_538c_4b0a_80ed_12c5b75d3c0f
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is: P27707
type: Species
name: DCK
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1633

metaM HC01399 m
has only substance units: false
is: CHEBI:27466
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: (S)-3-Hydroxytetradecanoyl-CoA
boundary condition: false
is: SBO:0000247
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260

metaM HC02217 e
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: prostaglandin-g2
is: CHEBI:27647
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial concentration: 1.0
type: Species
has only substance units: false
constant: false

metaR GGH 6THFe
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (6THF), extracellular
is described by: ECO:0000000
modifier: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9

metaM k c
is: CHEBI:29103
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00586
type: Species
has only substance units: false
constant: false
name: potassium
boundary condition: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: C00238

metaR FACOAL200
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000269
modifier: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#
name: fatty-acid--CoA ligase

http://identifiers.org/biomodels.db/MODEL1310110006#_fb60bbfa_0647_4a2e_9b3a_83ccc5016109
constant: false
initial amount: NaN
boundary condition: true
name: GPI
is encoded by: hsa:2821
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: P06744

http://identifiers.org/biomodels.db/MODEL1310110006#_6355074a_1339_443a_9130_1f8f033d6eca
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:J03866
constant: false
is: SBO:0000252
type: Species
name: _J03866_1_m
boundary condition: true
has only substance units: false

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR EX 3hexdcrn
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_5b8aa304_2932_41b6_b37c_85afda006ac3
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:219
has only substance units: false
name: ALDH1B1
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is: P30837

metaM succoa x
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: HMDB01022
name: Succinyl-CoA
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_2cc17ed8_2574_46a1_a2d8_a874e6c18050
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PDE4C
is: Q7KYS4
has only substance units: false
type: Species
is encoded by: hsa:5143

metaR ADPCOACROT
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

metaR SPODMx
is version of: http://identifiers.org/ec-code/1.15.1.1
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
name: superoxide dismutase, peroxisome
is described by: ECO:0000269
reversible: false
is: SBO:0000176
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
type: Reaction
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_2804f8ce_105d_4835_84bc_b8d296da16e1
boundary condition: true
name: DGKB
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: Q9Y6T7
is encoded by: hsa:1607

metaM din e
is: SBO:0000247
name: Deoxyinosine
type: Species
is: HMDB00071
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28997
boundary condition: false
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: C05512

metaR ADPACTD
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_e8374cb3_246d_48f9_af7e_5a6821811f5f
is: P00374
initial concentration: NaN
is encoded by: hsa:1719
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: DHFR

metaM gthrd e
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00125
initial amount: NaN
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false
boundary condition: false
name: glutathionate(1-)
has only substance units: false
is: CHEBI:57925

metaM adrncoa c
initial concentration: 1.0
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205480
boundary condition: false
initial amount: NaN
has only substance units: false
name: adrenyl coenzyme A
is: C16170
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
type: Species

metaR RTOTAL3FATPc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Rtotal3 by enterocytes
type: Reaction

metaM dcsptn1coa x
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205483
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: C16173
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: HMDB06513
is: SBO:0000247
type: Species
initial amount: NaN

metaR r2118
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110006#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaR RE3272N
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
name: RE3272
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110006#
type: Reaction

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

http://identifiers.org/biomodels.db/MODEL1310110006#_66dd4ee0_2ec9_44f3_bde8_e471fbcadd98
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5152
type: Species
constant: false
boundary condition: true
initial amount: NaN
name: PDE9A
is: SBO:0000252

metaM acgbgbside hs c
type: Species
is: CHEBI:17411
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00215
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
is: SBO:0000247
name: beta GalNAc globoside
constant: false
initial amount: NaN

metaM pnto R e
constant: false
is: CHEBI:7916
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
name: (R)-Pantothenate
is: HMDB00210
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM arachcoa c
boundary condition: false
is: HMDB04258
is: CHEBI:15527
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
name: arachidyl coenzyme A
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: SBO:0000247

metaM nrvnccoa c
is: C16532
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: nervonyl coenzyme A
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
initial concentration: 1.0
constant: false

metaM docohexcoa m
name: 2,4,7,10,13,16-docosahexenoylcoa
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790

metaR C12DCACOT
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

metaR r2119
type: Reaction
modifier: MODEL1310110006#
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110006#
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR G14T13g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
reactant: MODEL1310110006#

metaR UDPGD
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (7358.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES:JLR
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.1.1.22
name: UDPglucose 6-dehydrogenase
reactant: MODEL1310110006#
reversible: false
fast: false

metaM ocdcea r
is: CHEBI:0
boundary condition: false
name: octadecenoate (n-C18:1)
initial concentration: 1.0
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: C00712
is: HMDB00207

http://identifiers.org/biomodels.db/MODEL1310110006#_c7181b2b_65e6_4b03_948c_119469d00297
is encoded by: hsa:130
type: Species
constant: false
initial amount: NaN
boundary condition: true
name: ADH6
initial concentration: NaN
is: SBO:0000252
is: P28332
has only substance units: false

metaR r1695
reversible: false
modifier: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110006#

metaM HC02203 c
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: CHEBI:27820
name: prostaglandin-a2
initial amount: NaN
has only substance units: false

metaR LDH L
is version of: http://identifiers.org/ec-code/1.1.1.27
name: L-lactate dehydrogenase
reversible: true
reactant: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
is described by: ECO:0000000

metaM CE0693 m
type: Species
is: HMDB11123
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
has only substance units: false
is: CHEBI:28387
name: 3-oxolaur-6-cis-enoyl-CoA

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

metaM dolp L r
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57683
boundary condition: false
has only substance units: false
type: Species
name: dolichyl phosphate(2-)

metaM L2aadp6sa c
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: SBO:0000247
initial amount: NaN
is: CHEBI:17917
boundary condition: false
is: HMDB01263
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
name: L-allysine

metaR r2116
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
modifier: MODEL1310110006#

metaR EX 3thexddcoacrn
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans7,10-hexadecadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_c946348c_f6bc_4c46_83b8_53d01dd38415
name: PDE7A
is encoded by: hsa:5150
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: Q13946
boundary condition: true

metaM 3mob m
is: SBO:0000247
name: 3-methyl-2-oxobutanoate
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: CHEBI:11851
boundary condition: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
is: HMDB00019

metaR B3GALT3g
reversible: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.79
kinetic law: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
name: Beta-1,3-galactosyltransferase 3
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_5d08a229_925c_4af8_ba97_6ce07074f02d
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
name: SLC22A5
is: O76082
boundary condition: true
is encoded by: hsa:6584
is: SBO:0000252
has only substance units: false

metaM nadh r
initial concentration: 1.0
type: Species
name: NADH(2-)
has only substance units: false
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57945
initial amount: NaN
is: HMDB01487

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaM xoldiolone c
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB02197
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:28477
type: Species
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one

metaR SUCD1m
reactant: MODEL1310110006#
reversible: true
name: succinate dehydrogenase
kinetic law: MODEL1310110006#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.5.1
modifier: MODEL1310110006#
product: MODEL1310110006#

metaR r2117
type: Reaction
fast: false
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110006#

metaM nadp x
is: HMDB00217
is: CHEBI:58349
is: C00006
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
name: Nicotinamide adenine dinucleotide phosphate
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR r1459
name: Transport reaction
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110006#_623b6222_9886_44b4_939e_68022d246136
name: SLC35D1
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23169
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: Q9NTN3

metaM pnto R c
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:7916
boundary condition: false
name: (R)-Pantothenate
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
constant: false
is: HMDB00210
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_c9bf0ccc_f52d_435f_91f8_ac874f36c93e
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:8608
name: RDH16
initial concentration: NaN
has only substance units: false
is: O75452

orgname: University of Iceland

metaR RDH3a
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.300
modifier: MODEL1310110006#
is: SBO:0000176
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.105
is described by: ECO:0000269
name: retinol dehydrogenase (11-cis,NADPH)
type: Reaction
product: MODEL1310110006#

metaR FAOXC5C5OHm
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C5OH)m
type: Reaction

metaR RE2541E
type: Reaction
name: RE2541
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
reversible: true
kinetic law: MODEL1310110006#
fast: false
product: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110006#

metaR FAOXC102m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

metaR FAOXC163C142x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_7fc8a339_3398_4607_aa46_e170680f8278
constant: false
initial amount: NaN
is: Q8TF71
is: SBO:0000252
has only substance units: false
name: SLC16A10
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:117247

metaR VALtec
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
fast: false
product: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
name: L-valine transport via diffusion (extracellular to cytosol)

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaM thf e
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
is: CHEBI:57453
boundary condition: false
is: HMDB01846
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
has only substance units: false

metaR B3GNT311g
reversible: false
is described by: ECO:0000254
fast: false
is: SBO:0000176
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
modifier: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110006#_9609c672_fe4d_49ed_ac97_e47511351f8e
is encoded by: hsa:56301
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: Q9NS82
name: SLC7A10
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_ab640291_0eb2_43e4_a65e_d99f86c17ce1
is: SBO:0000252
type: Species
name: COX7B2
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:170712
is: Q8TF08
constant: false

metaM 10fthf5glu e
is: SBO:0000247
constant: false
is: CHEBI:57454
is: HMDB00972
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C40H45N11O19 CHARGE: -6
boundary condition: false
type: Species
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](5)

W3 CDTF: Fri Aug 31 06:03:21 BST 2012

metaR FAOXC81C61m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaM prostgi2 r
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB01335
is: CHEBI:57403
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
name: prostaglandin I2(1-)
type: Species
boundary condition: false
constant: false

metaR r1587
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110006#
product: MODEL1310110006#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110006#

metaR r0732
fast: false
kinetic law: MODEL1310110006#
type: Reaction
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
reactant: MODEL1310110006#
reversible: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is: SBO:0000176

metaM cs e deg5 l
initial concentration: 1.0
is: CHEBI:57737
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 5
notes: FORMULA: C31H47NO35S3 CHARGE: -4
is: HMDB00868
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_9472beb0_d0ba_4b9d_80cc_3f36e67ade12
initial concentration: NaN
name: GUCY2D
boundary condition: true
is encoded by: hsa:3000
is: SBO:0000252
is: Q02846
type: Species
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_c4d46f32_1813_4653_905e_c149e9d59062
name: TPH2
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is: Q8IWU9
boundary condition: true
constant: false
is encoded by: hsa:121278

metaM ksi deg41 l
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:12936
type: Species
notes: FORMULA: C34H58N2O26 CHARGE: 0
is: HMDB00143
name: keratan sulfate I, degradation product 41
initial concentration: 1.0

metaM xol7ah2al c
initial concentration: 1.0
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: false
is: HMDB06894
is: CHEBI:27428
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_954c874d_dc34_489c_a70d_3d4ce6f2cc91
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:7108
is: O76062
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: TM7SF2

metaM sbt D e
name: D-glucitol
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00247
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110006#_044c04f0_d9bd_47bc_ba1f_476059416ed1
boundary condition: true
is encoded by: hsa:30
is: SBO:0000252
name: ACAA1
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: Q96CA6
initial concentration: NaN

metaR M13N2Tg
kinetic law: MODEL1310110006#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.101
is described by: ECO:0000000
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
modifier: MODEL1310110006#
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
reactant: MODEL1310110006#
is: SBO:0000176
type: Reaction

metaM 3mob c
is: HMDB00019
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:11851
constant: false
name: 3-methyl-2-oxobutanoate
is: SBO:0000247
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
type: Species

metaR NDPK6m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
reactant: MODEL1310110006#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
is described by: ECO:0000254
type: Reaction

W3 CDTF: Fri Aug 31 06:03:21 BST 2012

metaR CRNrtx
reactant: MODEL1310110006#
name: reversible transport of L-Carnitine in peroxisome
is: SBO:0000185
product: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
type: Reaction
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110006#

metaR GDPtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reversible: true
fast: false
name: GDP intracellular transport
is: SBO:0000185
reactant: MODEL1310110006#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_3d73a46d_0f79_4ca6_88bd_365fa8f77857
is encoded by: hsa:1120
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: A0PJM6
is: SBO:0000252
name: CHKB

http://identifiers.org/biomodels.db/MODEL1310110006#_801e5475_b546_4b31_9363_fd20c0f93269
name: _R14373_1_x
constant: false
is encoded by: hsa:R14373
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM dlnlcg c
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
initial concentration: 1.0
constant: false
is: CHEBI:53486
type: Species
is: SBO:0000247
name: dihomo-gamma-linolenic acid (n-6)
initial amount: NaN
is: HMDB02925
has only substance units: false
boundary condition: false

metaR ORPT
product: MODEL1310110006#
modifier: MODEL1310110006#
name: orotate phosphoribosyltransferase
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
reactant: MODEL1310110006#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.10
kinetic law: MODEL1310110006#
reversible: true
is: SBO:0000176
fast: false

metaR r1586
reactant: MODEL1310110006#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110006#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110006#

metaR r0733
product: MODEL1310110006#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
fast: false
modifier: MODEL1310110006#
is: SBO:0000176

metaM Rtotal2 c
initial amount: NaN
name: R total 2 position
is: SBO:0000247
is: CHEBI:60377
is: C00055
initial concentration: 1.0
has only substance units: false
is: HMDB00095
boundary condition: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_1e112bfa_1e20_4816_ac1a_c0491645339c
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: AGXT2
is: SBO:0000252
is: Q9BYV1
is encoded by: hsa:64902
constant: false

metaR SPODMn
is: SBO:0000176
type: Reaction
reactant: MODEL1310110006#
name: superoxide dismutase, nuclear
fast: false
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
product: MODEL1310110006#
is described by: ECO:0000269
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.15.1.1
reversible: false

W3 CDTF: Fri Aug 31 06:03:21 BST 2012

metaM dttp m
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
name: dTTP
is: HMDB01342
is: C00459
boundary condition: false

metaM arachcoa m
has only substance units: false
name: arachidyl coenzyme A
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:15527
is: SBO:0000247
constant: false
is: HMDB04258
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_8c5886fa_d03a_416b_90d7_c55287f3f4da
is: O14556
constant: false
boundary condition: true
initial amount: NaN
name: GAPDHS
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:26330
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_3a65cc78_a1b4_407d_b3cf_807c301d0013
initial concentration: NaN
constant: false
is: P05062
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:229
has only substance units: false
name: ALDOB

metaR HIVCRNe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

metaR GALK
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.6
name: galactokinase
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.157
type: Reaction
reactant: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
product: MODEL1310110006#

metaR r1585
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110006#_c5fd1d1a_e255_4977_838d_2b597107cd0e
has only substance units: false
is encoded by: hsa:U37519
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: _U37519_1_c
boundary condition: true
constant: false

metaR r1456
name: Transport reaction
product: MODEL1310110006#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#

metaR PYDAMK
fast: false
type: Reaction
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.35
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110006#
modifier: MODEL1310110006#
name: pyridoxamine kinase
reversible: false
product: MODEL1310110006#

metaM sbt D c
name: D-glucitol
boundary condition: false
is: HMDB00247
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
constant: false
initial concentration: 1.0
is: CHEBI:17924

metaR r0730
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
reactant: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
fast: false
product: MODEL1310110006#
modifier: MODEL1310110006#
reversible: false

metaR C16OHc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecanoylcarnitinec
type: Reaction

metaM dag hs c
initial amount: NaN
has only substance units: false
is: CHEBI:18035
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
name: diglyceride

metaR FAOXC123m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

metaM dttp n
has only substance units: false
is: C00459
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:37568
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
name: dTTP
is: HMDB01342
type: Species

W3 CDTF: Fri Aug 31 06:03:21 BST 2012

metaM CE2431 m
initial concentration: 1.0
is: CHEBI:57795
constant: false
boundary condition: false
name: cis-deca-4-enoyl-CoA
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
is: SBO:0000247

metaM gthrd m
initial amount: NaN
name: glutathionate(1-)
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00125
is: CHEBI:57925
type: Species
initial concentration: 1.0
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051

metaM HC02203 e
name: prostaglandin-a2
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:27820
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial amount: NaN
has only substance units: false
boundary condition: false

metaR EX ddece1crn
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecenoyl carnitine
type: Reaction

metaM 4hoxpacd c
initial concentration: 1.0
constant: false
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
is: HMDB03767
is: SBO:0000247
initial amount: NaN
name: (4-hydroxyphenyl)acetaldehyde
boundary condition: false
is: CHEBI:15621
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_e365543f_1653_4ecf_a749_29e41774ccae
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: HMGCS2
type: Species
is encoded by: hsa:3158
initial amount: NaN
is: P54868

metaM L2aadp6sa m
boundary condition: false
is: CHEBI:17917
has only substance units: false
name: L-allysine
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB01263
is: SBO:0000247
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076

metaM gthox c
is: SBO:0000247
initial concentration: 1.0
is: HMDB03337
is: CHEBI:58297
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
name: Oxidized glutathione
is: C00127
type: Species

metaM HC02216 e
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
is: CHEBI:28922
boundary condition: false
has only substance units: false
constant: false
name: prostaglandin-f2beta

metaR r1455
reactant: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110006#
is described by: ECO:0000000
name: Transport reaction
type: Reaction

metaR r1584
kinetic law: MODEL1310110006#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR S2L2N2M2MASNtly
product: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110006#
name: s2l2n2m2masn transport, extracellular to lysosome
fast: false
type: Reaction
is described by: ECO:0000000

metaR r0731
product: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reversible: false
kinetic law: MODEL1310110006#
type: Reaction
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is described by: ECO:0000000
fast: false
reactant: MODEL1310110006#

metaR IPDPtx
name: Isopentenyl diphosphate transport (peroxisome)
fast: false
type: Reaction
product: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
is described by: ECO:0000134
is: SBO:0000185
reversible: true
reactant: MODEL1310110006#

metaM nadh x
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
is: SBO:0000247
is: CHEBI:57945
has only substance units: false
type: Species
is: C00004
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01487
name: Nicotinamide adenine dinucleotide - reduced

http://identifiers.org/biomodels.db/MODEL1310110006#_af7a2f99_b8ad_4496_9ecd_a14e1200b3d0
name: GSTZ1
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: A6NED0
initial amount: NaN
is encoded by: hsa:2954
boundary condition: true

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaR MI14Ptn
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110006#

metaM tststerone r
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00234
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
type: Species
is: CHEBI:17347
constant: false
has only substance units: false
name: testosterone

metaR r1454
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110006#
is: SBO:0000185
fast: false

metaR RE3524R
kinetic law: MODEL1310110006#
reversible: true
product: MODEL1310110006#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
reactant: MODEL1310110006#
is described by: ECO:0000000
fast: false
name: RE3524

metaM HC02216 c
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial amount: NaN
is: CHEBI:28922
name: prostaglandin-f2beta
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM succoa m
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
has only substance units: false
is: CHEBI:57292
is: SBO:0000247
type: Species
is: HMDB01022
initial amount: NaN
constant: false
boundary condition: false
name: Succinyl-CoA

metaM dag hs e
type: Species
name: diglyceride
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
boundary condition: false
is: CHEBI:18035
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN

metaM pail3p hs c
is: CHEBI:58088
constant: false
boundary condition: false
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR ETFQO
reactant: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
product: MODEL1310110006#
type: Reaction
fast: false
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.5.5.1
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_26e6388a_4056_4e3b_afeb_b3610f380e9a
is: Q9BV79
type: Species
is encoded by: hsa:51102
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
name: MECR

metaM dcsptn1coa m
constant: false
is: C16173
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205483
type: Species
has only substance units: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: HMDB06513
boundary condition: false

metaR r1453
reactant: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
product: MODEL1310110006#
fast: false
is described by: ECO:0000000
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
is: SBO:0000176
type: Reaction

metaR FACOAL203
modifier: MODEL1310110006#
product: MODEL1310110006#
name: fatty-acid--CoA ligase
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110006#
type: Reaction

metaM ksii core2 deg3 l
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
is: SBO:0000247
is: HMDB00143
is: CHEBI:12936
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 3
constant: false
type: Species

metaM dcacoa x
is: CHEBI:61430
has only substance units: false
constant: false
boundary condition: false
type: Species
is: HMDB06404
initial amount: NaN
is: C05274
initial concentration: 1.0
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: SBO:0000247
name: Decanoyl-CoA (n-C10:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110006#_2667b32c_1c14_49ec_aa80_f537eca054d8
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: B3GNT7
is: Q8NFL0
is encoded by: hsa:93010
is: SBO:0000252
initial amount: NaN

metaM 3hexdtricoa x
initial concentration: 1.0
name: 3,7,10-hexadecatrienoylcoa
has only substance units: false
is: HMDB02288
is: SBO:0000247
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
constant: false
boundary condition: false

metaM ade e
type: Species
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: CHEBI:16708
has only substance units: false
name: adenine
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00034

metaR ARACHCRNt
reactant: MODEL1310110006#
reversible: false
product: MODEL1310110006#
is described by: ECO:0000000
modifier: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
is: SBO:0000185
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction

metaR r0629
is version of: http://identifiers.org/ec-code/3.6.1.22
is: SBO:0000176
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.1
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
reversible: true
modifier: MODEL1310110006#

metaM hdcoa m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
is: SBO:0000247
name: Hexadecenoyl-CoA (n-C16:1CoA)
type: Species
is: HMDB06532
constant: false
boundary condition: false
has only substance units: false

metaM HC00591 c
type: Species
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
has only substance units: false
boundary condition: false
is: CHEBI:16769
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
name: 2-oxoglutaramate

metaR VLCSp
is version of: http://identifiers.org/ec-code/6.2.1.3
name: Very-long-chain-fatty-acid-CoA ligase
is: SBO:0000176
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
fast: false
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ

metaR RE1525M
name: RE1525
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110006#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR r0734
fast: false
product: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110006#
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_024b21a2_777e_4018_92dd_e86a0e600df8
is: P50053
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:3795
type: Species
boundary condition: true
initial amount: NaN
name: KHK

metaM urea c
boundary condition: false
constant: false
type: Species
has only substance units: false
is: CHEBI:16199
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
name: Urea
is: HMDB00294
initial concentration: 1.0
initial amount: NaN
is: C00086
is: SBO:0000247

metaM HC01403 m
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
is: CHEBI:28325
boundary condition: false
name: (S)-Hydroxydecanoyl-CoA

metaM 3mob e
boundary condition: false
is: CHEBI:11851
name: 3-methyl-2-oxobutanoate
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1

metaR r1589
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110006#
reversible: true
fast: false
reactant: MODEL1310110006#

metaR FACOAL204
fast: false
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
name: fatty-acid--CoA ligase
modifier: MODEL1310110006#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
reversible: true

metaM ksii core2 pre10 g
boundary condition: false
constant: false
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
is: CHEBI:28067
type: Species
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 10
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR NACHEX14ly
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110006#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_38345633_a122_4984_91ee_c7e928b9fd43
name: CHST4
is: Q8NCG5
is encoded by: hsa:10164
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_47bda4ec_5536_4c44_9827_de3fe3372bac
has only substance units: false
is encoded by: hsa:2348
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: FOLR1

metaR DOLP Lter
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
name: dolichol phosphate flippase (liver)
is: SBO:0000176
product: MODEL1310110006#

metaR r0735
is: SBO:0000176
reactant: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
fast: false
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

metaM CE2434 m
constant: false
is: SBO:0000247
type: Species
is: CHEBI:57795
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
has only substance units: false
initial concentration: 1.0
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
initial amount: NaN
boundary condition: false

metaR RE0452M
kinetic law: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
fast: false
is: SBO:0000176
name: RE0452
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
is described by: ECO:0000000

metaR FAOXC163C164x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaR IDOURtly
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
type: Reaction
name: iduronate transport into lysososme
modifier: MODEL1310110006#
is: SBO:0000185
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
product: MODEL1310110006#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110006#_395b5406_c625_4b91_8279_7297de0a233e
is encoded by: hsa:50814
name: NSDHL
type: Species
initial amount: NaN
constant: false
is: Q15738
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_2ffcd523_1c03_4cd3_af57_168e44f1b0b2
constant: false
name: SLC10A2
is: Q12908
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:6555
boundary condition: true

metaR KYNAKGAT
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
reactant: MODEL1310110006#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.7
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: false
name: L-Kynurenine:2-oxoglutarate aminotransferase
kinetic law: MODEL1310110006#
fast: false
type: Reaction
product: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176

metaR r1588
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is described by: ECO:0000000

metaR FAOXC164C165x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_2785fbfd_4e68_4ebc_9fdc_9158627e1eb3
initial amount: NaN
boundary condition: true
is: P34059
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2588
type: Species
name: GALNS

http://identifiers.org/biomodels.db/MODEL1310110006#_3db2ae7e_c0fa_42ea_bee2_f6f9bd529241
boundary condition: true
name: SLC26A6
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:65010
is: Q548A7
has only substance units: false
initial amount: NaN

metaR FACOAL205
kinetic law: MODEL1310110006#
product: MODEL1310110006#
name: fatty-acid--CoA ligase
modifier: MODEL1310110006#
reactant: MODEL1310110006#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_e1f821de_78df_478e_bbfb_014c0cfe2e13
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is: Q9NY65
is encoded by: hsa:1962
initial concentration: NaN
name: EHHADH
constant: false
initial amount: NaN

metaM chlstol r
is: HMDB06842
is: SBO:0000247
name: 5alpha-cholesta-7,24-dien-3beta-ol
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
is: CHEBI:16290

metaR UDPGP
notes: GENE_ASSOCIATION: (5167.1) or (5169.1) or (5168.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.1
product: MODEL1310110006#
modifier: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
name: UDPglucose pyrophosphohydrolase
is version of: http://identifiers.org/ec-code/3.1.4.39

metaR NRPPHRt4 2 r
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110006#
type: Reaction
fast: false
name: Norepinephrine reversible transport in via sodium symport (1:2)
reactant: MODEL1310110006#
is: SBO:0000185
product: MODEL1310110006#
kinetic law: MODEL1310110006#

metaR r1590
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
product: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaM nadh c
is: SBO:0000247
name: Nicotinamide adenine dinucleotide - reduced
type: Species
is: HMDB01487
boundary condition: false
is: C00004
constant: false
has only substance units: false
is: CHEBI:57945
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0

metaM nadp m
is: C00006
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
boundary condition: false
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate
constant: false
type: Species
is: CHEBI:58349
is: HMDB00217

metaM lys L m
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00182
is: CHEBI:32551
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial amount: NaN
boundary condition: false
constant: false

metaM fol c
boundary condition: false
name: Folate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: SBO:0000247
has only substance units: false
is: HMDB00121
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_392c80ae_9875_4a59_8eee_06439f6af52d
initial amount: NaN
initial concentration: NaN
is: P16930
name: FAH
constant: false
is encoded by: hsa:2184
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

metaR TDCRNe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

metaR HEDCECRNe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecenoyl carnitine into extra cellular space
type: Reaction

metaR r1591
product: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is: SBO:0000185
reversible: true

metaR DESAT24 1
type: Reaction
fast: false
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
modifier: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110006#
name: fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)

metaM na1 r
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: HMDB00588
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
name: sodium(1+)
initial concentration: 1.0
constant: false
is: CHEBI:29101
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_397baf90_a5ae_4703_b4fe_243876e6aa3b
initial concentration: NaN
is: O95139
name: NDUFB6
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:4712
boundary condition: true
type: Species

metaM leugly e
type: Species
notes: FORMULA: C8H16N2O3 CHARGE: 0
name: Leucylglycine
has only substance units: false
is: http://identifiers.org/pubchem.compound/97364
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR ACOAO7p
product: MODEL1310110006#
reversible: false
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000269
modifier: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
is: SBO:0000176

metaM 3hexdtetcoa m
type: Species
is: HMDB02288
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
name: 3,7,10,13-hexadecatetraenoylcoa
is: SBO:0000247

metaM gua e
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: HMDB00132
name: guanine
is: CHEBI:16235
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_c2e527e6_3248_4744_b695_fd52c738309d
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: Q96M32
is encoded by: hsa:122481
name: AK7

metaM ocdcea e
initial concentration: 1.0
name: octadecenoate (n-C18:1)
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:0
is: C00712
initial amount: NaN
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1
is: HMDB00207
type: Species

metaR S6TASE17ly
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110006#
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
product: MODEL1310110006#
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
reactant: MODEL1310110006#

metaM ade c
is: CHEBI:16708
boundary condition: false
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
initial amount: NaN
is: C00147
is: HMDB00034
initial concentration: 1.0
type: Species
name: Adenine
is: SBO:0000247
constant: false
has only substance units: false

metaM hdd2coa x
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: HMDB03945
name: (E)-hexadec-2-enoyl-CoA(4-)
has only substance units: false
type: Species
is: CHEBI:61526
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_c538fa8d_3071_4cda_a08b_153139235e3d
has part: Q8TEQ8
has only substance units: false
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:84720
name: PIGF:PIGO
boundary condition: true
constant: false
type: Species
is encoded by: hsa:5281
has part: Q07326

http://identifiers.org/biomodels.db/MODEL1310110006#_e4c63203_f19d_432f_8681_48f4c0f42686
initial amount: NaN
is encoded by: hsa:8790
is: SBO:0000252
is: O14772
name: FPGT
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false

metaR LEUKTRB4t
fast: false
is described by: ECO:0000000
name: leukotriene B4 transport
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110006#
type: Reaction
reversible: true

metaM cys L e
is: HMDB00574
has only substance units: false
initial amount: NaN
name: L-cysteine
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
type: Species
is: CHEBI:17561
boundary condition: false

metaR NAGA2ly
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.49
is described by: ECO:0000000
modifier: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
fast: false
type: Reaction
name: N-acetylgalactosaminidase, alpha-
is: SBO:0000176
reactant: MODEL1310110006#
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_24c56fae_d053_4ccd_a3c8_712117a046e9
initial concentration: NaN
name: GALNTL2
is encoded by: hsa:117248
initial amount: NaN
type: Species
has only substance units: false
is: Q8N3T1
boundary condition: true
constant: false
is: SBO:0000252

metaM lnlncg e
has only substance units: false
is: HMDB03073
is: CHEBI:32391
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: gamma-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
type: Species
constant: false

metaM ksii core4 pre3 g
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:58053
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C55H89N5O38X CHARGE: -1
is: HMDB00175
is: C00130
name: keratan sulfate II biosynthesis, precursor 3

metaM fol e
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
name: Folate
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1
boundary condition: false
is: SBO:0000247

metaM glyc m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00116
type: Species
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: HMDB00131
initial amount: NaN
has only substance units: false
name: Glycerol

metaM acgam c
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:17411
name: N-acetyl-D-glucosamine
is: HMDB00215
type: Species
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
boundary condition: false
is: SBO:0000247

metaR FAOXC226
is described by: ECO:0000000
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110006#
fast: false
product: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR S6T18g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.17
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.8.2.21
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
product: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#

metaR B3GNT12g
reversible: false
fast: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (10678.1) or (10678.2) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
reactant: MODEL1310110006#
is described by: ECO:0000269
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110006#

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

metaR FAOXC163C143m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:3)m
type: Reaction

metaR GALASE7ly
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
fast: false
name: beta-galactosidase, lysosomal
is: SBO:0000176
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false

metaM leugly c
notes: FORMULA: C8H16N2O3 CHARGE: 0
boundary condition: false
name: Leucylglycine
constant: false
is: http://identifiers.org/pubchem.compound/97364
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM ocdcea c
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:0
notes: FORMULA: C18H33O2 CHARGE: -1
is: C00712
initial amount: NaN
constant: false
type: Species
is: HMDB00207
initial concentration: 1.0
name: octadecenoate (n-C18:1)

metaR FTCD
modifier: MODEL1310110006#
product: MODEL1310110006#
name: formimidoyltransferase cyclodeaminase
fast: false
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
is described by: ECO:0000134
reversible: false
is: SBO:0000176
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.1.2.5
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_241d4d2d_d945_49cc_a34e_dfee9e155a24
is: Q8WYR1
constant: false
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:23533
name: PIK3R5
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_d563897f_1c4e_43ab_8bbe_e76c1fb0546e
is: P43353
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
name: ALDH3B1
is: SBO:0000252
is encoded by: hsa:221

metaM gua c
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
constant: false
is: CHEBI:16235
has only substance units: false
boundary condition: false
is: C00242
is: HMDB00132
name: Guanine
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR r1594
is: SBO:0000185
reactant: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110006#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_3ec342d1_8a16_4e0c_97c4_8e69f33634fd
is encoded by: hsa:T83654
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: _T83654_1_c
type: Species
is: SBO:0000252

metaM lnlncg c
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial concentration: 1.0
is: CHEBI:32391
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: HMDB03073
is: SBO:0000247
name: gamma-linolenate

http://identifiers.org/biomodels.db/MODEL1310110006#_5a08dfca_5b01_4c2b_bf71_4c7404829c14
has only substance units: false
name: SLC22A2
initial concentration: NaN
constant: false
is encoded by: hsa:6582
boundary condition: true
initial amount: NaN
is: O15244
is: SBO:0000252
type: Species

metaM c8crn c
constant: false
notes: FORMULA: C15H29NO4 CHARGE: 0
name: octanoyl carnitine
is: C02838
type: Species
boundary condition: false
is: HMDB00791
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM cit m
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0
name: Citrate
boundary condition: false
is: HMDB00094
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:16947
initial amount: NaN
is: C00158
constant: false

metaM ocdececrn c
notes: FORMULA: C25H47NO4 CHARGE: 0
is: HMDB06351
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
name: 11-octadecenoyl carnitine
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_094ba6b4_e3a9_4b32_bce5_cefe7dd2e8e0
initial amount: NaN
constant: false
name: ACSL6
boundary condition: true
type: Species
is: B2RB13
is encoded by: hsa:23305
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR S3TASE1ly
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
name: N-acetylglucosamine-3-sulfatase, lysosomal
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_b7b54123_b1e1_4fbe_ba01_e7d30e79fd19
type: Species
is encoded by: hsa:5214
is: Q5VSR7
is: SBO:0000252
has only substance units: false
name: PFKP
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_ff1dc5cb_9cd8_46df_be70_60628bc10f07
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7360
name: UGP2
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
constant: false

metaM cys L c
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: L-cysteine
is: CHEBI:17561
is: HMDB00574
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
constant: false
has only substance units: false

metaR FAOXC123C102m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaR r1595
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110006#
reversible: true
type: Reaction
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_58cec740_f9c8_4dbb_a1a7_7b61cb505a79
constant: false
is encoded by: hsa:9152
type: Species
initial concentration: NaN
boundary condition: true
is: Q9Y345
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SLC6A5

metaR FAOXC16C16OHm
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C16OH)m
type: Reaction

metaR GLNS
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: false
type: Reaction
name: glutamine synthetase
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000254
fast: false
reactant: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.1.1.15

metaM mlthf m
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial amount: NaN
name: 5,10-Methylenetetrahydrofolate
constant: false
is: CHEBI:15636
is: HMDB01533
is: C00143
is: SBO:0000247
boundary condition: false
type: Species

metaR CTPtn
is described by: ECO:0000000
name: CTP diffusion in nucleus
is: SBO:0000185
reversible: true
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
fast: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#

metaR RE2799C
reversible: true
is described by: ECO:0000000
product: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
name: RE2799
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
is: SBO:0000176

metaR NDPK5n
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110006#
is: SBO:0000176
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
type: Reaction
product: MODEL1310110006#
is described by: ECO:0000304

metaR TETPENT3t
product: MODEL1310110006#
is: SBO:0000185
fast: false
name: fatty acid transport via diffusion
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110006#
is described by: ECO:0000000
reversible: true

metaR RE2988X
kinetic law: MODEL1310110006#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
modifier: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
reversible: true
fast: false
name: RE2988
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_1f235880_ca8f_45f8_bfc0_252fcb29f7e3
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:8818
has only substance units: false
is: SBO:0000252
name: DPM2

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_0abc89ba_0eb0_45e7_878b_1c914b91a499
initial amount: NaN
is: P16278
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2720
initial concentration: NaN
constant: false
has only substance units: false
name: GLB1
type: Species

metaR r1592
is: SBO:0000185
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110006#
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110006#

metaM Rtotal2 e
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:3554
is: HMDB00244
name: R total 2 position
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: C00255
notes: FORMULA: CO2FULLR2 CHARGE: -1

metaM succoa c
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: HMDB01022
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
name: Succinyl-CoA
has only substance units: false
is: SBO:0000247
constant: false

metaM dlnlcg e
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
initial concentration: 1.0
is: HMDB02925
type: Species
constant: false
is: CHEBI:53486
boundary condition: false
name: dihomo-gamma-linolenic acid (n-6)
is: SBO:0000247

metaM pydxn c
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
is: CHEBI:16709
name: Pyridoxine
is: C00314
is: SBO:0000247
initial amount: NaN
is: HMDB00239
boundary condition: false
has only substance units: false
type: Species
constant: false
initial concentration: 1.0

metaM hs deg2 l
name: heparan sulfate, degradation product 2
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
initial concentration: 1.0
is: HMDB01352
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:17180
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_0ce8bdfa_d988_484d_b73e_fbf23cf0c6ba
has only substance units: false
name: H6PD
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: O95479
boundary condition: true
is encoded by: hsa:9563

http://identifiers.org/biomodels.db/MODEL1310110006#_435f2929_ca6a_4ae8_b90f_31984d5f2ccf
has only substance units: false
initial concentration: NaN
is: O75521
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10455
type: Species
name: ECI2
constant: false

metaR G16MT L
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
type: Reaction
product: MODEL1310110006#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_2892e413_a333_47b4_93d1_8b213f903785
type: Species
initial concentration: NaN
boundary condition: true
name: _AI926493_1_c
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI926493

metaR r1593
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110006#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
fast: false

metaM hs deg12 l
initial amount: NaN
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
constant: false
is: HMDB01352
type: Species
is: CHEBI:17180
name: heparan sulfate, degradation product 12
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_d00c7a17_2a8a_40c6_bdd6_5fb96598d114
boundary condition: true
is: SBO:0000252
constant: false
is: P49247
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:22934
initial concentration: NaN
name: RPIA

metaM dolp L c
constant: false
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247
is: CHEBI:57683
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
name: dolichyl phosphate(2-)

metaM c8crn e
has only substance units: false
notes: FORMULA: C15H29NO4 CHARGE: 0
is: HMDB00791
type: Species
initial concentration: 1.0
name: octanoyl carnitine
is: SBO:0000247
is: C02838
constant: false
initial amount: NaN
boundary condition: false

metaM g3p c
name: Glyceraldehyde 3-phosphate
is: C00661
is: SBO:0000247
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: CHEBI:58027
initial amount: NaN
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3930
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB01112

metaM m2gacpail hs r
is: SBO:0000247
initial concentration: 1.0
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16038

metaR FAOXC160
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_659d4407_c0b9_40df_99e9_7669bfd7ddec
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is: Q9Y3Y1
initial amount: NaN
name: SLC26A6
initial concentration: NaN
is encoded by: hsa:65010

metaR NACHEX25ly
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
modifier: MODEL1310110006#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52

http://identifiers.org/biomodels.db/MODEL1310110006#_486ccb20_eed9_43a0_a41c_5b602ff8f7ed
is: Q9Y6M9
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: NDUFB9
is encoded by: hsa:4715
is: SBO:0000252
type: Species

metaM hexc e
constant: false
is: CHEBI:31013
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: cerotate
is: HMDB02356
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
type: Species
initial concentration: 1.0

metaR r2127
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
type: Species
boundary condition: false
is: CHEBI:61648
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
constant: false
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
initial amount: NaN

metaM eipencoa x
initial concentration: 1.0
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
name: 2,5,8,11,14-eicosapentaenoylcoa
constant: false

metaM lys L e
is: HMDB00182
is: CHEBI:32551
name: L-lysinium(1+)
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
boundary condition: false
initial amount: NaN

metaM msa m
initial concentration: 1.0
type: Species
is: CHEBI:33190
is: HMDB11111
boundary condition: false
is: SBO:0000247
name: 3-oxopropanoate
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
constant: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_558e78f0_2c04_409c_8edb_f43556b0e67e
has only substance units: false
is encoded by: hsa:79143
type: Species
constant: false
name: MBOAT7
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q96N66

metaM c12dccoa c
name: dodecanedioylcoa
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: HMDB00623
notes: FORMULA: C33H51N7O19P3S CHARGE: -5

metaR OCDCEAtr
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: fatty acid transport via diffusion
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reactant: MODEL1310110006#
product: MODEL1310110006#
reversible: true

metaR FADDPle
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
modifier: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
reversible: false
name: FAD diphosphatase
is: SBO:0000176
product: MODEL1310110006#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.1.4.1
reactant: MODEL1310110006#

metaM hdd2coa m
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: CHEBI:61526
boundary condition: false
is: C05272
initial amount: NaN
type: Species
name: trans-Hexadec-2-enoyl-CoA
is: HMDB03945
has only substance units: false
constant: false
initial concentration: 1.0

metaM tststerone e
initial amount: NaN
is: SBO:0000247
is: HMDB00234
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: CHEBI:17347
has only substance units: false
name: testosterone

metaM HC00591 m
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
type: Species
constant: false
name: 2-oxoglutaramate
has only substance units: false
is: CHEBI:16769

http://identifiers.org/biomodels.db/MODEL1310110006#_ee3f509d_3ed5_4651_868a_8323ab04fe3c
is: SBO:0000252
is: O75489
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:4722
initial amount: NaN
type: Species
name: NDUFS3

metaM fol m
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1 INCHI: InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00396 EHMN_ABBREVIATION: C00504
is: SBO:0000247
is: CHEBI:27470
boundary condition: false
name: Folate
initial concentration: 1.0

metaR CITt4 4
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
product: MODEL1310110006#
name: citrate transport via sodium symport
kinetic law: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
is: SBO:0000185
reactant: MODEL1310110006#
reversible: true
is described by: ECO:0000006
fast: false

metaR r2126
product: MODEL1310110006#
modifier: MODEL1310110006#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
reactant: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185

metaR FAOXC102x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_d616d964_1b9e_4dda_afde_9b3375380617
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is: P00390
is encoded by: hsa:2936
boundary condition: true
initial amount: NaN
constant: false
name: GSR

metaR MM8Cg
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
fast: false
modifier: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is described by: ECO:0000000
reversible: false
is: SBO:0000176
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.113

metaR XOLTRIOLtm
name: lipid, flip-flop intracellular transport
product: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
fast: false

metaM nadh m
constant: false
is: SBO:0000247
is: C00004
is: HMDB01487
boundary condition: false
has only substance units: false
name: Nicotinamide adenine dinucleotide - reduced
initial amount: NaN
is: CHEBI:57945
is: http://identifiers.org/pubchem.compound/3306
initial concentration: 1.0
type: Species

metaM glyc e
is: SBO:0000247
initial amount: NaN
is: C00116
has only substance units: false
is: CHEBI:17754
constant: false
initial concentration: 1.0
name: Glycerol
type: Species
boundary condition: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: HMDB00131

metaR DOLPH Ler
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
is: SBO:0000176
product: MODEL1310110006#
name: Dolichol-phosphate phosphohydrolase, human (liver)
is described by: ECO:0000000
reactant: MODEL1310110006#
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110006#

metaR CYANtm
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
is described by: ECO:0000000
product: MODEL1310110006#
is: SBO:0000185
reactant: MODEL1310110006#
name: Cyanide transport via diffusion (mitochondrial)
type: Reaction
fast: false
reversible: true

metaR MTHFDm
type: Reaction
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.3.4.3
reactant: MODEL1310110006#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
product: MODEL1310110006#
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD

metaR C51CPT1
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tiglylcarnitine
type: Reaction

metaM HC00900 m
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
is: SBO:0000247
name: Methylmalonate
constant: false
is: CHEBI:30860

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

metaM ksi pre18 g
boundary condition: false
has only substance units: false
constant: false
type: Species
is: HMDB00175
is: CHEBI:58053
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 18
is: C00130
is: SBO:0000247
notes: FORMULA: C163H262N11O132S5X CHARGE: -6

metaR ACACT10m
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
type: Reaction
reversible: true
reactant: MODEL1310110006#
is: SBO:0000176
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.9
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000134
fast: false

metaM lys L c
is: SBO:0000247
type: Species
is: CHEBI:32551
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
name: L-lysinium(1+)
has only substance units: false
constant: false

metaM acgam l
constant: false
boundary condition: false
name: N-acetyl-D-glucosamine
is: SBO:0000247
type: Species
is: HMDB00215
is: CHEBI:17411
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140

http://identifiers.org/biomodels.db/MODEL1310110006#_7074b04d_b33a_479d_abb3_9e226b645def
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:8310
name: ACOX3
is: O15254
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_2bae8067_22de_442b_b252_29ec8233c875
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: EARS2
constant: false
has only substance units: false
is: Q5JPH6
type: Species
is encoded by: hsa:124454

metaR r2125
reversible: true
kinetic law: MODEL1310110006#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110006#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110006#
fast: false

metaM HC01406 m
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
constant: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:28264
initial concentration: 1.0
name: 3-Oxooctanoyl-CoA
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_6db66cfd_42e0_4a92_a519_05dbe6c56783
name: ALDH3B1
is: P43353
is encoded by: hsa:221
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_e
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00143
initial concentration: 1.0
is: CHEBI:0
has only substance units: false
is: C00124
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_ffcf5e2e_8048_4dd9_ad39_a38d6f0e080d
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ENPP1
is: P22413
is encoded by: hsa:5167
initial amount: NaN

metaR IVCRNe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

metaM f26bp c
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01047
initial amount: NaN
is: CHEBI:58579
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-2-6(18-20(13,14)15)5(9)4(8)3(17-6)1-16-19(10,11)12/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4-,5+,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00484 EHMN_ABBREVIATION: C00665
name: beta-D-fructofuranose 2,6-bisphosphate(4-)

metaM m6masnC g
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C58H97N2O45X CHARGE: 0
type: Species
is: CHEBI:30825
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00573
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

http://identifiers.org/biomodels.db/MODEL1310110006#_2510486d_b748_48e2_b692_a32a2a0a413d
boundary condition: true
initial concentration: NaN
type: Species
name: _AI971036_1_m
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI971036

metaM sql r
is: SBO:0000247
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
boundary condition: false
is: HMDB00256
initial concentration: 1.0
is: CHEBI:15440
constant: false
initial amount: NaN
type: Species
name: squalene
has only substance units: false

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM 3docopencoa x
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
initial concentration: 1.0
type: Species
name: 3,7,10,13,16-docosapentenoylcoa

metaR r1018
reversible: true
is described by: ECO:0000000
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
kinetic law: MODEL1310110006#
fast: false
type: Reaction
name: Transport reaction
is: SBO:0000185
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_761652b3_03d5_4084_9b84_ec3f37eee91b
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: KHK
is: Q6IBK2
has only substance units: false
is encoded by: hsa:3795
initial amount: NaN
type: Species
constant: false

metaR r2124
is: SBO:0000185
modifier: MODEL1310110006#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110006#
type: Reaction
fast: false
reactant: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#

metaR ALADGLYexR
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110006#
name: D-alanine/glycine reversible exchange
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110006#_4087b294_98fd_48ad_8102_203723f569d8
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:4881
constant: false
name: NPR1
boundary condition: true
is: P16066
initial concentration: NaN
has only substance units: false

metaM pan4p m
initial concentration: 1.0
initial amount: NaN
name: pantetheine 4'-phosphate(2-)
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB01416
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_3c69802a_785f_4ffa_a346_a53508c51253
has part: Q96RQ3
boundary condition: true
is: SBO:0000297
initial amount: NaN
name: MCCC1:MCCC2
has only substance units: false
is encoded by: hsa:56922
initial concentration: NaN
constant: false
has part: Q9HCC0
is encoded by: hsa:64087
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_468398a5_6ce2_438e_accc_b1a584cd2aa9
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:5335
name: PLCG1
type: Species
is: P19174
initial amount: NaN
is: SBO:0000252

metaM glyc c
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C00116
boundary condition: false
name: Glycerol
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
constant: false
is: CHEBI:17754
is: HMDB00131
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_80949d50_319a_4a8f_9766_adbfff9b7b31
type: Species
is: B4E1R2
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1491
constant: false
name: CTH
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_c
type: Species
initial amount: NaN
is: HMDB00143
is: SBO:0000247
notes: FORMULA: C96H165N4O60FULLRCO CHARGE: 0
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:12936
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1

http://identifiers.org/biomodels.db/MODEL1310110006#_289c093a_008a_4fe1_9e32_5c5cc18656ec
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:6531
name: SLC6A3
is: Q01959
has only substance units: false
is: SBO:0000252

metaM cit e
initial amount: NaN
constant: false
is: SBO:0000247
name: citrate(3-)
is: CHEBI:16947
initial concentration: 1.0
is: HMDB00094
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158

metaR ALAtN1
type: Reaction
product: MODEL1310110006#
is: SBO:0000185
reactant: MODEL1310110006#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110006#
name: Alanine transport (Na, H coupled)
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reversible: true

metaM nadp r
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
is: HMDB00217
initial concentration: 1.0
constant: false
is: CHEBI:58349
type: Species
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate
has only substance units: false
is: C00006
boundary condition: false

metaR r0842
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
fast: false
type: Reaction
reversible: true
product: MODEL1310110006#
is: SBO:0000185
kinetic law: MODEL1310110006#
name: Postulated transport reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110006#

metaR r1019
kinetic law: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
name: Postulated transport reaction
reactant: MODEL1310110006#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:

metaR UMPK7n
fast: false
type: Reaction
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dGTP),nuclear
is described by: ECO:0000269
product: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM focytC m
has only substance units: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
is: CHEBI:16928
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
name: Ferrocytochrome C
boundary condition: false
initial amount: NaN

metaR r2123
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
modifier: MODEL1310110006#
product: MODEL1310110006#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110006#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_5b1a6c5c_b1dd_4040_adca_a34f40da9330
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM na1 e
is: HMDB00588
initial amount: NaN
boundary condition: false
is: CHEBI:4541
is: C01330
has only substance units: false
type: Species
name: Sodium
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: Na CHARGE: 1

metaR CHOLESTle
type: Reaction
is described by: ECO:0000134
fast: false
product: MODEL1310110006#
name: hydrolysis of cholesterol ester by cholesterol esterase
reversible: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.13
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#

metaM s2l2fn2m2masn e
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: HMDB00244
initial amount: NaN
name: PA6
type: Species
has only substance units: false
constant: false
is: C00255
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:3554
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_f187e684_1db7_4f21_93a1_ae6595ae1aaa
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: CDO1
is: Q16878
is encoded by: hsa:1036

http://identifiers.org/biomodels.db/MODEL1310110006#_466b3c29_3bd4_4179_930d_fb594a287771
name: EGFR
initial amount: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:1956
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P00533

http://identifiers.org/biomodels.db/MODEL1310110006#_c5b10d8e_c511_4561_94d4_a9dc4257a3e8
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q96QE2
is: SBO:0000252
name: SLC2A13
type: Species
is encoded by: hsa:114134
has only substance units: false
constant: false

metaR r0841
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
is: SBO:0000185
reactant: MODEL1310110006#
name: Free diffusion
type: Reaction
reversible: true
modifier: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.1.1.271
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_39756b6b_dd9d_441a_a981_29256de7ac27
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: RDH13
initial concentration: NaN
type: Species
is encoded by: hsa:112724
is: B3KVA3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_531f78fb_575a_4ef3_8ab7_ad58906058a6
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:22305
boundary condition: true
name: _22305_2_c
is: SBO:0000252
type: Species
constant: false

metaR PHEMEt
type: Reaction
name: heme transport
modifier: MODEL1310110006#
reactant: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
kinetic law: MODEL1310110006#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110006#_d51ceb8c_ecde_414d_9ef1_247dd937267f
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: O14521
name: SDHD
is: SBO:0000252
is encoded by: hsa:6392
initial amount: NaN
constant: false

metaR FACOAL245 2
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110006#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000269
fast: false
type: Reaction
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

metaR FAOXC123x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_78f18464_51fe_400d_922e_9404d3edb6e7
has only substance units: false
is: Q969K7
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:113452
initial concentration: NaN
name: TMEM54

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR r2122
reactant: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110006#

metaM C02470 c
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
has only substance units: false
is: http://identifiers.org/pubchem.compound/5485
type: Species
is: C02470
is: SBO:0000247
initial concentration: 1.0
name: Xanthurenic acid
is: HMDB00881

metaM acglcgalgluside hs g
is: CHEBI:17103
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0

metaM cdp m
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
type: Species
is: CHEBI:58069
constant: false
initial amount: NaN
name: CDP(3-)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR 4MOPte
reactant: MODEL1310110006#
name: Transport of 4-methyl-2-oxopentanoate
kinetic law: MODEL1310110006#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110006#
type: Reaction
is described by: ECO:0000134
fast: false

metaM acgbgbside hs l
name: beta GalNAc globoside
is: CHEBI:17411
constant: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
is: HMDB00215
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR ADPT
notes: GENE_ASSOCIATION: (353.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.7 Confidence Level: 4 AUTHORS: PMID:14674717,PMID:15196008 NOTES:
product: MODEL1310110006#
is: SBO:0000176
fast: false
modifier: MODEL1310110006#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.2.7
name: adenine phosphoribosyltransferase
kinetic law: MODEL1310110006#

metaM cit c
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
name: Citrate
is: C00158
is: HMDB00094
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:16947
is: SBO:0000247

metaM 3hexdtetcoa x
initial concentration: 1.0
type: Species
is: HMDB02288
name: 3,7,10,13-hexadecatetraenoylcoa
constant: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR MANtly
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
fast: false
is described by: ECO:0000000
reactant: MODEL1310110006#
is: SBO:0000185
product: MODEL1310110006#
name: mannose efflux from lysosome

metaR r2121
modifier: MODEL1310110006#
product: MODEL1310110006#
reversible: true
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR SERt4
reversible: false
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
modifier: MODEL1310110006#
is: SBO:0000185
fast: false
name: L-serine via sodium symport
kinetic law: MODEL1310110006#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110006#
product: MODEL1310110006#

metaR ACCOAC
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaR FACOAL245 1
kinetic law: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
modifier: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000176
reversible: true
name: fatty-acid--CoA ligase

metaM na1 c
type: Species
is: CHEBI:4541
initial amount: NaN
name: Sodium
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00588
is: C01330
notes: FORMULA: Na CHARGE: 1

metaM tststerone c
is: SBO:0000247
is: HMDB00234
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
has only substance units: false
is: CHEBI:17347
name: testosterone
boundary condition: false

metaR FAOXC123C102x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)x
type: Reaction

metaM cdp n
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01546
is: CHEBI:58069
boundary condition: false
name: CDP(3-)

http://identifiers.org/biomodels.db/MODEL1310110006#_ea302a0e_c1f6_4745_aa7c_78ff65de0bb1
name: NAGK
type: Species
is encoded by: hsa:55577
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q9UJ70
initial amount: NaN

metaM mlthf c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: C00143
is: CHEBI:15636
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: HMDB01533
initial amount: NaN
has only substance units: false
type: Species
name: 5,10-Methylenetetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110006#_36e17475_6023_4634_9e23_1fc59a12900b
type: Species
has only substance units: false
initial amount: NaN
name: ADO
is encoded by: hsa:84890
constant: false
initial concentration: NaN
boundary condition: true
is: B3KXN9
is: SBO:0000252

metaR TETDEC2CRNe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_da087f80_bde2_4a07_b63a_2b6fbe1caf29
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:2582
is: Q14376
name: GALE
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false

metaM 3otdcoa m
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:28726
name: 3-Oxotetradecanoyl-CoA
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
is: HMDB03935
initial concentration: 1.0

metaR r2120
is described by: ECO:0000000
fast: false
reactant: MODEL1310110006#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110006#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#

metaR FAOXC81C61x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_dc5a5faf_652b_4c11_ac2f_4055deb9f8aa
is encoded by: hsa:766
name: CA7
constant: false
is: P43166
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM retinol cis 11 c
constant: false
initial amount: NaN
type: Species
is: CHEBI:16302
has only substance units: false
name: 11-cis-retinol
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial concentration: 1.0
is: HMDB06216

http://identifiers.org/biomodels.db/MODEL1310110006#_e78ccd92_9b99_4832_8788_43fe392f2e3f
initial concentration: NaN
boundary condition: true
is: P21912
is: SBO:0000252
has only substance units: false
name: SDHB
constant: false
type: Species
is encoded by: hsa:6390
initial amount: NaN

metaR r1907
product: MODEL1310110006#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110006#
is described by: ECO:0000000
reversible: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_000c52aa_c560_460e_8eaf_cbe6db0b3064
is encoded by: hsa:4047
is: E9PEI9
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: LSS

metaM 3pg m
is: SBO:0000247
is: HMDB00807
constant: false
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
is: CHEBI:58272
has only substance units: false

metaR GLXtp
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
reversible: true
is described by: ECO:0000000
name: glyoxylate transport, peroxisomal
kinetic law: MODEL1310110006#
is: SBO:0000185
product: MODEL1310110006#
type: Reaction
fast: false

metaM tetdec2crn e
name: tetradecadienoyl carnitine
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C21H37NO4 CHARGE: 0
initial amount: NaN
is: HMDB05066

metaM cs e deg2 l
has only substance units: false
constant: false
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
is: HMDB01354
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:57455

metaR r2128
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110006#
is described by: ECO:0000000

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_7188c47a_feb5_410b_849d_b417e83f1865
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:4717
is: SBO:0000252
boundary condition: true
has only substance units: false
name: NDUFC1
initial amount: NaN
is: O43677

metaR VACCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110006#
reversible: true
is described by: ECO:0000000
type: Reaction
name: fatty acid transport via diffusion
reactant: MODEL1310110006#
is: SBO:0000185
kinetic law: MODEL1310110006#
fast: false

metaM tetdec2crn c
initial concentration: 1.0
is: HMDB02014
has only substance units: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C21H37NO4 CHARGE: 0
initial amount: NaN
name: tetradecadienoyl carnitine
boundary condition: false

metaM paf hs c
constant: false
type: Species
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
is: CHEBI:36707
initial amount: NaN
has only substance units: false
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM HC01434 x
is: CHEBI:58931
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
name: oxalatosuccinate(3-)
has only substance units: false
constant: false
initial amount: NaN
type: Species

metaM 34dhoxmand m
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB01866
constant: false
is: CHEBI:27637
name: 3,4-Dihydroxymandelate

http://identifiers.org/biomodels.db/MODEL1310110006#_d4debd4b_8376_4ce8_9ced_250db6288a55
name: CH25H
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9023
type: Species
is: O95992
constant: false

metaM uri e
initial amount: NaN
is: C00299
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00296
initial concentration: 1.0
name: Uridine
is: CHEBI:16704
constant: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
type: Species

metaR r2129
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110006#
is described by: ECO:0000000
modifier: MODEL1310110006#

metaM retinol cis 11 e
constant: false
initial amount: NaN
type: Species
is: CHEBI:16302
is: SBO:0000247
is: HMDB06216
name: 11-cis-retinol
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
has only substance units: false

metaR RE2659R
product: MODEL1310110006#
reversible: true
fast: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
is described by: ECO:0000000
name: RE2659

metaM hs deg1 l
is: HMDB01352
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: heparan sulfate, degradation product 1
boundary condition: false
type: Species
is: CHEBI:17180
constant: false
is: SBO:0000247

metaM hexdtrcoa m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
is: HMDB02288
name: 7,10,13-hexadecatrienoylcoa
constant: false

metaR DLNLCGt
is: SBO:0000185
kinetic law: MODEL1310110006#
name: fatty acid transport via diffusion
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
product: MODEL1310110006#
reversible: true
is described by: ECO:0000000
type: Reaction

metaR HS4ly
reversible: false
modifier: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
name: heparan-N-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
product: MODEL1310110006#
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.10.1.1

metaM 3octdece1crn c
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C25H47NO5 CHARGE: 0
initial concentration: 1.0
name: 3-hydroxy-octadecenoyl carnitine
is: HMDB13336
boundary condition: false
constant: false

metaR SEBACIDTD
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaR MM5ag
product: MODEL1310110006#
type: Reaction
reversible: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.113
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is: SBO:0000176

metaM ksi deg13 l
name: keratan sulfate I, degradation product 13
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:57455
initial amount: NaN
type: Species
is: HMDB01354
initial concentration: 1.0
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
constant: false

metaM 4abutn m
is: HMDB01080
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: 4-ammoniobutanal
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: CHEBI:58264

metaM q10 m
is: HMDB01072
boundary condition: false
is: CHEBI:46245
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial concentration: 1.0
name: ubiquinone-10
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_2711414d_15d0_43b6_8857_784c300cad01
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PRDX1
has only substance units: false
constant: false
is encoded by: hsa:5052
initial concentration: NaN

metaR RDH2a
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.1.1.105
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
kinetic law: MODEL1310110006#
fast: false
modifier: MODEL1310110006#
is described by: ECO:0000269
name: retinol dehydrogenase (9-cis,NADPH)
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.300
is: SBO:0000176
reversible: true

metaR HDDACBP
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR GLXtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
name: glyoxylate transport, mitochondrial
product: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_e814febe_85b2_46ca_b779_87ce08561b55
initial amount: NaN
type: Species
has only substance units: false
is: O00330
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:8050
name: PDHX
is: SBO:0000252

metaR r0062
is described by: ECO:0000000
modifier: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
name: Acetyl-CoA hydrolase Pyruvate metabolism EC:3.1.2.1
is version of: http://identifiers.org/ec-code/4.3.1.17
type: Reaction
fast: false
kinetic law: MODEL1310110006#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.1 Confidence Level: 0 AUTHORS: PMID:11322891,PMID:12545200,PMID:16951743,PMID:34392,PMID:6151837,PMID:7696329 NOTES:

metaM uri c
type: Species
boundary condition: false
is: C00299
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Uridine
initial concentration: 1.0
is: HMDB00296
is: CHEBI:16704
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
constant: false

metaM paf hs e
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
type: Species
is: CHEBI:36707
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
initial concentration: 1.0
initial amount: NaN

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaR IDOAASE2ly
reactant: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
name: alpha-L-iduronidase, lysosomal
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.76
fast: false
modifier: MODEL1310110006#

metaM 3sala m
is: C00606
is: CHEBI:61085
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
initial concentration: 1.0
name: 3-sulfino-L-alanine (1-)

metaR SEBCOAPET
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaR C4STMO1r
type: Reaction
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
reactant: MODEL1310110006#
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
modifier: MODEL1310110006#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.72
product: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_2d8b1f5c_c861_467e_8981_3670512c26a3
constant: false
is: P04844
name: RPN2
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6185
boundary condition: true

metaR EX CE5867 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartyl-lysyl-proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_2261c3a1_454d_4523_a680_18137ee13217
is encoded by: hsa:6241
initial concentration: NaN
is: P31350
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: RRM2
has only substance units: false
constant: false

metaR EX 34hpp
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_f48aecf3_5efe_41e7_8b54_9e10f30bbb40
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:218
initial concentration: NaN
has only substance units: false
name: ALDH3A1
is: P30838
boundary condition: true

metaR RE3050R
reactant: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
reversible: true
product: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: RE3050
type: Reaction

metaM 3octdece1crn e
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H47NO5 CHARGE: 0
name: 3-hydroxy-octadecenoyl carnitine
constant: false
initial concentration: 1.0
type: Species
is: HMDB13336

http://identifiers.org/biomodels.db/MODEL1310110006#_da2d4bb3_7765_42ad_94a5_21108aaa4dfb
is: SBO:0000252
has only substance units: false
boundary condition: true
name: NDUFA11
initial amount: NaN
is: C9JT23
is encoded by: hsa:126328
type: Species
initial concentration: NaN
constant: false

metaR HSD17B42x
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
type: Reaction
modifier: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
name: hydroxysteroid (17-beta) dehydrogenase 4
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110006#_e76ba026_f5ac_4dd1_8d90_f854e89ffa67
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q16875
name: PFKFB3
constant: false
is encoded by: hsa:5209

metaR r1010
type: Reaction
name: Postulated transport reaction
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185
reactant: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
fast: false
reversible: true

metaM ksi l
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial concentration: 1.0
is: CHEBI:57455
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: C00445
is: SBO:0000247
is: HMDB01354
name: keratan sulfate I
has only substance units: false

metaM ksi pre17 g
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
name: keratan sulfate I biosynthesis, precursor 17
is: CHEBI:28067
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_f991b0a8_50c9_4164_a76a_5176796fc14f
boundary condition: true
is encoded by: hsa:27068
has only substance units: false
name: PPA2
is: SBO:0000252
initial amount: NaN
is: F8WDN9
initial concentration: NaN
type: Species
constant: false

metaR RE0453C
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110006#
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110006#
name: RE0453
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_53064337_29e2_4c49_bf29_d7e89617e957
is encoded by: hsa:10246
name: SLC17A2
initial concentration: NaN
has only substance units: false
is: O00624
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_2dd851fd_b858_4b50_a777_adcb66beecb4
is: P28845
boundary condition: true
initial amount: NaN
constant: false
name: HSD11B1
is encoded by: hsa:3290
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_17dfe9f1_3422_48e2_8a4b_543b4ce7c584
initial concentration: NaN
initial amount: NaN
is: O14561
boundary condition: true
is encoded by: hsa:4706
is: SBO:0000252
type: Species
has only substance units: false
constant: false
name: NDUFAB1

http://identifiers.org/biomodels.db/MODEL1310110006#_29df31a6_a101_4fb3_a286_86c17ee9edb2
has only substance units: false
is: O43924
is encoded by: hsa:5147
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: PDE6D
type: Species
is: SBO:0000252
constant: false

metaR G14T16g
is described by: ECO:0000000
reactant: MODEL1310110006#
modifier: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110006#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110006#

metaM leuleu c
is: http://identifiers.org/pubchem.compound/94244
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
name: Leucylleucine
boundary condition: false
notes: FORMULA: C12H24N2O3 CHARGE: 0
initial concentration: 1.0
constant: false

metaR HS1ly
name: heparan-N-sulfatase, lysosomal
fast: false
type: Reaction
modifier: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.10.1.1

metaM akg c
initial concentration: 1.0
name: 2-Oxoglutarate
is: CHEBI:16810
is: SBO:0000247
is: HMDB00208
type: Species
has only substance units: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial amount: NaN
is: C00026
constant: false
boundary condition: false

metaR PRPPS
kinetic law: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
reversible: true
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.6.1
modifier: MODEL1310110006#
reactant: MODEL1310110006#
name: phosphoribosylpyrophosphate synthetase

http://identifiers.org/biomodels.db/MODEL1310110006#_58055a24_332a_4af9_a203_bfc21f675b2f
boundary condition: true
is encoded by: hsa:2544
type: Species
name: _2544_1_c
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaR r1901
reactant: MODEL1310110006#
modifier: MODEL1310110006#
name: Y+LAT2 Utilized transport
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110006#_102a6c3d_918b_40a8_b702_46feae889c15
is: SBO:0000252
type: Species
is: O75106
name: AOC2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:314
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_a1bbffeb_5b88_4d87_af32_32972b7a3544
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:D29675
name: _D29675_1_c
boundary condition: true
has only substance units: false
constant: false

metaM 2oxoadp m
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: HMDB00225
name: 2-oxoadipate(2-)
is: CHEBI:57499
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_efa88398_103f_4187_b7e2_6c5cdee2308e
has only substance units: false
is encoded by: hsa:84264
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: HAGHL
initial amount: NaN

metaR G14T2g
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22

http://identifiers.org/biomodels.db/MODEL1310110006#_b071fff5_3227_4413_8885_6a38fa266d4e
name: PIGB
boundary condition: true
is: Q92521
is: SBO:0000252
is encoded by: hsa:9488
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false

metaR AICART
is version of: http://identifiers.org/ec-code/2.1.2.3
is described by: ECO:0000269
kinetic law: MODEL1310110006#
product: MODEL1310110006#
fast: false
type: Reaction
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
is: SBO:0000176
modifier: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
reversible: true

metaM mi14p c
boundary condition: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:58282
is: SBO:0000247
type: Species
is: HMDB00968
initial concentration: 1.0
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220

http://identifiers.org/biomodels.db/MODEL1310110006#_4cfb90da_95ab_4b6c_a390_8323472b2a91
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4709
initial amount: NaN
has only substance units: false
is: Q6IB80
name: NDUFB3
type: Species
constant: false
boundary condition: true

metaM dhf m
initial concentration: 1.0
name: dihydrofolate(2-)
is: HMDB01056
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
type: Species
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:57451
initial amount: NaN

metaM leuleu e
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
type: Species
name: Leucylleucine
notes: FORMULA: C12H24N2O3 CHARGE: 0
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/94244

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR XYLt
product: MODEL1310110006#
name: D-xylose reversible transport
type: Reaction
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
fast: false
reversible: true

metaM akg e
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: CHEBI:16810
initial concentration: 1.0
is: HMDB00208
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: 2-oxoglutarate(2-)

metaM dhf l
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: HMDB01056
name: dihydrofolate(2-)
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:57451

metaM o2s x
name: superoxide
constant: false
has only substance units: false
is: CHEBI:18421
is: HMDB02168
boundary condition: false
type: Species
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_5a74c428_b65d_4686_b00e_eca6a95590b4
initial concentration: NaN
is encoded by: hsa:6309
name: SC5DL
type: Species
is: Q6GTM5
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_f789798e_a613_4b80_99cb_685b5e8d49d1
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:10026
constant: false
type: Species
has only substance units: false
name: PIGK
boundary condition: true
is: Q92643
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_9b809b78_e265_4445_aaac_8e2638af78ce
name: BDH1
initial amount: NaN
is encoded by: hsa:622
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q02338

http://identifiers.org/biomodels.db/MODEL1310110006#_d99dcf28_b18c_4083_b7b4_38cca35d3373
constant: false
is encoded by: hsa:AI971036
has only substance units: false
name: _AI971036_1_x
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true

metaM mev R c
constant: false
is: HMDB00227
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:36464
boundary condition: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: SBO:0000247
type: Species
name: (R)-mevalonate

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_a0992c0f_d9d1_439d_9472_b5c3144a20c6
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: SLC46A1
is encoded by: hsa:113235
is: Q96NT5
initial amount: NaN
type: Species
boundary condition: true

metaM hexdiac c
name: hexadecanediocacid
is: C08260
has only substance units: false
is: SBO:0000247
is: HMDB00672
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C16H28O4 CHARGE: -2
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_b04b5b35_4b0f_4ed5_859b_1217daa4e8ce
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:50808
initial amount: NaN
type: Species
boundary condition: true
is: E7ET30
name: AK3

metaR ECOAH1m
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/4.2.1.18

metaM CE4872 m
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
constant: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: SBO:0000247
boundary condition: false
is: HMDB00127
has only substance units: false
is: CHEBI:15748
type: Species
initial amount: NaN
initial concentration: 1.0

metaR r1576
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reactant: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ksi g
initial amount: NaN
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: HMDB01644
constant: false
type: Species
name: keratan sulfate I
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:17140

metaR H7MTer U
is: SBO:0000176
reversible: false
type: Reaction
name: H7 mannosyltransferase, endoplasmic reticulum
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (80235.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15208306 NOTES:NCD
modifier: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_33c5ffc2_8269_4d4d_856e_dab53f5b6772
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:11226
is: Q8NCL4
name: GALNT6
boundary condition: true
has only substance units: false
constant: false

metaR H2CO3D
type: Reaction
reversible: true
reactant: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
is version of: http://identifiers.org/ec-code/4.2.1.1
modifier: MODEL1310110006#
fast: false
is described by: ECO:0000000
product: MODEL1310110006#
name: carboxylic acid dissociation

metaM 3pg c
initial concentration: 1.0
is: HMDB00807
has only substance units: false
is: C00197
is: http://identifiers.org/pubchem.compound/3497
is: CHEBI:58272
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: 3-Phospho-D-glycerate
is: SBO:0000247

metaM 4abutn c
is: C00555
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: SBO:0000247
is: CHEBI:58264
name: 4-Aminobutanal
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB01080
type: Species
has only substance units: false
constant: false

metaR C4x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_318fcdea_71b5_4383_829e_5bcfa74ea011
type: Species
name: NDUFC2
is: Q549M5
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:4718

metaR NACHEX8ly
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110006#_7976d0a2_08b8_4b44_91c0_502e9944d3f3
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI480132
name: _AI480132_1_c
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

metaR DM gpi sig er
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_42f0bcdd_372f_4e95_a937_90dfcef57fad
type: Species
has only substance units: false
initial amount: NaN
name: UMPS
is: A8K5J1
is encoded by: hsa:7372
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_2bba8df0_f259_402d_adef_23eaca63bf15
constant: false
type: Species
has only substance units: false
boundary condition: true
name: ATP1A2
is: P50993
is encoded by: hsa:477
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR r1579
fast: false
kinetic law: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaR CHSTEROLt3
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: cholesterol intracellular transport

metaR RE1526M
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reactant: MODEL1310110006#
is: SBO:0000176
modifier: MODEL1310110006#
fast: false
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
is described by: ECO:0000000
name: RE1526
reversible: true

metaM ksi pre1 g
is: CHEBI:58053
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C79H129N5O57X CHARGE: -1
is: C00130
name: keratan sulfate I biosynthesis, precursor 1
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00175

metaM dcyt c
name: Deoxycytidine
is: HMDB00014
initial amount: NaN
boundary condition: false
is: C00881
has only substance units: false
is: CHEBI:15698
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881

metaM acnam c
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:35418
name: N-acetylneuraminate
is: HMDB00230
has only substance units: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270

http://identifiers.org/biomodels.db/MODEL1310110006#_2316d236_d105_4e6c_a606_fd4e3a0dda93
is encoded by: hsa:249
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: B7Z4Y6
name: ALPL

http://identifiers.org/biomodels.db/MODEL1310110006#_2b844174_b1f5_46d7_ba5f_8b3b603b9b85
type: Species
constant: false
name: ALG5
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:29880
is: Q9Y673
is: SBO:0000252
has only substance units: false

metaR FAOXC101C102m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_a8b80cec_b746_46b9_bf8e_5c59cb28a5c6
initial amount: NaN
is encoded by: hsa:AI697028
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: _AI697028_1_e
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_ab8c5360_6eaf_482f_af94_0edcdf9273eb
constant: false
is encoded by: hsa:AI222095
name: _AI222095_1_m
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_889422fa_e99e_4e28_a118_fc9b84ac1052
type: Species
is: O14939
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
name: PLD2
initial amount: NaN
is encoded by: hsa:5338

metaR r1578
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110006#_efc54418_86fd_4fb0_8c49_f0bf16b3d757
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55293
is: Q8IX04
initial concentration: NaN
name: UEVLD
type: Species
initial amount: NaN
has only substance units: false

metaM retinal cis 13 c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB06220
name: 13-cis-retinal
type: Species
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: CHEBI:45487
initial amount: NaN

metaR C12DCTD
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

metaM c12dccoa x
name: dodecanedioylcoa
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: HMDB03712
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR CHSTEROLt2
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110006#
name: cholesterol intracellular transport
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110006#
is: SBO:0000185
reversible: true

metaM 4abutn e
has only substance units: false
name: 4-ammoniobutanal
is: SBO:0000247
initial amount: NaN
is: CHEBI:58264
boundary condition: false
is: HMDB01080
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555

metaR ETF
modifier: MODEL1310110006#
reversible: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
is: SBO:0000176
name: electron transfer flavoprotein
product: MODEL1310110006#
fast: false
type: Reaction

metaM ttdca c
type: Species
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
is: SBO:0000247
name: myristate
is: CHEBI:30807
initial concentration: 1.0
is: HMDB00806
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN

metaR M14NTg
reactant: MODEL1310110006#
reversible: false
name: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
kinetic law: MODEL1310110006#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.144
notes: GENE_ASSOCIATION: (4248.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.144 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
product: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_fc42dc64_8b1c_48a7_af00_dba6ec8073ad
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
name: DPAGT1
is encoded by: hsa:1798
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_3cb0da03_6556_43fc_ade4_cea3b2957b49
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5092
name: PCBD1
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaM hyptaur c
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: HMDB00965
initial amount: NaN
is: CHEBI:16668
boundary condition: false
name: Hypotaurine
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
has only substance units: false

metaR CHSTEROLt1
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
reversible: true
reactant: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000185
modifier: MODEL1310110006#
product: MODEL1310110006#
name: cholesterol intracellular transport
is described by: ECO:0000304
fast: false

metaM man6p c
name: D-Mannose 6-phosphate
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:17369
type: Species
is: HMDB01078
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_c065e126_ae82_49a1_be84_297e34d4aec5
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: P47989
name: XDH
is encoded by: hsa:7498

metaM dhf e
initial amount: NaN
name: dihydrofolate(2-)
is: CHEBI:57451
boundary condition: false
type: Species
is: HMDB01056
constant: false
initial concentration: 1.0
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: SBO:0000247
has only substance units: false

metaR MTHFC
is described by: ECO:0000134
fast: false
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.5.4.9
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
modifier: MODEL1310110006#
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.5
is: SBO:0000176
type: Reaction
product: MODEL1310110006#
kinetic law: MODEL1310110006#
name: methenyltetrahydrofolate cyclohydrolase

http://identifiers.org/biomodels.db/MODEL1310110006#_ecbb57b4_5b95_4f64_84e2_787150e9a1e5
initial amount: NaN
is: Q8N9L9
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:122970
boundary condition: true
has only substance units: false
name: ACOT4

metaR r1573
type: Reaction
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR FACOAL160i
product: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
name: C160 fatty acid activation
reversible: false
kinetic law: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM glyclt x
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:29805
type: Species
is: SBO:0000247
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
is: HMDB00115
name: glycolate

metaM c6dc c
boundary condition: false
is: SBO:0000247
is: HMDB00705
constant: false
name: adipoyl carnitine
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C13H22NO6 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110006#_aac8c3a9_520f_4086_a60b_ace2b1220104
initial amount: NaN
boundary condition: true
is encoded by: hsa:57134
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q9NR34
name: MAN1C1
type: Species
constant: false

metaM spmd e
is: SBO:0000247
is: C00315
constant: false
is: HMDB01257
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
boundary condition: false
is: CHEBI:57834
name: Spermidine
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0

metaM ksi pre30 g
name: keratan sulfate I biosynthesis, precursor 30
boundary condition: false
is: SBO:0000247
is: C00130
is: HMDB00175
is: CHEBI:58053
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_7a69cbdd_26c5_469d_9d4c_fc3bf6a66d56
is: P78381
is: SBO:0000252
name: SLC35A2
is encoded by: hsa:7355
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
constant: false

metaR PCt
is version of: http://identifiers.org/ec-code/3.6.3.44
kinetic law: MODEL1310110006#
is: SBO:0000185
reactant: MODEL1310110006#
product: MODEL1310110006#
modifier: MODEL1310110006#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
name: phosphatidylcholine transporter
fast: false
is described by: ECO:0000269

metaR r1443
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
product: MODEL1310110006#
is described by: ECO:0000000
name: EC:1.3.3.6
type: Reaction
reversible: false
kinetic law: MODEL1310110006#
is: SBO:0000176
fast: false
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_08420d88_9996_4e44_b318_c48ed0170c05
has only substance units: false
is encoded by: hsa:AI694761
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: _AI694761_1_c

http://identifiers.org/biomodels.db/MODEL1310110006#_546e3148_bcda_4058_9374_8d330646b822
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SI
constant: false
is: P14410
is encoded by: hsa:6476
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_f2bef2ea_68ad_4360_a59c_18c042bac6d5
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:50
type: Species
has only substance units: false
initial amount: NaN
is: Q99798
name: ACO2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_19504390_1fd3_41e7_bd4b_2fe840caacfd
is: SBO:0000297
has part: P50993
is encoded by: hsa:477
type: Species
boundary condition: true
is encoded by: hsa:23439
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ATP1B4:ATP1A2
has part: Q9UN42
constant: false

metaM ksii core4 pre9 g
is: CHEBI:28067
boundary condition: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 9
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM hs deg20 l
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:16126
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
name: heparan sulfate, degradation product 20
type: Species
is: SBO:0000247

metaM ttdca e
name: tetradecanoate (n-C14:0)
constant: false
type: Species
has only substance units: false
is: CHEBI:30807
boundary condition: false
is: HMDB00806
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
is: C06424

http://identifiers.org/biomodels.db/MODEL1310110006#_3faa2db3_bf2e_47db_b313_5e783f43982e
has only substance units: false
initial amount: NaN
is encoded by: hsa:8813
name: DPM3:DPM1:DPM2
is encoded by: hsa:8818
initial concentration: NaN
constant: false
has part: O60762
is: SBO:0000297
has part: O94777
has part: Q86TM7
type: Species
is encoded by: hsa:54344
boundary condition: true

metaR ADAe
reactant: MODEL1310110006#
reversible: false
fast: false
kinetic law: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.5.4.4
is described by: ECO:0000269
name: Adenosine deaminase, extracellular
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
product: MODEL1310110006#
is: SBO:0000176

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_c7b1c1bb_c2e3_4b74_b578_3505670de387
initial amount: NaN
is encoded by: hsa:9498
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
is: E7EML0
name: SLC4A8
initial concentration: NaN
constant: false

metaR ILEt5m
reversible: true
is: SBO:0000185
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reactant: MODEL1310110006#
name: Isoleucine mitochondrial transport
type: Reaction
fast: false

metaR r1575
is: SBO:0000185
reactant: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110006#

metaR GACPAILter
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: false
name: glucosaminyl-acylphosphatidylinositol ER flippase
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM dhf c
constant: false
has only substance units: false
is: CHEBI:57451
is: SBO:0000247
initial amount: NaN
name: 7,8-Dihydrofolate
is: C00415
initial concentration: 1.0
is: HMDB01056
boundary condition: false
type: Species
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415

metaR r1446
reversible: false
reactant: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
fast: false
name: EC:1.3.3.6

metaM spmd c
constant: false
is: HMDB01257
initial amount: NaN
is: CHEBI:57834
has only substance units: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
type: Species
is: C00315
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: Spermidine

metaR TRPHYDRO2
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.14.16.4
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
product: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
is: SBO:0000176
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)

metaR ALADGLNexR
is described by: ECO:0000304
name: L-alanine/glutamine reversible exchange
fast: false
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction

metaR RE0453N
product: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
reversible: true
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: RE0453
is described by: ECO:0000000
reactant: MODEL1310110006#

metaR G6Pter
is described by: ECO:0000269
type: Reaction
product: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
is: SBO:0000185
reversible: true
modifier: MODEL1310110006#
reactant: MODEL1310110006#
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD

metaM ksi e
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:17268
is: SBO:0000247
name: keratan sulfate I
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00211
notes: FORMULA: C247H393N17O213S12X CHARGE: -13

metaR MTHFD
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
fast: false
name: methylenetetrahydrofolate dehydrogenase (NADP)
modifier: MODEL1310110006#
reversible: true
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.5.1.5
reactant: MODEL1310110006#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110006#

metaR MM6bg
is version of: http://identifiers.org/ec-code/3.2.1.113
product: MODEL1310110006#
modifier: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
type: Reaction
kinetic law: MODEL1310110006#
reversible: false

metaR M4MPDOL Lter
reactant: MODEL1310110006#
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110006#
fast: false
name: m4mpdol flippase
product: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110006#_5ba54492_584e_4427_adef_83e7336c5d36
initial concentration: NaN
type: Species
is: P28331
is encoded by: hsa:4719
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: NDUFS1
is: SBO:0000252

metaR r1574
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR DM oretn n
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 4-oxo-retonoic acid demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_2dc6bac8_84d0_4777_ae98_894dca1c9b2e
has only substance units: false
name: NDUFS7
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:374291
is: O75251

metaR RE0453M
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
name: RE0453
fast: false
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000000
reactant: MODEL1310110006#
reversible: true

metaR r0812
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false
type: Reaction
modifier: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#

metaM acnam l
is: HMDB00230
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: CHEBI:35418
name: N-acetylneuraminate
type: Species
is: SBO:0000247
initial amount: NaN

metaM o2s n
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
name: superoxide
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18421
constant: false
is: HMDB02168

metaR FACOAL1821
type: Reaction
is described by: ECO:0000269
reversible: true
name: fatty-acid--CoA ligase
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
fast: false
product: MODEL1310110006#
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110006#

metaR GLYCLTtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
name: glycolate transport into peroxisome
fast: false
is: SBO:0000185
product: MODEL1310110006#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110006#_6f9724f9_bf77_496d_b222_518d2efc5b6a
boundary condition: true
is: Q8TCD5
is: SBO:0000252
initial amount: NaN
name: NT5C
type: Species
is encoded by: hsa:30833
has only substance units: false
initial concentration: NaN
constant: false

metaM CE5586 c
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
boundary condition: false
is: CHEBI:58732
has only substance units: false

metaR SUCCTD
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM xoldiolone r
constant: false
is: HMDB02197
is: CHEBI:28477
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
type: Species
has only substance units: false

metaR r1580
is described by: ECO:0000000
product: MODEL1310110006#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185

metaR C60CPT1
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexanoylcarnitine
type: Reaction

metaR FACOAL1822
reactant: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110006#
reversible: true
is described by: ECO:0000269
product: MODEL1310110006#

metaM udpgal g
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: HMDB00302
type: Species
is: CHEBI:58439
name: UDP-D-galactose(2-)
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_1be7e191_692d_4aa4_bc00_d482c9623a99
is encoded by: hsa:51227
boundary condition: true
name: PIGP
initial concentration: NaN
initial amount: NaN
constant: false
is: P57054
type: Species
has only substance units: false
is: SBO:0000252

metaM c4crn x
is: C02862
has only substance units: false
is: http://identifiers.org/pubchem.compound/213144
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C11H21NO4 CHARGE: 0
name: butyryl carnitine
constant: false
is: HMDB02013
is: SBO:0000247

metaM cmp c
is: HMDB00095
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:60377
constant: false
is: SBO:0000247
name: CMP
is: C00055
has only substance units: false
type: Species

metaM co2 c
is: C00011
boundary condition: false
initial amount: NaN
is: CHEBI:3313
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0
name: CO2
is: HMDB01967
has only substance units: false
type: Species

metaR r1581
reactant: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM Sfglutth c
constant: false
initial amount: NaN
is: CHEBI:57688
initial concentration: 1.0
boundary condition: false
name: S-formylglutathionate(1-)
type: Species
has only substance units: false
is: HMDB01550
is: SBO:0000247
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031

metaR MALTe
reactant: MODEL1310110006#
modifier: MODEL1310110006#
name: alpha-glucosidase, extracellular
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.20
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
kinetic law: MODEL1310110006#

metaM ksi deg36 l
is: SBO:0000247
is: HMDB00143
initial concentration: 1.0
initial amount: NaN
is: CHEBI:12936
type: Species
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
has only substance units: false
boundary condition: false
name: keratan sulfate I, degradation product 36
constant: false

metaM c6crn c
notes: FORMULA: C13H25NO4 CHARGE: 0
is: HMDB00705
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: hexanoyl carnitine
is: SBO:0000247
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_cd2ac7be_17af_4acc_b819_417501033a3f
name: PLD1
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5337
initial amount: NaN
is: Q59EA4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_9c4f99cd_3c43_48e0_9233_9fbf9f3b04d3
boundary condition: true
initial amount: NaN
is: B2RDU6
is: SBO:0000252
is encoded by: hsa:4598
has only substance units: false
constant: false
initial concentration: NaN
type: Species
name: MVK

metaM itacon m
has only substance units: false
is: CHEBI:17240
initial concentration: 1.0
name: itaconate(2-)
is: HMDB02092
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_5c1057aa_8345_4f4c_b9de_668192c8cb55
boundary condition: true
initial amount: NaN
type: Species
name: NIT2
is: SBO:0000252
has only substance units: false
is: Q9NQR4
is encoded by: hsa:56954
initial concentration: NaN
constant: false

metaM dcdp c
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: C00705
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:58593
boundary condition: false
is: HMDB01245
name: dCDP

metaR C141ACBP
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradecenoyl coa from mitochondria into cytosol
type: Reaction

metaR r1796
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110006#
reactant: MODEL1310110006#
name: Y+LAT2 Utilized transport

metaR FAOXC122m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaR PDE1
is version of: http://identifiers.org/ec-code/3.1.4.17
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
is described by: ECO:0000269
fast: false
reversible: false
product: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.4.35
reactant: MODEL1310110006#
name: 3',5'-cyclic-nucleotide phosphodiesterase
kinetic law: MODEL1310110006#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_57e7019d_24bd_4461_864b_98ef8b49d74f
boundary condition: true
initial concentration: NaN
is encoded by: hsa:52
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: ACP1
is: P24666

http://identifiers.org/biomodels.db/MODEL1310110006#_688282c5_e989_41fa_807f_c17e888d52e1
name: GBA
has only substance units: false
constant: false
is encoded by: hsa:2629
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species

metaM m4masn g
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: C05881
notes: FORMULA: C46H77N2O35X CHARGE: 0
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
initial amount: NaN

metaM o2s m
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
type: Species
initial concentration: 1.0
is: C00704
is: HMDB02168
name: Superoxide anion
initial amount: NaN
is: SBO:0000247
is: CHEBI:18421
boundary condition: false
constant: false

metaM cholcoaone x
type: Species
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
constant: false
boundary condition: false
is: SBO:0000247
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
initial amount: NaN
is: HMDB06891
has only substance units: false
initial concentration: 1.0
is: CHEBI:58507

metaM cmp e
initial amount: NaN
name: CMP(2-)
type: Species
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:60377
is: HMDB00095

metaM co2 e
is: CHEBI:16526
initial amount: NaN
is: C00011
is: HMDB01967
type: Species
name: CO2
initial concentration: 1.0
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false

metaM fe2 c
initial amount: NaN
is: C00023
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
type: Species
is: HMDB00692
name: Fe2+
is: CHEBI:29033
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
has only substance units: false

metaR r1583
reactant: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
product: MODEL1310110006#
kinetic law: MODEL1310110006#

metaM mi14p n
has only substance units: false
boundary condition: false
type: Species
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
is: HMDB00968
initial amount: NaN
is: CHEBI:58282
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220

http://identifiers.org/biomodels.db/MODEL1310110006#_447e0805_df2a_456d_929b_41c497713d3e
is: SBO:0000252
constant: false
initial amount: NaN
name: OXSM
initial concentration: NaN
is: Q9NWU1
is encoded by: hsa:54995
boundary condition: true
has only substance units: false
type: Species

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaM rbt e
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: D-ribitol
is: CHEBI:15963
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
is: HMDB00508
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_e3a213e4_352b_478a_b852_9bab342142ca
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q99714
boundary condition: true
name: HSD17B10
is encoded by: hsa:3028
initial amount: NaN
has only substance units: false
type: Species

metaM apoC m
is: SBO:0000247
boundary condition: false
has only substance units: false
name: Apocarboxlase (no lys residue)
initial amount: NaN
is: HMDB00182
is: CHEBI:32551
type: Species
notes: FORMULA: XH CHARGE: 0
constant: false
initial concentration: 1.0

metaR NADPtru
reactant: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
name: NADP transporter, endoplasmic reticulum
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_64f801ae_f0fc_493c_a41d_0ab097c916e4
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
name: _AI539321_1_c
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI539321

metaR RE3243R
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reversible: true
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
fast: false
modifier: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
name: RE3243

http://identifiers.org/biomodels.db/MODEL1310110006#_c2158c98_3e95_4fd2_a48e_274fda15766d
is encoded by: hsa:5160
initial concentration: NaN
has only substance units: false
name: PDHA1
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: P08559
is: SBO:0000252

metaM doldp L r
is: CHEBI:15750
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C1080H1758O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: Dolichol diphosphate, human liver homolog
constant: false

metaM doco13ac e
initial amount: NaN
is: HMDB02068
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C22H41O2 CHARGE: -1
initial concentration: 1.0
name: docosenoic acid (C22:1)
type: Species
is: SBO:0000247

metaM 34dhpha c
is: SBO:0000247
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01336
is: CHEBI:17612
name: (3,4-dihydroxyphenyl)acetate
type: Species
initial amount: NaN

metaM udpgal c
name: UDP-D-galactose(2-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: HMDB00302
is: CHEBI:58439
type: Species

metaR NDPK4n
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
product: MODEL1310110006#
is: SBO:0000176
type: Reaction
fast: false
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
is described by: ECO:0000304
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus

http://identifiers.org/biomodels.db/MODEL1310110006#_0acea7b8_d664_4221_b56c_13538cd4f275
has part: A7E2E0
is encoded by: hsa:8503
type: Species
constant: false
boundary condition: true
name: PIK3CD:PIK3R3
is encoded by: hsa:5293
has part: Q92569
has only substance units: false
is: SBO:0000297
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_bc6df3d5_7b48_4168_a7cb_43e94c381094
is: P83881
is encoded by: hsa:6173
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: RPL36A
boundary condition: true
initial concentration: NaN
constant: false
type: Species

metaR r0960
reactant: MODEL1310110006#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110006#
fast: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_d76ebac3_1291_43f7_b3a7_84cc63696f26
initial concentration: NaN
type: Species
is: P42765
constant: false
boundary condition: true
is encoded by: hsa:10449
name: ACAA2
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_6c8a7038_b7d8_4dab_a2b5_35e9da3414ea
is: SBO:0000252
initial amount: NaN
type: Species
is: Q5VYT2
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4712
name: NDUFB6
constant: false

metaM fe2 e
constant: false
boundary condition: false
is: SBO:0000247
is: C00023
is: HMDB00692
initial concentration: 1.0
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
is: CHEBI:29033
name: Fe2+
has only substance units: false
initial amount: NaN
type: Species

metaM sphs1p r
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
constant: false
is: CHEBI:60119
is: HMDB00277
name: sphingosine 1-phosphate(1-)

http://identifiers.org/biomodels.db/MODEL1310110006#_98aa3d9a_85e9_4843_a643_91a856b6cebd
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: _AI761708_1_m
is encoded by: hsa:AI761708
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR HEXDICOAACBP
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

metaR FAOXC204C205x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

metaR XYLTD Dr
is: SBO:0000176
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110006#
name: xylitol dehydrogenase (D-xyulose-forming)
fast: false
reactant: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
type: Reaction

metaR C8DCc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

metaM r1p c
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
is: SBO:0000247
name: alpha-D-Ribose 1-phosphate
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:57720
is: HMDB01489
has only substance units: false
boundary condition: false
initial amount: NaN
is: C00442

metaR r0818
name: Transport reaction
reactant: MODEL1310110006#
type: Reaction
reversible: false
kinetic law: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:

metaM HC01434 m
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
name: oxalatosuccinate(3-)
is: CHEBI:58931
boundary condition: false

metaM acnam n
is: HMDB00230
constant: false
type: Species
boundary condition: false
is: CHEBI:35418
name: N-acetylneuraminate
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: SBO:0000247

metaR ACACT1rm
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110006#
name: acetyl-CoA C-acetyltransferase, mitochondrial
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction
modifier: MODEL1310110006#

metaR r2131
is described by: ECO:0000000
fast: false
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110006#
is: SBO:0000185
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_883e5294_9769_494e_a6be_f02e4deb21c8
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
name: SCP2
is: C9JC79
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6342

http://identifiers.org/biomodels.db/MODEL1310110006#_8fdb2042_755a_4218_8ea6_f1102d2a9ce1
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:6389
is: P31040
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
name: SDHA

metaR GALt4
reversible: true
kinetic law: MODEL1310110006#
product: MODEL1310110006#
name: galactose transport via sodium symport
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reactant: MODEL1310110006#
fast: false
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110006#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_15cdccef_5cd3_44cf_9657_aa087fdab9b1
boundary condition: true
is encoded by: hsa:57835
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
name: SLC4A5
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_c682abdb_39ce_41d5_a077_bebcc6874266
initial amount: NaN
is: Q8TBF5
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is encoded by: hsa:54965
name: PIGX
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_c8427a9a_453a_4ddc_9673_048718b5e9da
name: PIP5K1A
constant: false
is encoded by: hsa:8394
has only substance units: false
type: Species
boundary condition: true
is: Q99755
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM m2mn l
has only substance units: false
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
is: SBO:0000247
boundary condition: false
type: Species
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
initial concentration: 1.0
initial amount: NaN
is: HMDB06537
constant: false

metaR B3GNT315g
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
modifier: MODEL1310110006#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
product: MODEL1310110006#
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#

metaR PAPtg
reversible: false
type: Reaction
fast: false
name: adenosine 3',5'-bisphosphate Golgi transport
is described by: ECO:0000000
reactant: MODEL1310110006#
is: SBO:0000185
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110006#

metaR r0817
type: Reaction
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185
product: MODEL1310110006#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false

metaR r0962
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
name: Facilitated diffusion
type: Reaction
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110006#_93721e29_cacf_43ed_9d40_1ca07cb696ca
constant: false
name: ACSS2
is: SBO:0000252
is encoded by: hsa:55902
boundary condition: true
type: Species
is: Q5QPH3
initial concentration: NaN
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_2c7e6f5f_e68a_42ea_be54_9d484425df15
is encoded by: hsa:10797
name: MTHFD2
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is: P13995
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR FAOXC205C184x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaR S23Tg
type: Reaction
fast: false
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)
reversible: false
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD
product: MODEL1310110006#
is: SBO:0000176
reactant: MODEL1310110006#
is described by: ECO:0000269
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.99.4

metaR r2133
reactant: MODEL1310110006#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110006#
product: MODEL1310110006#
modifier: MODEL1310110006#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR STRDNCCOAtxc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of stearidonylcoa into peroxisomes.
type: Reaction

metaR DATPtn
name: dATP diffusion in nucleus
product: MODEL1310110006#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110006#_7871bac6_2a94_405b_9300_b9f8c661fbdd
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: AGXT2L1
has only substance units: false
is encoded by: hsa:64850
constant: false
is: Q8TBG4
type: Species

metaR UDPtl
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110006#
fast: false
name: udp intracellular transport
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_fcd050af_6f6f_41bf_a98f_ba2f79fe292c
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:115584
name: SLC5A11
type: Species
initial amount: NaN
is: Q8WWX8
is: SBO:0000252
boundary condition: true

metaM glyclt c
name: glycolate
initial concentration: 1.0
is: HMDB00115
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:29805
type: Species
initial amount: NaN

metaR APAT2rm
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
type: Reaction
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
fast: false
is described by: ECO:0000212
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.6.1.19
product: MODEL1310110006#
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_7434469e_98cc_48f3_b83d_fc15d1efe596
constant: false
name: BAAT
is: SBO:0000252
is encoded by: hsa:570
initial amount: NaN
is: Q14032
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true

metaR TMDPP
fast: false
product: MODEL1310110006#
name: thymidine phosphorylase
notes: GENE_ASSOCIATION: (1890.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.4 Confidence Level: 4 AUTHORS: PMID:7028324,PMID:718961,PMID:9693094 NOTES:
is version of: http://identifiers.org/ec-code/2.4.2.4
type: Reaction
is: SBO:0000176
modifier: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000269

metaR r2132
product: MODEL1310110006#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is: SBO:0000185
reversible: true
type: Reaction
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110006#_79de49bb_8b51_4024_b361_db926a8301e8
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6520
name: SLC3A2
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P08195
constant: false

metaR FAOXC122x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_db3246dd_a9f3_4be1_b2d2_59634448903c
name: CHST1
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:8534
initial amount: NaN
boundary condition: true
is: O43916
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_7ada3222_c921_46a1_9c60_40f1550fc450
is: P13686
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:54
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: ACP5

metaR PIPLCn
is version of: http://identifiers.org/ec-code/3.1.4.11
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110006#
fast: false
name: phosphatidylinositol phospholipase C, nucleus
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_a5829cc7_f0ce_44d1_ad5b_131e08a31143
type: Species
has only substance units: false
name: HK1
initial amount: NaN
is: B3KXY9
initial concentration: NaN
constant: false
is encoded by: hsa:3098
is: SBO:0000252
boundary condition: true

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_311a60cf_37a1_4bf2_9463_c2e6d51f9e6b
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4891
name: SLC11A2
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: B4DK84
type: Species

metaR PI4PLCn
fast: false
reactant: MODEL1310110006#
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#

metaM gsn c
is: C00387
is: HMDB00133
boundary condition: false
has only substance units: false
name: Guanosine
constant: false
initial amount: NaN
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: SBO:0000247
type: Species
is: CHEBI:16750
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_3983e78f_2e6c_4088_84d1_e30d650d4f53
initial concentration: NaN
has only substance units: false
name: SULT1A3
initial amount: NaN
is: P50224
is encoded by: hsa:6818
is: SBO:0000252
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_cae1a8f3_2b78_4ffd_a7e6_bb17a70e959b
is: SBO:0000252
name: B3GNT1
type: Species
is: O43505
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:11041
initial amount: NaN
constant: false

metaM dec24dicoa m
name: 2,4-decadienoylcoa
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
is: HMDB01168
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_acbcf173_abef_43e1_ac65_1e7d3a895b5e
has only substance units: false
constant: false
is encoded by: hsa:38
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P24752
name: ACAT1
type: Species

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaM datp m
is: C00131
boundary condition: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:61404
is: HMDB01532
type: Species
name: dATP

http://identifiers.org/biomodels.db/MODEL1310110006#_63eb9e97_80f4_4b97_ba63_ecdb461a18c5
is: SBO:0000252
name: ALDH6A1
is encoded by: hsa:4329
initial amount: NaN
constant: false
type: Species
is: Q02252
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_2ed459fc_9625_461d_af91_010d0ba4700e
is: P07205
boundary condition: true
type: Species
name: PGK2
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:5232
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_1a3f0733_b9af_48f8_a2cb_0e236f87ad82
is encoded by: hsa:6560
constant: false
is: SBO:0000252
initial amount: NaN
is: F5H066
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
name: SLC12A4

http://identifiers.org/biomodels.db/MODEL1310110006#_0cd74bb2_a729_4f49_89f1_0d996f2bb7cb
name: PDE9A
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5152
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true

metaM imp e
constant: false
boundary condition: false
name: IMP(2-)
initial amount: NaN
type: Species
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
initial concentration: 1.0
is: CHEBI:58053
is: HMDB00175
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_bad2f2e5_0f53_43cb_84db_9ffa1b0bedf1
is: SBO:0000252
type: Species
is encoded by: hsa:3141
initial concentration: NaN
has only substance units: false
is: P50747
name: HLCS
initial amount: NaN
boundary condition: true
constant: false

metaR NACHEX12ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110006#
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110006#
modifier: MODEL1310110006#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
fast: false
product: MODEL1310110006#

metaR G14T17g
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110006#
modifier: MODEL1310110006#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22

metaM q10 e
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
has only substance units: false
initial concentration: 1.0
name: ubiquinone-10
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01072
type: Species
is: CHEBI:46245

metaM apoC c
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
boundary condition: false
is: HMDB11111
notes: FORMULA: XH CHARGE: 0
initial amount: NaN
is: CHEBI:33190
name: Apocarboxlase (no lys residue)
is: SBO:0000247

metaR ECOAH12m
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110006#
reversible: true
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM 3aib c
name: (S)-3-aminoisobutyric acid
is: HMDB02166
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: SBO:0000247
has only substance units: false
type: Species
constant: false
boundary condition: false
is: CHEBI:33094

http://identifiers.org/biomodels.db/MODEL1310110006#_de5cd570_cd64_47cf_a797_e2fc34a87694
constant: false
is encoded by: hsa:5290
initial amount: NaN
boundary condition: true
name: PIK3CA
has only substance units: false
is: P42336
type: Species
initial concentration: NaN
is: SBO:0000252

metaM co2 m
initial amount: NaN
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
name: CO2
is: SBO:0000247
type: Species
is: CHEBI:16526
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM cmp m
initial amount: NaN
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
is: SBO:0000247
name: CMP(2-)
type: Species
is: HMDB00095
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM c6dc x
is: C14143
is: HMDB04047
type: Species
notes: FORMULA: C13H22NO6 CHARGE: -1
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
name: adipoyl carnitine

metaM rbt c
type: Species
constant: false
is: CHEBI:15963
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: D-ribitol
is: HMDB00508
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
boundary condition: false

metaM datp n
is: C00131
constant: false
initial concentration: 1.0
is: CHEBI:61404
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
initial amount: NaN
is: SBO:0000247
name: dATP
has only substance units: false
boundary condition: false
type: Species

metaR S6T15g
kinetic law: MODEL1310110006#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.17
is version of: http://identifiers.org/ec-code/2.8.2.21
modifier: MODEL1310110006#
is: SBO:0000176
type: Reaction
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110006#

metaR PSDm hs
product: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.65
kinetic law: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
is: SBO:0000176
reversible: false
name: Phosphatidylserine decarboxylase
is described by: ECO:0000269

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaM hexdiac r
is: HMDB00672
notes: FORMULA: C16H28O4 CHARGE: -2
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: C08260
name: hexadecanediocacid
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_16b2b786_6e87_42ca_a357_b49573e9b5e0
type: Species
is: SBO:0000252
has only substance units: false
name: MTMR3
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:8897
initial amount: NaN

metaR NACHEX9ly
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110006#
product: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110006#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110006#_0cc5a97a_3d58_48dc_ada6_a6007cc27e07
boundary condition: true
is encoded by: hsa:4882
initial concentration: NaN
is: P20594
type: Species
has only substance units: false
name: NPR2
constant: false
is: SBO:0000252
initial amount: NaN

metaM o2s e
is: HMDB02168
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
constant: false
is: CHEBI:18421
name: superoxide
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM n2m2mn l
boundary condition: false
is: HMDB00742
initial concentration: 1.0
notes: FORMULA: C42H71N3O31 CHARGE: 0
constant: false
type: Species
is: SBO:0000247
is: CHEBI:17588
initial amount: NaN
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_52247f2d_ed3e_4f94_9926_4115f513e17e
constant: false
boundary condition: true
is: Q6P1K9
name: PANK2
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:80025
initial amount: NaN

metaR C4STMO2r
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.14.13.72
product: MODEL1310110006#
reversible: false
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
name: C-4 methyl sterol oxidase
fast: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction

metaM dcdp m
type: Species
is: HMDB01245
is: CHEBI:58593
has only substance units: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
boundary condition: false
initial amount: NaN
name: dCDP(3-)
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM cmp n
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
boundary condition: false
is: CHEBI:60377
is: SBO:0000247
type: Species
is: HMDB00095
constant: false
has only substance units: false
initial amount: NaN
name: CMP(2-)

http://identifiers.org/biomodels.db/MODEL1310110006#_7159eeb8_a7c4_44be_8dd0_4e496c12fc01
is: P27815
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: PDE4A
boundary condition: true
is encoded by: hsa:5141

metaM imp c
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00175
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:58053
name: IMP
boundary condition: false
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: C00130

metaR DCTPtn
fast: false
product: MODEL1310110006#
is: SBO:0000185
reactant: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
name: dCTP diffusion in nucleus
reversible: true
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR FACOAL241
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
name: fatty-acid--CoA ligase
product: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reversible: true
fast: false

metaR r2137
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
product: MODEL1310110006#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reactant: MODEL1310110006#
fast: false
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#

metaR UMPK4n
reactant: MODEL1310110006#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (GTP),nuclear
kinetic law: MODEL1310110006#
reversible: true
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
is: SBO:0000176

metaR TMDPK
fast: false
is version of: http://identifiers.org/ec-code/2.7.6.2
is described by: ECO:0000269
type: Reaction
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110006#
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
is: SBO:0000176
reversible: false
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_2af5da65_533a_40c9_ae61_1370ce937438
is: Q9NYR8
is encoded by: hsa:50700
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: RDH8
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_8605ab03_bf14_4155_af19_04281853624c
is: Q99714
type: Species
boundary condition: true
is: SBO:0000252
name: HSD17B10
initial concentration: NaN
is encoded by: hsa:3028
constant: false
initial amount: NaN
has only substance units: false

metaM q10 c
is: CHEBI:46245
has only substance units: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
name: ubiquinone-10
is: HMDB01072
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

metaM 3hdeccoa c
constant: false
name: 3-hydroxyhexadecenoylcoa
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
is: HMDB02014

metaM dcdp n
boundary condition: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
has only substance units: false
type: Species
is: HMDB01245
is: CHEBI:58593
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: dCDP(3-)

metaR FACOAL240
reactant: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
fast: false
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reversible: true
is described by: ECO:0000269
product: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaM HC01609 e
type: Species
initial amount: NaN
is: CHEBI:28766
initial concentration: 1.0
boundary condition: false
name: UroporphyrinogenI
has only substance units: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
is: SBO:0000247
constant: false

metaM cmp g
constant: false
name: CMP(2-)
initial amount: NaN
is: SBO:0000247
is: HMDB00095
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: CHEBI:60377
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_e6d61109_afb4_4035_a694_4c1b64ac744d
has only substance units: false
boundary condition: true
initial concentration: NaN
name: EHHADH
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is: Q9NY65
is encoded by: hsa:1962

metaM uacgam g
is: HMDB00290
is: CHEBI:57705
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
constant: false
has only substance units: false
initial amount: NaN

metaR FAOXC101C102x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

metaM cyst L c
constant: false
type: Species
notes: FORMULA: C7H14N2O4S CHARGE: 0 INCHI: InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00916
is: SBO:0000247
name: L-cystathionine
is: HMDB00099
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:17482
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_81a81814_f33f_4057_b486_c37d858943ca
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is: Q14542
has only substance units: false
name: SLC29A2
is encoded by: hsa:3177
boundary condition: true

metaR DINt
kinetic law: MODEL1310110006#
reversible: true
fast: false
name: deoxyinosine transport via diffusion
reactant: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_fd782451_e344_45a0_871b_7dc630326d8b
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:R33828
constant: false
name: _R33828_1_c
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_9ec95b81_c894_4b28_b15c_5e459dcde9d3
is: SBO:0000252
is encoded by: hsa:BE966236
initial concentration: NaN
initial amount: NaN
type: Species
name: _BE966236_1_m
boundary condition: true
constant: false
has only substance units: false

metaR DHFR
reversible: true
type: Reaction
reactant: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
name: dihydrofolate reductase
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
is described by: ECO:0000254

metaM o2s c
type: Species
name: superoxide
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: HMDB02168
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:18421
initial concentration: 1.0
is: SBO:0000247

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR It
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
reactant: MODEL1310110006#
is described by: ECO:0000269
fast: false
is: SBO:0000185
name: Iodide uniport
modifier: MODEL1310110006#
type: Reaction
reversible: true
product: MODEL1310110006#

metaM c12dc c
type: Species
notes: FORMULA: C19H34NO6 CHARGE: -1
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: dodecanedioyl carnitine
is: HMDB00623
initial concentration: 1.0

metaR FMNAT
is: SBO:0000176
fast: false
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.7.2
reversible: false
product: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
name: FMN adenylyltransferase

metaR r2139
product: MODEL1310110006#
reversible: true
modifier: MODEL1310110006#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110006#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_2dd3f8be_ec9b_4826_8831_bd480dd5d63f
type: Species
is encoded by: hsa:1854
constant: false
name: DUT
is: SBO:0000252
has only substance units: false
is: P33316
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR FOLt2le
product: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
name: folate transport via anion exchange
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction

metaM sgalside hs c
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB03406
has only substance units: false
name: sulfatide galactocerebroside
is: CHEBI:16523
initial concentration: 1.0
initial amount: NaN

metaR S6TASE13ly
product: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
fast: false

metaR GAPD
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
product: MODEL1310110006#
modifier: MODEL1310110006#
name: glyceraldehyde-3-phosphate dehydrogenase
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110006#
reversible: true
type: Reaction
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.2.1.12
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_10d94ee6_6d5d_402e_80dd_081d044d4f93
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: SLC28A2
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:9153
is: O43868
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_8e963046_dd49_4823_9b9b_42b5fd961afb
initial amount: NaN
initial concentration: NaN
constant: false
name: LPGAT1
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is: Q92604
is encoded by: hsa:9926

metaM aps c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58243
constant: false
type: Species
name: 5'-adenylyl sulfate(2-)
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
initial amount: NaN
has only substance units: false
is: HMDB01003

http://identifiers.org/biomodels.db/MODEL1310110006#_1d7e9cea_a110_4063_98ee_2cf450863912
is: P31213
type: Species
is: SBO:0000252
constant: false
name: SRD5A2
has only substance units: false
boundary condition: true
is encoded by: hsa:6716
initial amount: NaN
initial concentration: NaN

metaM CE5116 x
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,19-20,28-30,34-36,40,51-52H,4-7,10,13,16-18,21-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,20-19+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE5116
name: trans-3-cis-8,11,14-eicosatetraenoyl-CoA
constant: false
is: CHEBI:57923
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species

metaR DAGt
name: diacylglycerol transport
is described by: ECO:0000269
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110006#
type: Reaction

metaR FACOAL180i
modifier: MODEL1310110006#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
name: C180 fatty acid activation
product: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
type: Reaction

metaM hepcoa m
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C28H44N7O17P3S CHARGE: -4
type: Species
initial concentration: 1.0
initial amount: NaN
name: heptanoylcoa
is: SBO:0000247
is: HMDB12969

http://identifiers.org/biomodels.db/MODEL1310110006#_f5238c48_ba84_4f46_b496_0cb4bc53e261
initial concentration: NaN
is encoded by: hsa:3163
type: Species
is: SBO:0000252
name: HMOX2
has only substance units: false
is: P30519
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_b15e4c1f_fde6_4863_8bdf_073894850686
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:BC005314
boundary condition: true
constant: false
name: _BC005314_1_x
is: SBO:0000252

metaM e4hglu m
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
has only substance units: false
constant: false
name: erythro-4-hydroxy-L-glutamate(1-)
initial concentration: 1.0
is: CHEBI:6331
initial amount: NaN
is: HMDB02273

metaM CE4872 c
initial concentration: 1.0
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:15748
constant: false
boundary condition: false
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
is: HMDB00127
initial amount: NaN

metaR GUAPRT
is: SBO:0000176
modifier: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
name: guanine phosphoribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
fast: false
is described by: ECO:0000269
product: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_7ccd7a26_f710_43e6_9dc9_a654540d3526
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
boundary condition: true
has part: B2RAU6
is encoded by: hsa:5279
initial amount: NaN
is encoded by: hsa:9091
initial concentration: NaN
constant: false
is encoded by: hsa:51227
is encoded by: hsa:5277
has only substance units: false
is: SBO:0000297
has part: P57054
type: Species

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaR FAOXC185C164m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

metaR NDPK2
is: SBO:0000176
reactant: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
reversible: true
name: nucleoside-diphosphate kinase (ATP:UDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110006#
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_d3938f8c_fcf7_427f_882c_dc4cdb6e024e
type: Species
initial amount: NaN
is: P56181
initial concentration: NaN
is encoded by: hsa:4731
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
name: NDUFV3

metaR FAOXC163GC142m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaM 4nphsf c
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:35422
constant: false
initial concentration: 1.0
is: HMDB06492
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
name: 4-Nitrophenyl sulfate
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_14edc4ca_668a_4f0d_8eec_ef01091316d4
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: ALDOA
constant: false
initial amount: NaN
is encoded by: hsa:226

metaM gcald c
initial concentration: 1.0
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
name: glycolaldehyde
is: SBO:0000247
initial amount: NaN
is: CHEBI:17071
has only substance units: false
boundary condition: false
constant: false
type: Species
is: HMDB03344

metaR r0403
is described by: ECO:0000000
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
is version of: http://identifiers.org/ec-code/1.2.4.4
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000176
reversible: true
product: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110006#

metaM c16dc e
is: HMDB00712
initial amount: NaN
has only substance units: false
boundary condition: false
name: Hexadecanedioic acid mono-L-carnitine ester
notes: FORMULA: C23H42NO6 CHARGE: -1
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR LEUKTRE4t
product: MODEL1310110006#
reactant: MODEL1310110006#
reversible: true
is: SBO:0000185
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: leukotriene E4 transport
kinetic law: MODEL1310110006#

metaM ksi deg10 l
constant: false
is: CHEBI:57455
name: keratan sulfate I, degradation product 10
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB01354
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_16f357bd_daaf_4457_836b_46c173c85e83
is: SBO:0000252
is encoded by: hsa:386757
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
name: SLC6A10P
boundary condition: true
constant: false

metaM tmndnc c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/446284
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: HMDB01999
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
name: timnodonic acid C20:5, n-3
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_f60087c4_dc48_48b9_82f0_20b70a7364e4
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: CLYBL
type: Species
is: SBO:0000252
is encoded by: hsa:171425

metaR PYDXPP
notes: GENE_ASSOCIATION: (57026.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:14522954,PMID:6380540 NOTES:
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000176
modifier: MODEL1310110006#
reactant: MODEL1310110006#
name: Pyridoxal 5-phosphate phosphatase
product: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.3
is described by: ECO:0000304
reversible: false

metaR NDPK1
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
fast: false
product: MODEL1310110006#
is described by: ECO:0000134
name: nucleoside-diphosphate kinase (ATP:GDP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110006#_db8e3978_8daa_4e07_8da8_593329f8de60
constant: false
is: SBO:0000252
has only substance units: false
name: PDE7B
is: Q9NP56
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:27115

metaR C50CPT1
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

metaR SERGLNexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110006#
fast: false
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000304
product: MODEL1310110006#
name: L-Serine/Glutamine reversible exchange
reversible: true
modifier: MODEL1310110006#

metaR PI45P5Pn
fast: false
reactant: MODEL1310110006#
reversible: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110006#
type: Reaction
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear

metaR r0074
reversible: true
is: SBO:0000176
reactant: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
type: Reaction

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR PAFS
is: SBO:0000176
kinetic law: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: NOTES:NJ
name: alkyl glycerol phosphocholine acetyl transferase
reversible: false

metaR P5CRxm
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:PRO1x is irreversible in the other direction
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
name: pyrroline-5-carboxylate reductase (m)
reactant: MODEL1310110006#
is described by: ECO:0000304
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: false
type: Reaction
is: SBO:0000176

metaM 34dhmald c
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB06242
has only substance units: false
is: http://identifiers.org/pubchem.compound/7903
initial amount: NaN
name: 3,4-Dihydroxymandelaldehyde
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: C05577

metaM sgalside hs g
is: HMDB00061
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
name: sulfatide galactocerebroside
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: CHEBI:58343
initial concentration: 1.0

metaM uacgam c
initial concentration: 1.0
is: CHEBI:57705
boundary condition: false
constant: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: HMDB00290
is: SBO:0000247
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_08fdc521_b25c_4213_a804_b031b37de0ca
initial amount: NaN
boundary condition: true
is: O00767
constant: false
is: SBO:0000252
name: SCD
initial concentration: NaN
type: Species
is encoded by: hsa:6319
has only substance units: false

metaM ksi deg19 l
notes: FORMULA: C146H236N10O124S6 CHARGE: -6
constant: false
is: HMDB01354
initial concentration: 1.0
is: SBO:0000247
type: Species
name: keratan sulfate I, degradation product 19
is: CHEBI:57455
initial amount: NaN
has only substance units: false
boundary condition: false

metaM nmn c
has only substance units: false
is: HMDB00229
name: NMN
is: CHEBI:14649
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: C00455
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN

metaM sphs1p e
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
name: sphingosine 1-phosphate(1-)
initial concentration: 1.0
is: CHEBI:60119
is: HMDB00277

metaR ADSS
kinetic law: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/6.3.4.4
modifier: MODEL1310110006#
type: Reaction
name: adenylosuccinate synthase
product: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000176
reversible: false

metaR EX c4crn
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaM 4nphsf e
is: SBO:0000247
is: HMDB06492
is: CHEBI:35422
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C6H4NO6S CHARGE: -1 INCHI: InChI=1S/C6H5NO6S/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H,10,11,12)
name: 4-Nitrophenyl sulfate

http://identifiers.org/biomodels.db/MODEL1310110006#_abdb883c_fe97_4f64_bbac_bd14bcafb339
has only substance units: false
initial concentration: NaN
name: AGPAT5
boundary condition: true
initial amount: NaN
is: Q9NUQ2
is encoded by: hsa:55326
constant: false
is: SBO:0000252
type: Species

metaM datp c
name: dATP
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:61404
is: C00131
is: HMDB01532
type: Species
is: SBO:0000247

metaR GLCter
product: MODEL1310110006#
name: glucose transport, endoplasmic reticulum
reactant: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reversible: true
fast: false

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR ARSA
reactant: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
product: MODEL1310110006#
name: Arylsulfatase A
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.8
kinetic law: MODEL1310110006#
fast: false
reversible: false

metaR CDIPTr
product: MODEL1310110006#
name: phosphatidylinositol synthase (Homo sapiens)
is: SBO:0000176
reversible: true
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
is version of: http://identifiers.org/ec-code/2.7.8.11
type: Reaction
kinetic law: MODEL1310110006#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110006#

metaR TREHe
is described by: ECO:0000269
reactant: MODEL1310110006#
is: SBO:0000176
name: alpha,alpha-trehalase
kinetic law: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.28

metaR ACNAMtn
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110006#
reactant: MODEL1310110006#
name: N-acetylneuraminate nuclear import
kinetic law: MODEL1310110006#
is: SBO:0000185
reversible: false

metaR r1435
product: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Transport reaction
reversible: false
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:

metaM Ser Thr g
name: protein-linked serine or threonine residue (O-glycosylation site)
constant: false
is: SBO:0000247
is: CHEBI:58336
boundary condition: false
type: Species
is: HMDB00645
notes: FORMULA: XH CHARGE: 0
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM cholcoa c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: CHEBI:57373
name: choloyl-CoA(4-)
has only substance units: false
type: Species
constant: false
is: HMDB01374
boundary condition: false

metaR HDECEACBP
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_549d299c_42df_496d_afdf_9fe9062d729b
is encoded by: hsa:6319
boundary condition: true
name: SCD
has only substance units: false
is: O00767
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaM sphs1p c
has only substance units: false
is: SBO:0000247
is: HMDB00277
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
constant: false
initial concentration: 1.0
name: sphingosine 1-phosphate(1-)
is: CHEBI:60119

http://identifiers.org/biomodels.db/MODEL1310110006#_303e03e5_8af0_4af0_b6f4_4b35f8c01011
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q9Y672
initial concentration: NaN
is encoded by: hsa:29929
boundary condition: true
name: ALG6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_a2231c8b_7511_41f1_b262_321d5a82608d
initial amount: NaN
constant: false
is encoded by: hsa:6817
has only substance units: false
type: Species
initial concentration: NaN
name: SULT1A1
boundary condition: true
is: SBO:0000252

metaR r0603
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.12
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
is described by: ECO:0000000
reactant: MODEL1310110006#
fast: false
type: Reaction
modifier: MODEL1310110006#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_020ae249_6405_44e0_a09c_baa615b01b58
type: Species
is: O43772
is: SBO:0000252
name: SLC25A20
boundary condition: true
is encoded by: hsa:788
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN

metaR MTHFD2
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NAD)
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
kinetic law: MODEL1310110006#
is described by: ECO:0000134
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
product: MODEL1310110006#
modifier: MODEL1310110006#

metaM co2 r
is: SBO:0000247
is: HMDB01967
is: CHEBI:16526
constant: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
name: CO2
is: C00011

metaR ENGASE3ly
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
name: endo-beta-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110006#
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110006#
is described by: ECO:0000000

metaM sgalside hs l
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: SBO:0000247
name: sulfatide galactocerebroside
is: CHEBI:16349
is: HMDB00904
type: Species
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false

metaR r1913
reactant: MODEL1310110006#
reversible: false
modifier: MODEL1310110006#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110006#_174b978f_0521_4c26_bc02_5897f246cbd5
is: E2QC23
is encoded by: hsa:23464
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: GCAT
boundary condition: true

metaM ksii core4 pre8 g
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: CHEBI:58053
is: HMDB00175
has only substance units: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 8
notes: FORMULA: C83H134N7O61SX CHARGE: -2
is: C00130
initial concentration: 1.0

metaR FUMSO4tm
name: Fumarate:sulfate antiport, mitochondrial
kinetic law: MODEL1310110006#
product: MODEL1310110006#
fast: false
modifier: MODEL1310110006#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
reactant: MODEL1310110006#
type: Reaction

metaR NDPK6
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110006#
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
name: Nucleoside-diphosphate kinase (ATP:dUDP)
fast: false
is described by: ECO:0000269
is: SBO:0000176

metaR r0407
product: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.5
type: Reaction
modifier: MODEL1310110006#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
is described by: ECO:0000000
reversible: true

metaR FAOXC12DCx
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaM ksi deg21 l
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
constant: false
initial amount: NaN
is: HMDB00143
boundary condition: false
name: keratan sulfate I, degradation product 21
type: Species
is: CHEBI:12936
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_fc7201a1_31bd_40e8_a367_7b953b23b47c
has only substance units: false
name: SLC25A1
is encoded by: hsa:6576
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: D9HTE9
is: SBO:0000252
constant: false

metaR EX doco13ac
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaM ksi deg32 l
has only substance units: false
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB00143
name: keratan sulfate I, degradation product 32
initial amount: NaN
is: CHEBI:12936
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_3d322cde_4f54_4008_8358_faee5d49a233
constant: false
initial amount: NaN
name: NT5C2
is: P49902
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:22978
boundary condition: true
type: Species

metaR G14T15g
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR FADH2tx
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
type: Reaction
name: FADH2 transporter, peroxisomal
is described by: ECO:0000000
reversible: true
product: MODEL1310110006#
is: SBO:0000185
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#

metaM c4crn e
has only substance units: false
is: HMDB02013
type: Species
is: http://identifiers.org/pubchem.compound/213144
initial concentration: 1.0
name: butyryl carnitine
is: C02862
initial amount: NaN
boundary condition: false
notes: FORMULA: C11H21NO4 CHARGE: 0
is: SBO:0000247
constant: false

metaR FUT911g
fast: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.152
reversible: false
is: SBO:0000176
is described by: ECO:0000269
name: Alpha-(1,3)-fucosyltransferase
product: MODEL1310110006#
type: Reaction

metaR r0408
modifier: MODEL1310110006#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.5
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
fast: false
type: Reaction
reactant: MODEL1310110006#
is described by: ECO:0000000
reversible: true
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
kinetic law: MODEL1310110006#

metaR NDPK5
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000269
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Nucleoside-diphosphate kinase (ATP:dGDP)
is: SBO:0000176
fast: false

metaM HC00718 c
name: N-methylethanolaminium phosphate(1-)
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:57781

metaR DPMVDc
name: diphosphomevalonate decarboxylase, cytosol
is: SBO:0000176
reversible: false
type: Reaction
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.1.1.33
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
fast: false
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_fd86297a_7b59_48c3_b6b0_1a77f9d3194c
has only substance units: false
initial amount: NaN
is: Q15147
is encoded by: hsa:5332
type: Species
initial concentration: NaN
name: PLCB4
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_e53f41c5_b970_432f_9bea_d8dfe3aff188
is: B2R6S5
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: CMPK1
is encoded by: hsa:51727
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_0dded8f7_325e_4f10_8e5b_8623549128a6
boundary condition: true
is encoded by: hsa:8395
initial concentration: NaN
type: Species
name: PIP5K1B
is: SBO:0000252
has only substance units: false
is: O14986
initial amount: NaN
constant: false

metaM h x
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: http://identifiers.org/pubchem.compound/3380
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:24636
constant: false
is: C00080
boundary condition: false
name: proton

metaM mem2emgacpail prot hs r
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00224
name: ({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol-Protein (M4B)
constant: false
notes: FORMULA: C59H110N3O40P3FULLRCO2FULLR2CO2X CHARGE: 0
is: CHEBI:58190

metaM 13 cis retn r
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: HMDB06219
has only substance units: false
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/7847414
is: D00348
boundary condition: false
name: 13-cis-retinoate
initial amount: NaN
initial concentration: 1.0
type: Species

metaR FBA2
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000304
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: MODEL1310110006#
product: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
fast: false
reversible: true

metaR CSNAT2x
modifier: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
is: SBO:0000176
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110006#
fast: false
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.137
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110006#_5a725e3d_01db_48e7_93cb_92f4c1f7668b
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:85365
initial concentration: NaN
has only substance units: false
is: Q9H553
boundary condition: true
name: ALG2
initial amount: NaN

metaR MG2er
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110006#
fast: false
is: SBO:0000176
reactant: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD

metaR NDPK4
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110006#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110006#
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:dTDP)

metaR GLNtN1
reactant: MODEL1310110006#
is described by: ECO:0000269
name: Glutamine transport (Na, H coupled)
kinetic law: MODEL1310110006#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110006#
reversible: true
fast: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

metaR PACCOAL
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
name: phenylacetate-CoA ligase
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
product: MODEL1310110006#
type: Reaction

metaM gly m
initial amount: NaN
is: C00037
name: Glycine
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial concentration: 1.0
boundary condition: false
is: CHEBI:15428
type: Species
is: HMDB00123
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_a50f61a1_acea_4651_811c_c30aae443e26
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: SLC24A4
type: Species
is encoded by: hsa:123041
has only substance units: false
is: Q8NFF2
initial amount: NaN

metaR r0409
modifier: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000176
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.10
type: Reaction
name: UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275 NOTES:
kinetic law: MODEL1310110006#

metaR PHYCBOXL
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
modifier: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
product: MODEL1310110006#
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/4.1.1.28
name: L-Phenylalanine carboxy-lyase
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110006#
type: Reaction

metaM c16dc c
notes: FORMULA: C23H42NO6 CHARGE: -1
is: HMDB00712
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
constant: false
name: Hexadecanedioic acid mono-L-carnitine ester

metaR B3GALT5g
reversible: false
name: Beta-1,3-galactosyltransferase 5
product: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176
reactant: MODEL1310110006#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_72aed095_3387_42b4_adc6_a9bc4e77cb35
name: SLC23A2
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q9UGH3
type: Species
is encoded by: hsa:9962
initial concentration: NaN

metaR r1569
product: MODEL1310110006#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110006#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_993dff68_d6e9_4b7d_8c19_86ede7c91540
is: Q8IYH3
is encoded by: hsa:3036
constant: false
boundary condition: true
name: HAS1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

metaR FACOAL224
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110006#
product: MODEL1310110006#
fast: false
type: Reaction
modifier: MODEL1310110006#
name: fatty-acid--CoA ligase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110006#

metaR DESAT22 2p
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110006#
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
fast: false
reversible: false
type: Reaction
product: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#

metaR MI1P Dtn
is described by: ECO:0000000
type: Reaction
product: MODEL1310110006#
name: inositol 1-phosphate nuclear transport (diffusion)
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaR CORE2GTg
type: Reaction
reactant: MODEL1310110006#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.102
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: false
is: SBO:0000176
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus

metaR FAOXC226C225m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaR S6T9g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110006#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
product: MODEL1310110006#
reversible: false
reactant: MODEL1310110006#

metaR NDPK3
reactant: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:CDP)
kinetic law: MODEL1310110006#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176

metaM decdicoa c
boundary condition: false
constant: false
type: Species
is: SBO:0000247
name: decadienoylcoa
is: HMDB01168
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM c4crn c
boundary condition: false
notes: FORMULA: C11H21NO4 CHARGE: 0
is: HMDB02013
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/213144
is: C02862
is: SBO:0000247
name: butyryl carnitine
initial amount: NaN
constant: false
type: Species

metaM sarcs m
name: Sarcosine
has only substance units: false
is: CHEBI:15611
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C00213
is: HMDB00271
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_9b256da8_2880_4059_9156_020d680a3d2d
boundary condition: true
is: Q16635
initial amount: NaN
is encoded by: hsa:6901
is: SBO:0000252
name: TAZ
initial concentration: NaN
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_d330ff68_58b5_4465_8f3c_26eb249df012
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:10587
name: TXNRD2
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaM 3aib e
is: HMDB02166
name: (S)-3-aminoisobutyric acid
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: CHEBI:33094
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_21ca6d04_50e9_4657_9cb6_4c5a3d44e9b9
type: Species
initial amount: NaN
is: P15531
boundary condition: true
name: NME1
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:4830
has only substance units: false

metaR FBA4
is: SBO:0000176
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110006#
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.13
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
product: MODEL1310110006#

metaM ctdecdcoa m
type: Species
is: HMDB00792
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
name: cis2trans4decadienoylcoa
is: C08277
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_6461f7eb_85a3_4e22_b9fa_7e034ef52012
is encoded by: hsa:6579
name: SLCO1A2
boundary condition: true
is: P46721
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_4a24f147_f5e8_4d37_955f_c50a27338191
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:8875
is: SBO:0000297
name: VNN3:VNN2:VNN1
is encoded by: hsa:8876
has only substance units: false
is encoded by: hsa:55350
has part: A8K7W0
has part: O95497
boundary condition: true

metaR r1568
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaR MMTSADm
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
product: MODEL1310110006#
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_b6a64622_28e2_4339_ab1f_2a99c1580a21
boundary condition: true
name: NT5C1B
is encoded by: hsa:93034
is: Q96P26
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN

metaR GLYKm
is described by: ECO:0000254
type: Reaction
fast: false
name: glycerol kinase
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.1.30
reversible: false
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (2710.2) or (2712.1) or (2710.1) or (2713.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.30 Confidence Level: 2 AUTHORS: PMID:7987308 NOTES:TV
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_8aee9847_5c47_4e8f_bc61_c847f9c44339
initial concentration: NaN
is encoded by: hsa:5860
initial amount: NaN
name: QDPR
boundary condition: true
constant: false
type: Species
is: P09417
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_38731693_7982_448f_a459_867953cc4b40
is: P14618
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:5315
name: PKM2
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species

metaM Ser Thr l
initial amount: NaN
is: HMDB00224
initial concentration: 1.0
constant: false
name: protein-linked serine or threonine residue (O-glycosylation site)
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: XH CHARGE: 0
is: CHEBI:58190
is: SBO:0000247

metaM 3hdeccoa m
is: HMDB02288
is: SBO:0000247
type: Species
has only substance units: false
name: 3-hydroxyhexadecenoylcoa
notes: FORMULA: C37H60N7O18P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false

metaR r1567
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR FACOAL226
product: MODEL1310110006#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
name: fatty-acid--CoA ligase
fast: false
modifier: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_34b3917e_609f_40de_b41a_ac2997e17f7b
initial concentration: NaN
has only substance units: false
name: ACAT1
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:38
is: P24752

http://identifiers.org/biomodels.db/MODEL1310110006#_11e9874c_81e5_437f_b8b9_610857687458
is encoded by: hsa:1743
initial concentration: NaN
boundary condition: true
name: DLST
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is: P36957
initial amount: NaN

metaM 3octdectecoa m
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
constant: false
name: 3,6,9,12-octadecatetraenoylcoa
is: http://identifiers.org/pubchem.compound/5280355
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false

metaR CYANt
type: Reaction
fast: false
reactant: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
is described by: ECO:0000000
reversible: true
name: Cyanide transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_350600c5_fdcf_4ef4_9e67_10396b37b94f
constant: false
is encoded by: hsa:8706
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: B3GALNT1
is: O75752
boundary condition: true

metaR OLEICFATPtc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of octadecenoate by the enterocytes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
constant: false
is: HMDB00174
type: Species
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
is: CHEBI:18287
initial amount: NaN
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR SIAASE3ly
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
name: sialidase, lysosomal
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR B3GNT313g
kinetic law: MODEL1310110006#
is described by: ECO:0000254
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
type: Reaction
reactant: MODEL1310110006#
fast: false
is: SBO:0000176
product: MODEL1310110006#
reversible: false

metaR ASNtN1
modifier: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
name: Asparagine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110006#
fast: false
is: SBO:0000185
product: MODEL1310110006#

metaR FAOXC226C225x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

metaM 13 cis retn n
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB06219
type: Species
is: D00348
initial concentration: 1.0
initial amount: NaN
name: 13-cis-retinoate
constant: false
is: http://identifiers.org/pubchem.compound/7847414

metaR r1566
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110006#
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110006#
product: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR ADPtx
product: MODEL1310110006#
name: ADP transporter, peroxisomal
is: SBO:0000185
fast: false
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
reactant: MODEL1310110006#
type: Reaction
reversible: true
is described by: ECO:0000000

metaR DOPAtu
name: Dopamine uniport
fast: false
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000269
product: MODEL1310110006#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
reactant: MODEL1310110006#

metaM hcys L c
initial amount: NaN
constant: false
is: CHEBI:17588
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00742
name: L-homocysteine

metaM ptdca c
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00826
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
initial concentration: 1.0
has only substance units: false
name: pentadecanoate
is: http://identifiers.org/pubchem.compound/22169126
constant: false
boundary condition: false

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaR RE3270C
product: MODEL1310110006#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110006#
name: RE3270
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
reactant: MODEL1310110006#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_d683fe2b_9f4e_46eb_b562_e67c3a1998cb
is: O14732
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3613
type: Species
name: IMPA2
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_38c5dc8d_3f90_43c5_926b_654af9b7ddb8
is encoded by: hsa:10993
boundary condition: true
type: Species
is: P20132
name: SDS
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false

metaR 3AIBtm
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: false
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.6.1.19
name: 3-amino-isobutyrate transport, mitochondrial

metaM glyc R c
has only substance units: false
is: CHEBI:16659
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: HMDB00139
constant: false
initial concentration: 1.0
name: D-glycerate
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species

metaM adp m
constant: false
is: http://identifiers.org/pubchem.compound/3310
initial concentration: 1.0
is: HMDB01341
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: ADP
is: C00008
type: Species
is: CHEBI:456216

metaR r1565
reactant: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR GUACYC
kinetic law: MODEL1310110006#
name: guanylate cyclase
product: MODEL1310110006#
reactant: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.6.1.2
reversible: false
fast: false

metaR ADSK
reversible: false
name: adenylyl-sulfate kinase
product: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
modifier: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.1.25
is: SBO:0000176

metaM ksi deg14 l
initial concentration: 1.0
has only substance units: false
constant: false
name: keratan sulfate I, degradation product 14
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
type: Species
is: CHEBI:12936
initial amount: NaN
is: HMDB00143
boundary condition: false
is: SBO:0000247

metaR S6TASE9ly
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
reversible: true
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: N-acetylgalactosamine-6-sulfatase, lysosomal
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110006#

metaR GALASE14ly
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110006#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110006#
reactant: MODEL1310110006#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110006#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_e
is: SBO:0000247
constant: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
type: Species
is: CHEBI:15824
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00660
is: C00095
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_91baf426_8a3c_401b_b7e9_04ec8ddb2dba
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10840
has only substance units: false
is: O75891
initial amount: NaN
constant: false
name: ALDH1L1
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_8a142fb9_b9f8_48a8_b5aa_8e34c71ff3c2
is encoded by: hsa:9517
is encoded by: hsa:10558
initial concentration: NaN
has only substance units: false
constant: false
has part: O15270
boundary condition: true
has part: O15269
type: Species
is: SBO:0000297
name: SPTLC1:SPTLC2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_8390628c_5a32_41a8_a5fc_c9723e127007
is: SBO:0000252
is encoded by: hsa:2582
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: GALE
is: Q38G75

metaR DM 13 cis retn n
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 13-cis-retinoate demand
type: Reaction

metaR r1564
reactant: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110006#

metaM adp n
initial concentration: 1.0
name: ADP(3-)
type: Species
has only substance units: false
is: HMDB01341
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: SBO:0000247
is: CHEBI:456216

http://identifiers.org/biomodels.db/MODEL1310110006#_532e2294_aa10_46ed_9f7d_c6fc78ca2b35
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:AA977580
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
name: _AA977580_1_c

metaR NACHEX27ly
kinetic law: MODEL1310110006#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
product: MODEL1310110006#
fast: false
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
type: Reaction

metaM gly x
name: glycine
has only substance units: false
constant: false
is: CHEBI:15428
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial concentration: 1.0
is: HMDB00123
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_0b53960f_34fe_4cf8_ab03_0adec7070907
type: Species
initial concentration: NaN
is encoded by: hsa:111
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ADCY5
is: O95622
has only substance units: false

metaR r1434
is described by: ECO:0000000
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
name: Transport reaction
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
product: MODEL1310110006#

metaR PMANM
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.4.2.8
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
fast: false
is: SBO:0000176
type: Reaction
name: phosphomannomutase
modifier: MODEL1310110006#
product: MODEL1310110006#
reversible: true
is version of: http://identifiers.org/ec-code/5.4.2.2
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

metaR r1563
reactant: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110006#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110006#

metaR r0756
notes: GENE_ASSOCIATION: (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is: SBO:0000176
reversible: true
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.3.1
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
kinetic law: MODEL1310110006#
is described by: ECO:0000000
modifier: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_1a577846_a99b_47a5_bbb4_53c87f1a6810
is encoded by: hsa:84264
constant: false
name: HAGHL
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q6PII5

metaM m7mpdol L r
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
has only substance units: false
is: SBO:0000247
is: CHEBI:37636
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false

metaR C6DCCACT
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_0cd9d474_5b79_44f6_a0d2_4500d40ab424
type: Species
initial concentration: NaN
constant: false
is: Q16762
has only substance units: false
is encoded by: hsa:7263
is: SBO:0000252
boundary condition: true
name: TST
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_4fc4db8c_0244_4b60_a883_a9c1da5b486b
has only substance units: false
constant: false
is encoded by: hsa:56894
name: AGPAT3
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR URIt4
product: MODEL1310110006#
reactant: MODEL1310110006#
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110006#
name: uridine transport in via sodium symport
notes: GENE_ASSOCIATION: (9154.2) or (9154.1) or (64078.1) or (9153.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB

metaR P4508B11r
is described by: ECO:0000269
reactant: MODEL1310110006#
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110006#
name: sterol 12-alpha-hydroxylase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.95
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_f688593e_bb5a_4a4c_ab77_8758d9c5c02c
is encoded by: hsa:8525
name: DGKZ
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: B7Z6M3
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_c
initial amount: NaN
has only substance units: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
type: Species
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
is: SBO:0000247
is: HMDB00174
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:18287

http://identifiers.org/biomodels.db/MODEL1310110006#_80194cbf_5625_4498_badd_dfcaf1b781a6
has only substance units: false
name: AQP8
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is: O94778
is encoded by: hsa:343
initial concentration: NaN
boundary condition: true

metaM dec24dicoa x
initial amount: NaN
has only substance units: false
type: Species
is: HMDB01168
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 2,4-decadienoylcoa
boundary condition: false
is: SBO:0000247
constant: false

metaR r1433
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
product: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110006#
fast: false
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
reversible: false
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_2d6bfbe7_f3b2_453c_a5d2_91626c4331dd
is: Q86VV3
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
name: ENTPD1
is encoded by: hsa:953
constant: false
initial concentration: NaN

metaR r1562
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110006#

metaM CE2420 m
is: HMDB11123
has only substance units: false
boundary condition: false
is: CHEBI:28387
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_c398172f_ce39_4758_b37c_782fd5417e68
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q9Y2D0
type: Species
name: CA5B
is: SBO:0000252
is encoded by: hsa:11238
constant: false

metaM sarcs c
is: CHEBI:3513
is: HMDB00271
name: Sarcosine
type: Species
has only substance units: false
is: C00213
is: SBO:0000247
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR CLPNDCOAtx
name: fatty acid intracellular transport
is: SBO:0000185
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
kinetic law: MODEL1310110006#
type: Reaction
fast: false
reactant: MODEL1310110006#
is described by: ECO:0000000

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_531fa220_208d_43dc_91ce_71bd814cc14b
boundary condition: true
type: Species
is encoded by: hsa:384
initial concentration: NaN
name: ARG2
initial amount: NaN
is: P78540
has only substance units: false
constant: false
is: SBO:0000252

metaR r0757
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is version of: http://identifiers.org/ec-code/3.5.4.16
is: SBO:0000176
reactant: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
reversible: true
type: Reaction
kinetic law: MODEL1310110006#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:

metaM ksii core4 pre7 g
is: C00130
initial concentration: 1.0
is: HMDB00175
initial amount: NaN
constant: false
is: CHEBI:58053
type: Species
name: keratan sulfate II biosynthesis, precursor 7
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C75H121N6O56SX CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110006#_025a4064_c551_4dc1_b267_608e22e9171f
type: Species
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:NM 013421
initial concentration: NaN
name: _NM_013421_1_e
initial amount: NaN
is: SBO:0000252

metaR LEULEULAPc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaR SUBERICACT
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

metaR RE1527M
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
reactant: MODEL1310110006#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
product: MODEL1310110006#
is described by: ECO:0000000
name: RE1527
type: Reaction
modifier: MODEL1310110006#

metaR GHMT2rm
type: Reaction
name: glycine hydroxymethyltransferase, reversible, mitochondrial
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.1.2.1
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110006#

metaM 3aib m
initial concentration: 1.0
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
has only substance units: false
name: (S)-3-aminoisobutyric acid
is: CHEBI:33094
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB02166

http://identifiers.org/biomodels.db/MODEL1310110006#_b1c00da8_0686_4e63_bb71_fb4e58fd4c98
has only substance units: false
is encoded by: hsa:23396
is: SBO:0000252
initial amount: NaN
name: PIP5K1C
constant: false
initial concentration: NaN
type: Species
is: O60331
boundary condition: true

metaR PDE4
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.4.17
is: SBO:0000176
fast: false
reversible: false
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
name: 3',5'-cyclic-nucleotide phosphodiesterase
reactant: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.4.35

http://identifiers.org/biomodels.db/MODEL1310110006#_9d67664b_5c16_4328_86e9_323c3449d6a1
is: Q9GZV3
boundary condition: true
is: SBO:0000252
name: SLC5A7
has only substance units: false
is encoded by: hsa:60482
initial concentration: NaN
initial amount: NaN
constant: false
type: Species

metaR r1561
fast: false
is: SBO:0000185
reactant: MODEL1310110006#
product: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110006#
reversible: true
is described by: ECO:0000000
type: Reaction

metaR NACHEX11ly
reactant: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
is described by: ECO:0000000
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction

metaM gpi sig r
initial amount: NaN
constant: false
type: Species
boundary condition: false
notes: FORMULA: Y CHARGE: 0
is: SBO:0000247
is: HMDB00224
initial concentration: 1.0
has only substance units: false
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)
is: CHEBI:58190

metaM orot5p c
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
is: CHEBI:57538
has only substance units: false
is: SBO:0000247
is: C01103
initial amount: NaN
type: Species
name: Orotidine 5'-phosphate
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00218

metaM co2 x
is: CHEBI:16526
type: Species
initial concentration: 1.0
name: carbon dioxide
boundary condition: false
is: HMDB01967
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 INCHI: InChI=1S/CO2/c2-1-3 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
constant: false
initial amount: NaN
is: SBO:0000247

metaM CE5236 n
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
name: O2'-4a-cyclic-tetrahydrobiopterin
is: HMDB03952
constant: false
has only substance units: false
is: CHEBI:28002
type: Species

metaR EX c4dc
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for succinyl carnitine
type: Reaction

metaM etfrd m
is: SBO:0000247
name: Electron transfer flavoprotein reduced
type: Species
is: CHEBI:30825
notes: FORMULA: RH2 CHARGE: 0
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00573
boundary condition: false

metaR ACETONEt2m
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
name: acetone mitochondrial transport via proton symport
type: Reaction
modifier: MODEL1310110006#

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM sarcs e
name: sarcosine
is: HMDB00271
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: CHEBI:15611

http://identifiers.org/biomodels.db/MODEL1310110006#_17b7d0d4_88dd_44e9_ba6e_3d0e283a000f
constant: false
initial amount: NaN
name: _M68895_1_c
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:M68895
boundary condition: true
initial concentration: NaN

metaR r1560
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_d046d1e8_1232_432d_9894_5d8d8ed4b3a1
type: Species
boundary condition: true
is encoded by: hsa:5315
has only substance units: false
is: SBO:0000252
name: PKM2
initial concentration: NaN
initial amount: NaN
constant: false
is: P14618

metaM tmndnc e
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01999
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
constant: false
initial concentration: 1.0
initial amount: NaN
name: timnodonic acid C20:5, n-3
boundary condition: false
is: http://identifiers.org/pubchem.compound/446284

http://identifiers.org/biomodels.db/MODEL1310110006#_b236cc45_48d0_425a_bc22_bc3284b49a29
is: SBO:0000252
is encoded by: hsa:728226
constant: false
type: Species
name: _728226_1_e
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR RDH1a
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.300
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
is: SBO:0000176
reversible: true
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.1.1.105
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is described by: ECO:0000269
name: retinol dehydrogenase (all-trans,NADPH)

http://identifiers.org/biomodels.db/MODEL1310110006#_ab7a1626_638d_4f87_a809_59dcc021a10c
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:NM 013421
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: _NM_013421_1_m

http://identifiers.org/biomodels.db/MODEL1310110006#_c536fa3d_dd7f_41fd_85b6_a38200a7174d
name: PEMT
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10400
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_31fcf585_76c8_40bf_8445_48b8f402d647
initial concentration: NaN
constant: false
name: _642502_1_c
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:642502
type: Species

metaR FACOAL1831
is: SBO:0000176
kinetic law: MODEL1310110006#
product: MODEL1310110006#
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110006#
type: Reaction
reversible: true
name: fatty-acid--CoA ligase
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_255fe9d0_b173_47cd_b0a4_08dfc5b80028
initial amount: NaN
is encoded by: hsa:7108
name: TM7SF2
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: O76062
initial concentration: NaN
boundary condition: true

metaR C80CPT1
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

metaM c12dc x
type: Species
is: HMDB11123
initial concentration: 1.0
notes: FORMULA: C19H34NO6 CHARGE: -1
constant: false
name: dodecanedioyl carnitine
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: C05279
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_galacglc13galacglcgal14acglcgalgluside_hs_g
type: Species
initial concentration: 1.0
is: CHEBI:26174
constant: false
boundary condition: false
name: nLc8Cer
has only substance units: false
initial amount: NaN
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
is: SBO:0000247

metaR CMPACNAtn
reactant: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
reversible: false
name: CMP-Sia nuclear export
is: SBO:0000185
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110006#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_dab58b16_3e4c_4cb9_932f_ea9fe16524c4
boundary condition: true
has only substance units: false
is encoded by: hsa:1757
is: A8K596
type: Species
name: SARDH
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR CYTDK1
is version of: http://identifiers.org/ec-code/2.7.1.48
kinetic law: MODEL1310110006#
reversible: false
fast: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000254
modifier: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
name: ATPcytidine 5-phosphotransferase
is: SBO:0000176

metaM HC00460 c
type: Species
is: CHEBI:58044
constant: false
is: SBO:0000247
name: 2,5-dihydroxybenzoate
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
has only substance units: false

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR r1570
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110006#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110006#
is: SBO:0000185
reactant: MODEL1310110006#

metaR r0753
modifier: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
is: SBO:0000176
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
reversible: true
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.85
is described by: ECO:0000000

metaR r0191
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
fast: false
is: SBO:0000176
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.24
reversible: false
modifier: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#

metaM h c
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: C00080
name: proton
initial concentration: 1.0
is: CHEBI:24636

metaM 2octdectecoa m
constant: false
initial concentration: 1.0
type: Species
name: 2,6,9,12-octadecatetraenoylcoa
initial amount: NaN
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_21132a4a_c694_488d_a46c_b77b4b05fcaa
constant: false
type: Species
has only substance units: false
name: ADH5
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:128
is: Q6IRT1
initial concentration: NaN

metaM arach c
constant: false
is: SBO:0000247
is: HMDB02212
type: Species
is: CHEBI:32360
initial amount: NaN
name: arachidate
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaM 3tetd7ecoacrn c
is: HMDB02014
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C21H39NO5 CHARGE: 0
name: 3-hydroxy tetradecenoyl-7-carnitine
type: Species
boundary condition: false
is: SBO:0000247

metaM lac L e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: (S)-lactate
has only substance units: false
is: CHEBI:16651
constant: false
is: HMDB00190
boundary condition: false
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177

metaR FACOAL1832
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
is described by: ECO:0000269
fast: false
reactant: MODEL1310110006#
type: Reaction
reversible: true
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C
is: SBO:0000176
kinetic law: MODEL1310110006#
product: MODEL1310110006#

metaM leuktrD4 e
name: Leukotriene D4
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28666
is: SBO:0000247
type: Species
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false
is: HMDB03080
boundary condition: false

metaR r0752
is: SBO:0000176
modifier: MODEL1310110006#
fast: false
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
reversible: true
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_dafdefa6_97a9_4fb3_af3c_1ffd63de1396
is: P20132
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:10993
name: SDS
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_f0af8b43_ca7a_4cfc_b465_6b770ee36ee2
is encoded by: hsa:3029
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: HAGH
constant: false
is: Q16775
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_d3565832_a08a_4ec7_96bb_c071e4fd12d7
name: AK1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:203
constant: false
is: P00568
type: Species
boundary condition: true
has only substance units: false

metaR r1571
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110006#

metaM sebacid c
notes: FORMULA: C10H16O4 CHARGE: -2
has only substance units: false
is: C08277
name: sebacicacid
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: HMDB00792

http://identifiers.org/biomodels.db/MODEL1310110006#_549fb4df_c765_444c_8061_0234c560ebd3
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q8NFW8
is encoded by: hsa:55907
name: CMAS
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_9941ef1c_4633_4d4e_a906_30814ef2f7c0
type: Species
is: SBO:0000252
name: COASY
is: Q13057
constant: false
initial amount: NaN
is encoded by: hsa:80347
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR FAOXC221C201x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaM gly c
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
name: Glycine
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:3339
type: Species
is: C00037
is: HMDB00123

metaR LSTO1r
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.21.6
fast: false
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
name: Lathosterol oxidase
reactant: MODEL1310110006#
type: Reaction

metaM akg x
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: CHEBI:16810
is: HMDB00208
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 2-oxoglutarate(2-)
type: Species
has only substance units: false

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_038e459e_62a3_4bcd_98a9_95754cef6436
has only substance units: false
is encoded by: hsa:BG035985
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: _BG035985_1_c
initial amount: NaN

metaM pglyc hs c
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
has only substance units: false
boundary condition: false
is: CHEBI:60523
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
name: phosphatidylglycerol(1-)
initial amount: NaN

metaM h e
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: C00080
initial concentration: 1.0
name: proton
is: CHEBI:24636
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_a7bdf81a_b520_48cc_af25_a4a372c9a9cf
name: PLCB2
has only substance units: false
is encoded by: hsa:5330
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q59F77
is: SBO:0000252
constant: false

metaR PAPStg
reversible: true
product: MODEL1310110006#
fast: false
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
name: 3'-Phosphoadenylyl sufate Golgi transport
modifier: MODEL1310110006#
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_5d836df1_3a89_4586_83b5_fd3d692e7c36
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaM arach e
is: HMDB02212
initial amount: NaN
type: Species
is: CHEBI:32360
name: arachidate
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102

metaM 3octdectecoa x
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355
name: 3,6,9,12-octadecatetraenoylcoa
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
type: Species

metaM 3tetd7ecoacrn e
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C21H39NO5 CHARGE: 0
is: SBO:0000247
name: 3-hydroxy tetradecenoyl-7-carnitine
boundary condition: false
is: HMDB02014

metaM 44mzym r
constant: false
initial amount: NaN
is: CHEBI:18364
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
name: 14-demethyllanosterol
is: HMDB01286

metaR EX sarcs LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sarcosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_fa373456_a1f5_495d_afaf_b94f1d85245b
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:80308
constant: false
name: FLAD1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_1f58c37b_09a4_4f5f_9dea_c411b22fd0b9
boundary condition: true
name: ENTPD1
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is: Q86VV3
is encoded by: hsa:953
initial amount: NaN

metaM h g
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:24636
name: proton
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_6ccde626_2d0d_467a_a1a5_fb0c4e92b7a1
initial concentration: NaN
has only substance units: false
name: TPI1P2
is encoded by: hsa:286016
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_6e9958d6_a5ca_4e3e_b2ef_c0892d599a39
initial concentration: NaN
boundary condition: true
has only substance units: false
name: HAS3
initial amount: NaN
type: Species
is: SBO:0000252
is: O00219
constant: false
is encoded by: hsa:3038

metaR SUBEACTD
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

metaM leuktrD4 c
name: Leukotriene D4
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:28666
is: HMDB03080
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951

http://identifiers.org/biomodels.db/MODEL1310110006#_26a10092_5e97_4b57_b390_db81663bd802
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is: Q5FWF5
is encoded by: hsa:114799
name: ESCO1
initial concentration: NaN
boundary condition: true

metaR C4DCe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of succinyl carnitine into the extra cellular space
type: Reaction

metaM lac L c
initial amount: NaN
name: (S)-lactate
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
boundary condition: false
constant: false
type: Species
is: HMDB00190
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16651

http://identifiers.org/biomodels.db/MODEL1310110006#_0e2e2bf8_4068_43eb_8ae5_197f1c1c6d8a
type: Species
is encoded by: hsa:3033
initial amount: NaN
boundary condition: true
name: HADH
is: SBO:0000252
has only substance units: false
is: Q16836
initial concentration: NaN
constant: false

metaM thyox L e
name: L-thyroxine
boundary condition: false
is: CHEBI:18332
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00248
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849

metaM lnlncacrn m
name: alpha-linolenyl carnitine
is: HMDB06319
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaR EX 9 cis retfa LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid 9-cis-retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_2caf3b2e_689c_49ce_ac4e_a24178ed3c5b
initial amount: NaN
boundary condition: true
is: E9KL44
constant: false
has only substance units: false
initial concentration: NaN
name: HADHA
type: Species
is encoded by: hsa:3030
is: SBO:0000252

metaM HC01115 c
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
is: SBO:0000247
name: NeuNGc
initial concentration: 1.0
is: CHEBI:29025
type: Species

metaR UDPGLCAter
type: Reaction
reactant: MODEL1310110006#
is: SBO:0000185
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000269
fast: false
reversible: true

metaM 4hphac c
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
is: CHEBI:48999
name: 4-hydroxyphenylacetate
constant: false
is: HMDB00020
boundary condition: false
type: Species

metaM trdrd m
boundary condition: false
is: SBO:0000247
name: Reduced thioredoxin
constant: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: CHEBI:15967
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_8b41c921_458a_41a2_aec7_39053b9c35d2
is: SBO:0000252
name: ACE
has only substance units: false
is: B4DKH4
is encoded by: hsa:1636
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true

metaR RE3244R
reversible: true
reactant: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110006#
modifier: MODEL1310110006#
name: RE3244
type: Reaction
kinetic law: MODEL1310110006#

metaM fad x
has only substance units: false
is: HMDB01248
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
name: Flavin adenine dinucleotide oxidized
type: Species
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: CHEBI:16238
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_7cea75ab_cc6a_471e_979d_ce4e684a8115
is: O00764
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: PDXK
boundary condition: true
type: Species
is encoded by: hsa:8566
initial amount: NaN

metaR r0829
is version of: http://identifiers.org/ec-code/4.1.1.37
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110006#
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110006#_f459054b_c2ea_4bbc_b187_5d2afbf5257c
name: B3GALT5
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10317
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_3eeb994f_e946_4e25_ab8b_f389274d94d4
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:AI620219
name: _AI620219_1_e
constant: false
has only substance units: false
is: SBO:0000252

metaR HEXCCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
type: Reaction
product: MODEL1310110006#
name: fatty acid intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110006#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110006#

metaM udpg r
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
constant: false
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00286
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
initial amount: NaN
is: CHEBI:58367
initial concentration: 1.0

metaR VALLAT1tc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaR NDPK3n
reactant: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_1f46a18e_b7b8_4b1a_994e_e262d1848ba6
is encoded by: hsa:18
type: Species
is: P80404
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ABAT
is: SBO:0000252
has only substance units: false
constant: false

metaR ACGAMPM
type: Reaction
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000269
product: MODEL1310110006#
name: phosphoacetylglucosamine mutase
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/5.4.2.3

metaR LGNCt
name: fatty acid transport via diffusion
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110006#
type: Reaction
reversible: true
kinetic law: MODEL1310110006#
fast: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110006#_4ec52dd2_e5f7_4f44_8e4d_2a79b253bde4
name: AGPAT4
constant: false
boundary condition: true
is: Q9NRZ5
is: SBO:0000252
is encoded by: hsa:56895
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN

metaM HC01405 m
is: SBO:0000247
name: (S)-Hydroxyoctanoyl-CoA
constant: false
is: CHEBI:28632
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266

metaR r2142
kinetic law: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reversible: true

metaR r0974
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110006#
name: Active transport
reactant: MODEL1310110006#
type: Reaction
reversible: true
product: MODEL1310110006#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_cca3c3dd_0ec5_48a8_8b7f_e392c42f6d66
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:4694
initial concentration: NaN
has only substance units: false
type: Species
name: NDUFA1
constant: false
is: Q6IBB5

http://identifiers.org/biomodels.db/MODEL1310110006#_0dcb612e_29b3_41ab_bf08_151587a7f3cc
is encoded by: hsa:9060
is: SBO:0000252
boundary condition: true
name: PAPSS2
is: O95340
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species

metaM dcyt n
is: HMDB00014
has only substance units: false
initial concentration: 1.0
name: 2'-deoxycytidine
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: CHEBI:15698
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false

metaM 4hphac e
is: SBO:0000247
is: CHEBI:48999
initial concentration: 1.0
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
has only substance units: false
constant: false
is: HMDB00020
name: 4-hydroxyphenylacetate
type: Species
boundary condition: false
initial amount: NaN

metaM inost e
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:17268
is: HMDB00211
boundary condition: false
constant: false
name: myo-inositol
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137

metaM ptdca e
name: pentadecanoate
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
has only substance units: false
is: HMDB00826
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/22169126
type: Species
initial concentration: 1.0

metaM glygn5 e
is: CHEBI:17754
notes: FORMULA: C12H21O11X CHARGE: 0
type: Species
boundary condition: false
is: HMDB00131
initial amount: NaN
has only substance units: false
constant: false
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
is: C00116
is: SBO:0000247
initial concentration: 1.0

metaR NDPK3m
fast: false
is: SBO:0000176
is described by: ECO:0000254
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
modifier: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110006#_40374a08_ff95_4aac_bd68_bd297531e4ac
name: COX6B2
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:125965
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q6YFQ2
type: Species

metaR r2141
kinetic law: MODEL1310110006#
type: Reaction
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
reactant: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110006#_fece183c_2aa9_467e_9226_46b143916a2f
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: A5JJ20
is: SBO:0000252
type: Species
boundary condition: true
name: SLC4A4
constant: false
is encoded by: hsa:8671

metaR r0193
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
fast: false
kinetic law: MODEL1310110006#
is: SBO:0000176
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110006#

metaR r0973
type: Reaction
reversible: true
product: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
name: Facilitated diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reactant: MODEL1310110006#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110006#_58949c86_a2d4_4c0c_a9e2_ff46762fbbad
boundary condition: true
is encoded by: hsa:2592
constant: false
has only substance units: false
is: B4E097
is: SBO:0000252
initial amount: NaN
name: GALT
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_cb78b9a3_aa2c_43df_b62e_b2d03182d65b
name: SDHD
has only substance units: false
initial amount: NaN
is: O14521
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:6392
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_metaR_EX_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIA glycolipid exchange
type: Reaction

metaR B3GNT314g
kinetic law: MODEL1310110006#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
modifier: MODEL1310110006#
is described by: ECO:0000254
type: Reaction
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
reactant: MODEL1310110006#
is: SBO:0000176
fast: false
reversible: false

metaR FAOXC140
fast: false
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
is described by: ECO:0000269
kinetic law: MODEL1310110006#
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM sebcoa x
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: sebacoylcoa
is: http://identifiers.org/pubchem.compound/16019966

http://identifiers.org/biomodels.db/MODEL1310110006#_729fdf6a_b0e9_4339_8b1f_5b8e9bc2c28d
type: Species
is: SBO:0000252
is encoded by: hsa:26
constant: false
name: ABP1
has only substance units: false
is: P19801
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_d8055937_ef4f_4e4b_ab12_2087e34668d8
has only substance units: false
initial concentration: NaN
name: B3GNT2
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is: Q9NY97
is encoded by: hsa:10678
type: Species

metaM cholcoa x
constant: false
name: choloyl-CoA(4-)
initial amount: NaN
is: SBO:0000247
is: CHEBI:57373
has only substance units: false
type: Species
boundary condition: false
is: HMDB01374
initial concentration: 1.0
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794

metaR PROt4 2 r
is described by: ECO:0000006
fast: false
modifier: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
name: Proline transport (sodium symport) (2:1)
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaR r2140
modifier: MODEL1310110006#
reactant: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM inost c
constant: false
is: HMDB00211
initial amount: NaN
is: SBO:0000247
is: CHEBI:17268
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
name: myo-inositol
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_4cc4075d_2e19_4f5c_9cf6_6010fbb6a833
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:686
name: BTD
boundary condition: true
initial concentration: NaN
is: P43251
constant: false
has only substance units: false

metaR RE3326M
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.2.4.4
fast: false
name: RE3326
type: Reaction
is described by: ECO:0000000
product: MODEL1310110006#
is: SBO:0000176
reversible: true
modifier: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:

metaR CYSGLYexR
product: MODEL1310110006#
name: L-cysteine/glycine reversible exchanger
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
fast: false
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_48169658_4fed_4149_a28c_08c209f9b82d
has only substance units: false
initial amount: NaN
type: Species
name: COX6A1
boundary condition: true
is: SBO:0000252
is: P12074
is encoded by: hsa:1337
initial concentration: NaN
constant: false

metaR GLUPROASCT1
fast: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
name: glutamate intake by system ASCT-1 transporter
is described by: ECO:0000134
kinetic law: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
reversible: false

metaR NDPK9
type: Reaction
modifier: MODEL1310110006#
is described by: ECO:0000269
kinetic law: MODEL1310110006#
name: nucleoside-diphosphate kinase (ATP:IDP)
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
reversible: true
is: SBO:0000176
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110006#

metaM CE5236 c
has only substance units: false
is: CHEBI:28002
is: HMDB03952
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
initial amount: NaN
type: Species
boundary condition: false
name: O2'-4a-cyclic-tetrahydrobiopterin
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR ITCOALm
is: SBO:0000176
reversible: true
is described by: ECO:0000212
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.5
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
fast: false
reactant: MODEL1310110006#
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_f0eabc68_7303_4f98_8812_85fca1702a9b
is encoded by: hsa:4200
is: SBO:0000252
is: P23368
name: ME2
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM tethex3 c
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
initial amount: NaN
name: tetracosahexaenoic acid, n-3
boundary condition: false
is: HMDB02007
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false

metaM g2m8mpdol L r
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C1900H3128N20O720P20 CHARGE: -20
is: C05870
type: Species
boundary condition: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaM 34dhoxmand c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: 3,4-Dihydroxymandelate
type: Species
is: HMDB01866
is: CHEBI:27637
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
constant: false

metaM h l
has only substance units: false
initial amount: NaN
is: CHEBI:24636
type: Species
initial concentration: 1.0
is: C00080
is: http://identifiers.org/pubchem.compound/3380
notes: FORMULA: H CHARGE: 1 INCHI: "
name: proton
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_703b5c63_25f6_4a09_a127_3bd4b3ccbac8
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: COX6C
is: P09669
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:1345

metaR S6T8g
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
reactant: MODEL1310110006#
fast: false
product: MODEL1310110006#
is described by: ECO:0000000
modifier: MODEL1310110006#

metaM CE5117 m
is: SBO:0000247
constant: false
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
has only substance units: false
initial amount: NaN
is: CHEBI:57923
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
type: Species
initial concentration: 1.0

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_8d4ab583_a2e4_4d8b_ae5f_9cc03bd9b0f2
boundary condition: true
name: LDHC
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3948
type: Species

metaR RE3568C
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110006#
type: Reaction
reversible: true
name: RE3568
fast: false
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_90bdb87f_1312_41e9_83d6_0138daa2957f
is: SBO:0000252
type: Species
is encoded by: hsa:4696
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
name: NDUFA3
constant: false
is: O95167

metaR ACITL
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.3.8
product: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
name: ATP-Citrate lyase

metaR CMPACNAtg
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
reactant: MODEL1310110006#
is: SBO:0000185
modifier: MODEL1310110006#
type: Reaction
name: CMP-Sia Golgi transport via CMP antiport
fast: false
reversible: true
kinetic law: MODEL1310110006#
is described by: ECO:0000269
product: MODEL1310110006#

metaR FAOXC205C185m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaM h m
name: proton
is: SBO:0000247
is: C00080
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN
initial concentration: 1.0
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
type: Species
boundary condition: false
constant: false

metaR FAOXC12DCc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

metaR NACHEXA22ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is: SBO:0000176
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_636e31cb_adef_4359_913f_bd648cb2c733
initial amount: NaN
is: P05062
constant: false
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:229
name: ALDOB
is: SBO:0000252

metaM tethex3 e
constant: false
is: SBO:0000247
name: tetracosahexaenoic acid, n-3
initial amount: NaN
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
has only substance units: false
is: HMDB02007
boundary condition: false
type: Species
initial concentration: 1.0

metaM 34dhmald m
boundary condition: false
constant: false
type: Species
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: HMDB06242
initial amount: NaN
name: 3,4-Dihydroxymandelaldehyde
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7903
is: C05577
has only substance units: false
initial concentration: 1.0

metaM retinal cis 13 r
constant: false
is: HMDB06220
has only substance units: false
name: 13-cis-retinal
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: CHEBI:45487
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species

metaR NDPK7
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dCDP)
product: MODEL1310110006#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_d4bb7645_57d2_4966_8658_69eac717ee64
initial amount: NaN
name: PDE5A
is: SBO:0000252
initial concentration: NaN
is: G5E9C5
is encoded by: hsa:8654
boundary condition: true
has only substance units: false
constant: false
type: Species

metaM h n
is: CHEBI:24636
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
name: proton
boundary condition: false
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

metaM cs a deg2 l
is: CHEBI:15748
notes: FORMULA: C37H55NO38S2 CHARGE: -4
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 2
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00127
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_f1fb824f_af39_427a_9107_e4993517ae08
is: P14410
name: SI
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6476
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_735b305a_2b11_413e_8ba1_cffee23b0cc2
name: PLCB3
constant: false
has only substance units: false
is: G5E960
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:5331
initial concentration: NaN
initial amount: NaN

metaR SRTNt6 2 r
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
type: Reaction
fast: false
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110006#
is: SBO:0000185
reversible: true
modifier: MODEL1310110006#
is described by: ECO:0000269
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_d154b99b_8616_484c_ba2b_9e9c761e82e4
is: SBO:0000252
is encoded by: hsa:4713
type: Species
constant: false
has only substance units: false
is: P17568
name: NDUFB7
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR r0196
kinetic law: MODEL1310110006#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
modifier: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
reversible: true
product: MODEL1310110006#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR FACOAL181i
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
name: C181 fatty acid activation
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110006#
product: MODEL1310110006#

metaR S6T16g
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
reactant: MODEL1310110006#
fast: false
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_7c3622ed_d4e2_4d20_b621_be51b9a34678
is: O95168
initial concentration: NaN
is encoded by: hsa:4710
name: NDUFB4
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252

metaM ocde9ecoa x
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: 9-octadecenoylcoa
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355

metaR NDPK8
reversible: true
is: SBO:0000176
reactant: MODEL1310110006#
fast: false
product: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
name: Nucleoside-diphosphate kinase (ATP:dADP)
modifier: MODEL1310110006#
is described by: ECO:0000269

metaR PI45PLC
reversible: false
product: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reactant: MODEL1310110006#
is described by: ECO:0000000
fast: false
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.11

metaM ala B m
is: HMDB00056
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:16958
name: beta-alanine
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_bc032df9_609c_4976_af3f_482583fe2769
initial amount: NaN
name: GLS2
is encoded by: hsa:27165
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
has only substance units: false
is: Q9UI32

http://identifiers.org/biomodels.db/MODEL1310110006#_0605c4bc_36fc_48ab_9173_6571a119b34a
is encoded by: hsa:2986
constant: false
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: P51841
initial concentration: NaN
name: GUCY2F

http://identifiers.org/biomodels.db/MODEL1310110006#_abd4850a_57da_41ca_a9d9_05b0e7331fbc
boundary condition: true
has only substance units: false
name: AADAT
constant: false
initial concentration: NaN
initial amount: NaN
is: Q8N5Z0
type: Species
is: SBO:0000252
is encoded by: hsa:51166

metaM akg m
is: HMDB00208
is: SBO:0000247
type: Species
name: 2-Oxoglutarate
is: C00026
boundary condition: false
is: CHEBI:16810
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026

metaR r0400
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000176
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
modifier: MODEL1310110006#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.2.4.4
is described by: ECO:0000000
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_bca666cf_aefd_48ef_b8d7_443d713ad2be
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q8TB61
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:347734
boundary condition: true
name: SLC35B2

metaR UMPK5n
is: SBO:0000176
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
reversible: true
name: UMP kinase (dATP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_60048fff_8db9_40f7_be10_ff8ab4f1476e
is: O60476
initial concentration: NaN
is: SBO:0000252
name: MAN1A2
has only substance units: false
is encoded by: hsa:10905
type: Species
boundary condition: true
constant: false
initial amount: NaN

metaR SMPD4
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
is: SBO:0000176
is described by: ECO:0000000
name: sphingomyelinase
kinetic law: MODEL1310110006#
product: MODEL1310110006#
fast: false
type: Reaction
reactant: MODEL1310110006#

metaM pglyc hs e
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
initial concentration: 1.0
type: Species
is: CHEBI:60523
name: phosphatidylglycerol(1-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_5d9b7129_3f51_4e8a_b29b_126cabb5643b
name: HK1
type: Species
is encoded by: hsa:3098
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is: P19367
boundary condition: true
has only substance units: false

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR DADAe
product: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
modifier: MODEL1310110006#
name: Deoxyadenosine deaminase, extracellular
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.4
is described by: ECO:0000269

metaM c6crn x
is: SBO:0000247
type: Species
is: HMDB00705
constant: false
boundary condition: false
initial concentration: 1.0
name: hexanoyl carnitine
notes: FORMULA: C13H25NO4 CHARGE: 0
initial amount: NaN
has only substance units: false

metaM 1glyc hs e
notes: FORMULA: C6H13O7PFULLRCO2 CHARGE: -1
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00972
name: 1 acyl phosphoglycerol
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:57454

metaR FAOXC121x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

metaM 13dpg c
is: http://identifiers.org/pubchem.compound/3535
is: HMDB01270
type: Species
is: C00236
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:57604
has only substance units: false
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
initial amount: NaN
is: SBO:0000247
name: 3-Phospho-D-glyceroyl phosphate

metaR CYTDK2m
reactant: MODEL1310110006#
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
product: MODEL1310110006#
name: cytidine kinase (ATP), mitochondrial
is: SBO:0000176

metaM adp c
boundary condition: false
name: ADP
initial concentration: 1.0
is: HMDB01341
is: http://identifiers.org/pubchem.compound/3310
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C00008
is: CHEBI:16761
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_3127f041_d06b_460c_a4ca_aa912f3d7970
type: Species
is: A6NN98
constant: false
name: MTMR2
is encoded by: hsa:8898
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false

metaR HSAT2ly
product: MODEL1310110006#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reactant: MODEL1310110006#
reversible: false
fast: false

metaR BAMPPALDOX
kinetic law: MODEL1310110006#
reversible: false
type: Reaction
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
fast: false
is described by: ECO:0000212
product: MODEL1310110006#
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR H3MTer L
product: MODEL1310110006#
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110006#
name: H3 mannosyltransferase, endoplasmic reticulum
kinetic law: MODEL1310110006#
reversible: false
is: SBO:0000176
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD

metaR SCPx
reversible: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
name: peroxisomal thiolase 2
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.176
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
fast: false

metaM thyox L c
boundary condition: false
name: L-thyroxine
has only substance units: false
constant: false
is: CHEBI:18332
is: HMDB00248
is: SBO:0000247
type: Species
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_323b906b_2766_40f8_8448_b431c0889504
initial concentration: NaN
type: Species
name: ALAS1
has only substance units: false
boundary condition: true
is encoded by: hsa:211
constant: false
is: SBO:0000252
is: P13196
initial amount: NaN

metaM trdrd c
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: C00342
name: Reduced thioredoxin
is: CHEBI:15967
has only substance units: false
constant: false
initial concentration: 1.0

metaR SR5ARr
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
kinetic law: MODEL1310110006#
is described by: ECO:0000134
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
fast: false
modifier: MODEL1310110006#
product: MODEL1310110006#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.5
reactant: MODEL1310110006#
is: SBO:0000176

metaR AK2LGCHOLt
reversible: true
is: SBO:0000185
is described by: ECO:0000269
fast: false
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:
type: Reaction
reactant: MODEL1310110006#
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_8a90da3d_a6c5_40a9_a8e9_d74ccea0fe8c
initial concentration: NaN
constant: false
is: Q96CA6
boundary condition: true
name: ACAA1
has only substance units: false
is encoded by: hsa:30
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_231466f4_8fb0_4962_8918_e7bac6c2e630
name: PAPSS1
is encoded by: hsa:9061
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: O43252

metaR COAtg
reversible: true
is: SBO:0000185
reactant: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
name: CoA transport in Golgi via diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110006#
kinetic law: MODEL1310110006#

metaR ILETA
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
modifier: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
name: isoleucine transaminase
is described by: ECO:0000269
reversible: true
product: MODEL1310110006#

metaM h r
is: C00080
is: SBO:0000247
is: CHEBI:24636
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
constant: false
has only substance units: false

metaM lnlncacrn c
constant: false
is: SBO:0000247
initial concentration: 1.0
name: alpha-linolenyl carnitine
has only substance units: false
type: Species
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
initial amount: NaN
boundary condition: false
is: HMDB06319

metaM gly e
initial amount: NaN
is: C00037
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: CHEBI:3339
initial concentration: 1.0
boundary condition: false
name: Glycine
constant: false
is: SBO:0000247
is: HMDB00123
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_41698df0_ce44_4332_acc3_c85487524d2b
is: SBO:0000252
type: Species
name: GK3P
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2713

http://identifiers.org/biomodels.db/MODEL1310110006#_162b5deb_8654_46a8_abca_3a8e62aae614
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: Q13907
boundary condition: true
type: Species
is encoded by: hsa:3422
initial amount: NaN
name: IDI1

http://identifiers.org/biomodels.db/MODEL1310110006#_69de4031_8318_4561_a1bd_95fef0bd9d95
type: Species
has only substance units: false
name: ETFA:ETFB
constant: false
has part: P38117
is: SBO:0000297
initial concentration: NaN
is encoded by: hsa:2109
boundary condition: true
initial amount: NaN

metaR LINKDEG4ly
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: false
name: degradation of proteoglycan linkage region, lysosomal
fast: false
is: SBO:0000176
product: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
type: Reaction

metaR NTD2e
product: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:2840110 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is described by: ECO:0000134
modifier: MODEL1310110006#
reversible: false
name: 5'-nucleotidase (UMP), extracellular
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_887427a9_c78c_45a3_a960_f91304130c75
initial concentration: NaN
type: Species
is: O00400
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
name: SLC33A1
is encoded by: hsa:9197

metaR PGLer
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.47
modifier: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
reversible: false
name: 6-phosphogluconolactonase, endoplasmic reticulum
kinetic law: MODEL1310110006#

metaR KHK2
reactant: MODEL1310110006#
reversible: false
product: MODEL1310110006#
is: SBO:0000176
modifier: MODEL1310110006#
is described by: ECO:0000269
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.3
name: ketohexokinase (D-xylulose)

metaM 2ddecdicoa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: SBO:0000247
is: HMDB11123
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
constant: false
is: C05279
name: 2,6-dodecadienoylcoa
initial amount: NaN

metaM tdcoa c
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial concentration: 1.0
constant: false
is: C02593
is: HMDB01521
type: Species
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: SBO:0000247
is: CHEBI:57385
boundary condition: false
initial amount: NaN
has only substance units: false

metaM dcsptn1 e
boundary condition: false
is: HMDB13123
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
is: http://identifiers.org/pubchem.compound/5282848
type: Species
is: SBO:0000247
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoic acid

metaR TRDR
type: Reaction
modifier: MODEL1310110006#
name: thioredoxin reductase (NADPH)
reactant: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.8.1.9
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
is: SBO:0000176
product: MODEL1310110006#
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_d20878b1_9d15_4bde_9feb_b8601fdff923
is: E7EPT3
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:501
is: SBO:0000252
initial concentration: NaN
name: ALDH7A1
boundary condition: true

metaM m8masn r
type: Species
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false
is: C05876
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C70H117N2O55X CHARGE: 0

metaR r1669
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
is described by: ECO:0000000
product: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false

metaM nad r
has only substance units: false
type: Species
is: HMDB00902
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: CHEBI:57540
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
name: NAD(1-)
boundary condition: false

metaR r2371
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
product: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
kinetic law: MODEL1310110006#

metaM ksi pre11 g
initial concentration: 1.0
constant: false
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
is: CHEBI:28067
has only substance units: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 11
boundary condition: false
type: Species
is: SBO:0000247

metaM ddece1crn c
constant: false
is: HMDB03712
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H35NO4 CHARGE: 0
has only substance units: false
type: Species
name: dodecenoyl carnitine

metaR LNSTLSr
modifier: MODEL1310110006#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.4.99.7
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
product: MODEL1310110006#
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110006#
reversible: false
name: lanosterol synthase

metaR H2O2t
kinetic law: MODEL1310110006#
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: hydrogen peroxide transport via diffusion
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF

http://identifiers.org/biomodels.db/MODEL1310110006#_4f7bd3b8_68be_4278_b7d9_d7a630b9928e
type: Species
is: Q8TE04
is: SBO:0000252
has only substance units: false
name: PANK1
initial amount: NaN
is encoded by: hsa:53354
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_804a12f4_108a_430e_ad03_a6a4684d5dc0
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _AI469183_1_x
has only substance units: false
type: Species
is encoded by: hsa:AI469183

http://identifiers.org/biomodels.db/MODEL1310110006#_ba0eaa63_0e83_4411_a01b_d7c553d0ad29
is encoded by: hsa:3030
initial concentration: NaN
name: HADHA
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: E9KL44
has only substance units: false
constant: false

metaM 4aphdob c
initial amount: NaN
is: CHEBI:58147
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
constant: false
has only substance units: false
type: Species
is: HMDB00978
is: SBO:0000247
name: 4-(2-aminophenyl)-2,4-dioxobutanoate

metaM dutp n
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: CHEBI:17625
is: HMDB01191
is: SBO:0000247
initial concentration: 1.0
constant: false
name: dUTP
initial amount: NaN

metaR SPH1Pte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110006#
name: sph1p transport
reactant: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110006#_bf389e8b_b2b3_44a7_b5e7_8f24e8aaa90e
name: HMGCS2
is: P54868
type: Species
boundary condition: true
is encoded by: hsa:3158
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false

metaR RE2814R
name: RE2814
fast: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
reversible: true
product: MODEL1310110006#
is described by: ECO:0000000
type: Reaction

metaM CE5121 m
name: trans-3-decenoyl-CoA
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:57449
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121

metaR FPGS5m
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.3.2.17
name: folylpolyglutamate synthetase (DHF), mitochondrial
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
reactant: MODEL1310110006#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
modifier: MODEL1310110006#
product: MODEL1310110006#

metaM leu L e
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
name: L-leucine
is: HMDB00687
is: CHEBI:15603

metaM pail5p hs n
has only substance units: false
is: SBO:0000247
is: CHEBI:57795
initial concentration: 1.0
constant: false
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial amount: NaN
type: Species

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

metaM gbside hs l
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: SBO:0000247
is: CHEBI:18259
name: globoside
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0

metaM asp L c
is: SBO:0000247
name: L-aspartate(1-)
type: Species
is: HMDB00191
boundary condition: false
constant: false
is: CHEBI:29991
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055

metaR GLCt4
type: Reaction
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110006#
fast: false
name: glucose transport via sodium symport
kinetic law: MODEL1310110006#
reversible: true
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_c86d8165_e9bf_45fa_bc32_e4d1947836d0
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5805
is: Q03393
is: SBO:0000252
name: PTS
type: Species

metaM ksii core2 deg7 l
name: keratan sulfate II (core 2-linked), degradation product 7
has only substance units: false
is: CHEBI:57455
notes: FORMULA: C44H73N4O30X CHARGE: 0
initial amount: NaN
is: HMDB01354
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false

metaM dolmanp L c
name: Dolichyl phosphate D-mannose, human liver homolog
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:15809
type: Species
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110006#_86224fc1_9b48_4be0_8e24_ce3e984d1528
is: SBO:0000297
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN
has part: Q9UPY5
is encoded by: hsa:23657
has only substance units: false
name: SLC7A11:SLC3A2

metaM dutp m
is: HMDB01191
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false
is: CHEBI:17625
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: dUTP

metaR DGULND
is: SBO:0000176
name: dehydro-L-gulonate decarboxylase
reactant: MODEL1310110006#
fast: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110006#
type: Reaction

metaR r1421
is described by: ECO:0000000
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
reversible: true
name: Free diffusion
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
fast: false

metaR RE3556C
type: Reaction
reversible: true
reactant: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
name: RE3556
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:

metaR r2373
fast: false
product: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_06d91d46_8659_4620_918b_fb3b7e1d222b
has only substance units: false
is: P00918
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:760
initial concentration: NaN
constant: false
name: CA2

http://identifiers.org/biomodels.db/MODEL1310110006#_bde71e12_2ce4_41c1_a1d9_9ce3c55ec26d
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
name: CPT1B
is encoded by: hsa:1375
is: SBO:0000252
is: Q92523
initial amount: NaN

metaM cyan e
is: CHEBI:18407
is: HMDB02084
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
is: SBO:0000247
type: Species
name: hydrogen cyanide
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false

metaM ddece1crn e
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C02838
notes: FORMULA: C19H35NO4 CHARGE: 0
has only substance units: false
type: Species
constant: false
is: HMDB00791
name: dodecenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110006#_f594a12b_75ee_4ed7_94f9_433aa5197c84
is: G3V5N0
name: FUT8
initial amount: NaN
is encoded by: hsa:2530
type: Species
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r1551
fast: false
type: Reaction
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110006#
product: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185

metaM asp L e
type: Species
constant: false
name: L-aspartate(1-)
is: CHEBI:29991
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00191
is: SBO:0000247
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaR r2372
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
type: Reaction
reactant: MODEL1310110006#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185

metaR MI145PK
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.127
type: Reaction
name: inositol-1,4,5-trisphosphate 3-kinase
modifier: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000269
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_2b2c5934_4842_4fb3_bca0_3096c1278542
is encoded by: hsa:587
constant: false
is: SBO:0000252
type: Species
is: O15382
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: BCAT2

metaR RE2974C
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
type: Reaction
fast: false
name: RE2974
is version of: http://identifiers.org/ec-code/2.7.1.149
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.68
modifier: MODEL1310110006#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_68a34ed9_df21_4257_89c7_7afe40dc7cbf
boundary condition: true
type: Species
is: Q6TCH8
is: SBO:0000252
initial concentration: NaN
name: ME3
initial amount: NaN
is encoded by: hsa:10873
has only substance units: false
constant: false

metaM leu L c
is: HMDB00687
initial concentration: 1.0
is: CHEBI:15603
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
constant: false
boundary condition: false
initial amount: NaN
name: L-leucine
type: Species

metaR HPDCAt
kinetic law: MODEL1310110006#
is: SBO:0000185
reactant: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
product: MODEL1310110006#
reversible: true
is described by: ECO:0000000
type: Reaction
name: fatty acid transport via diffusion

metaM fadh2 c
initial amount: NaN
constant: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
has only substance units: false
initial concentration: 1.0
name: FADH2(2-)
is: HMDB01197
is: SBO:0000247
is: CHEBI:58307
type: Species
boundary condition: false

metaR LEUKTRF4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110006#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
name: leukotriene F4 transport
kinetic law: MODEL1310110006#
product: MODEL1310110006#
fast: false

metaR r1552
kinetic law: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110006#
is: SBO:0000185
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000

metaR r1665
product: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_da3945cb_38c4_49b4_9901_abb2c888b3dc
name: PIGN
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:23556
initial amount: NaN
is: SBO:0000252

metaR MI145PP
reactant: MODEL1310110006#
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.36
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.86
name: inositol-1,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.56
reversible: false
type: Reaction

metaR EX galacglcgalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-GlcNAc-Gal globoside (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_4b821fc5_b695_4454_b4d2_e788b1dec341
type: Species
boundary condition: true
constant: false
name: PDE8B
is encoded by: hsa:8622
is: O95263
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR G14T10g
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110006#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
product: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22

http://identifiers.org/biomodels.db/MODEL1310110006#_d7425429_a139_4d3b_a97f_8eb635738ed8
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:LOC647190
name: _LOC647190_1_c
is: SBO:0000252
has only substance units: false

metaR NACHEX26ly
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110006#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_5c10df07_dadd_479f_bcfa_bf82433c2e0c
name: FUCA1
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:2517
is: P04066
type: Species
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_c455084a_46d1_4a3b_8223_93c6de8c0e75
initial concentration: NaN
is encoded by: hsa:257068
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is: Q0VAA5
name: PLCXD2

metaM gbside hs g
constant: false
is: CHEBI:18259
initial amount: NaN
is: SBO:0000247
name: globoside
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
has only substance units: false

metaM cyan c
constant: false
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial concentration: 1.0
name: hydrogen cyanide
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:18407
is: HMDB02084
initial amount: NaN
type: Species

metaR r1553
reactant: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
fast: false
kinetic law: MODEL1310110006#

metaM crm hs r
constant: false
type: Species
name: N-acylsphingosine
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247

metaM ach n
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15355
has only substance units: false
is: HMDB00895
name: acetylcholine

metaR r1666
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110006#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110006#

metaR DSAT
reversible: false
name: dihydrosphingosine N-acyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
reactant: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
fast: false
type: Reaction

metaR FAOXC183C163Gm
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_f65bd721_3c0e_4a15_9e3f_a534add2d90f
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q9NRR6
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:56623
name: INPP5E

metaM thcholstoic x
is: CHEBI:18402
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB03873
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
type: Species

metaR FUT99g
reversible: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.152
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
name: Alpha-(1,3)-fucosyltransferase
modifier: MODEL1310110006#
fast: false
is: SBO:0000176

metaM ivcoa m
type: Species
initial concentration: 1.0
is: HMDB01113
constant: false
name: Isovaleryl-CoA
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
is: CHEBI:57345
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_e5e22260_0269_4b48_98c5_b25fc70056b5
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5334
name: PLCL1
initial concentration: NaN
type: Species
constant: false
is: Q15111

http://identifiers.org/biomodels.db/MODEL1310110006#_de195de7_9e5a_49c0_a438_92c212c13ca4
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is: P36969
boundary condition: true
is encoded by: hsa:2879
initial concentration: NaN
name: GPX4
has only substance units: false

metaR r1667
type: Reaction
fast: false
product: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaR COAtr
kinetic law: MODEL1310110006#
reversible: true
name: COA transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110006#
product: MODEL1310110006#

metaM CE4795 x
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,18-21,28-30,34-36,40,51-52H,4-7,10,13,16-17,22-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,19-18-,21-20+/t30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4795
constant: false
has only substance units: false
is: CHEBI:57923
name: 2-trans-cis,cis,cis,cis-4,8,11,14-eicosapentaenoyl-CoA
boundary condition: false

metaM ksi pre34 g
name: keratan sulfate I biosynthesis, precursor 34
boundary condition: false
is: HMDB00175
is: CHEBI:58053
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: C00130

metaR NACHEX23ly
kinetic law: MODEL1310110006#
reversible: false
fast: false
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110006#
is: SBO:0000176
type: Reaction
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal

metaR r1554
reactant: MODEL1310110006#
is: SBO:0000185
kinetic law: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true

metaM HC01610 e
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
is: CHEBI:28607
boundary condition: false
name: CoproporphyrinogenI
initial concentration: 1.0
has only substance units: false
constant: false

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_48d1537c_e6af_4d29_891d_42d52c61658f
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P51648
has only substance units: false
initial concentration: NaN
is encoded by: hsa:224
constant: false
type: Species
name: ALDH3A2

metaR DMNONCOACRNCPT1
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
is described by: ECO:0000000
product: MODEL1310110006#
is: SBO:0000176
name: DMNONCOACRNCPT1
kinetic law: MODEL1310110006#
type: Reaction
reversible: true
reactant: MODEL1310110006#
fast: false

metaM itp n
boundary condition: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: SBO:0000247
constant: false
has only substance units: false
name: ITP(3-)
is: CHEBI:57614
initial amount: NaN
is: HMDB00189
initial concentration: 1.0
type: Species

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaM fad m
is: C00016
boundary condition: false
is: CHEBI:16238
initial amount: NaN
name: Flavin adenine dinucleotide oxidized
is: HMDB01248
initial concentration: 1.0
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: SBO:0000247
type: Species
constant: false
has only substance units: false

metaM nad m
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0
has only substance units: false
is: C00003
constant: false
is: http://identifiers.org/pubchem.compound/3305
type: Species
initial amount: NaN
is: HMDB00902
is: SBO:0000247
boundary condition: false
is: CHEBI:57540

metaR HPACtr
is: SBO:0000185
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
name: hydroxyphenylacetate transport via diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
fast: false
reversible: true
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_0f7c86c0_a555_4112_8e1c_efc9f339cda1
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is: B7Z5G2
has only substance units: false
name: GBA
boundary condition: true
initial amount: NaN
is encoded by: hsa:2629

metaR r1668
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110006#
type: Reaction
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
product: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185
fast: false

metaR NCKt
reversible: true
fast: false
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
is: SBO:0000185
name: Na+/Ca2+-K+ exchange
is described by: ECO:0000269

metaR SO4t4 2
type: Reaction
reactant: MODEL1310110006#
product: MODEL1310110006#
modifier: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
fast: false
is: SBO:0000185
kinetic law: MODEL1310110006#
is described by: ECO:0000269
name: sulfate transport via sodium symport

metaM udpg e
is: SBO:0000247
has only substance units: false
is: CHEBI:58367
is: HMDB00286
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate

metaR COAtp
name: coenzyme A transport, peroxisomal
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_6735113a_c7d0_4285_b9b4_95b77b795e95
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:33
name: ACADL
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: P28330
constant: false

metaR r1661
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110006#

metaR r2379
type: Reaction
reactant: MODEL1310110006#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaR ADPCOAPTE
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

metaR r1556
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110006#
is described by: ECO:0000000
fast: false

metaM fn2m2masn g
is: CHEBI:32984
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
constant: false
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_9ac1aeb2_bcb2_432b_b1b6_764e02c8217a
initial amount: NaN
name: GCSH
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2653
has only substance units: false
initial concentration: NaN
is: P23434
constant: false

metaR FAOXC183806x
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
reversible: false
type: Reaction
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Beta oxidation of long chain fatty acid
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.3.6

metaR GLUDym
reversible: true
name: glutamate dehydrogenase (NADP), mitochondrial
is version of: http://identifiers.org/ec-code/1.4.1.3
reactant: MODEL1310110006#
is described by: ECO:0000269
kinetic law: MODEL1310110006#
product: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
type: Reaction
fast: false
is: SBO:0000176

metaM nrvnc c
initial amount: NaN
name: nervonate
constant: false
is: CHEBI:32392
is: HMDB02368
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-

http://identifiers.org/biomodels.db/MODEL1310110006#_eb769ea0_6e87_4f4e_bc7f_6eb337aa2857
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q6IBC4
name: NDUFS6
is encoded by: hsa:4726
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

metaM ksii core2 pre7 g
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 7
is: HMDB00175
constant: false
is: SBO:0000247
type: Species
is: C00130
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C67H108N5O51SX CHARGE: -2
is: CHEBI:58053
initial amount: NaN

metaM udpg c
has only substance units: false
is: C00029
initial amount: NaN
is: CHEBI:58367
initial concentration: 1.0
name: UDPglucose
type: Species
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: HMDB00286

metaR r2378
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
type: Reaction
reactant: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
fast: false

metaR r1662
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
fast: false
product: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110006#_1c27ec08_95bc_41c4_b700_b6afbb65a8a0
has only substance units: false
name: CTH
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:1491
initial amount: NaN
type: Species
is: SBO:0000252
is: P32929

metaM tdcoa m
name: Tetradecanoyl-CoA (n-C14:0CoA)
has only substance units: false
is: C02593
is: SBO:0000247
constant: false
is: CHEBI:57385
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: HMDB01521
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false

metaR r1557
kinetic law: MODEL1310110006#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_6c557f0c_9065_42ab_9377_d6370dc8fb03
constant: false
initial amount: NaN
is encoded by: hsa:6241
is: P31350
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
name: RRM2

metaR B3GNT39g
modifier: MODEL1310110006#
product: MODEL1310110006#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
type: Reaction
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
fast: false
reactant: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000

metaR EX tetdec2crn
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

metaR r1428
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reactant: MODEL1310110006#
fast: false
name: Free diffusion
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#

metaR GLYt7 311 r
type: Reaction
is described by: ECO:0000006
reversible: true
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110006#
is: SBO:0000185
modifier: MODEL1310110006#
fast: false

metaR LNLNCACRNt
reversible: false
is: SBO:0000185
reactant: MODEL1310110006#
is described by: ECO:0000269
fast: false
type: Reaction
name: transport into the mitochondria (carnitine)
product: MODEL1310110006#
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR COAtn
kinetic law: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110006#
name: coenzyme A transport, nuclear

metaM nad x
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3305
name: Nicotinamide adenine dinucleotide
is: CHEBI:57540
constant: false
initial amount: NaN
is: HMDB00902
type: Species
is: C00003
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_8218efa4_6280_4aab_9c49_b957f3a4fd5b
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:53947
is: Q9NPC4
is: SBO:0000252
name: A4GALT
initial amount: NaN

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_cf8cf0aa_90b0_4aca_9cac_3b96e232e8f3
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:278
is: SBO:0000252
is: P04745
name: AMY1C
initial amount: NaN
constant: false

metaR S6TASE8ly
is: SBO:0000176
name: N-acetylgalactosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110006#
reversible: true
modifier: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR EX crvnc LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC22:6 exchange
type: Reaction

metaR r1429
reactant: MODEL1310110006#
name: Free diffusion
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:

metaM CE2839 e
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
name: maltodecaose
initial concentration: 1.0
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
is: http://identifiers.org/pubchem.compound/5041
constant: false
initial amount: NaN
is: C01936

metaM nrvnc e
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
initial concentration: 1.0
constant: false
is: HMDB02368
is: CHEBI:32392
name: nervonate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_e5a7f68c_ac68_4a7b_ad03_a77f8a323429
is encoded by: hsa:3284
initial concentration: NaN
type: Species
name: HSD3B2
initial amount: NaN
constant: false
is: P26439
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_b57a5760_9093_4f74_99c1_be81e3e4f327
is: SBO:0000252
type: Species
constant: false
has only substance units: false
is encoded by: hsa:5152
initial amount: NaN
initial concentration: NaN
name: PDE9A
boundary condition: true

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaM m8masn g
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C70H117N2O55X CHARGE: 0
type: Species
constant: false
is: C05876

metaR COAtm
is: SBO:0000185
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
product: MODEL1310110006#
is described by: ECO:0000269
name: CoA transporter
type: Reaction
reversible: true
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only

metaM trdox m
constant: false
is: SBO:0000247
name: Oxidized thioredoxin
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial concentration: 1.0
has only substance units: false
is: CHEBI:18191

http://identifiers.org/biomodels.db/MODEL1310110006#_63ec46f6_f0bc_479c_a04f_976dbdfd20a4
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:7378
name: UPP1
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_460931ff_0d61_4233_b9bd_914771d7a4d1
has only substance units: false
name: MBOAT2
initial amount: NaN
is encoded by: hsa:129642
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q6ZWT7
boundary condition: true
type: Species

metaM dece4coa m
initial amount: NaN
name: 4-decenoylcoa
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB02145
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false
type: Species

metaR r1559
product: MODEL1310110006#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM leu L m
is: HMDB00687
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:15603
name: L-leucine
boundary condition: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
type: Species
initial concentration: 1.0

metaR RE1903R
reactant: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
name: RE1903
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_5e697189_4b69_45fd_aeb1_2b1ae66b44d1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:23057
initial concentration: NaN
initial amount: NaN
name: NMNAT2
type: Species
constant: false
has only substance units: false

metaR r1664
reactant: MODEL1310110006#
type: Reaction
fast: false
kinetic law: MODEL1310110006#
is described by: ECO:0000000
modifier: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
name: Y+LAT2 Utilized transport
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM 56dura c
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00076
is: CHEBI:15901
name: 5,6-dihydrouracil
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_7d0268cf_c48a_423a_b7dd_1809c466cdc4
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:10786
initial concentration: NaN
has only substance units: false
constant: false
name: SLC17A3
is: O00476
initial amount: NaN

metaR DOPASULT
is described by: ECO:0000269
name: Dopamine Sulfotransferase
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.1
is: SBO:0000176
fast: false
product: MODEL1310110006#
reversible: false

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaR r2375
kinetic law: MODEL1310110006#
product: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
reactant: MODEL1310110006#
is: SBO:0000185

metaR PEt
name: phosphatidylethanolamine transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110006#
reversible: true
product: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#

metaR RE2814M
is: SBO:0000176
product: MODEL1310110006#
name: RE2814
reactant: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_85e245cf_21a6_4309_91dd_b20ec5d59123
initial concentration: NaN
name: ADSL
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:158
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_e518155c_2a00_4ddc_bab2_d346d7525098
is: A8K7J7
boundary condition: true
constant: false
is encoded by: hsa:3098
initial amount: NaN
is: SBO:0000252
name: HK1
initial concentration: NaN
type: Species
has only substance units: false

metaM fad e
is: SBO:0000247
initial amount: NaN
is: HMDB01248
is: CHEBI:16238
is: C00016
initial concentration: 1.0
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
boundary condition: false
has only substance units: false
constant: false
name: Flavin adenine dinucleotide oxidized

metaR r1423
product: MODEL1310110006#
name: Facilitated diffusion
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
type: Reaction
kinetic law: MODEL1310110006#
fast: false
is: SBO:0000185

metaR GAL3ST11
name: Galactosylceramide sulfotransferase
notes: GENE_ASSOCIATION: (9514.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.8.2.11 Confidence Level: 4 AUTHORS: PMID:9030544 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.11
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110006#
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_f483c5da_0303_4180_ac48_df138bd15e68
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: SULT1A1
is encoded by: hsa:6817
boundary condition: true
is: SBO:0000252
type: Species

metaR HEXCt
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110006#
is: SBO:0000185
name: fatty acid transport via diffusion
kinetic law: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110006#

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaR BILGLCURtr
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110006#
type: Reaction
name: glucuronidated compound transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
fast: false
product: MODEL1310110006#
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_1442330b_276a_4848_9b5c_394c1adb036f
name: PLCE1
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:51196
initial amount: NaN
has only substance units: false
is: Q9P212
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_47fbeb7a_8990_4232_80af_c576051b8188
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false
name: _AI818585_1_c
is encoded by: hsa:AI818585
is: SBO:0000252

metaM CE0713 m
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
name: 3-oxolinoleoyl-CoA
initial concentration: 1.0
has only substance units: false
is: HMDB02329
is: CHEBI:30623
boundary condition: false

metaR r2374
type: Reaction
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaR SACCD4m
fast: false
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.5.1.8
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.10 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
reversible: false
product: MODEL1310110006#
modifier: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000176
name: saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial
type: Reaction
is described by: ECO:0000269

metaR S6T12g
reversible: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110006#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110006#
type: Reaction

metaM tyr L c
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
name: L-tyrosine
is: HMDB00158
is: CHEBI:17895
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_deed587e_a5c5_48b3_831e_94efaa97567b
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:4882
name: NPR2
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_3ed7b42e_96f6_45f6_ac7e_6d5c77693d81
initial amount: NaN
name: INPPL1
is encoded by: hsa:3636
is: O15357
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_00a17432_4a91_4123_865d_d6fb6cd65797
initial amount: NaN
is: SBO:0000252
is: Q9H008
name: LHPP
has only substance units: false
is encoded by: hsa:64077
constant: false
initial concentration: NaN
type: Species
boundary condition: true

metaR PPNCL3
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.3.2.5
name: phosphopantothenate-cysteine ligase
fast: false
kinetic law: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110006#
is described by: ECO:0000269
modifier: MODEL1310110006#

metaR HISSNAT5tc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_ea95af71_8246_4ef4_a084_80c981744f3b
constant: false
is encoded by: hsa:8813
boundary condition: true
has only substance units: false
initial concentration: NaN
name: DPM1
is: SBO:0000252
is: O60762
initial amount: NaN
type: Species

metaM core6 l
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: Core 6
type: Species
is: HMDB00143
is: CHEBI:12936
boundary condition: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial amount: NaN

metaM ppa c
name: propionate
is: HMDB00237
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:17272
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial amount: NaN

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM thcholstoic m
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: HMDB03873
initial amount: NaN
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:18402
constant: false
boundary condition: false

metaM gd3 hs g
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:28424
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
name: GD3

metaM tetpent3 e
name: tetracosapentaenoic acid, n-3
is: HMDB06323
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
has only substance units: false

metaR PAFt
reactant: MODEL1310110006#
type: Reaction
name: 1-alkyl 2-acteylglycerol 3-phosphocholine transport
is: SBO:0000185
product: MODEL1310110006#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110006#

metaM pail4p hs c
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58178
type: Species
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277

metaM fad c
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB01248
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial concentration: 1.0
has only substance units: false
is: C00016
boundary condition: false
name: Flavin adenine dinucleotide oxidized
type: Species

metaR r0870
modifier: MODEL1310110006#
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.7.72
reversible: true
is: SBO:0000185
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.3.4
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.4.13
name: Facilitated diffusion

metaR r2377
type: Reaction
reactant: MODEL1310110006#
product: MODEL1310110006#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110006#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_51cc99f8_a133_47d9_aed4_887da25f8595
boundary condition: true
has only substance units: false
is: P08236
initial concentration: NaN
is encoded by: hsa:2990
constant: false
type: Species
name: GUSB
initial amount: NaN
is: SBO:0000252

metaR DOLPMT4 Ler
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110006#
fast: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185
reversible: false
type: Reaction

metaM 6dhf e
is: HMDB06563
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
name: hexaglutamyl folate (DHF)
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_f628ceb2_3e6f_4f1d_ad07_6b49394320f3
initial amount: NaN
type: Species
is: Q16836
name: HADH
is encoded by: hsa:3033
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false

metaM biliverd c
type: Species
is: CHEBI:57991
constant: false
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
initial amount: NaN
initial concentration: 1.0
name: biliverdin(2-)
is: HMDB01008
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_914b23f3_2922_4a5f_84b2_cb113679df0c
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:56922
initial amount: NaN
type: Species
has only substance units: false
is: Q96RQ3
boundary condition: true
name: MCCC1

metaR FAOXTC101TC102m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:1-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_89610540_7e43_4551_8f86_836968622ab9
is: Q11201
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
name: ST3GAL1
constant: false
is: SBO:0000252
is encoded by: hsa:6482
initial amount: NaN

metaR r2376
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
fast: false
reactant: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#

metaR r1660
is: SBO:0000185
product: MODEL1310110006#
reversible: true
modifier: MODEL1310110006#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_72fbb824_efb8_4e1a_8e62_a63e36d1fb36
initial concentration: NaN
is: P27338
has only substance units: false
initial amount: NaN
is encoded by: hsa:4129
type: Species
is: SBO:0000252
boundary condition: true
name: MAOB
constant: false

metaM tyr L e
initial amount: NaN
is: HMDB00158
initial concentration: 1.0
constant: false
name: L-tyrosine
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: CHEBI:17895

metaR SBTD D2
is version of: http://identifiers.org/ec-code/1.1.1.14
notes: GENE_ASSOCIATION: (6652.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.14 Confidence Level: 0 AUTHORS: PMID:14965227 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
reversible: false
product: MODEL1310110006#
name: D-sorbitol dehydrogenase (D-fructose producing)
is: SBO:0000176
type: Reaction
reactant: MODEL1310110006#

metaM ppa e
is: CHEBI:17272
name: propionate
type: Species
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00237
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247

metaR 3MOX4HOXPGALDOX NADP
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110006#
fast: false
type: Reaction
modifier: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
is described by: ECO:0000304
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_ce33129c_9c62_45ea_a8ba_5626cf42d88c
initial amount: NaN
name: NDUFA11
is encoded by: hsa:126328
is: C9JT23
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_342bb9a6_d22c_4b9b_9fdd_7df70caba0ea
constant: false
initial amount: NaN
name: SGPP1
initial concentration: NaN
is encoded by: hsa:81537
has only substance units: false
type: Species
is: Q9BX95
boundary condition: true
is: SBO:0000252

metaM dgcholcoa x
is: HMDB06897
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24?,25-,26+,27?,28?,29?,30+,31+,34?,36+,37+,38?,42+,44-,45+/m0/s1 EHMN_ABBREVIATION: C05461
initial amount: NaN
is: SBO:0000247
is: C05461
boundary condition: false
name: Chenodeoxyglycocholoyl-CoA
constant: false
type: Species

metaM mi1p D n
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:58433
is: SBO:0000247
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
is: HMDB02985
constant: false
name: 1D-myo-inositol 1-phosphate(2-)

metaM 4mzym int1 r
is: HMDB06927
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
constant: false
name: 4-Methylzymosterol intermediate 1
type: Species
is: SBO:0000247

metaM 4izp c
initial concentration: 1.0
name: 4-Imidazolone-5-propanoate
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
is: HMDB01014
type: Species
has only substance units: false
is: CHEBI:57255
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR B MANNASEly
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000176
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.25
is described by: ECO:0000000
modifier: MODEL1310110006#
fast: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
name: beta-mannosidase, lysosomal
reversible: false

metaR r0413
type: Reaction
product: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
reversible: false
modifier: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110006#
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40

metaR CERT1gt
fast: false
is: SBO:0000185
modifier: MODEL1310110006#
reactant: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
name: ceramide transport protein
kinetic law: MODEL1310110006#
is described by: ECO:0000304
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110006#_15407824_af31_418f_b656_1df7746784d8
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: NDUFB9
has only substance units: false
type: Species
is: Q9Y6M9
initial concentration: NaN
is encoded by: hsa:4715
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_fc639445_1584_47da_a3bf_95a4f9c21a02
name: B3GALT5
type: Species
has only substance units: false
is encoded by: hsa:10317
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN

metaR INSt
modifier: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
fast: false
kinetic law: MODEL1310110006#
reversible: true
product: MODEL1310110006#
is: SBO:0000185
name: Inosine transport (diffusion)

metaM CE5120 m
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57923
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
type: Species
name: trans-2-cis-8-tetradecadienoyl-CoA

metaR GALASE9ly
type: Reaction
reversible: false
product: MODEL1310110006#
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#

metaM HC01162 c
constant: false
initial amount: NaN
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
type: Species
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
initial concentration: 1.0
is: CHEBI:58376
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_f982e4ac_8651_464c_a0c6_57be46c52916
is: B1AM93
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4702
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: NDUFA8
type: Species

metaM 3ttetddcoa m
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
boundary condition: false
name: 3-hydroxy trans5,8tetradecadienoyl coa
is: HMDB02014
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_853f7913_41d0_4c3e_a8ee_f82ba0640df2
initial concentration: NaN
name: PI4KA
initial amount: NaN
is: B4DYG5
boundary condition: true
is encoded by: hsa:5297
type: Species
constant: false
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_324459ce_43c2_49d1_a9f2_5d47bf43f495
is: Q8NFW8
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: CMAS
is encoded by: hsa:55907
is: SBO:0000252

metaM dcsptn1crn m
has only substance units: false
constant: false
boundary condition: false
type: Species
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB06321

http://identifiers.org/biomodels.db/MODEL1310110006#_d52fc71c_15bc_4bf1_bfaf_89b1c3fdb942
is: SBO:0000252
name: SUOX
is encoded by: hsa:6821
initial concentration: NaN
is: P51687
type: Species
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

metaM hom L c
type: Species
name: L-homoserine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
has only substance units: false
boundary condition: false
is: CHEBI:15699
is: SBO:0000247
initial concentration: 1.0
is: HMDB00719
initial amount: NaN
constant: false

metaM tetpent3 c
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB06323
boundary condition: false
name: tetracosapentaenoic acid, n-3
type: Species

metaM 10fthf m
has only substance units: false
is: HMDB00972
type: Species
name: 10-formyltetrahydrofolate(2-)
is: SBO:0000247
initial amount: NaN
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
constant: false
initial concentration: 1.0

metaM tettet6 e
is: HMDB06246
initial concentration: 1.0
constant: false
type: Species
name: tetracosatetraenoic acid n-6
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+
is: SBO:0000247

metaR RE1520M
modifier: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110006#
name: RE1520
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
is: SBO:0000176
type: Reaction
product: MODEL1310110006#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR MI1345PP
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.3.36
type: Reaction
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
fast: false
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.3.86
kinetic law: MODEL1310110006#
reversible: false
is: SBO:0000176
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.56
is described by: ECO:0000269

metaM thcholstoic c
boundary condition: false
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: HMDB03873
type: Species
is: SBO:0000247
is: CHEBI:18402
constant: false

metaR S6T13g
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
modifier: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
fast: false
product: MODEL1310110006#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaM 2hb e
is: CHEBI:1148
name: 2-Hydroxybutyrate
type: Species
initial concentration: 1.0
is: HMDB00008
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
is: SBO:0000247
initial amount: NaN

metaM g2m8masn r
notes: FORMULA: C82H137N2O65X CHARGE: 0
boundary condition: false
has only substance units: false
is: SBO:0000247
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
is: C05874
constant: false
initial concentration: 1.0
type: Species

metaR PFK
reversible: false
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000304
fast: false
modifier: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
name: phosphofructokinase
is version of: http://identifiers.org/ec-code/2.7.1.11
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110006#_e9a154c6_ec07_41ac_ae9c_53faa9a888ef
type: Species
name: ENPP1
is: P22413
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5167
constant: false

metaR RE3624M
is described by: ECO:0000000
kinetic law: MODEL1310110006#
is: SBO:0000176
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
product: MODEL1310110006#
name: RE3624
reactant: MODEL1310110006#

metaR FAOXTC182TC162m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaR UGALNACtg
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
name: UDP-GalNAc Golgi transport via CMP antiport
modifier: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
reversible: true
is: SBO:0000185
product: MODEL1310110006#
reactant: MODEL1310110006#
fast: false

metaR KHte
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110006#
name: KHte
reversible: true
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110006#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110006#_93861aaa_7b38_4c4d_be6d_5d856ae81917
constant: false
initial concentration: NaN
has only substance units: false
name: _AU149534_1_e
is encoded by: hsa:AU149534
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

metaR C3DCe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

metaR AMACR2p
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/5.1.99.4
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (23600.1) or (23600.2) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 2 AUTHORS: NOTES:should be analogous to AMACRp as per KEGG - in this case: reductase not a racemase NJ
modifier: MODEL1310110006#
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
reversible: false
name: alpha-methylacyl-CoA racemase (reductase)
is: SBO:0000176
type: Reaction

metaM lgt S c
name: (R)-S-lactoylglutathionate(1-)
is: HMDB01066
boundary condition: false
initial amount: NaN
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:57474
initial concentration: 1.0
type: Species

metaR HISTAtu
is: SBO:0000185
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
modifier: MODEL1310110006#
is described by: ECO:0000269
reversible: true
product: MODEL1310110006#
name: Histamine uniport
type: Reaction

metaM orot c
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: CHEBI:30839
name: Orotate
constant: false
is: SBO:0000247
is: HMDB00226
initial amount: NaN
is: C00295
initial concentration: 1.0

metaR RE1897C
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110006#
fast: false
is: SBO:0000176
name: RE1897
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
kinetic law: MODEL1310110006#
product: MODEL1310110006#

metaR FACOAL260
reactant: MODEL1310110006#
is: SBO:0000176
name: fatty-acid--CoA ligase (n-C26:0)
reversible: true
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110006#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:cytoplasmic version -NJ
type: Reaction
kinetic law: MODEL1310110006#

metaM tettet6 c
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
is: HMDB06246
name: tetracosatetraenoic acid n-6
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C24H39O2 CHARGE: -1 INCHI: InChI=1/C24H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h16-23H,2-15H2,1H3,(H,25,26)/b17-16+,19-18+,21-20+,23-22+

metaM pail4p hs n
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial concentration: 1.0
has only substance units: false
is: CHEBI:58178
boundary condition: false
is: SBO:0000247
type: Species
constant: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110006#_b47826e1_e525_4aec_94fb_a75c798e4bed
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: NDUFC2
is encoded by: hsa:4718
constant: false
is: Q549M5
boundary condition: true

metaR GLUPRT
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
type: Reaction
is: SBO:0000176
modifier: MODEL1310110006#
is described by: ECO:0000269
name: glutamine phosphoribosyldiphosphate amidotransferase
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.2.14
reversible: false
product: MODEL1310110006#
fast: false

metaM hom L e
name: L-homoserine
has only substance units: false
is: SBO:0000247
is: HMDB00719
is: CHEBI:15699
boundary condition: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial concentration: 1.0

metaR NDPK2n
reversible: true
kinetic law: MODEL1310110006#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reactant: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
product: MODEL1310110006#
type: Reaction

metaM 2hb c
is: CHEBI:1148
initial amount: NaN
is: HMDB00008
name: 2-Hydroxybutyrate
boundary condition: false
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR URIDK2m
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
fast: false
is: SBO:0000176
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
reversible: true
is described by: ECO:0000134
name: uridylate kinase (dUMP), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110006#_5264a33d_e0db_43b9_8000_058af917bc8e
initial amount: NaN
is encoded by: hsa:9517
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is: O15270
name: SPTLC2
type: Species
boundary condition: true

metaM trdox c
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:18191
name: Oxidized thioredoxin
type: Species
is: SBO:0000247
is: C00343
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_72894eb8_03df_48c5_8c72_fa958d5b925b
boundary condition: true
name: _AI222095_1_e
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:AI222095
initial amount: NaN
initial concentration: NaN
constant: false

metaR ABO6g
is version of: http://identifiers.org/ec-code/2.4.1.37
reactant: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
type: Reaction
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
kinetic law: MODEL1310110006#
product: MODEL1310110006#
fast: false
modifier: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000269

metaR ARACHCPT2
reversible: false
product: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
name: carnitine transferase
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false

metaM HC00822 l
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
name: Chitobiose
is: SBO:0000247
has only substance units: false
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
boundary condition: false
is: CHEBI:28681

metaR SPHS1Ptr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110006#
product: MODEL1310110006#
name: sphingosine-1-phosphate transport
reactant: MODEL1310110006#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_090a7d51_8d0c_439e_83b2_f2e9b44e54a1
is: SBO:0000252
is encoded by: hsa:6532
name: SLC6A4
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P31645
type: Species

metaR S6T7g
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110006#
is described by: ECO:0000000
type: Reaction

metaM orn c
type: Species
name: Ornithine
initial amount: NaN
is: C01602
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00214
boundary condition: false
is: SBO:0000247
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110006#_4798f752_926e_4dbf_9cff_da8322db141d
name: AHCYL1
is encoded by: hsa:10768
is: O43865
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM dc2coa m
constant: false
type: Species
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
initial concentration: 1.0
boundary condition: false
name: trans-Dec-2-enoyl-CoA
has only substance units: false
is: SBO:0000247
is: CHEBI:61406
initial amount: NaN

metaR DGSNt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
name: deoyguanosine transport via diffusion
product: MODEL1310110006#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110006#_c4831633_97e1_4c53_b20b_19f47121440d
name: GALNT10
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q86SR1
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:55568

metaM orot e
is: SBO:0000247
type: Species
name: orotate
initial concentration: 1.0
is: HMDB00226
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: CHEBI:30839
constant: false
boundary condition: false

metaR r0410
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
fast: false
kinetic law: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19

metaR PROt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
name: L-proline reversible transport via proton symport
kinetic law: MODEL1310110006#
product: MODEL1310110006#
fast: false
is: SBO:0000185
modifier: MODEL1310110006#
is described by: ECO:0000304
reactant: MODEL1310110006#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110006#_a9020d62_664e_4e80_8b43_483dec99216e
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
name: MGAT2
is encoded by: hsa:4247
constant: false
boundary condition: true
is: Q10469

metaM em2emgacpail hs r
type: Species
is: HMDB03125
has only substance units: false
is: CHEBI:16240
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_b7e8b7aa_8bdc_41aa_9c21_3df9b7e92746
is: SBO:0000252
constant: false
is encoded by: hsa:1632
name: ECI1
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P42126
boundary condition: true
type: Species

metaR DURItn
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
fast: false
name: deoxyuridine transport in nucleus
product: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110006#_f6df0bd3_64d7_4c88_a86c_82ff0583a799
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q9UBQ7
name: GRHPR
is encoded by: hsa:9380
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_7555eb6d_f668_49ca_a8d4_b7b3dd5195f6
type: Species
is: SBO:0000252
name: GGT1
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:2678
is: P19440
constant: false

metaR MANtg
reactant: MODEL1310110006#
name: mannose efflux from Golgi apparatus
is: SBO:0000185
kinetic law: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reversible: false
product: MODEL1310110006#

metaR EX 3hdececrn
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecenoyl carnitine
type: Reaction

metaM 2maacoa m
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: 2-methylacetoacetyl-CoA(4-)
type: Species
is: HMDB01157
boundary condition: false
is: SBO:0000247
is: CHEBI:57335
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
constant: false

metaR HAtly
kinetic law: MODEL1310110006#
fast: false
name: hyaluronan transport, extracellular to lysosome
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110006#

metaM l2n2m2mn l
notes: FORMULA: C54H91N3O41 CHARGE: 0
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:12936
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
type: Species
boundary condition: false

metaR TIGCRNe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaR r0186
type: Reaction
modifier: MODEL1310110006#
product: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2

metaM 6dhf l
has only substance units: false
initial amount: NaN
name: hexaglutamyl folate (DHF)
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06563
constant: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1

metaM pail5p hs c
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:57795
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
constant: false

metaM gal14acglcgalgluside hs g
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
name: Lactoneotetraosylceramide
initial concentration: 1.0
is: CHEBI:17103
type: Species
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_bb4a6e06_f21d_4833_8800_d441d10b0d6e
constant: false
type: Species
is encoded by: hsa:482
has only substance units: false
initial concentration: NaN
boundary condition: true
has part: P14415
name: ATP1A3:ATP1B2
is: SBO:0000297
initial amount: NaN

metaM cholcoar x
has only substance units: false
initial concentration: 1.0
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
boundary condition: false
constant: false
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
is: HMDB02178
is: SBO:0000247
is: CHEBI:58677
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_8b61ca8c_c76c_471b_85b5_a593bd1d7d31
has only substance units: false
is: SBO:0000297
is encoded by: hsa:5160
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has part: P08559
name: DLAT:DLD:PDHA1:PDHB:PDHX
initial amount: NaN

metaM 6dhf m
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
constant: false
initial concentration: 1.0
name: hexaglutamyl folate (DHF)
has only substance units: false
is: HMDB06563

http://identifiers.org/biomodels.db/MODEL1310110006#_fa8c9050_5c80_4202_b95a_24631504cdc3
is: P32019
constant: false
is encoded by: hsa:3633
is: SBO:0000252
boundary condition: true
name: INPP5B
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_6783844d_3805_4077_bdcd_fc9d3f640016
initial concentration: NaN
name: NME1:NME2
constant: false
initial amount: NaN
is encoded by: hsa:4830
is: SBO:0000297
type: Species
has only substance units: false
boundary condition: true

metaM HC01118 r
is: CHEBI:57310
is: SBO:0000247
name: presqualene diphosphate(3-)
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
initial concentration: 1.0
has only substance units: false
constant: false

metaR ARACHCPT1
product: MODEL1310110006#
reactant: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110006#
fast: false
name: carnitine transferase
reversible: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

metaM ksi pre2 g
is: HMDB00175
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C00130
name: keratan sulfate I biosynthesis, precursor 2
type: Species
notes: FORMULA: C87H142N6O62X CHARGE: -1
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110006#_eefa7e56_1d9a_45f8_bdd4_14859e5cb0e8
name: HSD3B7
is: Q9H2F3
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:80270

metaM HC01407 m
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:28276
has only substance units: false
constant: false
name: (S)-Hydroxyhexanoyl-CoA
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_9e2e86fb_35fa_46a1_a95d_f09907ec5df2
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM 3ttetddcoacrn c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C21H37NO5 CHARGE: 0
is: HMDB02014
has only substance units: false
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
initial amount: NaN
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_cd1b9781_28c6_430f_b486_a0d983521160
boundary condition: true
is encoded by: hsa:9162
initial amount: NaN
is: O75912
type: Species
initial concentration: NaN
is: SBO:0000252
name: DGKI
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_a1a5ee94_571e_46a3_abe8_f232a44143e5
type: Species
is encoded by: hsa:4725
boundary condition: true
is: SBO:0000252
name: NDUFS5
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: Q6IBA0

metaM hs deg16 l
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
is: HMDB02704
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:21338
name: heparan sulfate, degradation product 16

http://identifiers.org/biomodels.db/MODEL1310110006#_537d42a1_961a_4861_b5f6_bc59a9dab2b7
boundary condition: true
constant: false
is encoded by: hsa:54363
is: SBO:0000252
name: HAO1
is: Q9UJM8
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_f5d9ec7e_7c2e_4681_ab6d_9f1c7d9f7297
is: F5H2Y9
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: ALDH1A2
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:8854

metaM 2mbcoa m
initial concentration: 1.0
is: CHEBI:57336
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
has only substance units: false
initial amount: NaN
is: HMDB01041
name: 2-methylbutanoyl-CoA(4-)
is: SBO:0000247
type: Species
constant: false
boundary condition: false

metaR HACD1m
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is described by: ECO:0000134
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110006#
modifier: MODEL1310110006#
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
type: Reaction
kinetic law: MODEL1310110006#

metaR r0181
fast: false
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110006#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_2c0dccce_6017_46ba_a2a9_ee595482f228
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
name: ALDOC
initial amount: NaN
is: P09972
is encoded by: hsa:230
constant: false

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM maltpt e
boundary condition: false
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/5141
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: C02052
name: maltopentaose
is: HMDB01296

metaR r0295
reversible: false
kinetic law: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
type: Reaction
product: MODEL1310110006#

metaM orn e
name: Ornithine
type: Species
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: CHEBI:0
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: C01602
is: HMDB00214
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_d9a7a64f_1fb2_4de7_b7f4_3ea4e278bcba
name: NNT
has only substance units: false
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:23530
initial concentration: NaN
is: Q13423
boundary condition: true

metaM 3ttetddcoacrn e
initial concentration: 1.0
is: HMDB02014
boundary condition: false
notes: FORMULA: C21H37NO5 CHARGE: 0
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_a247a438_4fb2_4b72_a16b_589f50d9e4bd
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: _AA614647_1_c
type: Species
is encoded by: hsa:AA614647
initial concentration: NaN
has only substance units: false
constant: false

metaM CE2838 e
is: C01936
is: http://identifiers.org/pubchem.compound/5041
constant: false
initial amount: NaN
has only substance units: false
name: maltononaose
type: Species
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR RE1342C
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
kinetic law: MODEL1310110006#
is: SBO:0000176
reactant: MODEL1310110006#
reversible: true
type: Reaction
product: MODEL1310110006#
name: RE1342

metaR SUBERCROT
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_34c9d86a_2e28_4996_81e0_1ef4521af841
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:5293
type: Species
is: A7E2E0
name: PIK3CD
has only substance units: false
is: SBO:0000252

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaM co e
is: HMDB01361
has only substance units: false
constant: false
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: carbon monoxide
is: CHEBI:17245
type: Species
initial concentration: 1.0

metaM bamppald c
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7975
initial concentration: 1.0
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
type: Species
is: C05665
boundary condition: false
name: beta-Aminopropion aldehyde
is: HMDB01106

metaR AMETt2m
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
type: Reaction
reversible: true
kinetic law: MODEL1310110006#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
is described by: ECO:0000269
reactant: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#

metaM dcsptn1crn c
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl carnitine
type: Species
initial concentration: 1.0
is: HMDB06321
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+

metaR C12OHc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

metaM 10fthf e
type: Species
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: HMDB00972
is: CHEBI:57454
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
name: 10-formyltetrahydrofolate(2-)
is: SBO:0000247

metaR SPHS1Pte
is described by: ECO:0000000
type: Reaction
name: sphingosine-1-phosphate transport
fast: false
is: SBO:0000185
reactant: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
reversible: true
kinetic law: MODEL1310110006#

metaM co c
has only substance units: false
is: HMDB01361
initial amount: NaN
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
constant: false
is: SBO:0000247
is: CHEBI:17245
name: carbon monoxide
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_21ad9f28_4f10_429a_a98f_f92ac36e8e70
constant: false
boundary condition: true
is: P00338
initial concentration: NaN
name: LDHA
is encoded by: hsa:3939
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN

metaR NADS2
is: SBO:0000176
name: NAD synthase (glutamine-hydrolysing)
modifier: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
fast: false
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.3.5.1
is described by: ECO:0000269

metaR ACNAMlt
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
type: Reaction
name: N-acetylneuraminate transport into lysososme
fast: false
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110006#
product: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000185
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_a8fee448_dc46_4b10_b8c4_1b441e579921
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10165
type: Species
is: Q9UJS0
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
name: SLC25A13

metaR C141OHe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:1-OH
type: Reaction

metaR SARCStex
is: SBO:0000185
name: Sarcosine transport (extracellular to cytosol)
is described by: ECO:0000000
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES:MM
reversible: false
fast: false
kinetic law: MODEL1310110006#
type: Reaction

metaM 13 cis retn c
is: D00348
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
type: Species
is: HMDB06219
name: 13-cis-retinoate
boundary condition: false
is: http://identifiers.org/pubchem.compound/7847414

http://identifiers.org/biomodels.db/MODEL1310110006#_de8d4802_8b5c_470c_a157_fd7fa8b2a6e0
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: O14975
is encoded by: hsa:11001
boundary condition: true
initial amount: NaN
name: SLC27A2
constant: false
type: Species

metaM crvnc c
name: cervonic acid, C22:6 n-3
is: CHEBI:36005
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C22H31O2 CHARGE: -1
is: HMDB02183

http://identifiers.org/biomodels.db/MODEL1310110006#_c8051586_1733_4f67_8ffb_f9049e74ca9b
type: Species
boundary condition: true
has only substance units: false
name: SLC29A1
is encoded by: hsa:2030
initial amount: NaN
constant: false
is: Q99808
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_08cfed68_333f_4fd8_b8da_ff785e1e7a5e
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:6484
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ST3GAL4
constant: false
is: Q6IBE6

metaM cs a deg3 l
notes: FORMULA: C31H48NO32S2 CHARGE: -3
constant: false
type: Species
is: HMDB00127
is: CHEBI:15748
initial amount: NaN
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 3
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaM 3deccrn c
name: 3-hydroxydecanoylcarnitine
initial amount: NaN
notes: FORMULA: C17H33NO5 CHARGE: 0
constant: false
is: HMDB13325
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_129be0be_c434_4554_a02d_d08fade43b6b
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:2356
is: Q05932
has only substance units: false
constant: false
name: FPGS
initial concentration: NaN

metaR ACNACNGALGBSIDEtg
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110006#
type: Reaction
fast: false
reactant: MODEL1310110006#
name: acnacngalgbside hs intracellular transport
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ

metaM HC00822 e
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
name: Chitobiose
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
boundary condition: false
has only substance units: false
is: CHEBI:28681

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR AG13T8g
type: Reaction
reversible: false
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_07ff18f4_1b80_46cf_9f62_5f3a9fe09607
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:205
boundary condition: true
initial concentration: NaN
name: AK4

metaM 10fthf c
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: C00234
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-Formyltetrahydrofolate
has only substance units: false
is: HMDB00972
is: CHEBI:57454
is: SBO:0000247

metaR RE3002X
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
fast: false
type: Reaction
name: RE3002
product: MODEL1310110006#
modifier: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

metaR UMPK2n
kinetic law: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
type: Reaction
name: UMP kinase (CTP),nuclear
product: MODEL1310110006#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_112c3ddd_4be1_4d9d_b262_a80a054624eb
constant: false
name: _AA629629_1_m
is encoded by: hsa:AA629629
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR C141OHc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecenoyl carnitine
type: Reaction

metaR TETTET6t
is described by: ECO:0000000
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110006#
fast: false
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000185
reactant: MODEL1310110006#
reversible: true

metaR RTOTALt
reactant: MODEL1310110006#
is described by: ECO:0000000
name: RTOTAL transport
kinetic law: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110006#

metaR EHGLAT2m
reactant: MODEL1310110006#
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110006#
is described by: ECO:0000304
product: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial

metaM adn c
is: CHEBI:16335
name: Adenosine
has only substance units: false
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: HMDB00050
initial amount: NaN
initial concentration: 1.0
is: C00212
is: SBO:0000247
boundary condition: false
type: Species

metaR SUCCACT
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaM adn e
boundary condition: false
has only substance units: false
is: HMDB00050
name: Adenosine
initial concentration: 1.0
is: CHEBI:16335
is: C00212
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
is: SBO:0000247
type: Species
constant: false

metaM glyc R m
is: HMDB00139
type: Species
name: D-glycerate
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:16659
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_cb1fb9ad_05a6_44aa_8027_51c0db62b68a
initial amount: NaN
has only substance units: false
name: PKM2
initial concentration: NaN
is: B4DNK4
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:5315

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_e4342590_6b4b_4b6d_b91f_673a1713c912
initial amount: NaN
type: Species
is encoded by: hsa:4122
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q9P1E4
name: MAN2A2
boundary condition: true

metaM core4 g
constant: false
has only substance units: false
is: CHEBI:16478
type: Species
name: Core 4
boundary condition: false
notes: FORMULA: C24H40N3O15X CHARGE: 0
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM arachd r
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
name: arachidonate
initial amount: NaN
constant: false
boundary condition: false
is: HMDB01043
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:32395
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_2e3b0f8e_fa3c_4055_a13d_ce7a1c91800d
initial concentration: NaN
name: BAAT
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:570
is: Q14032
constant: false

metaR PCHOLPm hs
name: choline phosphatase
is version of: http://identifiers.org/ec-code/3.1.4.4
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
is: SBO:0000176
is described by: ECO:0000269
reversible: false
fast: false
product: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
modifier: MODEL1310110006#

metaM crvnc e
is: SBO:0000247
is: CHEBI:36005
type: Species
name: cervonic acid, C22:6 n-3
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: HMDB02183
initial concentration: 1.0
notes: FORMULA: C22H31O2 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110006#_5ef29b76_9b4d_433b_910d_d48788646a69
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1892
initial amount: NaN
boundary condition: true
name: ECHS1
constant: false
type: Species
is: P30084

metaR GK1
is described by: ECO:0000269
name: guanylate kinase (GMP:ATP)
is: SBO:0000176
reactant: MODEL1310110006#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.4.8
kinetic law: MODEL1310110006#

metaR FAOXC201C181x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaR LGNCCOAtx
name: fatty acid intracellular transport
reactant: MODEL1310110006#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

metaM 3deccrn e
initial amount: NaN
constant: false
name: 3-hydroxydecanoylcarnitine
notes: FORMULA: C17H33NO5 CHARGE: 0
is: C02838
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00791
initial concentration: 1.0

metaR ACNACNGALGBSIDEte
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110006#
name: acnacngalgbside hs transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ

metaM 2ddecdicoa x
is: C05279
name: 2,6-dodecadienoylcoa
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB11123
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110006#_f39033e9_2c6b_4daa_ad9d_6f31c1550dd1
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:33
constant: false
name: ACADL
is: P28330

http://identifiers.org/biomodels.db/MODEL1310110006#_5f6c819f_f6a9_49b2_af90_51e820047d26
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:8867
is: O43426
name: SYNJ1

metaR TYRTA
reactant: MODEL1310110006#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: true
is: SBO:0000176
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
fast: false
type: Reaction
name: tyrosine transaminase
kinetic law: MODEL1310110006#
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_5d4dae58_004b_45ab_bb63_2662412c9935
initial amount: NaN
constant: false
boundary condition: true
is: B1AK53
type: Species
has only substance units: false
name: ESPN
is: SBO:0000252
is encoded by: hsa:83715
initial concentration: NaN

metaM dc2coa x
is: HMDB01168
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: trans-Dec-2-enoyl-CoA
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110006#_09c26180_7b15_4266_b92e_10ef0421daf6
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: PDE7A
initial concentration: NaN
type: Species
is encoded by: hsa:5150
is: SBO:0000252

metaM adpcoa c
is: SBO:0000247
initial amount: NaN
is: C14143
initial concentration: 1.0
has only substance units: false
is: HMDB04047
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
type: Species
boundary condition: false
name: adipoylcoa
constant: false

metaR EX decdicrn
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_022037e4_c910_4a6a_ad8b_32f344b51591
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6389
name: SDHA
constant: false
is: P31040
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_fd907c51_13d3_4c6c_8aff_b354f1be8132
constant: false
is encoded by: hsa:3141
is: P50747
initial amount: NaN
name: HLCS
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

metaR MECOAS1m
fast: false
name: mesaconate--CoA ligase (GDP-forming)
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
reactant: MODEL1310110006#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true

metaR RE1573M
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110006#
name: RE1573
kinetic law: MODEL1310110006#
fast: false
reversible: true
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/5.3.3.8

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_87dc6229_9e4e_438f_b6ea_7658f15299f5
has only substance units: false
is: SBO:0000252
constant: false
is: P23378
type: Species
initial amount: NaN
is encoded by: hsa:2731
boundary condition: true
initial concentration: NaN
name: GLDC

http://identifiers.org/biomodels.db/MODEL1310110006#_24b589a9_43c9_485b_a930_277270dcb5ad
has only substance units: false
is: Q92536
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:9057
initial amount: NaN
name: SLC7A6
boundary condition: true

metaR 3SALAASPm
fast: false
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#
modifier: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
reversible: true
is: SBO:0000185
is described by: ECO:0000304
name: cysteinesulfinate-aspartate mitochondrial shuttle

metaR CORE3GTg
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
product: MODEL1310110006#
reactant: MODEL1310110006#
modifier: MODEL1310110006#

metaM adp x
name: ADP(3-)
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB01341

http://identifiers.org/biomodels.db/MODEL1310110006#_5e20b11b_9176_41de_8c0e_c1f0bbfefa9b
name: HK3
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3101
initial amount: NaN
boundary condition: true
is: P52790

metaR AG13T10g
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
is described by: ECO:0000000
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110006#
product: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110006#

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaM lnlccoa c
boundary condition: false
name: linoleic coenzyme A
is: http://identifiers.org/pubchem.compound/5462164
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
is: HMDB01064
type: Species

metaM dhor S c
is: HMDB03349
boundary condition: false
notes: FORMULA: C5H5N2O4 CHARGE: -1 INCHI: InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00285
name: (S)-dihydroorotate
initial amount: NaN
is: SBO:0000247
is: CHEBI:30864
initial concentration: 1.0
type: Species
constant: false
has only substance units: false

metaM for r
initial concentration: 1.0
is: CHEBI:15740
constant: false
boundary condition: false
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
has only substance units: false
name: Formate
is: C00058
is: HMDB00142
is: SBO:0000247
initial amount: NaN
type: Species

metaM btn m
is: SBO:0000247
boundary condition: false
is: HMDB00030
initial concentration: 1.0
name: biotinate
is: CHEBI:57586
constant: false
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120

metaR r1659
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
fast: false
is: SBO:0000185
reversible: true

metaR EX tdcrn
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

metaM lneldccrn c
is: HMDB06461
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
name: Linoelaidyl carnitine
boundary condition: false

metaM adpcoa x
is: C14143
constant: false
is: HMDB04047
name: adipoylcoa
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR ADRNCRNt
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110006#
type: Reaction
name: transport into the mitochondria (carnitine)
is: SBO:0000185
reactant: MODEL1310110006#
fast: false
product: MODEL1310110006#
is described by: ECO:0000000
reversible: false

metaR r2385
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
reversible: false
product: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110006#

metaR FAOXC225C204m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaR ABUTt2r
is: SBO:0000185
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
reversible: true
modifier: MODEL1310110006#
product: MODEL1310110006#
name: 4-aminobutyrate reversible transport in via proton symport
fast: false
reactant: MODEL1310110006#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110006#_fc58fe43_6087_4e38_82d8_1ca1141e6b65
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:MBOAT5
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
name: _MBOAT5_1_c

http://identifiers.org/biomodels.db/MODEL1310110006#_eccb1ede_63a6_4f7e_876f_450f34c513f7
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:29922
is: Q9Y5B8
is: SBO:0000252
initial amount: NaN
name: NME7

metaR HAS1
name: hyaluronan synthase
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.212
modifier: MODEL1310110006#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD

metaM phaccoa c
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57390
type: Species
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
initial amount: NaN
name: phenylacetyl-CoA(4-)
is: HMDB06503

http://identifiers.org/biomodels.db/MODEL1310110006#_b85fae8e_e423_4efc_9d21_0aeb1ef9f4d4
is encoded by: hsa:6470
name: SHMT1
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: P34896
constant: false
initial amount: NaN
is: SBO:0000252

metaR S4TASE5ly
type: Reaction
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.6.12
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: N-acetylgalactosamine-4-sulfatase, lysosomal
reversible: true
reactant: MODEL1310110006#
modifier: MODEL1310110006#

metaR DTMPKm
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110006#
name: dTMP kinase in mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: Confidence Level: 4 AUTHORS: PMID: 17403938 NOTES:
product: MODEL1310110006#
is: SBO:0000176
reactant: MODEL1310110006#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_157b18ff_381f_4b58_8b08_faa11649d7c6
is encoded by: hsa:80339
initial amount: NaN
constant: false
is: Q9NST1
boundary condition: true
is: SBO:0000252
name: PNPLA3
type: Species
initial concentration: NaN
has only substance units: false

metaR PTDCAt
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
fast: false
reactant: MODEL1310110006#
reversible: true
type: Reaction
is described by: ECO:0000000
name: fatty acid transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110006#

metaR DM T antigen g
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR CSNATr
kinetic law: MODEL1310110006#
is: SBO:0000176
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
reactant: MODEL1310110006#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
name: carnitine O-acetyltransferase

http://identifiers.org/biomodels.db/MODEL1310110006#_123e0121_5ab9_4130_b03b_ffdfd4dafc7f
is encoded by: hsa:55163
initial concentration: NaN
constant: false
name: PNPO
is: Q9NVS9
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species

metaR r0990
name: Postulated transport reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
type: Reaction
reversible: true
product: MODEL1310110006#
is: SBO:0000185
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false

metaM HC01231 m
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: SBO:0000247
is: CHEBI:58480

metaR r2384
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110006#
is: SBO:0000185
modifier: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
kinetic law: MODEL1310110006#
reversible: false

metaM ppcoa c
is: CHEBI:57392
constant: false
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
name: Propanoyl-CoA
is: C00100
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01275
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_25901b68_8932_4962_86bb_21a9a243814d
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9BVK2
is encoded by: hsa:79053
boundary condition: true
has only substance units: false
name: ALG8

metaR FPGS4m
product: MODEL1310110006#
name: folylpolyglutamate synthetase (DHF), mitochondrial
modifier: MODEL1310110006#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
reversible: false
is version of: http://identifiers.org/ec-code/6.3.2.17
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

metaM pro D c
is: CHEBI:16313
is: HMDB03411
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
name: D-proline
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1

metaM coa n
is: CHEBI:57287
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
name: coenzyme A(4-)
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
constant: false
is: HMDB01423

metaM 4hexdtetcoa m
initial concentration: 1.0
is: HMDB02288
constant: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
name: 4,7,10,13-hexadecatetraenoylcoa
type: Species
has only substance units: false
initial amount: NaN

metaM 2docopencoa x
is: SBO:0000247
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
name: 2,7,10,13,16-docosapentenoylcoa
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4

metaM vacc c
is: C08367
is: CHEBI:30828
is: SBO:0000247
has only substance units: false
name: trans-vaccenate
type: Species
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+

metaM ditp n
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB03537
name: dITP(4-)
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
type: Species
is: CHEBI:61382

http://identifiers.org/biomodels.db/MODEL1310110006#_1bac864c_c9d8_4350_bbdd_b405c22d6516
is encoded by: hsa:2618
name: GART
is: SBO:0000252
boundary condition: true
is: P22102
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR r1657
modifier: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_b5db5eaf_d947_4d15_9c88_1316fbd7e0af
initial amount: NaN
name: ALG3
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q92685
constant: false
type: Species
is encoded by: hsa:10195
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_6e431053_d2f4_4bdc_b20b_02af7292d0b6
has part: B7Z2T0
type: Species
initial concentration: NaN
name: ATP1A3:ATP1B1
initial amount: NaN
has only substance units: false
is encoded by: hsa:481
boundary condition: true
is: SBO:0000297
has part: A3KLL5
constant: false
is encoded by: hsa:478

http://identifiers.org/biomodels.db/MODEL1310110006#_cab4b7e0_0499_434f_ac6a_6ced7e33a760
is encoded by: hsa:27068
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: PPA2

metaM coa m
is: C00010
name: Coenzyme A
is: HMDB01423
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
type: Species
is: SBO:0000247

metaR 3SALATAim
reversible: false
reactant: MODEL1310110006#
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
product: MODEL1310110006#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
is described by: ECO:0000304

metaR CSNATp
modifier: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000304
is: SBO:0000176
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
reversible: true
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.7
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
fast: false

metaR r1931
fast: false
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000185
name: Y+LAT2 Utilized transport
reversible: false
product: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110006#

metaR r1658
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110006#
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110006#
product: MODEL1310110006#

metaR r2382
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false
product: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
is described by: ECO:0000000

metaR HAS2
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.212
reversible: false
type: Reaction
product: MODEL1310110006#
modifier: MODEL1310110006#
name: hyaluronan synthase
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
fast: false
reactant: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000269

metaR r0051
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.3.5

metaR DURIPP
is version of: http://identifiers.org/ec-code/2.4.2.3
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
reversible: true
kinetic law: MODEL1310110006#
name: deoxyuridine phosphorylase
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
reactant: MODEL1310110006#

metaR FAOXC16180m
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110006#
fast: false
product: MODEL1310110006#
type: Reaction
name: Beta oxidation fatty acid
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110006#
is described by: ECO:0000269

metaR IDOAASE1ly
name: alpha-L-iduronidase, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.76
is: SBO:0000176
product: MODEL1310110006#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110006#_7b211936_f1f7_4308_a8aa_0ba980924ab6
initial amount: NaN
is encoded by: hsa:18
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: ABAT
constant: false
boundary condition: true

metaM vacc e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
is: CHEBI:30828
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: trans-vaccenate

metaM pro D e
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
name: D-proline
initial amount: NaN
boundary condition: false
is: HMDB03411
type: Species
is: SBO:0000247
is: CHEBI:16313
initial concentration: 1.0
constant: false
has only substance units: false

metaM 2decdicoa m
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
type: Species
name: 2,7-decadienoylcoa
constant: false
is: http://identifiers.org/pubchem.compound/16019966

metaM 3thexddcoa m
type: Species
is: SBO:0000247
is: HMDB02014
boundary condition: false
has only substance units: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
constant: false
name: 3-hydroxy trans7,10-hexadecadienoylcoa
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_16c4c8e4_9b30_4c72_94f3_5836917e2f0e
boundary condition: true
type: Species
is: A8K761
has only substance units: false
is: SBO:0000252
name: NDUFB10
constant: false
initial concentration: NaN
is encoded by: hsa:4716
initial amount: NaN

metaM HC02205 c
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
has only substance units: false
constant: false
is: CHEBI:28099
is: SBO:0000247
name: prostaglandin-b2
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaM hexde7coa x
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: 7-hexadecenoylcoa
is: HMDB02288
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_61672092_655f_4ae3_b78d_0a5822cd1c6d
is encoded by: hsa:762
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: CA4
initial amount: NaN
boundary condition: true
type: Species
is: Q6FHI7

metaM 3hexdcrn e
constant: false
initial concentration: 1.0
type: Species
name: 3-hydroxyhexadecanoylcarnitine
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C23H45NO5 CHARGE: 0
is: HMDB13336
boundary condition: false

metaR EX ptdca LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentadecanoate exchange
type: Reaction

metaR RE0383C
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: RE0383
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
modifier: MODEL1310110006#
reversible: true

metaR r1655
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110006#
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110006#

metaM tddedi2coa m
is: HMDB00792
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: C08277
initial concentration: 1.0
name: trans2,6dodecadienoylcoa
has only substance units: false
initial amount: NaN

metaR ACOAD10m
modifier: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110006#
reversible: false
product: MODEL1310110006#
type: Reaction
is described by: ECO:0000269
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
is: SBO:0000176
reactant: MODEL1310110006#

metaM sT antigen g
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C25H40N2O18X CHARGE: -1
name: sialyl-T antigen
is: CHEBI:16565
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN

metaM m4mpdol L c
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
has only substance units: false
type: Species
is: CHEBI:37633
boundary condition: false

metaR r0994
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110006#
fast: false
name: Facilitated diffusion
type: Reaction
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_f1e2d729_dd5b_4c82_b9d7_aa1f75aa6bef
is encoded by: hsa:5151
initial amount: NaN
is: O60658
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
name: PDE8A

http://identifiers.org/biomodels.db/MODEL1310110006#_f1b9a372_5e1e_45c2_88cf_bee7a4347fa2
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: AOC2
initial concentration: NaN
constant: false
is encoded by: hsa:314
has only substance units: false
type: Species

metaR r2380
reversible: true
kinetic law: MODEL1310110006#
product: MODEL1310110006#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
reactant: MODEL1310110006#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110006#_41ace45e_ec59_4248_b590_a9083b254429
initial concentration: NaN
name: PIGO
initial amount: NaN
has only substance units: false
is encoded by: hsa:84720
constant: false
boundary condition: true
is: SBO:0000252
type: Species

metaR r1656
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110006#
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR r1829
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110006#
is described by: ECO:0000000
fast: false
product: MODEL1310110006#

metaM pydx5p c
is: CHEBI:597326
initial amount: NaN
type: Species
boundary condition: false
is: HMDB01491
initial concentration: 1.0
constant: false
name: Pyridoxal 5'-phosphate
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
is: C00018
has only substance units: false
is: SBO:0000247

metaM man1p c
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
is: HMDB06330
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:35374
boundary condition: false
name: D-Mannose 1-phosphate

metaM coa r
has only substance units: false
constant: false
is: CHEBI:57287
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
is: HMDB01423
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C00010

metaM glcur r
boundary condition: false
is: HMDB00127
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: CHEBI:15748
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate

http://identifiers.org/biomodels.db/MODEL1310110006#_5b244c18_2bc9_4588_906a_2a46bad75524
initial concentration: NaN
is: F8VQS7
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:55967
name: NDUFA12
initial amount: NaN

metaM 3hexdcrn c
initial concentration: 1.0
name: 3-hydroxyhexadecanoylcarnitine
constant: false
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C23H45NO5 CHARGE: 0
is: SBO:0000247
boundary condition: false
is: HMDB13336

metaM HC02205 e
boundary condition: false
constant: false
name: prostaglandin-b2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:28099
type: Species
initial concentration: 1.0

metaR 7DHFtl
reactant: MODEL1310110006#
type: Reaction
is: SBO:0000185
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:carrier-mediated transport - but which and how is unknown IT
kinetic law: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
name: 7-glutamyl-DHF transport, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110006#_18d4ed3e_2606_4345_aebf_ca572f22a118
has only substance units: false
constant: false
is encoded by: hsa:160287
type: Species
is: SBO:0000252
name: LDHAL6A
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q6ZMR3

http://identifiers.org/biomodels.db/MODEL1310110006#_b521388b_b3ee_4048_bef8_32f44d10be53
name: _AI935189_1_m
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:AI935189
type: Species

metaR r1540
type: Reaction
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185
reactant: MODEL1310110006#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is described by: ECO:0000000
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
reversible: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110006#_a590e952_0026_4295_9deb_8bc7a71bf9b5
is: SBO:0000297
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4830
constant: false
has part: P22392
is encoded by: hsa:4831
has part: P15531
initial amount: NaN
type: Species
name: NME1:NME2

metaM c8dc c
is: C02838
has only substance units: false
initial amount: NaN
name: suberyl carnitine
type: Species
boundary condition: false
notes: FORMULA: C15H26NO6 CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
is: HMDB00791
constant: false

metaR r1653
reactant: MODEL1310110006#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110006#
product: MODEL1310110006#

metaM lnlc r
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
initial concentration: 1.0
name: linoleate
is: CHEBI:30245
is: HMDB00673

metaM hxcoa m
name: Hexanoyl-CoA (n-C6:0CoA)
boundary condition: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB06522
constant: false

metaM ksi deg16 l
type: Species
is: CHEBI:57455
name: keratan sulfate I, degradation product 16
notes: FORMULA: C160H258N11O137S7 CHARGE: -7
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01354
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR CO2t
kinetic law: MODEL1310110006#
type: Reaction
is: SBO:0000185
reversible: true
name: CO2 transporter via diffusion
fast: false
is described by: ECO:0000000
reactant: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD

metaR r0055
is: SBO:0000176
type: Reaction
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.8
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
reversible: true
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.2.7
is described by: ECO:0000000

metaR 7DHFtm
kinetic law: MODEL1310110006#
name: 7-glutamyl-DHF transport,m mitochondrial
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:unknown mechanism. IT
product: MODEL1310110006#
is: SBO:0000185
fast: false
reversible: false
reactant: MODEL1310110006#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_04d1415d_c535_40f3_ac69_c67af521df98
type: Species
initial amount: NaN
initial concentration: NaN
name: ALDH2
is: P05091
boundary condition: true
is: SBO:0000252
is encoded by: hsa:217
constant: false
has only substance units: false

metaR RE2973C
type: Reaction
product: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.1.154
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110006#
name: RE2973
kinetic law: MODEL1310110006#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.137

metaR r1654
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
is: SBO:0000185
product: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR RE3001M
type: Reaction
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.1.34
modifier: MODEL1310110006#
product: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
fast: false
name: RE3001
is described by: ECO:0000000

metaR OBDHc
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
product: MODEL1310110006#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110006#
type: Reaction
fast: false
reactant: MODEL1310110006#
name: 2-Oxobutanoate dehydrogenase, cytosolic
is described by: ECO:0000000

metaR r1546
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_57032b76_4467_481d_ad3d_720e80bf63d9
initial amount: NaN
constant: false
is encoded by: hsa:AI601100
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: _AI601100_1_m

metaM 3odcoa m
boundary condition: false
is: CHEBI:28528
name: 3-Oxodecanoyl-CoA
initial concentration: 1.0
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: SBO:0000247
constant: false
is: HMDB03939
initial amount: NaN
has only substance units: false
type: Species

metaM hs deg5 l
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
is: SBO:0000247
initial amount: NaN
is: HMDB00158
type: Species
is: CHEBI:17895
has only substance units: false
name: heparan sulfate, degradation product 5
constant: false
boundary condition: false
initial concentration: 1.0

metaR r1651
reactant: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
modifier: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaR FAEL205
type: Reaction
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reversible: false
name: fatty-acyl-CoA elongation (n-C20:5CoA)
is described by: ECO:0000000
product: MODEL1310110006#
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
is: SBO:0000176

metaM malthp e
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: maltoheptaose
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
has only substance units: false
is: C01936

metaM dgdp n
boundary condition: false
has only substance units: false
is: CHEBI:58595
is: SBO:0000247
type: Species
is: HMDB00960
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
name: dGDP(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_85056810_4934_43b3_b977_aa49f4c4a3dc
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5295
type: Species
has only substance units: false
name: PIK3R1
constant: false
is: P27986
boundary condition: true
is: SBO:0000252

metaR BAAT3x
is: SBO:0000176
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:third version analog added as per KEGG NJ
name: bile acid Coenzyme A: amino acid N-acyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
fast: false
type: Reaction
product: MODEL1310110006#
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_90f3f142_8ff7_4ed3_b408_ca146bacc560
constant: false
has part: P13804
type: Species
initial amount: NaN
name: ETFA:ETFB
is: SBO:0000297
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2108
is encoded by: hsa:2109

metaR GLUDxm
reversible: true
reactant: MODEL1310110006#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.4.1.3
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
name: glutamate dehydrogenase (NAD) (mitochondrial)

metaR r1936
fast: false
modifier: MODEL1310110006#
product: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM btn e
has only substance units: false
initial amount: NaN
name: Biotin
is: HMDB00030
is: CHEBI:3420
initial concentration: 1.0
is: C00120
boundary condition: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: SBO:0000247
constant: false
type: Species

metaM acnacngalgbside hs e
has only substance units: false
is: C00036
initial amount: NaN
is: CHEBI:3338
initial concentration: 1.0
type: Species
is: HMDB00223
constant: false
boundary condition: false
is: SBO:0000247
name: disialyl galactosylgloboside
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2

metaR r1547
type: Reaction
reactant: MODEL1310110006#
fast: false
reversible: true
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_37a7787a_01fa_4ad5_8d27_01dca5c0668e
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:AI824319
is: SBO:0000252
name: _AI824319_1_r
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_ebe8e199_bfbc_4a22_a11e_7c6bf8ab0761
is: D3DX95
is encoded by: hsa:1103
initial amount: NaN
name: CHAT
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN

metaM galgluside hs g
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00295
name: galactosyl glucosyl ceramide
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
constant: false
initial concentration: 1.0
initial amount: NaN
is: C00015
is: CHEBI:58223
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_ff55d216_aa28_4dd5_8f8e_aa80d568a7be
constant: false
is encoded by: hsa:5208
is: O60825
boundary condition: true
has only substance units: false
initial amount: NaN
name: PFKFB2
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_e6815275_e70b_4414_838f_b76d0ccc0187
is encoded by: hsa:11254
type: Species
initial concentration: NaN
is: Q9UN76
constant: false
name: SLC6A14
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

metaR r1652
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110006#
kinetic law: MODEL1310110006#

metaM mercppyr c
initial concentration: 1.0
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
is: HMDB01368
type: Species
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:57678
name: 3-mercaptopyruvate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_4b17abea_0ef9_4ca2_90b6_f3900c5f3cb2
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: _AL050025_1_c
constant: false
is encoded by: hsa:AL050025

metaR FUMAC
is described by: ECO:0000269
modifier: MODEL1310110006#
reactant: MODEL1310110006#
product: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
is: SBO:0000176
type: Reaction
name: fumarylacetoacetase
fast: false
is version of: http://identifiers.org/ec-code/3.7.1.2
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD

metaM coa c
is: C00010
type: Species
initial amount: NaN
is: CHEBI:3312
has only substance units: false
initial concentration: 1.0
name: Coenzyme A
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
is: HMDB01423
is: SBO:0000247
constant: false

metaR r0885
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
kinetic law: MODEL1310110006#
fast: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:

metaR CAATPS
kinetic law: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.8
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
is: SBO:0000185
fast: false
is described by: ECO:0000269
reactant: MODEL1310110006#
reversible: false
modifier: MODEL1310110006#
name: Ca ATPase
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_97f9fd47_4bd1_42b4_8852_0428f33ac5fd
constant: false
is: SBO:0000252
type: Species
is: P35219
name: CA8
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:767
initial amount: NaN

metaM ditp c
constant: false
boundary condition: false
name: dITP(4-)
initial amount: NaN
is: HMDB03537
is: CHEBI:61382
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345

metaR r1418
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
fast: false
is: SBO:0000176
product: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110006#
type: Reaction

metaR r1937
is: SBO:0000185
kinetic law: MODEL1310110006#
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110006#
fast: false
modifier: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110006#

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaR VALTA
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110006#
name: valine transaminase
type: Reaction
fast: false
product: MODEL1310110006#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.6.1.42

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

metaM 3thexddcoa c
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
boundary condition: false
initial amount: NaN
constant: false
is: HMDB02014
name: 3-hydroxy trans7,10-hexadecadienoylcoa
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247

metaR C14OHc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecanoylcarnitine
type: Reaction

metaR r1544
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR PGS
is version of: http://identifiers.org/ec-code/1.14.99.1
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
reversible: false
name: Prostaglandin G/H synthase
product: MODEL1310110006#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269

metaM fe3 e
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:29034
name: Fe3+
is: SBO:0000247
is: HMDB12943

http://identifiers.org/biomodels.db/MODEL1310110006#_15ee8573_a588_43f9_8508_ce37006535e8
name: MGAT3
is: Q09327
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4248
initial amount: NaN
constant: false
boundary condition: true

metaM hgentis c
initial amount: NaN
name: homogentisate
is: CHEBI:16169
constant: false
has only substance units: false
boundary condition: false
is: HMDB00130
initial concentration: 1.0
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_f0877c80_6e05_4eda_8482_5d356200be14
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is: P14550
is encoded by: hsa:10327
type: Species
name: AKR1A1
has only substance units: false

metaM gm3 hs g
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
is: SBO:0000247
initial amount: NaN
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
is: CHEBI:60065
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_cee71d5f_af73_42ba_8426_5812bf363e31
is: SBO:0000252
name: SLC25A16
is encoded by: hsa:8034
initial amount: NaN
is: P16260
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_bf698e1c_5c69_4485_9c57_ec33a6729797
has only substance units: false
name: IDH2
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is: P48735
initial amount: NaN
type: Species
is encoded by: hsa:3418

metaR BILIRED
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
reversible: false
name: Nad(p)h biliverdin reductase
product: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.24
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_ce7063af_358e_421a_b36a_209928eec081
is encoded by: hsa:1633
name: DCK
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: P27707
initial concentration: NaN

metaR C140CPT1
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

metaR DIGALSIDEtl
reversible: true
type: Reaction
name: digalside hs intracellular transport
is described by: ECO:0000000
reactant: MODEL1310110006#
is: SBO:0000185
product: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ

metaM lneldccrn m
constant: false
initial amount: NaN
initial concentration: 1.0
name: Linoelaidyl carnitine
boundary condition: false
is: HMDB06461
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+

metaM HC10852 r
name: palmitoleyl-CoA(4-)
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:61540
initial amount: NaN
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
boundary condition: false
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_5716db24_d3ec_4ea9_9ee5_d6db9505bbd8
initial concentration: NaN
is: SBO:0000252
is: O95573
has only substance units: false
initial amount: NaN
is encoded by: hsa:2181
name: ACSL3
constant: false
boundary condition: true
type: Species

metaM acnacngalgbside hs g
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: C00036
is: CHEBI:3338
name: disialyl galactosylgloboside
type: Species
is: HMDB00223
has only substance units: false
constant: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2

metaR FAOXC225C204x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_0508af0c_c5e7_4ff3_9168_c9029e10c2d1
initial concentration: NaN
is encoded by: hsa:23236
is: Q9NQ66
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PLCB1
type: Species
boundary condition: true
constant: false

metaM C02528 c
is: SBO:0000247
type: Species
name: chenodeoxycholate
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:36234
is: HMDB00518
boundary condition: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528

http://identifiers.org/biomodels.db/MODEL1310110006#_8017960f_3702_4a83_9f63_27a822403e31
is: SBO:0000297
constant: false
initial concentration: NaN
name: PIGF:PIGO
type: Species
has part: Q6IB04
is encoded by: hsa:84720
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:5281

http://identifiers.org/biomodels.db/MODEL1310110006#_47533e3c_73d9_4042_b7cb_4d016cc0b267
initial amount: NaN
is: SBO:0000252
name: ST3GAL1
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6482
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_478f3d5f_3cf7_4412_b96d_4acba5c047e0
is: P00439
name: PAH
boundary condition: true
initial amount: NaN
is encoded by: hsa:5053
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaM sphmyln hs g
is: SBO:0000247
type: Species
is: CHEBI:58216
name: sphingomyelin betaine
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_7ce59f38_a54f_4e75_92ca_085b40ae60da
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: Q9H845
initial amount: NaN
is encoded by: hsa:28976
name: ACAD9

metaM coa e
is: C00010
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01423
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
is: CHEBI:57287

metaR r1650
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000185
fast: false
product: MODEL1310110006#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM m4mpdol L r
boundary condition: false
is: CHEBI:37633
initial concentration: 1.0
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C1540H2528N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_metaR_EX_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIAb exchange
type: Reaction

metaM CE2432 m
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
boundary condition: false
is: SBO:0000247
constant: false
type: Species
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57795
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_329146f8_b731_4780_9a5e_d2a1458dc7e2
boundary condition: true
initial amount: NaN
type: Species
is: Q53HE2
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:7167
name: TPI1

metaM 3ttetddcoa c
name: 3-hydroxy trans5,8tetradecadienoyl coa
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB02014
initial concentration: 1.0
boundary condition: false

metaR LNLCCPT2
kinetic law: MODEL1310110006#
name: carnitine transferase
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110006#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
product: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR r2389
reversible: false
type: Reaction
modifier: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
kinetic law: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR FAOXC225C226m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_202910fb_7193_47c6_8d60_d036819c7e1b
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:51
is: Q15067
is: SBO:0000252
boundary condition: true
name: ACOX1

metaM arachdcoa x
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
name: arachidonoyl-CoA(4-)
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: HMDB06523
is: CHEBI:57368
initial amount: NaN

metaM hexdpencoa x
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
has only substance units: false
name: 2,4,7,10,13-hexadecapentaenoylcoa
is: HMDB02288
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_42d2ae2f_6166_4ffc_a01e_68f4e854bbb6
is: Q49AT3
type: Species
constant: false
name: B3GALNT1
has only substance units: false
boundary condition: true
is encoded by: hsa:8706
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaM ksi pre29 g
initial concentration: 1.0
is: CHEBI:28067
constant: false
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
is: SBO:0000247
type: Species
name: keratan sulfate I biosynthesis, precursor 29
initial amount: NaN
has only substance units: false
boundary condition: false

metaM tdec4ecoa m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial concentration: 1.0
is: C08277
is: HMDB00792
boundary condition: false
has only substance units: false
name: trans4decenoylcoa
constant: false
is: SBO:0000247
type: Species
initial amount: NaN

metaM hxcoa x
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB00705
name: Hexanoyl-CoA (n-C6:0CoA)
type: Species
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false

metaR r2388
modifier: MODEL1310110006#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110006#
reversible: false

metaM CE5854 e
constant: false
initial amount: NaN
is: CHEBI:27485
is: HMDB02710
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
initial concentration: 1.0
name: gama-CEHC-glucuronide
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false

metaR r0881
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
fast: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
name: Active transport
type: Reaction
is: SBO:0000185
reversible: false

metaM coa g
constant: false
is: CHEBI:57287
initial amount: NaN
name: coenzyme A(4-)
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
type: Species
has only substance units: false
is: HMDB01423
boundary condition: false
initial concentration: 1.0

metaM fadh2 x
type: Species
initial concentration: 1.0
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
boundary condition: false
name: FADH2(2-)
is: HMDB01197
is: CHEBI:58307
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false

metaR EX fald LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of formaldehyde
type: Reaction

metaM ksi pre20 g
has only substance units: false
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28067
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 20
constant: false
type: Species

metaM dsmsterol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:17737
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB02719
name: desmosterol

metaR FAOXC3DC
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: malonylcoa-->malonylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_fd42f1d5_0262_4d13_9154_cf839482b6b2
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is: A0S0A7
initial concentration: NaN
type: Species
is encoded by: hsa:4846
name: NOS3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_13a3f04b_afcb_4f9e_a735_7b1f991e56e4
has only substance units: false
is: Q53Y25
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2645
type: Species
name: GCK

http://identifiers.org/biomodels.db/MODEL1310110006#_959513b3_e05f_4cca_97d1_6758dccae7a5
is encoded by: hsa:9469
initial concentration: NaN
type: Species
is: Q7LGC8
is: SBO:0000252
constant: false
name: CHST3
has only substance units: false
initial amount: NaN
boundary condition: true

metaR r2387
fast: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

metaR SPHMYLNtg
reactant: MODEL1310110006#
fast: false
name: sphingomyelin intracellular transport
reversible: true
type: Reaction
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is described by: ECO:0000000

metaR r1548
type: Reaction
reactant: MODEL1310110006#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110006#
is: SBO:0000185
kinetic law: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaM acnacngalgbside hs c
initial concentration: 1.0
is: C00036
initial amount: NaN
is: CHEBI:3338
boundary condition: false
type: Species
is: HMDB00223
is: SBO:0000247
constant: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
name: disialyl galactosylgloboside
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_d621ca2b_624e_4317_a7a8_a2d439215289
initial concentration: NaN
initial amount: NaN
name: UCK1
is: Q5JT09
is: SBO:0000252
constant: false
is encoded by: hsa:83549
type: Species
has only substance units: false
boundary condition: true

metaM txa2 c
is: HMDB01452
name: thromboxane A2(1-)
initial amount: NaN
is: CHEBI:57445
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_888a2933_e7e3_4027_8769_af389c0052bd
type: Species
constant: false
initial concentration: NaN
name: NDUFA2
is: O43678
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:4695
boundary condition: true

metaM lnlccoa m
is: http://identifiers.org/pubchem.compound/5462164
type: Species
constant: false
name: linoleic coenzyme A
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01064
initial amount: NaN
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983

metaM mi1p D c
initial amount: NaN
constant: false
has only substance units: false
is: HMDB02985
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58433
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
boundary condition: false
name: 1D-myo-inositol 1-phosphate(2-)

metaR BTNDe
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/3.5.1.12
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
is described by: ECO:0000269
modifier: MODEL1310110006#
name: biotinidase (biotin), extracellular
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_9ebbb57c_6574_43b1_bfb0_90c6b244d7f4
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:240
is: P09917
name: ALOX5
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_6cfd7757_cbeb_4256_9e3e_8ebbb10a0722
is encoded by: hsa:376497
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SLC27A1
type: Species

metaR LNLCCPT1
kinetic law: MODEL1310110006#
fast: false
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000269
reactant: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
is: SBO:0000176
product: MODEL1310110006#
reversible: false

metaM sphmyln hs c
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial concentration: 1.0
constant: false
is: CHEBI:58216
is: SBO:0000247
boundary condition: false
name: sphingomyelin betaine

metaR NDP7er
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000176
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD

metaR r2386
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: false
product: MODEL1310110006#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110006#
is described by: ECO:0000000
fast: false

metaR GUAt
modifier: MODEL1310110006#
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
fast: false
reversible: true
name: Guanine transport
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110006#_bab524c6_9877_4006_a8b5_01895cd5e712
initial amount: NaN
is: B4DER4
type: Species
is encoded by: hsa:5291
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
name: PIK3CB

metaM CE4794 m
type: Species
constant: false
name: cis-6-dodecenoyl-CoA
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57923
has only substance units: false
initial amount: NaN

metaR NRVNCCOAtx
type: Reaction
product: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
reactant: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_f4cce12f_1c4b_4a11_a3cc_93df4b2e6103
is: SBO:0000297
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: SLC7A8:SLC3A2
has part: Q9UHI5
initial concentration: NaN
boundary condition: true
is encoded by: hsa:23428

metaR r1549
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110006#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110006#

metaM 2dodtricoa x
constant: false
name: 2,6,9-dodecatrienoylcoa
is: HMDB11123
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: C05279
is: SBO:0000247
initial concentration: 1.0

metaM malt e
boundary condition: false
is: C00208
type: Species
is: CHEBI:17306
has only substance units: false
constant: false
initial concentration: 1.0
name: Maltose
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
is: HMDB00163
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_4a715977_f920_4b59_a8a7_159ab8f466be
type: Species
is: Q8TCD5
name: NT5C
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:30833

metaM ppcoa m
is: C00100
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial amount: NaN
type: Species
is: CHEBI:57392
has only substance units: false
name: Propanoyl-CoA
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01275
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_b3fe039b_c950_4805_8494_32f88ab6e9e0
is encoded by: hsa:AI024818
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
name: _AI024818_1_c
initial amount: NaN
boundary condition: true

metaM crm hs c
boundary condition: false
constant: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:52639
has only substance units: false
initial amount: NaN
name: N-acylsphingosine

metaM dec47dicoa m
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
name: 4,7-decadienoylcoa
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_3c9ff123_b182_4197_9e67_f2b65e467eeb
is: P07327
name: ADH1A
is: SBO:0000252
type: Species
is encoded by: hsa:124
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_e77b1253_7c46_40b4_9c43_080853a41c65
name: PIGM
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:93183
is: Q9H3S5
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN

metaR HIStN1
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
fast: false
reversible: true
name: Histidine transport (Na, H coupled)
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185
modifier: MODEL1310110006#
type: Reaction
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_ac4a4a75_fb0a_489a_9fdc_6533a24e620f
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: MAN2A1
is: Q16706
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4124
constant: false
type: Species

metaR NDP7ex
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110006#
name: nucleoside-diphosphatase (UDP), extracellular
is: SBO:0000176
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
product: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#

metaR r0423
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
product: MODEL1310110006#
reactant: MODEL1310110006#

metaR r0178
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.5.1.21
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
kinetic law: MODEL1310110006#
fast: false
type: Reaction
modifier: MODEL1310110006#
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
product: MODEL1310110006#
reversible: true
is: SBO:0000176

metaR GALASE3ly
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
reversible: false

metaR ABO7g
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.37
fast: false
type: Reaction
product: MODEL1310110006#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_metaR_EX_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1 exchange
type: Reaction

metaM cl c
initial amount: NaN
name: Chloride
is: C00115
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00492
boundary condition: false
is: CHEBI:3966
notes: FORMULA: Cl CHARGE: -1
type: Species

metaR S6T6g
modifier: MODEL1310110006#
is: SBO:0000176
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110006#
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_f5131131_7e32_4495_ac5a_51c2e3426e4a
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:51227

metaM ac c
boundary condition: false
name: acetate
type: Species
has only substance units: false
is: HMDB00042
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:30089
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_21878187_82c1_4b3c_a92e_75e56bd281cd
name: PYCRL
is: Q53H96
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:65263

metaR S6TASE16ly
type: Reaction
fast: false
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000
product: MODEL1310110006#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_60e445a5_026a_4487_ae35_eb6bc2e1106b
boundary condition: true
name: ALPI
is: P09923
constant: false
has only substance units: false
is encoded by: hsa:248
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

metaR MAGt
type: Reaction
reactant: MODEL1310110006#
is described by: ECO:0000269
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110006#
fast: false
name: monoacylglycerol 2 transport

metaR r0424
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.1.4
reversible: true
type: Reaction
product: MODEL1310110006#
modifier: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

metaR r0179
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27
reversible: true
product: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
modifier: MODEL1310110006#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
type: Reaction
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:

metaM 4abut c
is: C00334
boundary condition: false
is: SBO:0000247
name: 4-Aminobutanoate
constant: false
type: Species
initial concentration: 1.0
is: HMDB00112
notes: FORMULA: C4H9NO2 CHARGE: 0
has only substance units: false
initial amount: NaN
is: CHEBI:3628

metaM nad c
name: Nicotinamide adenine dinucleotide
constant: false
is: CHEBI:57540
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3305
type: Species
is: HMDB00902
boundary condition: false
is: C00003

http://identifiers.org/biomodels.db/MODEL1310110006#_6fa6305d_729b_4f71_b046_d33cea672ba0
is: SBO:0000252
boundary condition: true
name: SLC13A4
type: Species
is: Q9UKG4
initial concentration: NaN
is encoded by: hsa:26266
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_93dc1e71_2360_4c56_9a4f_26b978bafab0
has only substance units: false
name: HYAL3
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:8372
type: Species
initial concentration: NaN
is: O43820

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaM lnlc e
is: HMDB00673
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
initial concentration: 1.0
is: CHEBI:30245
has only substance units: false
constant: false
type: Species
boundary condition: false
name: linoleate

http://identifiers.org/biomodels.db/MODEL1310110006#_ec30b8cd_73b1_432e_9a45_01d9cd83be98
type: Species
constant: false
is: Q96CD2
boundary condition: true
initial amount: NaN
has only substance units: false
name: PPCDC
is: SBO:0000252
is encoded by: hsa:60490
initial concentration: NaN

metaM lnlccoa r
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: linoleic coenzyme A
boundary condition: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: HMDB01064
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN

metaR CLS hs
is: SBO:0000176
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
name: cardiolipin synthase (homo sapiens)
kinetic law: MODEL1310110006#
reversible: false
fast: false
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_004a7130_8d5b_47a9_9054_b71191df4b80
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:54407
initial concentration: NaN
boundary condition: true
name: SLC38A2
type: Species
is: Q96QD8

metaR S6T14g
reversible: false
fast: false
is: SBO:0000176
product: MODEL1310110006#
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110006#

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR FAOXC141C141OHm
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

metaM itp c
type: Species
name: ITP(3-)
is: CHEBI:57614
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: HMDB00189
boundary condition: false
has only substance units: false

metaR GTHRDt
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110006#
type: Reaction
fast: false
name: Glutathione transport into mitochondria
reactant: MODEL1310110006#
product: MODEL1310110006#
reversible: true

metaR HPDCACRNCPT1
name: carnitine fatty-acyl transferase
modifier: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
type: Reaction
reactant: MODEL1310110006#
reversible: false
is: SBO:0000176
is described by: ECO:0000000

metaM cl e
is: HMDB00492
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: C00115
notes: FORMULA: Cl CHARGE: -1
is: CHEBI:3966
constant: false
is: SBO:0000247
name: Chloride
initial amount: NaN

metaR THRGLYexR
reactant: MODEL1310110006#
is: SBO:0000185
modifier: MODEL1310110006#
reversible: true
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-threonine/glycine reversible exchange
product: MODEL1310110006#
type: Reaction

metaR LGTHL
kinetic law: MODEL1310110006#
reversible: false
is described by: ECO:0000269
name: lactoylglutathione lyase
is version of: http://identifiers.org/ec-code/4.4.1.5
reactant: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
product: MODEL1310110006#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_a6f93ada_829b_4557_842e_5c9b706af741
constant: false
is: SBO:0000252
is encoded by: hsa:64077
has only substance units: false
name: LHPP
initial concentration: NaN
initial amount: NaN
is: Q9H008
boundary condition: true
type: Species

metaM dolmanp L r
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
boundary condition: false
initial amount: NaN
is: CHEBI:15809
initial concentration: 1.0
constant: false
has only substance units: false
name: Dolichyl phosphate D-mannose, human liver homolog
is: SBO:0000247
type: Species

metaM acald c
is: HMDB00990
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:15343
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
name: acetaldehyde
type: Species

metaR PGK
name: phosphoglycerate kinase
is version of: http://identifiers.org/ec-code/2.7.2.3
product: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110006#
fast: false
is described by: ECO:0000134
is: SBO:0000176
reversible: true
reactant: MODEL1310110006#
type: Reaction

metaM hs deg17 l
has only substance units: false
initial amount: NaN
name: heparan sulfate, degradation product 17
initial concentration: 1.0
is: CHEBI:21338
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
constant: false
is: HMDB02704

http://identifiers.org/biomodels.db/MODEL1310110006#_0f09ed21_84e6_4cad_9d4b_9d2ddb8f335b
name: PIGA
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: B3KUV7
initial amount: NaN
boundary condition: true
is encoded by: hsa:5277
constant: false

metaR r0426
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
kinetic law: MODEL1310110006#
type: Reaction
reversible: true
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.5.1.34
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
modifier: MODEL1310110006#
fast: false
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_metaR_FUCFUCFUCGALACGLC13GALACGLCGAL14ACGLCGALGLUSIDEte
is described by: ECO:0000000
name: blood group intracellular transport
type: Reaction
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

metaM for c
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
has only substance units: false
is: CHEBI:15740
is: C00058
is: SBO:0000247
name: Formate
is: HMDB00142
type: Species
initial amount: NaN

metaR PTDCACRNt
kinetic law: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110006#
name: pentadecanoate transport into the mitochondria
modifier: MODEL1310110006#
product: MODEL1310110006#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_eeae443d_1a1c_4c6b_95f9_44634cf9fd03
initial concentration: NaN
is encoded by: hsa:8833
is: P49915
type: Species
has only substance units: false
name: GMPS
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_9141a075_9675_4acb_af86_d6d28d3beeb8
initial amount: NaN
is: B3KTQ4
has only substance units: false
initial concentration: NaN
name: B3GALNT1
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:8706

metaR HPDCACRNCPT2
reversible: false
kinetic law: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
name: heptadecanoate transport into the mitochondria
reactant: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110006#_0cf57c3c_94ef_441d_a9c9_b8e421268276
constant: false
name: _NOS2A_1_c
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:NOS2A

http://identifiers.org/biomodels.db/MODEL1310110006#_a79a6846_89c6_4940_9c04_16e7b96ec846
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:10768
initial concentration: NaN
is: SBO:0000252
type: Species
name: AHCYL1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_4dbba230_68be_4466_9004_0644a777beb9
is encoded by: hsa:8818
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: O94777
name: DPM2
constant: false

metaM 4abut e
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: HMDB00112
name: 4-Aminobutanoate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0
is: CHEBI:3628
is: C00334
has only substance units: false

metaM ocdca e
is: C01530
has only substance units: false
is: CHEBI:25629
initial concentration: 1.0
constant: false
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
boundary condition: false
name: octadecanoate (n-C18:0)
initial amount: NaN
type: Species
is: HMDB00827
is: SBO:0000247

metaR EX 3ivcrn
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaR NDPK1n
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
reversible: true
kinetic law: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
modifier: MODEL1310110006#
reactant: MODEL1310110006#

metaR CHOLt4
reactant: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
modifier: MODEL1310110006#
fast: false
product: MODEL1310110006#
kinetic law: MODEL1310110006#
name: choline, sodium cotransport
reversible: true
is described by: ECO:0000269
is: SBO:0000185

metaM lnlc c
has only substance units: false
boundary condition: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
initial concentration: 1.0
is: HMDB00673
initial amount: NaN
constant: false
name: linoleate
type: Species
is: SBO:0000247
is: CHEBI:30245

metaM HC02206 e
initial amount: NaN
constant: false
name: prostaglandin C1(1-)
type: Species
is: CHEBI:57399
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR EX 3octdece1crn
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaM biocyt e
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/7886
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial concentration: 1.0
is: C05552
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB03134
name: Biocytin

metaR S3TASE3ly
is: SBO:0000176
fast: false
reversible: true
product: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
name: N-acetylglucosamine-3-sulfatase, lysosomal
reactant: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

metaM glcur c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
constant: false
has only substance units: false
is: CHEBI:15748
name: D-glucuronate
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB00127

metaM acald e
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:15343
name: acetaldehyde
constant: false
is: SBO:0000247
is: HMDB00990
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084

metaR ACHtn
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
is: SBO:0000185
kinetic law: MODEL1310110006#
type: Reaction
name: Acetylcholin transport, nuclear trhough pores
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_2bcca624_99d1_4440_b55a_f77b3a40ab79
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23517
initial concentration: NaN
type: Species
name: SKIV2L2
initial amount: NaN
has only substance units: false
is: Q3MHC9
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_5b3d70de_dfec_4c52_80ff_a6c262f6d191
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:AI373818
name: _AI373818_1_m
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM ivcrn e
has only substance units: false
initial amount: NaN
name: isovaleryl carnitine
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C12H23NO4 CHARGE: 0
boundary condition: false
constant: false
is: HMDB00688

metaM elaid e
name: elaidate
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:30825
type: Species
is: HMDB00573

http://identifiers.org/biomodels.db/MODEL1310110006#_dd8fff48_c0da_4d2b_922c_28c9f80c9152
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:160851
initial amount: NaN
name: DGKH
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q86XP1

metaR CSPG Atly
name: chondroitin sulfate A transport, extracellular to lysosome
fast: false
kinetic law: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
product: MODEL1310110006#
is described by: ECO:0000000
reversible: false

metaR DRPA
reversible: false
type: Reaction
name: deoxyribose-phosphate aldolase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110006#

metaR G3PD1
name: glycerol-3-phosphate dehydrogenase (NAD)
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is version of: http://identifiers.org/ec-code/1.1.1.8
kinetic law: MODEL1310110006#
is described by: ECO:0000269
reactant: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000176

metaR L LACt2r
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
reversible: true
fast: false
name: L-lactate reversible transport via proton symport
is: SBO:0000185

metaR r0280
modifier: MODEL1310110006#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40

metaM ascb L c
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: SBO:0000247
is: HMDB00044
is: CHEBI:38290
name: L-ascorbate
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR r1990
fast: false
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110006#
reactant: MODEL1310110006#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110006#

metaM for e
is: CHEBI:15740
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00142
type: Species
is: SBO:0000247
initial amount: NaN
name: formate
constant: false

metaM andrstrn r
initial concentration: 1.0
is: SBO:0000247
name: androsterone
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
is: CHEBI:16032
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00031
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_metaR_FUCFUCFUCGALACGLC13GALACGLCGAL14ACGLCGALGLUSIDEtg
product: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
name: blood group intracellular transport
fast: false
reversible: true
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reactant: MODEL1310110006#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110006#_dbb10000_902b_413d_80dc_4e4db1a050d8
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:5464
is: Q15181
name: PPA1
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252

metaM fe3 c
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: Fe CHARGE: 3
initial concentration: 1.0
is: SBO:0000247
name: Fe3+
is: HMDB12943
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_c2db6640_c3fb_4f91_8162_bafd5d54ae6f
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:8876
has only substance units: false
name: VNN1
constant: false
is: SBO:0000252
boundary condition: true
is: O95497

metaM ocdca c
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
constant: false
initial concentration: 1.0
is: CHEBI:25629
has only substance units: false
type: Species
is: HMDB00827
is: SBO:0000247
name: stearate
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_34cb7643_3ce3_4f5b_b44f_cf4084ba4cf1
has only substance units: false
is: SBO:0000252
name: GK2
type: Species
constant: false
is encoded by: hsa:2712
is: Q14410
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR Htx
reversible: true
reactant: MODEL1310110006#
name: H transporter, peroxisome
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110006#
fast: false
type: Reaction
product: MODEL1310110006#
is: SBO:0000185

metaM m1mpdol L c
is: CHEBI:28067
notes: FORMULA: C1360H2228N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
type: Species
boundary condition: false
has only substance units: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM 3hibutcoa m
is: CHEBI:28259
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
name: (S)-3-Hydroxyisobutyryl-CoA
is: HMDB01052
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_9d59cf33_7030_4762_8caa_f563d09abff5
name: ALDH9A1
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:223
is: P49189
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR G12MT2 L
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110006#
product: MODEL1310110006#
fast: false
type: Reaction
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)

metaR PDX5PO
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110006#
is: SBO:0000176
fast: false
reactant: MODEL1310110006#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.3.5
product: MODEL1310110006#
name: pyridoxine 5'-phosphate oxidase
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_3ed36674_941f_4ca3_b530_b4859ae69e2b
name: ACSL4
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2182
boundary condition: true
is: O60488
type: Species

metaR LEUTA
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
name: leucine transaminase
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
fast: false
type: Reaction
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_acglcgalacglcgal14acglcgalgluside_hs_g
is: CHEBI:26174
constant: false
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: (Gal)3 (Glc)1 (GlcNAc)3 (Cer)1
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_f1d72ef2_9f3e_4345_b7e5_79d97ac0f548
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: AK4
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:205

metaM 4hexdtetcoa x
initial amount: NaN
name: 4,7,10,13-hexadecatetraenoylcoa
initial concentration: 1.0
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB02288
constant: false

metaR DM ethamp r
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_f1359309_2a12_4e45_ad47_2c08b2712a24
is encoded by: hsa:65010
constant: false
name: SLC26A6
is: Q9NQU1
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR B3GNT51g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
is: SBO:0000176
notes: GENE_ASSOCIATION: (84002.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110006#
is described by: ECO:0000304
reactant: MODEL1310110006#
reversible: false
modifier: MODEL1310110006#
product: MODEL1310110006#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_155c851d_6cd5_46b4_b471_7e325f544e7c
is: Q9GZX3
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:4166
name: CHST6
has only substance units: false

metaM ksi pre33 g
is: HMDB00175
has only substance units: false
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: C00130
is: CHEBI:58053
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
name: keratan sulfate I biosynthesis, precursor 33

metaM 3octdece1coa m
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/5280355
name: 3-hydroxyoctadecenoylcoa
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false

metaR FAOXC18480m
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: false
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110006#
kinetic law: MODEL1310110006#

metaM biocyt c
is: HMDB03134
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
constant: false
is: C05552
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
name: Biocytin
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_46938682_e06f_41f5_adb3_9ed22e7fa688
is encoded by: hsa:6649
boundary condition: true
initial amount: NaN
type: Species
is: P08294
name: SOD3
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM ac e
name: acetate
has only substance units: false
boundary condition: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial amount: NaN
is: SBO:0000247
is: CHEBI:30089
initial concentration: 1.0
constant: false
type: Species
is: HMDB00042

metaR FAOXC226C227m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_5cc677fd_d82d_4bf3_b9cf_b428a2679758
is: Q8TEQ8
type: Species
name: PIGO
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:84720
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR NDPK1m
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
is: SBO:0000176
is described by: ECO:0000254
fast: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#

metaR BTNDm
is: SBO:0000176
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.12
reactant: MODEL1310110006#
name: biotinidase (biotin), mitochondrial
fast: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
type: Reaction
reversible: false

metaM btn c
is: HMDB00030
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1
constant: false
is: C00120
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:3420
boundary condition: false
name: Biotin

metaM cysam c
is: HMDB02991
initial concentration: 1.0
boundary condition: false
name: cysteaminium
is: CHEBI:58029
is: SBO:0000247
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
constant: false
has only substance units: false
type: Species
initial amount: NaN

metaM ivcrn c
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00688
name: isovaleryl carnitine
initial concentration: 1.0
constant: false
notes: FORMULA: C12H23NO4 CHARGE: 0
initial amount: NaN
has only substance units: false

metaR ICDHyrm
product: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
is described by: ECO:0000269
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110006#
type: Reaction
name: Isocitrate dehydrogenase (NADP+)
is version of: http://identifiers.org/ec-code/1.1.1.42
modifier: MODEL1310110006#

metaM 3hdececrn c
boundary condition: false
notes: FORMULA: C23H43NO5 CHARGE: 0
is: HMDB02014
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: 3-hydroxyhexadecenoylcarnitine
is: SBO:0000247

metaM elaid c
name: elaidate
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:30825
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
is: HMDB00573

http://identifiers.org/biomodels.db/MODEL1310110006#_8e8c5e37_3dda_4f97_9887_77dda04e362d
type: Species
has only substance units: false
boundary condition: true
name: _T83654_1_e
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:T83654

metaR RE1898C
is: SBO:0000176
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
name: RE1898
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
product: MODEL1310110006#

metaM m2mpdol L c
is: CHEBI:28049
boundary condition: false
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
is: SBO:0000247

metaR 34DHXMANDACOX NADP
fast: false
modifier: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: true
is described by: ECO:0000269

metaM asp L m
constant: false
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00191
type: Species
is: CHEBI:29991
name: L-aspartate(1-)
is: SBO:0000247

metaR r0310
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
reversible: false
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3

metaR C226CPT1
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110006#
fast: false
reversible: false
name: carnitine C22:6 transferase
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_2feb5b3e_d703_4720_bae8_a661d320ceb8
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: DLAT
boundary condition: true
type: Species
is encoded by: hsa:1737
is: Q86YI5

http://identifiers.org/biomodels.db/MODEL1310110006#_cfa08cd0_7462_4066_b232_10d72dc859c9
is encoded by: hsa:6526
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: SLC5A3
has only substance units: false
is: SBO:0000252
is: P53794
initial amount: NaN

metaR r0998
product: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
name: Facilitated diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110006#_e1d2ef27_fc2f_4659_b372_d59cd1bc75d2
initial amount: NaN
type: Species
name: HSD11B1
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:3290
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_4055a77e_0e77_451f_a741_086053b2fd5b
is encoded by: hsa:6581
boundary condition: true
is: SBO:0000252
name: SLC22A3
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q5SYN6
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_79d8bd07_3426_4d2e_9459_1e8ac740b3be
constant: false
is: SBO:0000252
is encoded by: hsa:3707
has only substance units: false
name: ITPKB
boundary condition: true
is: P27987
initial amount: NaN
initial concentration: NaN
type: Species

metaR r0170
is: SBO:0000176
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
is described by: ECO:0000000
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reactant: MODEL1310110006#
fast: false
product: MODEL1310110006#
reversible: true
type: Reaction
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.1.40

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaR C81CRNe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_4737ea4f_b759_4396_89e7_f505af99f7f7
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:3712
is: B3KVI7
name: IVD
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_60a8ed44_8340_4dd9_84ca_28b29537dd57
is encoded by: hsa:55350
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:8875
type: Species
name: VNN3:VNN2:VNN1
is: SBO:0000297
has part: O95498
initial concentration: NaN
boundary condition: true

metaR C6DCc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

metaR GLYt2r
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000304
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110006#
name: glycine reversible transport via proton symport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_3f8f8298_4456_4fa0_8fda_638bb36f1430
boundary condition: true
is encoded by: hsa:23439
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: ATP1B4
is: SBO:0000252
is: Q9UN42
initial amount: NaN

metaR RE0915E
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000
modifier: MODEL1310110006#
name: RE0915
product: MODEL1310110006#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#

metaM ach c
is: HMDB00895
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
type: Species
is: SBO:0000247
name: acetylcholine
initial concentration: 1.0
is: CHEBI:15355
initial amount: NaN
constant: false
has only substance units: false

metaM 3mgcoa m
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
is: HMDB01057
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:57346
name: trans-3-methylglutaconyl-CoA(5-)
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR FACOAL1812
reactant: MODEL1310110006#
name: fatty-acid--CoA ligase
product: MODEL1310110006#
fast: false
reversible: true
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR S6TASE1ly
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176
product: MODEL1310110006#
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is described by: ECO:0000000
fast: false

metaR 10FTHFtm
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
product: MODEL1310110006#
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
type: Reaction

metaR C226CPT2
reactant: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
name: C226 transport into the mitochondria
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110006#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110006#_c1f07680_beab_4079_9e97_8b75f128c45f
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:23563
name: CHST5
is: Q9GZS9
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR r0311
modifier: MODEL1310110006#
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.9
product: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction

metaM HC00250 e
constant: false
is: CHEBI:29919
boundary condition: false
has only substance units: false
name: hydrosulfide
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: SBO:0000247
type: Species

metaM hxcoa c
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
is: HMDB13130
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
name: Hexanoyl-CoA (n-C6:0CoA)

metaR CLFORtex
is described by: ECO:0000304
name: chloride transport via formate countertransport
reversible: false
is: SBO:0000185
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
modifier: MODEL1310110006#
fast: false

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR FAOXC226205m
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
modifier: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110006#
name: Beta oxidation of long chain fatty acid

metaR S6TASE12ly
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110006#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110006#
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110006#
is described by: ECO:0000000

metaM thm c
is: C00378
name: Thiamin
constant: false
notes: FORMULA: C12H17N4OS CHARGE: 1
is: SBO:0000247
is: HMDB00235
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:0

metaM fadh2 m
name: Flavin adenine dinucleotide reduced
is: CHEBI:58307
constant: false
is: SBO:0000247
is: HMDB01197
is: C01352
initial concentration: 1.0
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
has only substance units: false
initial amount: NaN
boundary condition: false

metaM 2dodtricoa m
initial amount: NaN
name: 2,6,9-dodecatrienoylcoa
boundary condition: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
constant: false
is: HMDB11123
is: SBO:0000247
is: C05279
has only substance units: false
initial concentration: 1.0
type: Species

metaR RETFA
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110006#
name: retinol acyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110006#
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_28458ace_e1ee_42ba_94bf_b08fc88b67ff
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: _BE966236_1_c
initial concentration: NaN
is encoded by: hsa:BE966236

metaR DUDPtn
reversible: true
reactant: MODEL1310110006#
name: dUDP nuclear transport
fast: false
kinetic law: MODEL1310110006#
type: Reaction
is: SBO:0000185
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000

metaR OMPDC
kinetic law: MODEL1310110006#
name: orotidine-5'-phosphate decarboxylase
is: SBO:0000176
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
product: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.10

metaM 3hdececrn e
notes: FORMULA: C23H43NO5 CHARGE: 0
has only substance units: false
constant: false
boundary condition: false
name: 3-hydroxyhexadecenoylcarnitine
is: HMDB02068
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species

metaR r0999
fast: false
reactant: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110006#_fcc428d3_2404_4b1f_acb1_7804ccb73686
has only substance units: false
is: SBO:0000252
type: Species
constant: false
name: CA9
is encoded by: hsa:768
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q16790

metaR r0281
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
modifier: MODEL1310110006#
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
type: Reaction
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/5.3.1.6
reactant: MODEL1310110006#
reversible: true

metaR r1993
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_e2a231df_b62a_45df_ba27_e227ec0d96a6
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
name: RDH12
is: Q96NR8
constant: false
has only substance units: false
is encoded by: hsa:145226

metaR PNTK
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000269
type: Reaction
name: pantothenate kinase
product: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.33
is: SBO:0000176
reversible: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR EX lneldc LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoelaidic acid exchange
type: Reaction

metaR GLUt2m
name: L-glutamate reversible transport via proton symport, mitochondrial
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110006#
product: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
is: SBO:0000185
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (83733.1) or (8604.1) or (79751.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD

metaR TMNDNCt
product: MODEL1310110006#
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110006#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion

metaR H2Oter
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110006#
type: Reaction
name: H2O endoplasmic reticulum transport

metaM glcur e
name: D-glucuronate
constant: false
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
type: Species
is: CHEBI:15748
is: HMDB00127
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_abe87bb1_e871_4b8c_856b_82f041b6b751
is encoded by: hsa:6390
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is: P21912
constant: false
initial amount: NaN
name: SDHB

http://identifiers.org/biomodels.db/MODEL1310110006#_412e48d5_0ae1_49ea_b27e_9f2b34e86d5d
constant: false
is encoded by: hsa:27034
initial amount: NaN
name: ACAD8
is: Q6ZWP6
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaR URIt
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
name: uridine facilated transport in cytosol
reactant: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110006#
fast: false
reversible: true
modifier: MODEL1310110006#

metaM ascb L e
type: Species
initial concentration: 1.0
has only substance units: false
name: L-ascorbate
is: SBO:0000247
is: HMDB00044
is: CHEBI:38290
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074

metaR ACOAD9m
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
fast: false
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM dec47dicoa x
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/16019966
name: 4,7-decadienoylcoa
has only substance units: false
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

metaM subeac c
constant: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C8H12O4 CHARGE: -2
has only substance units: false
is: HMDB00893
initial concentration: 1.0
is: SBO:0000247
name: suberic acid

metaM HC00250 c
is: CHEBI:29919
initial concentration: 1.0
type: Species
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
name: hydrosulfide
has only substance units: false

metaM 2decdicoa x
is: http://identifiers.org/pubchem.compound/16019966
name: 2,7-decadienoylcoa
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
has only substance units: false
constant: false
is: SBO:0000247

metaM fprica c
type: Species
constant: false
initial amount: NaN
is: HMDB01439
is: SBO:0000247
has only substance units: false
boundary condition: false
is: C04734
is: CHEBI:58467
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
initial concentration: 1.0

metaM 4abut m
type: Species
is: C00334
name: 4-Aminobutanoate
is: SBO:0000247
boundary condition: false
is: HMDB00112
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
has only substance units: false
initial concentration: 1.0
is: CHEBI:16865
initial amount: NaN
constant: false

metaR AG13T11g
fast: false
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR FACOAL1813
is described by: ECO:0000269
reversible: true
name: fatty-acid--CoA ligase
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3

metaR LPS3e
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.1.3
fast: false
is: SBO:0000176
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
reversible: false
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
name: lipase, extracellular

http://identifiers.org/biomodels.db/MODEL1310110006#_4caf2a69_81b7_4ab8_8140_ce55a33f9350
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q9C0J1
constant: false
name: B3GNT4
is encoded by: hsa:79369

http://identifiers.org/biomodels.db/MODEL1310110006#_6291f1f4_9fcf_4d19_9d8a_f61f8647091f
name: SDHC
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:6391
is: Q99643
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_de42484e_a4d9_48f3_8d60_5ffce476c4b5
name: CHKA
is encoded by: hsa:1119
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaM itp e
name: ITP(3-)
has only substance units: false
is: CHEBI:57614
type: Species
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_49202689_0c0f_4104_894f_0e6e26337212
type: Species
constant: false
initial concentration: NaN
name: _AA081045_1_e
initial amount: NaN
is encoded by: hsa:AA081045
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR r0287
fast: false
is described by: ECO:0000000
product: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
reversible: false
reactant: MODEL1310110006#
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110006#_4b25e79c_8fd6_497c_8e00_83d5d455c23a
type: Species
is encoded by: hsa:NM 001929
constant: false
name: _NM_001929_1_c
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM biocyt m
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: C05552
is: http://identifiers.org/pubchem.compound/7886
type: Species
is: HMDB03134
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
name: Biocytin
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_0d59c5e9_a00c_45d2_a1e3_c9835ad44af8
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: FTCD
is encoded by: hsa:10841
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_38a0ee05_5e4a_419a_abde_ac2fb07fb01e
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
name: GPX6
is encoded by: hsa:257202
constant: false
is: P59796
is: SBO:0000252

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaM mi145p c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01498
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
type: Species
boundary condition: false
is: CHEBI:203600
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245

http://identifiers.org/biomodels.db/MODEL1310110006#_21aa19b6_ecec_4c1d_a109_b3f47fd696e2
is: SBO:0000252
is encoded by: hsa:4717
boundary condition: true
initial concentration: NaN
is: O43677
initial amount: NaN
has only substance units: false
name: NDUFC1
constant: false
type: Species

metaM naglc2p L c
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:18278
has only substance units: false
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
boundary condition: false
constant: false

metaM 2docopencoa m
initial amount: NaN
name: 2,7,10,13,16-docosapentenoylcoa
boundary condition: false
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
has only substance units: false

metaM 3octdece1coa c
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
is: SBO:0000247
boundary condition: false
name: 3-hydroxyoctadecenoylcoa
is: HMDB13336

metaR 2HBO
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
fast: false
is: SBO:0000176
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.27
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000269

metaR SCP2x
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.176
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways version 2 analog added as per KEGG NJ
is described by: ECO:0000269
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000176
name: peroxisomal thiolase 2
reactant: MODEL1310110006#

metaR FAOXC204C184m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaR r1998
product: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110006#
is described by: ECO:0000000
modifier: MODEL1310110006#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR AG13T7g
is described by: ECO:0000000
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110006#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
fast: false
product: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#

metaM 4mzym int2 r
boundary condition: false
is: HMDB06838
has only substance units: false
name: 4-Methylzymosterol intermediate 2
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C28H44O CHARGE: 0 INCHI: InChI=1/C28H44O/c1-18(2)8-7-9-19(3)22-12-13-24-21-10-11-23-20(4)26(29)15-17-28(23,6)25(21)14-16-27(22,24)5/h8,19-20,22-24H,7,9-17H2,1-6H3/t19-,20?,22?,23?,24?,27-,28+/m1/s1

metaM 3snpyr m
is: SBO:0000247
name: 3-Sulfinopyruvate
constant: false
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
is: HMDB02332
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:1665

metaM crm hs g
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:52639
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
name: N-acylsphingosine
is: SBO:0000247

metaM dcsptn1 c
boundary condition: false
is: http://identifiers.org/pubchem.compound/5282848
name: docosa-4,7,10,13,16-pentaenoic acid
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB13123
constant: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial amount: NaN
is: SBO:0000247

metaR UMPK3n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110006#
reversible: true
is described by: ECO:0000269
product: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
fast: false
name: UMP kinase (UTP),nuclear
reactant: MODEL1310110006#

metaR EX 3tetd7ecoacrn
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy tetradecenoyl-7-carnitine
type: Reaction

metaR HDCAtr
type: Reaction
kinetic law: MODEL1310110006#
name: fatty acid transport via diffusion
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaM coa x
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
has only substance units: false
is: CHEBI:57287
initial concentration: 1.0
constant: false
name: Coenzyme A
is: HMDB01423
is: SBO:0000247
is: C00010
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_6fa16171_6f9d_421b_a4e6_1dc0c7a0f0e3
is: P27708
name: CAD
type: Species
is encoded by: hsa:790
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

metaR RE1530C
name: RE1530
kinetic law: MODEL1310110006#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110006#
reactant: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
is described by: ECO:0000000

metaR PGI
modifier: MODEL1310110006#
fast: false
product: MODEL1310110006#
reactant: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:
kinetic law: MODEL1310110006#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.1.9
is: SBO:0000176
type: Reaction
name: glucose-6-phosphate isomerase

metaM glcur l
type: Species
initial concentration: 1.0
is: HMDB00127
has only substance units: false
is: CHEBI:15748
name: D-glucuronate
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
constant: false

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_72d718a6_8189_4191_99a3_6c310628b761
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:51703
is: Q9ULC5
name: ACSL5
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_3f5dff29_6e44_4b61_b90f_8a973ab4a1b5
is: Q9UBM1
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:10400
initial concentration: NaN
name: PEMT

metaR RE1521M
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110006#
fast: false
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1521
reversible: true
is described by: ECO:0000000
is: SBO:0000176

metaR LNELDCCRNt
product: MODEL1310110006#
is: SBO:0000185
name: transport into the mitochondria (carnitine)
reversible: false
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM ach e
name: acetylcholine
constant: false
type: Species
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00895
is: SBO:0000247
is: CHEBI:15355
boundary condition: false

metaM HC01231 c
constant: false
initial concentration: 1.0
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: CHEBI:58480
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate

http://identifiers.org/biomodels.db/MODEL1310110006#_bc79383d_0567_4490_bd95_332121a12044
has only substance units: false
is encoded by: hsa:AI924226
boundary condition: true
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: _AI924226_1_m

metaR SUCCtp
product: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110006#
name: succinate transporter, peroxisome

metaM tdcoa x
has only substance units: false
is: CHEBI:57385
type: Species
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01521
is: C02593
initial amount: NaN
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_72f20b48_31cc_400e_8bd5_77177b1c127c
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:27124
initial amount: NaN
name: INPP5J

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR r0317
product: MODEL1310110006#
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
fast: false
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.8.1.4
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is version of: http://identifiers.org/ec-code/2.1.2.10
reactant: MODEL1310110006#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.4.2

metaM ac m
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
is: HMDB00042
boundary condition: false
is: SBO:0000247
is: CHEBI:30089
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false
name: acetate

metaR TAGt
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: triacylglycerol transport
is: SBO:0000185
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_c02e3bd2_a075_4961_9630_582fe216afd8
type: Species
boundary condition: true
initial amount: NaN
name: ALG8
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:79053
constant: false

metaM galthcrm hs g
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:26174
boundary condition: false
constant: false
name: Gal-Gal-Gal-Glc-Cer
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C42H76NO22FULLRCO CHARGE: 0

metaR M1316Mg
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000000
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.114
reactant: MODEL1310110006#
product: MODEL1310110006#
fast: false

metaR TCYNTt
reversible: false
name: Thiocyanate transport via diffusion (cytosol to extracellular)
reactant: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
kinetic law: MODEL1310110006#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_e
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:15347
constant: false
name: Type IIIA glycolipid
has only substance units: false
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
is: HMDB01659
initial amount: NaN

metaR SUCOASm
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.2.1.5
fast: false
name: Succinate--CoA ligase (ADP-forming)
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.2.1.4
reversible: true
is described by: ECO:0000000

metaR C160CPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110006#
name: production of Palmitoylcarnitine
kinetic law: MODEL1310110006#
type: Reaction
reversible: false
fast: false

metaR FAOXC103C102m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaM nh4 m
name: Ammonium
is: C01342
type: Species
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00051
is: CHEBI:28938
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_38f1bace_ee47_4a5c_b40f_7e3b39394fdb
is: SBO:0000252
is: Q969I6
constant: false
name: SLC38A4
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:55089
initial concentration: NaN
boundary condition: true

metaR ASPTA
kinetic law: MODEL1310110006#
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: true
modifier: MODEL1310110006#
name: aspartate transaminase
reactant: MODEL1310110006#
is: SBO:0000176

metaM itaccoa m
is: HMDB03377
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
has only substance units: false
boundary condition: false
name: itaconyl-CoA(5-)
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57381

http://identifiers.org/biomodels.db/MODEL1310110006#_f85bf946_5f8c_4bff_ab62_cbf792be43bb
is encoded by: hsa:4712
is: SBO:0000252
name: NDUFB6
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: O95139

http://identifiers.org/biomodels.db/MODEL1310110006#_32ce0861_9225_4ba9_b86b_db5f768b558a
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:57835
constant: false
name: SLC4A5
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: Q9BY07

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaR S4TASE1ly
type: Reaction
name: N-acetylgalactosamine-4-sulfatase, lysosomal
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.6.12
reactant: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110006#

metaR 3AIBt
reversible: false
fast: false
product: MODEL1310110006#
name: 3-amino-isobutyrate transport
reactant: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT

metaM phe L c
is: HMDB00159
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17295
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
constant: false
initial concentration: 1.0
name: L-phenylalanine
type: Species
has only substance units: false

metaR CMPSASn
reactant: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.43
reversible: false
kinetic law: MODEL1310110006#
is described by: ECO:0000304
name: CMP sialic acid synthase, nuclear
modifier: MODEL1310110006#
product: MODEL1310110006#
type: Reaction

metaR NACHEX15ly
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110006#
fast: false
modifier: MODEL1310110006#
reversible: false
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110006#
is described by: ECO:0000000

metaM CE5867 e
boundary condition: false
type: Species
notes: FORMULA: C20H32N5O9 CHARGE: -1 INCHI: InChI=1/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)/p-1/t12-,13+,14-,15-/m0/s1 EHMN_ABBREVIATION: CE5867
initial amount: NaN
has only substance units: false
is: HMDB02710
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27485
name: N-acetyl-seryl-aspartyl-lysyl-proline

metaR BTNt4i
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
name: Biotin uptake (antiport)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_434677ca_a273_4aba_8766_afaac8a335be
boundary condition: true
has only substance units: false
is: SBO:0000252
is: B4DG68
is encoded by: hsa:4842
constant: false
type: Species
name: NOS1
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_a38e243c_241b_44cd_95c2_27c23ea7f711
is encoded by: hsa:3291
initial amount: NaN
type: Species
constant: false
name: HSD11B2
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P80365
initial concentration: NaN

metaR r2393
is: SBO:0000185
product: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110006#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_41759268_9985_471c_b7cb_a98a96cfed6c
has only substance units: false
initial amount: NaN
name: GK
constant: false
initial concentration: NaN
is encoded by: hsa:2710
is: B4DH54
boundary condition: true
type: Species
is: SBO:0000252

metaM cs e deg1 l
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
has only substance units: false
is: SBO:0000247
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
initial amount: NaN
boundary condition: false
is: HMDB00868
constant: false
type: Species
is: CHEBI:57737

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_g
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: Type IIIA glycolipid
boundary condition: false
is: HMDB00304
type: Species
constant: false
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
is: CHEBI:57847
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_470cd61c_7fd5_4ab9_b686_816d090853de
type: Species
name: UAP1
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:6675
has only substance units: false
is: Q16222
boundary condition: true
is: SBO:0000252

metaR r0022
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.8.1.7
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_1454fa3a_cf24_403a_a741_a0916d148ffd
is: SBO:0000252
is encoded by: hsa:5831
is: P32322
initial concentration: NaN
has only substance units: false
name: PYCR1
boundary condition: true
constant: false
type: Species
initial amount: NaN

metaM idp n
initial concentration: 1.0
is: HMDB03335
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: CHEBI:58280
name: IDP(3-)
has only substance units: false
is: SBO:0000247
type: Species

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR NRPPHRSULT
reactant: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.1
name: Norepinephrine Sulfotransferase
fast: false
notes: GENE_ASSOCIATION: (6818.1) or (6818.3) or (6818.2) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)
kinetic law: MODEL1310110006#
product: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269

metaM ksii core2 deg4 l
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57455
name: keratan sulfate II (core 2-linked), degradation product 4
is: HMDB01354
type: Species
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C58H95N5O43SX CHARGE: -1

metaR r0021
fast: false
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
reversible: true
is: SBO:0000176
modifier: MODEL1310110006#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5

metaM phe L e
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
initial amount: NaN
is: HMDB00159
is: CHEBI:17295
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
name: L-phenylalanine

metaR HGNTOR
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.5
reversible: false
type: Reaction
product: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:

metaR r1945
kinetic law: MODEL1310110006#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110006#
reversible: false
reactant: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_520909c0_3e6c_42ee_a0f5_ee730c3ef850
initial amount: NaN
name: HADHB
is: P55084
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:3032
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_cc4c2fc5_5dc3_4882_b835_cca82a7461ac
type: Species
constant: false
name: _AI378339_1_m
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI378339

http://identifiers.org/biomodels.db/MODEL1310110006#_89529e72_b8bb_4dc6_b223_fa4873de1fec
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: PDE8A
is encoded by: hsa:5151
constant: false
type: Species

metaR PNTOt5
modifier: MODEL1310110006#
type: Reaction
is: SBO:0000185
product: MODEL1310110006#
reactant: MODEL1310110006#
reversible: false
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (8884.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10329687,PMID:10334869,PMID:12646417,PMID:15561972,PMID:9516450 NOTES:_01-25-05 based on Wang et al., JBC, 1999,1 274(21), 14875-14888. IT 03-07-05:replaced IT: now based on Balamurugan et al, 2005, Am J Physiol Renal Physiol, 288, F823-831,2005
name: Pantothenate sodium symporter II

metaR FAOXC102C103x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

metaR INSTt4
name: inositol transport via sodium symport
is described by: ECO:0000269
is: SBO:0000185
fast: false
reactant: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
reversible: true
type: Reaction

metaR G14T12g
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176

metaM HC01223 m
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
initial amount: NaN
is: CHEBI:57340
has only substance units: false
constant: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_09fbfd83_4f1d_41cb_99e3_3a1a29eae3d8
is encoded by: hsa:5137
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: PDE1C
is: Q8NB10
boundary condition: true
type: Species

metaR r1964
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: false
reactant: MODEL1310110006#

metaM pro L m
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: SBO:0000247
boundary condition: false
is: CHEBI:17203
name: L-proline
is: HMDB00162
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN

metaR FAOXC80
is described by: ECO:0000269
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
name: Beta oxidation of med/long chain fatty acid
modifier: MODEL1310110006#
reversible: false
is: SBO:0000176
reactant: MODEL1310110006#

metaR r2395
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110006#
reversible: false
product: MODEL1310110006#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110006#
is: SBO:0000185

metaM 5tedtricoa m
is: HMDB02288
type: Species
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
has only substance units: false
name: 5,8,11-tetradecatrienoylcoa
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

metaR FAOXC15C13m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

metaM tetpent6coa c
name: tetracosapentaenoyl coenzyme A, n-6
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
is: C16172
constant: false
is: SBO:0000247
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1

metaR H4ETer
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110006#
is: SBO:0000176
name: H4 phosphoethanolaminyl transferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
reactant: MODEL1310110006#
product: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
reversible: false

metaR DM pe hs LPAREN r RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pe_hs[r]
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_09c60186_33fd_438f_89c6_69aceae79109
is encoded by: hsa:377841
is: Q5MY95
name: ENTPD8
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: false

metaM core2 g
boundary condition: false
is: CHEBI:15876
initial amount: NaN
is: SBO:0000247
name: Core 2
initial concentration: 1.0
notes: FORMULA: C22H37N2O15X CHARGE: 0
type: Species
constant: false
has only substance units: false

metaR NTD11
modifier: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
reversible: false
reactant: MODEL1310110006#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
fast: false
is: SBO:0000176
name: 5'-nucleotidase (IMP)
is version of: http://identifiers.org/ec-code/3.1.3.5

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaM glyald c
boundary condition: false
constant: false
is: C00577
initial concentration: 1.0
type: Species
is: CHEBI:17378
is: SBO:0000247
is: HMDB01051
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
name: D-Glyceraldehyde
has only substance units: false

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR BACCL
modifier: MODEL1310110006#
is described by: ECO:0000269
product: MODEL1310110006#
reversible: false
reactant: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: 6.3.4.15 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7842009 NOTES:IT
type: Reaction
name: biotin-[acetyl-CoA-carboxylase] ligase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110006#

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaM ptrc e
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:326268
boundary condition: false
is: HMDB01414
type: Species
name: Putrescine
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
initial amount: NaN
is: SBO:0000247
is: C00134

metaM arachdcoa c
initial concentration: 1.0
name: arachidonoyl-CoA(4-)
constant: false
is: HMDB06523
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368

http://identifiers.org/biomodels.db/MODEL1310110006#_aa992c93_beed_4699_9ad2_e654659bd7d9
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:8897
type: Species
is: SBO:0000252
name: MTMR3
is: Q13615
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_3d885426_c9a8_436d_957a_60e1c9ee94fa
is encoded by: hsa:37
boundary condition: true
type: Species
initial concentration: NaN
name: ACADVL
is: P49748
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_a8538433_fca7_41c5_b5d8_038761441cc3
has only substance units: false
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
name: B3GALT5
boundary condition: true
is encoded by: hsa:10317

metaR CRNCARtp
name: carnitine-acetylcarnitine carrier, peroxisomal
product: MODEL1310110006#
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_56586211_a68a_4d93_8c2a_a2cfc6ecd29a
constant: false
is encoded by: hsa:206358
has only substance units: false
boundary condition: true
type: Species
name: SLC36A1
is: Q1LZ56
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM eitetcoa x
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/24892790
constant: false
initial amount: NaN
name: 5,8,11,14-eicosatetraenoylcoa
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaM xol25oh r
initial amount: NaN
has only substance units: false
name: 25-hydroxycholesterol
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
is: CHEBI:42977
initial concentration: 1.0
is: HMDB06247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_e8df6733_3f60_457a_9e44_4c2fc8db7198
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2752
has only substance units: false
constant: false
is: P15104
name: GLUL

metaM 4hexdtricoa m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
name: 4,7,10-hexadecatrienoylcoa
constant: false
is: HMDB02288
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_galacgalfuc12gal14acglcgalgluside_hs_g
boundary condition: false
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
initial amount: NaN
constant: false
is: CHEBI:26174
type: Species

metaR ADA
is: SBO:0000176
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
is version of: http://identifiers.org/ec-code/3.5.4.4
modifier: MODEL1310110006#
name: Adenosine deaminase
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110006#
reversible: false
fast: false

metaR BILIRUBtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110006#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#

metaM CE2424 m
constant: false
is: CHEBI:28387
boundary condition: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
type: Species
has only substance units: false
is: HMDB11123
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR PRODt2r
product: MODEL1310110006#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
type: Reaction
name: D-proline reversible transport via proton symport
is described by: ECO:0000304

metaM amet c
is: HMDB01185
name: S-Adenosyl-L-methionine
boundary condition: false
has only substance units: false
is: CHEBI:15414
initial amount: NaN
constant: false
is: C00019
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019

http://identifiers.org/biomodels.db/MODEL1310110006#_11fbca2e_a9cc_4fce_964e_2d645f4b7808
constant: false
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: B7Z2M9
is encoded by: hsa:8525
initial amount: NaN
is: SBO:0000252
name: DGKZ

metaM mag hs e
is: HMDB03073
initial concentration: 1.0
is: CHEBI:32391
constant: false
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: monoacylglycerol 2
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_40d4ed0d_32db_4a54_acd4_919c1d898e1f
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: P38571
is: SBO:0000252
is encoded by: hsa:3988
constant: false
name: LIPA

http://identifiers.org/biomodels.db/MODEL1310110006#_b10d196b_d5d0_4e0e_ad5d_346e0d7a19fa
has only substance units: false
constant: false
is: O94777
is encoded by: hsa:8818
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
name: DPM2

http://identifiers.org/biomodels.db/MODEL1310110006#_3b3f02c7_27d6_4c71_b46f_f09d7602ef1a
initial amount: NaN
constant: false
boundary condition: true
name: NDUFA13
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: Q9P0J0
is encoded by: hsa:51079

http://identifiers.org/biomodels.db/MODEL1310110006#_5b66df9f_54ef_4218_aab3_7bd656b551a7
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:4694
name: NDUFA1
is: Q6IBB5
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_726eb063_64be_4948_a931_f49b2d3b5aea
boundary condition: true
is: Q1ET61
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6818
type: Species
is: SBO:0000252
name: SULT1A3
constant: false
has only substance units: false

metaR PROD2m
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
is version of: http://identifiers.org/ec-code/1.5.99.8
is described by: ECO:0000254
type: Reaction
modifier: MODEL1310110006#
name: Proline dehydrogenase (m)
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: false
reactant: MODEL1310110006#
fast: false
is: SBO:0000176

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM cholp c
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
name: choline phosphate(1-)
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:295975
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_faca1783_7bf0_4e77_bf76_ee1054ccca54
name: GGH
has only substance units: false
is encoded by: hsa:8836
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
boundary condition: true
is: Q92820
is: SBO:0000252

metaM hexc c
is: SBO:0000247
is: CHEBI:31013
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
boundary condition: false
type: Species
is: HMDB02356
name: cerotate
constant: false
initial amount: NaN

metaR r0157
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
modifier: MODEL1310110006#
reversible: false
fast: false
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.3.4.2
product: MODEL1310110006#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
kinetic law: MODEL1310110006#
is: SBO:0000176

metaR ALAGLYexR
is described by: ECO:0000304
fast: false
reversible: true
is: SBO:0000185
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
name: L-alanine/glycine reversible exchange

http://identifiers.org/biomodels.db/MODEL1310110006#_0889222a_1930_4790_b87e_ce45ed30c8c0
type: Species
is: SBO:0000252
initial concentration: NaN
name: PRDX2
is encoded by: hsa:7001
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_731a2c02_37cd_437b_b964_afa5c711ee4e
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:FLJ44968
name: _FLJ44968_1_m
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_a169c144_ecf3_4f26_8fa1_fcaabf22d412
name: SLC13A1
is: Q9BZW2
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:6561
boundary condition: true
type: Species

metaM 5dpmev c
has only substance units: false
initial concentration: 1.0
name: (R)-5-Diphosphomevalonate
is: HMDB01090
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1

metaM pheme e
initial amount: NaN
is: HMDB03178
name: Protoheme
is: C00032
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:17627
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
has only substance units: false

metaM eitetcoa m
has only substance units: false
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
name: 5,8,11,14-eicosatetraenoylcoa
is: http://identifiers.org/pubchem.compound/24892790

metaR r0706
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
fast: false
product: MODEL1310110006#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.99.10
is: SBO:0000176
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

metaM 6pgl r
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
constant: false
is: SBO:0000247
type: Species
is: HMDB01127
has only substance units: false
initial concentration: 1.0
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
boundary condition: false
is: CHEBI:57955
initial amount: NaN

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_92cc3f48_85e0_4bda_9a66_9ac9f28e303e
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is encoded by: hsa:3030
initial concentration: NaN
initial amount: NaN
name: HADHA
is: E9KL44
boundary condition: true

metaR r0156
type: Reaction
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.1.40
reversible: false
product: MODEL1310110006#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is: SBO:0000176
is described by: ECO:0000000

metaR GCC2bim
kinetic law: MODEL1310110006#
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10
is described by: ECO:0000269
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.4.2
is: SBO:0000176
product: MODEL1310110006#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110006#

metaR r1400
type: Reaction
is: SBO:0000185
name: Active transport
reactant: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
fast: false

metaR ACGBGBSIDEtl
reactant: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
name: acgbgbside hs intracellular transport
fast: false
reversible: true
kinetic law: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110006#

metaM thmmp c
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
initial amount: NaN
constant: false
type: Species
is: CHEBI:37575
initial concentration: 1.0
has only substance units: false
name: Thiamin monophosphate
is: C01081
boundary condition: false
is: SBO:0000247
is: HMDB02666

metaR A MANASEly
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
name: alpha-mannosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.24
type: Reaction
fast: false
product: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110006#

metaR r1682
type: Reaction
reactant: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110006#
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110006#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110006#_a9b292dc_ee0a_4ad9_b521_f09419d76696
initial amount: NaN
name: CTSA
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P10619
has only substance units: false
is encoded by: hsa:5476
type: Species
constant: false

metaM pro L c
type: Species
is: CHEBI:17203
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00162
has only substance units: false
constant: false
name: L-proline

metaR r1538
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000000
product: MODEL1310110006#
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
reactant: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reversible: false

metaR r1401
type: Reaction
reactant: MODEL1310110006#
fast: false
modifier: MODEL1310110006#
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.1.1.3
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.41
is: SBO:0000185
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.35
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.51
reversible: false
is version of: http://identifiers.org/ec-code/2.7.10.1
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:

metaM lgnccoa x
has only substance units: false
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
name: lignocericyl coenzyme A
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB06526
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_10ce8a6b_db7d_4605_9ac9_45db1cbad76a
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: Q8NEB9
type: Species
boundary condition: true
name: PIK3C3
is encoded by: hsa:5289

metaR r1683
product: MODEL1310110006#
modifier: MODEL1310110006#
name: Y+LAT2 Utilized transport
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#

metaR MM7Cbg
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.113
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
modifier: MODEL1310110006#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
type: Reaction
reversible: false

metaR 3MOPt2im
reversible: false
is: SBO:0000185
reactant: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
fast: false
kinetic law: MODEL1310110006#

metaM pheme c
name: Protoheme
initial amount: NaN
is: HMDB03178
is: C00032
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:17627

http://identifiers.org/biomodels.db/MODEL1310110006#_9be95f75_1188_4782_bf24_ab073f068c14
name: NME1:NME2
initial amount: NaN
is encoded by: hsa:4831
has part: P15531
initial concentration: NaN
has part: P22392
constant: false
has only substance units: false
is encoded by: hsa:4830
is: SBO:0000297
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_e76e6266_72b0_462c_8af4_0a9bda4d429d
name: ALDH9A1
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is: P49189
is encoded by: hsa:223
type: Species

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaR S6T10g
kinetic law: MODEL1310110006#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
product: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
modifier: MODEL1310110006#

metaM cholp g
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
name: choline phosphate(1-)
type: Species
constant: false
has only substance units: false
is: CHEBI:295975
is: C00588

http://identifiers.org/biomodels.db/MODEL1310110006#_8f5897cd_635a_43c7_921c_10080cd74b07
name: ETFB
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:2109
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_82a2a9df_a7b4_4711_81c1_cd910d13fc2b
boundary condition: true
is: Q8TDY1
constant: false
name: B3GALNT1
is encoded by: hsa:8706
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_4ab16a2a_f9b3_4faf_9458_b72c5e593ffc
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:4597
is: P53602
constant: false
has only substance units: false
is: SBO:0000252
name: MVD

metaM cs e deg6 l
notes: FORMULA: C31H48NO32S2 CHARGE: -3
is: HMDB01354
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:57455
boundary condition: false
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 6

http://identifiers.org/biomodels.db/MODEL1310110006#_d87afafb_429f_4105_a70e_c798655e2a99
initial concentration: NaN
is encoded by: hsa:6799
name: SULT1A2
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false

metaR RE3301C
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.4
kinetic law: MODEL1310110006#
product: MODEL1310110006#
name: RE3301
type: Reaction
modifier: MODEL1310110006#
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_e28753d6_ccb4_4f7e_9578_809c1dfd8a6d
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10195
initial amount: NaN
name: ALG3
constant: false
boundary condition: true
type: Species
initial concentration: NaN

metaM pro L e
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
constant: false
name: L-proline
boundary condition: false
is: HMDB00162
is: SBO:0000247

metaM triodthy e
constant: false
is: HMDB00265
boundary condition: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial amount: NaN
type: Species
name: 3,3',5-triiodo-L-thyronine
has only substance units: false
is: CHEBI:18258
initial concentration: 1.0
is: SBO:0000247

metaM taur x
is: SBO:0000247
has only substance units: false
is: CHEBI:15891
name: taurine
initial concentration: 1.0
constant: false
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00251

http://identifiers.org/biomodels.db/MODEL1310110006#_eeead2f8_8455_4009_8bde_0162a7dc47ed
initial concentration: NaN
is encoded by: hsa:8854
name: ALDH1A2
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is: B4DZR2
constant: false
initial amount: NaN

metaR TYRt
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110006#
modifier: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
name: L-tyrosine transport
kinetic law: MODEL1310110006#

metaM tetpent6 e
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
name: tetracosapentaenoic acid, n-6
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
is: HMDB06322
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_5231e10f_8814_40fa_ae04_94a8935416e1
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
name: MTHFD1L
initial concentration: NaN
is: B2RD24
is encoded by: hsa:25902
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_d1bec651_0602_434c_8228_8560acd30dc9
is encoded by: hsa:5152
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PDE9A
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_87444381_0069_4e2e_a29f_6a33e5ed8e90
boundary condition: true
is encoded by: hsa:11112
initial concentration: NaN
initial amount: NaN
is: P31937
constant: false
is: SBO:0000252
name: HIBADH
type: Species
has only substance units: false

metaM ump c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00288
has only substance units: false
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
type: Species
is: CHEBI:57865
name: UMP
is: C00105

metaR 3HCO3 NAt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
product: MODEL1310110006#
fast: false
name: 3HCO3_NAt
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaM 5htrp c
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB00472
has only substance units: false
is: CHEBI:17780
type: Species
name: 5-hydroxy-L-tryptophan
boundary condition: false
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643

metaR SUBERCACT
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

metaM ksi pre9 g
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
initial concentration: 1.0
constant: false
is: HMDB00175
type: Species
is: CHEBI:58053
has only substance units: false
is: C00130
name: keratan sulfate I biosynthesis, precursor 9
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_683f2e41_f86c_4f43_9709_d7327ab215e0
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:4696
is: O95167
initial concentration: NaN
has only substance units: false
boundary condition: true
name: NDUFA3

metaR S6TASE20ly
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176

metaM dump n
is: HMDB01409
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: dUMP(2-)
initial amount: NaN
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
has only substance units: false
is: CHEBI:246422

metaM dmnoncrn c
name: 4,8-dimethylnonanoyl carnitine
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
constant: false
has only substance units: false
notes: FORMULA: C18H37NO4 CHARGE: 0
initial concentration: 1.0
is: HMDB06202

http://identifiers.org/biomodels.db/MODEL1310110006#_d1a4e061_7146_48fc_b70d_092e2ba6be0d
is: Q6IBA0
type: Species
name: NDUFS5
initial amount: NaN
is encoded by: hsa:4725
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_c
is: HMDB01659
type: Species
constant: false
is: CHEBI:15347
boundary condition: false
has only substance units: false
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
is: SBO:0000247
name: Type IIIA glycolipid
initial amount: NaN
initial concentration: 1.0

metaM frdp x
name: farnesyl pyrophosphate(3-)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00961
constant: false
type: Species
is: CHEBI:175763
boundary condition: false
initial amount: NaN
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448

metaR PTPAT
fast: false
name: Phosphopantetheine adenylyltransferase (EC 2.7.7.3)
reactant: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
is: SBO:0000176
product: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.3
is described by: ECO:0000269
type: Reaction

metaM mag hs c
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:16521
name: monoacylglycerol 2
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB01251
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_a19d5e0b_846d_465f_827f_0ce86f8efe83
is encoded by: hsa:4697
type: Species
name: NDUFA4
is: O00483
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaR DOLDPP Ler
name: Dolichyl-diphosphate phosphohydrolase, human (liver)
reactant: MODEL1310110006#
modifier: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.43
product: MODEL1310110006#

metaM triodthy c
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: SBO:0000247
name: 3,3',5-triiodo-L-thyronine
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00265
is: CHEBI:18258

http://identifiers.org/biomodels.db/MODEL1310110006#_d9a5e1d9_680d_4bbb_9a4b_26b9c77e0cd6
is: SBO:0000252
name: NME1
is encoded by: hsa:4830
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM ksi deg33 l
is: HMDB00143
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:12936
initial concentration: 1.0
constant: false
name: keratan sulfate I, degradation product 33
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
is: SBO:0000247
boundary condition: false

metaM glyald m
type: Species
is: CHEBI:17378
initial amount: NaN
is: SBO:0000247
constant: false
name: D-glyceraldehyde
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial concentration: 1.0
boundary condition: false
is: HMDB01051
has only substance units: false

metaM nh4 n
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
name: ammonium
initial concentration: 1.0
is: HMDB00051
has only substance units: false

metaM xolest2 hs e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
is: CHEBI:17002
type: Species
initial amount: NaN
constant: false
name: cholesterol ester

metaR ACONTm
type: Reaction
product: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
reversible: true
name: Aconitate hydratase
is version of: http://identifiers.org/ec-code/4.2.1.3
fast: false
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110006#
reactant: MODEL1310110006#

metaM dump m
initial concentration: 1.0
has only substance units: false
is: CHEBI:246422
initial amount: NaN
is: HMDB01409
constant: false
type: Species
name: dUMP(2-)
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: SBO:0000247
boundary condition: false

metaM ksi deg20 l
constant: false
name: keratan sulfate I, degradation product 20
is: SBO:0000247
type: Species
is: CHEBI:12936
initial concentration: 1.0
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
boundary condition: false
is: HMDB00143
initial amount: NaN
has only substance units: false

metaM tetpent6 c
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB06322
has only substance units: false
constant: false
name: tetracosapentaenoic acid, n-6
is: SBO:0000247

metaM glygn4 e
is: HMDB00122
is: CHEBI:4167
boundary condition: false
is: SBO:0000247
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C18H31O16X CHARGE: 0

metaR FAOXC103C102x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

metaR SPHMDAc
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12069827 NOTES:limited details on mechanism, localization, etc. See PMID: 12069827 NJ
kinetic law: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110006#
name: sphingomyelin deacylase
product: MODEL1310110006#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_93dedcad_b8b3_4483_b2dd_d29e529c34c3
is: SBO:0000252
initial amount: NaN
is: P14324
boundary condition: true
initial concentration: NaN
name: FDPS
constant: false
type: Species
is encoded by: hsa:2224
has only substance units: false

metaM dhcholestanate c
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: HMDB00359
initial concentration: 1.0
constant: false
is: CHEBI:16577
boundary condition: false
type: Species

metaR GLYt7 211 r
reactant: MODEL1310110006#
is described by: ECO:0000269
name: glycine reversible transport via sodium and chloride symport (2:1:1)
kinetic law: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
product: MODEL1310110006#

metaM xol27oh r
has only substance units: false
name: 26-hydroxycholesterol
initial amount: NaN
is: CHEBI:17703
is: HMDB02103
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340

metaR DAG HSter
reactant: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
reversible: false
is: SBO:0000185
name: diacylglycerol ER export
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110006#_ab518dd2_9f03_49ed_9615_8c78611a1a4b
has only substance units: false
initial amount: NaN
name: ENTPD2
constant: false
type: Species
is: SBO:0000252
is: Q5SPY7
boundary condition: true
is encoded by: hsa:954
initial concentration: NaN

metaR GCHOLAt2
reversible: false
fast: false
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (6554.1) or (6555.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12851823,PMID:7592981,PMID:8132774,PMID:9109432 NOTES:electrogenic uptake NJ
product: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
name: glycocholate transport via sodium cotransport

http://identifiers.org/biomodels.db/MODEL1310110006#_8afbbce0_a5ba_43be_9b70_19f3bb6cab04
is: Q9NSW9
type: Species
is: SBO:0000252
is encoded by: hsa:6553
boundary condition: true
initial concentration: NaN
name: SLC9A5
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_6afbaf7f_920f_497f_9cce_c533f0ac7d08
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:276
type: Species
name: AMY1A
is: Q6NSB3
boundary condition: true
has only substance units: false

metaR HSPGtly
name: heparan sulfate transport, extracellular to lysosome
is described by: ECO:0000000
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110006#
is: SBO:0000185
fast: false
type: Reaction
reversible: false
product: MODEL1310110006#

metaR KYNATESYN
fast: false
product: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
type: Reaction
reversible: false

metaR r0160
modifier: MODEL1310110006#
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
reversible: false
kinetic law: MODEL1310110006#
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
type: Reaction
product: MODEL1310110006#
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.1.3.2

metaM ump g
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
has only substance units: false
type: Species
is: CHEBI:57865
initial amount: NaN
is: HMDB00288
boundary condition: false
initial concentration: 1.0
name: UMP(2-)
constant: false
is: SBO:0000247

metaM Rtotal3 e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: CO2FULLR3 CHARGE: -1
constant: false
is: CHEBI:3554
is: SBO:0000247
name: R total 3 position
type: Species
is: HMDB00244
has only substance units: false
boundary condition: false
is: C00255

http://identifiers.org/biomodels.db/MODEL1310110006#_2120d79e_f70a_4b48_865f_5b4e440ef2c8
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:4832
boundary condition: true
constant: false
is: Q13232
name: NME3
is: SBO:0000252
type: Species

metaR MTHFD2m
is: SBO:0000176
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
product: MODEL1310110006#
fast: false
modifier: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
is described by: ECO:0000254

metaM dgdp m
is: HMDB00960
initial amount: NaN
type: Species
is: CHEBI:58595
constant: false
name: dGDP(2-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
has only substance units: false

metaM arachdcoa m
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
constant: false
is: SBO:0000247
is: CHEBI:57368
has only substance units: false
is: HMDB06523
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
name: arachidonoyl-CoA(4-)

metaM prostgi2 c
initial concentration: 1.0
is: CHEBI:57403
has only substance units: false
constant: false
name: prostaglandin I2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01335
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_f7b3c293_34ac_413c_9163_0620f208f632
initial amount: NaN
is: SBO:0000252
name: PDE10A
initial concentration: NaN
is encoded by: hsa:10846
constant: false
is: Q9Y233
type: Species
has only substance units: false
boundary condition: true

metaR MAN6PI
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110006#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.1.8
reversible: true
product: MODEL1310110006#
name: mannose-6-phosphate isomerase
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110006#
fast: false

metaM lnlnca c
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
name: alpha-linolenate
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: HMDB01388
constant: false
has only substance units: false
is: CHEBI:32387

metaR r0434
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
product: MODEL1310110006#
reactant: MODEL1310110006#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_3c5b32fc_0a2a_4a80_852e_c363d4e72c8b
name: CHAT
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:1103
is: Q6LEN5

http://identifiers.org/biomodels.db/MODEL1310110006#_10be8c74_80f9_48e9_b6e5_82685aec91d5
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:125061
initial concentration: NaN
name: AFMID
type: Species
initial amount: NaN
is: Q63HM1
has only substance units: false

metaM acgal1p c
is: CHEBI:55404
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB06480
type: Species
is: SBO:0000247
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
name: N-Acetyl-D-galactosamine 1-phosphate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_83b71120_7363_4ee1_bdb8_0e2ce9ca3706
initial concentration: NaN
is: C7ECU1
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ACE2
constant: false
has only substance units: false
is encoded by: hsa:59272

http://identifiers.org/biomodels.db/MODEL1310110006#_acd67e24_85c9_49f4_9407_9d6aba69424c
has only substance units: false
initial amount: NaN
boundary condition: true
name: DOLPP1
is: SBO:0000252
is encoded by: hsa:57171
initial concentration: NaN
type: Species
is: Q86YN1
constant: false

metaM ksi deg17 l
initial amount: NaN
is: CHEBI:12936
is: SBO:0000247
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
type: Species
constant: false
is: HMDB00143
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: keratan sulfate I, degradation product 17

metaR G14Tg
modifier: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000269
fast: false
reactant: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
kinetic law: MODEL1310110006#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90

metaR RAtn3
product: MODEL1310110006#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
name: 13-cis-retinoic acid transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_75e61fad_2e66_411d_8e90_c42582cbcfe2
type: Species
is encoded by: hsa:1890
has only substance units: false
initial concentration: NaN
is: P19971
name: TYMP
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_6bc86252_4ea2_42b7_9f01_31c9afb03a24
type: Species
is: P05187
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ALPP
is encoded by: hsa:250
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_24286e70_fb6a_4a7b_bfe4_b6cc681d6edf
initial amount: NaN
initial concentration: NaN
type: Species
is: P40394
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:131
name: ADH7
is: SBO:0000252

MODEL1310110006#
species: metaM ksii core2 pre2 g
species: metaM ksi pre9 g
species: metaM gsn c
species: metaM lnlnca e
species: metaM sebacid c
species: metaM his L c
species: metaM etfox m
species: metaM sbcoa x
species: metaM lneldc c
species: metaM tettet6 c
species: metaM sarcs e
species: metaM b2coa m
species: metaM g2m8masn r
species: metaM dolmanp U r
species: metaM c226coa c
species: metaM cdp c
stoichiometry: 11.0
species: metaM CE4872 c
species: metaM ppi r
species: metaM HC02202 c
species: metaM 3ddecdicoa m
species: metaM mi13p c
species: metaM 42A3HP24DB c
species: metaM 2docopencoa x
species: metaM 10fthf5glu e
species: metaM HC00695 m
species: metaM L2aadp6sa m
species: metaM ksii core4 pre4 g
species: metaM hs deg5 l
species: metaM din e
stoichiometry: 20.650823
species: metaM sebcoa c
initial concentration: NaN
species: metaM thcholstoic m
species: metaM 2mp2coa m
species: metaM mgacpail hs r
species: metaM CE5788 e
species: metaM gmp c
species: metaM trdrd m
species: metaM ps hs m
species: metaM udp g
species: metaM txa2 e
species: metaM ksii core4 g
species: metaM 2dr1p c
species: metaM 4mzym int2 r
species: metaM 5aop m
species: metaM gpail hs c
species: metaM pail34p hs c
species: metaM lald D c
species: metaM amp x
species: metaM CE2433 m
species: metaM CE5586 c
species: metaM c226coa m
species: metaM sucr e
species: metaM nadh r
species: metaM dtdp n
species: metaM adrncrn c
species: metaM acnam n
species: metaM 4hexdtetcoa m
species: metaM nadh c
species: metaM nadph m
species: metaM 3ddcrn c
species: metaM 34dhmald m
species: metaM ksi e
species: metaM co2 x
species: metaM gthrd e
species: metaM decdicoa c
species: metaM cgly c
species: metaM HC01842 c
species: metaM q10 e
species: metaM spc hs e
species: metaM lgnccoa c
species: metaM dcmp n
species: metaM retinol 9 cis e
species: metaM sphings c
species: metaM pglyc hs e
species: metaM strdnc c
species: metaM paf hs c
species: metaM dhf l
species: metaM Tn antigen l

metaR PI345P3P
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.67
type: Reaction
reversible: false
product: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
modifier: MODEL1310110006#

metaR r0853
reactant: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
fast: false
type: Reaction
product: MODEL1310110006#
name: Facilitated diffusion
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_494f9529_378e_41b5_893a_5243acdecb49
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:W74642
constant: false
name: _W74642_1_c

http://identifiers.org/biomodels.db/MODEL1310110006#_758bed4e_a52f_4274_a10f_e8b31f677be5
boundary condition: true
name: PMM1
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: A8K003
constant: false
is encoded by: hsa:5372
type: Species
has only substance units: false

metaM 2mp2coa m
initial amount: NaN
boundary condition: false
name: 2-Methylprop-2-enoyl-CoA
is: HMDB01011
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
initial concentration: 1.0
type: Species
is: CHEBI:27754

metaR TSTSTERONEtr
name: testosterone intracellular transport
kinetic law: MODEL1310110006#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110006#
reversible: true
product: MODEL1310110006#
is: SBO:0000185

metaM 6thf e
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
constant: false
is: http://identifiers.org/pubchem.compound/169691
type: Species
initial amount: NaN
name: hexaglutamyl folate (THF)

metaM prostgi2 e
is: CHEBI:57403
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
name: prostaglandin I2(1-)
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335
type: Species
constant: false

metaR ASPPROASCT1
reversible: false
reactant: MODEL1310110006#
fast: false
is: SBO:0000185
modifier: MODEL1310110006#
is described by: ECO:0000134
type: Reaction
product: MODEL1310110006#
name: aspartate intake by system ASCT-1 transporter
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.

metaR UAGALDP
product: MODEL1310110006#
name: UDP-N-acetylgalactosamine diphosphorylase
reversible: false
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110006#
fast: false

metaM ump e
name: UMP(2-)
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00288
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_d1ddabd3_863d_4d83_ba1a_d407a6c149bb
constant: false
is: SBO:0000297
initial concentration: NaN
has only substance units: false
boundary condition: true
name: PIK3CA:PIK3R1
has part: P27986
type: Species
is encoded by: hsa:5295
initial amount: NaN

metaM lnlnca e
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
name: alpha-linolenate
is: HMDB01388
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
is: CHEBI:32387
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_30545111_4041_4cc2_b0e5_5e1c1fc26c0a
is: SBO:0000252
constant: false
boundary condition: true
is: P04179
initial concentration: NaN
is encoded by: hsa:6648
name: SOD2
type: Species
initial amount: NaN
has only substance units: false

metaR NADH2 u10m
is version of: http://identifiers.org/ec-code/1.6.5.3
reversible: false
modifier: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000134
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
is version of: http://identifiers.org/ec-code/1.6.99.3
type: Reaction
is: SBO:0000185
fast: false
name: NADH dehydrogenase, mitochondrial

metaM ksii core4 pre2 g
notes: FORMULA: C47H76N4O33X CHARGE: -1
name: keratan sulfate II boisynthesis, precursor 2
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:58053
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C00130
is: HMDB00175

metaM dmnoncrn m
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB06202
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
name: 4,8 dimethylnonanoyl carnitine
type: Species
constant: false

metaR CHATn
product: MODEL1310110006#
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000269
name: Choline O-acetyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.6
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
reactant: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_36212a5d_5161_42bc_9454_cf31866a685d
name: DLD:DLST:OGDH:PDHX
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000297
initial concentration: NaN
has part: B4E3E9
is encoded by: hsa:4967

metaR S6TASE19ly
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
is: SBO:0000176
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
reversible: true
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110006#

metaR APOCF
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
kinetic law: MODEL1310110006#
fast: false
is described by: ECO:0000000
name: Apocarboxylase formation
type: Reaction
reactant: MODEL1310110006#
reversible: false
is: SBO:0000176
product: MODEL1310110006#

metaM xol27oh m
initial concentration: 1.0
name: 26-hydroxycholesterol
boundary condition: false
is: CHEBI:17703
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial amount: NaN

metaR ACGBGBSIDEtg
reversible: true
reactant: MODEL1310110006#
name: acgbgbside hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaR HMGCOASim
fast: false
kinetic law: MODEL1310110006#
name: Hydroxymethylglutaryl CoA synthase (ir)
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.10
product: MODEL1310110006#

metaM ppcoa x
is: CHEBI:57392
has only substance units: false
boundary condition: false
constant: false
name: Propanoyl-CoA
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01275
initial amount: NaN
is: C00100

metaR RE1531M
type: Reaction
fast: false
name: RE1531
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_f85ca580_c137_4e04_b0af_536913fb7bfc
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:6184
is: P04843
name: RPN1
type: Species
initial amount: NaN

metaR FAOXC102C103m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaR RE2972M
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: RE2972
modifier: MODEL1310110006#
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
fast: false
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.1.67

metaM hs l
initial concentration: 1.0
has only substance units: false
name: heparan sulfate, free chain
initial amount: NaN
is: CHEBI:28815
constant: false
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
is: SBO:0000247
boundary condition: false
type: Species

metaR r1690
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110006#
name: Y+LAT2 Utilized transport

metaR r0437
is: SBO:0000176
is described by: ECO:0000000
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
kinetic law: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.1.2.13
product: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false

metaM CE5786 e
is: HMDB02710
is: SBO:0000247
name: kinetensin
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:27485
type: Species
initial amount: NaN
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
constant: false

metaM ei11ecoa x
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
name: 11-eicosenoylcoa
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false

metaR CO2tp
fast: false
kinetic law: MODEL1310110006#
name: CO2 peroxisomal transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110006#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110006#

metaR EX gbside hs LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: globoside (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_65a84c0d_b407_4802_89ce_f656c7276d36
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is: O75610
boundary condition: true
initial amount: NaN
name: LEFTY1
has only substance units: false
is encoded by: hsa:10637

metaM fum m
initial concentration: 1.0
is: C00122
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:29806
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
name: Fumarate
boundary condition: false
is: HMDB00134

http://identifiers.org/biomodels.db/MODEL1310110006#_875674f4_e56b_47c6_8fbb_5e8277c9d5db
constant: false
is: Q6LEN5
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:1103
has only substance units: false
initial amount: NaN
name: CHAT
is: SBO:0000252

metaM thcholoylcoa x
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
initial amount: NaN
is: CHEBI:27403
is: SBO:0000247
constant: false
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
type: Species
has only substance units: false
is: HMDB12456

metaR LEUtec
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
name: L-leucine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_7d8426d0_2172_41f9_95b4_2074a73d3cc0
is: Q15274
name: QPRT
initial amount: NaN
has only substance units: false
is encoded by: hsa:23475
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

metaR GALASE6ly
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
kinetic law: MODEL1310110006#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110006#
name: beta-galactosidase, lysosomal

metaM Rtotal2coa c
boundary condition: false
name: R total 2 coenzyme A
is: C00086
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16199
constant: false
has only substance units: false
type: Species
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
is: SBO:0000247
is: HMDB00294

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_cc75e307_0455_4b3d_b65b_a3d9df2b28a5
is: Q5MY95
has only substance units: false
initial concentration: NaN
name: ENTPD8
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:377841
constant: false
type: Species

metaM aacoa c
is: C00332
is: HMDB01484
initial concentration: 1.0
has only substance units: false
type: Species
name: Acetoacetyl-CoA
is: SBO:0000247
constant: false
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false
initial amount: NaN

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR S6T5g
reactant: MODEL1310110006#
fast: false
modifier: MODEL1310110006#
type: Reaction
reversible: false
is: SBO:0000176
product: MODEL1310110006#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaM frdp r
is: C00448
is: HMDB00961
boundary condition: false
constant: false
type: Species
name: Farnesyl diphosphate
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763
has only substance units: false
initial amount: NaN

metaR 3HKYNAKGAT
is: SBO:0000176
modifier: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
is described by: ECO:0000304
type: Reaction
fast: false
kinetic law: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.64
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
is version of: http://identifiers.org/ec-code/2.6.1.7

http://identifiers.org/biomodels.db/MODEL1310110006#_1b44a13f_81ca_4813_be51_15cc0f21b968
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1606
name: DGKA
is: P23743

metaM lpam m
initial amount: NaN
name: lipoamide
is: HMDB00962
initial concentration: 1.0
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:17460
has only substance units: false
constant: false

metaR FK
reactant: MODEL1310110006#
product: MODEL1310110006#
name: Fucokinase
is version of: http://identifiers.org/ec-code/2.7.1.52
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110006#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD

metaR PAIL4P HStn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
is described by: ECO:0000000
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
product: MODEL1310110006#
fast: false
is: SBO:0000185
type: Reaction

metaR DCSPTN1COAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
name: fatty acid intracellular transport
fast: false
type: Reaction

metaR D3AIBTm
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
product: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110006#_8a23f897_1061_421f_8599_b995ace3e08c
is: SBO:0000252
boundary condition: true
type: Species
is: Q9NVE7
initial amount: NaN
is encoded by: hsa:55229
name: PANK4
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_d03d3564_08d2_4a31_8464_bbe3c110fa2d
boundary condition: true
name: LDHA
constant: false
is encoded by: hsa:3939
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P00338
type: Species
initial concentration: NaN

metaM pail hs n
has only substance units: false
type: Species
is: CHEBI:57880
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol(1-)
constant: false

metaR r0166
fast: false
product: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
reversible: false
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:

metaR LEULEUPEPT1tc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylleucine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR GPIMTer L
modifier: MODEL1310110006#
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD
is described by: ECO:0000000
type: Reaction
product: MODEL1310110006#
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

metaM xtsn c
is: SBO:0000247
is: CHEBI:18107
name: xanthosine
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
initial concentration: 1.0
type: Species
is: HMDB00299
constant: false

metaM dgtp c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
constant: false
type: Species
is: C00286
has only substance units: false
is: HMDB01440
is: CHEBI:16497
name: dGTP
initial amount: NaN

metaM ttetddcoa m
name: trans5,8tetradecadienoylcoa
initial amount: NaN
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: HMDB02288
is: SBO:0000247

metaR r1691
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
fast: false
reversible: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110006#
product: MODEL1310110006#

metaR CO2tm
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
is: SBO:0000185
name: CO2 transport (diffusion), mitochondrial
product: MODEL1310110006#
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_d7882d0e_93eb_4651_a804_e77e0ebe50a1
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6550
boundary condition: true
name: SLC9A3
initial amount: NaN
has only substance units: false
is: P48764

metaM 3hexdtricoa m
initial amount: NaN
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
name: 3,7,10-hexadecatrienoylcoa
initial concentration: 1.0
is: HMDB02288
constant: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_1c9b1baf_91ac_45ff_b7df_5ab036b2c5bb
is: SBO:0000252
initial amount: NaN
is: Q6I9V5
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:293
boundary condition: true
name: SLC25A6

metaM CE2417 m
type: Species
initial amount: NaN
constant: false
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
is: HMDB11123
boundary condition: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
has only substance units: false
initial concentration: 1.0
is: CHEBI:28387
is: SBO:0000247

metaM txa2 e
has only substance units: false
initial concentration: 1.0
constant: false
name: thromboxane A2(1-)
is: CHEBI:57445
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: HMDB01452

metaM HC01415 m
name: (2E)-Octenoyl-CoA
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
boundary condition: false
is: CHEBI:27537
initial amount: NaN
constant: false

metaR HSAT1ly
fast: false
name: heparan-glucosaminide N-acetyltransferase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110006#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#

metaM cs a deg5 l
is: CHEBI:15936
is: SBO:0000247
boundary condition: false
has only substance units: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5
initial concentration: 1.0
notes: FORMULA: C23H36O24S CHARGE: -2
type: Species
initial amount: NaN
constant: false

metaR NH4t3r
type: Reaction
reactant: MODEL1310110006#
is: SBO:0000185
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
reversible: true
fast: false
name: ammonia transport via proton antiport
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110006#_c307623e_8803_45ce_bb66_994cd0761b68
name: ECI2
type: Species
is: SBO:0000252
is: O75521
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:10455

http://identifiers.org/biomodels.db/MODEL1310110006#_55351566_feb1_41f3_9435_1dd7fda26d4d
has only substance units: false
is encoded by: hsa:1339
boundary condition: true
is: Q02221
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: COX6A2

metaM 4ppcys c
initial concentration: 1.0
is: C04352
type: Species
is: CHEBI:59458
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
constant: false
boundary condition: false
is: HMDB01117
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM dgtp e
boundary condition: false
is: HMDB01440
name: dGTP
initial concentration: 1.0
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:16497
initial amount: NaN

metaM nh4 e
is: HMDB00051
has only substance units: false
type: Species
constant: false
is: CHEBI:28938
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: ammonium
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaR r1961
is: SBO:0000185
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110006#
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
name: Y+LAT2 Utilized transport

metaM tddedicoa m
has only substance units: false
constant: false
initial concentration: 1.0
name: trans3,6dodecadienoylcoa
boundary condition: false
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/5280771

metaM dmnoncrn x
name: 4,8-dimethylnonanoyl carnitine
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C18H37NO4 CHARGE: 0
is: HMDB06202
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN

metaM 5oxpro e
constant: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
is: SBO:0000247
is: CHEBI:57606
is: HMDB00267
initial concentration: 1.0
name: 5-oxoprolinate
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false

metaR C16DCc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_7ed88e4c_ffd5_48c9_a4f8_9aa8f596fdec
name: HAO2
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:51179
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252

metaR NOt
reversible: true
kinetic law: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
name: NO transport (diffusion)
is: SBO:0000185
type: Reaction
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000

metaR DOLPMT L
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.83
name: Dolichyl-phosphate D-mannosyltransferase (liver)
kinetic law: MODEL1310110006#
is: SBO:0000176
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_b64f4d95_c642_4153_b62e_064419774e1f
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:2878
initial concentration: NaN
boundary condition: true
is: P22352
has only substance units: false
initial amount: NaN
name: GPX3

metaR KSII CORE4t
kinetic law: MODEL1310110006#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110006#
product: MODEL1310110006#
name: keratan sulfate II (core4) transport, golgi to extracellular

metaM nh4 c
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
constant: false
is: CHEBI:28938
is: HMDB00051
boundary condition: false
is: C01342
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: Ammonium
type: Species

metaM dgdp c
has only substance units: false
is: HMDB00960
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
is: C00361
initial concentration: 1.0
is: CHEBI:58595
boundary condition: false
name: dGDP

metaM phe L m
initial amount: NaN
is: HMDB00159
is: CHEBI:17295
has only substance units: false
name: L-phenylalanine
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: SBO:0000247
type: Species
boundary condition: false

metaM frdp c
is: HMDB00961
has only substance units: false
is: SBO:0000247
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
boundary condition: false
constant: false
type: Species
is: C00448
is: CHEBI:175763
name: Farnesyl diphosphate
initial amount: NaN
initial concentration: 1.0

metaR r0596
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110006#
reversible: false
is described by: ECO:0000000
fast: false

metaR RE1522M
is described by: ECO:0000000
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
name: RE1522
product: MODEL1310110006#
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176

metaM txa2 r
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
is: CHEBI:57445
type: Species
name: thromboxane A2(1-)
is: HMDB01452
constant: false
has only substance units: false

metaM acrn c
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
name: O-acetylcarnitine
type: Species
is: CHEBI:57589
has only substance units: false
initial amount: NaN
is: HMDB00201
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571

http://identifiers.org/biomodels.db/MODEL1310110006#_b563e003_6b69_44b9_8ea6_31122f3b6a91
has only substance units: false
is: Q9NRA2
is: SBO:0000252
is encoded by: hsa:26503
initial amount: NaN
name: SLC17A5
type: Species
initial concentration: NaN
boundary condition: true
constant: false

metaR C8CRNe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_3c684f5b_9788_48ed_a5ec_95dfb8fe3c5d
name: CPT1A
type: Species
is encoded by: hsa:1374
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is: Q8WZ48
initial concentration: NaN
has only substance units: false

metaR GALASE13ly
type: Reaction
fast: false
name: beta-galactosidase, lysosomal
kinetic law: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110006#
is described by: ECO:0000000
modifier: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110006#

metaM 4hexdtricoa x
boundary condition: false
is: SBO:0000247
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0
name: 4,7,10-hexadecatrienoylcoa
is: HMDB02288
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaR C16DCe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

metaR Asn X Ser Thrtr
reactant: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
type: Reaction
fast: false
reversible: true
name: Asn-X-Ser/Thr transport (from ER to lysosome)
is described by: ECO:0000269
kinetic law: MODEL1310110006#
product: MODEL1310110006#

metaM 5oxpro c
constant: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
is: CHEBI:57606
is: SBO:0000247
initial concentration: 1.0
name: 5-oxoprolinate
has only substance units: false
is: HMDB00267
type: Species
initial amount: NaN
boundary condition: false

metaM aacoa m
boundary condition: false
has only substance units: false
name: acetoacetyl-CoA(4-)
is: CHEBI:57286
initial concentration: 1.0
is: HMDB01484
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332

metaM m5masnC g
is: HMDB02985
is: SBO:0000247
is: CHEBI:58433
initial amount: NaN
constant: false
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C52H87N2O40X CHARGE: 0
boundary condition: false
type: Species

metaR TYRCBOX
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.1.1.28
is: SBO:0000176
kinetic law: MODEL1310110006#
name: L-Tyrosine carboxy-lyase
is described by: ECO:0000134
reversible: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
modifier: MODEL1310110006#
fast: false
type: Reaction
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_16b33136_3756_4c3a_8102_f0d78c7b554a
initial amount: NaN
name: PHPT1
is: Q9P019
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:29085
type: Species
initial concentration: NaN
is: SBO:0000252

metaM acac m
type: Species
initial amount: NaN
constant: false
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0
boundary condition: false
is: HMDB00060
is: SBO:0000247
has only substance units: false
name: acetoacetate

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaM ump n
has only substance units: false
name: UMP(2-)
initial amount: NaN
type: Species
is: CHEBI:57865
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00288
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

metaR C181OHc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecenoylcarnitinec
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_e86ef2b3_1067_445d_8013_55d308317b7c
initial amount: NaN
is: Q9NS00
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:56913
is: SBO:0000252
name: C1GALT1
initial concentration: NaN

metaM docohexcoa x
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
type: Species
name: 2,4,7,10,13,16-docosahexenoylcoa
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false

metaR H6ET3er
reactant: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.8.1
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
fast: false
is described by: ECO:0000000

metaR RE2987X
name: RE2987
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_532ec5af_d7b1_49fe_991d_260295e84318
is: SBO:0000252
is encoded by: hsa:5140
is: A7E2E5
constant: false
initial concentration: NaN
name: PDE3B
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_fce60d76_7256_4983_ace7_74669e0b7121
is: P22033
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:4594
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: MUT

metaR PROSTGE2t
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000269
name: prostaglandin transport via bicarbonate countertransport
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
kinetic law: MODEL1310110006#

metaM cs b deg3 l
has only substance units: false
is: CHEBI:21338
initial concentration: 1.0
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 3
initial amount: NaN
is: SBO:0000247
is: HMDB02704
boundary condition: false
type: Species
constant: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4

metaM sbcoa c
name: suberylcoa
has only substance units: false
is: HMDB00791
is: SBO:0000247
constant: false
is: C02838
initial amount: NaN
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_cb34e93d_0c60_4280_9ff0_03c6f24ab3af
has only substance units: false
name: _LOC727762_1_m
boundary condition: true
type: Species
is encoded by: hsa:LOC727762
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR r0594
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
modifier: MODEL1310110006#
product: MODEL1310110006#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:

metaM 3hmp m
initial concentration: 1.0
is: HMDB00023
constant: false
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
initial amount: NaN
is: SBO:0000247
name: 3-hydroxy-2-methylpropanoate
type: Species
is: CHEBI:11805
boundary condition: false

metaM amet m
has only substance units: false
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: HMDB01185
boundary condition: false
is: C00019
name: S-Adenosyl-L-methionine
is: CHEBI:15414
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false

metaR CRVNCtr
reactant: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
is described by: ECO:0000000
fast: false
name: fatty acid transport via diffusion
reversible: true
product: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaM pail hs c
has only substance units: false
initial concentration: 1.0
is: CHEBI:57880
constant: false
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol(1-)

metaR GALASE20ly
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
fast: false
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110006#_89f8fca2_b3d6_4351_a3bd_6f2940fe9e18
has part: Q86U05
constant: false
boundary condition: true
name: SLC7A8:SLC3A2
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:23428
is: SBO:0000297
type: Species

metaR FAOXC225C226x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_c61e9660_a85d_4910_acdc_5e4290b1465b
is: SBO:0000252
is encoded by: hsa:1841
has only substance units: false
constant: false
initial concentration: NaN
name: DTYMK
is: P23919
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_b7fd99d4_c603_4110_ab15_2d22c2d291ba
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: PYCR1
is encoded by: hsa:5831
initial concentration: NaN
is: A6NFM2
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_dfc6573f_82c6_47b6_ae4c_31f6c3daaa26
initial concentration: NaN
name: PPCDC
type: Species
is: Q96CD2
initial amount: NaN
boundary condition: true
is encoded by: hsa:60490
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_9fcd13f3_58a9_431a_baba_7a9ac1e3bf7b
is encoded by: hsa:1593
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: CYP27A1
type: Species
initial concentration: NaN
boundary condition: true
is: Q02318
constant: false

metaR r0595
name: 3-Mercaptopyruvate:cyanide sulfurtransferase Cysteine metabolism EC:2.8.1.2
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 2.8.1.2 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:851908 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110006#_173085c4_9b5b_494f_8f66_70750f1a5cf9
type: Species
name: OGDH
constant: false
is: SBO:0000252
boundary condition: true
is: Q02218
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:4967

http://identifiers.org/biomodels.db/MODEL1310110006#_7c6d48a5_1e77_46a5_8950_1c81b332e569
initial amount: NaN
has only substance units: false
is encoded by: hsa:6818
name: SULT1A3
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_2bafa604_388a_4c64_b915_669298bb4fae
name: SLC7A9
has only substance units: false
is: P82251
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:11136
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_7522a85b_fc10_4188_9ddb_af173827faf4
initial concentration: NaN
is encoded by: hsa:216
has only substance units: false
name: ALDH1A1
boundary condition: true
type: Species
initial amount: NaN
is: P00352
is: SBO:0000252
constant: false

metaM e4p c
is: CHEBI:16897
constant: false
name: D-Erythrose 4-phosphate
boundary condition: false
is: HMDB01321
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: C00279
type: Species
initial concentration: 1.0

metaR ADNt
fast: false
kinetic law: MODEL1310110006#
name: adenosine facilated transport in cytosol
type: Reaction
is: SBO:0000185
product: MODEL1310110006#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
reactant: MODEL1310110006#
modifier: MODEL1310110006#
reversible: true

metaR EX lac D LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-lactate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_c35fabc2_1263_4aa4_9670_550b811d70d0
name: PGK1
is encoded by: hsa:5230
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: P00558
constant: false
type: Species
has only substance units: false
initial amount: NaN

metaR RE3000M
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110006#
type: Reaction
fast: false
product: MODEL1310110006#
reactant: MODEL1310110006#
name: RE3000
is: SBO:0000176
reversible: true
modifier: MODEL1310110006#

metaR r0013
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
is described by: ECO:0000000
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110006#
reversible: false
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction

metaM ksii core4 pre10 g
is: CHEBI:28067
boundary condition: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 10
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
type: Species

metaR FUMSO3tm
reactant: MODEL1310110006#
is described by: ECO:0000269
product: MODEL1310110006#
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
name: Fumarate:sulfite antiport, mitochondrial
type: Reaction

metaM 4h2oglt m
is: SBO:0000247
constant: false
boundary condition: false
type: Species
has only substance units: false
name: 4-hydroxy-2-oxoglutarate(2-)
is: CHEBI:17742
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
initial concentration: 1.0
is: HMDB02070
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_b7ee1a68_44f2_4d2f_b82d_b582d2b0c101
is encoded by: hsa:57835
is: SBO:0000252
name: SLC4A5
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_a673c9ee_78f2_43a0_8add_eedfaac51975
is: SBO:0000252
type: Species
initial amount: NaN
is: P00441
boundary condition: true
name: SOD1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6647
constant: false

metaR HOCTDACBP
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaM lgnccoa c
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: lignocericyl coenzyme A
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
is: HMDB06526

metaM 3ddecdicoa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial concentration: 1.0
is: C05280
is: HMDB03952
initial amount: NaN
is: SBO:0000247
name: 3,6-dodecadienoylcoa
boundary condition: false
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_1e2a595d_8644_4f9a_b2dc_9d4ab8b62141
name: GCDH
type: Species
constant: false
boundary condition: true
is encoded by: hsa:2639
is: SBO:0000252
is: Q92947
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_891a72a8_8187_49c7_9736_1e4dee1807ae
type: Species
is: SBO:0000252
has only substance units: false
name: CYB5D1
initial amount: NaN
constant: false
is encoded by: hsa:124637
is: Q6P9G0
initial concentration: NaN
boundary condition: true

metaM ump r
constant: false
type: Species
name: UMP
boundary condition: false
is: HMDB00288
is: CHEBI:57865
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247

metaM xol7aone r
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: CHEBI:17899
is: SBO:0000247
is: HMDB01993
initial amount: NaN
type: Species
constant: false
name: 7alpha-hydroxycholest-4-en-3-one
boundary condition: false
has only substance units: false

metaM clpn hs c
initial amount: NaN
is: CHEBI:28494
has only substance units: false
boundary condition: false
type: Species
name: cardiolipin
notes: FORMULA: C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2 CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM chol c
is: C00114
is: HMDB00097
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: Choline
is: CHEBI:15354
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

metaR r0033
product: MODEL1310110006#
kinetic law: MODEL1310110006#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_7f475dcf_3214_40b1_a26c_d3d4d3a59d2a
initial amount: NaN
is: Q6FG42
is encoded by: hsa:4701
name: NDUFA7
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
type: Species

metaR RETH1e
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110006#
name: retinyl ester hydrolase (9-cis), extracellular
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_6406e23c_adea_422f_a773_93f07446513c
is: SBO:0000252
is encoded by: hsa:8309
name: ACOX2
is: Q99424
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species

metaM acac e
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
name: acetoacetate
has only substance units: false
is: CHEBI:13705
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
is: HMDB00060

metaM 7dhchsterol c
constant: false
is: SBO:0000247
type: Species
is: HMDB00032
initial amount: NaN
is: CHEBI:17759
boundary condition: false
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
initial concentration: 1.0
name: cholesta-5,7-dien-3beta-ol

metaR DADA
is described by: ECO:0000269
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.5.4.4
type: Reaction
fast: false
product: MODEL1310110006#
reversible: false
modifier: MODEL1310110006#
reactant: MODEL1310110006#
name: Deoxyadenosine deaminase
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
is: SBO:0000176

metaM ksi deg18 l
type: Species
is: CHEBI:12936
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
name: keratan sulfate I, degradation product 18
boundary condition: false
initial amount: NaN
is: HMDB00143

metaM cs e deg3 l
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:15748
type: Species
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
is: HMDB00127
constant: false
notes: FORMULA: C37H53NO44S4 CHARGE: -6
boundary condition: false
initial concentration: 1.0

metaM dhap c
initial amount: NaN
is: HMDB01473
initial concentration: 1.0
is: C00111
boundary condition: false
constant: false
name: Dihydroxyacetone phosphate
is: SBO:0000247
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/3411
is: CHEBI:57642

http://identifiers.org/biomodels.db/MODEL1310110006#_44035818_0f87_41e2_9497_3b70f6d27b35
initial concentration: NaN
type: Species
is encoded by: hsa:8659
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
name: ALDH4A1

http://identifiers.org/biomodels.db/MODEL1310110006#_68b9866b_de38_4c5a_a9ea_7b1b76962d9b
is encoded by: hsa:204
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: AK2
type: Species
is: SBO:0000252

metaM 4ppcys m
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:59458
initial amount: NaN
is: SBO:0000247
is: HMDB01117
has only substance units: false
constant: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)

metaM chol e
is: HMDB00097
initial concentration: 1.0
boundary condition: false
is: CHEBI:15354
name: Choline
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: C00114
is: SBO:0000247
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

metaR r0591
is described by: ECO:0000000
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
fast: false
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
product: MODEL1310110006#
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_149789c8_0da7_4419_8a95_87429c49ed19
boundary condition: true
is encoded by: hsa:8654
constant: false
is: O76074
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: PDE5A
initial amount: NaN

metaM fgam c
is: HMDB01308
boundary condition: false
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: CHEBI:58426
is: C04376

metaR RE0944E
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.17
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110006#
is: SBO:0000176
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110006#
product: MODEL1310110006#
name: RE0944
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110006#_26f45c20_0ff8_4887_b235_6ca92aab34b4
initial concentration: NaN
name: CRAT
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:1384

metaM tetdec2coa c
name: tetradecadienoylcoa
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: HMDB02014

http://identifiers.org/biomodels.db/MODEL1310110006#_df6b0be8_a585_4c2e_aaf8_a2130e70b4c9
initial amount: NaN
initial concentration: NaN
is: Q9BY49
name: PECR
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:55825
boundary condition: true

metaR HSD11B2r
fast: false
reactant: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reversible: true
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (3291.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
type: Reaction
name: 11-beta-hydroxysteroid dehydrogenase type 2
is version of: http://identifiers.org/ec-code/1.1.1.146

http://identifiers.org/biomodels.db/MODEL1310110006#_019a4f02_57c2_4103_952b_ba584f53c296
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: _AW277253_1_c
is encoded by: hsa:AW277253
is: SBO:0000252

metaR FUCASE2ly
name: alpha-fucosidase, lysosomal
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.51
is described by: ECO:0000000
product: MODEL1310110006#
reversible: false

metaR r0590
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
fast: false
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
product: MODEL1310110006#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
is described by: ECO:0000000

metaM acac c
name: acetoacetate
is: HMDB00060
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0
has only substance units: false

metaM mescoa m
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:27969
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
boundary condition: false
name: Mesaconyl-CoA
constant: false
initial concentration: 1.0
is: C06028

http://identifiers.org/biomodels.db/MODEL1310110006#_99464ad1_87eb_4756_827a_1e9d681a5a2a
name: VNN3
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:55350
initial concentration: NaN
boundary condition: true

metaM T antigen g
notes: FORMULA: C14H24NO10X CHARGE: 0
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:22783
initial amount: NaN
has only substance units: false
name: T antigen (core 1)

metaR RE3218C
type: Reaction
name: RE3218
reversible: true
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.6.2
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
modifier: MODEL1310110006#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_92115f5c_34d5_457b_814c_0ccd6732a7d2
name: CPT1B
initial amount: NaN
constant: false
is encoded by: hsa:1375
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q53FV7

metaR RE2985X
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.17.99.3
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (8310.1) or (8309.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
reactant: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
name: RE2985

metaR ELAIDt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000185
fast: false
name: fatty acid transport via diffusion
type: Reaction
is described by: ECO:0000000

metaM pre prot r
has only substance units: false
name: glycophosphatidylinositol (GPI)-anchored protein precursor
is: HMDB03125
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:16240
initial amount: NaN
is: SBO:0000247
notes: FORMULA: XY CHARGE: 0

metaM acrn x
is: HMDB00201
is: CHEBI:57589
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
name: O-acetylcarnitine
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM dd5ecoa m
is: HMDB13028
initial concentration: 1.0
is: C01942
name: 5-dodecenoylcoa
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
type: Species
constant: false

metaR CO2ter
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
name: CO2 endoplasmic reticular transport via diffusion

metaR r1952
product: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110006#_9cd0495e_8cf0_4cae_9fbc_a4310f7bdda7
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
name: AK4
is: P27144
is encoded by: hsa:205
initial amount: NaN
initial concentration: NaN
constant: false

metaM ins c
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: C00294
is: CHEBI:17596
type: Species
name: Inosine
is: SBO:0000247
is: HMDB00195
initial concentration: 1.0
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294

metaR TYMSULT
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.1
name: Tyramine Sulfotransferase
is described by: ECO:0000269
modifier: MODEL1310110006#
reversible: false
fast: false
is: SBO:0000176
reactant: MODEL1310110006#
product: MODEL1310110006#

metaR G14T11g
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
modifier: MODEL1310110006#
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false

metaM 5aizc c
is: HMDB06273
is: SBO:0000247
is: C04751
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
is: CHEBI:58564

metaR IPDDIx
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110006#
is: SBO:0000176
name: isopentenyl-diphosphate D-isomerase
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
fast: false
reversible: true
product: MODEL1310110006#
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/5.3.3.2
kinetic law: MODEL1310110006#

metaM orn m
constant: false
is: CHEBI:46912
type: Species
notes: FORMULA: C5H13N2O2 CHARGE: 1
name: Ornithine
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C01602
boundary condition: false
is: SBO:0000247
is: HMDB00214

http://identifiers.org/biomodels.db/MODEL1310110006#_0d848146_872e_4318_b161_97b566cbab2e
constant: false
is encoded by: hsa:6647
is: P00441
name: SOD1
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false

metaM mi1345p c
has only substance units: false
boundary condition: false
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
initial amount: NaN
is: HMDB01059
type: Species
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:57895

metaM odecoa m
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
initial amount: NaN
name: Octadecenoyl-CoA (n-C18:1CoA)
constant: false
boundary condition: false
is: HMDB01322
has only substance units: false
initial concentration: 1.0
is: CHEBI:57387
type: Species

metaM n2m2nm l
is: HMDB00573
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C58H97N5O41 CHARGE: 0
name: n2m2nmasn (w/o peptide linkage)
is: CHEBI:30825

metaR CYSTGLUex
modifier: MODEL1310110006#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110006#
reversible: false
reactant: MODEL1310110006#
is: SBO:0000185
name: L-cystine/L-glutamate exchanger
type: Reaction
notes: GENE_ASSOCIATION: (23657.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
product: MODEL1310110006#

metaM aicar e
is: SBO:0000247
is: HMDB01517
is: C04677
notes: FORMULA: C9H13N4O8P CHARGE: -2
boundary condition: false
type: Species
constant: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:58475

http://identifiers.org/biomodels.db/MODEL1310110006#_9cf88169_6901_49cd_9ce6_d313abdb8eed
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AA278423
name: _AA278423_1_c
has only substance units: false

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_36552266_a530_46d5_a62b_f5f41e1bd579
constant: false
has only substance units: false
name: TXNRD1
boundary condition: true
type: Species
is encoded by: hsa:7296
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q16881

metaR FAOXC2442246x
product: MODEL1310110006#
kinetic law: MODEL1310110006#
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000269
type: Reaction

metaM dhcholoylcoa x
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:27393
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: HMDB06895
constant: false

metaM 5forthf c
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
is: SBO:0000247
initial amount: NaN
is: HMDB01534
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: C00664
name: 5-Formiminotetrahydrofolate
is: CHEBI:57456
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_4c0d397c_8a6e_4838_a57e_51111a21a7d1
name: UPP1
constant: false
initial amount: NaN
has only substance units: false
is: Q16831
is encoded by: hsa:7378
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_dfc78700_b2ca_434d_b5f0_eceae4e86309
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: AHCY
boundary condition: true
is encoded by: hsa:191
is: B3KUN3
is: SBO:0000252
has only substance units: false

metaR RIBt
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
name: ribose transport via diffusion
product: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_galacglcgalacglcgal14acglcgalgluside_hs_g
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
has only substance units: false
name: I-antigen
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:26174
type: Species
constant: false

metaR TMDK1
reactant: MODEL1310110006#
name: thymidine kinase (ATP:thymidine)
notes: GENE_ASSOCIATION: (7084.1) or (7083.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.21
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reversible: false
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110006#

metaM HC01104 e
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
name: 4-nitrophenyl phosphate(2-)
is: CHEBI:61146
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
is: SBO:0000247

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_72767d0c_20a9_48ca_aef0_a80a9358fe35
is: O60760
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: HPGDS
type: Species
is encoded by: hsa:27306

http://identifiers.org/biomodels.db/MODEL1310110006#_e39c94c3_0678_4e18_b93a_156b4753b92e
constant: false
name: GUCY2C
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:2984
initial concentration: NaN
is: P25092
initial amount: NaN
has only substance units: false

metaM arachd l
initial amount: NaN
is: CHEBI:32395
name: arachidonate
has only substance units: false
type: Species
is: HMDB01043
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
constant: false
boundary condition: false

metaM g6p c
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: HMDB01401
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: SBO:0000247
is: CHEBI:61548
constant: false
name: D-Glucose 6-phosphate
is: C00092

metaR AHEXASE2ly
kinetic law: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110006#
is: SBO:0000176
modifier: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
type: Reaction
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal

metaM aicar c
is: SBO:0000247
is: HMDB01517
is: C04677
boundary condition: false
has only substance units: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
initial amount: NaN
is: CHEBI:58475

http://identifiers.org/biomodels.db/MODEL1310110006#_ab2e75d8_8dab_4810_8a95_06a7658d8088
initial amount: NaN
is: A0PJK1
is encoded by: hsa:125206
type: Species
initial concentration: NaN
name: SLC5A10
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false

metaM 4ppan c
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
has only substance units: false
name: D-4'-Phosphopantothenate
is: CHEBI:10986
initial concentration: 1.0
is: HMDB01016
is: C03492
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
type: Species

metaR URIt5le
name: uridine transport in via sodium symport (1:2)
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
modifier: MODEL1310110006#
is described by: ECO:0000134
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
reversible: false
is: SBO:0000185
fast: false

metaM forglu c
is: HMDB00854
initial amount: NaN
is: CHEBI:18327
boundary condition: false
type: Species
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
is: C00439
has only substance units: false
name: N-Formimidoyl-L-glutamate
constant: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_7f279aa2_b3cc_4755_82ab_51dac8a7e48c
initial amount: NaN
boundary condition: true
is encoded by: hsa:2879
name: GPX4
is: P36969
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR DGK1
reactant: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.4.8
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is: SBO:0000176
name: deoxyguanylate kinase (dGMP:ATP)
modifier: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
fast: false
type: Reaction

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaM 4hglusa m
name: L-4-hydroxyglutamic semialdehyde
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
is: HMDB06556
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
initial concentration: 1.0
is: CHEBI:27809
boundary condition: false
has only substance units: false

metaR FBP26
is described by: ECO:0000000
modifier: MODEL1310110006#
name: Fructose-2,6-bisphosphate 2-phosphatase
is version of: http://identifiers.org/ec-code/2.7.1.105
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (2203.1) or (5210.1) or (5207.1) or (5209.1) or (5208.1) or (8789.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 3.1.3.46 Confidence Level: 0 AUTHORS: NOTES:IF
kinetic law: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.11
is: SBO:0000176

metaR r1671
modifier: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
name: Y+LAT2 Utilized transport
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110006#
fast: false

metaM core3 g
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: CHEBI:16250
name: Core 3
type: Species
constant: false

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_f25b635a_eb2c_4364_a7bb_69496aaf118d
boundary condition: true
has only substance units: false
constant: false
has part: Q9H3S5
is encoded by: hsa:54965
initial amount: NaN
has part: Q8TBF5
is encoded by: hsa:93183
type: Species
initial concentration: NaN
is: SBO:0000297
name: PIGX:PIGM

http://identifiers.org/biomodels.db/MODEL1310110006#_3c1437a9_a8d1_467f_8fef_a252bf6de459
constant: false
is: Q8N1G6
has only substance units: false
initial amount: NaN
name: GPAM
type: Species
is encoded by: hsa:57678
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR PIACGT
kinetic law: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
name: phosphatidylinositol N-acetylglucosaminyltransferase
is version of: http://identifiers.org/ec-code/2.4.1.198
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.83
fast: false
reversible: false
modifier: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_90f4105b_159c_4a8f_80cc_67395fa000f6
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: MAN1A1
boundary condition: true
is encoded by: hsa:4121
is: P33908
constant: false
has only substance units: false

metaR C162OHe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C16:2OH
type: Reaction

metaM arachd c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
is: CHEBI:32395
initial amount: NaN
boundary condition: false
type: Species
name: arachidonate
constant: false
is: HMDB01043

http://identifiers.org/biomodels.db/MODEL1310110006#_45fd5b45_0977_47cd_b68e_0d50828fc145
name: PDE9A
initial amount: NaN
has only substance units: false
is encoded by: hsa:5152
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
type: Species

metaR NADPHtru
reversible: false
fast: false
name: NADPH transporter, endoplasmic reticulum
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
reactant: MODEL1310110006#
product: MODEL1310110006#

metaR r1527
fast: false
is: SBO:0000185
reactant: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
type: Reaction
modifier: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
is version of: http://identifiers.org/ec-code/4.2.1.1
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_e
is: CHEBI:15347
initial concentration: 1.0
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01659
is: SBO:0000247
name: Type IIIAb
type: Species
boundary condition: false

metaM fum c
constant: false
initial concentration: 1.0
is: CHEBI:29806
name: Fumarate
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: C00122
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00134

metaM pail45p hs c
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:28910
boundary condition: false
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial amount: NaN
initial concentration: 1.0
constant: false

metaM prostge2 c
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
name: prostaglandin E2(1-)
is: HMDB01220
is: CHEBI:606564
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: SBO:0000247

metaM 3ivcrn e
initial concentration: 1.0
notes: FORMULA: C12H23NO5 CHARGE: 0
is: HMDB13336
boundary condition: false
constant: false
has only substance units: false
name: 3-hydroxy-isovaleryl carnitine
initial amount: NaN
is: SBO:0000247
type: Species

metaR DNDPt34m
reversible: false
is described by: ECO:0000269
name: dGDP transport via dTDP antiport
type: Reaction
reactant: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
kinetic law: MODEL1310110006#
is: SBO:0000185

metaR S6T11g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110006#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: false
reactant: MODEL1310110006#
fast: false

metaR SACCD3m
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.8 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
modifier: MODEL1310110006#
type: Reaction
reversible: false
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.8
fast: false
name: saccharopine dehydrogenase (NADP, L-lysine forming), mitochondrial
kinetic law: MODEL1310110006#

metaM dudp c
has only substance units: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
constant: false
is: C01346
is: HMDB01000
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: dUDP
is: CHEBI:60471

metaR FPGS6m
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
name: folylpolyglutamate synthetase (DHF), mitochondrial
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
product: MODEL1310110006#
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.3.2.17
reversible: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaR GGH 5THFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
name: Gamma-glutamyl hydrolase (5THF), extracellular
reversible: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110006#
fast: false
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_11c329fa_2a94_4c7b_a6f3_f564e828fdd7
name: MOGS
is: F5H6D0
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:7841
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_a654fb3e_fdee_4742_8fd4_41f1c70e961c
initial amount: NaN
is: SBO:0000252
name: PIGP
constant: false
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:51227

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_37fbe9cc_67f1_490d_8bfd_9efd7ed67651
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9BZ23
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:80025
name: PANK2

metaM ins e
constant: false
is: CHEBI:17596
is: HMDB00195
initial amount: NaN
name: Inosine
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
has only substance units: false
is: C00294
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_07755cf7_a4da_4a07_b72f_b5b8fbb46d24
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:55350
name: VNN3
type: Species

metaM 3ddecdicoa x
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
boundary condition: false
is: C05280
has only substance units: false
is: SBO:0000247
is: HMDB03952
name: 3,6-dodecadienoylcoa
type: Species
initial concentration: 1.0
constant: false

metaM ddsmsterol r
type: Species
is: SBO:0000247
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
is: CHEBI:27910
has only substance units: false
is: HMDB03896
constant: false
initial concentration: 1.0
initial amount: NaN
name: 7-dehydrodesmosterol
boundary condition: false

metaM 4fumacac c
name: 4-fumarylacetoacetate(2-)
is: HMDB01268
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18034
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_4c6ca93d_ee1d_41c4_9ffd_e4a4d781d5bf
initial amount: NaN
constant: false
is: P04062
type: Species
name: GBA
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2629
has only substance units: false
boundary condition: true

metaM tetpent6coa x
boundary condition: false
initial amount: NaN
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
is: C16172
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: tetracosapentaenoyl coenzyme A, n-6

metaR C162OHc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxy hexadecadienoyl carnitine
type: Reaction

metaR r0145
fast: false
kinetic law: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
modifier: MODEL1310110006#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.3.1
type: Reaction
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
is described by: ECO:0000000
product: MODEL1310110006#
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:61648
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
type: Species
has only substance units: false
initial amount: NaN
name: Type IIIAb
boundary condition: false

metaR TSULt4 3
is described by: ECO:0000269
product: MODEL1310110006#
fast: false
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
kinetic law: MODEL1310110006#
name: thiosulfate transport via sodium symport
modifier: MODEL1310110006#
reactant: MODEL1310110006#

metaR r0718
reactant: MODEL1310110006#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.181
product: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110006#
is: SBO:0000176
fast: false

metaR GCALDD
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.36
name: Glycolaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000176
fast: false
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
reactant: MODEL1310110006#
product: MODEL1310110006#
reversible: false

metaM 3ivcrn c
boundary condition: false
is: http://identifiers.org/pubchem.compound/11966188
has only substance units: false
constant: false
name: 3-hydroxy-isovaleryl carnitine
is: HMDB06870
is: C05998
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C12H23NO5 CHARGE: 0

metaM prostge2 e
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: HMDB01220
name: prostaglandin E2(1-)
is: CHEBI:606564
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584

metaR r1670
is: SBO:0000185
modifier: MODEL1310110006#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
product: MODEL1310110006#
name: Y+LAT2 Utilized transport
reversible: true

metaR DNDPt19m
reactant: MODEL1310110006#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110006#
name: dUDP transport via ATP antiport

metaR r0717
reversible: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176

metaM odecoa c
is: SBO:0000247
initial concentration: 1.0
type: Species
name: Octadecenoyl-CoA (n-C18:1CoA)
is: HMDB01322
is: CHEBI:3793
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

metaM strch2 e
notes: FORMULA: C18H32O16 CHARGE: 0
has only substance units: false
is: CHEBI:4167
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00122
is: SBO:0000247
boundary condition: false
constant: false

metaM glac c
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
is: HMDB06355
type: Species
is: SBO:0000247
name: D-glucurono-6,3-lactone
initial amount: NaN
is: CHEBI:18268

http://identifiers.org/biomodels.db/MODEL1310110006#_3dcd2675_816f_45a1_86cb_a9225408719a
name: GCK
type: Species
has only substance units: false
constant: false
is encoded by: hsa:2645
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM tetde5coa x
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB13109
has only substance units: false
name: 5-tetradecenoylcoa
initial amount: NaN
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_93572d8a_7fc8_4cdc_9ce7_0f3a6e8c8515
name: SLC10A1
type: Species
is encoded by: hsa:6554
constant: false
initial amount: NaN
is: B2RA41
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_938eb8e0_8706_4b80_9b47_d676ec6d97b2
has only substance units: false
is encoded by: hsa:2876
constant: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: P07203
name: GPX1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_d00a3b78_0cb9_45a7_b21a_a6a972d6cc64
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ALAS1
is: SBO:0000252
type: Species
is: Q5JAM2
constant: false
is encoded by: hsa:211

metaM 10fthf7glu e
name: 10-formyltetrahydrofolate-[Glu](7)
initial amount: NaN
type: Species
is: HMDB00972
is: CHEBI:57454
has only substance units: false
is: SBO:0000247
notes: FORMULA: C50H57N13O25 CHARGE: -8
initial concentration: 1.0
boundary condition: false
constant: false

metaM dhap e
has only substance units: false
name: glycerone phosphate(2-)
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57642
constant: false
type: Species
is: HMDB01473

metaR N2M2NMASNt
reactant: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000
name: n2m2nmasn transport, Golgi to extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
fast: false

metaM 7thf e
initial amount: NaN
notes: FORMULA: C49H57N13O24 CHARGE: -8
is: SBO:0000247
has only substance units: false
is: HMDB06559
name: heptaglutamyl folate (THF)
type: Species
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_6e75e4cb_3ad1_494e_96a5_67ce9d122714
initial amount: NaN
name: GALT
has only substance units: false
type: Species
initial concentration: NaN
is: B2RAT6
constant: false
is encoded by: hsa:2592
boundary condition: true
is: SBO:0000252

metaR r0716
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110006#
type: Reaction
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110006#
reversible: false
fast: false
is: SBO:0000176
product: MODEL1310110006#

metaR RE1448N
reversible: true
reactant: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:
type: Reaction
product: MODEL1310110006#
name: RE1448

metaM met L c
has only substance units: false
is: HMDB00696
type: Species
constant: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: CHEBI:16643
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: L-methionine
initial concentration: 1.0

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_02afb8e7_4c68_4ab0_84c2_83a2842e28e7
type: Species
is encoded by: hsa:6817
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: SULT1A1

metaR RE1691M
modifier: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
reversible: true
product: MODEL1310110006#
type: Reaction
fast: false
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.8.1.1
name: RE1691

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaM xol7aone m
has only substance units: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
constant: false
initial amount: NaN
is: HMDB01993
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:17899
name: 7alpha-hydroxycholest-4-en-3-one

metaR r0715
is: SBO:0000176
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
modifier: MODEL1310110006#
product: MODEL1310110006#
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.2.5
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaR SUCOAS1m
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.2.1.4
name: Succinate--CoA ligase (GDP-forming)
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: true
modifier: MODEL1310110006#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_4ddc9468_b765_4ea7_8792_f97fe15cd5f4
type: Species
is: C9JFZ1
initial concentration: NaN
name: SYNJ1
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:8867

http://identifiers.org/biomodels.db/MODEL1310110006#_afdcd73d_495d_43f3_b1e7_00ff6c40a889
constant: false
has only substance units: false
name: SLC2A3
is encoded by: hsa:6515
is: P11169
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_eb3aaa3b_cfc4_44be_b461_ad5c34512f2c
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7166
is: P17752
boundary condition: true
constant: false
initial amount: NaN
name: TPH1
type: Species

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

metaM arachd e
is: SBO:0000247
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
initial amount: NaN
is: CHEBI:32395
initial concentration: 1.0
has only substance units: false
type: Species
name: arachidonate
constant: false
boundary condition: false
is: HMDB01043

metaR 2MB2COAc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

metaR r1673
modifier: MODEL1310110006#
is: SBO:0000185
reactant: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: false
name: Y+LAT2 Utilized transport

metaR r0149
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
product: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.14.13.39
reversible: true

metaR PI4P3K
fast: false
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.1.153
name: phosphatidylinositol 4-phosphate 3-kinase
reversible: false
is: SBO:0000176
modifier: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.1.154
is described by: ECO:0000000
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_8c2bbdf6_5b4e_4aef_84cb_3dbd22040cf3
initial concentration: NaN
type: Species
initial amount: NaN
is: P78356
is: SBO:0000252
is encoded by: hsa:8396
name: PIP4K2B
boundary condition: true
has only substance units: false
constant: false

metaR PNTOte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000134
name: Transport of (R)-Pantothenate
fast: false
reactant: MODEL1310110006#

metaR r0860
reactant: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.1.2.27
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110006#
fast: false
name: Utilized transport

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR r0714
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
reactant: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000176

metaR DECDICRNe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_66f80f66_fe65_490a_9347_6ffb397043f6
constant: false
is: SBO:0000252
has only substance units: false
is: F8W1L5
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:2819
name: GPD1

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_c
is: CHEBI:15347
type: Species
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01659
name: Type IIIAb

http://identifiers.org/biomodels.db/MODEL1310110006#_dcda67cc_4998_43d5_b9cb_b1197851a979
constant: false
name: SRD5A1
is encoded by: hsa:6715
initial amount: NaN
is: P18405
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_cf164ab9_4f50_4db8_9515_611c83c611f4
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q02742
type: Species
is encoded by: hsa:2650
name: GCNT1
initial concentration: NaN
boundary condition: true
constant: false

metaR MMMm
fast: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
product: MODEL1310110006#
type: Reaction
name: methylmalonyl-CoA mutase
is version of: http://identifiers.org/ec-code/5.4.99.2
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_834e4de3_5b11_49d1_961e_2a87610b78c3
is: P37287
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5277
constant: false
name: PIGA
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

metaM ksii core2 deg1 l
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
name: keratan sulfate II (core 2-linked), degradation product 1
is: HMDB00868
has only substance units: false
initial amount: NaN
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
is: CHEBI:57737

metaM met L e
initial concentration: 1.0
name: L-methionine
is: HMDB00696
constant: false
is: SBO:0000247
type: Species
is: CHEBI:16643
has only substance units: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_bcbc2a7f_0604_49cd_a463_9f3cb3ce3310
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
name: RDH14
is encoded by: hsa:57665
constant: false
is: Q9HBH5

http://identifiers.org/biomodels.db/MODEL1310110006#_65bae05d_1b56_4c63_b06b_61886ad61f5d
has only substance units: false
is: Q9NPB1
boundary condition: true
name: NT5M
is: SBO:0000252
is encoded by: hsa:56953
initial concentration: NaN
constant: false
initial amount: NaN
type: Species

metaR APOC LYS BTNPm
product: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
name: proteolysis of apoC-Lys-btn, mitochondrial
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110006#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_f9226285_ab61_4db6_a708_07636489526c
name: SLC27A3
type: Species
boundary condition: true
has only substance units: false
is: Q5K4L6
is encoded by: hsa:11000
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_cc8eae55_b8a3_4779_9397_0995de84a1a8
is: SBO:0000252
name: SLC13A5
is: Q86YT5
initial amount: NaN
type: Species
is encoded by: hsa:284111
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

metaR GALASE12ly
modifier: MODEL1310110006#
name: beta-galactosidase, lysosomal
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
reversible: false
fast: false
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaM hs deg19 l
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
name: heparan sulfate, degradation product 19
initial amount: NaN
is: HMDB01352
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
is: CHEBI:17180
type: Species
is: SBO:0000247

metaM dcholcoa x
initial amount: NaN
name: chenodeoxycholoyl coenzyme a
is: CHEBI:28701
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB06292
type: Species
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_cd1dcd57_0006_4437_95a8_0c2318539daa
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:9107
boundary condition: true
constant: false
type: Species
is: Q9Y217
is: SBO:0000252
name: MTMR6

http://identifiers.org/biomodels.db/MODEL1310110006#_c9af78d4_17a9_44f7_8480_0942a64aad55
initial amount: NaN
boundary condition: true
name: PIGS
is encoded by: hsa:94005
is: Q8NBL9
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_76942ff9_64da_4296_a052_c7f9f281b143
type: Species
has only substance units: false
is encoded by: hsa:5471
boundary condition: true
is: SBO:0000252
constant: false
is: Q06203
initial concentration: NaN
name: PPAT
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_bd14a571_cd1d_437c_8f87_e84922872f36
name: PPCS
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:79717
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q9HAB8

metaR FAOXC6C4x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6-->C4)x
type: Reaction

metaM docosahexcoa m
constant: false
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
name: 3,7,10,13,16,19-docosahexenoylcoa
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_906a2530_ff6b_4a69_b368_79cc6610fdd3
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:4706
has only substance units: false
is: SBO:0000252
name: NDUFAB1
is: O14561
boundary condition: true

metaM ksii core2 pre3 g
notes: FORMULA: C47H76N4O33X CHARGE: -1
has only substance units: false
initial amount: NaN
is: HMDB00175
initial concentration: 1.0
is: SBO:0000247
type: Species
name: keratan sulfate II biosynthesis, precursor 3
is: C00130
is: CHEBI:58053
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_4a850688_6216_425b_b0b4_baf3d5a9f0f9
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: AK4
is: P27144
is encoded by: hsa:205
is: SBO:0000252
boundary condition: true

metaR ASPte
reversible: true
name: diffusion of aspartate into blood
kinetic law: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110006#

metaM 5tedtricoa x
initial concentration: 1.0
is: SBO:0000247
is: HMDB02288
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
name: 5,8,11-tetradecatrienoylcoa
boundary condition: false
initial amount: NaN
constant: false
type: Species

metaR PIt7
product: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000185
name: phosphate transport in/out via three Na+ symporter
reversible: true
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
is described by: ECO:0000269
reactant: MODEL1310110006#
type: Reaction
fast: false

metaM val L m
name: L-valine
is: HMDB00883
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false
constant: false
is: CHEBI:16414

metaM pail45p hs m
is: SBO:0000247
initial amount: NaN
name: phosphatidylinositol 4,5-bisphosphate
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial concentration: 1.0
is: CHEBI:28910
constant: false
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_92150ffb_395e_4cee_b147_d5ad96649180
initial amount: NaN
has only substance units: false
name: SLC1A4
is encoded by: hsa:6509
is: P43007
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

metaR PIK3
fast: false
reversible: false
kinetic law: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.137
name: phosphatidylinositol 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.154
modifier: MODEL1310110006#
is: SBO:0000176

metaR FAOXC5C5DCc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

metaR BDMT L
type: Reaction
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
fast: false
modifier: MODEL1310110006#
reactant: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (liver)
is version of: http://identifiers.org/ec-code/2.4.1.142

metaM ksi deg8 l
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: keratan sulfate I, degradation product 8
is: HMDB00143
is: CHEBI:12936
notes: FORMULA: C194H311N13O171S10 CHARGE: -10
is: SBO:0000247

metaR PIt8
type: Reaction
product: MODEL1310110006#
is described by: ECO:0000006
fast: false
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
reversible: true
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000185
modifier: MODEL1310110006#
name: phosphate transport in/out via Na+ symporter

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_3c14a8a5_82fb_4d28_acad_bf6ae8ff4b18
is encoded by: hsa:1103
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
name: CHAT
constant: false
has only substance units: false
is: Q6LEN6
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_86eca643_591e_44be_b435_eb8731e7c716
initial concentration: NaN
has only substance units: false
is encoded by: hsa:9091
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
name: PIGQ
is: Q9BRB3

http://identifiers.org/biomodels.db/MODEL1310110006#_164dcddc_8638_4866_824e_98ad5d9963d5
initial concentration: NaN
constant: false
is: P08237
name: PFKM
is: SBO:0000252
is encoded by: hsa:5213
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_9e245d95_97b5_4611_9fce_af5322603775
constant: false
is: SBO:0000252
is encoded by: hsa:10606
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P22234
has only substance units: false
name: PAICS

metaR ARGNm
kinetic law: MODEL1310110006#
name: arginase (m)
reversible: false
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.5.3.1
is: SBO:0000176
fast: false
product: MODEL1310110006#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (384.1) SUBSYSTEM: Urea cycle EC Number: 3.5.3.1 Confidence Level: 4 AUTHORS: PMID:9144563 NOTES:SAB m

metaR NaKt
fast: false
is described by: ECO:0000269
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.6.3.9
type: Reaction
is: SBO:0000185
name: Na+/K+ exchanging ATPase
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
reversible: false
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#

metaM strdnc e
type: Species
is: HMDB06547
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: SBO:0000247
is: C16300
name: stearidonic acid C18:4, n-3
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/47205608
initial amount: NaN

metaR CHOLtu
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
is: SBO:0000185
type: Reaction
reactant: MODEL1310110006#
reversible: true
fast: false
product: MODEL1310110006#
name: Choline uniport
is described by: ECO:0000269
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_ffd37371_2965_4ecf_96fe_3aa1d6760cb6
is: Q5FC00
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
type: Species
name: CA6
has only substance units: false
is encoded by: hsa:765
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_7be4441d_527b_413c_8d42_07eaf0a2825d
is: O00754
constant: false
name: MAN2B1
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4125

metaR EX c51crn
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_10189f19_25ad_43f7_bcfd_100f11401cab
boundary condition: true
name: _AA526438_1_c
type: Species
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:AA526438
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_816d0d02_ff64_42a3_a3e6_4190e317c074
type: Species
initial concentration: NaN
name: ENPP2
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5168
is: Q13822

metaM g6p r
constant: false
is: C00092
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
initial concentration: 1.0
type: Species
is: HMDB01401
is: CHEBI:61548
is: SBO:0000247
name: D-Glucose 6-phosphate

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR PHACCOAGLNAC
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
is: SBO:0000176
reactant: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110006#
fast: false

metaR SEBACACT
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaR NADtx
kinetic law: MODEL1310110006#
reversible: true
type: Reaction
name: transport of NAD into peroxisome
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR NDPK10
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reactant: MODEL1310110006#
fast: false
product: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dIDP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
kinetic law: MODEL1310110006#

metaR PRO1xm
reactant: MODEL1310110006#
is described by: ECO:0000254
reversible: false
type: Reaction
fast: false
name: proline oxidase (NAD), mitochondrial
is version of: http://identifiers.org/ec-code/1.5.99.8
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
product: MODEL1310110006#
is: SBO:0000176

metaM oretn n
type: Species
is: CHEBI:58190
initial concentration: 1.0
notes: FORMULA: C20H27O3 CHARGE: -1 INCHI: InChI=1/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/p-1
initial amount: NaN
name: 4-oxo-retinoic acid
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00224
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_f137bec9_fbbc_4cdc_b795_91e4c905eba4
is: Q14442
boundary condition: true
is: SBO:0000252
has only substance units: false
name: PIGH
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:5283
initial amount: NaN

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaR ADRNt
kinetic law: MODEL1310110006#
reversible: true
product: MODEL1310110006#
reactant: MODEL1310110006#
name: fatty acid transport via diffusion
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
fast: false

metaR BDHm
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.1.1.30
fast: false
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
type: Reaction
modifier: MODEL1310110006#
product: MODEL1310110006#
reversible: true
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
is: SBO:0000176
is described by: ECO:0000269

metaR DUTPDPn
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.6.1.23
is: SBO:0000176
type: Reaction
product: MODEL1310110006#
name: dUTP diphosphatase, nuclear
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
reversible: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#

metaR PDHm
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (1738.1 and 8050.1) and (5161.1 and 5162.1) and (1737.1) or (1738.1 and 8050.1) and (5160.1 and 5162.1) and (1737.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12372595,PMID:16436377 NOTES:12372595 - expression; 16436377 - biochemical, tissue-specific
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.12
fast: false
name: pyruvate dehydrogenase
is version of: http://identifiers.org/ec-code/1.8.1.4
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000134
type: Reaction
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.1

metaM xylt c
is: HMDB02917
initial concentration: 1.0
has only substance units: false
is: CHEBI:17151
initial amount: NaN
name: xylitol
is: SBO:0000247
type: Species
constant: false
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379

metaM ksi deg35 l
is: CHEBI:12936
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00143
type: Species
has only substance units: false
name: keratan sulfate I, degradation product 35
initial concentration: 1.0
notes: FORMULA: C68H113N4O54S1 CHARGE: -1

metaM glc D e
type: Species
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
name: D-glucose
has only substance units: false
is: CHEBI:4167
is: HMDB00122
initial concentration: 1.0
initial amount: NaN

metaR FAOXC11C9m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_494d023a_b892_4544_a34a_e5b6c138d184
is encoded by: hsa:52
name: ACP1
type: Species
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: B5MCC7
initial amount: NaN
is: SBO:0000252

metaM ksi pre14 g
name: keratan sulfate I biosynthesis, precursor 14
constant: false
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28067
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species

metaR GLYCtm
is described by: ECO:0000000
name: glycerol transport
product: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
fast: false
reversible: true

metaM hs deg15 l
has only substance units: false
is: SBO:0000247
is: CHEBI:16126
constant: false
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
initial concentration: 1.0
type: Species
boundary condition: false
name: heparan sulfate, degradation product 15
initial amount: NaN

metaM pail45p hs n
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
type: Species
constant: false
is: CHEBI:28910
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate

http://identifiers.org/biomodels.db/MODEL1310110006#_625e16bb_092f_408e_94c6_23b4a7ff93c4
boundary condition: true
name: CMPK1
type: Species
initial concentration: NaN
is encoded by: hsa:51727
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: B2R6S5

http://identifiers.org/biomodels.db/MODEL1310110006#_84995b36_bede_4de6_9676_10c2d5c33ea4
initial amount: NaN
is encoded by: hsa:131669
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: Q68CJ7
initial concentration: NaN
name: UROC1
type: Species

metaM CE2421 m
is: CHEBI:30623
has only substance units: false
name: (3S)-3-hydroxylinoleoyl-CoA
is: HMDB02329
is: SBO:0000247
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_8c3db58b_dab0_4db3_a7b0_d785d598727e
initial amount: NaN
name: _AA854479_1_m
is encoded by: hsa:AA854479
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false

metaM idp c
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: IDP(3-)
is: CHEBI:58280
is: SBO:0000247
type: Species
is: HMDB03335
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_ecae4bf2_1ef5_46a2_ae8d_706583c03d3b
type: Species
constant: false
has only substance units: false
name: PDE9A
is encoded by: hsa:5152
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR ALOX5
name: Arachidonate 5-lipoxygenase
kinetic law: MODEL1310110006#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
fast: false
type: Reaction
modifier: MODEL1310110006#
reversible: false
reactant: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.13.11.34

metaR GALtly
fast: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reversible: false
type: Reaction
is: SBO:0000185
name: galactose efflux from lysosome
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000

metaM alpa hs c
notes: FORMULA: C3H6O5PFULLRCO2 CHARGE: -2 INCHI: InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:52288
constant: false
name: lysophosphatidic acid

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaR RE1233C
is version of: http://identifiers.org/ec-code/2.6.1.64
fast: false
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
modifier: MODEL1310110006#
name: RE1233
reversible: true

metaR PMEVKc
kinetic law: MODEL1310110006#
name: phosphomevalonate kinase, cytosol
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
reversible: false
modifier: MODEL1310110006#
type: Reaction
fast: false
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.4.2
is: SBO:0000176
product: MODEL1310110006#

metaM dcholcoa r
name: chenodeoxycholoyl coenzyme a
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: HMDB06292
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:28701
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_90adbc27_53dd_4cf2_90fc_6277256c5be4
type: Species
boundary condition: true
constant: false
is encoded by: hsa:2348
initial amount: NaN
has only substance units: false
name: FOLR1
initial concentration: NaN
is: SBO:0000252

metaM glc D c
name: D-glucose
is: HMDB00122
initial concentration: 1.0
is: CHEBI:4167
type: Species
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

metaM cholcoads x
constant: false
initial concentration: 1.0
is: CHEBI:27505
is: HMDB06889
initial amount: NaN
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
boundary condition: false
has only substance units: false
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_725a39d1_9dec_45bd_9cce_3b4127da913f
boundary condition: true
is: Q5HYI4
is: SBO:0000252
name: SQLE
is encoded by: hsa:6713
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

metaM CE5132 c
initial concentration: 1.0
is: CHEBI:57923
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false

metaM lneldccoa m
is: HMDB01064
type: Species
name: linoelaidyl coenzyme A
initial concentration: 1.0
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
is: SBO:0000247
boundary condition: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_116fe451_b0c6_4e9b_819e_9bb8356d0577
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: P48728
is: SBO:0000252
name: AMT
type: Species
initial amount: NaN
is encoded by: hsa:275

metaR CHOLtn
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
reversible: true
is: SBO:0000185
fast: false
name: Choline transport, nuclear through pores
product: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_06532b51_115c_4e8b_ba7a_8268a1f782ae
is encoded by: hsa:250
is: P05187
initial amount: NaN
name: ALPP
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
constant: false
boundary condition: true

metaR NP1
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110006#
is described by: ECO:0000304
name: nucleotide phosphatase
type: Reaction
reversible: false
is: SBO:0000176
modifier: MODEL1310110006#

metaM crn e
is: HMDB00062
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: C00318
name: L-Carnitine
is: CHEBI:16347
constant: false
type: Species
has only substance units: false
is: SBO:0000247

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaR r0584
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
is: SBO:0000176
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
reversible: true
is described by: ECO:0000000

metaR ABO9g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.37
type: Reaction
product: MODEL1310110006#
reactant: MODEL1310110006#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
modifier: MODEL1310110006#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ

metaR CHSTEROLtrc
reversible: true
product: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
name: transport of cholesterol into the cytosol
is: SBO:0000185
kinetic law: MODEL1310110006#
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.

metaM idp e
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB03335
name: IDP(3-)
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:58280

metaR PHETHPTOX2
product: MODEL1310110006#
is described by: ECO:0000269
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.14.16.1
fast: false
type: Reaction
reactant: MODEL1310110006#
reversible: false
is: SBO:0000176
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395

metaR S6T4g
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
modifier: MODEL1310110006#
is: SBO:0000176

metaR C102CPT1
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaM 1p3h5c m
constant: false
is: HMDB01369
type: Species
boundary condition: false
initial amount: NaN
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:6151

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaM dgchol x
is: CHEBI:36252
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00637
name: glycochenodeoxycholate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472

metaR INSTt4 2
is described by: ECO:0000006
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
reversible: true
type: Reaction
fast: false
name: inositol transport via sodium symport
reactant: MODEL1310110006#
product: MODEL1310110006#

metaR FUCASE2e
kinetic law: MODEL1310110006#
fast: false
type: Reaction
modifier: MODEL1310110006#
name: alpha-fucosidase, extracellular
is described by: ECO:0000000
reactant: MODEL1310110006#
is: SBO:0000176
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.51
reversible: false

metaM 3hpcoa m
name: 3-hydroxypropanoyl-CoA(4-)
is: HMDB06807
is: CHEBI:58528
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR GULN3D
is: SBO:0000176
fast: false
name: L-gulonate 3-dehydrogenase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110006#
reversible: true
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000

metaM cs b deg2 l
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 2
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H54NO41S3 CHARGE: -5
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:57455
boundary condition: false
is: HMDB01354
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_8b4b23d5_a4e5_4552_bbbb_28ba7c788c7b
initial concentration: NaN
is: Q9UMR5
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:9374
is: SBO:0000252
initial amount: NaN
type: Species
name: PPT2

metaR FORtr
reactant: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110006#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
name: FOR transporter, endoplasmic reticulum

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_05a81d2f_2ed4_46be_a623_8782ef6fd7c6
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: SPHK2
constant: false
is: Q9NRA0
has only substance units: false
initial concentration: NaN
is encoded by: hsa:56848

http://identifiers.org/biomodels.db/MODEL1310110006#_7a0d5e5a_24cd_4577_a507_c870f1f4f928
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: ELOVL5
type: Species
is encoded by: hsa:60481
initial concentration: NaN
is: F6SH78
initial amount: NaN

metaR C142OHc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradeca dienoyl carnitine
type: Reaction

metaM val L e
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
has only substance units: false
boundary condition: false
is: HMDB00883
name: L-valine
is: SBO:0000247
is: CHEBI:16414
initial concentration: 1.0

metaR CYTK14
type: Reaction
kinetic law: MODEL1310110006#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110006#
reversible: true
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP,UTP)
modifier: MODEL1310110006#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_7e6d0041_2ad9_48e8_8c2f_f373e4b41f37
has only substance units: false
is encoded by: hsa:3295
initial concentration: NaN
name: ACAA1:HSD17B4:ACOX1
initial amount: NaN
type: Species
constant: false
has part: E9PB82
is: SBO:0000297
boundary condition: true

metaR BILIRUBt2
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
product: MODEL1310110006#
is described by: ECO:0000269
modifier: MODEL1310110006#
name: bilirubin transport via bicarbonate countertransport
reactant: MODEL1310110006#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110006#
fast: false

metaR r0027
is version of: http://identifiers.org/ec-code/1.14.13.39
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
modifier: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
kinetic law: MODEL1310110006#
fast: false

metaM g1m8mpdol L r
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C1840H3028N20O670P20 CHARGE: -20
has only substance units: false
is: C05870
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog

metaM malttr e
has only substance units: false
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
is: CHEBI:27931
initial amount: NaN
name: maltotriose
boundary condition: false
is: HMDB01262
type: Species
initial concentration: 1.0
is: C01835
is: SBO:0000247
constant: false

metaM dump c
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: CHEBI:246422
type: Species
boundary condition: false
is: HMDB01409
is: C00365
is: SBO:0000247
has only substance units: false
name: dUMP
initial concentration: 1.0
initial amount: NaN
constant: false

metaM 35cgmp c
initial concentration: 1.0
boundary condition: false
name: 3',5'-cyclic GMP(1-)
type: Species
is: CHEBI:57746
is: HMDB01314
constant: false
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM chol m
is: SBO:0000247
name: choline
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:15354
constant: false
is: HMDB00097
initial concentration: 1.0

metaR r0587
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110006#
fast: false
product: MODEL1310110006#
is described by: ECO:0000000
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
modifier: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#

metaR PTPATe
reactant: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
name: PTPATe
product: MODEL1310110006#
reversible: true
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110006#

metaM ficytC m
name: Ferricytochrome c
is: SBO:0000247
boundary condition: false
is: CHEBI:15991
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_ae94fd99_be5a_4e24_8b23_f30b3250133c
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AL525798
constant: false
is: SBO:0000252
initial amount: NaN
name: _AL525798_1_c

metaR FAOXC164x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

metaR SUCCCROT
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of succinyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_9af1eae7_474c_458e_8d53_92c74285c711
type: Species
is encoded by: hsa:2271
name: FH
has only substance units: false
is: P07954
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_13e50cf3_a44d_43a7_88fb_a272f4d67f84
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _AA081045_1_c
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:AA081045
constant: false

metaM val L c
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00883
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
boundary condition: false
initial concentration: 1.0
is: CHEBI:16414
constant: false
name: L-valine

metaR C162ACBP
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

metaM cyan m
is: CHEBI:18407
initial amount: NaN
is: HMDB02084
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
name: hydrogen cyanide

metaR RE2986X
name: RE2986
is described by: ECO:0000000
product: MODEL1310110006#
fast: false
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:10970790,PMID:7775433 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110006#_a9b82964_7f93_46ca_8b85_4bd3362ad8ab
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
type: Species
name: GGT7
is: A0PJJ9
is encoded by: hsa:2686
has only substance units: false

metaM dutp c
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
name: dUTP
is: CHEBI:17625
constant: false
is: C00460
is: HMDB01191
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM fuc12gal14acglcgalgluside hs g
is: CHEBI:57847
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
name: Type IIH glycolipid
constant: false
is: HMDB00304
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0

metaR LTC4CP
is described by: ECO:0000000
product: MODEL1310110006#
fast: false
is: SBO:0000176
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
kinetic law: MODEL1310110006#
type: Reaction
name: Leukotriene C4 carboxypeptidase
reversible: true

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaM CE5119 m
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
is: CHEBI:57923
constant: false
is: SBO:0000247
type: Species
name: trans-3-cis-8-tetradecadienoyl-CoA
has only substance units: false
initial amount: NaN

metaM gbside hs e
is: CHEBI:18259
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: globoside
constant: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
type: Species
is: SBO:0000247
boundary condition: false

metaR r0580
modifier: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.99.7
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:

metaR CYTK12
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
modifier: MODEL1310110006#
reactant: MODEL1310110006#
name: cytidylate kinase (dCMP,dCTP)
reversible: true
kinetic law: MODEL1310110006#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction

metaM chol n
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
name: choline
is: HMDB00097
is: CHEBI:15354
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_292cc3c9_dcbf_448f_9bd1_177a6b85fc5b
name: NNT
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:23530
initial concentration: NaN
type: Species
is: SBO:0000252

metaR r1971
name: Y+LAT2 Utilized transport
product: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#

metaM lneldccoa c
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
name: linoelaidyl coenzyme A
is: HMDB06521
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/9543677
constant: false

metaR AG13T9g
modifier: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000176
fast: false
product: MODEL1310110006#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR N3Tg
fast: false
is: SBO:0000176
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.122
is described by: ECO:0000000
reactant: MODEL1310110006#
product: MODEL1310110006#
reversible: false
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
kinetic law: MODEL1310110006#

metaR FAOXC2051843m
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
fast: false
name: Beta oxidation of fatty acid
product: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110006#

metaM strdnc c
has only substance units: false
constant: false
boundary condition: false
is: HMDB06547
name: stearidonic acid C18:4, n-3
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: http://identifiers.org/pubchem.compound/47205608
initial amount: NaN
is: C16300

http://identifiers.org/biomodels.db/MODEL1310110006#_16b13d9e_ce28_4072_8b4b_02e3c8ce47bd
constant: false
name: GPX2
is: SBO:0000252
is encoded by: hsa:2877
initial amount: NaN
is: P18283
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaM acgam6p c
type: Species
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
is: CHEBI:57513
is: HMDB01062
name: N-acetyl-D-glucosamine 6-phosphate(2-)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR SPC HSt
is described by: ECO:0000000
reactant: MODEL1310110006#
is: SBO:0000185
type: Reaction
product: MODEL1310110006#
name: sphingosylphosphorylcholine transport (diffusion)
fast: false
reversible: true
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:

metaR FAOXC161C161OHm
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of 3-hydroxyhexadecenoylcoA
type: Reaction

metaR ARGt4
name: L-arginine transport in via sodium symport
is described by: ECO:0000304
is: SBO:0000185
fast: false
product: MODEL1310110006#
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
type: Reaction
reversible: false
reactant: MODEL1310110006#

metaR SCP21x
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
fast: false
modifier: MODEL1310110006#
name: Sterol carrier protein 2
reversible: true
product: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#

metaR GCHOLAte
fast: false
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
is described by: ECO:0000000
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110006#
type: Reaction
is: SBO:0000185

metaM nrpphrsf c
constant: false
has only substance units: false
is: HMDB02062
is: SBO:0000247
name: Sulfate derivative of norepinephrine
is: http://identifiers.org/pubchem.compound/123747
type: Species
boundary condition: false
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
initial concentration: 1.0
initial amount: NaN

metaR CYTK13
type: Reaction
reactant: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110006#
kinetic law: MODEL1310110006#
name: cytidylate kinase (dCMP,dATP)
modifier: MODEL1310110006#
reversible: true
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM crn c
has only substance units: false
initial concentration: 1.0
is: CHEBI:16347
is: SBO:0000247
is: HMDB00062
boundary condition: false
initial amount: NaN
constant: false
is: C00318
type: Species
name: L-Carnitine
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

http://identifiers.org/biomodels.db/MODEL1310110006#_850b0008_04c4_41b9_94ea_3ee5c3fab59f
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: Q8N0W3
initial concentration: NaN
is: SBO:0000252
name: FUK
is encoded by: hsa:197258

metaM dhap x
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3411
boundary condition: false
has only substance units: false
name: Dihydroxyacetone phosphate
is: HMDB01473
constant: false
initial amount: NaN
is: C00111
type: Species
is: CHEBI:57642

http://identifiers.org/biomodels.db/MODEL1310110006#_10bbf88b_5f61_4f98_a49f_53775a6c6d82
boundary condition: true
initial amount: NaN
is encoded by: hsa:4967
is: SBO:0000252
constant: false
name: OGDH
type: Species
has only substance units: false
is: Q02218
initial concentration: NaN

metaM 7dhchsterol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
type: Species
is: CHEBI:17759
name: cholesta-5,7-dien-3beta-ol
is: SBO:0000247
initial concentration: 1.0
is: HMDB00032
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false

metaR HISCAT1
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR CYTK10
type: Reaction
fast: false
name: cytidylate kinase (CMP,dGTP)
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
is: SBO:0000176

metaR PYK
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
name: pyruvate kinase
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110006#
fast: false
type: Reaction
product: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:

metaR ACACt2m
reactant: MODEL1310110006#
name: Acetoacetate mitochondrial transport via H+ symport
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
type: Reaction
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
reversible: true
is described by: ECO:0000269
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110006#_6214b33a_2661_4ff1_8876_9eb91a1a2baa
constant: false
is: SBO:0000252
initial concentration: NaN
name: COX7A1
has only substance units: false
is: P24310
is encoded by: hsa:1346
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_da67b7cb_dfb3_4cb4_8fef_6db827fb8e7b
name: TMEM91
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:641649
is: C9JZ62
is: SBO:0000252
initial amount: NaN

metaM gbside hs c
is: SBO:0000247
is: CHEBI:18259
has only substance units: false
initial concentration: 1.0
name: globoside
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
initial amount: NaN
constant: false
type: Species
boundary condition: false

metaR RE1523M
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110006#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
product: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE1523
modifier: MODEL1310110006#

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaR ACOAD1fm
modifier: MODEL1310110006#
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
fast: false
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110006#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110006#_60765abc_97a7_4cd8_abb5_b5fab104b0c4
is: Q9HCQ5
initial concentration: NaN
is encoded by: hsa:50614
type: Species
name: GALNT9
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaM 3aib D m
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
is: HMDB02299
constant: false
is: C03265
is: SBO:0000247
name: D-3-Amino-isobutanoate
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false

metaR RE1532M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
name: RE1532
product: MODEL1310110006#
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaM odecoa r
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:57387
is: HMDB01322
type: Species
name: oleoyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
initial concentration: 1.0

metaR CYTK11
is: SBO:0000176
product: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
name: cytidylate kinase (dCMP,dGTP)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
reversible: true

metaM glac r
name: D-glucurono-6,3-lactone
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
is: HMDB06355
type: Species
is: CHEBI:18268
initial amount: NaN
is: SBO:0000247

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM ksi pre22 g
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 22
constant: false
has only substance units: false
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
is: CHEBI:58053
is: HMDB00175
is: C00130
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR FAOXC5OHc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
type: Reaction

metaR ASCBt4
is described by: ECO:0000269
reversible: true
product: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
name: L-ascorbate transport via proton symport
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
kinetic law: MODEL1310110006#
fast: false
is: SBO:0000185

metaM nrpphrsf e
is: HMDB02062
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
is: http://identifiers.org/pubchem.compound/123747
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
name: Sulfate derivative of norepinephrine

metaM f1p c
has only substance units: false
is: HMDB01076
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
is: CHEBI:18105
is: SBO:0000247
initial amount: NaN
is: C01094
type: Species
initial concentration: 1.0
name: D-Fructose 1-phosphate
boundary condition: false
constant: false

metaR RE3346C
kinetic law: MODEL1310110006#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110006#
name: RE3346
product: MODEL1310110006#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:

metaR XOL27OHtm
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: 27 hydroxy cholesterol transport
reactant: MODEL1310110006#
product: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110006#

metaM ksii core2 pre8 g
is: SBO:0000247
is: CHEBI:58053
has only substance units: false
type: Species
is: C00130
name: keratan sulfate II biosynthesis, precursor 8
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00175
notes: FORMULA: C75H121N6O56SX CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110006#_e082026a_9d14_4ac1_ac5b_ac2f3accb478
is encoded by: hsa:23533
type: Species
is: SBO:0000297
name: PIK3R5:PIK3CG
has part: Q8WYR1
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

metaR ST8SIA11
name: Beta-galactoside alpha-2,3-sialyltransferase
modifier: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
product: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.8
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110006#

metaM b2coa m
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
name: crotonoyl-CoA(4-)
is: HMDB02009
is: CHEBI:57332
constant: false
has only substance units: false

metaR r1841
product: MODEL1310110006#
reversible: false
fast: false
is: SBO:0000185
modifier: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_91a32cd6_d076_44f2_a8ea_39ef1274a472
is encoded by: hsa:BF195998
is: SBO:0000252
has only substance units: false
type: Species
name: _BF195998_1_x
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false

metaM lgnc e
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
name: lignocerate
has only substance units: false
is: CHEBI:31014
boundary condition: false
is: HMDB02003
is: SBO:0000247

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR RE1534M
product: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
modifier: MODEL1310110006#
reactant: MODEL1310110006#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1534
fast: false
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_a51de804_0efe_479d_bd2d_90c73a85c9c5
has only substance units: false
name: PANK1
is: SBO:0000252
is encoded by: hsa:53354
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_c0ce1c5a_ab60_4bfe_baa4_985c645751b6
constant: false
name: SLC12A5
has only substance units: false
initial concentration: NaN
is encoded by: hsa:57468
is: SBO:0000252
is: Q9H2X9
initial amount: NaN
boundary condition: true
type: Species

metaM pheacgln e
type: Species
initial concentration: 1.0
is: CHEBI:58310
has only substance units: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: HMDB06344
is: SBO:0000247
initial amount: NaN
constant: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_9a765e08_ce1c_4274_ae43_310e4482422e
boundary condition: true
initial concentration: NaN
is: Q9H490
is encoded by: hsa:128869
constant: false
name: PIGU
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_a74e4c2e_4d7a_462d_b274_297f18e96877
has only substance units: false
constant: false
is: P06858
name: LPL
is encoded by: hsa:4023
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM zymst r
has only substance units: false
is: CHEBI:18252
type: Species
name: zymosterol
initial amount: NaN
constant: false
is: HMDB06271
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
is: SBO:0000247
initial concentration: 1.0

metaM cs a deg4 l
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01354
constant: false
is: CHEBI:57455
notes: FORMULA: C31H49NO29S CHARGE: -2
type: Species
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
initial amount: NaN

metaM g1m8masn r
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
constant: false
is: C05875
notes: FORMULA: C76H127N2O60X CHARGE: 0
is: SBO:0000247

metaM ura e
constant: false
is: SBO:0000247
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
boundary condition: false
type: Species
initial amount: NaN
is: HMDB00300
is: CHEBI:17568
initial concentration: 1.0
name: uracil
has only substance units: false

metaR FAOXC2452256x
is: SBO:0000176
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110006#
reversible: false
reactant: MODEL1310110006#
name: Beta oxidation of long chain fatty acid
fast: false
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR r1842
is: SBO:0000185
reactant: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
product: MODEL1310110006#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR FAOXC162C162OHm
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:2-->C16:2OH)m
type: Reaction

metaM udpglcur c
is: C00167
has only substance units: false
is: CHEBI:58052
is: HMDB00935
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
name: UDP-D-glucuronate
boundary condition: false
is: SBO:0000247

metaR ACACt2
modifier: MODEL1310110006#
name: acetoacetate transport via proton symport
product: MODEL1310110006#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#

metaR KSII CORE2t
reversible: false
product: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110006#
name: keratan sulfate II (core2) transport, golgi to extracellular
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110006#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_4d7d79be_a302_4c6c_99f0_967f5f4fadc0
initial amount: NaN
name: _D87002_1_m
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:D87002

metaR ACCOAtn
name: acetyl-CoA transport, nuclear
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000185
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaM hx2coa x
name: trans-Hex-2-enoyl-CoA
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: C05998
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB06870
initial amount: NaN
is: http://identifiers.org/pubchem.compound/11966188
constant: false
is: SBO:0000247

metaR r0571
type: Reaction
modifier: MODEL1310110006#
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.8
is described by: ECO:0000000
name: (S)-Methylmalonyl-CoA hydrolase Propanoate metabolism EC:3.1.2.17
reversible: true
product: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.17 Confidence Level: 0 AUTHORS: PMID:3071714,PMID:6885824 NOTES:

metaR OCTDECE1CRNe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-octadecenoyl carnitine into extra cellular space
type: Reaction

metaM dlnlcgcoa r
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
name: dihomo-gamma-linolenyl coenzyme A
is: CHEBI:27979
is: C03595
is: SBO:0000247
boundary condition: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102

metaR SCP22x
name: Sterol carrier protein 2
kinetic law: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
modifier: MODEL1310110006#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.176

http://identifiers.org/biomodels.db/MODEL1310110006#_3ecd52dc_8669_42a1_a4bd_fa444437aee6
constant: false
is encoded by: hsa:126129
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: Q8TCG5
boundary condition: true
name: CPT1C
has only substance units: false

metaR NACHEX2ly
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110006#
fast: false
product: MODEL1310110006#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110006#

metaR NAGAlby
kinetic law: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:Beta-galactosidase B - no evidence to support this actually happens yet; added by analogy with alpha-galactosidase B (NAGAIy) NJ
reversible: false
reactant: MODEL1310110006#
name: N-acetylgalactosaminidase, beta-
is: SBO:0000176
is described by: ECO:0000000

metaR UAGDP
name: UDP-N-acetylglucosamine diphosphorylase
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.7.23
is: SBO:0000176
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110006#
product: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
kinetic law: MODEL1310110006#

metaR r1629
fast: false
product: MODEL1310110006#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110006#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM btamp m
is: CHEBI:3110
boundary condition: false
name: Biotinyl-5'-AMP
initial amount: NaN
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB04220

metaR CRNtx
product: MODEL1310110006#
is: SBO:0000185
name: carnitine transport peroxisome to mitochondria
fast: false
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
type: Reaction
reversible: true
is described by: ECO:0000000

metaM pheacgln c
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: CHEBI:58310
is: HMDB06344
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR OCD11CRNCACT
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_cecaaf32_c434_4ab5_a5d6_24734ac69f15
constant: false
initial amount: NaN
is encoded by: hsa:26289
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: AK5

http://identifiers.org/biomodels.db/MODEL1310110006#_5230d6ee_3ee3_4775_a222_d76cd7b1b914
initial amount: NaN
is: SBO:0000252
is: Q9NNW7
type: Species
constant: false
name: TXNRD2
has only substance units: false
is encoded by: hsa:10587
boundary condition: true
initial concentration: NaN

metaR INSTt2r
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
reversible: true
fast: false
modifier: MODEL1310110006#
name: inositol transport in via proton symport
product: MODEL1310110006#
is described by: ECO:0000269
reactant: MODEL1310110006#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110006#

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaM gdpfuc g
initial amount: NaN
type: Species
name: GDP-L-fucose(2-)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57984
is: HMDB01095
constant: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325

http://identifiers.org/biomodels.db/MODEL1310110006#_a62d93ad_4010_43a1_8b0e_2519b78f65be
constant: false
name: _AI620219_1_m
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI620219
boundary condition: true

metaR r0570
is version of: http://identifiers.org/ec-code/6.3.3.2
reversible: true
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
product: MODEL1310110006#
is described by: ECO:0000000
modifier: MODEL1310110006#
fast: false
is: SBO:0000176
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
kinetic law: MODEL1310110006#
type: Reaction

metaR S6TASE26ly
is: SBO:0000176
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.6.14
type: Reaction
is described by: ECO:0000000
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
kinetic law: MODEL1310110006#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_f53cdc41_be76_4d69_9bbb_4365b9a2cc56
name: DCTD
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
is: P32321
is encoded by: hsa:1635
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_65525156_ac87_4e49_b9fe_05baac2d6d7d
is encoded by: hsa:10201
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: O75414
type: Species
name: NME6

metaR NICRNS
reactant: MODEL1310110006#
is: SBO:0000176
fast: false
type: Reaction
reversible: false
name: NICRNS
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
is described by: ECO:0000000
kinetic law: MODEL1310110006#
product: MODEL1310110006#

metaR FAOXC184C164x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

metaR PSt3
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
reversible: true
product: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000269
name: phosphatidylserine transport
fast: false

metaR FUCtly
reversible: false
name: L-fucose efflux from lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110006#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_79bed102_ad82_4556_a63d_94fd19c7cc12
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: P22392
has only substance units: false
is: SBO:0000252
constant: false
name: NME2
is encoded by: hsa:4831

http://identifiers.org/biomodels.db/MODEL1310110006#_47927637_82de_4044_b9a3_634d5e5df853
is encoded by: hsa:7001
initial concentration: NaN
is: SBO:0000252
name: PRDX2
is: P32119
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species

metaM dcmp c
initial concentration: 1.0
is: C00239
name: dCMP
type: Species
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
constant: false
is: CHEBI:57566
is: HMDB01202
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM hedepecoa m
has only substance units: false
name: 2,4,7,10,13-hexadecapentenoylcoa
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
is: HMDB02288

metaR r0686
modifier: MODEL1310110006#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
product: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110006#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110006#
fast: false

metaR MI14P4P
reversible: false
product: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
is described by: ECO:0000000
name: inositol-1,4-bisphosphate 4-phosphatase
type: Reaction
reactant: MODEL1310110006#
fast: false

metaM thcrm hs g
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:24636
constant: false
name: trihexosyl ceramide
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_3291de5d_9a61_46b7_8f5a_6bfde799fac0
initial amount: NaN
boundary condition: true
name: DPM3
is: SBO:0000252
is: Q86TM7
constant: false
has only substance units: false
is encoded by: hsa:54344
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEtg
is: SBO:0000185
name: blood group intracellular transport
reversible: true
fast: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
type: Reaction

metaR S4TASE2ly
is: SBO:0000176
product: MODEL1310110006#
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.6.12
notes: GENE_ASSOCIATION: (411.2) or (411.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
name: N-acetylgalactosamine-4-sulfatase, lysosomal
kinetic law: MODEL1310110006#
reversible: true
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110006#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_34742eef_15cb_43d6_8928_d0fbf1c46be7
type: Species
is encoded by: hsa:115286
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: SLC25A26
constant: false
boundary condition: true
initial amount: NaN
is: Q70HW3

metaR r1627
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
is: SBO:0000185
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110006#_c72bba5e_ef01_4f2e_9009_f7e12ef8a0f3
constant: false
is encoded by: hsa:65263
is: Q53H96
initial concentration: NaN
name: PYCRL
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_870f0b9a_df71_4928_998d_fd9403e8296a
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: P23219
name: PTGS1
boundary condition: true
is encoded by: hsa:5742
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_db30912f_6b0b_4594_82ee_ff0bc979f641
constant: false
initial amount: NaN
is encoded by: hsa:2222
is: P37268
initial concentration: NaN
has only substance units: false
type: Species
name: FDFT1
boundary condition: true
is: SBO:0000252

metaR GPIAT
reversible: false
name: glucosaminylphosphatidyl inositol acetyltransferase
modifier: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
is: SBO:0000176
reactant: MODEL1310110006#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110006#
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_4546ed0f_ff8f_4b4c_aa02_fd62ca7ab0fa
initial concentration: NaN
is: Q8N142
has only substance units: false
initial amount: NaN
name: ADSSL1
constant: false
is encoded by: hsa:122622
boundary condition: true
type: Species
is: SBO:0000252

metaR LAPCOAe
is: SBO:0000176
reactant: MODEL1310110006#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA catabolism EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
name: LAPCOAe
kinetic law: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_48d3392b_7c5f_472f_aeda_e824e4fe1ea1
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: AKR1C4
initial concentration: NaN
initial amount: NaN
is: P17516
is encoded by: hsa:1109

metaR r2079
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110006#_2edcc298_635c_4624_a1a1_e366f3ebf0ef
constant: false
is encoded by: hsa:10690
initial amount: NaN
initial concentration: NaN
is: Q9Y231
is: SBO:0000252
has only substance units: false
type: Species
name: FUT9
boundary condition: true

metaM ksi pre7 g
notes: FORMULA: C115H187N8O85SX CHARGE: -2
is: CHEBI:58053
is: HMDB00175
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 7
boundary condition: false
initial amount: NaN
is: C00130
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR G14T9g
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaM mescon m
has only substance units: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
name: Mesaconate
initial concentration: 1.0
initial amount: NaN
is: HMDB00749
is: CHEBI:36986
is: SBO:0000247
constant: false
boundary condition: false
type: Species

metaR O2ter
name: O2 transport, endoplasmic reticulum
is described by: ECO:0000000
product: MODEL1310110006#
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110006#
reversible: true

metaR r1628
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM retinal c
is: SBO:0000247
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
is: CHEBI:15035
is: HMDB01358
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: retinal

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

metaR r0002
fast: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
kinetic law: MODEL1310110006#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110006#
name: Active transport

http://identifiers.org/biomodels.db/MODEL1310110006#_50d3b3b4_a8ce_4ca3_a93f_145c829cefef
boundary condition: true
is encoded by: hsa:218
name: ALDH3A1
initial amount: NaN
is: P30838
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR r1625
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110006#
reversible: true
modifier: MODEL1310110006#
type: Reaction

metaM ksi deg31 l
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
constant: false
initial amount: NaN
is: HMDB01354
boundary condition: false
name: keratan sulfate I, degradation product 31
is: CHEBI:57455
has only substance units: false

metaR 2HBt2
fast: false
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110006#
reversible: true
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#
name: 2-hydroxybutyrate cotransport with proton

metaM lanost r
is: SBO:0000247
constant: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
has only substance units: false
name: lanosterol
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:16521
initial concentration: 1.0
is: HMDB01251

metaR r0450
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
reversible: true
reactant: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
fast: false
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.3
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39

metaR r0688
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.2.1.3
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is: SBO:0000176
modifier: MODEL1310110006#
fast: false
type: Reaction
reversible: true
product: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
is described by: ECO:0000000

metaR r0575
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.1.48
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
is: SBO:0000176
reactant: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
type: Reaction
product: MODEL1310110006#

metaM glyc3p c
initial amount: NaN
is: CHEBI:57597
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial concentration: 1.0
is: C00093
is: HMDB00126
has only substance units: false
name: Glycerol 3-phosphate
type: Species
constant: false
is: SBO:0000247
boundary condition: false

metaR FAOXC1811603m
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation fatty acid
is: SBO:0000176
reversible: false
product: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
is described by: ECO:0000269
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110006#
fast: false

metaR r2030
product: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110006#
is described by: ECO:0000000
modifier: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR NACHEX20ly
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
type: Reaction
product: MODEL1310110006#
reversible: false
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_1402e367_abf1_4204_8510_75d76ead59c0
constant: false
is encoded by: hsa:10723
type: Species
has only substance units: false
is: Q9Y666
name: SLC12A7
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR CORE4GTg
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.102
product: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
reversible: false

metaR UDPGLCter
is described by: ECO:0000000
reactant: MODEL1310110006#
type: Reaction
fast: false
kinetic law: MODEL1310110006#
reversible: true
is: SBO:0000185
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD

metaM gdpfuc c
is: SBO:0000247
type: Species
name: GDP-L-fucose(2-)
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01095
is: CHEBI:57984
constant: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
has only substance units: false

metaR ST8SIA12
reversible: false
type: Reaction
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.99.8
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
modifier: MODEL1310110006#
is: SBO:0000176
name: Beta-galactoside alpha-2,3-sialyltransferase
fast: false
product: MODEL1310110006#

metaR PROSTGE1t
fast: false
name: prostaglandin transport via bicarbonate countertransport
kinetic law: MODEL1310110006#
product: MODEL1310110006#
modifier: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110006#_867fac2d_bf1b_4216_91d1_ee5a039aac4b
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:10195
type: Species
name: ALG3
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_cfdad198_f1d0_4af3_b599_1af96ea1b0b6
boundary condition: true
has only substance units: false
name: NDUFA13
is encoded by: hsa:51079
constant: false
is: Q9P0J0
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252

metaM crtsl r
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00063
is: SBO:0000247
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
constant: false
is: CHEBI:17650
name: cortisol
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_e918a8c0_02e2_4ad6_b1aa_fdd36ed1efff
is: SBO:0000252
type: Species
constant: false
name: ACAD10
has only substance units: false
is: G3XAJ0
initial concentration: NaN
boundary condition: true
is encoded by: hsa:80724
initial amount: NaN

metaR RE2626M
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
kinetic law: MODEL1310110006#
is: SBO:0000176
reversible: true
name: RE2626
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110006#
fast: false
is described by: ECO:0000000
product: MODEL1310110006#
modifier: MODEL1310110006#

metaR r1626
product: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000185
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110006#

metaR PROSTGI2tr
kinetic law: MODEL1310110006#
type: Reaction
reversible: true
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110006#
name: Prostaglandin I2 transport (ER)
product: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110006#_b17cd927_cd9f_46da_b4fe_1110d16e24ef
is encoded by: hsa:1375
initial concentration: NaN
type: Species
boundary condition: true
is: B7Z5T8
constant: false
is: SBO:0000252
name: CPT1B
initial amount: NaN
has only substance units: false

metaM dudp n
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
name: dUDP(3-)
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: HMDB01000
is: CHEBI:60471
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_c9c0045b_3583_48fa_bb7a_f893d2c41367
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial concentration: NaN
name: GALNT1
has only substance units: false
is encoded by: hsa:2589
is: Q10472
initial amount: NaN

metaM tetdecdicoa m
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
name: 5,8-tetradecadienoylcoa
is: HMDB02288

metaR r2329
fast: false
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaR UGT1A10r
is: SBO:0000176
product: MODEL1310110006#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.4.1.17
reversible: true
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
reactant: MODEL1310110006#
fast: false
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
modifier: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_8fd771a1_93e9_4ee5_8632_14d60fa3078f
type: Species
initial amount: NaN
is: Q7GXZ4
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4539
name: ND4L

metaR CH25H
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
modifier: MODEL1310110006#
name: cholesterol 25-hydroxylase
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.99.38
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is: SBO:0000176
reversible: false

metaM 2docohexecoa m
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
name: 2,7,10,13,16,19-docosahexenoylcoa
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/24892790

http://identifiers.org/biomodels.db/MODEL1310110006#_47453601_0f63_4df9_add4_298a76350a2d
is encoded by: hsa:5315
initial concentration: NaN
name: PKM2
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_bd693165_dd5e_4f16_9f0d_d3c2ccc5c28e
name: PIGF
is: Q07326
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:5281

metaM gluala e
is: C03740
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
type: Species
is: http://identifiers.org/pubchem.compound/6503
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB06248
has only substance units: false
name: 5-L-Glutamyl-L-alanine

metaR FAOXC180
type: Reaction
product: MODEL1310110006#
is described by: ECO:0000269
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_499f147e_17ae_4178_bcc0_0b9fcf5f810d
is encoded by: hsa:212
type: Species
is: SBO:0000252
constant: false
name: ALAS2
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q5JZF5
has only substance units: false

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaR r2328
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110006#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110006#

metaM so4 e
is: CHEBI:16189
constant: false
name: sulfate
type: Species
is: HMDB01448
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN
boundary condition: false

metaR FAOXC16080m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110006#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110006#
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110006#

metaM hpdcacoa m
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
name: heptadecanoyl coa
has only substance units: false
is: HMDB06497
initial amount: NaN
type: Species

metaR CYTK1n
reactant: MODEL1310110006#
reversible: true
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
name: cytidylate kinase (CMP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110006#
type: Reaction
is: SBO:0000176

metaM thmpp c
is: SBO:0000247
name: Thiamine diphosphate
initial concentration: 1.0
is: CHEBI:45931
initial amount: NaN
type: Species
boundary condition: false
is: C00068
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
has only substance units: false
is: HMDB01372
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_43ddacb2_644c_4722_ad4c_512792ac416d
is: P11310
constant: false
is encoded by: hsa:34
type: Species
boundary condition: true
name: ACADM
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR PROSTGF2t
reversible: true
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
kinetic law: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
name: prostaglandin uniport
modifier: MODEL1310110006#
is described by: ECO:0000269
fast: false

metaR r0579
reactant: MODEL1310110006#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.19
reversible: true
product: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_2f4491a3_078e_4cbd_8252_08f6e0656dac
name: SLC27A4
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:10999
constant: false
initial concentration: NaN
is: Q6P1M0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_1469f374_1ef6_4acd_af1f_87c82306ff6f
is: Q8N4A0
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: GALNT4
is: SBO:0000252
is encoded by: hsa:8693
type: Species

metaR PYAM5POr
kinetic law: MODEL1310110006#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.5
product: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
name: pyridoxamine 5'-phosphate oxidase
is described by: ECO:0000269
reactant: MODEL1310110006#

metaR r2327
kinetic law: MODEL1310110006#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true

metaM zymstnl r
is: HMDB06841
has only substance units: false
boundary condition: false
name: 5alpha-cholest-8-en-3beta-ol
is: CHEBI:16608
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaR LNLNCGt
fast: false
kinetic law: MODEL1310110006#
reversible: true
name: fatty acid transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110006#

metaM dudp m
type: Species
initial amount: NaN
name: dUDP(3-)
is: CHEBI:60471
boundary condition: false
is: HMDB01000
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_f2697965_ae12_4ea8_a6a7_d845f2f9dab6
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P39656
has only substance units: false
is: SBO:0000252
constant: false
name: DDOST
is encoded by: hsa:1650
type: Species

metaR CYSt4
reactant: MODEL1310110006#
modifier: MODEL1310110006#
reversible: false
product: MODEL1310110006#
type: Reaction
is: SBO:0000185
fast: false
name: L-cysteine reversible transport via sodium symport
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110006#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110006#_f01e2fed_9cb1_4850_9e37_c6dbc7a7ed65
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:R06874
has only substance units: false
name: _R06874_1_r

http://identifiers.org/biomodels.db/MODEL1310110006#_c4b89c24_0274_4675_8246_9d6c01d3948c
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: SUCLA2
is: SBO:0000252
is encoded by: hsa:8803
is: E5KS60
constant: false
type: Species

metaR r0340
is version of: http://identifiers.org/ec-code/1.3.1.38
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
modifier: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110006#
fast: false
type: Reaction

metaR r0578
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.1.2.27
fast: false
is: SBO:0000176
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
product: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110006#_9b6a3b8e_9686_4120_a3f3_75f6874582f7
is encoded by: hsa:AV713053
boundary condition: true
name: _AV713053_1_m
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaR r2326
reversible: true
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reactant: MODEL1310110006#
fast: false
product: MODEL1310110006#
type: Reaction
is: SBO:0000185

metaR r0683
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
is described by: ECO:0000000
reversible: false
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
modifier: MODEL1310110006#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110006#
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_ba51d111_8d9c_4596_9088_b6a61b759e03
is encoded by: hsa:1806
is: SBO:0000252
boundary condition: true
is: Q12882
initial concentration: NaN
constant: false
name: DPYD
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_46ec9a14_78ab_424c_bf42_16cf06e7912c
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: O43181
boundary condition: true
name: NDUFS4
type: Species
is encoded by: hsa:4724

metaM ksi pre23 g
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 23
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28067
type: Species
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_9a32a8f8_a1e1_4f22_afae_bfbedc66bfe8
boundary condition: true
type: Species
name: NDUFA6
constant: false
has only substance units: false
is encoded by: hsa:4700
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: P56556

metaM 3m4hpga m
boundary condition: false
has only substance units: false
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
is: C05583
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
initial amount: NaN
is: HMDB04061
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7909

metaR AG13T14g
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
product: MODEL1310110006#

metaR ITCOAL1m
product: MODEL1310110006#
is: SBO:0000176
modifier: MODEL1310110006#
fast: false
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4
type: Reaction
reversible: true
kinetic law: MODEL1310110006#
is described by: ECO:0000304
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110006#_a5c7d77b_45a3_4738_953c_2c00441602f8
boundary condition: true
constant: false
has only substance units: false
name: CDIPT
is encoded by: hsa:10423
initial amount: NaN
type: Species
initial concentration: NaN
is: O14735
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_7a60ed3e_1727_485b_9d13_4c1ae2880837
name: GGT7
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: A0PJJ9
has only substance units: false
is encoded by: hsa:2686
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_fbff448e_5fd5_4b34_b494_2f828ca82726
constant: false
is encoded by: hsa:79087
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ALG12
is: Q9BV10
boundary condition: true

metaM btamp c
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
has only substance units: false
initial amount: NaN
is: HMDB04220
constant: false
is: CHEBI:3110
name: Biotinyl-5'-AMP

http://identifiers.org/biomodels.db/MODEL1310110006#_f9fe8469_b653_4212_8452_3274af374c0a
constant: false
name: PDE9A
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5152

metaR r0456
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.32
reactant: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
reversible: false
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113

metaR FAOXC184C164m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaR r2325
is described by: ECO:0000000
product: MODEL1310110006#
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110006#

metaR CYSTGL
fast: false
notes: GENE_ASSOCIATION: (1491.1) or (1491.2) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.4.1.1 Confidence Level: 4 AUTHORS: PMID:10727430,PMID:15189131 NOTES:NCD
is version of: http://identifiers.org/ec-code/4.4.1.1
reversible: false
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
product: MODEL1310110006#
modifier: MODEL1310110006#
name: cystathionine g-lyase
type: Reaction
is described by: ECO:0000269
is: SBO:0000176

metaR DIDPtn
name: dIDP nuclear transport
is: SBO:0000185
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
is described by: ECO:0000000
product: MODEL1310110006#
fast: false

metaR DOLPMT3 Uer
fast: false
reversible: false
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.260
reactant: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000176
type: Reaction
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)

http://identifiers.org/biomodels.db/MODEL1310110006#_61ca1b8a_3f8e_4e35_9d4f_0506d8479ddc
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10558
initial concentration: NaN
name: SPTLC1
constant: false
boundary condition: true
is: O15269
initial amount: NaN

metaM glyc3p m
is: CHEBI:57597
type: Species
constant: false
has only substance units: false
is: C00093
boundary condition: false
name: Glycerol 3-phosphate
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: HMDB00126

http://identifiers.org/biomodels.db/MODEL1310110006#_df6efa67_fc68_49f1_86a3_bf95df8eb0d8
name: ALPPL2
boundary condition: true
is: P10696
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:251
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_3957d0e1_9586_4fae_81fc_0fc84a6f9610
has only substance units: false
name: SLC34A2
initial amount: NaN
is encoded by: hsa:10568
is: SBO:0000252
initial concentration: NaN
is: O95436
type: Species
constant: false
boundary condition: true

metaR DTMPK
type: Reaction
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.9
name: dTMP kinase
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
modifier: MODEL1310110006#
is described by: ECO:0000269

metaR DNDPt16m
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
fast: false
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
name: dUDP transport via dADP antiport
product: MODEL1310110006#
reactant: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110006#_35801b31_6235_4992_96a6_d5ea545321bd
constant: false
boundary condition: true
is: Q6IB80
initial concentration: NaN
name: NDUFB3
is encoded by: hsa:4709
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_614241cd_dfc0_43dc_841d_62988a14ccba
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4967
constant: false
type: Species
name: OGDH
is: Q02218
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_bc350c60_41f5_4eb9_a5be_2368999b0cba
name: DEGS1
type: Species
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:8560

http://identifiers.org/biomodels.db/MODEL1310110006#_f1364293_e54f_402a_922f_0274d99edb81
constant: false
has only substance units: false
initial concentration: NaN
is: Q13613
name: MTMR1
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8776

metaR r2324
reactant: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110006#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000185

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaM dd2coa m
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: HMDB03712
initial amount: NaN
name: trans-dodec-2-enoyl-CoA(4-)
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: CHEBI:57330

metaR ABTArm
fast: false
is: SBO:0000176
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
reactant: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.19
kinetic law: MODEL1310110006#
reversible: true

metaM gdpddman c
is: SBO:0000247
initial amount: NaN
is: CHEBI:57964
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
type: Species
is: HMDB01346
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
has only substance units: false
constant: false

metaM lgnc c
name: lignocerate
is: HMDB02003
is: CHEBI:31014
boundary condition: false
constant: false
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_751aad40_173b_4440_a4c4_d1d160a5d5cc
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is: Q9NY65
constant: false
is encoded by: hsa:1962
initial amount: NaN
name: EHHADH

metaR RE2626C
name: RE2626
is described by: ECO:0000000
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
product: MODEL1310110006#
fast: false
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110006#

metaR r0680
kinetic law: MODEL1310110006#
reversible: true
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.137
is: SBO:0000176
modifier: MODEL1310110006#
fast: false
type: Reaction
is described by: ECO:0000000

metaR FAOXC225x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

metaR r0345
is described by: ECO:0000000
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
product: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
modifier: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#

metaR CYTK1m
type: Reaction
name: cytidylate kinase (CMP),mitochondrial
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110006#
product: MODEL1310110006#
fast: false
reversible: true
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion

metaR r2323
reactant: MODEL1310110006#
product: MODEL1310110006#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_095e32da_cb1f_42f8_a7d6_3bfae39c0a8e
is encoded by: hsa:124935
is: SBO:0000252
is: Q8N370
has only substance units: false
type: Species
initial amount: NaN
name: SLC43A2
constant: false
boundary condition: true
initial concentration: NaN

metaM dece4coa x
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: 4-decenoylcoa
has only substance units: false
is: SBO:0000247
is: HMDB02145
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_fb4d79c8_b180_4393_8624_c3472801a078
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SLC25A1
constant: false
is: D9HTE9
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6576

http://identifiers.org/biomodels.db/MODEL1310110006#_5cc71295_4e27_48e9_aadf_d89e9fcbe0e0
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:79071
boundary condition: true
name: ELOVL6
is: Q9H5J4
type: Species
has only substance units: false

metaR CITtam
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
product: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000185
type: Reaction
name: citrate transport, mitochondrial
fast: false
is described by: ECO:0000269
modifier: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#

metaM hx2coa m
is: SBO:0000247
type: Species
initial concentration: 1.0
name: trans-Hex-2-enoyl-CoA
is: HMDB06870
is: C05998
boundary condition: false
has only substance units: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/11966188

metaR FAOXC5C3x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_9f015436_aaac_44e4_9649_5c093f3983ad
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: SLCO2A1
type: Species
is encoded by: hsa:6578
is: Q92959
initial concentration: NaN

metaM tdchola x
initial amount: NaN
initial concentration: 1.0
name: taurochenodeoxycholate
type: Species
is: HMDB00951
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: CHEBI:9407

metaR r0009
modifier: MODEL1310110006#
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
type: Reaction
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000000
reactant: MODEL1310110006#

metaM 5eipencoa m
name: 5,8,11,14,17-eicosapentenoylcoa
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_cba52936_e63e_47d6_b323_d2021c9ae755
boundary condition: true
name: SLC35D2
initial concentration: NaN
is: Q76EJ3
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:11046
constant: false

metaR P5CDm
product: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
is described by: ECO:0000269
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.12
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_f786adcc_69d5_4bf0_94b6_4b4a99b67baf
name: PIGQ
is encoded by: hsa:9091
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: B2RAU6
initial concentration: NaN
is: SBO:0000252

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR C10DCc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

metaR B3GNT32g
product: MODEL1310110006#
modifier: MODEL1310110006#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110006#
reversible: false
type: Reaction
reactant: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000269

metaR FAOXC10C8m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)m
type: Reaction

metaM HC01401 m
name: (S)-3-Hydroxydodecanoyl-CoA
has only substance units: false
is: SBO:0000247
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27668
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_5de7ed74_68b5_4c5b_9dde_7e00340afbf8
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:570
is: Q14032
name: BAAT
initial concentration: NaN
is: SBO:0000252
constant: false

metaR r2322
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110006#
fast: false
product: MODEL1310110006#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110006#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_72195968_2ce2_411d_a3c0_6f3e1ce1eb40
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ALDH1A3
initial concentration: NaN
is encoded by: hsa:220
constant: false
has only substance units: false
is: P47895
type: Species

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_58c495c3_8156_4d8d_9595_fec0c46b72c8
constant: false
is: SBO:0000252
has only substance units: false
is: Q96G03
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
name: PGM2
is encoded by: hsa:55276

metaR r0130
type: Reaction
is described by: ECO:0000000
product: MODEL1310110006#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
fast: false
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reactant: MODEL1310110006#

metaM so4 c
name: sulfate
is: CHEBI:16189
constant: false
initial concentration: 1.0
is: HMDB01448
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial amount: NaN

metaR TETDECE1CRNe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_ad0b5409_10ba_4823_9b93_6612145d5f8b
is: SBO:0000252
type: Species
name: PLCB1
initial amount: NaN
has only substance units: false
is encoded by: hsa:23236
is: Q9NQ66
boundary condition: true
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_a21c4cfe_c69e_48a9_800a_1157ef8bb350
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:26063
has only substance units: false
boundary condition: true
is: Q9NUI1
name: DECR2

metaR GGH 10FTHF5GLUe
product: MODEL1310110006#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
modifier: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reactant: MODEL1310110006#
reversible: false

metaR G14T21g
modifier: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
fast: false
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110006#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaR GMPtg
reversible: true
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
name: GMP transport (Golgi)
is described by: ECO:0000269
fast: false

metaM 5adtststerones c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 5alpha-Dihydrotestosterone sulfate
has only substance units: false
is: HMDB06278
boundary condition: false
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
type: Species
constant: false

metaM ala L c
is: HMDB00161
initial concentration: 1.0
name: L-alanine
has only substance units: false
is: CHEBI:16977
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
type: Species

metaM dece3coa x
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
name: 3-decenoylcoa
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/16019966

metaM hs deg6 l
is: HMDB01352
is: CHEBI:17180
boundary condition: false
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
name: heparan sulfate, degradation product 6
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

metaR r2332
is described by: ECO:0000000
product: MODEL1310110006#
reactant: MODEL1310110006#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
reversible: true

metaM crn r
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
name: (R)-carnitine
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
is: CHEBI:16347

metaR UROLACer
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
reactant: MODEL1310110006#
reversible: true
product: MODEL1310110006#
is described by: ECO:0000000
name: uronolactonase, endoplasmic reticulum
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110006#

metaR DESAT16 2
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.14.19.1
reactant: MODEL1310110006#
name: palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)
product: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is described by: ECO:0000000
modifier: MODEL1310110006#

metaM dgmp c
is: SBO:0000247
is: CHEBI:57673
is: HMDB01044
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
boundary condition: false
constant: false
is: C00362
initial amount: NaN
name: dGMP
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_da999fe9_d881_4d61_bbfb_270585915ae9
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P09923
name: ALPI
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:248

metaR 4NPHSFte
is: SBO:0000185
is described by: ECO:0000000
name: xenobiotic transport
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
reversible: true
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_2dab9faa_4bfd_4786_a542_bb2506a17043
is: Q9BTY2
name: FUCA2
initial amount: NaN
constant: false
is encoded by: hsa:2519
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species

metaM so4 m
type: Species
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
name: sulfate
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01448
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:16189

http://identifiers.org/biomodels.db/MODEL1310110006#_b6370feb_d3a5_4ce0_b596_e907f8ea2e95
initial concentration: NaN
constant: false
name: HPRT1
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: P00492
is encoded by: hsa:3251
has only substance units: false

metaM sbcoa x
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
name: suberylcoa
constant: false
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR r0795
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Unassigned EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
reactant: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
is: SBO:0000176
name: Spontaneous reaction
modifier: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.225
type: Reaction
fast: false

metaR r2333
product: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction

metaM tdchola e
is: HMDB00951
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: CHEBI:9407
name: taurochenodeoxycholate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_722276df_4529_4f96_9284_3820ab61c17b
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: CA3
is: P07451
has only substance units: false
is encoded by: hsa:761
boundary condition: true

metaR DM dttp m
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

metaR FAOXC10C8x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaM udp r
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
is: HMDB00295
has only substance units: false
is: CHEBI:58223
is: SBO:0000247
name: UDP
boundary condition: false
initial amount: NaN
constant: false
is: C00015
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_f1ffb2ca_8037_4f1d_bd36_ad00707ddf71
is encoded by: hsa:79751
initial amount: NaN
type: Species
is: Q9H936
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
name: SLC25A22

metaR RE3628M
is described by: ECO:0000000
modifier: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.8
name: RE3628
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110006#

metaR UGLT
is: SBO:0000176
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.7.12
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
name: UDPglucose--hexose-1-phosphate uridylyltransferase
kinetic law: MODEL1310110006#
fast: false
product: MODEL1310110006#

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR FAOXC121C10x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

metaM nadph x
type: Species
name: Nicotinamide adenine dinucleotide phosphate - reduced
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
is: CHEBI:57783
is: C00005
is: HMDB00221

http://identifiers.org/biomodels.db/MODEL1310110006#_f62c9c0d_3fd2_4838_bab9_153bc02a2d57
initial amount: NaN
is: P04075
constant: false
boundary condition: true
name: ALDOA
initial concentration: NaN
is encoded by: hsa:226
type: Species
has only substance units: false
is: SBO:0000252

metaR r0796
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110006#
reactant: MODEL1310110006#
product: MODEL1310110006#
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
kinetic law: MODEL1310110006#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
reversible: true
type: Reaction

metaR r2330
is: SBO:0000185
product: MODEL1310110006#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110006#
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_35b404b5_53bd_46ce_8788_a4ab93b95984
is: B4DFS7
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
name: FUT8
is: SBO:0000252
is encoded by: hsa:2530
initial amount: NaN
type: Species

metaR BPNT
name: 3',5'-bisphosphate nucleotidase
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.7
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: false
fast: false
reactant: MODEL1310110006#
is: SBO:0000176

metaM ala L e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
is: SBO:0000247
is: HMDB00161
initial concentration: 1.0
boundary condition: false
is: CHEBI:16977
type: Species
name: L-alanine
constant: false
initial amount: NaN
has only substance units: false

metaM ksii core4 pre4 g
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: C00130
boundary condition: false
is: CHEBI:58053
constant: false
initial amount: NaN
type: Species
name: keratan sulfate II biosynthesis, precursor 4
is: HMDB00175
is: SBO:0000247

metaM 3mox4hoxm m
boundary condition: false
name: 3-Methoxy-4-hydroxymandelate
is: SBO:0000247
initial amount: NaN
is: HMDB00291
initial concentration: 1.0
constant: false
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
type: Species
has only substance units: false
is: CHEBI:27622

http://identifiers.org/biomodels.db/MODEL1310110006#_39edb481_60ec_4922_9681_70602591f6c4
boundary condition: true
name: ENTPD4
type: Species
is encoded by: hsa:9583
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is: Q9Y227
initial concentration: NaN

metaM tetdecdicoa x
initial amount: NaN
name: 5,8-tetradecadienoylcoa
is: HMDB02288
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_abeecc7d_510d_41f8_8d94_948d9feba6f1
is encoded by: hsa:AA664770
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: _AA664770_1_m

metaM hpdcacoa c
notes: FORMULA: C38H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C38H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-29(47)66-22-21-40-28(46)19-20-41-36(50)33(49)38(2,3)24-59-65(56,57)62-64(54,55)58-23-27-32(61-63(51,52)53)31(48)37(60-27)45-26-44-30-34(39)42-25-43-35(30)45/h25-27,31-33,37,48-49H,4-24H2,1-3H3,(H,40,46)(H,41,50)(H,54,55)(H,56,57)(H2,39,42,43)(H2,51,52,53)/t27-,31-,32-,33+,37-/m1/s1
type: Species
is: HMDB06497
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
name: heptadecanoyl coa
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_f6934abb_e77b_4c22_8653_6b32e5a134e2
is encoded by: hsa:9194
name: SLC16A7
initial amount: NaN
is: Q8NEM3
constant: false
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN

metaM tdchola c
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00951
constant: false
name: taurochenodeoxycholate
is: CHEBI:9407
is: SBO:0000247
type: Species

metaR r0797
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
kinetic law: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
is: SBO:0000176
reversible: true
product: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
name: glycine N-choloyltransferase EC:2.3.1.65
modifier: MODEL1310110006#

metaR FAOXC200180m
name: Beta oxidation of long chain fatty acid
is described by: ECO:0000000
kinetic law: MODEL1310110006#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176

metaM dmpp x
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: prenyl diphosphate(3-)
is: SBO:0000247
is: CHEBI:57623
is: HMDB01120

metaR r2331
type: Reaction
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

metaM ppi x
is: CHEBI:33019
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
has only substance units: false
name: Diphosphate
type: Species
constant: false
is: C00013
is: HMDB00250

metaM Lkynr c
is: HMDB00684
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: CHEBI:16946
initial concentration: 1.0
is: SBO:0000247
name: L-kynurenine
boundary condition: false
type: Species
constant: false

metaM Asn X Ser Thr r
is: CHEBI:28938
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
is: HMDB00051
notes: FORMULA: XH CHARGE: 0
is: C01342
name: protein-linked asparagine residue (N-glycosylation site)
boundary condition: false

metaM glyc3p x
boundary condition: false
initial amount: NaN
is: HMDB00126
initial concentration: 1.0
name: Glycerol 3-phosphate
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
constant: false
type: Species
is: SBO:0000247
is: C00093
is: CHEBI:57597
has only substance units: false

metaR HMGCOARc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110006#
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
is version of: http://identifiers.org/ec-code/1.1.1.34
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
reversible: false

metaR G5SADrm
product: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
type: Reaction
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
reactant: MODEL1310110006#
reversible: true
fast: false

metaM ksi deg38 l
type: Species
constant: false
notes: FORMULA: C54H91N3O41 CHARGE: 0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00143
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I, degradation product 38
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110006#_7f2889dd_74a8_4368_9f7c_f1bce04a450e
is: A5PKZ1
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:11227
initial concentration: NaN
name: GALNT5

metaR ALDD2x
is version of: http://identifiers.org/ec-code/1.2.1.36
reversible: false
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110006#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
name: aldehyde dehydrogenase (acetaldehyde, NAD)

metaM 3hmbcoa m
initial concentration: 1.0
is: HMDB01356
initial amount: NaN
constant: false
is: CHEBI:57312
type: Species
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
boundary condition: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_881296aa_afca_4265_aed9_8e88eac7b07e
type: Species
name: NT5C2
is encoded by: hsa:22978
is: P49902
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_9af43a7f_52ee_4e0d_9dc8_4e13d5517cd4
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
name: SLC5A9
constant: false
boundary condition: true
is encoded by: hsa:200010
is: E9PAK4

metaR G13MT L
modifier: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
type: Reaction
reversible: false
name: Glycolipid 1,3-alpha-D-mannosyltransferase (liver)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.132
reactant: MODEL1310110006#
fast: false

metaR RE3006M
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
name: RE3006
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#

metaR VD3
name: Vitamin D3 formation
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
reversible: true
fast: false
product: MODEL1310110006#
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#

metaR RPE
is: SBO:0000176
kinetic law: MODEL1310110006#
fast: false
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/5.1.3.1
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
modifier: MODEL1310110006#
name: ribulose 5-phosphate 3-epimerase
product: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction

metaR VITD3t2
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110006#
name: Vitamin D3 uptake
is: SBO:0000185
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
reversible: false
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_b3852826_fecb_4ba1_a71d_ca28512085c9
boundary condition: true
initial concentration: NaN
is: Q99999
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:9514
type: Species
name: GAL3ST1

metaR S6TASE21ly
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
modifier: MODEL1310110006#
name: N-acetylglucosamine-6-sulfatase, lysosomal
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14

metaM Asn X Ser Thr l
type: Species
notes: FORMULA: XH CHARGE: 0
is: CHEBI:28938
boundary condition: false
name: protein-linked asparagine residue (N-glycosylation site)
is: HMDB00051
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C01342
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_1cfb1686_2623_4a55_be85_52921cf7e3a9
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: DGKD
initial amount: NaN
constant: false
is encoded by: hsa:8527

metaR ALDD2y
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110006#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.2.1.36
fast: false
name: aldehyde dehydrogenase (acetaldehyde, NADP)
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177

http://identifiers.org/biomodels.db/MODEL1310110006#_95b58beb_d960_4177_896e_7166ea0ce28b
type: Species
constant: false
has only substance units: false
name: PDE1B
is: Q7Z364
boundary condition: true
is encoded by: hsa:5153
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM dlnlcgcoa c
has only substance units: false
initial amount: NaN
name: dihomo-gamma-linolenyl coenzyme A
is: CHEBI:27979
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102

metaM trp L c
boundary condition: false
type: Species
is: CHEBI:16828
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
name: L-tryptophan
is: HMDB00929
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_3ab8f644_69a1_41fe_a248_3012e6df102a
type: Species
constant: false
name: DHFR
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P00374
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1719

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaM 3htdcoa m
name: (S)-3-Hydroxytetradecanoyl-CoA
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB02288
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
type: Species
boundary condition: false

metaR NRPPHRtu
product: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
name: Norepinephrine uniport
is described by: ECO:0000269

metaR FAOXC163Gm
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaR DNDPt38m
product: MODEL1310110006#
kinetic law: MODEL1310110006#
name: dUTP transport via dUDP antiport
reactant: MODEL1310110006#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
reversible: false
modifier: MODEL1310110006#
type: Reaction
is: SBO:0000185

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_097ed573_8de1_4909_8381_dac003f2a744
constant: false
type: Species
is: Q9NXB9
name: ELOVL2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:54898
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM crn x
name: L-Carnitine
is: HMDB00062
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:16347
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
is: C00318
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_fa456a9e_7a4e_40da_980e_2b97fcad1b0b
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:50487
initial amount: NaN
is: Q9NZ20
is: SBO:0000252
boundary condition: true
name: PLA2G3

metaR FAOXC150m
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
name: Beta oxidation of long chain fatty acid (odd chain)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
modifier: MODEL1310110006#

metaR ARACHDCOAtx
name: fatty acid intracellular transport
is: SBO:0000185
reactant: MODEL1310110006#
product: MODEL1310110006#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction

metaR GluForTx
kinetic law: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110006#
name: Glutamate formimidoyltransferase
reversible: false
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.1.2.5
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_76242a2c_0822_47e4_92a3_198c77da9f64
is: B4DK61
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51
has only substance units: false
type: Species
name: ACOX1

http://identifiers.org/biomodels.db/MODEL1310110006#_b793267d_ea8d_448b_b90c_951bb8c7cdf8
initial concentration: NaN
is encoded by: hsa:5631
name: PRPS1
type: Species
has only substance units: false
constant: false
is: P60891
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM 3ivcoa c
is: HMDB06870
is: C05998
initial amount: NaN
constant: false
is: SBO:0000247
name: 3-hydroxyisovalerylcoa
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/11966188
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4

metaM saccrp L m
notes: FORMULA: C11H19N2O6 CHARGE: -1 INCHI: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/p-1/t7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00363
is: HMDB00279
initial amount: NaN
has only substance units: false
constant: false
name: L-saccharopinate(1-)
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:57951
initial concentration: 1.0

metaR GULLACter
reactant: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
kinetic law: MODEL1310110006#
reversible: false
type: Reaction
name: gulonolactone endoplasmic reticular transport
is described by: ECO:0000000
product: MODEL1310110006#
fast: false

metaM dgmp e
constant: false
is: SBO:0000247
is: HMDB01044
initial amount: NaN
boundary condition: false
name: dGMP(2-)
type: Species
is: CHEBI:57673
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
has only substance units: false
initial concentration: 1.0

metaR ACACT7p
is described by: ECO:0000269
modifier: MODEL1310110006#
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
reversible: false
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is: SBO:0000176
type: Reaction
fast: false

metaR r0127
kinetic law: MODEL1310110006#
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
product: MODEL1310110006#
is: SBO:0000176
reversible: false
reactant: MODEL1310110006#
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:

metaR RPI
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.3.1.6
fast: false
reactant: MODEL1310110006#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
type: Reaction
modifier: MODEL1310110006#
name: ribose-5-phosphate isomerase

metaR r1512
product: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
fast: false
type: Reaction
is: SBO:0000185
name: Utilized transport
reactant: MODEL1310110006#
is described by: ECO:0000000

metaR MDHm
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
fast: false
reactant: MODEL1310110006#
is described by: ECO:0000134
name: malate dehydrogenase, mitochondrial
is: SBO:0000176
product: MODEL1310110006#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.37
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction

metaM 3hpp m
constant: false
name: 3-hydroxypropionate
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
is: SBO:0000247
type: Species
is: CHEBI:16510
is: HMDB00700

metaM so4 l
has only substance units: false
type: Species
name: sulfate
is: CHEBI:16189
is: SBO:0000247
is: HMDB01448
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false

metaR SGPL12r
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
fast: false
reactant: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000304
reversible: false
name: Sphingosine-1-phosphate lyase
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.27
product: MODEL1310110006#

metaM c226crn c
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: cervonyl carnitine
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/127055
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
is: HMDB06510
initial concentration: 1.0

metaR ASPTAm
kinetic law: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110006#
fast: false
type: Reaction
modifier: MODEL1310110006#
name: aspartate transaminase

metaM trp L e
constant: false
name: L-tryptophan
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial concentration: 1.0
type: Species
is: CHEBI:16828
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00929
initial amount: NaN

metaR FAOXC10C10OHm
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

metaR FAOXC225m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaR DESAT20 1
product: MODEL1310110006#
is: SBO:0000176
reactant: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110006#
fast: false
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)

metaR S23T3g
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
kinetic law: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000176
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
is version of: http://identifiers.org/ec-code/2.4.99.6
product: MODEL1310110006#
fast: false
type: Reaction
modifier: MODEL1310110006#
reactant: MODEL1310110006#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110006#_ab0ea8d5_5172_4c6e_8e65_f6613e9697e6
boundary condition: true
name: NMNAT3
has only substance units: false
type: Species
constant: false
is encoded by: hsa:349565
initial concentration: NaN
is: Q96T66
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_25062925_d662_4638_94e9_09862022d62c
initial amount: NaN
is encoded by: hsa:956
type: Species
boundary condition: true
constant: false
name: ENTPD3
is: O75355
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR r1624
reversible: true
product: MODEL1310110006#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110006#
type: Reaction

metaM dd2coa c
name: trans-Dodec-2-enoyl-CoA
initial amount: NaN
is: SBO:0000247
is: HMDB03712
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
type: Species

metaM c226crn m
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
has only substance units: false
is: SBO:0000247
is: HMDB06510
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: cervonyl carnitine
is: http://identifiers.org/pubchem.compound/127055
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_03f23ed8_89a8_4811_ade7_1181b0d8f5d8
type: Species
initial amount: NaN
is: Q9UBK5
initial concentration: NaN
is encoded by: hsa:10870
boundary condition: true
name: HCST
constant: false
is: SBO:0000252
has only substance units: false

metaM ppi r
is: CHEBI:33019
initial concentration: 1.0
is: HMDB00250
type: Species
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
boundary condition: false
initial amount: NaN
name: Diphosphate

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

metaM betald c
has only substance units: false
constant: false
is: HMDB01252
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:15710
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: SBO:0000247
name: betaine aldehyde

http://identifiers.org/biomodels.db/MODEL1310110006#_b4ca1002_7d62_4105_9aaf_a5d037ac65eb
name: NDUFV3
is encoded by: hsa:4731
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species

metaR r1623
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110006#
fast: false
reversible: true
type: Reaction
product: MODEL1310110006#
is: SBO:0000185

metaM ctp c
is: C00063
initial amount: NaN
is: HMDB00082
name: CTP
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: SBO:0000247
boundary condition: false
is: CHEBI:37563

metaR r0129
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000176
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
kinetic law: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110006#_e465d7b4_6ed2_4871_8a39_42ac2ac73bfe
boundary condition: true
is: SBO:0000252
name: MTHFD2L
initial amount: NaN
is: Q9H903
has only substance units: false
is encoded by: hsa:441024
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_3fe7cd35_f6d7_425a_ae0d_8d303809c86c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P21108
boundary condition: true
type: Species
name: PRPS1L1
is encoded by: hsa:221823
constant: false

metaR r1848
name: Y+LAT2 Utilized transport
reactant: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_ce97fbc9_69a9_4a3d_b7d6_0613b1989652
boundary condition: true
is: SBO:0000252
name: MYO5B
type: Species
is: Q9H6Y6
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4645

metaR ORETNF
name: 4-oxo-retinoic acid formation (oxidation)
type: Reaction
kinetic law: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
product: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_138e558d_bec3_4841_9501_ebb48c535788
initial amount: NaN
is: Q9NSC7
is encoded by: hsa:55808
boundary condition: true
is: SBO:0000252
constant: false
name: ST6GALNAC1
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_7ea41ade_4536_423b_959b_69efad428940
initial concentration: NaN
is: P15848
has only substance units: false
boundary condition: true
is encoded by: hsa:411
name: ARSB
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

metaM mn l
constant: false
is: SBO:0000247
is: HMDB06535
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
boundary condition: false
initial amount: NaN
has only substance units: false
name: beta-1,4-mannose-N-acetylglucosamine
type: Species
initial concentration: 1.0

metaM ksi pre28 g
is: CHEBI:58053
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 28
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
is: C00130
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00175

http://identifiers.org/biomodels.db/MODEL1310110006#_18b5e4cc_a62c_4839_b7d3_3d382031efc5
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1718
initial concentration: NaN
is: Q15392
boundary condition: true
name: DHCR24
has only substance units: false
type: Species

metaM ksi pre31 g
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
type: Species
is: C00130
is: HMDB00175
is: CHEBI:58053
boundary condition: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 31
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false

metaR PRISTCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
name: pristcoa peroxisomal transport
reactant: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
product: MODEL1310110006#

metaR r1622
type: Reaction
product: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110006#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110006#
reversible: true

metaR NACHEX16ly
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
fast: false
product: MODEL1310110006#
is: SBO:0000176
reversible: false
modifier: MODEL1310110006#
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD

metaR NACHEXA21ly
is: SBO:0000176
fast: false
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
type: Reaction
is described by: ECO:0000000

metaM 3m4hpga c
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7909
is: HMDB04061
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
is: C05583
constant: false
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
initial amount: NaN

metaR RE0691C
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110006#
name: RE0691
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_862cc8f0_c241_477a_8ccc_f2a4813256d2
is encoded by: hsa:1666
boundary condition: true
has only substance units: false
is: Q16698
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: DECR1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_92bc1008_2fe1_464d_8f77_ec7495250793
is: P51178
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: PLCD1
type: Species
is: SBO:0000252
is encoded by: hsa:5333

http://identifiers.org/biomodels.db/MODEL1310110006#_3c69e4eb_7087_4482_b1bc_eeca71da23de
is encoded by: hsa:4705
boundary condition: true
type: Species
is: O95299
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: NDUFA10

metaM nadph r
boundary condition: false
is: C00005
is: HMDB00221
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
has only substance units: false
initial concentration: 1.0
is: CHEBI:57783
is: SBO:0000247
type: Species
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_7697f579_d7f4_49b9_afe2_7a9a16a9703e
initial amount: NaN
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5152
is: SBO:0000252
name: PDE9A

metaM n2m2nmasn l
notes: FORMULA: C58H96N5O40X CHARGE: 0
is: SBO:0000247
is: C04946
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R

metaR r0236
is version of: http://identifiers.org/ec-code/3.5.1.6
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
kinetic law: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110006#
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
reactant: MODEL1310110006#

metaR r1621
reversible: true
fast: false
reactant: MODEL1310110006#
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110006#
type: Reaction
is: SBO:0000185

metaR SQLEr
is version of: http://identifiers.org/ec-code/1.14.13.132
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
name: Squalene epoxidase, endoplasmic reticular (NADP)
is: SBO:0000176
modifier: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
is described by: ECO:0000134

metaM ctp e
is: SBO:0000247
initial amount: NaN
name: CTP(4-)
is: HMDB00082
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
type: Species

metaM didp c
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:28823
initial amount: NaN
is: HMDB03536
constant: false
name: dIDP
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344

metaM retinol 9 cis e
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:17336
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
name: 9-cis-retinol
is: HMDB06217

metaM n2m2nmasn e
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
notes: FORMULA: C58H96N5O40X CHARGE: 0
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: C04946
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_fucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
constant: false
is: SBO:0000247
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
initial concentration: 1.0
has only substance units: false
is: CHEBI:16094
boundary condition: false
type: Species
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
initial amount: NaN
is: HMDB00257

http://identifiers.org/biomodels.db/MODEL1310110006#_d7670d7d_edf4_4629_81c8_66238c58edf3
name: LGSN
boundary condition: true
initial amount: NaN
is: Q5TDP6
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:51557

metaM crn m
constant: false
type: Species
is: CHEBI:16347
is: HMDB00062
boundary condition: false
is: C00318
initial concentration: 1.0
name: L-Carnitine
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_1838a752_9ace_493e_8650_10c7a50ee160
type: Species
boundary condition: true
is: P30038
is encoded by: hsa:8659
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: ALDH4A1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_a8761a5c_42ab_4d97_a4d3_b11b92a706ec
initial concentration: NaN
constant: false
is encoded by: hsa:109
is: B3KT86
initial amount: NaN
name: ADCY3
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true

metaM 3ivcoa m
has only substance units: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
is: HMDB06870
is: http://identifiers.org/pubchem.compound/11966188
constant: false
name: 3-hydroxyisovalerylcoa
is: C05998
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_54b9d168_a242_4546_a9c0_97fb8375c467
has only substance units: false
name: ACO1
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: P21399
is encoded by: hsa:48

metaR CERT2gt
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
modifier: MODEL1310110006#
product: MODEL1310110006#
name: ceramide transport protein
fast: false
reversible: true
kinetic law: MODEL1310110006#

metaR r1620
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110006#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
fast: false
type: Reaction

metaM ksi pre12 g
initial amount: NaN
is: CHEBI:58053
is: HMDB00175
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: C00130
type: Species
constant: false
name: keratan sulfate I biosynthesis, precursor 12
notes: FORMULA: C135H218N9O106S3X CHARGE: -4

metaR ASPGLUm
is: SBO:0000185
name: aspartate-glutamate mitochondrial shuttle
reactant: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_9cd71bd8_b585_43d9_b5a9_d7d4a2a7f13b
initial amount: NaN
constant: false
initial concentration: NaN
is: P13866
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6523
name: SLC5A1
boundary condition: true

metaR DM fol
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaR GLYOX
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.6
kinetic law: MODEL1310110006#
name: hydroxyacylglutathione hydrolase
reversible: false
type: Reaction
product: MODEL1310110006#
is described by: ECO:0000269
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF
reactant: MODEL1310110006#
is: SBO:0000176

metaR PHCDm
is version of: http://identifiers.org/ec-code/1.5.1.12
product: MODEL1310110006#
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
reactant: MODEL1310110006#
is: SBO:0000176
reversible: false
fast: false
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_f870728f_3445_4942_af90_90bed0aa9b01
is encoded by: hsa:4831
type: Species
has only substance units: false
name: NME2
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P22392

metaR RE2996X
is version of: http://identifiers.org/ec-code/1.3.1.34
product: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
fast: false
reversible: true
name: RE2996
is described by: ECO:0000000
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (26063.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110006#
is: SBO:0000176

metaM dece3coa m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false
type: Species
name: 3-decenoylcoa
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR r0791
type: Reaction
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110006#

metaR FAOXC260240x
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110006#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c26:0 -> c24:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 -> into pmtcoa NJ
fast: false

metaR P45027A1m
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Cytochrome P450 27
modifier: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000176
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_fucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:61648
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
is: SBO:0000247
has only substance units: false
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0

metaR STRDNCt
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110006#
name: fatty acid transport via diffusion
reactant: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
product: MODEL1310110006#

metaR FAOXC16DCr
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaM n2m2nmasn g
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
constant: false
type: Species
is: C04946

metaR FAOXC9C7m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

metaM dsT antigen g
notes: FORMULA: C36H56N3O26X CHARGE: -2
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB01440
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:16497
name: disialyl-T antigen

metaM ksii core2 deg6 l
is: HMDB00143
has only substance units: false
initial concentration: 1.0
type: Species
name: keratan sulfate II (core 2-linked), degradation product 6
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:12936
boundary condition: false
notes: FORMULA: C44H72N4O33SX CHARGE: -1

metaM gdpmann c
boundary condition: false
is: SBO:0000247
is: HMDB01163
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:57527
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
name: GDP-alpha-D-mannose(2-)
type: Species
initial concentration: 1.0

metaR APOC LYS BTNP
is: SBO:0000176
type: Reaction
product: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
reversible: false
is described by: ECO:0000000
name: proteolysis of apoC-Lys-btn
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110006#

metaM andrstandn r
name: 5alpha-androstane-3,17-dione
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00899
type: Species
boundary condition: false
constant: false
is: CHEBI:15994
has only substance units: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674

http://identifiers.org/biomodels.db/MODEL1310110006#_5b8e10be_5352_4168_8c60_8383b56d7019
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:57282
initial concentration: NaN
is: B7Z1R0
type: Species
name: SLC4A10
initial amount: NaN
is: SBO:0000252

metaR r0792
product: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 0 AUTHORS: PMID:1119805,PMID:2383427 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
fast: false
name: 5-methyltetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate / Methane metabolism EC:1.5.1.20
reversible: true

metaM ura c
type: Species
initial concentration: 1.0
name: Uracil
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00300
is: C00106
is: CHEBI:17568
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_b46b8e4e_43ea_480f_88b8_888a73870d73
initial amount: NaN
boundary condition: true
name: MTR
is: Q99707
is encoded by: hsa:4548
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_b01e358e_66d3_42c8_bdf4_873a416cccc3
is: O95299
boundary condition: true
has only substance units: false
name: NDUFA10
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4705

http://identifiers.org/biomodels.db/MODEL1310110006#_8419d5ce_72b0_4b1f_9df3_3e659f743c9c
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: _R39999_1_c
initial concentration: NaN
is encoded by: hsa:R39999

metaM 3htdcoa c
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
name: (S)-3-Hydroxytetradecanoyl-CoA
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB02014
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaR DESAT20 2
product: MODEL1310110006#
is: SBO:0000176
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
fast: false
is described by: ECO:0000000
modifier: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
type: Reaction

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaR Ser Thrtg
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
name: Ser/Thr transport (from golgi to lysosome)
product: MODEL1310110006#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110006#_2e076215_11c2_4503_afbd_ec5421b0b9da
type: Species
is encoded by: hsa:92745
initial concentration: NaN
boundary condition: true
is: Q8WUX1
constant: false
name: SLC38A5
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM dolp U c
name: dolichyl phosphate(2-)
type: Species
is: CHEBI:57683
boundary condition: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0

metaR AG13T4g
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
modifier: MODEL1310110006#
fast: false
reversible: false
type: Reaction
product: MODEL1310110006#

metaM retinol 9 cis c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
initial amount: NaN
is: HMDB06217
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:17336
name: 9-cis-retinol
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR C121CPT1
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_20413828_4620_4e8b_95ad_830a7e35b99c
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P21953
name: BCKDHB
constant: false
is encoded by: hsa:594

metaM srtn c
is: CHEBI:350546
boundary condition: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
name: serotonin(1+)
initial concentration: 1.0
is: HMDB00259
has only substance units: false

metaM ps hs m
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
type: Species
initial concentration: 1.0
is: CHEBI:18303
name: ps_hs[m]
initial amount: NaN
has only substance units: false
constant: false

metaR PYRt2m
product: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
fast: false
is described by: ECO:0000000
name: pyruvate mitochondrial transport via proton symport
reactant: MODEL1310110006#
type: Reaction
reversible: true
kinetic law: MODEL1310110006#

metaR RE3347C
is described by: ECO:0000000
name: RE3347
reversible: true
product: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
kinetic law: MODEL1310110006#
is: SBO:0000176
fast: false

metaM pail34p hs c
boundary condition: false
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
is: SBO:0000247
type: Species
is: CHEBI:57658

metaR SUCCOAPET
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaM xoltetrol m
is: HMDB01231
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
type: Species
is: CHEBI:17278
initial concentration: 1.0
constant: false
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_2ed39b77_4b91_4410_a47a_6979618547e2
is encoded by: hsa:94005
constant: false
is encoded by: hsa:10026
name: PIGK:PIGU:PIGT:GPAA1:PIGS
type: Species
has part: Q92643
initial amount: NaN
has part: O43292
has part: Q969N2
is: SBO:0000297
has only substance units: false
has part: Q8NBL9
is encoded by: hsa:128869
boundary condition: true
is encoded by: hsa:8733
is encoded by: hsa:51604
has part: Q9H490
initial concentration: NaN

metaR r1617
product: MODEL1310110006#
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110006#

metaM udp c
type: Species
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58223
name: UDP
boundary condition: false
constant: false
initial amount: NaN
is: C00015
is: HMDB00295

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaM ser L m
name: L-serine
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
has only substance units: false
is: HMDB00187
is: SBO:0000247

metaR r0679
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
type: Reaction
reversible: true
modifier: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
reactant: MODEL1310110006#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_e8b72b8a_ee7f_4a32_8467_c2e77a3840c1
type: Species
name: DGKQ
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1609
has only substance units: false
is: P52824
is: SBO:0000252
boundary condition: true

metaR N2M2NMASNtly
type: Reaction
reactant: MODEL1310110006#
product: MODEL1310110006#
name: n2m2nmasn transport, extracellular to lysosome
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110006#_bea46bb2_58ab_4b0d_a493_29c864359e15
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: P25325
boundary condition: true
is encoded by: hsa:4357
name: MPST

http://identifiers.org/biomodels.db/MODEL1310110006#_8a71d6f5_3b1a_4435_b5a5_ed4eb4f3d521
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
initial amount: NaN
has part: O43924
has part: P18545
constant: false
type: Species
initial concentration: NaN
is: SBO:0000297
has only substance units: false
boundary condition: true
is encoded by: hsa:5147
is encoded by: hsa:5148

metaR r1618
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110006#
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110006#_cf660b7c_f609_4443_9aa9_4d80818ff5c9
type: Species
boundary condition: true
constant: false
initial amount: NaN
name: ADCY2
is: Q71UM8
is encoded by: hsa:108
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_d0277aac_c8cf_4ca6_8568_2b11321e210e
is: Q9NRZ7
name: AGPAT3
boundary condition: true
is encoded by: hsa:56894
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM hista c
initial concentration: 1.0
has only substance units: false
name: histamium
boundary condition: false
initial amount: NaN
is: CHEBI:58432
is: SBO:0000247
is: HMDB00870
constant: false
type: Species
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388

metaR CYTDt
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110006#
modifier: MODEL1310110006#
name: cytidine facilated transport in cytosol
product: MODEL1310110006#
reversible: true
is: SBO:0000185
fast: false

metaR r0464
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
kinetic law: MODEL1310110006#
fast: false
reversible: true
is described by: ECO:0000000
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
reactant: MODEL1310110006#
is: SBO:0000176
type: Reaction
product: MODEL1310110006#

metaM srtn e
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
name: serotonin(1+)
is: CHEBI:350546
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00259
constant: false
type: Species
boundary condition: false

metaM methf m
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial concentration: 1.0
is: CHEBI:57455
name: (6R)-5,10-methenyltetrahydrofolate
type: Species
is: HMDB01354
is: SBO:0000247
boundary condition: false

metaM taur e
is: HMDB00251
notes: FORMULA: C2H7NO3S CHARGE: 0
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: C00245
is: CHEBI:3544
boundary condition: false
name: Taurine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_a34154ee_7e4f_4ba7_ad0a_18a5f1221f4d
is: SBO:0000252
is encoded by: hsa:80025
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: PANK2
type: Species
is: Q6P1K9

metaR FAOXC4C4DCc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_1420c80e_981a_4bd5_92ef_c3e6849b7984
is encoded by: hsa:5152
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: PDE9A
initial concentration: NaN
type: Species
initial amount: NaN

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR r1619
kinetic law: MODEL1310110006#
product: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110006#
modifier: MODEL1310110006#

metaR FAOXC185m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaR ACt2r
product: MODEL1310110006#
fast: false
is described by: ECO:0000000
name: acetate reversible transport via proton symport
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD

metaM r5p c
is: CHEBI:18189
is: HMDB00618
boundary condition: false
initial concentration: 1.0
constant: false
name: alpha-D-Ribose 5-phosphate
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
initial amount: NaN
is: SBO:0000247
type: Species
is: C00117
has only substance units: false

metaM dhlam m
constant: false
has only substance units: false
name: dihydrolipoamide
is: CHEBI:17694
type: Species
is: SBO:0000247
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
initial amount: NaN
initial concentration: 1.0
is: HMDB00985
boundary condition: false

metaR FAOXC184C163x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

metaM abt e
boundary condition: false
is: SBO:0000247
name: L-arabinitol
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:18403
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: HMDB01851

http://identifiers.org/biomodels.db/MODEL1310110006#_92aec9ae_7300_453b_9841_7a68b2d82255
type: Species
initial concentration: NaN
is encoded by: hsa:3033
is: SBO:0000252
is: Q16836
initial amount: NaN
constant: false
has only substance units: false
name: HADH
boundary condition: true

metaR AACOAT
modifier: MODEL1310110006#
is described by: ECO:0000269
kinetic law: MODEL1310110006#
type: Reaction
name: Acetoacetyl-CoA:acetate CoA-transferase
reactant: MODEL1310110006#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.2.1.16
reversible: true

metaM atp x
is: SBO:0000247
constant: false
is: HMDB00538
boundary condition: false
type: Species
initial amount: NaN
is: C00002
is: CHEBI:57299
name: ATP(4-)
has only substance units: false
initial concentration: 1.0

metaM hista e
initial concentration: 1.0
type: Species
name: histamium
initial amount: NaN
is: CHEBI:58432
is: SBO:0000247
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: HMDB00870
has only substance units: false
constant: false
boundary condition: false

metaR EX c101crn
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decenoyl carnitine
type: Reaction

metaM taur c
is: C00245
is: HMDB00251
type: Species
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: Taurine
initial concentration: 1.0
is: CHEBI:3544
notes: FORMULA: C2H7NO3S CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110006#_3577a060_7c81_4144_802d_b8d33c7c5e3e
is: Q02127
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: DHODH
is encoded by: hsa:1723
has only substance units: false
constant: false

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaR AGPAT1
notes: GENE_ASSOCIATION: (10555.1) or (137964.1) or (56895.1) or (56894.2) or (56894.1) or (55326.1) or (10554.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.51 Confidence Level: 4 AUTHORS: NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is described by: ECO:0000000
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.15
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
name: 1-acylglycerol-3-phosphate O-acyltransferase 1
product: MODEL1310110006#
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.51
is: SBO:0000176

metaR r1613
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110006#
reversible: true
type: Reaction

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

metaR TRIODTHYt2
type: Reaction
name: T3 transport via facilitated diffusion
fast: false
reversible: true
modifier: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185

metaR RE1533M
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1533
reactant: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
is described by: ECO:0000000
fast: false
product: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110006#
type: Reaction

metaR FACOAL80i
reactant: MODEL1310110006#
name: fatty-acid--CoA ligase (octanoate)
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110006#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
modifier: MODEL1310110006#
fast: false
is: SBO:0000176
product: MODEL1310110006#
is described by: ECO:0000269

metaM retinal 11 cis c
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: 11-cis-retinal
type: Species
is: HMDB02152
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial amount: NaN
is: CHEBI:16066
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_bd04defe_8204_459c_bb0c_7bb5cf37c5b9
boundary condition: true
initial amount: NaN
is encoded by: hsa:2687
constant: false
is: P36269
type: Species
is: SBO:0000252
name: GGT5
has only substance units: false
initial concentration: NaN

metaM pyr m
boundary condition: false
is: HMDB00243
is: C00022
is: SBO:0000247
initial concentration: 1.0
name: pyruvate
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
has only substance units: false
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/3324
is: CHEBI:15361
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_7fa9801f_ed21_4ee7_b573_c4a1b2884135
type: Species
name: NDUFS6
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q6IBC4
is: SBO:0000252
is encoded by: hsa:4726
constant: false

metaM udp g
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00295
constant: false
has only substance units: false
is: CHEBI:58223
name: UDP(3-)

metaR IDPtn
name: IDP nuclear transport
type: Reaction
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110006#
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110006#
is described by: ECO:0000000

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_7665132a_ba7e_4be1_89d1_f7ee2934da27
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC19A3
is encoded by: hsa:80704
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is: Q9BZV2

metaR LYStm
name: Lysine mitochondrial transport via ornithine carrier
is described by: ECO:0000269
product: MODEL1310110006#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false
type: Reaction
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_c90aa459_f27b_4a92_92dc_3f79b3459174
has only substance units: false
boundary condition: true
is: P00325
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:125
constant: false
name: ADH1B

http://identifiers.org/biomodels.db/MODEL1310110006#_67f3c457_aaa1_487f_a6cc_764fe043415d
initial amount: NaN
type: Species
initial concentration: NaN
name: MPI
boundary condition: true
constant: false
is encoded by: hsa:4351
is: P34949
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_a263e3c1_dc0c_42c6_a649_49f391ff0788
name: ATP1B2
initial amount: NaN
is encoded by: hsa:482
type: Species
has only substance units: false
is: P14415
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252

metaM 4nph e
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: HMDB01232
type: Species
initial amount: NaN
initial concentration: 1.0
name: 4-nitrophenolate
is: CHEBI:57917

metaR GLCAASE4ly
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110006#
reversible: false
reactant: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.31
product: MODEL1310110006#
name: beta-glucuronidase, lysosomal

metaR FRDPtr
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
type: Reaction
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
reactant: MODEL1310110006#
fast: false

metaR r1614
modifier: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR PROSTGI2t
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000269
name: Prostaglandin I2 transport

http://identifiers.org/biomodels.db/MODEL1310110006#_f7c11199_026d_4587_8095_8fe517c33ae6
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:79623
boundary condition: true
name: GALNT14
initial concentration: NaN
is: Q96FL9
is: SBO:0000252
type: Species

metaM thexddcoa m
boundary condition: false
constant: false
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
name: trans7,10-hexadecadienoylcoa
is: SBO:0000247
is: HMDB02288
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_b48f49a2_2d13_420b_baa9_070fbb9365de
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:3028
has only substance units: false
constant: false
initial concentration: NaN
name: HSD17B10
is: Q99714

metaM abt c
is: CHEBI:18403
constant: false
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
type: Species
is: HMDB01851
initial concentration: 1.0
name: L-arabinitol
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaM retinol cis 13 c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13-
type: Species
boundary condition: false
has only substance units: false
constant: false
is: HMDB06217
initial concentration: 1.0
initial amount: NaN
name: 13-cis-retinol
is: CHEBI:45479
is: SBO:0000247

metaR RE1807C
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
kinetic law: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
name: RE1807
reactant: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000
reversible: true

metaR EX c5dc
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaM tmndnccoa c
is: SBO:0000247
name: timnodonyl coenzyme A
has only substance units: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
is: HMDB06514
boundary condition: false
initial concentration: 1.0

metaM C05279 m
type: Species
name: trans,cis-Lauro-2,6-dienoyl-CoA
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB11123
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:28387
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279

metaM CE5118 m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57923
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
type: Species

metaR r1615
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110006#
is: SBO:0000185

metaM udp e
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
has only substance units: false
name: UDP(3-)
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00295

metaM ppi n
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
name: diphosphate(3-)
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:33019
initial concentration: 1.0
constant: false
type: Species

metaR PTDCACRNCPT1
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
name: carnitine fatty-acyl transferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110006#
is described by: ECO:0000269
product: MODEL1310110006#

metaR STCOAtx
reversible: true
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
fast: false
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
reactant: MODEL1310110006#
is described by: ECO:0000000

metaR FAOXC14C12x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_a830b296_2a92_493b_9f3f_e75348d29555
type: Species
boundary condition: true
is: P35475
is encoded by: hsa:3425
constant: false
has only substance units: false
is: SBO:0000252
name: IDUA
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_e3346095_febf_4c60_bcaa_72e4774e5689
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
name: SLC9A4
type: Species
is: SBO:0000252
is: Q6AI14
is encoded by: hsa:389015

metaR CYSTS
type: Reaction
notes: GENE_ASSOCIATION: (875.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 4 AUTHORS: PMID:681363,PMID:9790750 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110006#
is: SBO:0000176
product: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
name: cystathionine beta-synthase
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.22
modifier: MODEL1310110006#

metaR r0899
product: MODEL1310110006#
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
name: Amino acid transporter ATB0+ Facilitated diffusion
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110006#_4b08efaa_1d45_494b_b23b_f80e696d0260
constant: false
is: G3V0F6
is: SBO:0000252
is encoded by: hsa:8525
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
name: DGKZ

metaR CITRtm
name: citrulline mitochondrial transport via proton antiport
type: Reaction
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110006#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110006#

metaM nadph m
is: CHEBI:57783
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: HMDB00221
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005

metaR CDPDAGtm
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is described by: ECO:0000000
product: MODEL1310110006#
name: intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

metaR r1616
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110006#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110006#
reversible: true
is described by: ECO:0000000

metaR PTDCACRNCPT2
kinetic law: MODEL1310110006#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
fast: false
reactant: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
name: pentadecanoate transport into the mitochondria
is version of: http://identifiers.org/ec-code/2.3.1.21

metaM ps hs e
is: SBO:0000247
is: CHEBI:18303
constant: false
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
name: phosphatidylserine
initial concentration: 1.0

metaR DPCOAPPe
fast: false
is: SBO:0000176
name: Pyrophasphatase (dephospho-CoA, extracellular)
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reversible: false
reactant: MODEL1310110006#
is described by: ECO:0000134
kinetic law: MODEL1310110006#
product: MODEL1310110006#

metaR TALA
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.2.1.2
reactant: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
type: Reaction
name: transaldolase
modifier: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
fast: false

metaM 3mox4hoxm c
type: Species
name: 3-Methoxy-4-hydroxymandelate
initial amount: NaN
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
constant: false
is: SBO:0000247
is: HMDB00291
initial concentration: 1.0
is: CHEBI:27622
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_abd2a4e8_f688_4486_9839_727f304383db
is: E5KNH5
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: NDUFV1
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4723

metaM ppi m
is: SBO:0000247
constant: false
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
name: Diphosphate
is: HMDB00250
initial amount: NaN
has only substance units: false
is: CHEBI:33019
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_d9dc84db_8fa5_491f_8e6b_29055429a113
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: _AA526438_1_m
is: SBO:0000252
is encoded by: hsa:AA526438
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_edfcd691_59cb_491e_887d_d66e6d4957e1
is encoded by: hsa:4728
is: SBO:0000252
has only substance units: false
type: Species
is: O00217
constant: false
initial concentration: NaN
name: NDUFS8
boundary condition: true
initial amount: NaN

metaM succ x
is: CHEBI:30031
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: Succinate
initial concentration: 1.0
is: C00042
type: Species

metaR ACt2m
kinetic law: MODEL1310110006#
is: SBO:0000185
reversible: true
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110006#
type: Reaction
fast: false
name: acetate mitochondrial transport via proton symport

metaM ak2lgchol hs c
initial amount: NaN
is: C04317
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
initial concentration: 1.0
is: SBO:0000247
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
boundary condition: false
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/6975
constant: false

metaM ala L m
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00161
is: CHEBI:16977
name: L-alanine

http://identifiers.org/biomodels.db/MODEL1310110006#_61e9279b_4d41_4c87_b0f3_47c32c4dc10e
initial amount: NaN
is encoded by: hsa:5169
constant: false
has only substance units: false
initial concentration: NaN
is: Q308M7
type: Species
name: ENPP3
boundary condition: true
is: SBO:0000252

metaR AG13T15g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110006#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176

metaR LPS4e
name: phospholipase
notes: GENE_ASSOCIATION: (50487.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10713052 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
type: Reaction
modifier: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.4

metaR DOLPMT1 Ler
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.258
product: MODEL1310110006#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
type: Reaction
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110006#
reactant: MODEL1310110006#

metaR GALASE4ly
name: beta-galactosidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110006#
reversible: false
reactant: MODEL1310110006#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110006#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR r0672
fast: false
is: SBO:0000176
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
is described by: ECO:0000000
reversible: true

metaR FAOXC184C163m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_eebfba74_5cfa_4c63_b6b7_bf930134a0cd
is: SBO:0000252
is encoded by: hsa:51109
initial amount: NaN
name: RDH11
boundary condition: true
is: B4DDW0
initial concentration: NaN
has only substance units: false
type: Species
constant: false

metaM udp l
has only substance units: false
name: UDP(3-)
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:58223
boundary condition: false
initial concentration: 1.0
is: HMDB00295
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

http://identifiers.org/biomodels.db/MODEL1310110006#_1334b7c7_f1aa_40ae_8aa2_742198fe00ec
is: SBO:0000252
boundary condition: true
name: SLC24A4
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:123041

metaM CE2418 m
is: HMDB11123
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
is: SBO:0000247
is: CHEBI:28387
initial concentration: 1.0
has only substance units: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
boundary condition: false
constant: false
initial amount: NaN
type: Species

metaR r0671
is: SBO:0000176
product: MODEL1310110006#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.22
modifier: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2717.1) or (6173.1) SUBSYSTEM: CoA synthesis EC Number: 6.3.2.5 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:12906824,PMID:15893380 NOTES:
fast: false
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
name: (R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5

metaM sphings c
is: SBO:0000247
initial amount: NaN
is: CHEBI:57756
constant: false
name: sphingosine(1+)
initial concentration: 1.0
is: HMDB00252
boundary condition: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
type: Species
has only substance units: false

metaM ser L e
is: HMDB00187
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
name: L-serine
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM CE5788 e
initial amount: NaN
name: kinetensin 1-7
constant: false
is: CHEBI:27485
is: HMDB02710
is: SBO:0000247
type: Species
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR r2338
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
kinetic law: MODEL1310110006#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction

metaM ksii core2 pre9 g
initial amount: NaN
is: CHEBI:28067
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 9
boundary condition: false
constant: false
notes: FORMULA: C75H120N6O59S2X CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110006#_8c57fda6_05f3_4a92_a851_80175184190b
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6240
is: P23921
name: RRM1

metaM dolp U r
constant: false
name: dolichyl phosphate(2-)
is: CHEBI:57683
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
has only substance units: false

metaM ak2lgchol hs e
has only substance units: false
initial concentration: 1.0
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
constant: false
is: C04317
is: http://identifiers.org/pubchem.compound/6975
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317

metaR S6T1g
fast: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
is described by: ECO:0000000
product: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
is: SBO:0000176

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_78cbf3be_e0b6_4b0a_a846_6890ee1f44e9
constant: false
is encoded by: hsa:AF116616
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
name: _AF116616_1_m
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_2d1c795d_a01b_4e1a_968e_2380439566ca
constant: false
is encoded by: hsa:2584
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: P51570
boundary condition: true
type: Species
has only substance units: false
name: GALK1

metaR q10tm
type: Reaction
fast: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110006#
name: transport of ubiquinone into mitochondria
is: SBO:0000185
product: MODEL1310110006#

metaR PROSTGH2t
name: Prostaglandin H2 transport
product: MODEL1310110006#
reversible: true
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reactant: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
type: Reaction

metaM octdececrn c
constant: false
is: HMDB06351
boundary condition: false
notes: FORMULA: C25H47NO4 CHARGE: 0
initial concentration: 1.0
type: Species
has only substance units: false
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
is: SBO:0000247
initial amount: NaN

metaR DALAt2r
name: D-alanine transport via proton symport
modifier: MODEL1310110006#
is described by: ECO:0000304
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
reversible: true

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_40faa725_e5cf_4624_ae08_b61b95c13317
is: Q9Y4C5
has only substance units: false
is encoded by: hsa:9435
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: CHST2
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_e5a8a11a_f122_48e9_9760_37fbe4a0cf1a
is: Q7Z7B1
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PIGW
boundary condition: true
type: Species
constant: false
is encoded by: hsa:284098
is: SBO:0000252

metaM ser L c
boundary condition: false
name: L-serine
is: HMDB00187
is: CHEBI:17115
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068

http://identifiers.org/biomodels.db/MODEL1310110006#_5b2b0565_9608_434f_bdea_a8b8544dda4e
boundary condition: true
name: GLS2
is encoded by: hsa:27165
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR ARGtm
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110006#
product: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
name: arginine mitochondrial transport via ornithine carrier

metaR PSFLIPm
is: SBO:0000185
name: phosphatidylserine flippase
is version of: http://identifiers.org/ec-code/3.6.3.1
modifier: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ

http://identifiers.org/biomodels.db/MODEL1310110006#_57ce2100_bd1b_4c60_9569_d97a7c94b2d6
is: P33121
has only substance units: false
initial amount: NaN
is encoded by: hsa:2180
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: ACSL1

metaR r2335
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110006#
kinetic law: MODEL1310110006#

metaM ppi c
is: CHEBI:0
type: Species
constant: false
has only substance units: false
is: C00013
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3
boundary condition: false
initial amount: NaN
name: Diphosphate
is: HMDB00250

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_e6825f4c_8f28_4d46_bfdc_642cca3f9c13
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: Q9UHW9
is encoded by: hsa:9990
name: SLC12A6
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR MI134P4P
reversible: false
is described by: ECO:0000000
product: MODEL1310110006#
type: Reaction
is: SBO:0000176
fast: false
name: inositol-1,3,4-trisphosphate 4-phosphatase
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_7f85491d_7789_416c_a144_66d62a0a93d2
initial concentration: NaN
is encoded by: hsa:5538
initial amount: NaN
has only substance units: false
name: PPT1
is: Q6FGQ4
type: Species
boundary condition: true
is: SBO:0000252
constant: false

metaM ksi pre6 g
notes: FORMULA: C107H174N7O80SX CHARGE: -2
constant: false
is: HMDB00175
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 6
is: SBO:0000247
is: CHEBI:58053
is: C00130
boundary condition: false
type: Species
has only substance units: false

metaR GLNLASEer
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
reversible: true
reactant: MODEL1310110006#
product: MODEL1310110006#
kinetic law: MODEL1310110006#
name: gluconolactonase, endoplasmic reticulum
is described by: ECO:0000000
type: Reaction

metaM oh1 c
is: HMDB01039
name: hydroxide ion
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: C01328
notes: FORMULA: HO CHARGE: -1
has only substance units: false
boundary condition: false

metaR HSD17B4x
type: Reaction
fast: false
reactant: MODEL1310110006#
is described by: ECO:0000269
name: hydroxysteroid (17-beta) dehydrogenase 4
is: SBO:0000176
reversible: false
product: MODEL1310110006#
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use

metaM ksi pre21 g
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00175
is: C00130
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 21
type: Species
constant: false

metaM hs deg18 l
is: HMDB01352
name: heparan sulfate, degradation product 18
constant: false
initial amount: NaN
is: CHEBI:17180
type: Species
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_2a3a66d3_9142_4b85_8b3d_3f44cd5a3a53
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:23428
constant: false
boundary condition: true
is: Q9UHI5
type: Species
name: SLC7A8

metaR RE2998M
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
name: RE2998
reversible: false
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110006#_1b484818_0bdb_44cb_a1d0_cae68494b833
is encoded by: hsa:4716
has part: Q6FG42
is: SBO:0000297
is encoded by: hsa:374291
has part: Q7GXY9
is encoded by: hsa:4723
has part: B7Z792
has part: P56181
is encoded by: hsa:4714
is encoded by: hsa:4724
has part: O95167
has part: P03897
has part: Q9P0J0
has part: C9JT23
is encoded by: hsa:4537
is encoded by: hsa:4707
is encoded by: hsa:4717
is encoded by: hsa:4700
initial concentration: NaN
has part: P19404
is encoded by: hsa:4708
is encoded by: hsa:4697
has part: Q549M5
has part: O43674
has part: O75438
has part: O95139
has part: O43181
has part: O95169
has part: H7C5B8
boundary condition: true
has part: O43677
is encoded by: hsa:4725
has part: A8K761
has part: Q16795
has part: B1AM93
is encoded by: hsa:4704
is encoded by: hsa:4726
is encoded by: hsa:7991
has part: Q6IBB5
has part: P28331
has part: P17568
is encoded by: hsa:4701
is encoded by: hsa:4711
is encoded by: hsa:4539
is encoded by: hsa:4709
is encoded by: hsa:4719
is encoded by: hsa:4702
is encoded by: hsa:4535
has only substance units: false
has part: O75251
is encoded by: hsa:4710
is encoded by: hsa:4720
has part: Q85KV6
has part: Q16718
has part: E5KNH5
is encoded by: hsa:4538
is encoded by: hsa:55967
is encoded by: hsa:4718
is encoded by: hsa:4728
is encoded by: hsa:4540
has part: O00483
has part: P03915
has part: O00217
has part: O75489
is encoded by: hsa:4694
is encoded by: hsa:4698
has part: O95299
has part: O95168
is encoded by: hsa:51079
is encoded by: hsa:4705
is encoded by: hsa:4715
has part: Q13454
type: Species
has part: Q9Y6M9
is encoded by: hsa:4713
constant: false
is encoded by: hsa:4731
is encoded by: hsa:4729
has part: P56556
is encoded by: hsa:4712

metaR ECOAH9m
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110006#
reversible: true
is: SBO:0000176
modifier: MODEL1310110006#
product: MODEL1310110006#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is described by: ECO:0000304
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_661f5a49_31d4_4d68_8d4f_51b0658956fa
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:AI440329
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
name: _AI440329_1_r

http://identifiers.org/biomodels.db/MODEL1310110006#_039e9cc3_a31a_41a3_9b3c_b4b2631dd47f
boundary condition: true
is encoded by: hsa:5288
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: O75747
type: Species
constant: false
name: PIK3C2G
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_feaa621a_2ce7_4673_b9cf_bc07bf74b3f4
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:875
name: CBS
constant: false
initial concentration: NaN
is: Q9NTF0
initial amount: NaN
boundary condition: true

metaR r2334
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reversible: true
reactant: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction

metaR G14T20g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
fast: false
reversible: false
modifier: MODEL1310110006#
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110006#

metaM ksi deg30 l
constant: false
initial concentration: 1.0
is: HMDB00143
name: keratan sulfate I, degradation product 30
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:12936
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
type: Species
initial amount: NaN

metaM tymsf c
is: SBO:0000247
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
type: Species
name: Tyramine O-sulfate
constant: false
is: HMDB06409
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM prpncoa m
constant: false
initial amount: NaN
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
boundary condition: false
is: CHEBI:57367
initial concentration: 1.0
is: HMDB02307
type: Species
has only substance units: false
is: SBO:0000247
name: acryloyl-CoA(4-)

metaR r0142
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
kinetic law: MODEL1310110006#
is: SBO:0000176
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.6.1.5

http://identifiers.org/biomodels.db/MODEL1310110006#_5339beda_7887_4f69_81ae_ffd31d683caf
initial amount: NaN
constant: false
name: ALDH1A3
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P47895
is encoded by: hsa:220
type: Species

metaM tridcoa m
constant: false
is: HMDB13109
initial amount: NaN
has only substance units: false
notes: FORMULA: C34H56N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
name: tridecanoylcoa

http://identifiers.org/biomodels.db/MODEL1310110006#_d015eaca_b81e_4549_a682_7689f426722f
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: GPX1
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2876
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_d31be54d_eb90_465b_a727_62a7e6fe9b3d
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
name: FADS2
is: SBO:0000252
constant: false
is: O95864
is encoded by: hsa:9415
initial concentration: NaN

metaM prpp c
is: C00119
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58017
is: HMDB00280
is: SBO:0000247
boundary condition: false
type: Species
name: 5-Phospho-alpha-D-ribose 1-diphosphate
has only substance units: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
constant: false

metaR CYTK2n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reactant: MODEL1310110006#
modifier: MODEL1310110006#
product: MODEL1310110006#
reversible: true
name: cytidylate kinase (dCMP),nuclear
kinetic law: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM nadph c
is: C00005
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
initial amount: NaN
is: HMDB00221
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species
constant: false
is: SBO:0000247
is: CHEBI:57783
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_23b9039c_cf8f_4a52_927b_a9de61fe839c
type: Species
is encoded by: hsa:6567
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: SLC16A2
is: P36021
constant: false
initial amount: NaN
boundary condition: true

metaR FAOXC181C161m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_bf6e0034_4f73_4fdf_b645_222580f9f0a8
initial amount: NaN
is encoded by: hsa:84812
name: PLCD4
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q9BRC7
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_4646ce26_00c0_4eb7_81be_73e690305d0c
initial concentration: NaN
is: Q99519
is encoded by: hsa:4758
constant: false
has only substance units: false
is: SBO:0000252
name: NEU1
type: Species
boundary condition: true
initial amount: NaN

metaR FAOXC61C4x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)x
type: Reaction

metaR 3DSPHR
reactant: MODEL1310110006#
is: SBO:0000176
modifier: MODEL1310110006#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.1.1.102
reversible: false
type: Reaction
name: 3-Dehydrosphinganine reductase
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110006#_67dd7f93_c758_481b_b535_45f65d3327f7
has part: P11177
boundary condition: true
constant: false
type: Species
name: DLAT:DLD:PDHA2:PDHB:PDHX
has part: P29803
initial amount: NaN
is encoded by: hsa:5161
is: SBO:0000297
is encoded by: hsa:5162
is encoded by: hsa:1737
initial concentration: NaN
has part: Q86YI5
has only substance units: false

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM udp n
name: UDP(3-)
is: HMDB00295
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223

metaM ppi e
name: Diphosphate
constant: false
type: Species
is: SBO:0000247
is: C00013
has only substance units: false
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial amount: NaN
boundary condition: false
is: CHEBI:33019
is: HMDB00250

metaM oh1 e
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
name: hydroxide ion
initial concentration: 1.0
is: C01328
type: Species
is: HMDB01039
notes: FORMULA: HO CHARGE: -1

metaR r0355
product: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.3
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
fast: false
is: SBO:0000176

metaR S3TASE2ly
is described by: ECO:0000000
reactant: MODEL1310110006#
reversible: true
type: Reaction
name: N-acetylglucosamine-3-sulfatase, lysosomal
kinetic law: MODEL1310110006#
fast: false
is: SBO:0000176
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110006#_1051df4c_85ee_4916_8bdc_3d7587aaa36d
is: B3KT70
boundary condition: true
constant: false
type: Species
is encoded by: hsa:80201
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: HKDC1

metaR PItx
product: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000
name: Phosphate transporter, peroxisome
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110006#_524135a5_506b_4459_abb6_7a04bb19db17
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000297
has part: P54709
is encoded by: hsa:483
name: ATP1A1:ATP1B3
is encoded by: hsa:476
has only substance units: false
initial amount: NaN
has part: B7Z3U6

http://identifiers.org/biomodels.db/MODEL1310110006#_7a87c2c4_468b_47b1_90e3_cfc72682e044
is: Q14642
type: Species
boundary condition: true
is: SBO:0000252
name: INPP5A
constant: false
is encoded by: hsa:3632
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR PYRt2r
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
fast: false
kinetic law: MODEL1310110006#
reversible: true
product: MODEL1310110006#
reactant: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
name: pyruvate reversible transport via proton symport
is described by: ECO:0000269
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110006#_e8c59c03_9a8b_4485_b091_29fb9a46f64d
initial amount: NaN
has only substance units: false
is: Q53HM1
type: Species
name: UCKL1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:54963
constant: false

metaR PAIL45P HStn
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110006#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110006#
product: MODEL1310110006#

metaM tymsf e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
has only substance units: false
name: Tyramine O-sulfate
constant: false
type: Species
initial amount: NaN
is: HMDB06409

metaR ARACHDt2
type: Reaction
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110006#
is described by: ECO:0000000
reversible: true
name: fatty acid transport via diffusion
fast: false
reactant: MODEL1310110006#
is: SBO:0000185

metaM 5aop m
has only substance units: false
is: CHEBI:17549
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: C00430
is: SBO:0000247
name: 5-Amino-4-oxopentanoate
boundary condition: false
is: HMDB01149
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430

metaR EX tetdece1crn
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_0087214b_949e_4e45_b1ea_92a0301bbe35
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:8733
has only substance units: false
is: O43292
is: SBO:0000252
name: GPAA1

metaR r1721
product: MODEL1310110006#
is: SBO:0000185
modifier: MODEL1310110006#
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110006#
fast: false

metaM prpp e
initial amount: NaN
has only substance units: false
is: CHEBI:58017
is: HMDB00280
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
constant: false

metaM urcan c
boundary condition: false
name: Urocanate
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
is: SBO:0000247
initial amount: NaN
is: CHEBI:17771
is: C00785
type: Species
initial concentration: 1.0
constant: false
is: HMDB00301
has only substance units: false

metaR r0354
kinetic law: MODEL1310110006#
type: Reaction
fast: false
reactant: MODEL1310110006#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.2.1.3
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is: SBO:0000176
product: MODEL1310110006#
reversible: false

metaR ADNCYC
is: SBO:0000176
name: adenylate cyclase
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.6.1.1
product: MODEL1310110006#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
reversible: false

metaR PI4PLC
modifier: MODEL1310110006#
reversible: false
product: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol 4-phosphate phospholipase C
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
fast: false

metaR B3GNT33g
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110006#
is: SBO:0000176
modifier: MODEL1310110006#
is described by: ECO:0000269
fast: false
product: MODEL1310110006#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
kinetic law: MODEL1310110006#

metaR HDCACBP
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_249c5689_0cf1_4b48_bf9f_ee1117e14119
has part: Q7L2M7
has only substance units: false
type: Species
name: PFKL:PFKP
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:5211
initial amount: NaN
is: SBO:0000297

metaR r0784
reactant: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_da77c40d_5267_4040_aa11_1d9758944f1a
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:23007
initial amount: NaN
is: SBO:0000252
is: Q4KWH8
has only substance units: false
type: Species
name: PLCH1

metaR THBPT4ACAMDASE
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.96
reversible: false
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110006#
product: MODEL1310110006#
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
is described by: ECO:0000269

metaM galside hs c
is: CHEBI:12947
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
is: SBO:0000247
name: D-galactosyl-N-acylsphingosine
has only substance units: false
boundary condition: false
constant: false

metaR URATEt
fast: false
product: MODEL1310110006#
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
type: Reaction
name: urate export from cytosol
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110006#_091a870b_df1a_4345_9ca4_879acfe103b4
type: Species
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:1603
name: DAD1
is: Q53G02
has only substance units: false
is: SBO:0000252

metaM mgacpail hs r
is: CHEBI:7896
constant: false
has only substance units: false
initial amount: NaN
is: C00249
initial concentration: 1.0
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
is: HMDB00220
boundary condition: false
type: Species

metaM acngalgbside hs g
initial amount: NaN
name: sialyl galactosylgloboside
is: SBO:0000247
has only substance units: false
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
is: HMDB03406
initial concentration: 1.0
boundary condition: false
is: CHEBI:16523
constant: false
type: Species

metaM fuc L c
is: CHEBI:18287
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
is: HMDB00174
has only substance units: false
is: SBO:0000247
type: Species
name: L-fucose
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false

metaM decdicrn e
notes: FORMULA: C17H29NO4 CHARGE: 0
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
name: decadienoyl carnitine
is: HMDB13325

metaM cs e l
type: Species
constant: false
has only substance units: false
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
boundary condition: false
is: HMDB02183
initial concentration: 1.0
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
is: SBO:0000247
is: CHEBI:36005
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_9f6550ff_75f3_4761_923f_639e13960fdc
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:N63787
name: _N63787_1_c

metaM leuktrA4 c
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial concentration: 1.0
boundary condition: false
type: Species
name: leukotriene A4(1-)
initial amount: NaN
is: HMDB01337
is: SBO:0000247
is: CHEBI:57463
has only substance units: false

metaR PGLYCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
name: phosphatidylglycerol transport
is described by: ECO:0000269
product: MODEL1310110006#
is: SBO:0000185
reversible: true
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
type: Reaction

metaR CYTK10n
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
name: cytidylate kinase (CMP,dGTP),nuclear
is: SBO:0000176
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110006#_b3fbefd1_c46f_4447_9184_a7445f7b9ae9
has only substance units: false
name: B3GNT8
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:374907
is: Q7Z7M8
type: Species
constant: false
initial concentration: NaN
boundary condition: true

metaR MI1PS
product: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/5.5.1.4
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
name: myo-Inositol-1-phosphate synthase
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110006#
reversible: false
fast: false

metaM c101crn e
is: SBO:0000247
name: decenoyl carnitine
boundary condition: false
has only substance units: false
notes: FORMULA: C17H31NO4 CHARGE: 0
is: HMDB13205
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN

metaR UREAtm
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (366.1) SUBSYSTEM: Urea cycle EC Number: Confidence Level: 2 AUTHORS: PMID:12096044,PMID:16126913,PMID:9733774 NOTES:JLR SAB m
modifier: MODEL1310110006#
name: Urea transport via diffusion
fast: false
reactant: MODEL1310110006#
is: SBO:0000185
product: MODEL1310110006#
reversible: true
is described by: ECO:0000304
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_d7297916_442a_43e6_9289_40a0e963f560
is: Q13630
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:7264
boundary condition: true
has only substance units: false
name: TSTA3
initial amount: NaN

metaR r0782
reversible: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:
name: GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaM ksi pre5 g
boundary condition: false
is: CHEBI:28067
is: SBO:0000247
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 5
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C101H164N7O75SX CHARGE: -2

metaR r2344
reversible: true
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
type: Reaction
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR EX retinol 9 cis LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-cis-retinol exchange
type: Reaction

metaR FAOXC14C12m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaM fuc L e
is: SBO:0000247
is: HMDB00174
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
type: Species
has only substance units: false
initial concentration: 1.0
name: L-fucose
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:18287

metaR RE2269E
fast: false
is version of: http://identifiers.org/ec-code/3.4.21.39
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reversible: true
is: SBO:0000176
type: Reaction
reactant: MODEL1310110006#
product: MODEL1310110006#
name: RE2269
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_2c0bf71a_dc8d_4f7d_80f2_12bb663cf064
name: _AI769281_1_e
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI769281
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

metaM succ m
name: Succinate
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:30031
is: HMDB00254
is: SBO:0000247
has only substance units: false
is: C00042

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR r0783
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_e997a9d5_1d18_4597_a4e8_019da7f1e01e
type: Species
initial amount: NaN
is encoded by: hsa:4191
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is: P40926
name: MDH2
initial concentration: NaN

metaM dcamp c
type: Species
is: CHEBI:57567
initial amount: NaN
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
name: N6-(1,2-Dicarboxyethyl)-AMP
is: SBO:0000247
is: C03794
initial concentration: 1.0
is: HMDB00536
has only substance units: false
boundary condition: false
constant: false

metaM prostge1 c
is: HMDB01442
type: Species
name: prostaglandin E1(1-)
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:57397
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_694685e6_bd7b_466f_860c_4ad2afbf81fe
is encoded by: hsa:224
type: Species
is: P51648
initial concentration: NaN
initial amount: NaN
name: ALDH3A2
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252

metaM leuktrA4 e
initial concentration: 1.0
initial amount: NaN
is: HMDB01337
constant: false
is: CHEBI:57463
name: leukotriene A4(1-)
type: Species
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_7225de85_6744_4921_ad5d_b3d9fa1d536a
constant: false
has part: D6RDW3
is encoded by: hsa:2982
has only substance units: false
is: SBO:0000297
is encoded by: hsa:2974
boundary condition: true
name: GUCY1B2:GUCY1A3
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_47314a22_2a8d_4570_b045_cd4896f38cc0
initial amount: NaN
has only substance units: false
boundary condition: true
name: SLC25A26
is encoded by: hsa:115286
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaR FRUt4
kinetic law: MODEL1310110006#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110006#
name: D-fructose transport via sodium cotransport
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110006#
product: MODEL1310110006#

metaR NADPtxu
is described by: ECO:0000000
is: SBO:0000185
reversible: false
reactant: MODEL1310110006#
product: MODEL1310110006#
name: NADP transporter, peroxisome
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
fast: false
kinetic law: MODEL1310110006#

metaR BHBtm
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
is described by: ECO:0000000
product: MODEL1310110006#
reactant: MODEL1310110006#
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
is: SBO:0000185
kinetic law: MODEL1310110006#

metaR EX hexc LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexacosanoate (n-C26:0) exchange
type: Reaction

metaR r0788
modifier: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
fast: false
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103

metaR r0360
reactant: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.16
is: SBO:0000176
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
modifier: MODEL1310110006#
type: Reaction
reversible: false
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: Glycolysis / Glyconeogenesis EC:2.7.1.1

http://identifiers.org/biomodels.db/MODEL1310110006#_82964cf2_d0eb_4f9a_8e0a_602d47eae2e5
has only substance units: false
is: Q13370
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: PDE3B
is encoded by: hsa:5140
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_58d0496c_8e7d_4b73_82b6_3b88732c2405
is: P41247
name: PNPLA4
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8228
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_877f54e6_1296_49c6_96a1_a11e57e5ed06
initial amount: NaN
is encoded by: hsa:4722
type: Species
has only substance units: false
is: O75489
is: SBO:0000252
constant: false
boundary condition: true
name: NDUFS3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_06b01cb1_946c_4c58_91be_352b74c2b302
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:100128062
initial amount: NaN
has only substance units: false
name: _100128062_1_m
is: SBO:0000252
boundary condition: true

metaR NCNt
name: Na+/Ca2+-NH4+ exchange
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000269
modifier: MODEL1310110006#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110006#

metaM c101crn c
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C17H31NO4 CHARGE: 0
has only substance units: false
is: HMDB13205
initial concentration: 1.0
type: Species
name: decenoyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110006#_c363e38b_ee96_40c0_9f85_05f0fe6bfa3c
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:AI191472
constant: false
type: Species
name: _AI191472_1_c

metaR CYOR u10m
kinetic law: MODEL1310110006#
reversible: false
product: MODEL1310110006#
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.5.1.92
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
modifier: MODEL1310110006#
name: ubiquinol-6 cytochrome c reductase, Complex III
is: SBO:0000185
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000134

metaM ca2 c
is: SBO:0000247
initial concentration: 1.0
name: calcium(2+)
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:29108
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
has only substance units: false
is: HMDB00464

metaR RE3269C
kinetic law: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.1.3.48
name: RE3269
reversible: true
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
is described by: ECO:0000000
reactant: MODEL1310110006#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_7c933285_6c73_4421_a52b_2ae149b68690
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:28232
is: SBO:0000252
is: Q9UIG8
name: SLCO3A1
type: Species
initial concentration: NaN
constant: false

metaR RE3005M
name: RE3005
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110006#
is: SBO:0000176
reversible: true
product: MODEL1310110006#
type: Reaction
fast: false
modifier: MODEL1310110006#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110006#_a871a31d_89f3_48a1_aadc_0ca4df71ad37
constant: false
name: SLC28A1
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: Q96PL7
is encoded by: hsa:9154

metaM galside hs g
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
type: Species
is: CHEBI:12947
initial concentration: 1.0
name: D-galactosyl-N-acylsphingosine
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_4ca0c4c4_b5fc_4aed_b36e_9d4772469c97
has only substance units: false
is: SBO:0000252
name: ESCO2
is encoded by: hsa:157570
is: Q56NI9
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_501da779_b9a5_4b48_8861_cc220fbb3020
is encoded by: hsa:2645
constant: false
initial amount: NaN
is: P35557
name: GCK
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species

metaR r0789
reversible: true
reactant: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
kinetic law: MODEL1310110006#
fast: false
is described by: ECO:0000000

metaR HMGCOASi
modifier: MODEL1310110006#
name: Hydroxymethylglutaryl CoA synthase (ir)
reversible: false
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
type: Reaction
product: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.3.10
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110006#

metaM ksi deg37 l
constant: false
type: Species
notes: FORMULA: C62H104N4O46 CHARGE: 0
boundary condition: false
name: keratan sulfate I, degradation product 37
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01354
has only substance units: false
is: CHEBI:57455

metaM HC01603 c
boundary condition: false
initial concentration: 1.0
is: CHEBI:57454
type: Species
name: 10-Formyltetrahydrofolate
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: C00234
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234

metaR r0139
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
modifier: MODEL1310110006#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.2.2
is: SBO:0000176
product: MODEL1310110006#
fast: false
reactant: MODEL1310110006#

metaR PAIL HStn
name: phosphatidylinositol nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110006#
reversible: true
fast: false

metaR FRDPtc
type: Reaction
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reversible: true
product: MODEL1310110006#
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_9b3522db_9809_4cf6_ae7e_d1d3161404c5
has only substance units: false
type: Species
is encoded by: hsa:30
boundary condition: true
constant: false
initial concentration: NaN
name: ACAA1
is: SBO:0000252
initial amount: NaN
is: Q96CA6

metaM prostge1 e
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
name: prostaglandin E1(1-)
is: SBO:0000247
is: HMDB01442
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: CHEBI:57397

metaM ksi deg15 l
initial amount: NaN
is: CHEBI:12936
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C160H257N11O140S8 CHARGE: -8
is: HMDB00143
boundary condition: false
is: SBO:0000247
name: keratan sulfate I, degradation product 15

metaM g1p c
initial concentration: 1.0
is: SBO:0000247
is: C00103
name: D-Glucose 1-phosphate
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
is: CHEBI:58601
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01586

metaR 4HPRO LTte
is described by: ECO:0000134
reactant: MODEL1310110006#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of trans-4-hydroxy-L-proline

metaM ca2 e
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
name: calcium(2+)
boundary condition: false
type: Species
is: CHEBI:29108
is: HMDB00464
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076

metaM pram c
initial amount: NaN
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
is: SBO:0000247
is: CHEBI:58681
is: C03090
name: 5-Phospho-beta-D-ribosylamine
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB01128
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_398f0124_0cc5_4c73_8dc9_3e3748b50a72
is: P36269
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
name: GGT5
initial concentration: NaN
is encoded by: hsa:2687

metaR PItn
product: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
reversible: true
fast: false
name: phosphate transport, nuclear
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_fd04db33_eb3f_4947_9d1f_bbd53de90257
name: PIK3CD:PIK3R1
type: Species
initial concentration: NaN
is encoded by: hsa:5295
has part: E7EX19
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000297

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_682595f5_ac94_4005_8179_6293e7fb0aae
boundary condition: true
name: _AI345944_1_m
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:AI345944

metaM 3hdcoa c
boundary condition: false
is: HMDB13325
name: (S)-3-Hydroxydecanoyl-CoA
constant: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR GASNASE3ly
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.5.1.26
name: glycosylasparaginase, lysosomal
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110006#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110006#

metaR r0787
fast: false
is: SBO:0000176
product: MODEL1310110006#
is described by: ECO:0000000
modifier: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
type: Reaction
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
kinetic law: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.1

metaR FAOXC184x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

metaM ksi pre32 g
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 32
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C227H362N16O192S10X CHARGE: -11

metaR MI1PP
is: SBO:0000176
reversible: false
product: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
modifier: MODEL1310110006#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.25
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
reactant: MODEL1310110006#
name: myo-inositol 1-phosphatase

metaR TPI
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
reactant: MODEL1310110006#
reversible: true
modifier: MODEL1310110006#
name: triose-phosphate isomerase
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/5.3.1.1
is described by: ECO:0000134

metaR r2341
reversible: true
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
fast: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

metaM decdicrn c
initial amount: NaN
is: HMDB13325
initial concentration: 1.0
is: SBO:0000247
name: decadienoyl carnitine
constant: false
notes: FORMULA: C17H29NO4 CHARGE: 0
type: Species
has only substance units: false
boundary condition: false

metaR ACP1 FMN
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.2
modifier: MODEL1310110006#
name: acid phosphatase (FMN)
is described by: ECO:0000254
type: Reaction
reactant: MODEL1310110006#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
product: MODEL1310110006#
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_f221ca20_e629_4cb1_875c_351140f04824
name: CA12
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: O43570
has only substance units: false
is encoded by: hsa:771

metaR CGLYt3 2
fast: false
reactant: MODEL1310110006#
is: SBO:0000185
reversible: false
name: Cys-Gly transport in via proton symport
modifier: MODEL1310110006#
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_92e6046b_debf_4f54_8c5b_a63f4c5f435c
constant: false
boundary condition: true
is encoded by: hsa:3945
initial amount: NaN
type: Species
initial concentration: NaN
is: P07195
is: SBO:0000252
has only substance units: false
name: LDHB

http://identifiers.org/biomodels.db/MODEL1310110006#_2fd4f8b7_9243_4d0f_86ea_57cc984adb9d
is: B3KRT1
name: ISYNA1
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:51477
type: Species
has only substance units: false
initial concentration: NaN

metaR GALASE10ly
kinetic law: MODEL1310110006#
name: beta-galactosidase, lysosomal
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110006#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110006#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
fast: false
reversible: false

metaM dtdp n
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: CHEBI:58369
initial concentration: 1.0
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
is: HMDB01274
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_metaM_acgalfuc12gal14acglcgalgluside_hs_g
is: CHEBI:57847
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
initial concentration: 1.0
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0
is: HMDB00304
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false

metaR FAOXC226m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

metaR CYSTA
reactant: MODEL1310110006#
fast: false
name: cysteine transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
modifier: MODEL1310110006#
type: Reaction
is: SBO:0000176
is described by: ECO:0000304
reversible: true
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.6.1.1

http://identifiers.org/biomodels.db/MODEL1310110006#_a0bfeba8_5190_4a47_8683_2a498570b4d3
initial concentration: NaN
boundary condition: true
name: PDE9A
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:5152
is: SBO:0000252
type: Species

metaM spc hs c
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/5311445
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: sphingosylphosphorylcholine
type: Species
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
is: SBO:0000247

metaM f1a l
name: F1alpha
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15936
constant: false
boundary condition: false

metaR r1610
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110006#
fast: false
type: Reaction
reactant: MODEL1310110006#
reversible: true

metaM g1p e
is: CHEBI:58601
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
is: HMDB01586
name: alpha-D-glucose 1-phosphate(2-)
boundary condition: false
initial amount: NaN
constant: false
type: Species

metaR S23T4g
product: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
reactant: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.4
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: beta-galactoside alpha-2,3-sialyltransferase
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_d982b478_ca0b_4dd4_8ca2_3f42faa7068a
is: Q7Z725
is encoded by: hsa:6569
has only substance units: false
name: SLC34A1
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM fuc L l
is: CHEBI:18287
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: L-fucose
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
constant: false
initial concentration: 1.0
is: HMDB00174
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_5d284dce_c916_41b5_a5cf_76b03668ed53
initial amount: NaN
is encoded by: hsa:5305
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P48426
name: PIP4K2A
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_69082f2d_f48a_4e61_acbb_3f4fc2d93e84
name: SUCLG1
is: SBO:0000252
is encoded by: hsa:8802
has only substance units: false
is: P53597
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false

metaR r1252
is described by: ECO:0000000
product: MODEL1310110006#
reversible: false
name: EC:6.2.1.3
fast: false
is: SBO:0000176
kinetic law: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaM dtdp m
is: C00363
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
name: dTDP
boundary condition: false
constant: false
type: Species
is: HMDB01274
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:58369
initial concentration: 1.0

metaR CMPSAS
name: CMP sialic acid synthase
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.7.43
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000304
reactant: MODEL1310110006#
fast: false
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD

metaM 3mb2coa m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: 3-methylbut-2-enoyl-CoA(4-)
constant: false
type: Species
is: CHEBI:57344
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
is: HMDB01493
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_3477c24a_a366_48d0_a526_4308f588c0d4
name: _AU149534_1_c
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AU149534
is: SBO:0000252
initial concentration: NaN
type: Species

metaM chito2pdol L c
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
is: CHEBI:12427
has only substance units: false
is: HMDB01196
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
initial amount: NaN

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_7cc00b24_9fc3_4016_973c_9467716b9536
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7296
is: SBO:0000252
name: TXNRD1
constant: false

metaR CYOOm3
reactant: MODEL1310110006#
reversible: false
type: Reaction
name: cytochrome c oxidase, mitochondrial Complex IV
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
fast: false
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.9.3.1
is described by: ECO:0000134
product: MODEL1310110006#
is: SBO:0000185

metaR SBCOAACOTx
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_ea8c438e_7a5e_4d21_a4d8_dfbe216a936d
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:84649
initial concentration: NaN
name: DGAT2
is: Q96PD7

metaR r1612
is described by: ECO:0000000
reactant: MODEL1310110006#
is: SBO:0000185
type: Reaction
product: MODEL1310110006#
reversible: true
modifier: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110006#
fast: false

metaR r0245
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
modifier: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
product: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_b2ddf623_fb5c_481b_9684_275cfe94f909
boundary condition: true
is encoded by: hsa:6548
name: SLC9A1
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: P19634

metaR PFK26
is version of: http://identifiers.org/ec-code/2.7.1.105
type: Reaction
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000
name: 6-phosphofructo-2-kinase
reactant: MODEL1310110006#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (5210.1) or (5207.1) or (5209.1) or (5208.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.105 Confidence Level: 0 AUTHORS: NOTES:IF

metaR FAOXC61C4m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaM 4nph c
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
has only substance units: false
is: CHEBI:57917
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB01232
name: 4-nitrophenolate
boundary condition: false
is: SBO:0000247
constant: false

metaR GALASE19ly
reversible: false
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110006#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
is described by: ECO:0000269

metaM hs deg22 l
is: HMDB02704
constant: false
boundary condition: false
is: CHEBI:21338
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C37H56NO35S CHARGE: -3
initial amount: NaN

metaR NAt3 1
kinetic law: MODEL1310110006#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
reversible: true
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
name: sodium proton antiporter (H:NA is 1:1)
type: Reaction

metaR CSBPASEly
reactant: MODEL1310110006#
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
kinetic law: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
product: MODEL1310110006#

metaR r1611
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
product: MODEL1310110006#
reversible: true
is: SBO:0000185

metaR r0246
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
product: MODEL1310110006#
is: SBO:0000176
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction

metaR EX c16dc
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_8fb482e0_279d_449f_bc34_7bb5033b2066
has only substance units: false
is: P48736
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:5294
name: PIK3CG
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_10ac426d_a696_4b67_bff1_c20fed680654
name: APRT
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:353
is: P07741
boundary condition: true
type: Species

metaR FAOXC181C181OHm
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C18:1OH)m
type: Reaction

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaR MALTSULtm
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110006#
fast: false
modifier: MODEL1310110006#
name: Malate:thiosulfate antiport, mitochondrial
reactant: MODEL1310110006#

metaR KSII CORE4tly
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
product: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
type: Reaction
name: keratan sulfate II (core 4) transport, extracellular to lysosome

http://identifiers.org/biomodels.db/MODEL1310110006#_42384bc9_1d6f_4bac_87d9_83a65bafc2a7
boundary condition: true
name: ECHS1
is: P30084
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:1892
is: SBO:0000252

metaR C40CPT1
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaM pyr c
initial amount: NaN
has only substance units: false
is: HMDB00243
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1
is: CHEBI:15361
is: http://identifiers.org/pubchem.compound/3324
is: SBO:0000247
constant: false
is: C00022
boundary condition: false
initial concentration: 1.0
name: pyruvate

metaR r0780
reversible: true
product: MODEL1310110006#
modifier: MODEL1310110006#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110006#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
reactant: MODEL1310110006#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110006#_98fb1f3d_2281_4c84_a114_61c0232b380f
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
name: TUSC3
has only substance units: false
is encoded by: hsa:7991
initial concentration: NaN
boundary condition: true

metaR GGH 7THFe
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (7THF), extracellular
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
product: MODEL1310110006#
is: SBO:0000176
fast: false
reactant: MODEL1310110006#

metaM gal1p c
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
type: Species
is: HMDB00645
has only substance units: false
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
is: CHEBI:58336
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false

metaM octdececrn m
is: SBO:0000247
initial amount: NaN
name: octadecenoyl carnitine (hypothetical, position of double bond unknown)
notes: FORMULA: C25H47NO4 CHARGE: 0
constant: false
initial concentration: 1.0
is: HMDB06351
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_2da63fa1_66fb_468b_b712_725a902e0001
is encoded by: hsa:1329
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: COX5B
is: Q53YB7
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_4a49fd80_2c52_482a_aad5_f8e48a42f2b9
has only substance units: false
is: P48735
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:3418
name: IDH2
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_481b719f_582d_414c_a2a6_6c72238581f6
has only substance units: false
constant: false
initial amount: NaN
is: Q9HAS3
type: Species
name: SLC28A3
is encoded by: hsa:64078
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_61390959_e35d_4b07_9afe_32ea89ee665d
type: Species
boundary condition: true
name: GALNT13
is encoded by: hsa:114805
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q8IUC8

metaM 34hpp e
constant: false
type: Species
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00707
initial concentration: 1.0
name: 3-(4-hydroxyphenyl)pyruvate
has only substance units: false
is: CHEBI:36242

metaM m2emgacpail hs r
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
boundary condition: false
notes: FORMULA: C51H94N2O32P2FULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
is: C00080
type: Species
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)
is: SBO:0000247
is: CHEBI:24636

metaM tmndnccoa m
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: timnodonyl coenzyme A
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
is: HMDB06514
initial concentration: 1.0
initial amount: NaN

metaR r0781
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
modifier: MODEL1310110006#
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR DNDPt24m
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110006#
reactant: MODEL1310110006#
name: dTDP transport via dADP antiport
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_4540dadb_c20e_45b3_998a_f918a08cd3df
constant: false
is: SBO:0000252
name: ST3GAL3
boundary condition: true
is encoded by: hsa:6487
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_f67611be_7d85_4503_b666_e88cb5032bf2
name: SUCLG2:SUCLG1
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:8801
initial amount: NaN
has part: Q96I99
is encoded by: hsa:8802
is: SBO:0000297
has only substance units: false
has part: P53597

metaM 3hdcoa m
name: (S)-3-Hydroxydecanoyl-CoA
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C31H50N7O18P3S CHARGE: -4

metaM ksii core2 pre6 g
boundary condition: false
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 6
notes: FORMULA: C61H98N5O46SX CHARGE: -2
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM spc hs e
boundary condition: false
name: sphingosylphosphorylcholine
is: SBO:0000247
constant: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5311445
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_4b48b2ee_dcae_433a_9a79_d353d21ee54b
type: Species
initial amount: NaN
is: Q86SK9
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:79966
name: SCD5
initial concentration: NaN
is: SBO:0000252

metaM pyr e
name: pyruvate
is: HMDB00243
is: CHEBI:15361
has only substance units: false
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_b26fbc0e_70c4_40a0_b5e9_b2aab0a6e9c9
is encoded by: hsa:23657
constant: false
boundary condition: true
name: SLC7A11
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is: Q9UPY5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_df5e2e51_f9b5_4bbe_8984_f2a1baa1de7c
is: Q9NUD9
is encoded by: hsa:55650
is: SBO:0000252
name: PIGV
constant: false
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_a3e73e6e_5b7c_48b0_984c_0a13b7e9c85f
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P00813
initial concentration: NaN
name: ADA
type: Species
is encoded by: hsa:100

http://identifiers.org/biomodels.db/MODEL1310110006#_873cda34_9be4_490a_a984_501592274086
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P11908
initial concentration: NaN
is encoded by: hsa:5634
type: Species
boundary condition: true
constant: false
name: PRPS2

http://identifiers.org/biomodels.db/MODEL1310110006#_07ca7ec9_ffaa_46db_b542_245098398454
is: O43306
type: Species
boundary condition: true
is encoded by: hsa:112
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
name: ADCY6
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_5564c7ee_93fd_4068_a20f_edcf6f1c05b5
initial concentration: NaN
name: FLAD1
constant: false
initial amount: NaN
is encoded by: hsa:80308
boundary condition: true
is: Q8NFF5
type: Species
has only substance units: false
is: SBO:0000252

metaR PItg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: false
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000185
type: Reaction
fast: false
name: phosphate transport, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110006#_20b19365_b3f0_440a_9550_d8ff120f349c
name: TXNRD1
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:7296
boundary condition: true

metaM 34hpp c
boundary condition: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
has only substance units: false
is: SBO:0000247
is: CHEBI:36242
type: Species
initial concentration: 1.0
name: 3-(4-hydroxyphenyl)pyruvate
constant: false
initial amount: NaN
is: HMDB00707

metaM ksi deg6 l
is: CHEBI:12936
name: keratan sulfate I, degradation product 6
initial amount: NaN
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
boundary condition: false
is: HMDB00143
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false

metaR r0892
modifier: MODEL1310110006#
is: SBO:0000185
product: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.1.2.27

metaM prostgh2 r
constant: false
is: HMDB01381
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: prostaglandin H2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial amount: NaN
type: Species
is: CHEBI:57405
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_e1a705c4_0397_4fdd_9801_4e9cb3afd95f
initial concentration: NaN
name: CA1
is encoded by: hsa:759
is: SBO:0000252
is: P00915
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

metaR Coqe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
name: Transport of q10
fast: false
is: SBO:0000185
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR AG13T3g
modifier: MODEL1310110006#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
reversible: false
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
is described by: ECO:0000000

metaR r0242
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/6.2.1.1
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
modifier: MODEL1310110006#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
is described by: ECO:0000000
type: Reaction

metaR GDPFUCtg
name: GDPFuc Golgi transport via CMP antiport
reversible: true
modifier: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
kinetic law: MODEL1310110006#
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110006#

metaM lnlncgcoa c
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: HMDB06368
type: Species
constant: false
name: gamma-linolenoyl-CoA(4-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:57363
is: SBO:0000247

metaM udpacgal g
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: HMDB00304
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
name: UDP-N-acetyl-D-galactosamine(2-)
is: CHEBI:57847

metaR DOLMANP Lter
fast: false
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
reversible: false
name: dolichol-phosphate mannose flippase (liver)
is: SBO:0000185
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction

metaR r1090
reactant: MODEL1310110006#
is: SBO:0000185
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
is described by: ECO:0000000
product: MODEL1310110006#
fast: false
type: Reaction
kinetic law: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR PRPNCOAHYDm
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.18
fast: false
is: SBO:0000176
reactant: MODEL1310110006#
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110006#
name: Propenoyl-CoA hydrolase (m)
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000134
kinetic law: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay

metaR FAOXC12C10m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)m
type: Reaction

metaR RE2079R
name: RE2079
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
product: MODEL1310110006#
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110006#
reversible: true
kinetic law: MODEL1310110006#
is described by: ECO:0000000

metaR r0472
kinetic law: MODEL1310110006#
fast: false
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaR CLPNDt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is described by: ECO:0000000
product: MODEL1310110006#
name: fatty acid transport via diffusion
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110006#
fast: false
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_857f48da_6f7e_44af_a5bb_2f7cd9a3feb4
name: SLC17A4
is encoded by: hsa:10050
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
is: Q9Y2C5

http://identifiers.org/biomodels.db/MODEL1310110006#_369ce131_e69b_4139_83c2_8695941595dd
is: Q92819
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: HAS2
boundary condition: true
type: Species
is encoded by: hsa:3037
constant: false
is: SBO:0000252

metaM gluside hs c
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:18368
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190

metaR r1109
reactant: MODEL1310110006#
reversible: true
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
fast: false
kinetic law: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110006#

metaR DDPGAm
product: MODEL1310110006#
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000176
reversible: true

metaM ksi deg23 l
type: Species
name: keratan sulfate I, degradation product 23
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:12936
constant: false
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
is: HMDB00143

metaR r1862
modifier: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction
reversible: false
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110006#
name: Y+LAT2 Utilized transport
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR HS2ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/3.10.1.1
kinetic law: MODEL1310110006#
product: MODEL1310110006#
fast: false
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110006#
type: Reaction
name: heparan-N-sulfatase, lysosomal

metaM HC02179 e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: CHEBI:34306
name: 20-hydroxy-arachidonate

metaR XOLDIOLONEt
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
product: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
type: Reaction
name: lipid, flip-flop intracellular transport

metaR GLAl
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
name: galactosidase, alpha
product: MODEL1310110006#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.22
fast: false
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (2717.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.22 Confidence Level: 4 AUTHORS: PMID:11775551,PMID:11828341,PMID:15003450,PMID:2836863 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110006#_daaf88a2_c5eb_4f45_badd_f5be4b2c759b
type: Species
constant: false
name: PDE9A
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5152
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_9ca4a23b_9794_47d7_bdc1_0554a217dfe9
name: UGP2
boundary condition: true
initial concentration: NaN
is: Q16851
is encoded by: hsa:7360
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_38897419_94ed_41d1_974c_7699ddeac7e9
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:AD000092
has only substance units: false
type: Species
initial concentration: NaN
name: _AD000092_1_c
constant: false

metaR FAOXC226C205m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_1963d2ab_819b_4fb0_a503_25ad6db3c323
is: Q9H845
type: Species
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:28976
name: ACAD9
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR DCMPDA
name: dCMP deaminase
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.12
is: SBO:0000176
reactant: MODEL1310110006#
reversible: true
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110006#_fb7b4704_b0fb_4b16_9d1d_da07015246ad
constant: false
is encoded by: hsa:1103
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: D3DX95
name: CHAT

metaR r1649
reactant: MODEL1310110006#
is: SBO:0000185
product: MODEL1310110006#
type: Reaction
reversible: true
modifier: MODEL1310110006#
is described by: ECO:0000000
kinetic law: MODEL1310110006#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM h2o g
type: Species
is: HMDB02111
is: CHEBI:15377
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
name: water
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaM pentcoa m
is: HMDB13037
constant: false
is: SBO:0000247
is: C00888
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
name: pentanoylcoa
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_1d9231b7_33ab_457b_b2e0_968b85f96294
constant: false
initial concentration: NaN
is encoded by: hsa:5286
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
name: PIK3C2A
is: O00443

metaR r0474
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110006#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110006#
fast: false
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_436d62ea_c00d_4869_984f_f74df619b72a
type: Species
is encoded by: hsa:8884
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
name: SLC5A6
is: Q9HD19
initial concentration: NaN

metaM idour c
is: CHEBI:21338
name: L-iduronate
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB02704
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: SBO:0000247
constant: false

metaM succ c
is: C00042
initial amount: NaN
constant: false
type: Species
is: CHEBI:30031
is: HMDB00254
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial concentration: 1.0
name: Succinate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_2b06dbc6_f698_4ab4_9f21_67a208dac879
constant: false
has only substance units: false
is encoded by: hsa:5313
is: P30613
boundary condition: true
name: PKLR
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_457fe792_5044_4896_ba3f_0f8b0ccb1020
is: P21953
name: BCKDHB
has only substance units: false
is encoded by: hsa:594
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110006#_cc4bf319_e226_4233_9c7d_ea70e5c51a50
initial amount: NaN
has only substance units: false
name: PDE6H
constant: false
initial concentration: NaN
is encoded by: hsa:5149
type: Species
is: Q13956
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_2a1ae1c1_1f86_460d_a90f_6b24b244ec57
constant: false
type: Species
name: SLC6A2
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q96KH8
initial concentration: NaN
is encoded by: hsa:6530
boundary condition: true

metaR SUCCt2m
name: succinate transport, mitochondrial
is: SBO:0000185
modifier: MODEL1310110006#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110006#
fast: false
product: MODEL1310110006#
reversible: true

metaM citr L e
type: Species
is: HMDB00904
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
constant: false
has only substance units: false
initial concentration: 1.0
name: citr_L[e]
is: SBO:0000247
is: CHEBI:16349

http://identifiers.org/biomodels.db/MODEL1310110006#_01dda850_5ab3_4cc5_bbfa_11c249c78902
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: O00746
type: Species
is encoded by: hsa:4833
is: SBO:0000252
name: NME4
constant: false

http://identifiers.org/biomodels.db/MODEL1310110006#_24faafcf_ff2e_4e9d_ac0c_cfe7b76d8581
constant: false
initial amount: NaN
is encoded by: hsa:9963
has only substance units: false
is: SBO:0000252
name: SLC23A1
type: Species
is: Q9UHI7
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110006#_12fc8c8a_70d4_4ea1_a40c_63f20e44bfd8
constant: false
has only substance units: false
is encoded by: hsa:291
initial concentration: NaN
type: Species
boundary condition: true
name: SLC25A4
initial amount: NaN
is: P12235
is: SBO:0000252

metaM CE4791 x
type: Species
is: SBO:0000247
is: CHEBI:57923
initial amount: NaN
notes: FORMULA: C41H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C41H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(49)24-32(51)70-23-22-43-31(50)20-21-44-39(54)36(53)41(2,3)26-63-69(60,61)66-68(58,59)62-25-30-35(65-67(55,56)57)34(52)40(64-30)48-28-47-33-37(42)45-27-46-38(33)48/h8-9,11-12,14-15,27-30,34-36,40,49,52-53H,4-7,10,13,16-26H2,1-3H3,(H,43,50)(H,44,54)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/b9-8-,12-11-,15-14-/t29-,30-,34+,35+,36u,40-/m0/s1 EHMN_ABBREVIATION: CE4791
has only substance units: false
name: 3(S)-hydroxy-dihomo-gama-linolenoyl-CoA
constant: false
boundary condition: false
initial concentration: 1.0

metaM udpacgal c
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
name: UDP-N-acetyl-D-galactosamine(2-)
is: SBO:0000247
is: CHEBI:57847
has only substance units: false
is: HMDB00304

http://identifiers.org/biomodels.db/MODEL1310110006#_3e96beef_fbfc_4b60_804c_7e1c6155a27c
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:8803
initial concentration: NaN
constant: false
has part: E5KS60
boundary condition: true
name: SUCLG1:SUCLA2

metaR AG13T12g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
modifier: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000

metaM Lcystin e
is: HMDB00192
boundary condition: false
constant: false
initial amount: NaN
name: L-cystine
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:16283
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
initial concentration: 1.0

metaM C02528 r
has only substance units: false
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
name: chenodeoxycholate
is: SBO:0000247
is: CHEBI:36234
initial amount: NaN
is: HMDB00518
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528

http://identifiers.org/biomodels.db/MODEL1310110006#_330b2221_34b2_4a7d_8d67_eee6dcddc703
is encoded by: hsa:7357
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q16739
constant: false
name: UGCG
initial concentration: NaN
type: Species
initial amount: NaN

metaM prostgh2 e
initial amount: NaN
is: CHEBI:57405
name: prostaglandin H2(1-)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB01381
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
type: Species
boundary condition: false

metaR C5DCe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

metaM glu L m
is: HMDB00148
has only substance units: false
boundary condition: false
is: CHEBI:29985
is: SBO:0000247
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
name: L-glutamate(1-)
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false

metaR r2056
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110006#
fast: false
is: SBO:0000185
reactant: MODEL1310110006#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110006#

metaR 5MTHFt
modifier: MODEL1310110006#
type: Reaction
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is: SBO:0000185
product: MODEL1310110006#
reversible: true
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110006#_fd7be7a5_f9ad_467b_824a_96ce7d67bda7
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
name: _AI697028_1_m
is encoded by: hsa:AI697028
has only substance units: false
constant: false

metaM apoC Lys c
is: SBO:0000247
notes: FORMULA: C6H13N2OX CHARGE: 0
constant: false
is: HMDB00182
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
name: Apocarboxylase (Lys residue)
is: CHEBI:32551
has only substance units: false

metaM ddcacoa m
is: SBO:0000247
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C01832
constant: false
is: CHEBI:57375
has only substance units: false
is: HMDB03571
type: Species

metaR URAt
reactant: MODEL1310110006#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
modifier: MODEL1310110006#
name: uracil transport via facilated diffusion
reversible: true
is: SBO:0000185
product: MODEL1310110006#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_d7eaf497_27ef_44f2_bce9_b7a697eb694e
name: _286297_1_c
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:286297
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM duri n
is: CHEBI:16450
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
is: HMDB00012
has only substance units: false
name: 2'-deoxyuridine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526

metaM h2o n
constant: false
name: water
type: Species
is: CHEBI:15377
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB02111

http://identifiers.org/biomodels.db/MODEL1310110006#_f744cfb2_e9ea_4c76_9ee1_59f1b0186b42
boundary condition: true
is encoded by: hsa:54539
is: Q9NX14
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: NDUFB11

metaM hs deg14 l
has only substance units: false
is: CHEBI:16126
name: heparan sulfate, degradation product 14
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaR O2Stn
fast: false
product: MODEL1310110006#
reversible: true
is: SBO:0000185
name: superoxide anion transport via diffusion (nucleus)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
is described by: ECO:0000000

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaM thbpt4acam n
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial concentration: 1.0
is: CHEBI:15374
constant: false
type: Species
boundary condition: false
is: HMDB02281
name: 4a-hydroxytetrahydrobiopterin

metaM gluside hs g
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:18368
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
constant: false
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0

metaM m5mpdol L r
type: Species
boundary condition: false
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247
is: CHEBI:37634
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C1600H2628N20O470P20 CHARGE: -20

http://identifiers.org/biomodels.db/MODEL1310110006#_f2cc73db_04b8_48e7_9ea3_97c63bb79d2d
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: O00154
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:11332
name: ACOT7

metaR G14T7g
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
modifier: MODEL1310110006#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaM gacpail hs r
is: HMDB01401
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:61548
type: Species
is: C00092
name: glucosaminyl-acylphosphatidylinositol
initial concentration: 1.0
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_dcd3aae8_cab1_4173_8633_c47d614c9678
is encoded by: hsa:10087
name: COL4A3BP
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q9Y5P4
type: Species
constant: false

metaM tsul m
is: CHEBI:16094
is: HMDB00257
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: SBO:0000247
constant: false
initial concentration: 1.0
name: thiosulfate(2-)
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_1e91ddc7_42d7_4a28_a91e_0e993260809a
boundary condition: true
is encoded by: hsa:56301
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:6520
name: SLC7A10:SLC3A2
has part: Q9NS82
initial concentration: NaN
is: SBO:0000297
has part: P08195

metaM citr L c
is: HMDB00904
name: L-citrulline
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16349
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
has only substance units: false
type: Species

metaR r0475
fast: false
type: Reaction
kinetic law: MODEL1310110006#
reversible: true
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is described by: ECO:0000000
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is: SBO:0000176
product: MODEL1310110006#

metaR r2099
modifier: MODEL1310110006#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaM h2o m
is: CHEBI:15377
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
name: H2O
is: C00001
is: HMDB02111
is: SBO:0000247
has only substance units: false

metaR EICOSTETt
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#

metaM prostgh2 c
name: prostaglandin H2(1-)
is: CHEBI:57405
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB01381
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
constant: false
type: Species
boundary condition: false

metaR O2Stm
kinetic law: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000
name: superoxide anion transport via diffusion (mitochondria)
product: MODEL1310110006#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:

metaM pmtcrn c
constant: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
is: CHEBI:17490
is: HMDB00222
is: SBO:0000247
boundary condition: false
name: L-palmitoylcarnitine
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM Lcystin c
is: CHEBI:16283
boundary condition: false
is: HMDB00192
constant: false
initial amount: NaN
name: L-cystine
has only substance units: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110006#_b8ac1768_698f_4d80_a60c_f204d2585933
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q16647
boundary condition: true
constant: false
name: PTGIS
type: Species
is encoded by: hsa:5740

metaM dtdp e
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
is: HMDB01274
type: Species
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial concentration: 1.0

metaR SERDGLYexR
kinetic law: MODEL1310110006#
is described by: ECO:0000304
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110006#
name: D-Serine/Glycine reversible exchange
modifier: MODEL1310110006#
type: Reaction
reactant: MODEL1310110006#
fast: false

metaM h2o l
has only substance units: false
name: water
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB02111
type: Species
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
initial amount: NaN
constant: false

metaR r1863
reactant: MODEL1310110006#
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
product: MODEL1310110006#
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaR PROSTGD2t
reversible: true
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110006#
fast: false
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269

metaR FAOXC161802m
kinetic law: MODEL1310110006#
is: SBO:0000176
product: MODEL1310110006#
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
reactant: MODEL1310110006#
fast: false
is described by: ECO:0000269

metaR RE2666C
is: SBO:0000176
product: MODEL1310110006#
fast: false
is described by: ECO:0000000
name: RE2666
kinetic law: MODEL1310110006#
reversible: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_961223fa_8c6e_40ee_bc77_c69b050da5da
name: DPAGT1
constant: false
is encoded by: hsa:1798
is: Q9H3H5
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true

metaR S6TASE3ly
modifier: MODEL1310110006#
type: Reaction
fast: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_c5236b0b_8e1c_472c_ba59_66b28d3e9fdd
initial concentration: NaN
type: Species
name: _AV717590_1_m
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:AV717590

metaR DCYTDn
name: deoxycytidine deaminase, nuclear
is version of: http://identifiers.org/ec-code/3.5.4.5
kinetic law: MODEL1310110006#
reversible: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
modifier: MODEL1310110006#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000254
product: MODEL1310110006#

metaR FAOXC184m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaR 5ADTSTSTERONEte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
is: SBO:0000185
reactant: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
product: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
name: 5 alpha dihydrotesterone transport

http://identifiers.org/biomodels.db/MODEL1310110006#_d5bad7c4_a238_48a7_b822_b03dc853042d
name: PDE6A:PDE6H:PDE6B
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
has part: P16499
is encoded by: hsa:5149
has part: Q13956
is: SBO:0000297
is encoded by: hsa:5145
is encoded by: hsa:5158
type: Species
has part: B7Z9T9

metaM fmn e
is: SBO:0000247
type: Species
has only substance units: false
constant: false
is: HMDB01520
boundary condition: false
is: C00061
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C17H19N4O9P CHARGE: -2
is: CHEBI:58210
name: FMN

http://identifiers.org/biomodels.db/MODEL1310110006#_edae61c1_b4d3_4924_b1a9_aff4848bb5d6
initial concentration: NaN
name: ATG9B
boundary condition: true
has only substance units: false
is encoded by: hsa:285973
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: Q674R7

metaM hexe3coa m
boundary condition: false
has only substance units: false
is: SBO:0000247
name: 3-hexenoylcoa
is: HMDB06522
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4

metaM btcoa c
is: HMDB01088
is: CHEBI:57371
type: Species
constant: false
initial concentration: 1.0
is: C00136
has only substance units: false
name: Butanoyl-CoA
initial amount: NaN
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: SBO:0000247
boundary condition: false

metaM pe hs m
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
name: phosphatidylethanolamine
initial concentration: 1.0
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350

metaR FAOXC61x
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

metaR 5ADTSTSTERONEtr
is: SBO:0000185
fast: false
kinetic law: MODEL1310110006#
type: Reaction
product: MODEL1310110006#
reversible: true
reactant: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: 5 alpha dihydrotesterone intracellular transport

metaM HC02023 r
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:46898
name: Cholesterol-ester-ol
constant: false

metaR LEUKTRD4t
name: leukotriene D4 transport
is described by: ECO:0000269
reactant: MODEL1310110006#
product: MODEL1310110006#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
kinetic law: MODEL1310110006#
type: Reaction
reversible: true

metaM dtdp c
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
is: HMDB01274
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:58369
initial amount: NaN
is: C00363
name: dTDP

metaR LEUGLYHYc
fast: false
product: MODEL1310110006#
is described by: ECO:0000134
name: hydrolysis of leucylglycine
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
reversible: true
type: Reaction
kinetic law: MODEL1310110006#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_c4ef4246_02c4_4300_a967_371910b9fc57
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: ALDH2
is: P05091
initial concentration: NaN
is encoded by: hsa:217
constant: false

metaR DOLGLCP Lter
product: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110006#
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110006#_5afe09aa_e12f_41b7_a123_99a1745fdf26
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:8560
type: Species
is: SBO:0000252
is: O15121
initial concentration: NaN
has only substance units: false
name: DEGS1

metaR RE3626M
type: Reaction
modifier: MODEL1310110006#
is: SBO:0000176
reversible: false
name: RE3626
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110006#

metaM ksii core2 pre5 g
is: CHEBI:58053
initial amount: NaN
boundary condition: false
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: SBO:0000247
is: C00130
is: HMDB00175
has only substance units: false
constant: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 5
type: Species

metaR DOPASFt
fast: false
reactant: MODEL1310110006#
reversible: false
kinetic law: MODEL1310110006#
name: Dopamine 3-0-sulfate transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
product: MODEL1310110006#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_78a88fb7_d332_4976_becf_e66184e2f763
type: Species
has only substance units: false
is: Q15392
name: DHCR24
is encoded by: hsa:1718
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaM 5mthf e
is: CHEBI:3729
name: 5-Methyltetrahydrofolate
type: Species
is: C00440
is: HMDB01396
boundary condition: false
constant: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM bildglcur c
constant: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial amount: NaN
is: HMDB03325
is: CHEBI:58471
initial concentration: 1.0
name: bis(beta-glucosyluronate)bilirubin
has only substance units: false

metaR CYTK3n
fast: false
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reactant: MODEL1310110006#
modifier: MODEL1310110006#
reversible: true
name: cytidylate kinase (dCMP,CTP),nuclear
is described by: ECO:0000269
kinetic law: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110006#_2311bdef_6cd9_4114_98d3_88ef04813299
constant: false
is encoded by: hsa:10317
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: Q9Y2C3
initial amount: NaN
name: B3GALT5

metaR LNELDCCPT1
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110006#
reversible: false
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
is: SBO:0000176
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110006#_f3c1d7f3_f28d_4202_b3d1_e0d1d4b13a85
has only substance units: false
is encoded by: hsa:1375
type: Species
is: E9PCP2
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: CPT1B
is: SBO:0000252
constant: false

metaM atp c
boundary condition: false
is: HMDB00538
is: C00002
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:30616
name: ATP(4-)
constant: false
is: SBO:0000247

metaR r0556
reversible: true
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
type: Reaction
is: SBO:0000176
product: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.14.19.1
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
fast: false
reactant: MODEL1310110006#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaR RE2999M
is version of: http://identifiers.org/ec-code/5.3.3.8
name: RE2999
kinetic law: MODEL1310110006#
is described by: ECO:0000000
reversible: true
product: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
modifier: MODEL1310110006#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM HC01412 m
constant: false
initial amount: NaN
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:61405
name: trans-tetradec-2-enoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110006#_513120d9_700d_43f6_9834_ad1ec382aea6
is encoded by: hsa:84105
initial concentration: NaN
boundary condition: true
is: Q9H0N5
name: PCBD2
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR ABTti
is described by: ECO:0000000
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reversible: false
is: SBO:0000185
reactant: MODEL1310110006#
fast: false
product: MODEL1310110006#
type: Reaction
name: L-arabinitol transport via passive diffusion

metaR PRASCS
modifier: MODEL1310110006#
reversible: true
product: MODEL1310110006#
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.2.6
reactant: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110006#
is: SBO:0000176

metaR r0321
is: SBO:0000176
reversible: false
modifier: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
is version of: http://identifiers.org/ec-code/6.3.5.2
fast: false
type: Reaction

metaM 5mthf c
boundary condition: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
has only substance units: false
is: C00440
initial concentration: 1.0
name: 5-Methyltetrahydrofolate
constant: false
is: SBO:0000247
type: Species
is: CHEBI:3729
is: HMDB01396
initial amount: NaN

metaR LNELDCCPT2
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
name: carnitine transferase
modifier: MODEL1310110006#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110006#_1e02f02e_da80_42a6_8c86_b2d8ccfafd67
has only substance units: false
is encoded by: hsa:39
boundary condition: true
is: Q9BWD1
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
name: ACAT2
initial amount: NaN

metaR r2347
type: Reaction
fast: false
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110006#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110006#
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110006#_fa98777e_9723_458d_a356_b5d889011332
is: Q9UJA2
type: Species
name: CRLS1
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:54675

metaR SPMTDe
fast: false
is: SBO:0000185
product: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
reactant: MODEL1310110006#
name: SPMTDe

metaR r0559
reactant: MODEL1310110006#
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110006#
type: Reaction
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
fast: false

metaM thbpt4acam c
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB02281
name: 4a-hydroxytetrahydrobiopterin
is: CHEBI:15374
constant: false
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial amount: NaN

metaM lnlncgcoa m
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB06368
is: CHEBI:57363
type: Species
name: gamma-linolenoyl-CoA(4-)
initial amount: NaN
constant: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
boundary condition: false

metaR RE2954C
is: SBO:0000176
modifier: MODEL1310110006#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
name: RE2954
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110006#
type: Reaction
kinetic law: MODEL1310110006#
fast: false

metaM hs deg8 l
is: CHEBI:16126
has only substance units: false
initial amount: NaN
name: heparan sulfate, degradation product 8
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
type: Species
initial concentration: 1.0

metaM apoC Lys m
constant: false
initial amount: NaN
is: HMDB00182
type: Species
has only substance units: false
is: CHEBI:32551
name: Apocarboxylase (Lys residue)
notes: FORMULA: C6H13N2OX CHARGE: 0
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR r0558
type: Reaction
is: SBO:0000176
reversible: true
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
kinetic law: MODEL1310110006#
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110006#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reactant: MODEL1310110006#
is described by: ECO:0000000
fast: false

metaR r2346
fast: false
kinetic law: MODEL1310110006#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
product: MODEL1310110006#
reversible: true

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_72f4612f_e0dc_4e6d_98e4_7b1207fb6787
initial amount: NaN
name: LDHAL6B
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:92483
constant: false
is: Q9BYZ2

http://identifiers.org/biomodels.db/MODEL1310110006#_7611c252_0069_4b98_8d44_fe7f76496782
constant: false
is encoded by: hsa:1650
has part: P04844
has part: P04843
is encoded by: hsa:6184
initial amount: NaN
is encoded by: hsa:6185
name: DAD1:DDOST:RPN1:RPN2
has part: Q53G02
type: Species
boundary condition: true
is encoded by: hsa:1603
has part: P39656
is: SBO:0000297
initial concentration: NaN
has only substance units: false

metaR FAOXC161C141m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

metaM pail35p hs c
initial concentration: 1.0
constant: false
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
boundary condition: false
is: CHEBI:57923
has only substance units: false
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial amount: NaN
is: SBO:0000247

metaM gacpail hs c
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
is: SBO:0000247
name: glucosaminyl-acylphosphatidylinositol
is: CHEBI:61548
initial amount: NaN
constant: false
type: Species
is: C00092
boundary condition: false
is: HMDB01401
initial concentration: 1.0

metaM tsul c
type: Species
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: thiosulfate(2-)
has only substance units: false
initial amount: NaN
is: CHEBI:16094
is: HMDB00257

metaR r0553
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110006#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110006#
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reversible: true
kinetic law: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_50aea370_6f4e_422c_ba02_2cb2ccb7fecc
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9962
name: SLC23A2
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_ef4781d8_642a_4269_8f5e_057d6eae4949
initial amount: NaN
initial concentration: NaN
is: Q308M7
name: ENPP3
is: SBO:0000252
constant: false
is encoded by: hsa:5169
type: Species
boundary condition: true
has only substance units: false

metaR FAOXC18C18OHm
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

metaR GASNASEly
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110006#
is: SBO:0000176
product: MODEL1310110006#
fast: false
modifier: MODEL1310110006#
type: Reaction
is described by: ECO:0000000
name: glycosylasparaginase, lysosomal
is version of: http://identifiers.org/ec-code/3.5.1.26
reversible: false
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_35d27be1_61f8_4673_9132_bd538b82a20b
is: SBO:0000252
constant: false
has only substance units: false
is: O95907
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:23539
initial amount: NaN
name: SLC16A8

metaM dgsn c
name: Deoxyguanosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
initial amount: NaN
constant: false
has only substance units: false
is: HMDB00085
initial concentration: 1.0
is: C00330
is: CHEBI:17172
boundary condition: false
type: Species
is: SBO:0000247

metaM galside hs l
initial amount: NaN
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
boundary condition: false
has only substance units: false
is: CHEBI:12947
is: SBO:0000247
type: Species
name: D-galactosyl-N-acylsphingosine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_c381c473_3e6f_4196_9840_869878a00b1f
initial concentration: NaN
is: P20020
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:490
type: Species
name: ATP2B1
has only substance units: false
boundary condition: true

metaM duri e
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00012
name: Deoxyuridine
type: Species
initial amount: NaN
constant: false
is: CHEBI:16450
has only substance units: false
is: C00526

metaM hexe3coa x
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
name: 3-hexenoylcoa
boundary condition: false
has only substance units: false
is: HMDB06522
initial amount: NaN
constant: false
type: Species

metaM h2o e
is: SBO:0000247
is: CHEBI:15377
boundary condition: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
constant: false
is: HMDB02111
initial amount: NaN
has only substance units: false
name: H2O
is: C00001

metaR r0779
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110006#
is described by: ECO:0000000
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
product: MODEL1310110006#
modifier: MODEL1310110006#
reactant: MODEL1310110006#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_4e122d2b_7255_490c_904d_f334a4917db2
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:27068
name: PPA2
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR r0552
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
product: MODEL1310110006#
modifier: MODEL1310110006#
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110006#
fast: false
reactant: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.3.5.1
is described by: ECO:0000000

metaR CHAT
type: Reaction
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110006#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.6
product: MODEL1310110006#
is: SBO:0000176
name: Choline O-acetyltransferase
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#

metaM leuktrF4 c
is: HMDB06465
name: leukotriene F4
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial concentration: 1.0
type: Species
is: CHEBI:27491
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110006#_88b982be_3c38_4183_9eb3_d95974bdc500
is encoded by: hsa:26290
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: GALNT8
constant: false
is: Q9NY28
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_db569976_4670_4456_8e92_2d4975a0d5ce
name: SLC5A2
constant: false
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: P31639
is: SBO:0000252
is encoded by: hsa:6524

metaR AKGMALtm
kinetic law: MODEL1310110006#
product: MODEL1310110006#
is described by: ECO:0000269
modifier: MODEL1310110006#
reactant: MODEL1310110006#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
name: alpha-ketoglutarate/malate transporter
reversible: true

metaM tsul e
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
name: thiosulfate(2-)
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
is: HMDB00257
is: CHEBI:16094

http://identifiers.org/biomodels.db/MODEL1310110006#_0772504d_d5cf_4167_9754_512cf20731de
initial concentration: NaN
type: Species
name: VNN3:VNN2:VNN1
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:55350
is: SBO:0000297

metaM pe hs c
constant: false
is: SBO:0000247
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
is: CHEBI:16038
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110006#_fb4cf247_db01_4d7c_8bbc_bf089d1f3b96
is: Q9NRF8
type: Species
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:56474
name: CTPS2
initial amount: NaN
has only substance units: false

metaR r1106
kinetic law: MODEL1310110006#
fast: false
reversible: true
type: Reaction
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000000
name: Postulated transport reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110006#_291bae56_3df1_4596_b448_6c294f01f68d
name: ABCB4
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5244
is: A4D1D5
type: Species
initial concentration: NaN
constant: false

metaM h2o c
is: C00001
notes: FORMULA: H2O CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: CHEBI:3303
is: SBO:0000247
type: Species
has only substance units: false
constant: false
name: H2O
is: HMDB02111
initial amount: NaN

metaM ddcacoa x
constant: false
is: C01832
is: SBO:0000247
is: CHEBI:57375
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
type: Species
initial concentration: 1.0
boundary condition: false
name: Dodecanoyl-CoA (n-C12:0CoA)
is: HMDB03571
has only substance units: false
initial amount: NaN

metaR S6T2g
type: Reaction
kinetic law: MODEL1310110006#
product: MODEL1310110006#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110006#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110006#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110006#_5869aa62_086c_4c95_be8d_929664037d7e
type: Species
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:AI653169
initial amount: NaN
name: _AI653169_1_c
is: SBO:0000252

metaM dgsn e
initial amount: NaN
name: Deoxyguanosine
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: HMDB00085
has only substance units: false
is: CHEBI:17172
initial concentration: 1.0
is: C00330
type: Species
is: SBO:0000247
boundary condition: false

metaR DECCRNe
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydecanoyl carnitine into extra cellular space
type: Reaction

metaR FAOXC16C14m
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16-->C14)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110006#_9bb16095_4c28_41c2_a669_5253503aaa4d
boundary condition: true
name: PRDX2
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:7001
initial concentration: NaN
initial amount: NaN
constant: false

metaM leuktrF4 e
boundary condition: false
name: leukotriene F4
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:27491
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: HMDB06465

metaR AMPtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
is: SBO:0000185
reactant: MODEL1310110006#
name: AMP transporter, peroxisome
type: Reaction
product: MODEL1310110006#
kinetic law: MODEL1310110006#
fast: false
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110006#_222dfb86_6862_4c70_bedf_c5851d192195
is encoded by: hsa:3081
has only substance units: false
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: HGD
initial amount: NaN
is: Q93099

metaM HC02179 c
has only substance units: false
boundary condition: false
initial amount: NaN
name: 20-hydroxy-arachidonate
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: SBO:0000247
is: CHEBI:34306
initial concentration: 1.0
type: Species
constant: false

metaR CSAPASEly
kinetic law: MODEL1310110006#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
product: MODEL1310110006#
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
type: Reaction
fast: false
reactant: MODEL1310110006#

metaM bildglcur e
initial concentration: 1.0
name: bis(beta-glucosyluronate)bilirubin
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:58471
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: HMDB03325

metaM pe hs e
is: SBO:0000247
name: phosphatidylethanolamine
type: Species
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaM ptdcacrn m
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
has only substance units: false
name: pendtadenoyl carnitine
type: Species
constant: false
initial amount: NaN
is: CHEBI:18303
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110006#_cf9a8896_5d47_4caa_af65_d7d7fe4d099c
is encoded by: hsa:U37519
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
name: _U37519_1_m
boundary condition: true

metaR HYXNt
is: SBO:0000185
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
name: Hypoxanthine transport
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
product: MODEL1310110006#
reversible: true
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110006#
fast: false

metaM udpacgal l
is: SBO:0000247
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
boundary condition: false
name: UDP-N-acetyl-D-galactosamine(2-)
type: Species
constant: false
initial amount: NaN
is: HMDB00304
is: CHEBI:57847
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110006#_eae32dfb_a1d7_422a_8b9d_3a3afdbe3d43
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: _H17063_1_c
is encoded by: hsa:H17063
type: Species
boundary condition: true
initial amount: NaN

metaR EX 3mop LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxopentanoate
type: Reaction

metaM asn L c
constant: false
is: CHEBI:17196
name: L-asparagine
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
type: Species
boundary condition: false
is: HMDB00168

http://identifiers.org/biomodels.db/MODEL1310110006#_0d747393_4f79_4719_8511_538030b43663
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:BE042354
name: _BE042354_1_m
initial concentration: NaN
constant: false
initial amount: NaN
type: Species

metaM c8dc x
constant: false
is: HMDB00893
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C15H26NO6 CHARGE: -1
has only substance units: false
type: Species
name: suberyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110006#_a84ebe5a_6f80_4da8_9879_502654eb493f
is encoded by: hsa:622
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
name: BDH1

metaR FUT18g
is version of: http://identifiers.org/ec-code/2.4.1.69
is: SBO:0000176
product: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
reactant: MODEL1310110006#
fast: false
kinetic law: MODEL1310110006#
name: Galactoside 2-alpha-L-fucosyltransferase 1
modifier: MODEL1310110006#
reversible: false
is described by: ECO:0000269

metaM lnlncgcoa r
name: gamma-linolenoyl-CoA(4-)
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: CHEBI:57363
initial amount: NaN
is: HMDB06368
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
constant: false

metaM ksii core4 e
initial concentration: 1.0
name: keratan sulfate II (core 4-linked)
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: HMDB00211
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:17268
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110006#_669e3bab_be8d_4ac8_87c3_a3fd05207d2b
has only substance units: false
initial amount: NaN
is encoded by: hsa:8801
constant: false
boundary condition: true
is: SBO:0000252
is: Q96I99
initial concentration: NaN
name: SUCLG2
type: Species

metaR r2352
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110006#
is described by: ECO:0000000
reactant: MODEL1310110006#

metaR r0774
product: MODEL1310110006#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: true
modifier: MODEL1310110006#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37

metaR UDPACGALtl
reactant: MODEL1310110006#
name: udpacgal intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
fast: false
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR ACHEe
type: Reaction
fast: false
is described by: ECO:0000269
product: MODEL1310110006#
name: Acetylcholinesterase
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#
reversible: false
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.1.7
is: SBO:0000176
reactant: MODEL1310110006#

http://identifiers.org/biomodels.db/MODEL1310110006#_f8370879_8627_4f77_b795_bc6e7b9366e4
boundary condition: true
is: SBO:0000252
type: Species
is: P30043
initial amount: NaN
constant: false
name: BLVRB
initial concentration: NaN
is encoded by: hsa:645
has only substance units: false

metaR GTHP
is version of: http://identifiers.org/ec-code/1.11.1.9
is: SBO:0000176
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
fast: false
modifier: MODEL1310110006#
is described by: ECO:0000134
type: Reaction
name: glutathione peroxidase
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.15
reactant: MODEL1310110006#
kinetic law: MODEL1310110006#
is version of: http://identifiers.org/ec-code/1.11.1.12
product: MODEL1310110006#

metaM but c
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: CHEBI:17968
initial amount: NaN
constant: false
name: butyrate
initial concentration: 1.0
is: HMDB00039
boundary condition: false

metaM cs a l
constant: false
boundary condition: false
is: HMDB02183
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
is: CHEBI:36005

metaM ksii core4 pre1 g
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:28067
initial amount: NaN
notes: FORMULA: C36H60N3O25X CHARGE: 0
constant: false
name: keratan sulfate II biosynthesis, precursor 1
type: Species

metaR CYTK11n
reversible: true
product: MODEL1310110006#
name: cytidylate kinase (dCMP,dGTP),nuclear
fast: false
is: SBO:0000176
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110006#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110006#

metaR Htr
reversible: true
product: MODEL1310110006#
kinetic law: MODEL1310110006#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110006#
is: SBO:0000185
fast: false
name: H transporter, endoplasmic reticulum
is described by: ECO:0000000

metaR LINOFATPtc
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of linoleic acid by the enterocytes
type: Reaction

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaM tetd7ecoa m
name: 7-tetradecenoylcoa
is: HMDB13109
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
is: SBO:0000247

metaR r2353
product: MODEL1310110006#
reactant: MODEL1310110006#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaM hexdectecoa m
initial concentration: 1.0
constant: false
is: HMDB02288
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 2,4,7,10-hexadecatetraenoylcoa
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
type: Species
has only substance units: false

metaM asn L e
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: L-asparagine
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: HMDB00168
constant: false
is: CHEBI:17196
type: Species

metaR GTHO
reversible: false
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
kinetic law: MODEL1310110006#
is described by: ECO:0000254
modifier: MODEL1310110006#
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.7
reactant: MODEL1310110006#
fast: false
product: MODEL1310110006#
name: glutathione oxidoreductase
is: SBO:0000176

metaM ksii core2 deg8 l
boundary condition: false
constant: false
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: HMDB00143
type: Species
is: CHEBI:12936
name: keratan sulfate II (core 2-linked), degradation product 8
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110006#
reactant: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaR OCD11CRNCPT2
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM 2mop c
has only substance units: false
is: HMDB01172
constant: false
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species
name: 2-methyl-3-oxopropanoate
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:57700

metaM lneldc e
initial concentration: 1.0
boundary condition: false
is: HMDB06270
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
name: linoelaidic acid (all trans C18:2)
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
type: Species

metaR HOCDACBP
kinetic law: MODEL1310110006#
product: MODEL1310110006#
reactant: MODEL1310110006#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM ksii core4 g
is: HMDB01644
name: keratan sulfate II (core 4-linked)
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:17140

http://identifiers.org/biomodels.db/MODEL1310110006#_7cae678f_5439_4f25_a8dd_9f1c10d2bc58
has only substance units: false
constant: false
is encoded by: hsa:6574
boundary condition: true
type: Species
is: Q8WUM9
initial concentration: NaN
name: SLC20A1
is: SBO:0000252
initial amount: NaN

metaM C05280 m
name: cis,cis-3,6-Dodecadienoyl-CoA
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB03952
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
type: Species
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:28002

metaR LNLNCAt
is: SBO:0000185
is described by: ECO:0000000
name: fatty acid transport via diffusion
reversible: true
reactant: MODEL1310110006#
product: MODEL1310110006#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
kinetic law: MODEL1310110006#
type: Reaction

metaM 3oddcoa m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: HMDB03937
has only substance units: false
is: CHEBI:27868
initial amount: NaN
name: 3-Oxododecanoyl-CoA
boundary condition: false
type: Species
constant: false

metaR ADKd
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110006#
reactant: MODEL1310110006#
reversible: true
is: SBO:0000176
name: adenylate kinase (d form)
is described by: ECO:0000269
modifier: MODEL1310110006#
kinetic law: MODEL1310110006#