metaR ACHtn
product: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
reactant: MODEL1310110005#
fast: false
type: Reaction
kinetic law: MODEL1310110005#
is described by: ECO:0000000
name: Acetylcholin transport, nuclear trhough pores
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_dfc70e56_787d_49a1_8bb7_11395af693c0
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8875
name: VNN2
is: SBO:0000252
boundary condition: true
type: Species
is: A8K7W0
initial amount: NaN
constant: false

metaR r2100
modifier: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM glcur e
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00127
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
name: D-glucuronate
is: CHEBI:15748
constant: false
initial amount: NaN
type: Species

metaR r2326
type: Reaction
reactant: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM uri c
constant: false
is: CHEBI:16704
is: C00299
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial amount: NaN
name: Uridine
initial concentration: 1.0
has only substance units: false
is: HMDB00296
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_ebb0ddeb_4201_4666_9285_66b6ac304bb6
initial concentration: NaN
is encoded by: hsa:8781
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: _8781_1_c
boundary condition: true

metaR CYTK4n
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110005#
fast: false
name: cytidylate kinase (dCMP,GTP),nuclear
product: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_6ec2c7e2_d6e7_4adc_b3a7_4aa880cc85db
type: Species
has only substance units: false
is: P28329
is encoded by: hsa:1103
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
name: CHAT
initial concentration: NaN

metaR r1831
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: false
modifier: MODEL1310110005#
product: MODEL1310110005#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_7e129095_18fd_47f7_b649_e7fca3f20a07
boundary condition: true
type: Species
name: _642502_1_c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:642502
constant: false
has only substance units: false

metaR DNDPt22m
modifier: MODEL1310110005#
name: dTDP transport via dUDP antiport
fast: false
product: MODEL1310110005#
is: SBO:0000185
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaM nmn c
is: HMDB00229
is: C00455
is: CHEBI:14649
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
constant: false
boundary condition: false
initial concentration: 1.0
name: NMN
initial amount: NaN

metaM acgam r
initial amount: NaN
is: SBO:0000247
is: CHEBI:17411
type: Species
has only substance units: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
boundary condition: false
constant: false
name: N-acetyl-D-glucosamine
initial concentration: 1.0
is: HMDB00215

http://identifiers.org/biomodels.db/MODEL1310110005#_2ec19de4_a348_4580_b9d0_5a870d9ebf35
is: Q9BZX2
is encoded by: hsa:7371
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: UCK2
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_a3a830db_d9f6_4ac1_94ae_5fc585176fbc
initial concentration: NaN
boundary condition: true
type: Species
is: P04746
is encoded by: hsa:279
name: AMY2A
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR r2327
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
product: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

metaR r2101
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_dc8f0faa_61c7_437e_b8ad_ebc958cfadfd
is encoded by: hsa:2027
initial amount: NaN
has only substance units: false
is: P13929
name: ENO3
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaM datp n
name: dATP
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:61404
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
is: C00131

metaR ASCBt
reversible: true
reactant: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
kinetic law: MODEL1310110005#
is: SBO:0000185
name: L-ascorbate transport via facilitated diffusion

http://identifiers.org/biomodels.db/MODEL1310110005#_5310df2e_39a1_4d30_a34b_e9483348788d
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
name: _T83654_1_c
initial concentration: NaN
boundary condition: true
is encoded by: hsa:T83654

http://identifiers.org/biomodels.db/MODEL1310110005#_6cf50191_d966_44f6_bd9d_a63efaccf982
type: Species
boundary condition: true
is: Q9H0N5
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:84105
constant: false
name: PCBD2

http://identifiers.org/biomodels.db/MODEL1310110005#_8328d9ce_3dff_426a_ae00_24a0cb33026e
constant: false
initial amount: NaN
type: Species
name: _U37519_1_c
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:U37519

metaM glx x
name: glyoxylate
is: CHEBI:36655
boundary condition: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: HMDB00119
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_614a3774_e316_41bb_b4b0_fb5530e9ad08
has only substance units: false
is: P09972
initial amount: NaN
type: Species
is: SBO:0000252
name: ALDOC
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:230

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaR r2324
reversible: true
fast: false
kinetic law: MODEL1310110005#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM h r
is: C00080
constant: false
is: CHEBI:24636
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
is: http://identifiers.org/pubchem.compound/3380

metaR O2Stm
is: SBO:0000185
reactant: MODEL1310110005#
name: superoxide anion transport via diffusion (mitochondria)
type: Reaction
kinetic law: MODEL1310110005#
reversible: true
is described by: ECO:0000000
product: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_3805d6a0_f28a_4c04_9c44_c4f92c1c5221
initial concentration: NaN
boundary condition: true
type: Species
name: LDHAL6B
constant: false
has only substance units: false
is: Q9BYZ2
is encoded by: hsa:92483
initial amount: NaN
is: SBO:0000252

metaR O2Stn
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reactant: MODEL1310110005#
is: SBO:0000185
fast: false
product: MODEL1310110005#
name: superoxide anion transport via diffusion (nucleus)
reversible: true
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_22832514_68ce_40fc_a512_0a67b48d67e3
type: Species
boundary condition: true
has only substance units: false
is: B7Z7I0
name: TKTL1
is encoded by: hsa:8277
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false

metaR RE2999M
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
reactant: MODEL1310110005#
is: SBO:0000176
fast: false
product: MODEL1310110005#
name: RE2999
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_9ba1cb1f_5fe7_4011_b614_0bbbd970cdd4
initial amount: NaN
initial concentration: NaN
type: Species
name: PECR
is: Q9BY49
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:55825
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_4b573117_439f_4653_ba74_f710007ab33f
initial concentration: NaN
is encoded by: hsa:1103
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: D3DX95
name: CHAT
has only substance units: false
constant: false
type: Species

metaM HC02204 e
name: prostaglandin-b1
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:27624
is: SBO:0000247
type: Species
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial amount: NaN

metaR r0456
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
reversible: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110005#
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
is version of: http://identifiers.org/ec-code/2.7.1.32
is: SBO:0000176
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaR THRD L
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES:Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....
fast: false
reversible: false
modifier: MODEL1310110005#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
name: L-threonine deaminase
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.1.17

metaM gchola c
name: glycocholate
initial concentration: 1.0
is: CHEBI:58235
is: SBO:0000247
initial amount: NaN
is: HMDB00138
has only substance units: false
boundary condition: false
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_761070c4_2bde_4b45_aa71_8ecf33d73d78
type: Species
boundary condition: true
name: ELOVL2
initial concentration: NaN
constant: false
is encoded by: hsa:54898
is: Q9NXB9
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_6dee8599_8529_4623_9c05_0aefc5c3f3ab
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI285872
type: Species
name: _AI285872_1_c

metaM dmnoncrn c
is: HMDB06202
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: 4,8-dimethylnonanoyl carnitine
constant: false
notes: FORMULA: C18H37NO4 CHARGE: 0
has only substance units: false
type: Species
is: SBO:0000247

metaR r2325
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
reversible: true

metaR r0166
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110005#
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
fast: false

metaM h2o l
type: Species
is: CHEBI:15377
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
is: HMDB02111
name: water
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial concentration: 1.0

metaR BILDGLCURt
modifier: MODEL1310110005#
product: MODEL1310110005#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport

metaR r0963
fast: false
type: Reaction
product: MODEL1310110005#
name: Facilitated diffusion
reactant: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
reversible: false
kinetic law: MODEL1310110005#
is described by: ECO:0000000

metaR THBPT4ACAMDASE
modifier: MODEL1310110005#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
kinetic law: MODEL1310110005#
type: Reaction
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
fast: false
reactant: MODEL1310110005#

metaM HC01434 m
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: SBO:0000247
has only substance units: false
is: CHEBI:58931
name: oxalatosuccinate(3-)
boundary condition: false
constant: false

metaR r2104
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110005#
fast: false
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_3fc8a61e_9e2a_4a0e_ad72_94a09b6d1305
is: SBO:0000252
name: _AI601100_1_m
type: Species
boundary condition: true
is encoded by: hsa:AI601100
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

metaM oaa c
name: Oxaloacetate
is: HMDB00223
constant: false
notes: FORMULA: C4H2O5 CHARGE: -2
is: C00036
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:3338
is: SBO:0000247
has only substance units: false

metaM HC02204 c
initial amount: NaN
initial concentration: 1.0
constant: false
name: prostaglandin-b1
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: CHEBI:27624
has only substance units: false
type: Species
boundary condition: false

metaR HDCAtr
reversible: true
is: SBO:0000185
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
name: fatty acid transport via diffusion
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaR 3SPYRSP
is described by: ECO:0000000
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110005#
name: 3-sulfinopyruvate hydrolase (spotaneous reaction)

metaR GLCURter
type: Reaction
name: glucuronate endoplasmic reticular transport
fast: false
product: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110005#
is described by: ECO:0000000

metaR CHATn
is described by: ECO:0000269
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
reversible: true
reactant: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.6
fast: false
name: Choline O-acetyltransferase

metaM CE1926 e
is: CHEBI:15748
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
is: SBO:0000247
type: Species
is: HMDB00127
initial amount: NaN
boundary condition: false
name: gama-carboxyethyl-hydroxychroman

metaM for e
is: SBO:0000247
name: formate
initial concentration: 1.0
is: HMDB00142
is: CHEBI:15740
has only substance units: false
constant: false
type: Species
boundary condition: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_d1a745fc_6a31_41a5_8b17_620bfa9e2f3f
is encoded by: hsa:2821
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: GPI
type: Species
is: P06744
constant: false
has only substance units: false
initial concentration: NaN

metaM tsul c
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: SBO:0000247
is: CHEBI:16094
name: thiosulfate(2-)
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00257

metaR C226CPT1
is described by: ECO:0000000
kinetic law: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110005#
product: MODEL1310110005#
modifier: MODEL1310110005#
is: SBO:0000176
name: carnitine C22:6 transferase
reversible: false
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
fast: false

metaM HC00718 c
type: Species
is: SBO:0000247
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: N-methylethanolaminium phosphate(1-)
is: CHEBI:57781

metaR r0450
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.3
reactant: MODEL1310110005#
modifier: MODEL1310110005#
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_6df01895_3b15_4e8c_89f2_041fce9e46cb
is: Q5JPH6
name: EARS2
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:124454
is: SBO:0000252

metaM h2o m
is: SBO:0000247
boundary condition: false
name: H2O
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
type: Species
initial amount: NaN
is: HMDB02111
is: C00001
initial concentration: 1.0
constant: false

metaM 4ppcys m
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB01117
constant: false
is: CHEBI:59458
initial concentration: 1.0
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
has only substance units: false
type: Species

metaR r1150
fast: false
is: SBO:0000185
modifier: MODEL1310110005#
product: MODEL1310110005#
reversible: false
name: Facilitated diffusion
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
type: Reaction

metaR r2105
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false

metaM for c
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
boundary condition: false
is: CHEBI:15740
initial concentration: 1.0
has only substance units: false
is: HMDB00142
name: Formate
is: C00058
type: Species

metaR DNDPt41m
kinetic law: MODEL1310110005#
name: dUTP transport via dCDP antiport
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is: SBO:0000185
type: Reaction
reversible: false
is described by: ECO:0000269

metaR RE1845C
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: true
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110005#
name: RE1845
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
reactant: MODEL1310110005#

metaM gchola e
boundary condition: false
name: glycocholate
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C26H43NO6 CHARGE: 0
is: HMDB00138
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_47b2e111_3c4b_4393_90f7_ec3c3535e262
constant: false
initial amount: NaN
name: PGK1
is encoded by: hsa:5230
is: SBO:0000252
boundary condition: true
is: P00558
initial concentration: NaN
has only substance units: false
type: Species

metaM sarcs c
is: HMDB00271
notes: FORMULA: C3H7NO2 CHARGE: 0
constant: false
has only substance units: false
is: CHEBI:3513
is: C00213
initial amount: NaN
is: SBO:0000247
name: Sarcosine
boundary condition: false
initial concentration: 1.0
type: Species

metaM rbt c
is: CHEBI:15963
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: HMDB00508
type: Species
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
name: D-ribitol

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

metaM HC01399 m
type: Species
constant: false
boundary condition: false
is: CHEBI:27466
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
name: (S)-3-Hydroxytetradecanoyl-CoA

metaM h2o n
is: HMDB02111
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:15377
constant: false
name: water
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247

metaM uri e
is: SBO:0000247
is: C00299
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
name: Uridine
initial concentration: 1.0
type: Species
is: HMDB00296
is: CHEBI:16704
has only substance units: false
constant: false

metaR 1PPDCRp
product: MODEL1310110005#
name: delta1-piperideine-2-carboxylate reductase, perixosomal
reversible: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
fast: false

metaM datp m
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: CHEBI:61404
boundary condition: false
is: C00131
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB01532
has only substance units: false
type: Species
name: dATP
initial concentration: 1.0

metaM 3ump e
boundary condition: false
name: 3'-UMP(2-)
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-3-4-7(20-21(16,17)18)6(14)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 EHMN_ABBREVIATION: C01368
is: CHEBI:60784
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_1dad8385_b70e_4908_a9d8_ca5c2d37e773
initial concentration: NaN
constant: false
type: Species
name: CA14
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:23632
is: A8K3J4
is: SBO:0000252

metaR MECOAS1m
is version of: http://identifiers.org/ec-code/6.2.1.4
name: mesaconate--CoA ligase (GDP-forming)
product: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is: SBO:0000176
is described by: ECO:0000304
fast: false
reversible: true

metaR r2102
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
modifier: MODEL1310110005#
fast: false
reactant: MODEL1310110005#

metaR r2328
is: SBO:0000185
type: Reaction
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
product: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_56b096b2_7346_47ad_b110_a99eac3125d1
constant: false
initial amount: NaN
is: Q96KH8
is: SBO:0000252
boundary condition: true
has only substance units: false
name: SLC6A2
type: Species
initial concentration: NaN
is encoded by: hsa:6530

http://identifiers.org/biomodels.db/MODEL1310110005#_2a7c65cf_95b0_49ac_ab25_7320e5895ffe
is: Q6LEN5
name: CHAT
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:1103

metaR DURItn
kinetic law: MODEL1310110005#
name: deoxyuridine transport in nucleus
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110005#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110005#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_4db1effa_609b_4900_985b_fb360dc53fdf
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: P50053
name: KHK
is encoded by: hsa:3795
initial amount: NaN

metaR ENO
is version of: http://identifiers.org/ec-code/4.2.1.11
notes: GENE_ASSOCIATION: (2023.1) or (2027.2) or (2027.1) or (2026.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.2.1.11 Confidence Level: 0 AUTHORS: PMID:5939,PMID:6626557 NOTES:SMP
kinetic law: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110005#
name: enolase
is described by: ECO:0000134
reversible: true
fast: false
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_abd1a7d2_d303_4418_b73e_c5a62c10e1a7
boundary condition: true
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is: P48735
initial concentration: NaN
is encoded by: hsa:3418
name: IDH2
initial amount: NaN

metaR r2103
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
product: MODEL1310110005#
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#

metaR RE3326M
type: Reaction
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.2.4.4
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110005#
is: SBO:0000176
name: RE3326
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaM dhap e
constant: false
name: glycerone phosphate(2-)
is: HMDB01473
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: SBO:0000247
type: Species
is: CHEBI:57642
initial amount: NaN
boundary condition: false

metaM prostgi2 r
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335
name: prostaglandin I2(1-)
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: CHEBI:57403
boundary condition: false
initial concentration: 1.0

metaR r0451
reversible: false
kinetic law: MODEL1310110005#
is: SBO:0000176
reactant: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) Lysine degradation EC:1.2.4.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
fast: false
is described by: ECO:0000000

metaM rbt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
name: D-ribitol
is: CHEBI:15963
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00508
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM sarcs e
is: HMDB00271
constant: false
is: CHEBI:15611
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
name: sarcosine
type: Species
initial concentration: 1.0

metaM duri n
boundary condition: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
name: 2'-deoxyuridine
initial amount: NaN
has only substance units: false
is: CHEBI:16450
initial concentration: 1.0
is: SBO:0000247
is: HMDB00012
type: Species
constant: false

metaR r2329
type: Reaction
reactant: MODEL1310110005#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
kinetic law: MODEL1310110005#

metaR RE2626C
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110005#
kinetic law: MODEL1310110005#
name: RE2626
is: SBO:0000176
fast: false
reactant: MODEL1310110005#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_488cadbc_5be8_4640_ab0e_1f21c0c40fb9
initial amount: NaN
name: ACOX1
boundary condition: true
is encoded by: hsa:51
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is: B4DK61

metaM e4p c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
name: D-Erythrose 4-phosphate
boundary condition: false
is: C00279
is: SBO:0000247
is: CHEBI:16897
is: HMDB01321
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_ecb19dcf_3ea9_4299_971d_e08c96c64cc8
has only substance units: false
is encoded by: hsa:10935
initial amount: NaN
is: E9PH29
constant: false
boundary condition: true
name: PRDX3
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r2532
product: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
type: Reaction

metaM dgchol c
initial amount: NaN
is: HMDB00637
has only substance units: false
constant: false
is: CHEBI:36252
initial concentration: 1.0
type: Species
name: glycochenodeoxycholate
is: SBO:0000247
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_da87be06_1b7f_412f_af84_08a0b7b88945
boundary condition: true
constant: false
initial amount: NaN
name: GPT2
is encoded by: hsa:84706
is: Q8TD30
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

metaR r1602
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110005#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM HC01231 m
has only substance units: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: CHEBI:58480
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
name: N-[(R)-pantothenoyl]-L-cysteinate

metaR r0160
fast: false
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.1.3.2
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51

http://identifiers.org/biomodels.db/MODEL1310110005#_52fabdeb_03fd_4e73_92c1_0540d60a89a8
boundary condition: true
is: Q9UBM1
is encoded by: hsa:10400
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: PEMT

metaM CE2839 e
has only substance units: false
name: maltodecaose
initial amount: NaN
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
constant: false
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
initial concentration: 1.0
is: C01936
type: Species
is: SBO:0000247

metaM dcyt e
initial amount: NaN
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
has only substance units: false
is: CHEBI:15698
is: HMDB00014
is: C00881
type: Species
is: SBO:0000247
initial concentration: 1.0
name: Deoxycytidine
boundary condition: false

metaR r0517
is described by: ECO:0000000
product: MODEL1310110005#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reactant: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true
is version of: http://identifiers.org/ec-code/1.17.4.1
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
type: Reaction
kinetic law: MODEL1310110005#

metaM dhap c
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3411
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB01473
initial amount: NaN
type: Species
constant: false
name: Dihydroxyacetone phosphate
is: C00111
is: CHEBI:57642

metaM btcoa m
is: C00136
boundary condition: false
is: CHEBI:57371
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
name: Butanoyl-CoA
initial amount: NaN
is: SBO:0000247
is: HMDB01088
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136

metaR 3AIBtm
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.6.1.19
name: 3-amino-isobutyrate transport, mitochondrial

metaR r1154
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
reactant: MODEL1310110005#
reversible: true
fast: false
product: MODEL1310110005#
name: EC:1.2.7.2
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110005#

metaM phe L m
initial amount: NaN
type: Species
is: CHEBI:17295
is: SBO:0000247
boundary condition: false
is: HMDB00159
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
name: L-phenylalanine
has only substance units: false
initial concentration: 1.0
constant: false

metaR SERDGLNexR
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000304
modifier: MODEL1310110005#
is: SBO:0000185
name: D-Serine/Glutamine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
reversible: true
fast: false

metaR ANTHte
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110005#
name: Transport of anthranilate
product: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaM HC02210 e
boundary condition: false
initial concentration: 1.0
name: prostaglandin-d3
type: Species
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:34939

metaR RE0935E
fast: false
is: SBO:0000176
name: RE0935
reversible: true
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
is version of: http://identifiers.org/ec-code/3.2.1.1
product: MODEL1310110005#
kinetic law: MODEL1310110005#

metaR CYANt
type: Reaction
is: SBO:0000185
fast: false
name: Cyanide transport via diffusion (extracellular to cytosol)
reversible: true
reactant: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
is described by: ECO:0000000

metaM tsul m
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00257
name: thiosulfate(2-)
type: Species
initial concentration: 1.0
is: CHEBI:16094
boundary condition: false
has only substance units: false

metaM HC01712 m
type: Species
notes: FORMULA: C13H22NO4S2 CHARGE: -1 INCHI: InChI=1S/C13H23NO4S2/c14-11(15)5-2-1-4-10(19)8-9-20-13(18)7-3-6-12(16)17/h10,19H,1-9H2,(H2,14,15)(H,16,17) EHMN_ABBREVIATION: C06157
is: SBO:0000247
constant: false
boundary condition: false
name: S-Glutaryldihydrolipoamide
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28391
has only substance units: false

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_f91d0ca4_d87d_4f00_9591_a0fbfa167d3e
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
name: _2544_1_c
type: Species
initial amount: NaN
is encoded by: hsa:2544

http://identifiers.org/biomodels.db/MODEL1310110005#_a387e617_0d90_418c_948d_672e7156dbd4
is: Q9UF12
is encoded by: hsa:58510
name: PRODH2
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR r1600
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR CDSm
reversible: false
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
type: Reaction
name: phosphatidate cytidylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.41

http://identifiers.org/biomodels.db/MODEL1310110005#_a4a687f0_a8f4_4c8b_9641_88e242438d12
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252
name: _AI024818_1_c
is encoded by: hsa:AI024818
initial concentration: NaN

metaR C226CPT2
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
name: C226 transport into the mitochondria
product: MODEL1310110005#
is: SBO:0000176
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_33196a5e_c434_407e_9690_ed0f56fdaa4b
name: SLC26A9
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:115019
initial concentration: NaN
is: B3KXK1
has only substance units: false
boundary condition: true

metaR r1156
fast: false
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_15e2635d_7920_4ef0_a3df_52bc3dd58ef0
initial amount: NaN
boundary condition: true
name: COX6B1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1340
type: Species
constant: false
is: P14854

metaM retinal cis 13 r
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB06220
is: SBO:0000247
has only substance units: false
is: CHEBI:45487
name: 13-cis-retinal
initial amount: NaN

metaM h2o c
is: HMDB02111
type: Species
notes: FORMULA: H2O CHARGE: 0
initial concentration: 1.0
is: CHEBI:3303
boundary condition: false
name: H2O
has only substance units: false
constant: false
is: C00001
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_eaf5b454_56d1_4971_861e_6e1422124e8e
is: P36021
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
name: SLC16A2
initial amount: NaN
is encoded by: hsa:6567

http://identifiers.org/biomodels.db/MODEL1310110005#_fe0ef3fd_21cc_4040_beb7_408743420f49
name: CPT1B
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: Q92523
boundary condition: true
is encoded by: hsa:1375
is: SBO:0000252

metaM pyr m
boundary condition: false
is: C00022
is: CHEBI:15361
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: http://identifiers.org/pubchem.compound/3324
initial concentration: 1.0
name: pyruvate
is: SBO:0000247
type: Species

metaM HC02210 c
name: prostaglandin-d3
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:34939

http://identifiers.org/biomodels.db/MODEL1310110005#_b00c51c2_ca0e_4006_b0e6_4d1003803279
has only substance units: false
name: GLRX2
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:51022
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_96497ed6_8a96_4407_ac4c_ed94a6a87f84
initial concentration: NaN
is encoded by: hsa:65010
name: SLC26A6
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is: Q9Y3Y1

metaR RE2954C
name: RE2954
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.1.40
reactant: MODEL1310110005#
reversible: true
is: SBO:0000176

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_dffadf7a_0da0_4c0a_ab29_425d3332b976
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4696
name: NDUFA3
initial concentration: NaN
constant: false
boundary condition: true
is: O95167
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_0f6c9408_9681_4a89_81bf_913586b3c8eb
has only substance units: false
constant: false
name: UEVLD
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:55293
is: SBO:0000252
boundary condition: true
is: Q8IX04

metaR 3MOBte
fast: false
name: Transport of 3-methyl-2-oxobutanoate
product: MODEL1310110005#
type: Reaction
reversible: true
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110005#

metaR RE1254C
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
name: RE1254
product: MODEL1310110005#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
is: SBO:0000176
is described by: ECO:0000000

metaM HC00695 m
name: S-Succinyldihydrolipoamide
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
is: CHEBI:17432
initial amount: NaN
constant: false

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_b8fe0eec_f308_4fbf_8f0c_b86d883ca362
boundary condition: true
type: Species
is: P00338
name: LDHA
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:3939
has only substance units: false

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

metaM HC02213 e
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
name: prostaglandin-e3
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:28031

metaM h2o e
is: C00001
has only substance units: false
boundary condition: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
type: Species
is: CHEBI:15377
is: HMDB02111
name: H2O
initial concentration: 1.0
initial amount: NaN
constant: false

metaM cdpdag hs c
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:58332
initial concentration: 1.0
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: SBO:0000247
constant: false
name: CDP-diacylglycerol(2-)

metaM h m
constant: false
is: SBO:0000247
type: Species
name: proton
initial amount: NaN
is: C00080
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380

http://identifiers.org/biomodels.db/MODEL1310110005#_af7570e5_bcd6_4cd3_90a5_b8db7f9ea1ec
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55349
type: Species
initial amount: NaN
boundary condition: true
name: CHDH
is: Q8NE62

metaR r2537
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000185
type: Reaction
product: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110005#
name: Utilized transport
is described by: ECO:0000000

metaM duri c
has only substance units: false
type: Species
initial concentration: 1.0
name: Deoxyuridine
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450
is: HMDB00012
is: C00526

metaR FATP3t
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reversible: true
product: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
name: fatty acid electroneutral transport
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_673a78d8_d80d_4a3d_9eb9_d45cd54d784a
is encoded by: hsa:223
has only substance units: false
constant: false
name: ALDH9A1
initial concentration: NaN
is: P49189
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species

metaM sucsal m
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
has only substance units: false
constant: false
name: Succinic semialdehyde
is: HMDB01259
initial amount: NaN
type: Species
is: CHEBI:57706
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR r0853
product: MODEL1310110005#
reversible: false
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
kinetic law: MODEL1310110005#
name: Facilitated diffusion

metaR 5ADTSTSTERONEtr
reactant: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
kinetic law: MODEL1310110005#
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
name: 5 alpha dihydrotesterone intracellular transport
type: Reaction

metaR FAOXC18480m
reversible: false
product: MODEL1310110005#
reactant: MODEL1310110005#
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR r0236
is described by: ECO:0000000
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.6
fast: false
type: Reaction
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: true
modifier: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:

metaM dha e
initial concentration: 1.0
is: CHEBI:16016
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
is: HMDB01882
boundary condition: false
type: Species
name: glycerone
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false

metaM h n
is: CHEBI:24636
boundary condition: false
initial amount: NaN
name: proton
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species

metaM guln r
boundary condition: false
has only substance units: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: HMDB03290
type: Species
initial concentration: 1.0
is: SBO:0000247
name: L-gulonate
initial amount: NaN
constant: false
is: CHEBI:13115

metaM glcur c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00127
initial amount: NaN
is: CHEBI:15748
name: D-glucuronate
boundary condition: false
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191

metaR O2tp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
name: O2 transport, peroxisomal
is: SBO:0000185
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_8203be44_eef7_4b7d_8159_4af07433687a
has part: P07327
name: ADH1A:ADH1B
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:124
boundary condition: true
is: SBO:0000297
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_97bb8a19_45bb_4386_b0ca_484ebb99e0ec
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true
name: _R51273_1_c
is: SBO:0000252
is encoded by: hsa:R51273
has only substance units: false

metaM oaa m
is: C00036
boundary condition: false
type: Species
is: CHEBI:16452
is: HMDB00223
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
constant: false
has only substance units: false
name: Oxaloacetate
is: SBO:0000247

metaM retinal c
type: Species
has only substance units: false
is: CHEBI:15035
is: HMDB01358
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
name: retinal
initial concentration: 1.0
constant: false

metaR r2534
type: Reaction
is: SBO:0000185
reactant: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR PI4P5Kn
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
product: MODEL1310110005#
is: SBO:0000176
name: phosphatidylinositol 4-phosphate 5-kinase, nuclear
is described by: ECO:0000000
reactant: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
type: Reaction

metaM 12ppd S c
has only substance units: false
boundary condition: false
name: (S)-propane-1,2-diol
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
is: CHEBI:29002
is: HMDB06213
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_a9d5b334_b910_4fc8_bc30_b75369d0af82
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:130
boundary condition: true
name: ADH6
is: P28332
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_5afdd0c5_5a22_412a_8302_dfa78907edbc
is encoded by: hsa:57665
boundary condition: true
name: RDH14
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: Q9HBH5

http://identifiers.org/biomodels.db/MODEL1310110005#_215ce9e3_660f_4dd6_bce1_7f6e4ee0d521
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _AI620219_1_m
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI620219

metaM HC02213 c
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
is: CHEBI:28031
name: prostaglandin-e3

metaR EBP1r
is version of: http://identifiers.org/ec-code/5.3.3.5
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
is: SBO:0000176
modifier: MODEL1310110005#
reactant: MODEL1310110005#
reversible: false
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ
type: Reaction
is described by: ECO:0000134
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#

metaM sarcs m
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
has only substance units: false
initial amount: NaN
name: Sarcosine
is: HMDB00271
type: Species
constant: false
is: SBO:0000247
is: C00213
is: CHEBI:15611
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_29f157a0_a98e_4f87_a9da_ba061d78325e
is encoded by: hsa:5172
initial amount: NaN
type: Species
is: O43511
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
name: SLC26A4

http://identifiers.org/biomodels.db/MODEL1310110005#_c92ba7d7_6ff2_4e99_8a5d_bb1c98fc0bd6
is: E5KSL6
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1716
name: DGUOK
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
constant: false

metaM duri e
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
name: Deoxyuridine
is: SBO:0000247
boundary condition: false
is: CHEBI:16450
is: HMDB00012
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: C00526

metaR r2535
reactant: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
is: SBO:0000185
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_42e050af_e08c_42f5_b850_f69573898ca7
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
name: CPT1B
is encoded by: hsa:1375
is: B7Z5T8
boundary condition: true
initial concentration: NaN
constant: false

metaM dcyt c
is: CHEBI:15698
constant: false
name: Deoxycytidine
boundary condition: false
is: C00881
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00014

metaM 3mop m
is: SBO:0000247
boundary condition: false
is: CHEBI:28654
initial amount: NaN
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
type: Species
constant: false
initial concentration: 1.0
name: 3-methyl-2-oxopentanoate
is: HMDB00491
has only substance units: false

metaR r0679
is: SBO:0000176
reversible: true
modifier: MODEL1310110005#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
kinetic law: MODEL1310110005#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reactant: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
fast: false

metaR r0735
is: SBO:0000176
reversible: true
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
fast: false
kinetic law: MODEL1310110005#
type: Reaction
modifier: MODEL1310110005#

metaR EX ins LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Inosine exchange
type: Reaction

metaR EX glyb LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycine betaine exchange
type: Reaction

metaR ASCBOX
fast: false
name: ascorbic acid oxidase
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_480c2178_9c14_4419_b66c_51fbed39c47d
is encoded by: hsa:6390
name: SDHB
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is: P21912
constant: false
type: Species
initial concentration: NaN

metaM eicostet e
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1
is: CHEBI:36033
initial concentration: 1.0
has only substance units: false
is: HMDB02177
is: SBO:0000247
constant: false
name: eicosatetranoic acid
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_d3401205_a524_410e_9765_99600785d983
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:1841
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is: P23919
name: DTYMK

metaR 3HBCOAHLm
fast: false
reactant: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110005#
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM

metaR FAOXC101C8m
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaM tdcoa c
initial concentration: 1.0
is: C02593
boundary condition: false
has only substance units: false
is: CHEBI:57385
is: SBO:0000247
type: Species
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial amount: NaN
constant: false
is: HMDB01521
name: Tetradecanoyl-CoA (n-C14:0CoA)

metaR RE0958E
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
reversible: true
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0958

metaR CYTDtm
is: SBO:0000185
name: cytidine facilated transport in mitochondria
modifier: MODEL1310110005#
is described by: ECO:0000269
fast: false
product: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
reactant: MODEL1310110005#

metaM CE5120 m
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
name: trans-2-cis-8-tetradecadienoyl-CoA
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:12947
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM q10 e
has only substance units: false
initial amount: NaN
constant: false
name: ubiquinone-10
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: CHEBI:46245
is: SBO:0000247
is: HMDB01072

metaM HC02208 c
name: prostaglandin-d1
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:27696
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_d92b2a74_ceda_4312_86c7_f3a9f37b5292
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
name: PECR
type: Species
boundary condition: true
is encoded by: hsa:55825
initial amount: NaN
is: Q9BY49

metaR r0734
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
fast: false
is: SBO:0000176
product: MODEL1310110005#
reversible: false
reactant: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110005#

metaR RE3565C
is described by: ECO:0000000
product: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
fast: false
type: Reaction
reversible: true
name: RE3565
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110005#

metaM adn c
is: SBO:0000247
type: Species
is: HMDB00050
initial amount: NaN
is: CHEBI:16335
constant: false
has only substance units: false
name: Adenosine
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
boundary condition: false
initial concentration: 1.0
is: C00212

metaR r0913
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110005#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110005#_24074f29_9fb4_4bf1_a1ba_26ddc3137d3c
type: Species
constant: false
name: TK2
is: SBO:0000252
initial concentration: NaN
is: O00142
initial amount: NaN
is encoded by: hsa:7084
boundary condition: true
has only substance units: false

metaR DGSNt
fast: false
reversible: true
name: deoyguanosine transport via diffusion
is described by: ECO:0000000
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
type: Reaction

metaR 2AMADPTm
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
kinetic law: MODEL1310110005#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_e8568331_5da5_4d3c_ba37_6019e2c92332
is: Q8NFW8
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55907
initial amount: NaN
type: Species
name: CMAS
initial concentration: NaN
constant: false

metaR URIDK2m
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT
type: Reaction
fast: false
name: uridylate kinase (dUMP), mitochondrial

metaR r1979
is: SBO:0000185
kinetic law: MODEL1310110005#
name: Y+LAT2 Utilized transport
product: MODEL1310110005#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110005#_6d1f0c72_0d70_424a_b496_2d14449dd2dc
type: Species
constant: false
initial concentration: NaN
is: Q8IZV5
boundary condition: true
initial amount: NaN
name: RDH10
has only substance units: false
is encoded by: hsa:157506
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_ff971844_042c_4fc4_9954_a0b5768f4f04
has only substance units: false
is encoded by: hsa:AI926493
initial amount: NaN
type: Species
name: _AI926493_1_m
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaM prostgi2 e
initial amount: NaN
is: CHEBI:57403
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
boundary condition: false
constant: false
type: Species
is: HMDB01335
name: prostaglandin I2(1-)
has only substance units: false

metaM hco3 m
name: Bicarbonate
has only substance units: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: HMDB00595
constant: false
type: Species
is: CHEBI:17544
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C00288

metaM eicostet c
type: Species
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:36033
name: eicosatetranoic acid
is: HMDB02177
is: SBO:0000247
constant: false

metaR CYTK9n
product: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
name: cytidylate kinase (CMP,dCTP),nuclear
modifier: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaM 56dura c
is: HMDB00076
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: 5,6-dihydrouracil
type: Species
boundary condition: false
constant: false
is: CHEBI:15901
initial amount: NaN

metaM q10 c
name: ubiquinone-10
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: CHEBI:46245
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: SBO:0000247
is: HMDB01072
has only substance units: false

metaR r0733
fast: false
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110005#
type: Reaction
reversible: false
modifier: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.12
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is described by: ECO:0000000
product: MODEL1310110005#
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_e01b25f3_f1c1_4656_876e_e264ae33bfdb
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3795
is: Q6IBK2
has only substance units: false
name: KHK
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_6559b474_df61_4b6d_91d1_8bcd3acf49b2
is: SBO:0000252
boundary condition: true
is: B4DYG5
type: Species
constant: false
name: PI4KA
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:5297

metaR r0911
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
name: Facilitated diffusion
product: MODEL1310110005#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_251d0315_28a4_4843_82e9_d21f84f17177
name: _H17063_1_m
constant: false
boundary condition: true
is encoded by: hsa:H17063
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_405a4539_b0ab_494b_98bb_9cd0f5ae80c6
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: SDHC
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:6391
is: Q99643

metaR FBA
fast: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176
type: Reaction
reversible: true
reactant: MODEL1310110005#
is described by: ECO:0000134
modifier: MODEL1310110005#
name: fructose-bisphosphate aldolase
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:12626877,PMID:6765112 NOTES:6765112 - fluorescence of presence in human brain
is version of: http://identifiers.org/ec-code/4.1.2.13

metaR 3AIBt
type: Reaction
product: MODEL1310110005#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
name: 3-amino-isobutyrate transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT

metaR GLYCtm
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
type: Reaction
kinetic law: MODEL1310110005#
name: glycerol transport
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110005#
is described by: ECO:0000000

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaR NCAMUP
type: Reaction
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
is described by: ECO:0000000
fast: false
product: MODEL1310110005#
name: Nicotinamide acid uptake

http://identifiers.org/biomodels.db/MODEL1310110005#_03e08ec7_d3f8_4852_8ea4_b21bc2595ba4
initial amount: NaN
name: SLC6A10P
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:386757

metaM btcoa c
boundary condition: false
is: CHEBI:57371
is: HMDB01088
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: C00136
initial concentration: 1.0
has only substance units: false
name: Butanoyl-CoA
initial amount: NaN

metaR ACOAD1fm
product: MODEL1310110005#
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
type: Reaction
modifier: MODEL1310110005#
is: SBO:0000176
fast: false
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)

metaM HC01434 c
is: CHEBI:58931
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
has only substance units: false
is: SBO:0000247
name: oxalatosuccinate(3-)
boundary condition: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaM dcyt n
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
name: 2'-deoxycytidine
is: HMDB00014
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:15698
boundary condition: false

metaR r0732
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110005#
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110005#

metaM prostgi2 c
initial concentration: 1.0
is: CHEBI:57403
name: prostaglandin I2(1-)
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: HMDB01335
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312

metaR FUMSO4tm
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
name: Fumarate:sulfate antiport, mitochondrial
reactant: MODEL1310110005#
is: SBO:0000185
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#

metaM tdchola c
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:9407
constant: false
initial concentration: 1.0
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
has only substance units: false
is: HMDB00951
name: taurochenodeoxycholate

metaR CYSTSERex
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110005#
is: SBO:0000185
name: L-cystine/glycine exchanger (cystine in)
fast: false
notes: GENE_ASSOCIATION: (6519.1 and 11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:SAB see PMID 14770310
product: MODEL1310110005#
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110005#_3dc0c40d_8aac_479c_8789_9ef5dcdf089e
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: _NOS2A_1_c
is encoded by: hsa:NOS2A

metaR r0860
is version of: http://identifiers.org/ec-code/4.1.2.27
name: Utilized transport
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110005#
reversible: true
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_a14297fe_43e7_48f3_a387_bdfff49dbbeb
constant: false
initial concentration: NaN
type: Species
name: HADHA
boundary condition: true
is: E9KL44
is encoded by: hsa:3030
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR NCNt
is: SBO:0000185
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
reactant: MODEL1310110005#
type: Reaction
is described by: ECO:0000269
reversible: true
name: Na+/Ca2+-NH4+ exchange
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_f6fc71ff_b30c_4659_8a5c_512b03167a69
is: SBO:0000252
initial amount: NaN
name: ADSL
is encoded by: hsa:158
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
constant: false

metaM tyr L c
is: CHEBI:17895
initial amount: NaN
is: HMDB00158
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: L-tyrosine
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
constant: false
is: SBO:0000247

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR LALDO2x
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:AMF
reversible: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110005#
name: D-Lactaldehyde:NAD+ 1-oxidoreductase
fast: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000176
modifier: MODEL1310110005#

metaR RE3218C
product: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
name: RE3218
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.2
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176
type: Reaction

metaR r0917
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
fast: false
is described by: ECO:0000000
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110005#

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR r1377
reversible: true
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110005#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
is: SBO:0000176
type: Reaction
product: MODEL1310110005#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_99b903ea_d731_40b9_bf1a_5ccc65e0fb41
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: P30838
is encoded by: hsa:218
name: ALDH3A1
boundary condition: true
has only substance units: false

metaR r0097
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
kinetic law: MODEL1310110005#
name: Acetate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_85b51306_a653_42a9_a7b0_29d5ccb41e60
initial amount: NaN
is encoded by: hsa:594
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
name: BCKDHB
initial concentration: NaN
is: P21953
type: Species

metaM h c
constant: false
name: proton
initial concentration: 1.0
type: Species
is: CHEBI:24636
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
is: C00080

http://identifiers.org/biomodels.db/MODEL1310110005#_d3249830_469f_4b17_8dc7_e91efb250fd7
is encoded by: hsa:29920
is: SBO:0000252
boundary condition: true
is: Q96C36
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PYCR2
type: Species

metaM dgchol x
boundary condition: false
is: SBO:0000247
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: HMDB00637
initial amount: NaN
type: Species
is: CHEBI:36252
constant: false
has only substance units: false
name: glycochenodeoxycholate
initial concentration: 1.0

metaR INSt
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000185
modifier: MODEL1310110005#
name: Inosine transport (diffusion)
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_513a9d0e_828f_40a5_9546_6c336d5c8928
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
name: PPT2
has only substance units: false
type: Species
is encoded by: hsa:9374
boundary condition: true
is: Q9UMR5

http://identifiers.org/biomodels.db/MODEL1310110005#_a2ac26d1_84e2_4450_9b61_395b4eab54db
type: Species
is: P35754
boundary condition: true
initial amount: NaN
name: GLRX
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:2745

http://identifiers.org/biomodels.db/MODEL1310110005#_e61b24e8_8670_4061_b47c_a50abd007b8b
constant: false
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:BG035985
name: _BG035985_1_c
initial amount: NaN
boundary condition: true

metaR PGS
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (5743.1) or (5742.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.14.99.1 Confidence Level: 4 AUTHORS: PMID:14511332,PMID:1907252 NOTES:NJ
is described by: ECO:0000269
type: Reaction
reversible: false
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.14.99.1
modifier: MODEL1310110005#
name: Prostaglandin G/H synthase
fast: false
product: MODEL1310110005#
is: SBO:0000176

metaR MALSO4tm
type: Reaction
reactant: MODEL1310110005#
is described by: ECO:0000269
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
modifier: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
name: Malate:sulfate antiport, mitochondrial
reversible: true
is: SBO:0000185

metaR UMPK7n
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110005#
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110005#
name: UMP kinase (dGTP),nuclear
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110005#_b1191899_90aa_4e9d_a3ce_9129256a5e54
initial concentration: NaN
is: SBO:0000252
is: P00352
initial amount: NaN
constant: false
has only substance units: false
name: ALDH1A1
is encoded by: hsa:216
type: Species
boundary condition: true

metaR GLYOp
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9038835 NOTES:
product: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#
name: glycine oxidase, perixosomal
reactant: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false

metaM 4abut m
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:16865
name: 4-Aminobutanoate
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: C00334
is: HMDB00112
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_4fbb6a06_da02_487f_a902_c53c2698cdd7
name: SUCLG1:SUCLA2
initial amount: NaN
is encoded by: hsa:8803
constant: false
is: SBO:0000297
has only substance units: false
has part: E5KS60
boundary condition: true
type: Species
initial concentration: NaN

metaR DHFtm
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reactant: MODEL1310110005#
name: dihydrofolate reversible mitochondrial transport
reversible: true

metaR r2049
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
product: MODEL1310110005#
modifier: MODEL1310110005#

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaM tyr L e
constant: false
boundary condition: false
is: CHEBI:17895
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: L-tyrosine
type: Species
initial concentration: 1.0
is: HMDB00158

metaR r1378
fast: false
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
is: SBO:0000176
type: Reaction
product: MODEL1310110005#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:

metaM HC00591 c
is: CHEBI:16769
type: Species
initial concentration: 1.0
boundary condition: false
name: 2-oxoglutaramate
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940

http://identifiers.org/biomodels.db/MODEL1310110005#_16db37f3_349f_4629_a3c4_4e5f1b5849d1
initial concentration: NaN
is encoded by: hsa:AI345944
initial amount: NaN
name: _AI345944_1_m
type: Species
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false

metaR r0523
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110005#
reversible: false
is described by: ECO:0000000
product: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
is: SBO:0000176

metaM ppcoa c
is: HMDB01275
is: C00100
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:57392
name: Propanoyl-CoA
boundary condition: false
is: SBO:0000247
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
has only substance units: false
type: Species

metaR RE0577C
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
reversible: true
name: RE0577
product: MODEL1310110005#
modifier: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_59074ff7_1255_4ecb_bcc3_0207bd09fcce
is encoded by: hsa:55191
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: Q6IA69
name: NADSYN1
constant: false
is: SBO:0000252
initial amount: NaN

metaR MALtm
name: malate transport, mitochondrial
fast: false
reversible: true
kinetic law: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
modifier: MODEL1310110005#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110005#_9dbedf2f_434c_438c_a8d9_8c75d248e337
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:5313
is: P30613
type: Species
name: PKLR
boundary condition: true
initial concentration: NaN

metaR r0915
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
kinetic law: MODEL1310110005#
product: MODEL1310110005#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110005#

metaR P5CDm
reversible: false
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Glutamate metabolism EC Number: 1.5.1.12 Confidence Level: 4 AUTHORS: PMID:8621661,PMID:9700195 NOTES:NCD
modifier: MODEL1310110005#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.5.1.12
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
is: SBO:0000176

metaM h e
type: Species
initial concentration: 1.0
name: proton
is: CHEBI:24636
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/3380
is: C00080
constant: false
notes: FORMULA: H CHARGE: 1 INCHI: "

metaR r0522
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
product: MODEL1310110005#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
reversible: false
reactant: MODEL1310110005#
is: SBO:0000176
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10

metaM lpam m
boundary condition: false
is: CHEBI:17460
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
initial amount: NaN
is: SBO:0000247
name: lipoamide
is: HMDB00962

http://identifiers.org/biomodels.db/MODEL1310110005#_ef65a31e_2df9_45fc_bbc2_3e9081ca8518
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is: P13196
boundary condition: true
name: ALAS1
has only substance units: false
is encoded by: hsa:211
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_cf23ba74_18fa_47d4_9228_fbe379e357d4
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:55
initial amount: NaN
boundary condition: true
type: Species
name: ACPP
is: P15309
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_18676699_b486_4d8b_98c7_dbf3c20214fb
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2194
is: P49327
constant: false
initial amount: NaN
name: FASN
type: Species
has only substance units: false
is: SBO:0000252

metaR r0386
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
is: SBO:0000176
product: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
reversible: false
kinetic law: MODEL1310110005#
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4

metaR FAOXC200180m
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110005#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
product: MODEL1310110005#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110005#

metaR It
is described by: ECO:0000269
kinetic law: MODEL1310110005#
name: Iodide uniport
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
fast: false
product: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
is: SBO:0000185
type: Reaction
modifier: MODEL1310110005#

metaR H2Otn
fast: false
product: MODEL1310110005#
name: H2O transport, nuclear
reversible: true
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110005#

metaR r2109
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
fast: false
reversible: true
modifier: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR RE1523M
name: RE1523
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
reactant: MODEL1310110005#

metaR GLYt7 311 r
is: SBO:0000185
reactant: MODEL1310110005#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
is described by: ECO:0000006
reversible: true
modifier: MODEL1310110005#
fast: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction

metaM h2o r
is: C00001
initial amount: NaN
is: CHEBI:15377
constant: false
is: HMDB02111
initial concentration: 1.0
name: H2O
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
type: Species
has only substance units: false
boundary condition: false

metaR r2420
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110005#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is described by: ECO:0000000
reactant: MODEL1310110005#
product: MODEL1310110005#
reversible: true

metaM ppcoa m
initial amount: NaN
constant: false
name: Propanoyl-CoA
is: C00100
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
type: Species
is: HMDB01275
is: CHEBI:57392

http://identifiers.org/biomodels.db/MODEL1310110005#_2a5d0941_b393_4651_9233_f7a5978da597
name: SLC5A9
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:200010
type: Species
is: E9PAK4

metaR ASPDTDe
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.
name: D-aspartate transport, extracellular
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_0b958616_aa08_41f4_8e0b_fa4af8a12374
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AL038231
name: _AL038231_1_c
constant: false
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_8942e63a_6ee6_459a_bb9f_6a5fd77c79bd
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: _206_1_c
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:206

http://identifiers.org/biomodels.db/MODEL1310110005#_1c099c13_e21a_47a4_89c2_20b9bd7611e0
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:9187
constant: false
boundary condition: true
initial concentration: NaN
is: B4DUG1
name: SLC24A1
type: Species
has only substance units: false

metaR GLUDym
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000269
type: Reaction
reversible: true
is: SBO:0000176
name: glutamate dehydrogenase (NADP), mitochondrial
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.4.1.3
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
fast: false
reactant: MODEL1310110005#

metaR RE3624M
reactant: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
is: SBO:0000176
name: RE3624
modifier: MODEL1310110005#
reversible: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaM gchola x
constant: false
initial concentration: 1.0
is: HMDB00138
initial amount: NaN
has only substance units: false
name: glycocholate
is: CHEBI:58235
notes: FORMULA: C26H43NO6 CHARGE: 0 INCHI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
boundary condition: false
type: Species
is: SBO:0000247

metaR H2Otm
type: Reaction
name: H2O transport, mitochondrial
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
is described by: ECO:0000269
product: MODEL1310110005#
is: SBO:0000185
reversible: true
reactant: MODEL1310110005#
modifier: MODEL1310110005#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_8c8c2bf7_a7ff_4282_a71c_137e54146838
boundary condition: true
type: Species
is encoded by: hsa:60481
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
name: ELOVL5
is: F6SH78
has only substance units: false

metaR r0672
is described by: ECO:0000000
reactant: MODEL1310110005#
type: Reaction
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.65
fast: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110005#_51cd1b00_4248_4ee6_ac55_07739222d341
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:AF080579
boundary condition: true
type: Species
is: SBO:0000252
name: _AF080579_1_c
initial concentration: NaN

metaR PROt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
name: L-proline reversible transport via proton symport
product: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
fast: false
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
reversible: true
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110005#_cf9dae33_9c34_4d34_9b4b_fa7258fc9f4e
name: ATP2B3
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:492
type: Species
boundary condition: true
is: Q16720

http://identifiers.org/biomodels.db/MODEL1310110005#_04f9c626_d100_4652_8c9c_62afbe2c2f7f
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:4708
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
name: NDUFB2
is: H7C5B8

metaM pro D e
name: D-proline
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
type: Species
is: CHEBI:16313
initial concentration: 1.0
is: HMDB03411
constant: false
is: SBO:0000247

metaM CE0693 m
is: HMDB11123
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:28387
has only substance units: false
boundary condition: false
constant: false
name: 3-oxolaur-6-cis-enoyl-CoA
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
initial concentration: 1.0

metaR NDP8
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.7.4.9
is described by: ECO:0000269
modifier: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
name: nucleoside-diphosphatase (dUDP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

metaR r2108
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaR LEUKTRB4t
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
type: Reaction
name: leukotriene B4 transport

metaM tdcoa m
boundary condition: false
is: HMDB01521
has only substance units: false
is: CHEBI:57385
is: C02593
initial amount: NaN
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: SBO:0000247
initial concentration: 1.0
name: Tetradecanoyl-CoA (n-C14:0CoA)
constant: false
type: Species

metaR FADH2ETC
name: Complex II reaction for respiratory chain
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110005#
product: MODEL1310110005#
reversible: false
is described by: ECO:0000134
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR H2Otp
fast: false
kinetic law: MODEL1310110005#
name: H2O transport, peroxisomal
reactant: MODEL1310110005#
product: MODEL1310110005#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185

metaR URIK1
modifier: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
name: uridine kinase (ATP:Uridine)
reversible: false
reactant: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.48
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110005#_400e003c_6db5_4d86_b8fb_040288acd4f4
is: O75874
initial amount: NaN
name: IDH1
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:3417
type: Species
has only substance units: false

metaR r0384
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
kinetic law: MODEL1310110005#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110005#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110005#_974eaace_f9d6_4af1_aa8a_43f0558c8404
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:4524
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q59GJ6
name: MTHFR

metaM HC01603 c
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
type: Species
is: SBO:0000247
name: 10-Formyltetrahydrofolate
boundary condition: false
is: C00234
initial amount: NaN
has only substance units: false
constant: false

metaM tdchola e
boundary condition: false
type: Species
initial amount: NaN
constant: false
name: taurochenodeoxycholate
initial concentration: 1.0
is: HMDB00951
is: SBO:0000247
is: CHEBI:9407
has only substance units: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465

http://identifiers.org/biomodels.db/MODEL1310110005#_a9ff6cb0_7e8c_4c64_bb0c_84adcd0c2a26
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ACAA1
is: Q96CA6
boundary condition: true
constant: false
type: Species
is encoded by: hsa:30
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_edda6140_9844_45e8_9858_68371e72a59d
is: P08559
is encoded by: hsa:5160
name: PDHA1
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_8ba5db3a_6938_47ea_8ad2_29075644216d
initial amount: NaN
type: Species
is: Q674R7
initial concentration: NaN
is encoded by: hsa:285973
name: ATG9B
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false

metaR r1749
reactant: MODEL1310110005#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110005#
is: SBO:0000185
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: false
name: Y+LAT2 Utilized transport

metaR NP1
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000304
name: nucleotide phosphatase
reactant: MODEL1310110005#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction

metaR r2107
fast: false
modifier: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#

metaM glu L m
has only substance units: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:29985
is: HMDB00148
constant: false
name: L-glutamate(1-)
type: Species
boundary condition: false

metaM C05957 r
type: Species
constant: false
is: SBO:0000247
is: CHEBI:27485
initial concentration: 1.0
initial amount: NaN
is: HMDB02710
has only substance units: false
name: Prostaglandin J2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
boundary condition: false

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR r0385
reversible: false
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
reactant: MODEL1310110005#
is: SBO:0000176
product: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:

metaM 4ppcys c
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: C04352
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:59458
has only substance units: false
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
initial concentration: 1.0
is: HMDB01117
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_fee07823_b153_42fb_a58e_b7f308d99350
has only substance units: false
name: ENTPD8
boundary condition: true
is: Q5MY95
initial concentration: NaN
type: Species
is encoded by: hsa:377841
initial amount: NaN
is: SBO:0000252
constant: false

metaM CE5236 c
is: CHEBI:28002
is: HMDB03952
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
constant: false
name: O2'-4a-cyclic-tetrahydrobiopterin
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR ALAt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
modifier: MODEL1310110005#
name: L-alanine reversible transport via proton symport
is described by: ECO:0000304
reversible: true
kinetic law: MODEL1310110005#
type: Reaction
fast: false
reactant: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#

metaR PGI
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.1.9
is: SBO:0000176
fast: false
name: glucose-6-phosphate isomerase
reversible: true
reactant: MODEL1310110005#
is described by: ECO:0000134
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:

metaR DCK2n
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.1.74
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
kinetic law: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
name: Deoxycytidine kinase, nuclear (UTP)
fast: false
modifier: MODEL1310110005#
is: SBO:0000176

metaR r1825
name: Y+LAT2 Utilized transport
reactant: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110005#
modifier: MODEL1310110005#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_7b6d3636_0a65_41e1_b3bf_7425763295f6
constant: false
initial amount: NaN
is encoded by: hsa:206358
name: SLC36A1
type: Species
is: Q1LZ56
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_efc3b3fa_9a37_450d_8a0e_8de1e5d0b43c
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:284273
is: Q4G1C4
type: Species
boundary condition: true
constant: false
name: ZADH2
initial amount: NaN
has only substance units: false

metaR PRPNCOAHYDm
kinetic law: MODEL1310110005#
is described by: ECO:0000134
name: Propenoyl-CoA hydrolase (m)
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110005#

metaR ACONTm
type: Reaction
name: Aconitate hydratase
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3
is: SBO:0000176
modifier: MODEL1310110005#
is described by: ECO:0000134

metaR r2106
product: MODEL1310110005#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_d145c7eb_7d78_472b_8176_3469aa24e9ab
type: Species
has only substance units: false
is: F5H2Y9
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8854
initial concentration: NaN
name: ALDH1A2
initial amount: NaN

metaR r0973
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
fast: false
reversible: true
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
name: Facilitated diffusion

metaR NDPK3n
is described by: ECO:0000304
modifier: MODEL1310110005#
fast: false
reversible: true
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reactant: MODEL1310110005#
type: Reaction
is: SBO:0000176
product: MODEL1310110005#

metaR RE1796M
is version of: http://identifiers.org/ec-code/1.1.1.145
product: MODEL1310110005#
type: Reaction
fast: false
is described by: ECO:0000000
name: RE1796
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: true
reactant: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:

metaR RE0344C
reversible: true
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.1.2.2
fast: false
is described by: ECO:0000000
product: MODEL1310110005#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE0344
reactant: MODEL1310110005#

metaR ASCBt4
product: MODEL1310110005#
modifier: MODEL1310110005#
name: L-ascorbate transport via proton symport
fast: false
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
type: Reaction
reversible: true
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaR C204CPT2
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
is: SBO:0000176
reversible: false
product: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
name: arachidonic acid transport into the mitochondria
reactant: MODEL1310110005#

metaR r2323
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110005#_f795eb96_147d_4d90_a144_e3977c3c82b3
is encoded by: hsa:33
is: SBO:0000252
initial amount: NaN
name: ACADL
constant: false
initial concentration: NaN
is: P28330
type: Species
has only substance units: false
boundary condition: true

metaM pail4p hs c
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:58178
has only substance units: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
type: Species

metaR NDPK3m
fast: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reactant: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110005#
is: SBO:0000176
is described by: ECO:0000254
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial

metaR CHOLD2m
reactant: MODEL1310110005#
name: choline dehydrogenase (FAD acceptor), mitochondrial
reversible: false
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
kinetic law: MODEL1310110005#
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.99.1
modifier: MODEL1310110005#
is described by: ECO:0000269
product: MODEL1310110005#

metaM datp c
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
type: Species
name: dATP
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
initial amount: NaN
is: C00131
is: CHEBI:61404
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_e6f96381_dfde_451b_885f_9bcd38ff8931
is encoded by: hsa:AI620219
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: _AI620219_1_c
constant: false

metaR r2322
reversible: true
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM 4abut e
is: CHEBI:3628
constant: false
initial amount: NaN
is: C00334
boundary condition: false
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0
has only substance units: false
name: 4-Aminobutanoate
is: HMDB00112
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_37c16d3e_8c61_4c8f_8afc_8814ac04a1c6
name: NOS3
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is: A0S0A7
has only substance units: false
boundary condition: true
is encoded by: hsa:4846

http://identifiers.org/biomodels.db/MODEL1310110005#_881b8521_782a_479e_8671_43747072c5cb
constant: false
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:277
initial amount: NaN
is: SBO:0000252
name: AMY1B
boundary condition: true
is: P04745

http://identifiers.org/biomodels.db/MODEL1310110005#_a79ab23e_85d3_4653_8b8f_e0d6a4f704ec
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: _AI620219_1_e
is encoded by: hsa:AI620219
type: Species
is: SBO:0000252

metaR PGK
type: Reaction
fast: false
product: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110005#
name: phosphoglycerate kinase
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.2.3
modifier: MODEL1310110005#

metaM h2o x
type: Species
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: H2O
constant: false
is: C00001
is: HMDB02111
is: CHEBI:15377
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaM imp c
is: C00130
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
boundary condition: false
type: Species
is: CHEBI:58053
constant: false
is: HMDB00175
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: IMP
has only substance units: false

metaM HC02208 e
name: prostaglandin-d1
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:27696
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
type: Species
boundary condition: false
is: SBO:0000247

metaR ALR3
fast: false
product: MODEL1310110005#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110005#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
modifier: MODEL1310110005#
name: aldose reductase (acetol)
kinetic law: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.21
is: SBO:0000176

metaR DGCHOLtx
kinetic law: MODEL1310110005#
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110005#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110005#
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaR CMPSASn
type: Reaction
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.7.43
name: CMP sialic acid synthase, nuclear
fast: false
product: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000176
modifier: MODEL1310110005#
reversible: false
is described by: ECO:0000304

metaR r2321
reactant: MODEL1310110005#
reversible: true
type: Reaction
kinetic law: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR PNTOte
product: MODEL1310110005#
reversible: true
fast: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
name: Transport of (R)-Pantothenate
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_091bf564_8f8f_4584_9707_e00b5f58439e
is: SBO:0000252
initial concentration: NaN
type: Species
is: A6H8L5
boundary condition: true
constant: false
initial amount: NaN
name: LIPC
has only substance units: false
is encoded by: hsa:3990

http://identifiers.org/biomodels.db/MODEL1310110005#_d9be154f_7ad4_4602_a73d_49f89dff42aa
constant: false
is: E7EPT3
boundary condition: true
is: SBO:0000252
name: ALDH7A1
initial concentration: NaN
type: Species
is encoded by: hsa:501
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_de1a9e6a_fe00_4a0d_acd6_44313bbd6701
name: TXNRD1
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:7296
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252

metaR ALR2
modifier: MODEL1310110005#
name: aldose reductase (methylglyoxal)
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
reversible: false
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.21

metaR r0670
reactant: MODEL1310110005#
type: Reaction
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
kinetic law: MODEL1310110005#
reversible: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaM pro D c
name: D-proline
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB03411
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:16313
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1

metaM 4abut c
is: SBO:0000247
is: CHEBI:3628
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0
is: C00334
name: 4-Aminobutanoate
type: Species
is: HMDB00112
initial concentration: 1.0

metaR r1538
reversible: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
is described by: ECO:0000000
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
modifier: MODEL1310110005#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_564d251a_30d5_4081_bb8f_0292c3958830
constant: false
is encoded by: hsa:65010
initial amount: NaN
is: Q9NQU1
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SLC26A6
type: Species
initial concentration: NaN

metaM damp c
is: CHEBI:58245
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
initial amount: NaN
type: Species
name: dAMP(2-)
constant: false
is: HMDB00905
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM pa hs m
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
boundary condition: false
name: phosphatidate(2-)
is: CHEBI:57739
initial amount: NaN
is: SBO:0000247

metaM adn e
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial concentration: 1.0
type: Species
is: HMDB00050
name: Adenosine
is: CHEBI:16335
is: C00212
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false

metaR r2320
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110005#
reactant: MODEL1310110005#

metaR r2312
reversible: true
type: Reaction
reactant: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
product: MODEL1310110005#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

http://identifiers.org/biomodels.db/MODEL1310110005#_fe9b113f_aa83_4c92_824d_2d08ca11b590
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000297
name: NME1:NME2
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110005#_41877747_7b9a_4a4c_96ba_6c009422c2b5
initial concentration: NaN
has only substance units: false
name: _AW277253_1_c
boundary condition: true
type: Species
is encoded by: hsa:AW277253
initial amount: NaN
is: SBO:0000252
constant: false

metaR r0974
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
kinetic law: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
name: Active transport
reversible: true
type: Reaction
product: MODEL1310110005#
fast: false
reactant: MODEL1310110005#

metaM 3mgcoa m
constant: false
is: HMDB01057
is: CHEBI:57346
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: trans-3-methylglutaconyl-CoA(5-)
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
initial amount: NaN
type: Species

metaM glyc3p c
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
name: Glycerol 3-phosphate
is: C00093
initial concentration: 1.0
is: CHEBI:57597
is: HMDB00126
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
boundary condition: false

metaM 5mthf e
is: SBO:0000247
is: HMDB01396
initial amount: NaN
type: Species
is: C00440
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
has only substance units: false
name: 5-Methyltetrahydrofolate
is: CHEBI:3729

http://identifiers.org/biomodels.db/MODEL1310110005#_36429a21_3572_4d17_b198_c9440579d0b1
type: Species
initial amount: NaN
name: ACAA2
is encoded by: hsa:10449
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: P42765

metaR INSTt4 2
reversible: true
is described by: ECO:0000006
type: Reaction
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
is: SBO:0000185
name: inositol transport via sodium symport
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
kinetic law: MODEL1310110005#

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_dacd6bcc_4b17_4f37_b375_2ec236d3cf8c
is encoded by: hsa:H77542
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: _H77542_1_r
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_059fa1eb_f65e_43a6_8fb2_fb3a56d04f09
initial amount: NaN
type: Species
is: Q96N66
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:79143
constant: false
name: MBOAT7

http://identifiers.org/biomodels.db/MODEL1310110005#_de6be37b_ef9c_4b17_900f_9f9c25c24204
is: O00337
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:9154
initial concentration: NaN
constant: false
type: Species
name: SLC28A1
initial amount: NaN

metaR r2313
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110005#
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
reactant: MODEL1310110005#

metaM HC01401 m
boundary condition: false
has only substance units: false
constant: false
type: Species
is: CHEBI:27668
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262

metaR LDH D
name: D-lactate dehydrogenase
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.2.4
product: MODEL1310110005#
modifier: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
is described by: ECO:0000304
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_ad8719c5_5867_4976_b099_4abe7060fd5f
has only substance units: false
name: _HG2846_HT2983_1_m
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:HG2846-HT2983
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_562d5316_ff9e_4e5c_aaf7_c032dc60836a
initial amount: NaN
is encoded by: hsa:AI684467
initial concentration: NaN
has only substance units: false
type: Species
name: _AI684467_1_m
is: SBO:0000252
constant: false
boundary condition: true

metaM arachdcoa x
is: HMDB06523
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: arachidonoyl-CoA(4-)

metaR r0443
product: MODEL1310110005#
modifier: MODEL1310110005#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction

metaR r0975
type: Reaction
product: MODEL1310110005#
is: SBO:0000185
name: Facilitated diffusion
reactant: MODEL1310110005#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
kinetic law: MODEL1310110005#
is described by: ECO:0000000
fast: false

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_2fb82829_0f67_488e_81c0_e8b62371a1df
type: Species
is encoded by: hsa:65263
has only substance units: false
initial concentration: NaN
name: PYCRL
constant: false
is: SBO:0000252
is: Q53H96
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_c9ae3076_b391_4f29_9b22_f455d4851110
name: _BF195998_1_x
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:BF195998
constant: false
initial amount: NaN

metaR PROt4 2 r
kinetic law: MODEL1310110005#
is described by: ECO:0000006
product: MODEL1310110005#
type: Reaction
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110005#
reactant: MODEL1310110005#
name: Proline transport (sodium symport) (2:1)

metaM betald m
type: Species
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: CHEBI:15710
initial concentration: 1.0
is: HMDB01252
boundary condition: false
initial amount: NaN
name: betaine aldehyde

metaR r2314
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reactant: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reversible: true

metaM txa2 e
is: HMDB01452
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
name: thromboxane A2(1-)
is: CHEBI:57445
initial amount: NaN
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
initial concentration: 1.0

metaM 5mthf c
has only substance units: false
name: 5-Methyltetrahydrofolate
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:3729
is: C00440
is: HMDB01396
is: SBO:0000247
type: Species
notes: FORMULA: C20H24N7O6 CHARGE: -1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_2336814c_dac5_49b1_93f2_f24541ba8b9a
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: SLC5A10
is encoded by: hsa:125206
boundary condition: true
is: A0PJK1
constant: false
initial amount: NaN
type: Species

metaR RE2677E
product: MODEL1310110005#
name: RE2677
reactant: MODEL1310110005#
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: 2.4.1.47 Confidence Level: 0 AUTHORS: PMID:423891,PMID:9125199 NOTES:IT - fixed proton
kinetic law: MODEL1310110005#
is: SBO:0000176

metaM arachcoa c
name: arachidyl coenzyme A
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: SBO:0000247
type: Species
is: CHEBI:15527
is: HMDB04258
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN

metaR GLNtN1
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
fast: false
reversible: true
modifier: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000185
name: Glutamine transport (Na, H coupled)
is described by: ECO:0000269

metaM CE5117 m
constant: false
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:12947
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117

metaR LACLt
reversible: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMCID: PMC1820816. NOTES:for regeneration of nad in peroxisomes, for providing nad to the beta oxidation
fast: false
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
product: MODEL1310110005#
name: Lactate transport

metaR r0157
is: SBO:0000176
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
is version of: http://identifiers.org/ec-code/6.3.4.2
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
modifier: MODEL1310110005#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is described by: ECO:0000000
product: MODEL1310110005#

metaM malttr e
is: SBO:0000247
name: maltotriose
constant: false
initial amount: NaN
is: CHEBI:27931
is: HMDB01262
initial concentration: 1.0
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
type: Species
is: C01835
has only substance units: false
boundary condition: false

metaR RE2998M
reactant: MODEL1310110005#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110005#
reversible: false
fast: false
name: RE2998
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110005#
type: Reaction

metaR TCHOLAtx
fast: false
product: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
name: bile acid intracellular transport
reversible: true
is: SBO:0000185
type: Reaction

metaR r2315
is described by: ECO:0000000
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_76bebf98_7bfc_46fe_9db7_7d2e29d91bbd
is encoded by: hsa:1962
type: Species
has only substance units: false
is: Q9NY65
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: EHHADH
constant: false

metaR TXA2tr
is: SBO:0000185
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ
name: thromboxane A2 intracellular transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_004a6568_b078_46d0_84bc_2dcb05bc2bdf
is encoded by: hsa:1468
initial amount: NaN
is: Q9UBX3
name: SLC25A10
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_c8dcfb96_4a12_484e_aceb_de585cd0f007
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
name: BAAT
is encoded by: hsa:570
initial concentration: NaN
is: Q14032
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_0b59b28c_643a_4d45_b38d_8c0bef19e381
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:NM 013421
has only substance units: false
initial amount: NaN
name: _NM_013421_1_m
initial concentration: NaN
constant: false

metaR PPAm
is: SBO:0000176
name: inorganic diphosphatase
fast: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.1
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
kinetic law: MODEL1310110005#
product: MODEL1310110005#
modifier: MODEL1310110005#
reactant: MODEL1310110005#
reversible: false

metaR r0156
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is described by: ECO:0000000
product: MODEL1310110005#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110005#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_ade534fb_7c06_4dfe_8d79_0b5b5dffcd1d
constant: false
is encoded by: hsa:6240
is encoded by: hsa:6241
type: Species
initial amount: NaN
has only substance units: false
has part: P31350
name: RRM1:RRM2
initial concentration: NaN
boundary condition: true
has part: P23921
is: SBO:0000297

metaR PROSTGE1t
product: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110005#
is described by: ECO:0000269
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_3d9b4825_7d5b_4fe5_8e25_75f17a5962a0
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1956
is: P00533
boundary condition: true
type: Species
constant: false
name: EGFR

metaR r2316
is: SBO:0000185
type: Reaction
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r0377
modifier: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
product: MODEL1310110005#
kinetic law: MODEL1310110005#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
fast: false

metaM C04849 e
has only substance units: false
type: Species
initial amount: NaN
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
is: CHEBI:57449
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0

metaR VALTA
modifier: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
name: valine transaminase
product: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
type: Reaction
reversible: true
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaM pail4p hs n
initial amount: NaN
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
has only substance units: false
boundary condition: false
is: CHEBI:58178
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
type: Species
initial concentration: 1.0

metaM 5adtststerone c
constant: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:16330
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial concentration: 1.0
has only substance units: false
is: HMDB02961

metaR DNDPt21m
product: MODEL1310110005#
reversible: false
is: SBO:0000185
name: dTDP transport via ADP antiport
modifier: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR PHCHGSm
type: Reaction
product: MODEL1310110005#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
reversible: true
reactant: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
fast: false
is: SBO:0000176

metaR ARACHt
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110005#
is described by: ECO:0000000
name: fatty acid transport via diffusion
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_b4bc3836_f039_48cb_94c1_d73a9ed53a63
name: ACP2
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:53
initial amount: NaN
constant: false
is: E9PCI1

metaM udpglcur c
name: UDP-D-glucuronate
initial amount: NaN
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:58052
boundary condition: false
is: SBO:0000247
is: HMDB00935
is: C00167
type: Species

metaM lald L c
is: HMDB03052
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:18041
type: Species
initial concentration: 1.0
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
name: (S)-lactaldehyde
initial amount: NaN

metaR r1164
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110005#
is: SBO:0000176
type: Reaction
name: EC:2.3.1.26
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_773e41f2_19b6_4ab8_af28_f0f77f916b8d
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: G3XAJ0
constant: false
name: ACAD10
is encoded by: hsa:80724
initial concentration: NaN

metaR r2317
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reactant: MODEL1310110005#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_2d4886c8_0cf0_401f_919f_6dd532383bea
initial amount: NaN
is: SBO:0000252
is: P22413
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:5167
name: ENPP1
constant: false

metaR BHBtm
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
reversible: true

metaM nicrnt c
is: C01185
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
is: HMDB01132
is: CHEBI:57502
type: Species
name: Nicotinate D-ribonucleotide
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM c226coa x
is: http://identifiers.org/pubchem.compound/47205479
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
type: Species
is: C16169
boundary condition: false
name: cervonyl coenzyme A
initial amount: NaN
constant: false

metaR EX 34hpp
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_a8ccbbed_2f58_40d7_bbc0_b64a1ec66a41
is: Q548A7
has only substance units: false
constant: false
is: SBO:0000252
name: SLC26A6
initial amount: NaN
boundary condition: true
is encoded by: hsa:65010
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_4439cb8d_bb43_470b_88f2_662474208d42
initial concentration: NaN
name: SLC7A8
is: SBO:0000252
is encoded by: hsa:23428
is: Q86U05
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false

metaM glyc m
initial amount: NaN
is: SBO:0000247
is: HMDB00131
name: Glycerol
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: C00116
constant: false

metaM urate e
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00289
name: Urate
has only substance units: false
is: CHEBI:17775
initial amount: NaN
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: C00366
is: SBO:0000247

metaM 5adtststerone e
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:16330
is: HMDB02961
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR r2318
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110005#
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110005#_63811db2_cc67_45f7_adab_3bbba4bfdd5a
type: Species
has only substance units: false
is encoded by: hsa:84264
initial concentration: NaN
constant: false
is: SBO:0000252
name: HAGHL
boundary condition: true
initial amount: NaN

metaR FAOXC161802m
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110005#
is described by: ECO:0000269
name: Beta oxidation fatty acid
reversible: false
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#

metaR r0153
is described by: ECO:0000000
name: CTP:pyruvate O2-phosphotransferase EC:2.7.1.40
product: MODEL1310110005#
is: SBO:0000176
modifier: MODEL1310110005#
type: Reaction
reversible: false
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
reactant: MODEL1310110005#

metaM akg m
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
has only substance units: false
name: 2-Oxoglutarate
is: C00026
type: Species
is: CHEBI:16810
initial concentration: 1.0
constant: false
is: HMDB00208
initial amount: NaN
boundary condition: false

metaR URATEt
reversible: false
product: MODEL1310110005#
reactant: MODEL1310110005#
name: urate export from cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110005#
fast: false
type: Reaction

metaM glyc R m
boundary condition: false
name: D-glycerate
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:16659
is: HMDB00139
initial amount: NaN

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR RE2649M
product: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (10965.1) or (11332.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:IT - fixed proton
reactant: MODEL1310110005#
name: RE2649
is version of: http://identifiers.org/ec-code/3.1.2.2
reversible: true
kinetic law: MODEL1310110005#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_2f14e04e_8d00_46b9_9e0b_81f6843c36ce
is: SBO:0000252
name: ALDH1A2
is encoded by: hsa:8854
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: O94788
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_8425a7f5_dc97_4fef_a89b_61df4e0e08a3
has only substance units: false
is encoded by: hsa:224
constant: false
is: SBO:0000252
is: P51648
type: Species
name: ALDH3A2
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR r2319
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reversible: true

metaR RE1525M
type: Reaction
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
name: RE1525
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_3172f5ef_bbb7_41c0_9c20_242ad8c7df74
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species
name: PKLR
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5313
is: P30613

http://identifiers.org/biomodels.db/MODEL1310110005#_9a953f77_86a6_44b0_bbed_e10c64abc4b1
initial amount: NaN
is: SBO:0000252
is: P17174
type: Species
is encoded by: hsa:2805
boundary condition: true
constant: false
name: GOT1
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_1ec41de8_9455_4c91_9d0c_825c36c36ec1
name: TMEM91
is: SBO:0000252
initial concentration: NaN
is: C9JZ62
has only substance units: false
is encoded by: hsa:641649
initial amount: NaN
boundary condition: true
type: Species
constant: false

metaR r0502
modifier: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.113
kinetic law: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110005#
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
reversible: true

metaM ivcoa m
type: Species
name: Isovaleryl-CoA
initial concentration: 1.0
is: CHEBI:57345
has only substance units: false
boundary condition: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB01113

http://identifiers.org/biomodels.db/MODEL1310110005#_7ef0c69e_2c47_4935_ae6e_6e9d1a162dc3
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
is: Q9Y2Q0
initial concentration: NaN
is encoded by: hsa:10396
constant: false
name: ATP8A1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_b839703e_3e96_48ab_8501_c8ba2c1a254e
type: Species
name: SRD5A2
has only substance units: false
initial concentration: NaN
is: P31213
is encoded by: hsa:6716
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaR GSNt
type: Reaction
product: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110005#
modifier: MODEL1310110005#
name: guanosine facilated transport in cytosol

metaR r1611
is: SBO:0000185
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#

metaM c226coa m
name: cervonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205479
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: C16169
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_0a0ce400_effe_4185_891b_35e8b0a31dfa
initial concentration: NaN
type: Species
is encoded by: hsa:AI653169
name: _AI653169_1_c
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM urate c
boundary condition: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
name: Urate
is: CHEBI:17775
constant: false
initial amount: NaN
is: C00366
type: Species
is: HMDB00289
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM glyc c
name: Glycerol
is: SBO:0000247
type: Species
constant: false
is: HMDB00131
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: CHEBI:17754
has only substance units: false
is: C00116
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_83529d26_7e92_480f_9835_0178674196d0
constant: false
is encoded by: hsa:55163
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: PNPO
is: SBO:0000252
is: Q9NVS9
initial concentration: NaN

metaM methf c
boundary condition: false
is: C00445
initial concentration: 1.0
name: 5,10-Methenyltetrahydrofolate
type: Species
is: HMDB01354
has only substance units: false
constant: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial amount: NaN
is: SBO:0000247
is: CHEBI:57455

http://identifiers.org/biomodels.db/MODEL1310110005#_714c4eeb_4701_4596_8b53_6eb4b88a0038
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: ACAA1
initial concentration: NaN
has only substance units: false
is: Q96CA6
is encoded by: hsa:30

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM dadp m
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB01508
constant: false
initial amount: NaN
is: CHEBI:57667
has only substance units: false
name: dADP(3-)

metaM e4hglu m
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
constant: false
name: erythro-4-hydroxy-L-glutamate(1-)
is: CHEBI:6331
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: HMDB02273

metaR HPYRRy
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.1.1.79
name: Hydroxypyruvate reductase (NADPH)
type: Reaction
modifier: MODEL1310110005#
reactant: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#
fast: false

metaR r0596
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
fast: false
modifier: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
reversible: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#

metaR ASPDt6
fast: false
type: Reaction
modifier: MODEL1310110005#
reversible: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
is described by: ECO:0000269
product: MODEL1310110005#
is: SBO:0000185
name: D-aspartate transport via Na, H symport and K antiport
kinetic law: MODEL1310110005#

metaM ach e
initial concentration: 1.0
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: SBO:0000247
type: Species
constant: false
boundary condition: false
name: acetylcholine
initial amount: NaN
has only substance units: false
is: HMDB00895
is: CHEBI:15355

metaM 4abut n
notes: FORMULA: C4H9NO2 CHARGE: 0
is: C00334
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00112
name: 4-Aminobutanoate
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaR LDH L
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
product: MODEL1310110005#
name: L-lactate dehydrogenase
is: SBO:0000176
type: Reaction
reactant: MODEL1310110005#
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.27

http://identifiers.org/biomodels.db/MODEL1310110005#_945504ce_e81f_4444_9637_3a1e57168416
initial concentration: NaN
has only substance units: false
name: SLC25A20
is encoded by: hsa:788
is: O43772
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_b9b390fe_9dc5_4604_af4b_2bad2c3924d3
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI971023
name: _AI971023_1_c
has only substance units: false
initial amount: NaN

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

metaR r1612
reactant: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_7a18915b_3107_489b_9a61_877d8ad6e342
name: ALAS2
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q5JZF5
is: SBO:0000252
constant: false
is encoded by: hsa:212

metaR HISCAT1
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaM CE2435 m
is: CHEBI:57795
type: Species
constant: false
name: trans,cis-deca-2,4-dienoyl-CoA
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_2399d30f_eb57_41ef_a0f2_e630c0d12803
type: Species
name: ALDH7A1
boundary condition: true
constant: false
is: E7EPT3
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:501
has only substance units: false
initial amount: NaN

metaM hco3 e
boundary condition: false
name: Bicarbonate
is: CHEBI:17544
has only substance units: false
constant: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: HMDB00595
is: SBO:0000247
type: Species
is: C00288
initial amount: NaN
initial concentration: 1.0

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM dadp n
is: HMDB01508
name: dADP(3-)
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
constant: false
initial amount: NaN
is: CHEBI:57667
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species

metaM glyc3p m
is: HMDB00126
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
boundary condition: false
is: CHEBI:57597
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: Glycerol 3-phosphate
type: Species
is: SBO:0000247
is: C00093
constant: false

metaR CHSTEROLtrc
reactant: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
name: transport of cholesterol into the cytosol
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000134

metaR r1613
fast: false
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110005#
is: SBO:0000185

metaR BDHm
type: Reaction
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.30
fast: false
modifier: MODEL1310110005#
is: SBO:0000176
product: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110005#_a8c0b951_3c8b_4029_8cb5_82c8a847224d
type: Species
name: PEMT
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:10400
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_88116819_9241_4b5d_9f31_d27ebd532f4a
name: ENO1
boundary condition: true
constant: false
is encoded by: hsa:2023
is: E2DRY6
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM tdchola x
name: taurochenodeoxycholate
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00951
initial concentration: 1.0
is: CHEBI:9407

metaM betald c
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB01252
is: CHEBI:15710
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
name: betaine aldehyde
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species

metaR r0909
reversible: true
fast: false
reactant: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Transport reaction
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_1ee5f075_41ad_48f9_8580_7e4e997aa55c
is encoded by: hsa:1351
name: COX8A
initial amount: NaN
is: Q53XN1
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaR q10h2tc
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110005#
is described by: ECO:0000134
product: MODEL1310110005#
fast: false
name: transport of ubiquinol into cytosol
kinetic law: MODEL1310110005#

metaR PEPCKm
is: SBO:0000176
modifier: MODEL1310110005#
is described by: ECO:0000000
reversible: false
name: Phosphoenolpyruvate carboxykinase (GTP)
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.32
type: Reaction
product: MODEL1310110005#
reactant: MODEL1310110005#

metaM HC01104 e
type: Species
name: 4-nitrophenyl phosphate(2-)
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:61146
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
has only substance units: false

metaR UMPK6
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false
name: UMP kinase (dCTP)
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110005#

metaR r0504
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
reactant: MODEL1310110005#
reversible: true
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
fast: false
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.3.10

http://identifiers.org/biomodels.db/MODEL1310110005#_7449deed_0e96_40ee_b768_32ede4dba4e9
initial concentration: NaN
is: Q99643
is: SBO:0000252
type: Species
name: SDHC
boundary condition: true
is encoded by: hsa:6391
constant: false
has only substance units: false
initial amount: NaN

metaR DCTPtn
is described by: ECO:0000000
name: dCTP diffusion in nucleus
is: SBO:0000185
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
product: MODEL1310110005#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_71144c0a_4df9_4af1_8ba7_16853d205d47
has only substance units: false
initial concentration: NaN
is encoded by: hsa:490
boundary condition: true
is: P20020
name: ATP2B1
is: SBO:0000252
constant: false
initial amount: NaN
type: Species

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM ach c
boundary condition: false
name: acetylcholine
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00895
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
type: Species
constant: false
is: CHEBI:15355
initial amount: NaN

metaR r0594
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_886c9c69_c46c_4d0a_8cfc_c04f5ee6b8df
is encoded by: hsa:222
is: P48448
boundary condition: true
has only substance units: false
constant: false
name: ALDH3B2
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN

metaR r1467
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110005#
name: Postulated transport reaction
product: MODEL1310110005#
reversible: true
fast: false
reactant: MODEL1310110005#
is described by: ECO:0000000
type: Reaction

metaR r0908
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
kinetic law: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
name: Postulated transport reaction
is: SBO:0000185
product: MODEL1310110005#

metaR r1614
type: Reaction
reversible: true
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110005#

metaR GLYSNAT5tc
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_532ce23c_adc0_490c_955c_fe19bea093b0
boundary condition: true
is: Q9ULD0
is encoded by: hsa:55753
type: Species
name: OGDHL
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR UMPK7
reactant: MODEL1310110005#
name: UMP kinase (dGTP)
modifier: MODEL1310110005#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
kinetic law: MODEL1310110005#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_0a090fdb_bb8a_4f73_8b77_3f2432d469e3
initial amount: NaN
is encoded by: hsa:197257
type: Species
initial concentration: NaN
is: SBO:0000252
name: LDHD
has only substance units: false
boundary condition: true
constant: false

metaR NH4t3r
is: SBO:0000185
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
reversible: true
reactant: MODEL1310110005#
name: ammonia transport via proton antiport
type: Reaction
fast: false
modifier: MODEL1310110005#
is described by: ECO:0000269
kinetic law: MODEL1310110005#

metaR SUCD1m
fast: false
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
name: succinate dehydrogenase
product: MODEL1310110005#
modifier: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.5.1

metaR r0224
is: SBO:0000176
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
fast: false
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
product: MODEL1310110005#
modifier: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaR CYTDK2m
reactant: MODEL1310110005#
name: cytidine kinase (ATP), mitochondrial
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT

metaR CYTDt4
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000269
modifier: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (9154.1) or (9154.2) or (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
fast: false
kinetic law: MODEL1310110005#
reversible: false
name: cytidine transport in via sodium symport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_89ac666c_66ef_444e_9ef4_6295fd3c0eba
has only substance units: false
is: SBO:0000252
is encoded by: hsa:123041
is: Q8NFF2
type: Species
initial amount: NaN
constant: false
name: SLC24A4
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_16a099a2_c395_49b1_9e0e_a541bda701c2
initial concentration: NaN
name: COX3
initial amount: NaN
is: SBO:0000252
type: Species
is: P00414
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:4514

metaR UMPK4
modifier: MODEL1310110005#
name: UMP kinase (GTP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_e9869140_92fe_4919_93da_6ab9f53fa66c
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
name: SLC34A1
is: Q7Z725
constant: false
is encoded by: hsa:6569
boundary condition: true
initial concentration: NaN

metaR RE1534M
reactant: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is: SBO:0000176
type: Reaction
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110005#
name: RE1534
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_21cf9b28_9e6a_48f1_aa61_dfceb20c678b
boundary condition: true
is: SBO:0000252
name: ACOX3
has only substance units: false
is: O15254
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:8310
initial concentration: NaN

metaM txa2 r
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
constant: false
boundary condition: false
name: thromboxane A2(1-)
initial concentration: 1.0
is: HMDB01452
is: CHEBI:57445
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN

metaM leuktrF4 e
name: leukotriene F4
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: CHEBI:27491
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
is: HMDB06465
is: SBO:0000247
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_550a21d5_80de_4c44_ab45_5c5f358d6f31
name: UPP2
is: O95045
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:151531

http://identifiers.org/biomodels.db/MODEL1310110005#_5bc69024_57ed_45ae_836e_3fe5f90b3494
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:6511
initial concentration: NaN
is: P48664
name: SLC1A6

metaR r1975
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110005#
product: MODEL1310110005#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110005#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110005#_3e639cd1_e3fb_4942_8d8b_981aad78e471
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P00918
is encoded by: hsa:760
type: Species
name: CA2
boundary condition: true

metaR UMPK5
type: Reaction
modifier: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110005#
name: UMP kinase (dATP)
reversible: true
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is described by: ECO:0000269
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_07efd730_cc1d_4898_b1cf_ce08538a1971
is: SBO:0000252
type: Species
is: Q92536
is encoded by: hsa:9057
name: SLC7A6
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

metaR r1051
kinetic law: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
type: Reaction
product: MODEL1310110005#
name: Vesicular transport
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110005#

metaM CE5236 n
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB03952
is: CHEBI:28002
name: O2'-4a-cyclic-tetrahydrobiopterin
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236

http://identifiers.org/biomodels.db/MODEL1310110005#_10d98ae4_5c84_4c65_ad9e_f5c1b50b2e3d
initial amount: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:220
initial concentration: NaN
is: P47895
has only substance units: false
name: ALDH1A3
is: SBO:0000252

metaR SO4t4 2
product: MODEL1310110005#
reversible: true
type: Reaction
reactant: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
fast: false
modifier: MODEL1310110005#
name: sulfate transport via sodium symport
is described by: ECO:0000269
kinetic law: MODEL1310110005#

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_28f058db_8d7d_4a73_bae5_610d48510c04
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: O14521
name: SDHD
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6392
constant: false

metaR r0226
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
kinetic law: MODEL1310110005#
type: Reaction
reversible: false
fast: false
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000176
modifier: MODEL1310110005#
is described by: ECO:0000000

metaR RE2649C
is described by: ECO:0000000
kinetic law: MODEL1310110005#
product: MODEL1310110005#
name: RE2649
is version of: http://identifiers.org/ec-code/3.1.2.2
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_f89522c9_6556_4e57_96a0_4c4e0c76a5a0
boundary condition: true
has only substance units: false
constant: false
name: ADH4
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:127
is: P08319
initial amount: NaN

metaM 3pg c
is: CHEBI:58272
is: SBO:0000247
is: C00197
is: HMDB00807
is: http://identifiers.org/pubchem.compound/3497
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: 3-Phospho-D-glycerate

http://identifiers.org/biomodels.db/MODEL1310110005#_02c456a5_b636_4b99_9595_8ebf6452f443
is encoded by: hsa:23169
initial amount: NaN
constant: false
name: SLC35D1
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is: Q9NTN3

http://identifiers.org/biomodels.db/MODEL1310110005#_205a6313_e5a2_4786_9f74_357cc7271e92
type: Species
initial amount: NaN
name: ENTPD1
initial concentration: NaN
boundary condition: true
is: Q86VV3
has only substance units: false
is encoded by: hsa:953
is: SBO:0000252
constant: false

metaR r0730
modifier: MODEL1310110005#
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110005#
reversible: false
is described by: ECO:0000000
fast: false

metaR CREATt4 2 r
fast: false
product: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
name: Creatine transport (sodium symport) (2:1)
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110005#

metaR PGPPT
product: MODEL1310110005#
reactant: MODEL1310110005#
name: phosphatidyl-CMP: glycerophosphate phosphatidyltransferase
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/2.7.8.5
notes: GENE_ASSOCIATION: (9489.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 2 AUTHORS: PMID:10799718 NOTES:NJ
type: Reaction
modifier: MODEL1310110005#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_ab92d3b5_905e_4f6d_a95c_a4114bc2e9c3
initial amount: NaN
is: P49247
boundary condition: true
type: Species
is encoded by: hsa:22934
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
name: RPIA

metaR GUAt
product: MODEL1310110005#
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000269
name: Guanine transport
fast: false
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR

metaM glyc e
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
name: Glycerol
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:17754
is: HMDB00131
is: C00116
type: Species
initial concentration: 1.0
has only substance units: false

metaR RE2269E
reactant: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.21.39
kinetic law: MODEL1310110005#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
product: MODEL1310110005#
fast: false
name: RE2269
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:

metaR UMPK2
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (CTP)
modifier: MODEL1310110005#
reversible: true
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_cc344524_6c41_491d_9ee9_6fa0f08610eb
is: SBO:0000252
initial amount: NaN
constant: false
is: E7EQF2
initial concentration: NaN
boundary condition: true
type: Species
name: CROT
is encoded by: hsa:54677
has only substance units: false

metaR r1610
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
is: SBO:0000185

metaM bhb m
is: CHEBI:10983
initial concentration: 1.0
initial amount: NaN
name: (R)-3-hydroxybutyrate
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011
boundary condition: false
type: Species

metaR HYXNt
is described by: ECO:0000269
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is: SBO:0000185
type: Reaction
name: Hypoxanthine transport
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
reversible: true
reactant: MODEL1310110005#
product: MODEL1310110005#

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_55c1caee_8492_4dee_9149_5bf664c4c701
name: ADSSL1
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:122622
is: SBO:0000252
is: Q8N142
boundary condition: true
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_942028a8_4d2b_42e9_9ef0_0cb9daafed55
constant: false
is: Q02338
name: BDH1
is encoded by: hsa:622
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_707de7e4_140e_4a2f_a86b_26c67685424a
boundary condition: true
is: SBO:0000252
constant: false
name: BCKDHB
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:594
is: P21953
initial concentration: NaN

metaM leuktrF4 c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
constant: false
name: leukotriene F4
initial concentration: 1.0
is: CHEBI:27491
has only substance units: false
type: Species
boundary condition: false
is: HMDB06465

metaR r0731
reversible: false
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
product: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:

metaR r0509
product: MODEL1310110005#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110005#
is: SBO:0000176
reactant: MODEL1310110005#
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_dd80d5b2_6109_4aab_a52d_60a8e2bef9fe
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: ENPP3
constant: false
is encoded by: hsa:5169
boundary condition: true
type: Species
is: Q308M7
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_d4b58030_8d17_429c_b41b_ed98a4d9bc99
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: Q14117
name: DPYS
initial amount: NaN
type: Species
is encoded by: hsa:1807
is: SBO:0000252

metaR ADAe
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.5.4.4
is: SBO:0000176
fast: false
reactant: MODEL1310110005#
name: Adenosine deaminase, extracellular
is described by: ECO:0000269
modifier: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
type: Reaction
reversible: false

metaM hco3 c
type: Species
is: C00288
has only substance units: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: CHEBI:17544
is: HMDB00595
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: Bicarbonate

metaR CYTDt5le
name: cytidine transport (1:2 Na/cytd cotransport)
reversible: false
product: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
modifier: MODEL1310110005#
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
fast: false

metaM trdox c
name: Oxidized thioredoxin
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
is: C00343
is: CHEBI:18191
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_d0dff99b_0331_4ab2_8f38_b2573dfd52aa
is: P43166
initial amount: NaN
name: CA7
type: Species
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:766
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_6353a5d3_25b2_47e2_bba2_ee95d81709e5
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110005#_fb7e712e_e794_4cea_bd77_14d9ccb30272
type: Species
is: P49902
initial amount: NaN
is encoded by: hsa:22978
is: SBO:0000252
name: NT5C2
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaR UMPK3
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110005#
reactant: MODEL1310110005#
name: UMP kinase (UTP)
reversible: true
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_900944bd_ad0d_4d24_b8c1_b49272e7a2f9
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:6319
boundary condition: true
is: O00767
initial amount: NaN
constant: false
is: SBO:0000252
name: SCD

metaR LPS3e
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.23 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:NJ
reversible: false
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.1.1.3
name: lipase, extracellular
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110005#
is described by: ECO:0000000
modifier: MODEL1310110005#

metaR O2tm
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
type: Reaction
fast: false
reactant: MODEL1310110005#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110005#
name: O2 transport (diffusion)

metaM gdp m
type: Species
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP
is: CHEBI:58189
boundary condition: false
initial concentration: 1.0
is: C00035
is: SBO:0000247
is: HMDB01201

metaR r1608
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#

metaM 44mzym r
is: CHEBI:18364
initial amount: NaN
name: 14-demethyllanosterol
type: Species
constant: false
is: HMDB01286
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_9f9c40b9_b8f9_4edc_89cd_0c5ae5c933c7
is encoded by: hsa:AA203143
initial concentration: NaN
constant: false
name: _AA203143_1_c
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN

metaR r2200
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110005#
product: MODEL1310110005#
fast: false
type: Reaction
reactant: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
modifier: MODEL1310110005#
is: SBO:0000185

metaR r0669
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_2ed3ba67_e9fe_43bb_9713_209bee072a75
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
name: SLC3A2
is encoded by: hsa:6520
is: P08195
initial concentration: NaN

metaM HC01231 c
boundary condition: false
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
name: N-[(R)-pantothenoyl]-L-cysteinate
initial concentration: 1.0
is: CHEBI:58480

metaM ach n
is: CHEBI:15355
type: Species
name: acetylcholine
is: HMDB00895
is: SBO:0000247
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false

metaR FRDPtr
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110005#
reversible: true
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
product: MODEL1310110005#
name: lipid, flip-flop intracellular transport
type: Reaction
fast: false

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaR PPCOAOm
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
type: Reaction
modifier: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000269
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
reversible: false
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
kinetic law: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_946f514e_ea3d_4871_a023_250f5b6f49f2
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is: Q5FWF5
boundary condition: true
initial concentration: NaN
name: ESCO1
is encoded by: hsa:114799

http://identifiers.org/biomodels.db/MODEL1310110005#_4e5e2d1b_293e_4101_a9ed_bfb159a59bd4
name: SLC6A4
is encoded by: hsa:6532
initial amount: NaN
boundary condition: true
is: P31645
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
constant: false

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_c738fff8_b099_473b_9831_b6006b4a9b6d
is: P00374
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
name: DHFR
initial concentration: NaN
is encoded by: hsa:1719
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_5eb0e559_b371_4551_bf43_4ebffef57dab
constant: false
is encoded by: hsa:6568
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q14916
boundary condition: true
initial amount: NaN
type: Species
name: SLC17A1

metaM phe L c
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00159
boundary condition: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: CHEBI:17295
initial concentration: 1.0
constant: false
name: L-phenylalanine

metaR MTHFD
reversible: true
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
fast: false
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NADP)
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.5.1.5

http://identifiers.org/biomodels.db/MODEL1310110005#_6f807b09_6f40_4652_b2c1_d59ba5304cba
is encoded by: hsa:3417
name: IDH1
type: Species
initial amount: NaN
is: O75874
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false

metaM glu5sa m
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: CHEBI:17232
has only substance units: false
is: C01165
is: SBO:0000247
boundary condition: false
is: HMDB02104
name: L-Glutamate 5-semialdehyde
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_88d1fc49_a767_4473_b055_0bf6ab95785c
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:219
type: Species
name: ALDH1B1
has only substance units: false
is: P30837
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_4342dd0e_e6bd_4ec6_971b_0b5da28b40f9
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8879
type: Species
initial amount: NaN
name: SGPL1
is: O95470
constant: false
initial concentration: NaN
has only substance units: false

metaM CE5118 m
boundary condition: false
is: CHEBI:12947
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
initial amount: NaN

metaR r1607
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
reactant: MODEL1310110005#

metaM gdp n
is: HMDB01201
has only substance units: false
is: SBO:0000247
name: GDP(3-)
type: Species
initial amount: NaN
is: CHEBI:58189
boundary condition: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0
constant: false

metaM hxan e
type: Species
constant: false
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
initial amount: NaN
name: hypoxanthine
is: SBO:0000247
is: CHEBI:17368
is: HMDB00157
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM arg L m
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
name: L-argininium(1+)
boundary condition: false
is: SBO:0000247
is: HMDB00517
is: CHEBI:32682
constant: false

metaR RE3566C
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#
is: SBO:0000176
name: RE3566
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_985a42fd_fbec_4a93_bede_f121306845f6
is: SBO:0000252
type: Species
has only substance units: false
is: O95436
name: SLC34A2
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:10568

metaM no e
is: CHEBI:16480
is: HMDB03378
constant: false
boundary condition: false
is: C00533
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: SBO:0000247
name: Nitric oxide
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_5a2b219e_0dce_43c8_bfc9_774c1a39bb1a
constant: false
is: D9HTE9
initial amount: NaN
name: SLC25A1
is encoded by: hsa:6576
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR ACCOAC
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaR r0083
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.42
modifier: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
type: Reaction
reversible: true
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

metaM dhap x
name: Dihydroxyacetone phosphate
is: C00111
has only substance units: false
is: SBO:0000247
is: HMDB01473
initial concentration: 1.0
boundary condition: false
is: CHEBI:57642
constant: false
is: http://identifiers.org/pubchem.compound/3411
initial amount: NaN
type: Species

metaR r0720
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110005#
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110005#

metaM akg c
constant: false
boundary condition: false
name: 2-Oxoglutarate
is: C00026
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
initial concentration: 1.0
has only substance units: false
is: CHEBI:16810
initial amount: NaN
is: HMDB00208
is: SBO:0000247
type: Species

metaM mlthf m
is: HMDB01533
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15636
constant: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
has only substance units: false
boundary condition: false
is: C00143
type: Species
name: 5,10-Methylenetetrahydrofolate
initial amount: NaN

metaM acgam c
is: HMDB00215
type: Species
name: N-acetyl-D-glucosamine
is: CHEBI:17411
has only substance units: false
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR r0002
kinetic law: MODEL1310110005#
is: SBO:0000185
type: Reaction
reversible: true
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
reactant: MODEL1310110005#

metaR UMPK6n
name: UMP kinase (dCTP),nuclear
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
modifier: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
is: SBO:0000176
reversible: true

metaR r2202
reversible: true
modifier: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

metaR r1384
fast: false
is: SBO:0000176
name: Guanosine aminohydrolase EC:3.5.4.15
kinetic law: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
product: MODEL1310110005#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110005#

metaR PCHOLPm hs
name: choline phosphatase
product: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
reactant: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.4
is: SBO:0000176
kinetic law: MODEL1310110005#
is described by: ECO:0000269
reversible: false

metaR GTHPe
product: MODEL1310110005#
reversible: true
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.11.1.9
type: Reaction
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (2878.1) or (257202.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:3619451 NOTES:SAB
name: glutathione peroxidase (e)
is described by: ECO:0000269
fast: false
is: SBO:0000176
kinetic law: MODEL1310110005#

metaR HACD1m
type: Reaction
fast: false
reactant: MODEL1310110005#
is described by: ECO:0000134
reversible: true
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110005#
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is: SBO:0000176
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological

metaM phe L e
name: L-phenylalanine
is: HMDB00159
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
type: Species
is: CHEBI:17295

metaM 5adtststerone r
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:16330
has only substance units: false
is: HMDB02961
is: SBO:0000247
initial amount: NaN
name: 17beta-hydroxy-5alpha-androstan-3-one
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917

http://identifiers.org/biomodels.db/MODEL1310110005#_e79345d9_7bde_4010_9a41_7c16b4320df4
is: SBO:0000252
is: Q6YFQ2
initial amount: NaN
boundary condition: true
name: COX6B2
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:125965

metaR DUMPtn
is: SBO:0000185
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: dUMP nuclear transport
reactant: MODEL1310110005#

metaM dadp c
name: dADP
constant: false
is: SBO:0000247
is: C00206
is: HMDB01508
is: CHEBI:57667
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
has only substance units: false
initial amount: NaN

metaR r0082
modifier: MODEL1310110005#
fast: false
type: Reaction
reversible: true
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
reactant: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000176
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.6.1.2

metaR SERtN1
reactant: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
name: Serine transport (Na, H coupled)
product: MODEL1310110005#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110005#
fast: false
is: SBO:0000185
type: Reaction

metaR r1685
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false
reversible: false
is: SBO:0000185
modifier: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_d338a758_dcf9_4f9d_869a_04608aec1d62
type: Species
is: SBO:0000252
name: RPE
initial concentration: NaN
initial amount: NaN
is: Q53TV9
constant: false
is encoded by: hsa:6120
boundary condition: true
has only substance units: false

metaR 5ADTSTSTERONEte
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
fast: false
name: 5 alpha dihydrotesterone transport
type: Reaction
kinetic law: MODEL1310110005#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

http://identifiers.org/biomodels.db/MODEL1310110005#_512452cd_9b86_4bb9_a678_51c9654fbd03
has only substance units: false
initial concentration: NaN
is: E2QC23
is: SBO:0000252
name: GCAT
type: Species
is encoded by: hsa:23464
initial amount: NaN
constant: false
boundary condition: true

metaR r2201
product: MODEL1310110005#
kinetic law: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
is: SBO:0000185
modifier: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_f98a10bc_5e5e_484f_a3a2_95f89f4090c7
is: P09669
initial amount: NaN
constant: false
boundary condition: true
name: COX6C
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1345
type: Species

metaR FAEL205
name: fatty-acyl-CoA elongation (n-C20:5CoA)
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reactant: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
is described by: ECO:0000000
product: MODEL1310110005#
kinetic law: MODEL1310110005#

metaM CE4876 r
initial concentration: 1.0
constant: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
is: CHEBI:12947
is: SBO:0000247
name: delta12-Prostaglandin J2
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false

metaR r1609
product: MODEL1310110005#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110005#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR O2tn
reversible: true
name: O2 nuclear transport
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#

metaM no c
name: Nitric oxide
is: C00533
is: SBO:0000247
type: Species
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
boundary condition: false
initial concentration: 1.0
is: CHEBI:16480
is: HMDB03378
initial amount: NaN
constant: false
has only substance units: false

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaR r0668
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
product: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.19
type: Reaction
is: SBO:0000176
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
reversible: true
is described by: ECO:0000000

metaR r0722
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/4.2.3.12
is described by: ECO:0000000
fast: false
reactant: MODEL1310110005#
modifier: MODEL1310110005#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: true
type: Reaction

metaR r0081
product: MODEL1310110005#
type: Reaction
modifier: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.12
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2

http://identifiers.org/biomodels.db/MODEL1310110005#_b402e8b2_2d0f_4f32_8475_8ea1bfca2a36
is encoded by: hsa:1119
initial concentration: NaN
name: CHKA
is: SBO:0000252
initial amount: NaN
constant: false
is: P35790
has only substance units: false
boundary condition: true
type: Species

metaM hxan c
has only substance units: false
name: Hypoxanthine
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00157
boundary condition: false
is: C00262
type: Species
constant: false
is: CHEBI:17368

metaR PSDm hs
is described by: ECO:0000269
fast: false
is: SBO:0000176
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
name: Phosphatidylserine decarboxylase
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
reactant: MODEL1310110005#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.65
product: MODEL1310110005#

metaR UMPK
modifier: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
is described by: ECO:0000269
is: SBO:0000176
name: UMP kinase
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110005#
reversible: true

metaR r1540
is: SBO:0000185
kinetic law: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
type: Reaction
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is described by: ECO:0000000
product: MODEL1310110005#
reversible: false

metaM frdp r
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
initial amount: NaN
constant: false
initial concentration: 1.0
is: C00448
type: Species
boundary condition: false
is: CHEBI:175763
is: HMDB00961
name: Farnesyl diphosphate
has only substance units: false
is: SBO:0000247

metaR LAPCOAl
fast: false
reversible: false
notes: GENE_ASSOCIATION: (53.1) SUBSYSTEM: CoA catabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:11923312,PMID:11994049 NOTES:IT. human enzymes overexpressed on E.coli, Pig Liver
reactant: MODEL1310110005#
name: lysosomal acid phosphorylase (CoA)
kinetic law: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/3.1.3.2
is: SBO:0000176

metaR TCHOLAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
product: MODEL1310110005#
type: Reaction
name: bile acid intracellular transport

metaM cdpdag hs m
has only substance units: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
name: CDP-diacylglycerol(2-)
is: CHEBI:58332
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species

metaM arachdcoa c
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: CHEBI:57368
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB06523
type: Species
name: arachidonoyl-CoA(4-)
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_21c5733e_6460_4af5_b75a_787f154e1ffe
has only substance units: false
is: P27708
type: Species
name: CAD
is encoded by: hsa:790
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR r1604
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_1c85f62f_3502_4554_9cdd_85e1d42376fe
initial amount: NaN
is: P51648
initial concentration: NaN
constant: false
name: ALDH3A2
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:224

metaR CYSO
is version of: http://identifiers.org/ec-code/1.13.11.20
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
modifier: MODEL1310110005#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: false
fast: false
product: MODEL1310110005#
name: cysteine oxidase

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaM bhb c
name: (R)-3-hydroxybutyrate
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011

http://identifiers.org/biomodels.db/MODEL1310110005#_6de45b1a_aff8_4ffd_be8c_4b3a7bd77148
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is: Q5TDP6
name: LGSN
is encoded by: hsa:51557
has only substance units: false

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaM CE2432 m
has only substance units: false
constant: false
type: Species
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:57795
initial amount: NaN

metaR PNP
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14704851,PMID:9030766 NOTES:IT
is described by: ECO:0000269
type: Reaction
reversible: true
reactant: MODEL1310110005#
is: SBO:0000176
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
name: purine-nucleoside phosphorylase
is version of: http://identifiers.org/ec-code/2.4.2.1

http://identifiers.org/biomodels.db/MODEL1310110005#_6624780a_6b25_475b_a171_d92ca433864a
boundary condition: true
name: GPD1
has only substance units: false
is: F8W1L5
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:2819

metaR r0724
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: true
is: SBO:0000176
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.1.33
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
modifier: MODEL1310110005#
fast: false

metaM cmpacna n
name: CMP-N-acetyl-beta-neuraminate(2-)
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:57812
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_3856e10a_42ec_4c5b_bff1_dd58e3cbc0ca
name: SLCO2A1
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6578
constant: false
is: Q92959
type: Species
initial amount: NaN
has only substance units: false

metaM 2mbcoa m
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57336
name: 2-methylbutanoyl-CoA(4-)
has only substance units: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
is: HMDB01041
initial concentration: 1.0
type: Species
initial amount: NaN

metaR r1603
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_81d37561_e960_4cb3_8995_aea0a8787f2b
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:6718
is: P51857
type: Species
is: SBO:0000252
name: AKR1D1
has only substance units: false

metaR RPI
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
modifier: MODEL1310110005#
name: ribose-5-phosphate isomerase
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/5.3.1.6
kinetic law: MODEL1310110005#
product: MODEL1310110005#
type: Reaction

metaM udpglcur r
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00935
constant: false
is: CHEBI:58052
name: UDP-D-glucuronate
is: C00167
type: Species
initial concentration: 1.0
boundary condition: false

metaR CBR2
is version of: http://identifiers.org/ec-code/1.1.1.189
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
reversible: false
is described by: ECO:0000269
product: MODEL1310110005#
name: Carbonyl reductase [NADPH] 1
kinetic law: MODEL1310110005#
fast: false
type: Reaction
modifier: MODEL1310110005#
is: SBO:0000176
reactant: MODEL1310110005#

metaM frdp x
has only substance units: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
constant: false
is: SBO:0000247
is: HMDB00961
boundary condition: false
is: CHEBI:175763
type: Species
initial concentration: 1.0
initial amount: NaN
name: farnesyl pyrophosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110005#_99bf7054_7a41_4690_ae64_c71b38a59532
name: MTHFD1
is encoded by: hsa:4522
is: P11586
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_b1fd3ad0_e992_4438_b08f_837f53041e77
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q6NSB3
is encoded by: hsa:276
initial amount: NaN
type: Species
name: AMY1A
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_88c0a51a_f86c_4269_b42a_c5b39c07abf6
type: Species
constant: false
name: SLC22A1
is: O15245
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6580

metaM 34dhpha c
is: CHEBI:17612
is: HMDB01336
initial concentration: 1.0
name: (3,4-dihydroxyphenyl)acetate
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
is: SBO:0000247

metaM gtp c
initial amount: NaN
constant: false
is: C00044
name: GTP
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: CHEBI:37565
initial concentration: 1.0
has only substance units: false
is: HMDB01273
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_b1ce4705_2e58_450e_a6a2_89b8835ddce4
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6505
initial amount: NaN
type: Species
is: SBO:0000252
is: P43005
has only substance units: false
name: SLC1A1

metaM 3pg m
is: SBO:0000247
initial concentration: 1.0
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
type: Species
is: HMDB00807
boundary condition: false
is: CHEBI:58272
has only substance units: false
constant: false
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
initial amount: NaN

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaM HC01403 m
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:28325
initial concentration: 1.0
initial amount: NaN
constant: false
name: (S)-Hydroxydecanoyl-CoA
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
has only substance units: false

metaR DINt
kinetic law: MODEL1310110005#
reversible: true
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
name: deoxyinosine transport via diffusion
type: Reaction
reactant: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_ee34be88_162e_420e_8f67_31136e339957
has only substance units: false
constant: false
name: _AI373818_1_m
is encoded by: hsa:AI373818
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR r1606
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM pyr c
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1
initial concentration: 1.0
is: HMDB00243
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: C00022
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate
is: CHEBI:15361

metaR BILIRUBtr
reversible: true
reactant: MODEL1310110005#
is: SBO:0000185
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
is described by: ECO:0000000

metaM dmnoncrn m
name: 4,8 dimethylnonanoyl carnitine
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB06202

http://identifiers.org/biomodels.db/MODEL1310110005#_c694478f_c732_40f8_b6ec_5a1fca0543f1
type: Species
is encoded by: hsa:AV713053
boundary condition: true
initial amount: NaN
constant: false
name: _AV713053_1_m
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR RPE
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
is: SBO:0000176
reversible: true
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.1.3.1
name: ribulose 5-phosphate 3-epimerase
type: Reaction

metaR r0590
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
reactant: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
kinetic law: MODEL1310110005#
reversible: false
modifier: MODEL1310110005#
fast: false

metaM dhdascb c
boundary condition: false
is: SBO:0000247
name: dehydroascorbide(1-)
initial amount: NaN
type: Species
is: CHEBI:58070
initial concentration: 1.0
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
has only substance units: false
constant: false
is: HMDB01264

metaR r0086
type: Reaction
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
product: MODEL1310110005#
fast: false
reversible: false
reactant: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is: SBO:0000176
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.5.1.3

metaM HC01118 r
initial concentration: 1.0
constant: false
name: presqualene diphosphate(3-)
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
type: Species
is: CHEBI:57310
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_0243045d_d65e_4a54_ba60_d4edb9a08ec8
has only substance units: false
initial amount: NaN
type: Species
name: RDH14
is: SBO:0000252
boundary condition: true
is: Q9HBH5
is encoded by: hsa:57665
initial concentration: NaN
constant: false

metaM 3otdcoa m
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
is: CHEBI:28726
type: Species
initial concentration: 1.0
has only substance units: false
name: 3-Oxotetradecanoyl-CoA
is: HMDB03935

metaM bhb e
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247
name: (R)-3-hydroxybutyrate
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:10983
is: HMDB00011

metaR KHK
reversible: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.3 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.3
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110005#
modifier: MODEL1310110005#
name: ketohexokinase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_8ce6805f_1d80_477a_8a04_a92b49e03b56
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: RDH16
type: Species
has only substance units: false
is encoded by: hsa:8608
is: O75452
constant: false

metaR r0726
modifier: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
product: MODEL1310110005#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.33
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
kinetic law: MODEL1310110005#
type: Reaction
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110005#_a73210dd_271b_49f0_97c5_41ed80f1e14a
initial amount: NaN
is: SBO:0000252
name: TBXAS1
boundary condition: true
is: Q53F23
type: Species
constant: false
is encoded by: hsa:6916
initial concentration: NaN
has only substance units: false

metaR r1605
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110005#
is: SBO:0000185

metaR r1544
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110005#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_09fa3b41_9324_423f_9103_ff2e67ff1d41
initial concentration: NaN
type: Species
name: PPA2
is encoded by: hsa:27068
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true

metaM pyr e
is: CHEBI:15361
initial concentration: 1.0
constant: false
is: HMDB00243
type: Species
has only substance units: false
initial amount: NaN
name: pyruvate
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022

metaM xu1p D c
is: HMDB06534
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h3,5-7,9H,1-2H2,(H2,10,11,12)/t3-,5-/m1/s1
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
type: Species
name: D-Xylulose 1-phosphate
initial concentration: 1.0
initial amount: NaN

metaR r1464
product: MODEL1310110005#
reactant: MODEL1310110005#
name: Active transport
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_011703b5_9bc5_43ea_a018_457f173a2597
name: DYLX2
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:9856
is: F5H123
constant: false
initial amount: NaN
initial concentration: NaN

metaR r0591
is described by: ECO:0000000
reactant: MODEL1310110005#
is: SBO:0000176
modifier: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
type: Reaction

metaR r0085
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
reactant: MODEL1310110005#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
product: MODEL1310110005#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_6772ea3d_9a58_487a_b026_faf5c4b9e552
initial amount: NaN
is encoded by: hsa:6539
constant: false
is: SBO:0000252
name: SLC6A12
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: P48065

http://identifiers.org/biomodels.db/MODEL1310110005#_9cb77a00_024d_4b27_b2ea_41b87e91b3a8
initial amount: NaN
has only substance units: false
constant: false
is: O95674
type: Species
boundary condition: true
name: CDS2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8760

metaR O2Stx
name: superoxide anion transport via diffusion (peroxisome)
kinetic law: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110005#
reversible: true

metaR r0512
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
reactant: MODEL1310110005#
reversible: true
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
fast: false
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_c5a7d7cb_e7c3_4a8b_a7c2_37519b5eab03
constant: false
has part: P15531
has only substance units: false
has part: P22392
name: NME1:NME2
is: SBO:0000297
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:4830
initial amount: NaN
is encoded by: hsa:4831

http://identifiers.org/biomodels.db/MODEL1310110005#_7aae7f13_bab7_4df6_85c7_67710421f491
boundary condition: true
type: Species
name: ESCO2
is: SBO:0000252
is encoded by: hsa:157570
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: Q56NI9

metaM amp c
type: Species
boundary condition: false
name: AMP
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: SBO:0000247
has only substance units: false
is: C00020
constant: false
is: HMDB00045
initial concentration: 1.0
is: CHEBI:3322
initial amount: NaN

metaM arg L e
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: HMDB00517
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
name: L-argininium(1+)
boundary condition: false
constant: false
is: CHEBI:32682
type: Species
initial concentration: 1.0

metaM acgam l
name: N-acetyl-D-glucosamine
boundary condition: false
is: HMDB00215
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:17411
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140

http://identifiers.org/biomodels.db/MODEL1310110005#_a8d6512d_33e2_4c9c_926f_78b6e44c5384
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:T83654
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
name: _T83654_1_e
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_b24887b9_14b6_42c2_9f06_f1a07b056a36
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5106
name: PCK2
is: Q16822
is: SBO:0000252
boundary condition: true

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaR r1547
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#

metaR r2057
reactant: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
reversible: false
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110005#
fast: false

metaR r0009
fast: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.1
reversible: false
is: SBO:0000176
modifier: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
name: Pyrophosphate phosphohydrolase EC:3.6.1.1

metaR G3PD1
type: Reaction
product: MODEL1310110005#
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000269
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
fast: false
reversible: true
name: glycerol-3-phosphate dehydrogenase (NAD)
is version of: http://identifiers.org/ec-code/1.1.1.8
is: SBO:0000176

metaM mthgxl e
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: HMDB01167
constant: false
is: CHEBI:17158
initial concentration: 1.0
boundary condition: false
name: methylglyoxal
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_36d3eb1e_577a_4b45_946a_fca2943eb635
has only substance units: false
is encoded by: hsa:122481
boundary condition: true
name: AK7
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is: Q96M32

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaR FOLt2le
product: MODEL1310110005#
type: Reaction
name: folate transport via anion exchange
is: SBO:0000185
is described by: ECO:0000134
fast: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_4754d093_0682_427d_a709_b2aaf4b6242d
initial amount: NaN
is encoded by: hsa:5160
name: DLAT:DLD:PDHA1:PDHB:PDHX
constant: false
has only substance units: false
type: Species
has part: P08559
is: SBO:0000297
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_3c9ce10a_e1a1_4c12_ab4b_53a0584e766c
name: MECR
initial concentration: NaN
is encoded by: hsa:51102
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is: Q9BV79
constant: false

metaR r1546
product: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_b08f54bb_672a_4686_8d09_113aa6dd32b1
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000297
initial amount: NaN
name: NME1:NME2
type: Species
boundary condition: true
is encoded by: hsa:4830

http://identifiers.org/biomodels.db/MODEL1310110005#_7790a976_4842_4019_ae22_5debfb7af6a1
has only substance units: false
initial amount: NaN
is: O00217
initial concentration: NaN
name: NDUFS8
is encoded by: hsa:4728
type: Species
is: SBO:0000252
boundary condition: true
constant: false

metaR GLUDxm
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is described by: ECO:0000269
name: glutamate dehydrogenase (NAD) (mitochondrial)
modifier: MODEL1310110005#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110005#
reversible: true
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.4.1.3

http://identifiers.org/biomodels.db/MODEL1310110005#_b42df0d9_982f_428a_89cb_9ff46932cea8
initial amount: NaN
is: SBO:0000252
name: HADH
is encoded by: hsa:3033
initial concentration: NaN
is: Q16836
constant: false
has only substance units: false
boundary condition: true
type: Species

metaR THFtm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000185
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
reactant: MODEL1310110005#
is described by: ECO:0000000
reversible: true
product: MODEL1310110005#

metaR D3AIBTm
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
reactant: MODEL1310110005#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_291aa396_7951_4ebe_ad1e_49025e0c42c6
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:AV717590
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
name: _AV717590_1_m

http://identifiers.org/biomodels.db/MODEL1310110005#_57d5355a_e50f_4238_b786_99a3b0f5603e
initial amount: NaN
boundary condition: true
is encoded by: hsa:223
is: SBO:0000252
is: P49189
has only substance units: false
constant: false
type: Species
initial concentration: NaN
name: ALDH9A1

http://identifiers.org/biomodels.db/MODEL1310110005#_52e9e030_8baa_49e8_8846_e79b7d76711e
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AI924226
has only substance units: false
name: _AI924226_1_m
boundary condition: true
initial concentration: NaN

metaR r1813
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000

metaR r0728
is: SBO:0000176
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110005#
reversible: true
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaR BAAT4x
product: MODEL1310110005#
name: bile acid Coenzyme A: amino acid N-acyltransferase
is described by: ECO:0000304
modifier: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
fast: false
kinetic law: MODEL1310110005#

metaR GLYC3Ptmc
kinetic law: MODEL1310110005#
is described by: ECO:0000134
product: MODEL1310110005#
type: Reaction
reversible: true
name: glycerol-3-phopshate transport, cytoplasm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.
reactant: MODEL1310110005#
is: SBO:0000185
fast: false

metaM amp e
is: SBO:0000247
boundary condition: false
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
name: AMP
is: HMDB00045
is: C00020
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaR LYStip
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
reactant: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
is described by: ECO:0000000
name: L-lysine transport, peroxisomal (irreversible)
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_df085f48_6e98_43a3_b5d7_4e08ecab3bbc
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:J03866
type: Species
constant: false
has only substance units: false
boundary condition: true
name: _J03866_1_m
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_a99cfabb_1e27_461e_a0c1_04b7831cf38f
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: SLC28A3
is: SBO:0000252
type: Species
is: Q9HAS3
is encoded by: hsa:64078
boundary condition: true

metaM malthx e
constant: false
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
is: SBO:0000247
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
initial concentration: 1.0
is: C01936
name: Maltohexaose
type: Species
initial amount: NaN
has only substance units: false

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaR GTHPm
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.12
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
fast: false
is: SBO:0000176
reversible: true
reactant: MODEL1310110005#
is described by: ECO:0000269
modifier: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.11.1.15
name: glutathione peroxidase, mitochondria

metaR DTMPK
fast: false
is described by: ECO:0000269
reactant: MODEL1310110005#
product: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.9
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: dTMP kinase
type: Reaction
is: SBO:0000176
modifier: MODEL1310110005#

metaR r1549
is: SBO:0000185
reactant: MODEL1310110005#
is described by: ECO:0000000
product: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM trdrd c
is: C00342
boundary condition: false
constant: false
initial amount: NaN
name: Reduced thioredoxin
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
type: Species
is: CHEBI:15967

http://identifiers.org/biomodels.db/MODEL1310110005#_cee22af2_1eee_4536_8f27_8ca32167ea8d
type: Species
constant: false
name: COX6A1
boundary condition: true
has only substance units: false
is: P12074
is encoded by: hsa:1337
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_c1c286f9_b96f_454e_a855_f8b75057d110
boundary condition: true
is: P37268
is encoded by: hsa:2222
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
name: FDFT1

http://identifiers.org/biomodels.db/MODEL1310110005#_b8105db2_6be7_4ae4_9a11_8a98bdb690a9
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:2877
is: SBO:0000252
constant: false
is: P18283
name: GPX2
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_89a0dc5b_0590_4b05_abc1_6c01c4ee1d1e
initial concentration: NaN
type: Species
is encoded by: hsa:493
constant: false
boundary condition: true
is: SBO:0000252
is: P23634
initial amount: NaN
name: ATP2B4
has only substance units: false

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaR r0660
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110005#
product: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2
kinetic law: MODEL1310110005#
reversible: true
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
reactant: MODEL1310110005#

metaM h x
boundary condition: false
name: proton
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: C00080

http://identifiers.org/biomodels.db/MODEL1310110005#_7cff7f3e_611b_4791_993b_d73eae050598
type: Species
name: _AI291895_1_c
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI291895

metaM arachdcoa m
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: HMDB06523
name: arachidonoyl-CoA(4-)
is: CHEBI:57368
type: Species

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM mlthf c
initial concentration: 1.0
is: HMDB01533
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
name: 5,10-Methylenetetrahydrofolate
boundary condition: false
is: C00143
has only substance units: false
constant: false
is: CHEBI:15636

metaM dcholcoa c
boundary condition: false
type: Species
is: HMDB06292
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
name: chenodeoxycholoyl coenzyme a
is: SBO:0000247
is: CHEBI:28701
initial amount: NaN

metaR r1548
reversible: true
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110005#
is described by: ECO:0000000
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_d153d5cb_ac8f_4c57_9088_bf03b14a6862
constant: false
is: SBO:0000252
is: P07864
initial concentration: NaN
is encoded by: hsa:3948
type: Species
initial amount: NaN
has only substance units: false
name: LDHC
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_129f1ab5_6d26_4b87_8bb6_f67f10ed5b68
is encoded by: hsa:4710
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is: O95168
has only substance units: false
constant: false
name: NDUFB4

metaR RE1233C
is: SBO:0000176
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110005#
modifier: MODEL1310110005#
name: RE1233
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110005#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_e0f555e0_adca_4663_a80f_ee3689416c46
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:129642
name: MBOAT2
constant: false
initial concentration: NaN
is: Q6ZWT7
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_5bf5bab0_9c19_483a_b43a_201862c53ed1
name: ATP10A
is: O60312
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:57194
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_79ac71c5_295d_4613_aa15_c647f6290c5e
boundary condition: true
initial concentration: NaN
has only substance units: false
is: Q546Y9
initial amount: NaN
constant: false
name: AICDA
is encoded by: hsa:57379
is: SBO:0000252
type: Species

metaM lthstrl r
boundary condition: false
name: 5alpha-cholest-7-en-3beta-ol
initial concentration: 1.0
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:17168
is: HMDB01170

metaM CE1944 c
is: CHEBI:36781
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
type: Species
name: 1-pyrrolinium
constant: false
has only substance units: false
is: SBO:0000247

metaR NDPK4n
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110005#
reversible: true
is described by: ECO:0000304
fast: false
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
is: SBO:0000176

metaM dmnoncrn x
type: Species
name: 4,8-dimethylnonanoyl carnitine
is: HMDB06202
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C18H37NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110005#_dc0bf478_52ef_4ccf_ba0b_91d43502d77b
boundary condition: true
initial concentration: NaN
is: Q6P1K9
initial amount: NaN
is encoded by: hsa:80025
is: SBO:0000252
has only substance units: false
constant: false
name: PANK2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_a4860507_9454_492e_8150_02144de5f518
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SLC23A1
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:9963
is: Q9UHI7

metaR r2053
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
is: SBO:0000185
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
type: Reaction

metaM glyc R c
initial concentration: 1.0
boundary condition: false
name: D-glycerate
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: CHEBI:16659
type: Species
is: HMDB00139
has only substance units: false

metaM dhap m
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
is: HMDB01473
name: Dihydroxyacetone phosphate
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3411
is: SBO:0000247
is: C00111
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_a2048928_166c_466f_9d13_7a8e65b8ef37
constant: false
initial amount: NaN
name: AADAT
type: Species
is encoded by: hsa:51166
is: Q4W5N8
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM cl c
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: HMDB00492
is: C00115
boundary condition: false
is: CHEBI:3966
name: Chloride
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: Cl CHARGE: -1

metaM f1p c
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00662 EHMN_ABBREVIATION: C01094
initial concentration: 1.0
name: D-Fructose 1-phosphate
initial amount: NaN
is: C01094
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB01076
is: CHEBI:18105
has only substance units: false

metaR BAMPPALDOX
is: SBO:0000176
is described by: ECO:0000212
modifier: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
product: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
type: Reaction
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.2.1.36

http://identifiers.org/biomodels.db/MODEL1310110005#_b1d96f50_a5b0_42cc_9a1f_0f771a655b27
is: SBO:0000252
type: Species
name: MTR
is: Q99707
initial amount: NaN
is encoded by: hsa:4548
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

metaR CYTK3n
name: cytidylate kinase (dCMP,CTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
fast: false
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: true

metaR DM dttp m
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

metaM txa2 c
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
is: HMDB01452
name: thromboxane A2(1-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
constant: false
is: CHEBI:57445

http://identifiers.org/biomodels.db/MODEL1310110005#_dd819d50_1f0e_4f90_a3c4_6ae419b656bf
is encoded by: hsa:4724
boundary condition: true
type: Species
name: NDUFS4
is: O43181
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_c9aa6d3a_bbee_4535_a82e_f07f6afe10e6
is: Q9NT06
constant: false
name: HMGCLL1
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:54511

metaM arg L c
constant: false
is: SBO:0000247
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
name: L-argininium(1+)
type: Species
is: HMDB00517
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:32682
has only substance units: false

metaR r2055
reactant: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaM mthgxl c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: methylglyoxal
is: CHEBI:17158
boundary condition: false
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
is: HMDB01167
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_4d5dd05a_a418_485d_9da1_75015d176d10
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q9H6Y6
is encoded by: hsa:4645
has only substance units: false
type: Species
name: MYO5B
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_5486fda2_2415_417a_ac74_b2cae5f58836
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ECI2
is: O75521
constant: false
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:10455

http://identifiers.org/biomodels.db/MODEL1310110005#_3f4f30fd_dbac_42aa_b53c_b5b7b0c56ec2
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
name: _AA502753_1_m
is encoded by: hsa:AA502753
initial concentration: NaN

metaR r2311
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_04de0044_16e6_4461_bddf_9a12db66c266
initial concentration: NaN
name: COX7B2
has only substance units: false
is encoded by: hsa:170712
boundary condition: true
is: Q8TF08
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

metaR SERLYSNaex
modifier: MODEL1310110005#
product: MODEL1310110005#
fast: false
is described by: ECO:0000212
name: Serine/Lysine Na-dependent exchange (Ser in)
type: Reaction
reactant: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9056.1 and 6519.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310

metaR r1380
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000176
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_6b9884d6_31e9_41ad_be24_8670f2e828fb
is encoded by: hsa:2643
boundary condition: true
is: Q8IZH9
initial amount: NaN
has only substance units: false
name: GCH1
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252

metaM akg e
is: SBO:0000247
is: HMDB00208
initial amount: NaN
is: CHEBI:16810
has only substance units: false
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
name: 2-oxoglutarate(2-)
constant: false
initial concentration: 1.0

metaR CHOLt4
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110005#
fast: false
type: Reaction
modifier: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
name: choline, sodium cotransport
reactant: MODEL1310110005#
reversible: true

metaM methf m
is: SBO:0000247
constant: false
name: (6R)-5,10-methenyltetrahydrofolate
is: HMDB01354
initial concentration: 1.0
boundary condition: false
is: CHEBI:57455
type: Species
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
has only substance units: false
initial amount: NaN

metaR FRDPtc
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: lipid, flip-flop intracellular transport
reversible: true

metaR MTHFC
fast: false
kinetic law: MODEL1310110005#
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
name: methenyltetrahydrofolate cyclohydrolase
is version of: http://identifiers.org/ec-code/1.5.1.5
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
type: Reaction
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000134
product: MODEL1310110005#

metaR FRUt4
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
fast: false
name: D-fructose transport via sodium cotransport
modifier: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000269

metaM cl e
initial amount: NaN
has only substance units: false
boundary condition: false
name: Chloride
is: CHEBI:3966
constant: false
notes: FORMULA: Cl CHARGE: -1
type: Species
initial concentration: 1.0
is: C00115
is: HMDB00492
is: SBO:0000247

metaR EX udp LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP exchange
type: Reaction

metaR NICRNS
is described by: ECO:0000000
name: NICRNS
product: MODEL1310110005#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
reversible: false

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_8beba20f_dc9f_419b_b89c_71c5b5058853
initial concentration: NaN
is encoded by: hsa:10246
name: SLC17A2
boundary condition: true
is: O00624
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_4544f08b_e0e4_4e86_ad5b_4c9e6e10d309
name: GRHPR
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:9380
is: Q9UBQ7
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaR r2310
type: Reaction
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR r1381
is: SBO:0000176
fast: false
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
type: Reaction
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_2dfe859e_5f13_479d_ada2_a3e9b5a7be5a
initial amount: NaN
is: P53794
type: Species
is: SBO:0000252
boundary condition: true
name: SLC5A3
initial concentration: NaN
constant: false
is encoded by: hsa:6526
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_dfd304a6_cdc1_4dd8_8b13_3a744a7d2c8b
is encoded by: hsa:1962
constant: false
is: Q9NY65
initial amount: NaN
has only substance units: false
boundary condition: true
name: EHHADH
type: Species
is: SBO:0000252
initial concentration: NaN

metaR LEUKTRA4t
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
reactant: MODEL1310110005#
reversible: true
is described by: ECO:0000269
name: leukotriene A4 transport

http://identifiers.org/biomodels.db/MODEL1310110005#_8ba06f31_8bf7_41b5_9772_cbf99e292430
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AL050025
constant: false
name: _AL050025_1_c
boundary condition: true
type: Species
initial amount: NaN

metaR ADNt
reversible: true
type: Reaction
is: SBO:0000185
name: adenosine facilated transport in cytosol
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
modifier: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
is described by: ECO:0000269

metaR r0474
is described by: ECO:0000000
kinetic law: MODEL1310110005#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
type: Reaction

metaM clpndcoa c
constant: false
type: Species
name: clupanodonyl CoA
initial concentration: 1.0
is: SBO:0000247
is: HMDB06267
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205476
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
has only substance units: false
is: C16166

metaM ppi n
boundary condition: false
initial amount: NaN
is: HMDB00250
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:33019
type: Species
name: diphosphate(3-)
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013

http://identifiers.org/biomodels.db/MODEL1310110005#_f49a3fdc_69e9_4e96_a94f_517021760fdc
is encoded by: hsa:6582
name: SLC22A2
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

metaM 4abutn c
has only substance units: false
initial concentration: 1.0
name: 4-Aminobutanal
constant: false
is: HMDB01080
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: SBO:0000247
is: CHEBI:58264
is: C00555

metaM 4mop e
type: Species
initial amount: NaN
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
has only substance units: false
name: 4-methyl-2-oxopentanoate
is: HMDB00695
boundary condition: false
initial concentration: 1.0
is: CHEBI:17865
constant: false
is: SBO:0000247

metaM arachdcrn c
is: HMDB01322
boundary condition: false
has only substance units: false
constant: false
type: Species
name: C20:4 carnitine
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial amount: NaN
is: SBO:0000247
is: CHEBI:57387
initial concentration: 1.0

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaR SBTR
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.21
name: D-sorbitol reductase
reactant: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
kinetic law: MODEL1310110005#

metaR OROTGLUt
kinetic law: MODEL1310110005#
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110005#
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110005#
name: OROTGLUt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaR NAHCO3 HCLt
name: bicarbonate transport (HCl/NaHCO3 exchange)
fast: false
reactant: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
is described by: ECO:0000269
kinetic law: MODEL1310110005#
reversible: true
type: Reaction
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_f1bfead9_05a7_4667_85a1_a2ecd2fdca19
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6241
name: RRM2
boundary condition: true
constant: false
type: Species
is: P31350
initial amount: NaN
is: SBO:0000252

metaR AGTim
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
reversible: false
is described by: ECO:0000269
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
product: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.44
reactant: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
fast: false

metaM taur x
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
name: taurine
constant: false
is: HMDB00251
boundary condition: false
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
is: CHEBI:15891

metaR r2128
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false

metaR CRNrtx
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
product: MODEL1310110005#
name: reversible transport of L-Carnitine in peroxisome
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_aeb107f4_68e5_4127_a3e7_af4ea1f64b01
type: Species
is encoded by: hsa:6319
is: O00767
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: SCD
has only substance units: false

metaR FAOXC16080m
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
kinetic law: MODEL1310110005#
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
product: MODEL1310110005#

metaR ITCOALm
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4
is version of: http://identifiers.org/ec-code/6.2.1.5
product: MODEL1310110005#
is: SBO:0000176
fast: false
reversible: true
modifier: MODEL1310110005#
is described by: ECO:0000212
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD

metaR BAAT1x
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
is described by: ECO:0000269
name: bile acid Coenzyme A: amino acid N-acyltransferase
product: MODEL1310110005#
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.65

metaR r0839
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
is: SBO:0000185
product: MODEL1310110005#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.70
reversible: true
reactant: MODEL1310110005#
name: Postulated transport reaction
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_3075729e_9879_46e3_9a26_5e9a6102f43a
constant: false
has part: P15531
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:4830
name: NME1:NME2
has part: P22392
boundary condition: true
is encoded by: hsa:4831

metaM ppi m
constant: false
is: CHEBI:33019
type: Species
is: SBO:0000247
is: C00013
initial concentration: 1.0
initial amount: NaN
name: Diphosphate
boundary condition: false
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_bf85753f_9a15_45ba_8b2c_db2389b5a39c
is: D3DTL2
name: ENO3
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:2027
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR ADEt
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110005#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
reactant: MODEL1310110005#
name: adenine reversible transport, cytosol
is described by: ECO:0000269

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_703b2563_1804_4038_a188_c84a9ce88ef1
constant: false
is: SBO:0000252
is encoded by: hsa:4199
boundary condition: true
name: ME1
type: Species
is: P48163
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM HC01408 m
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
is: CHEBI:27648
is: SBO:0000247
name: 3-Oxohexanoyl-CoA
constant: false
initial amount: NaN
boundary condition: false

metaM amp r
name: AMP
type: Species
is: CHEBI:456215
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00045
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
is: C00020
is: SBO:0000247

metaR r2129
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110005#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_9471bcda_4c22_4ed7_8804_68c50fbcdc34
initial amount: NaN
has only substance units: false
name: ALDH3B1
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is: P43353
is encoded by: hsa:221

metaM mal L m
boundary condition: false
is: HMDB00156
initial concentration: 1.0
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial amount: NaN
type: Species
is: CHEBI:15589
name: (S)-malate(2-)
constant: false
is: SBO:0000247
has only substance units: false

metaM atp x
is: CHEBI:57299
is: C00002
has only substance units: false
is: SBO:0000247
name: ATP(4-)
is: HMDB00538
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_7d076412_e453_442c_8cf0_eae6ca4f4488
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is: Q13011
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:1891
name: ECH1

metaR ECOAH12m
product: MODEL1310110005#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
reactant: MODEL1310110005#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000304
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
kinetic law: MODEL1310110005#

metaM 3aib m
boundary condition: false
name: (S)-3-aminoisobutyric acid
is: CHEBI:33094
is: HMDB02166
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284

metaR ARGLYSex
reactant: MODEL1310110005#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
reversible: false
name: Arginine/Lysine exchanger (Arg in)
fast: false
is: SBO:0000185
type: Reaction

metaM bilglcur e
initial amount: NaN
is: CHEBI:57767
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
name: mono(glucosyluronic acid)bilirubin(2-)
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaR SQLSr
name: Squalene synthase
modifier: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.5.1.21
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
fast: false
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_6874c119_fa2f_4d06_bd9a_75a390364e3b
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is: Q59EH3
is encoded by: hsa:52
type: Species
name: ACP1
boundary condition: true
initial amount: NaN

metaR r0365
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110005#

metaR PPDOx
type: Reaction
reactant: MODEL1310110005#
is: SBO:0000176
product: MODEL1310110005#
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
modifier: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
is described by: ECO:0000269
fast: false

metaM nh4 x
is: C01342
is: SBO:0000247
is: HMDB00051
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
is: CHEBI:28938
type: Species
boundary condition: false
name: Ammonium

http://identifiers.org/biomodels.db/MODEL1310110005#_16cc6284_3eb0_47ee_98df_e891a06f1e4d
name: CDO1
boundary condition: true
constant: false
is: SBO:0000252
is: Q16878
initial concentration: NaN
is encoded by: hsa:1036
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_100ce147_2f2b_4adb_a080_f17144c85075
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:10050
is: Q9Y2C5
name: SLC17A4
initial amount: NaN
type: Species
constant: false

metaM na1 c
constant: false
is: C01330
is: HMDB00588
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: Na CHARGE: 1
is: CHEBI:4541
boundary condition: false
type: Species
name: Sodium
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_d5fe8507_fe0a_4861_ae0e_fcd5bd8b01e1
name: ACOT4
boundary condition: true
type: Species
is: Q8N9L9
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:122970

metaR r2139
product: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
modifier: MODEL1310110005#
reversible: true

metaR r2126
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
is described by: ECO:0000000
reversible: true
product: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaM but e
type: Species
constant: false
is: CHEBI:17968
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00039
initial concentration: 1.0

metaR RE1526M
fast: false
name: RE1526
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110005#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110005#_0d63b3df_a7c5_4a86_86de_b986809debb6
constant: false
type: Species
has part: P31040
is encoded by: hsa:6392
is encoded by: hsa:6389
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6390
is: SBO:0000297
has only substance units: false
is encoded by: hsa:6391
has part: P21912
name: SDHA:SDHB:SDHC:SDHD
boundary condition: true
has part: Q99643
has part: O14521

metaR r0475
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110005#

metaM 2dr5p c
boundary condition: false
is: HMDB01031
name: 2-deoxy-D-ribose 5-phosphate(2-)
is: SBO:0000247
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
is: CHEBI:57651
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_931b55a0_bb65_4a3f_a9d8_5c2ac8fa36d4
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
name: GK3P
boundary condition: true
is encoded by: hsa:2713
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_3f819c2c_58d7_453b_b43f_0241ea4f8de9
initial amount: NaN
is encoded by: hsa:115111
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
has only substance units: false
name: SLC26A7
boundary condition: true

metaM CE2421 m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02329
name: (3S)-3-hydroxylinoleoyl-CoA
constant: false
initial amount: NaN
is: CHEBI:30623
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_8b68e1cf_f883_48ae_9e6c_79eab2ab4c33
type: Species
name: ACADM
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P11310
initial amount: NaN
is encoded by: hsa:34
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_4f45c4e7_a38d_474b_a655_b1c843f07387
is encoded by: hsa:6535
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: SLC6A8
is: B4DIA3
type: Species

metaR r2127
modifier: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110005#
is described by: ECO:0000000

metaM lnlncgcoa c
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: CHEBI:57363
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR TPI
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
type: Reaction
modifier: MODEL1310110005#
is described by: ECO:0000134
name: triose-phosphate isomerase
kinetic law: MODEL1310110005#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.1.1
product: MODEL1310110005#
reversible: true

metaR r0838
type: Reaction
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.1.2.4
name: Free diffusion
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
is: SBO:0000185

metaM bilglcur c
is: SBO:0000247
is: CHEBI:57767
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
name: mono(glucosyluronic acid)bilirubin(2-)

metaR r0145
fast: false
is described by: ECO:0000000
reactant: MODEL1310110005#
type: Reaction
reversible: true
product: MODEL1310110005#
is: SBO:0000176
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
is version of: http://identifiers.org/ec-code/1.8.3.1
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_c172d14b_dd89_42ec_94bd_c1d0a3c3284a
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:6560
constant: false
name: SLC12A4
is: SBO:0000252
is: F5H066
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_b7a38e38_960e_4f6a_bf51_d5ea84ba12b5
has only substance units: false
is encoded by: hsa:728226
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: _728226_1_m

metaR EICOSTETt
name: fatty acid transport via diffusion
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
product: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
is: SBO:0000185

metaM c226crn c
is: HMDB06510
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
is: http://identifiers.org/pubchem.compound/127055
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: cervonyl carnitine

metaM ura c
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: C00106
initial amount: NaN
boundary condition: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
type: Species
is: HMDB00300
name: Uracil
is: CHEBI:17568

http://identifiers.org/biomodels.db/MODEL1310110005#_2165cd62_62b5_43b9_a270_78827bb7f45b
is encoded by: hsa:81539
is: SBO:0000252
has only substance units: false
boundary condition: true
name: SLC38A1
initial concentration: NaN
is: Q9H2H9
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_61926412_4432_4f0e_bb3a_106621791320
initial concentration: NaN
is encoded by: hsa:W74642
type: Species
has only substance units: false
is: SBO:0000252
name: _W74642_1_c
constant: false
boundary condition: true
initial amount: NaN

metaR BTNt4i
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
modifier: MODEL1310110005#
name: Biotin uptake (antiport)
reversible: false
is described by: ECO:0000269
product: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_a4b5a415_7bbb_491f_a871_e7e2083e0c61
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P09104
is: SBO:0000252
name: ENO2
type: Species
is encoded by: hsa:2026
boundary condition: true

metaR BGLUTCHLe
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of betaglucans with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR FBA2
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (229.1) or (230.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.1.2.13 Confidence Level: 2 AUTHORS: NOTES:NCD
modifier: MODEL1310110005#
product: MODEL1310110005#
reversible: true
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: MODEL1310110005#
is described by: ECO:0000304
is: SBO:0000176
type: Reaction

metaM amp m
name: AMP(2-)
is: SBO:0000247
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
is: HMDB00045
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false

metaR r2403
is described by: ECO:0000000
product: MODEL1310110005#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_8801a307_a359_442e_8e3f_8f8b09c05f42
boundary condition: true
is: SBO:0000252
name: GPX4
is encoded by: hsa:2879
type: Species
constant: false
has only substance units: false
is: P36969
initial amount: NaN
initial concentration: NaN

metaM 3m4hpga c
is: C05583
is: HMDB04061
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
is: http://identifiers.org/pubchem.compound/7909
boundary condition: false

metaR r2124
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110005#
reversible: true
type: Reaction
kinetic law: MODEL1310110005#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM pi r
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
is: C00009
has only substance units: false
is: CHEBI:43474
boundary condition: false
name: hydrogenphosphate
type: Species
initial concentration: 1.0
is: HMDB00973
is: SBO:0000247

metaR r2137
fast: false
reversible: true
product: MODEL1310110005#
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
is: SBO:0000185

metaM but c
type: Species
name: butyrate
is: SBO:0000247
is: HMDB00039
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
initial amount: NaN
boundary condition: false
is: CHEBI:17968

metaR DOPAt4 2 r
kinetic law: MODEL1310110005#
name: Dopamine reversible transport in via sodium symport (1:2)
reactant: MODEL1310110005#
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110005#
reversible: true
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction

metaM val L m
initial amount: NaN
is: HMDB00883
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:16414
initial concentration: 1.0
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: SBO:0000247
name: L-valine

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR 34DHPLACOX
fast: false
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
product: MODEL1310110005#
reactant: MODEL1310110005#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000269
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase

metaR ITPtn
reversible: true
reactant: MODEL1310110005#
type: Reaction
name: ITP nuclear transport
is: SBO:0000185
kinetic law: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
fast: false

metaR DNDPt35m
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: false
type: Reaction
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dGDP transport via dADP antiport
is described by: ECO:0000269
reactant: MODEL1310110005#
is: SBO:0000185
fast: false

metaR SO4CLtex2
name: sulfate transport via chloride countertransport (2:1)
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: false
is described by: ECO:0000304
fast: false
reactant: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is: SBO:0000185
product: MODEL1310110005#

metaR CITRtm
is described by: ECO:0000269
modifier: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
product: MODEL1310110005#
name: citrulline mitochondrial transport via proton antiport
fast: false
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
kinetic law: MODEL1310110005#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_e8835423_8279_471a_a5fc_985a544ecd49
is: Q9UEF7
has only substance units: false
constant: false
name: KL
is encoded by: hsa:9365
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN

metaM HC02202 c
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
boundary condition: false
name: prostaglandin A1(1-)
initial amount: NaN
is: CHEBI:57398
initial concentration: 1.0
constant: false
has only substance units: false
type: Species

metaR PPDOy
fast: false
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.2
type: Reaction
reactant: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.21
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_6ff000c5_caf2_4528_808b_209c11cc02f3
is encoded by: hsa:956
is: SBO:0000252
type: Species
is: O75355
initial concentration: NaN
has only substance units: false
name: ENTPD3
constant: false
boundary condition: true
initial amount: NaN

metaM 2obut m
is: CHEBI:16763
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
name: 2-oxobutanoate
has only substance units: false
constant: false
is: HMDB00005
initial amount: NaN
initial concentration: 1.0

metaR r2125
type: Reaction
fast: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_fffdf3a9_1fa3_4f40_803e_b0a1f3186348
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:5313
initial concentration: NaN
has only substance units: false
name: PKLR

metaR r2136
reversible: false
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
product: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reactant: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110005#
type: Reaction
fast: false

metaM ura e
is: SBO:0000247
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: uracil
is: HMDB00300
type: Species
boundary condition: false
is: CHEBI:17568
constant: false

metaM ump r
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:57865
is: SBO:0000247
type: Species
name: UMP
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_846a7e21_10d5_45dc_9ca6_be9b14dc01c4
initial amount: NaN
is: Q92911
initial concentration: NaN
constant: false
is encoded by: hsa:6528
type: Species
has only substance units: false
name: SLC5A5
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_cdc5313a_1108_4480_a058_dfddf5942f2d
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:1339
initial amount: NaN
name: COX6A2
type: Species
boundary condition: true
is: SBO:0000252
is: Q02221

metaR THRGLNexR
is described by: ECO:0000304
type: Reaction
name: L-threonine/glycine reversible exchange
is: SBO:0000185
modifier: MODEL1310110005#
product: MODEL1310110005#
reversible: true
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaM prostgd2 r
name: prostaglandin D2(1-)
initial concentration: 1.0
is: HMDB01403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
boundary condition: false
has only substance units: false
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:57406

metaR DTTPtn
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110005#
fast: false
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
name: dTTP diffusion in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaR r2122
fast: false
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110005#
product: MODEL1310110005#
modifier: MODEL1310110005#

metaM L2aadp m
name: L-2-aminoadipate(1-)
constant: false
is: HMDB00510
initial amount: NaN
is: CHEBI:58672
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956

metaM udp n
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
name: UDP(3-)
initial amount: NaN
boundary condition: false
is: HMDB00295
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:58223

http://identifiers.org/biomodels.db/MODEL1310110005#_462ccbbb_a8ce_4a2c_95a9_6ce1946fd50a
constant: false
type: Species
name: _AA664770_1_m
initial amount: NaN
has only substance units: false
is encoded by: hsa:AA664770
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR PROSTGI2tr
is: SBO:0000185
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reversible: true
is described by: ECO:0000269
name: Prostaglandin I2 transport (ER)
fast: false
type: Reaction
product: MODEL1310110005#

metaR FBA4
kinetic law: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (226.2) or (229.1) or (226.3) or (230.1) or (226.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.2.13 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
modifier: MODEL1310110005#
is described by: ECO:0000269
reactant: MODEL1310110005#
fast: false
reversible: true
is: SBO:0000176
type: Reaction
name: D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
is version of: http://identifiers.org/ec-code/4.1.2.13

metaM didp n
is: CHEBI:28823
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
name: dIDP
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB03536

http://identifiers.org/biomodels.db/MODEL1310110005#_416a4d79_3379_4b1c_8a0b_03f4a4f82666
initial amount: NaN
constant: false
is encoded by: hsa:1719
name: DHFR
type: Species
is: P00374
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_5f82de02_242a_4104_b9ce_41ea04b9049d
boundary condition: true
is encoded by: hsa:116369
type: Species
is: SBO:0000252
constant: false
name: SLC26A8
initial amount: NaN
is: Q96RN1
has only substance units: false
initial concentration: NaN

metaR P450SCC1m
reactant: MODEL1310110005#
reversible: true
is described by: ECO:0000134
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
kinetic law: MODEL1310110005#
name: cholesterol monooxygenase
product: MODEL1310110005#

metaR r0142
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110005#
type: Reaction
modifier: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false

metaM HC02202 e
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false
boundary condition: false
initial amount: NaN
name: prostaglandin A1(1-)
is: CHEBI:57398
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_9b58c6e1_53aa_4ca7_aeda_4a3aa522cdef
is: E5KS60
type: Species
name: SUCLA2
initial amount: NaN
is encoded by: hsa:8803
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaR KYNATESYN
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
product: MODEL1310110005#
kinetic law: MODEL1310110005#
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
fast: false
reactant: MODEL1310110005#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110005#_d11072aa_b4b1_40a0_8383_0452bc925384
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:33
is: SBO:0000252
name: ACADL
type: Species
has only substance units: false
is: P28330

http://identifiers.org/biomodels.db/MODEL1310110005#_fc8f227a_6668_40d4_b2eb_fa643bf79c10
constant: false
type: Species
name: GGT7
initial concentration: NaN
boundary condition: true
is: A0PJJ9
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2686
initial amount: NaN

metaR r1172
reactant: MODEL1310110005#
is: SBO:0000176
name: EC:3.1.1.13
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
type: Reaction
product: MODEL1310110005#
fast: false

metaM 1pyr5c m
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: C03912
is: HMDB01301
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:15893
name: 1-Pyrroline-5-carboxylate
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912

metaR r2123
kinetic law: MODEL1310110005#
type: Reaction
fast: false
modifier: MODEL1310110005#
reactant: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_32757bfb_2ee3_4e31_8982_48addb6c85f7
constant: false
name: TPI1P2
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:286016
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR ATPtm
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reversible: false
name: ADP/ATP transporter, mitochondrial
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reactant: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_a90c8e05_e3e9_4442_b28b_99f4ad1d9f84
is encoded by: hsa:57835
is: Q9BY07
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: SLC4A5
constant: false
initial amount: NaN

metaR r2133
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110005#
type: Reaction
fast: false
reactant: MODEL1310110005#
is: SBO:0000185

metaR DGK1
fast: false
is: SBO:0000176
product: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.8
name: deoxyguanylate kinase (dGMP:ATP)
reversible: true
type: Reaction
modifier: MODEL1310110005#

metaM pi n
is: HMDB00973
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
name: hydrogenphosphate
has only substance units: false

metaR r2120
type: Reaction
fast: false
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110005#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_73066c63_553d_45b7_8af3_aea5e5036550
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:56895
type: Species
name: AGPAT4
has only substance units: false
boundary condition: true
is: Q9NRZ5

metaR r0587
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
is: SBO:0000176
modifier: MODEL1310110005#
reversible: true
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
fast: false
product: MODEL1310110005#
is described by: ECO:0000000

metaM mal L e
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:15589
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
constant: false
is: HMDB00156
name: (S)-malate(2-)

metaR HIStiDF
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000185
fast: false
reversible: false
product: MODEL1310110005#
is described by: ECO:0000269
reactant: MODEL1310110005#
name: L-histidine transport via diffusion (extracellular to cytosol)

http://identifiers.org/biomodels.db/MODEL1310110005#_44c9629a_8cd8_4479_81c9_25b9de1d6fa4
has only substance units: false
type: Species
boundary condition: true
name: DPYSL2
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:1808
is: B4DR31
is: SBO:0000252

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_3b05bfd2_1226_4d8a_9607_38f067c11cd8
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:U52111
name: _U52111_1_c
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaM met L c
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
name: L-methionine
initial amount: NaN
is: HMDB00696
is: CHEBI:16643
type: Species
boundary condition: false

metaM adp x
is: CHEBI:456216
constant: false
is: HMDB01341
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
name: ADP(3-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_a7f7148a_f14a_426d_9f96_4d4a53973785
initial concentration: NaN
is: SBO:0000252
is: P43353
name: ALDH3B1
boundary condition: true
constant: false
type: Species
has only substance units: false
is encoded by: hsa:221
initial amount: NaN

metaR r1621
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110005#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaM nh4 m
is: C01342
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
initial amount: NaN
is: HMDB00051
name: Ammonium
has only substance units: false

metaM creat e
boundary condition: false
type: Species
name: creatine
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: HMDB00064
constant: false
is: CHEBI:16919
initial concentration: 1.0
initial amount: NaN

metaM creat c
has only substance units: false
is: HMDB00064
type: Species
is: SBO:0000247
is: CHEBI:16919
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
boundary condition: false
name: creatine
constant: false
initial amount: NaN
initial concentration: 1.0

metaR DPCOAtl
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
kinetic law: MODEL1310110005#
name: dephospho-CoA transport from lysosome via diffusion
type: Reaction
reactant: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000

metaR q10tm
fast: false
name: transport of ubiquinone into mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110005#
reversible: true
reactant: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
product: MODEL1310110005#

metaR r2132
type: Reaction
reactant: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
product: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaM pmtcrn x
boundary condition: false
has only substance units: false
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
is: CHEBI:17490
name: L-palmitoylcarnitine
initial concentration: 1.0

metaM 3aib e
has only substance units: false
is: HMDB02166
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
type: Species
name: (S)-3-aminoisobutyric acid
is: CHEBI:33094
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284

http://identifiers.org/biomodels.db/MODEL1310110005#_d5fdb255_c996_416a_a87f_cd072ed76c30
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:19
is: O95477
name: ABCA1
has only substance units: false
type: Species
initial amount: NaN

metaR r2121
type: Reaction
kinetic law: MODEL1310110005#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110005#
product: MODEL1310110005#

metaM fad m
is: SBO:0000247
name: Flavin adenine dinucleotide oxidized
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
type: Species
is: CHEBI:16238
boundary condition: false
is: C00016
is: HMDB01248
initial concentration: 1.0
initial amount: NaN

metaR r2408
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
is: SBO:0000185
reversible: false
modifier: MODEL1310110005#
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_6a644054_329e_4935_9c2f_2528e35b3468
initial concentration: NaN
name: ALDH3A2
is: P51648
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:224

metaM HC02206 e
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:57399
type: Species
initial concentration: 1.0
constant: false
name: prostaglandin C1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
is: SBO:0000247

metaR r1622
product: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110005#

metaM gdp c
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
is: C00035
type: Species
has only substance units: false
name: GDP
boundary condition: false
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: CHEBI:58189

metaM ppi e
is: SBO:0000247
is: C00013
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:33019
type: Species
is: HMDB00250
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
initial amount: NaN

metaR RAI2
product: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
name: retinal isomerase (9-cis)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110005#
is: SBO:0000176
type: Reaction

metaR MCCCrm
is version of: http://identifiers.org/ec-code/6.4.1.4
type: Reaction
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
modifier: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
reversible: true
name: methylcrotonoyl-CoA carboxylase, mitochondrial
fast: false
is described by: ECO:0000269

metaM 4abutn m
is: HMDB01080
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: 4-ammoniobutanal
type: Species
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
has only substance units: false
is: CHEBI:58264

metaM pi l
has only substance units: false
initial amount: NaN
name: hydrogenphosphate
constant: false
initial concentration: 1.0
is: CHEBI:43474
boundary condition: false
is: HMDB00973
is: SBO:0000247
type: Species
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

metaR r2131
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
product: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

http://identifiers.org/biomodels.db/MODEL1310110005#_cc21fd32_05a7_474c_9835_0935d077e7ca
has only substance units: false
name: COX4I2
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: Q96KJ9
is encoded by: hsa:84701
type: Species

metaM mal L c
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00156
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
boundary condition: false
constant: false
name: (S)-malate(2-)
initial amount: NaN
is: SBO:0000247

metaM retinol 9 cis c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
boundary condition: false
type: Species
is: SBO:0000247
name: 9-cis-retinol
initial concentration: 1.0
constant: false
is: CHEBI:17336
has only substance units: false
initial amount: NaN
is: HMDB06217

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaR RAI1
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
is described by: ECO:0000000
name: retinal isomerase (11-cis)
fast: false
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110005#_7b3f05e5_dbd1_439a_ac90_7c4a5886a01a
boundary condition: true
initial concentration: NaN
name: SLC19A3
type: Species
has only substance units: false
constant: false
is encoded by: hsa:80704
is: SBO:0000252
is: Q9BZV2
initial amount: NaN

metaM ca2 c
is: SBO:0000247
initial concentration: 1.0
is: HMDB00464
initial amount: NaN
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
has only substance units: false
is: CHEBI:29108
name: calcium(2+)
type: Species
constant: false
boundary condition: false

metaR AMETtd
is described by: ECO:0000134
product: MODEL1310110005#
name: diffusion of S-Adenosyl-L-methionine
is: SBO:0000185
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110005#

metaM ump n
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:57865
initial amount: NaN
name: UMP(2-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_e6ddf48b_2d8c_47a8_9a31_580fe9b41e51
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:284111
constant: false
has only substance units: false
is: Q86YT5
name: SLC13A5
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_19b7c46e_5ca0_40fd_a51d_80edc43104ee
is encoded by: hsa:1103
has only substance units: false
constant: false
is: Q6LEN6
name: CHAT
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species

metaM thf c
initial concentration: 1.0
is: CHEBI:57453
boundary condition: false
is: HMDB01846
has only substance units: false
initial amount: NaN
constant: false
type: Species
name: 5,6,7,8-Tetrahydrofolate
is: C00101
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: SBO:0000247

metaR 5MTHFt2le
type: Reaction
name: 5-methyltetrahydrofolate transport via anion exchange
is: SBO:0000185
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM amp x
name: AMP
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:456215
initial amount: NaN
has only substance units: false
is: HMDB00045
is: C00020
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_a21d912b_5412_4105_872a_9c3174109061
initial concentration: NaN
has only substance units: false
name: HSD3B2
boundary condition: true
is: P26439
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:3284
constant: false

metaR TDCHOLAtx
kinetic law: MODEL1310110005#
is: SBO:0000185
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
reversible: true
type: Reaction
reactant: MODEL1310110005#
is described by: ECO:0000000

metaM 3aib c
is: CHEBI:33094
is: HMDB02166
initial amount: NaN
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
name: (S)-3-aminoisobutyric acid
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
has only substance units: false

metaM pi m
has only substance units: false
boundary condition: false
is: CHEBI:43474
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
name: hydrogenphosphate
is: C00009
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
constant: false

metaM met L e
boundary condition: false
is: CHEBI:16643
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
type: Species
name: L-methionine
is: SBO:0000247
is: HMDB00696
initial concentration: 1.0
constant: false

metaR r2130
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185

metaM tststerone c
is: HMDB00234
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
name: testosterone
is: CHEBI:17347
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
constant: false

metaM HC02206 c
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: prostaglandin C1(1-)
initial concentration: 1.0
is: CHEBI:57399
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
type: Species
constant: false
has only substance units: false

metaR r0830
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
reversible: true
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaM val L c
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00883
is: CHEBI:16414
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
constant: false
type: Species
initial concentration: 1.0
name: L-valine
initial amount: NaN

metaR EX gltcho LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for beta glucan-taurocholic acid complex
type: Reaction

metaM 34dhoxmand c
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: HMDB01866
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: 3,4-Dihydroxymandelate
is: CHEBI:27637
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_ed7e911b_3bd2_43b7_a954_a4c638406aa3
is: P12235
constant: false
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: SLC25A4
is encoded by: hsa:291
initial amount: NaN

metaR r1620
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_faa1eb27_7eed_429e_9254_c495a01c161d
has only substance units: false
type: Species
name: HADH
initial amount: NaN
is encoded by: hsa:3033
is: Q16836
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR r0033
product: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.6.1.5
modifier: MODEL1310110005#
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:

metaR CYTDt
is described by: ECO:0000269
fast: false
name: cytidine facilated transport in cytosol
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
type: Reaction
modifier: MODEL1310110005#
is: SBO:0000185
reversible: true
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_fccba6b4_35a9_47ca_ab5b_c032ba6649d1
name: _U37519_1_m
constant: false
initial amount: NaN
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:U37519

metaM nh4 n
boundary condition: false
name: ammonium
is: SBO:0000247
type: Species
constant: false
is: CHEBI:28938
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
initial concentration: 1.0
is: HMDB00051

metaR SUCOAS1m
name: Succinate--CoA ligase (GDP-forming)
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
modifier: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reversible: true
product: MODEL1310110005#
is: SBO:0000176

metaM thbpt4acam n
is: HMDB02281
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: CHEBI:15374
constant: false
name: 4a-hydroxytetrahydrobiopterin

metaR r0835
is version of: http://identifiers.org/ec-code/3.5.4.16
reversible: true
type: Reaction
is: SBO:0000185
modifier: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2

http://identifiers.org/biomodels.db/MODEL1310110005#_8f29d9e4_bbe6_4428_83dd_b698ccdf1202
name: NDUFV2
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: P19404
type: Species
is encoded by: hsa:4729
boundary condition: true
initial concentration: NaN

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaM chlstol r
initial amount: NaN
is: CHEBI:16290
name: 5alpha-cholesta-7,24-dien-3beta-ol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
type: Species
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB06842

metaM L2aadp c
initial concentration: 1.0
is: HMDB00510
is: CHEBI:58672
constant: false
is: SBO:0000247
name: L-2-aminoadipate(1-)
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956

metaR r1625
is: SBO:0000185
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110005#
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaM crm hs e
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false
constant: false
is: CHEBI:52639
initial concentration: 1.0
name: N-acylsphingosine
is: SBO:0000247

metaR BTNt2
fast: false
product: MODEL1310110005#
name: Biotin reversible transport via proton symport
reversible: true
modifier: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD

metaM udp c
is: HMDB00295
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: C00015
is: CHEBI:58223
constant: false
name: UDP
boundary condition: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015

metaM 2obut c
name: 2-Oxobutanoate
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00005
is: CHEBI:16763
constant: false
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
boundary condition: false
is: C00109
initial amount: NaN

metaM ca2 e
is: SBO:0000247
is: HMDB00464
initial amount: NaN
boundary condition: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial concentration: 1.0
type: Species
is: CHEBI:29108
constant: false
has only substance units: false
name: calcium(2+)

metaR RETNt
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
is: SBO:0000185
is described by: ECO:0000000
name: retinoic acid transport
product: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_d825ac6d_ec15_461d_8e17_de72d5958746
name: PTGIS
boundary condition: true
has only substance units: false
is: Q16647
is encoded by: hsa:5740
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_8bb3e19f_96d4_4847_bc15_786e06c86806
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
name: _AA278423_1_c
initial amount: NaN
boundary condition: true
is encoded by: hsa:AA278423

metaR r0836
reactant: MODEL1310110005#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
type: Reaction

metaM didp c
is: SBO:0000247
type: Species
initial amount: NaN
name: dIDP
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
constant: false
boundary condition: false
is: CHEBI:28823
has only substance units: false
is: HMDB03536
initial concentration: 1.0

metaR SCP22x
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.176
reactant: MODEL1310110005#
name: Sterol carrier protein 2
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
kinetic law: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110005#
fast: false

metaM inost e
is: HMDB00211
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:17268
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: myo-inositol
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137

metaR LEUKTRF4t
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000000
name: leukotriene F4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR r1626
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110005#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_dfb0250f_1cb0_403a_af9f_13c131e041d5
initial amount: NaN
name: PRDX2
initial concentration: NaN
is encoded by: hsa:7001
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P32119
type: Species

metaR RE3000M
reactant: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000176
type: Reaction
name: RE3000
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110005#
modifier: MODEL1310110005#

metaR RE2541E
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
type: Reaction
kinetic law: MODEL1310110005#
is described by: ECO:0000000
fast: false
name: RE2541
reactant: MODEL1310110005#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.31
is: SBO:0000176
product: MODEL1310110005#
modifier: MODEL1310110005#

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR RE1533M
fast: false
modifier: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
name: RE1533
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110005#

metaM CE2418 m
boundary condition: false
initial concentration: 1.0
constant: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
is: CHEBI:28387
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
is: HMDB11123

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaM val L e
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: CHEBI:16414
name: L-valine
is: HMDB00883
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_b806dbc2_a804_4adf_8a56_41a5c02d91fa
constant: false
is: Q96NR8
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:145226
type: Species
initial amount: NaN
name: RDH12
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_811ab495_d3a3_46bc_b94d_4bad80cb1a1f
is encoded by: hsa:217
initial concentration: NaN
name: ALDH2
is: SBO:0000252
boundary condition: true
constant: false
is: P05091
has only substance units: false
initial amount: NaN
type: Species

metaR BHBt
kinetic law: MODEL1310110005#
name: (R)-3-Hydroxybutanoate transport via H+ symport
product: MODEL1310110005#
reversible: true
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
reactant: MODEL1310110005#

metaM ppi c
notes: FORMULA: HO7P2 CHARGE: -3
has only substance units: false
name: Diphosphate
constant: false
type: Species
initial concentration: 1.0
is: C00013
boundary condition: false
is: CHEBI:0
initial amount: NaN
is: HMDB00250
is: SBO:0000247

metaM 4mop c
is: CHEBI:17865
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: 4-methyl-2-oxopentanoate
is: HMDB00695
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233

http://identifiers.org/biomodels.db/MODEL1310110005#_6cc59f8a_1548_4e9b_96ce_2f9d63117c4b
name: ALDOA
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:226
has only substance units: false
initial concentration: NaN
type: Species

metaR r1623
reactant: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110005#
product: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true

metaM udp e
constant: false
initial concentration: 1.0
is: CHEBI:58223
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
name: UDP(3-)
initial amount: NaN
has only substance units: false

metaM c226crn m
boundary condition: false
initial amount: NaN
name: cervonyl carnitine
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB06510
type: Species
is: http://identifiers.org/pubchem.compound/127055
constant: false

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaR 5MTHFt
reactant: MODEL1310110005#
fast: false
product: MODEL1310110005#
is described by: ECO:0000269
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
type: Reaction
reversible: true
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT

metaM 3hmbcoa m
is: HMDB01356
initial amount: NaN
has only substance units: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: CHEBI:57312
type: Species
constant: false
is: SBO:0000247
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
boundary condition: false
initial concentration: 1.0

metaM 1pyr5c c
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01301
boundary condition: false
name: 1-Pyrroline-5-carboxylate
is: CHEBI:15893
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
constant: false
type: Species
is: C03912

metaR DMNONCOACRNCPT1
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DMNONCOACRNCPT1

http://identifiers.org/biomodels.db/MODEL1310110005#_00a876f8_512a_4168_afd9_c04a0b519b71
initial concentration: NaN
is encoded by: hsa:3283
boundary condition: true
is: P14060
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: HSD3B1
is: SBO:0000252

metaM dcholcoa r
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
has only substance units: false
type: Species
boundary condition: false
constant: false
name: chenodeoxycholoyl coenzyme a
initial concentration: 1.0
initial amount: NaN
is: HMDB06292
is: SBO:0000247
is: CHEBI:28701

metaM inost c
initial concentration: 1.0
has only substance units: false
is: HMDB00211
constant: false
is: CHEBI:17268
type: Species
boundary condition: false
initial amount: NaN
name: myo-inositol
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
is: SBO:0000247

metaR INSTt4
reversible: true
type: Reaction
name: inositol transport via sodium symport
is: SBO:0000185
reactant: MODEL1310110005#
is described by: ECO:0000269
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
product: MODEL1310110005#
fast: false

metaR SLCBK1
fast: false
reactant: MODEL1310110005#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.91
type: Reaction
modifier: MODEL1310110005#
product: MODEL1310110005#
name: sphingolipid long chain base kinase (sphinganine)
is: SBO:0000176
kinetic law: MODEL1310110005#
reversible: false
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110005#_60a2bba9_22d9_44d1_bf63_8f06b7aa2ddd
constant: false
is encoded by: hsa:341947
initial concentration: NaN
boundary condition: true
name: COX8C
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is: Q7Z4L0

metaM hpyr c
type: Species
constant: false
name: 3-hydroxypyruvate
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
is: HMDB01352
is: CHEBI:17180
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_8603fc99_3317_433e_83b0_e5440fa60320
constant: false
is encoded by: hsa:18
name: ABAT
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_86cb95ea_45f4_48b8_a2a0_7d622f23870b
is: Q8N4Q0
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:284273
boundary condition: true
name: ZADH2
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM 3aib D m
initial amount: NaN
is: SBO:0000247
name: D-3-Amino-isobutanoate
is: HMDB02299
initial concentration: 1.0
is: C03265
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
has only substance units: false
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_9c849abc_1c7e_48ce_8f6f_37ddd183f958
has only substance units: false
is: SBO:0000252
name: RHBG
is: Q9H310
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:57127
type: Species

metaR r1624
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110005#
product: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110005#
modifier: MODEL1310110005#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_5c3076d1_37c2_4a57_bc4b_569dfd9ab538
initial concentration: NaN
name: AK3
is: SBO:0000252
type: Species
is: E7ET30
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:50808

metaR r0584
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
kinetic law: MODEL1310110005#
reversible: true
reactant: MODEL1310110005#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
type: Reaction
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_e18ba7b6_4b35_454a_b60d_8f27bef018c0
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
name: _AI091231_1_c
is encoded by: hsa:AI091231
has only substance units: false
constant: false
boundary condition: true

metaM dcholcoa x
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: CHEBI:28701
name: chenodeoxycholoyl coenzyme a
initial amount: NaN
has only substance units: false
is: HMDB06292
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: SBO:0000247

metaR GLYt7 211 r
name: glycine reversible transport via sodium and chloride symport (2:1:1)
fast: false
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000269
reactant: MODEL1310110005#
type: Reaction
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110005#_03773b8f_9b78_4d67_9c8d_1c616622561b
name: SLC26A1
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10861
is: Q9H2B4
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN

metaM thf m
is: CHEBI:57453
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C00101
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
constant: false
is: HMDB01846
name: 5,6,7,8-Tetrahydrofolate
has only substance units: false
type: Species
boundary condition: false

metaR ASPt6
name: L-aspartate transport via Na, H symport and K antiport
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003
product: MODEL1310110005#
reversible: false
modifier: MODEL1310110005#

metaM CE2424 m
constant: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
has only substance units: false
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
is: HMDB11123
is: SBO:0000247
is: CHEBI:28387
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaM 5adtststerones e
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
is: HMDB06278
type: Species

metaM pail5p hs n
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:57795
type: Species
constant: false

metaM g6p c
is: C00092
is: HMDB01401
name: D-Glucose 6-phosphate
boundary condition: false
initial amount: NaN
is: CHEBI:61548
is: SBO:0000247
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
constant: false
has only substance units: false
initial concentration: 1.0

metaR r1618
type: Reaction
modifier: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110005#

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaM na1 r
constant: false
is: CHEBI:29101
initial amount: NaN
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
has only substance units: false
is: SBO:0000247
is: HMDB00588
initial concentration: 1.0
type: Species
boundary condition: false
name: sodium(1+)

http://identifiers.org/biomodels.db/MODEL1310110005#_b1eead42_c8d9_4723_ac10_bf38986172fd
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:56901
type: Species
initial concentration: NaN
is: Q9NRX3
constant: false
has only substance units: false
boundary condition: true
name: NDUFA4L2

metaR GULNDer
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
name: gulonate dehydrogenase, endoplasmic reticulum
reversible: true
product: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#

metaR r1617
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_39ee6059_4e00_4634_b710_3a2e247eec96
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:84076
name: TKTL2
is: Q9H0I9
type: Species

metaM o2s m
is: HMDB02168
type: Species
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
initial concentration: 1.0
name: Superoxide anion
constant: false
boundary condition: false
is: C00704
is: SBO:0000247
has only substance units: false
is: CHEBI:18421

metaR r0714
is: SBO:0000176
reversible: false
reactant: MODEL1310110005#
is described by: ECO:0000000
product: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110005#_4a265846_ea22_426f_8851_22a3b63e4102
is encoded by: hsa:2882
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is: Q96SL4
has only substance units: false
boundary condition: true
constant: false
name: GPX7

http://identifiers.org/biomodels.db/MODEL1310110005#_95f6f1ad_6fdd_4ece_8d13_9ed8a6c03fcb
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:3158
name: HMGCS2
initial concentration: NaN
type: Species
is: P54868

metaM utp n
has only substance units: false
name: UTP(4-)
initial amount: NaN
is: CHEBI:46398
is: HMDB00285
type: Species
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR r0580
reactant: MODEL1310110005#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
product: MODEL1310110005#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.99.7

metaM stcoa c
type: Species
boundary condition: false
is: HMDB01114
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
name: Stearoyl-CoA (n-C18:0CoA)
initial amount: NaN
is: SBO:0000247
is: CHEBI:57394
initial concentration: 1.0
has only substance units: false
constant: false
is: C00412

metaM 5adtststerones c
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
constant: false
is: SBO:0000247
initial amount: NaN
name: 5alpha-Dihydrotestosterone sulfate
is: HMDB06278
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_36e732b3_ff1b_47b4_b897_0bf55cd5dca1
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: _AI935189_1_m
has only substance units: false
boundary condition: true
is encoded by: hsa:AI935189

http://identifiers.org/biomodels.db/MODEL1310110005#_baec60ab_752d_4eb3_b301_e14a621d7f64
initial amount: NaN
name: NME6
initial concentration: NaN
has only substance units: false
is: O75414
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:10201
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_d4648f6b_5ccc_4d31_92ed_613799552572
name: _LOC727762_1_m
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:LOC727762
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_0379a7a0_a07a_44ab_a045_b66b81955d85
is: O95498
name: VNN2
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:8875
constant: false
has only substance units: false
boundary condition: true

metaR r1616
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110005#
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110005#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_440dd221_96e6_4249_ac1d_d69aec285761
boundary condition: true
is encoded by: hsa:6715
name: SRD5A1
has only substance units: false
is: P18405
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaR RE3001M
is described by: ECO:0000000
reversible: true
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE3001
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.3.1.34
is: SBO:0000176
type: Reaction

metaR PIter
reversible: true
kinetic law: MODEL1310110005#
is described by: ECO:0000212
is: SBO:0000185
product: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
name: phosphate transport, endoplasmic reticulum
fast: false
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110005#_01240a74_79fd_4437_92ce_6102ca339f56
boundary condition: true
name: IDH2
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3418
is: P48735

http://identifiers.org/biomodels.db/MODEL1310110005#_34f4d05a_4e14_4f1a_9d51_418f727c8bcd
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:10327
initial amount: NaN
name: AKR1A1
is: SBO:0000252
boundary condition: true
type: Species
is: P14550

metaM dopa c
boundary condition: false
type: Species
name: dopaminium(1+)
is: CHEBI:59905
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: HMDB00073

http://identifiers.org/biomodels.db/MODEL1310110005#_fa6e2d8a_5541_4a62_885e_782ba66ecd33
name: SLCO1A2
initial amount: NaN
initial concentration: NaN
is: P46721
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:6579
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_557a25c8_2461_4b17_924d_c7abaaddc0ab
type: Species
initial amount: NaN
name: _AU149534_1_c
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AU149534
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_ed367a4f_e587_4657_a41b_3bef4177d07a
has only substance units: false
initial concentration: NaN
name: _AL525798_1_c
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:AL525798

metaM acnam n
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:35418
initial concentration: 1.0
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial amount: NaN
boundary condition: false
is: HMDB00230
name: N-acetylneuraminate
type: Species

metaM fdp c
name: D-Fructose 1,6-bisphosphate
is: http://identifiers.org/pubchem.compound/3647
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
initial concentration: 1.0
is: C00354
is: CHEBI:16905
has only substance units: false
type: Species
is: HMDB01058
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false

metaR r1401
is: SBO:0000185
type: Reaction
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.51
modifier: MODEL1310110005#
reactant: MODEL1310110005#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/2.7.10.1
is version of: http://identifiers.org/ec-code/3.2.1.35
fast: false
kinetic law: MODEL1310110005#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.41
is version of: http://identifiers.org/ec-code/3.1.1.3

metaM glyc3p x
is: HMDB00126
initial amount: NaN
has only substance units: false
is: CHEBI:57597
boundary condition: false
is: C00093
initial concentration: 1.0
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
constant: false
is: SBO:0000247
name: Glycerol 3-phosphate
type: Species

metaR SR5ARr
product: MODEL1310110005#
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.5
type: Reaction
fast: false
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
is described by: ECO:0000134
is: SBO:0000176
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_df63aff4_301f_41d4_9721_87a51248fa98
constant: false
is encoded by: hsa:AI222095
initial concentration: NaN
name: _AI222095_1_e
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_afe1bc0a_6ebc_4ff5_8871_e1964c17eb8a
has only substance units: false
constant: false
is encoded by: hsa:BE042354
initial amount: NaN
boundary condition: true
type: Species
name: _BE042354_1_m
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_b3e6e6ce_9917_4351_9ac2_4d3a8e55444b
is: SBO:0000252
constant: false
name: _H53099_1_m
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:H53099
boundary condition: true
has only substance units: false

metaR TSTSTERONEt
kinetic law: MODEL1310110005#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110005#
reversible: true
name: Testosterone transport
product: MODEL1310110005#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_fb83a043_5002_4faa_a378_39db9da85f5d
constant: false
is encoded by: hsa:54
initial amount: NaN
initial concentration: NaN
type: Species
is: P13686
boundary condition: true
is: SBO:0000252
name: ACP5
has only substance units: false

metaR r1615
type: Reaction
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110005#
fast: false
product: MODEL1310110005#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_636dafc2_69f1_4eb4_a737_11b1aa4b48cd
boundary condition: true
name: FOLR1
has only substance units: false
is encoded by: hsa:2348
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_b01574d1_a30b_472d_9911_51feebbdf3e4
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
name: CYP27A1
has only substance units: false
is encoded by: hsa:1593
initial concentration: NaN
is: Q02318

http://identifiers.org/biomodels.db/MODEL1310110005#_0303638c_df82_44d7_96a7_7f46ad7a22b0
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: ACAD11
is: Q709F0
boundary condition: true
is encoded by: hsa:84129

metaM CE2838 e
is: http://identifiers.org/pubchem.compound/5041
constant: false
is: SBO:0000247
name: maltononaose
has only substance units: false
initial concentration: 1.0
is: C01936
initial amount: NaN
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
type: Species
boundary condition: false

metaR TDCHOLAte
name: bile acid intracellular transport
fast: false
reversible: true
product: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is described by: ECO:0000000
kinetic law: MODEL1310110005#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_05d4fc7c_4d4e_44c9_9992_2ab3970188a3
boundary condition: true
is encoded by: hsa:26266
is: Q9UKG4
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
name: SLC13A4
type: Species

metaR SRTNtu
fast: false
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
kinetic law: MODEL1310110005#
reversible: true
type: Reaction
is described by: ECO:0000269
name: Serotonin uniport
modifier: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_4cc0e090_7c9c_4953_a7e1_1c34878bc2af
has only substance units: false
constant: false
boundary condition: true
name: _AI191472_1_c
type: Species
is encoded by: hsa:AI191472
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR SERDGLYexR
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: D-Serine/Glycine reversible exchange
product: MODEL1310110005#
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
is: SBO:0000185
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_c5e13aa3_e2f7_4beb_8df3_e4f0883be70e
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6241
boundary condition: true
is: SBO:0000252
name: RRM2
has only substance units: false
type: Species
is: P31350
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_f6e04e2a_b1d5_45b4_9172_0558fa233dd5
constant: false
initial concentration: NaN
name: NMNAT2
initial amount: NaN
is: SBO:0000252
boundary condition: true
is: Q9BZQ4
type: Species
has only substance units: false
is encoded by: hsa:23057

metaM tststerone e
has only substance units: false
constant: false
is: CHEBI:17347
initial amount: NaN
is: SBO:0000247
is: HMDB00234
boundary condition: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
name: testosterone
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_be7dbb75_6d7d_4be5_8aa5_41e0eb7cca6f
is: P19440
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: GGT1
is encoded by: hsa:2678

metaM lnlccoa c
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
name: linoleic coenzyme A
initial concentration: 1.0
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5462164
is: HMDB01064

metaR CO2tm
reactant: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
product: MODEL1310110005#
name: CO2 transport (diffusion), mitochondrial
fast: false
kinetic law: MODEL1310110005#
reversible: true
is: SBO:0000185

metaM pail45p hs n
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: phosphatidylinositol 4,5-bisphosphate
constant: false
is: CHEBI:28910
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637

metaM clpndcoa x
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
initial concentration: 1.0
is: SBO:0000247
is: HMDB06267
is: C16166
has only substance units: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205476
constant: false
type: Species
initial amount: NaN
name: clupanodonyl CoA

http://identifiers.org/biomodels.db/MODEL1310110005#_19f88314_1a98_4e1e_bf9b_c8a39ad58111
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is: P17812
type: Species
is encoded by: hsa:1503
initial amount: NaN
name: CTPS1

MODEL1310110005
species: metaM CE2424 m
species: metaM kynate c
reaction: metaR CO2tm
species: metaM r1p c
species: metaM bilglcur c
species: metaM ala L e
reaction: metaR ALAtN1
species: metaM Sfglutth c
reaction: metaR TCHOLAte
reaction: metaR KHte
reaction: metaR r1862
reaction: metaR r0408
species: metaM o2 x
reaction: metaR EX prostge2 LPAREN e RPAREN
species: metaM na1 e
species: metaM asp L e
reaction: metaR RE3628M
species: metaM HC01603 c
reaction: metaR O2tm
species: metaM dttp n
species: metaM h2o e
species: metaM h2o2 n
species: metaM anth c
reaction: metaR BAAT2x
species: metaM L2aadp c
reaction: metaR ARACHCRNt
species: metaM HC01406 m
species: metaM lald D c
species: metaM txa2 e
reaction: metaR GLYBt4 2 r
species: metaM thf c
reaction: metaR r1018
reaction: metaR r0683
reaction: metaR ADK3m
reaction: metaR r2101
species: metaM tcynt c
reaction: metaR VALt5m
reaction: metaR GK1
reaction: metaR FRDPtc
species: metaM CE4876 r
reaction: metaR r2079
species: metaM ser D e
reaction: metaR 5ADTSTSTERONEtr
reaction: metaR r1547
species: metaM xol7aone c
reaction: metaR TDCHOLAte
reaction: metaR r1877
reaction: metaR r0391
reaction: metaR DNDPt16m
reaction: metaR r2142
is derived from: MODEL1109130000
species: metaM leu L c
reaction: metaR r2121
reaction: metaR RE1796M
reaction: metaR RE1533M
reaction: metaR RNMK
species: metaM ac m
species: metaM c4crn c
reaction: metaR r1562
species: metaM leuktrE4 e
reaction: metaR GTHP
species: metaM atp m
reaction: metaR EX dtdp LPAREN e RPAREN
reaction: metaR EX C04849 LPAREN e RPAREN
species: metaM leu L m
reaction: metaR r0386
reaction: metaR r2329
reaction: metaR PI4P5Kn
reaction: metaR r0280
reaction: metaR r1584
species: metaM HC02216 c
species: metaM CE5854 e
reaction: metaR r0885
species: metaM dcamp c
reaction: metaR DUTPDPn
species: metaM CE5786 e
reaction: metaR MANt4
species: metaM orn e
species: metaM val L c
reaction: metaR FAOXC226205m

metaR UMPK5n
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reactant: MODEL1310110005#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000176
name: UMP kinase (dATP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR 3MOPt2im
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
type: Reaction

metaR 34DHXMANDACOX NADP
modifier: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
reactant: MODEL1310110005#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
fast: false
is: SBO:0000176
product: MODEL1310110005#
reversible: true
is described by: ECO:0000269

metaM dopa e
initial amount: NaN
is: CHEBI:59905
boundary condition: false
constant: false
name: dopaminium(1+)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: HMDB00073
type: Species
has only substance units: false

metaR r1318
name: Transport reaction
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110005#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_34b3398d_8fd7_4d35_a4df_513307069e74
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR CYTK13n
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reactant: MODEL1310110005#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dATP),nuclear

metaR TREHe
is: SBO:0000176
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
product: MODEL1310110005#
reversible: false
is described by: ECO:0000269
fast: false
modifier: MODEL1310110005#
name: alpha,alpha-trehalase
is version of: http://identifiers.org/ec-code/3.2.1.28
type: Reaction
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#

metaM pail45p hs m
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
name: phosphatidylinositol 4,5-bisphosphate
is: SBO:0000247
is: CHEBI:28910
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
constant: false
boundary condition: false

metaR H2Oter
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000185
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
name: H2O endoplasmic reticulum transport
is described by: ECO:0000000

metaM retinol c
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
initial concentration: 1.0
is: HMDB00305
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:50211
name: retinol

metaM atp m
is: C00002
is: CHEBI:57299
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false
is: HMDB00538
name: ATP(4-)
initial concentration: 1.0
initial amount: NaN

metaM cgly e
is: HMDB00078
initial amount: NaN
is: CHEBI:4047
has only substance units: false
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
name: L-cysteinylglycine
is: SBO:0000247
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419

metaR r1493
name: Utilized transport
reversible: false
kinetic law: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
fast: false
is: SBO:0000185
type: Reaction
product: MODEL1310110005#
reactant: MODEL1310110005#

metaM o2s n
is: HMDB02168
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
name: superoxide
is: CHEBI:18421

metaM dcdp c
constant: false
is: CHEBI:58593
is: HMDB01245
initial concentration: 1.0
name: dCDP
is: C00705
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
has only substance units: false

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_a50cc72d_3b0e_46ec_b9d9_8736e35e589b
is: P30084
initial amount: NaN
type: Species
name: ECHS1
boundary condition: true
is encoded by: hsa:1892
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_a286c48f_d11b_4ee1_b1b9_0150378bbed9
type: Species
name: TM7SF2
is: O76062
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7108
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_5cddf7ef_1257_4cfe_bdc7_f51fcd769120
name: ELOVL4
initial amount: NaN
is encoded by: hsa:6785
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q9GZR5
constant: false
has only substance units: false
type: Species

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR TXA2te
type: Reaction
name: thromboxane A2 transport
is: SBO:0000185
kinetic law: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ
is described by: ECO:0000000
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_abeb4b97_6da0_4195_a946_107557654c56
name: NT5C1B
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:93034
initial concentration: NaN
has only substance units: false
constant: false
is: B3KUK6
is: SBO:0000252

metaR C204CRNt
is described by: ECO:0000000
reversible: false
name: arachidonic acid transport into the mitochondria
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000185
product: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
reactant: MODEL1310110005#

metaR r1619
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110005#
product: MODEL1310110005#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_ee268fb9_ca8e_47b9_bf54_b2d25a49dfb4
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: DPYD
has only substance units: false
is: Q12882
is encoded by: hsa:1806
type: Species
is: SBO:0000252

metaM thbpt4acam c
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15374
is: HMDB02281
name: 4a-hydroxytetrahydrobiopterin
type: Species

metaM galside hs e
is: CHEBI:12947
has only substance units: false
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
constant: false
initial concentration: 1.0
type: Species
boundary condition: false

metaR PMTCOAtx
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
type: Reaction
name: fatty acid intracellular transport
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110005#

metaR r2347
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaM tststerone r
is: SBO:0000247
constant: false
is: HMDB00234
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
has only substance units: false
is: CHEBI:17347
name: testosterone
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_3443ba3e_99df_4fbf_b8e6_90687766db43
constant: false
has only substance units: false
initial concentration: NaN
is: Q9NS82
is encoded by: hsa:56301
initial amount: NaN
is: SBO:0000252
name: SLC7A10
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_eb3622e6_15ce_45dc_b8d3_28f6e217f068
type: Species
initial concentration: NaN
name: FOLR1
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2348
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_ac0f9ed9_143d_4d3e_9d84_f51c59a4cec8
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
name: DUT
is encoded by: hsa:1854
is: P33316

metaM cgly c
name: L-cysteinylglycine
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
initial concentration: 1.0
is: CHEBI:4047
has only substance units: false
is: HMDB00078
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM dcdp n
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: SBO:0000247
is: CHEBI:58593
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01245
constant: false
name: dCDP(3-)
has only substance units: false

metaM ru5p D c
initial concentration: 1.0
name: D-ribulose 5-phosphate(2-)
initial amount: NaN
is: HMDB00618
boundary condition: false
is: CHEBI:58121
is: SBO:0000247
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
has only substance units: false
type: Species

metaM tre e
is: HMDB00975
is: CHEBI:16551
is: SBO:0000247
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
has only substance units: false
is: C01083
name: Trehalose
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
boundary condition: false

metaM bilirub c
has only substance units: false
is: HMDB00054
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
name: bilirubin(2-)
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial amount: NaN
boundary condition: false
is: CHEBI:57977

metaM 13 cis retn r
is: http://identifiers.org/pubchem.compound/7847414
is: D00348
has only substance units: false
boundary condition: false
name: 13-cis-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: SBO:0000247
constant: false
is: HMDB06219
type: Species
initial amount: NaN
initial concentration: 1.0

metaR TMDS
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: false
is version of: http://identifiers.org/ec-code/2.1.1.45
notes: GENE_ASSOCIATION: (7298.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.1.1.45 Confidence Level: 4 AUTHORS: PMID:14967037,PMID:2243092 NOTES:
name: thymidylate synthase
reactant: MODEL1310110005#
fast: false
product: MODEL1310110005#
type: Reaction

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaM HC01223 m
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
initial amount: NaN
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
is: SBO:0000247
is: CHEBI:57340
type: Species

metaR r2346
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
kinetic law: MODEL1310110005#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110005#
reactant: MODEL1310110005#

metaM o2s e
boundary condition: false
has only substance units: false
is: CHEBI:18421
is: HMDB02168
type: Species
name: superoxide
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704

metaR CYTK2n
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110005#
fast: false
name: cytidylate kinase (dCMP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000176
product: MODEL1310110005#
is described by: ECO:0000269
type: Reaction

metaM utp c
initial amount: NaN
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false
name: UTP
is: C00075
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:46398
boundary condition: false
constant: false
is: HMDB00285

metaR CLPNDCOAtx
is: SBO:0000185
product: MODEL1310110005#
is described by: ECO:0000000
fast: false
reversible: true
name: fatty acid intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#

metaR DESAT22 2p
product: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
fast: false
reversible: false
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)

metaR r1847
fast: false
reversible: false
product: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110005#_bac86674_0e5c_4216_839d_9d16221f08bf
is: SBO:0000252
is: Q9P0J0
constant: false
has only substance units: false
initial amount: NaN
name: NDUFA13
boundary condition: true
type: Species
is encoded by: hsa:51079
initial concentration: NaN

metaR r1492
product: MODEL1310110005#
is: SBO:0000185
fast: false
name: Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction

metaM dcdp m
name: dCDP(3-)
has only substance units: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: SBO:0000247
is: CHEBI:58593
initial amount: NaN
is: HMDB01245
type: Species
initial concentration: 1.0
constant: false
boundary condition: false

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

metaM atp n
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: ATP(3-)
initial concentration: 1.0
is: HMDB00538
boundary condition: false
type: Species
is: CHEBI:57299
constant: false

metaM pac c
type: Species
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:18401
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
is: HMDB00209
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: phenylacetate

http://identifiers.org/biomodels.db/MODEL1310110005#_594b59f9_d6a9_4fa0_9b5f_30525dd43099
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:2876
is: SBO:0000252
constant: false
is: P07203
name: GPX1

metaR r0149
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
type: Reaction
product: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
modifier: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.14.13.39

metaR EX 3ump LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3'-UMP(2-) exchange
type: Reaction

metaR TRDR
is described by: ECO:0000269
modifier: MODEL1310110005#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
reversible: false
name: thioredoxin reductase (NADPH)
is version of: http://identifiers.org/ec-code/1.8.1.9

metaM atp r
name: ATP(4-)
initial concentration: 1.0
is: CHEBI:57299
is: HMDB00538
has only substance units: false
constant: false
type: Species
is: SBO:0000247
is: C00002
initial amount: NaN
boundary condition: false

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaM CE0849 m
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
name: cis,cis-palmito-7,10-dienoyl-CoA
has only substance units: false
is: CHEBI:57795

metaR THP2Ctp
type: Reaction
is described by: ECO:0000000
fast: false
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
kinetic law: MODEL1310110005#
is: SBO:0000185
reversible: true
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_8b9ae34d_44a2_4d32_8f9f_acabaee96ddc
initial concentration: NaN
type: Species
is: SBO:0000252
name: ALAS1
has only substance units: false
is encoded by: hsa:211
constant: false
is: Q5JAM2
initial amount: NaN
boundary condition: true

metaM bilirub e
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: HMDB00054
name: bilirubin(2-)
is: CHEBI:57977

http://identifiers.org/biomodels.db/MODEL1310110005#_94cbc510_1551_4362_8d99_f05afb9b9870
boundary condition: true
name: LDHC
is encoded by: hsa:3948
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR MTHFR3
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (4524.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES:absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.
reactant: MODEL1310110005#
is: SBO:0000176
fast: false
type: Reaction
reversible: false
is described by: ECO:0000134
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
name: 5,10-methylenetetrahydrofolatereductase (NADPH)
is version of: http://identifiers.org/ec-code/1.5.1.20

metaM 13dpg c
has only substance units: false
initial concentration: 1.0
name: 3-Phospho-D-glyceroyl phosphate
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3535
is: CHEBI:57604
is: HMDB01270
is: SBO:0000247
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
boundary condition: false
is: C00236
constant: false
type: Species

metaM o2s c
has only substance units: false
boundary condition: false
name: superoxide
type: Species
is: CHEBI:18421
is: HMDB02168
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_bca75b44_f55c_48f7_ae12_f56753793558
initial concentration: NaN
name: RPE
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is: Q96AT9
is encoded by: hsa:6120
constant: false
initial amount: NaN

metaR r2344
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport

metaR XYLTt
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
name: Xylitol transport via passive diffusion
is: SBO:0000185
fast: false
product: MODEL1310110005#

metaM r5p c
has only substance units: false
is: CHEBI:18189
initial amount: NaN
is: SBO:0000247
is: C00117
name: alpha-D-Ribose 5-phosphate
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117

http://identifiers.org/biomodels.db/MODEL1310110005#_16a86898_6e2f_46aa_9085_b572b5ac0161
is: SBO:0000252
is: P07451
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
name: CA3
is encoded by: hsa:761
initial concentration: NaN
constant: false

metaM utp e
type: Species
constant: false
is: HMDB00285
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
name: UTP(4-)
boundary condition: false
is: CHEBI:46398
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM ppi x
initial amount: NaN
boundary condition: false
is: C00013
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
constant: false
name: Diphosphate
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00250
is: CHEBI:33019
is: SBO:0000247

metaR THRGLYexR
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110005#
type: Reaction
is described by: ECO:0000304
name: L-threonine/glycine reversible exchange
reversible: true
is: SBO:0000185
modifier: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_22c1c141_9929_4143_bace_534ce5228871
initial concentration: NaN
name: SLC12A6
has only substance units: false
is: Q9UHW9
boundary condition: true
type: Species
is encoded by: hsa:9990
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_e45ab86c_2e77_43a3_ab02_de80a9dc616f
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: Q9NPH0
has only substance units: false
name: ACP6
initial concentration: NaN
is encoded by: hsa:51205
is: SBO:0000252

metaR r0994
type: Reaction
is: SBO:0000185
name: Facilitated diffusion
fast: false
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reversible: true

metaM amet c
initial concentration: 1.0
has only substance units: false
is: HMDB01185
boundary condition: false
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: CHEBI:15414
type: Species
is: C00019
is: SBO:0000247
name: S-Adenosyl-L-methionine
constant: false

metaR ARGtm
kinetic law: MODEL1310110005#
product: MODEL1310110005#
name: arginine mitochondrial transport via ornithine carrier
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110005#
reversible: true
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_62f5bc20_fa31_4272_8d84_10952c1482f0
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: COX1
is: Q7GXY8
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:4512

http://identifiers.org/biomodels.db/MODEL1310110005#_e781d51f_d881_489f_8ab5_2871757c4f78
boundary condition: true
initial concentration: NaN
is: Q3I5F7
initial amount: NaN
type: Species
is encoded by: hsa:641372
constant: false
is: SBO:0000252
has only substance units: false
name: ACOT6

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR r1400
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
type: Reaction
reversible: false
is: SBO:0000185

metaR 34DHXMANDACOX
reactant: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
fast: false
product: MODEL1310110005#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
modifier: MODEL1310110005#
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110005#

metaR NDPK5n
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110005#
type: Reaction
fast: false
is described by: ECO:0000304
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
reversible: true

metaM maltttr e
constant: false
is: C02052
name: Maltotetraose
boundary condition: false
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: http://identifiers.org/pubchem.compound/5141
initial concentration: 1.0
is: HMDB01296
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR CRNt
is: SBO:0000185
product: MODEL1310110005#
type: Reaction
name: L-carnitine reversible transport
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
is described by: ECO:0000269
reactant: MODEL1310110005#
reversible: true
fast: false
kinetic law: MODEL1310110005#

metaR MECOALm
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
reversible: true
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is described by: ECO:0000212
fast: false
kinetic law: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
modifier: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/6.2.1.5
product: MODEL1310110005#

metaR r0718
fast: false
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.181
is described by: ECO:0000000
type: Reaction
product: MODEL1310110005#
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: false
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#

metaR RE1342C
reactant: MODEL1310110005#
type: Reaction
reversible: true
name: RE1342
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
product: MODEL1310110005#
kinetic law: MODEL1310110005#

metaR HISTAtu
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
name: Histamine uniport
fast: false
type: Reaction
kinetic law: MODEL1310110005#
is: SBO:0000185
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_6d6eeda9_089e_450c_bed6_3184483b8e8c
is: P43007
constant: false
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:6509
initial concentration: NaN
is: SBO:0000252
name: SLC1A4

metaR RE1709C
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000176
name: RE1709
kinetic law: MODEL1310110005#

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaM HC01412 m
boundary condition: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:61405
name: trans-tetradec-2-enoyl-CoA(4-)
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM na1 e
boundary condition: false
notes: FORMULA: Na CHARGE: 1
initial concentration: 1.0
is: HMDB00588
has only substance units: false
is: CHEBI:4541
type: Species
name: Sodium
is: SBO:0000247
is: C01330
constant: false
initial amount: NaN

metaM 2dr1p c
is: C00672
boundary condition: false
name: 2-Deoxy-D-ribose 1-phosphate
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01351
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
is: CHEBI:58576

http://identifiers.org/biomodels.db/MODEL1310110005#_dc0aec9e_38f0_41b8_b289_7183d7ebbeb5
type: Species
constant: false
name: _X63359_1_c
has only substance units: false
boundary condition: true
is encoded by: hsa:X63359
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR PGPP hs
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.3.27 Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:
fast: false
product: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000176
name: Phosphatidylglycerol phosphate phosphatase (homo sapiens)
reversible: false
type: Reaction
kinetic law: MODEL1310110005#
is described by: ECO:0000000

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaM leuktrD4 c
is: SBO:0000247
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial amount: NaN
name: Leukotriene D4
is: CHEBI:28666
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
type: Species
is: HMDB03080

metaM leuktrC4 e
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
initial concentration: 1.0
name: leukotriene C4(2-)
is: CHEBI:57973
type: Species
has only substance units: false
is: HMDB01198

metaM ppi r
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
is: CHEBI:33019
name: Diphosphate
initial amount: NaN
is: C00013
boundary condition: false
constant: false
type: Species
has only substance units: false
is: HMDB00250
is: SBO:0000247

metaR r2341
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false

metaR r0604
reactant: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
modifier: MODEL1310110005#
is described by: ECO:0000000
fast: false
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
type: Reaction
reversible: false

metaR KHte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
product: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
name: KHte
is: SBO:0000185
kinetic law: MODEL1310110005#
type: Reaction
is described by: ECO:0000134

metaM HC01410 m
constant: false
boundary condition: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28706
has only substance units: false
is: SBO:0000247
type: Species
name: (2E)-Hexenoyl-CoA

metaM xolest2 hs e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17002
type: Species
constant: false
initial amount: NaN
name: cholesterol ester
has only substance units: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
boundary condition: false

metaR PROSTGF2t
is: SBO:0000185
reactant: MODEL1310110005#
is described by: ECO:0000269
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
modifier: MODEL1310110005#
fast: false
name: prostaglandin uniport
kinetic law: MODEL1310110005#
type: Reaction
reversible: true

metaR DASCBR
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
fast: false
type: Reaction
name: dehydroascorbate reductase
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.8.4.1
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110005#

metaM adp m
has only substance units: false
is: CHEBI:456216
is: HMDB01341
name: ADP
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3310
initial amount: NaN
boundary condition: false
is: C00008
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_57a1cc4f_c1c3_4664_af3f_6dcfbc2015d4
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AI926493
name: _AI926493_1_c
has only substance units: false
initial concentration: NaN
type: Species

metaM lnlccoa m
has only substance units: false
is: HMDB01064
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
initial concentration: 1.0
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
name: linoleic coenzyme A
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_ba7babad_6b61_405c_9ac6_924c1002ed78
constant: false
boundary condition: true
type: Species
is encoded by: hsa:AU149534
initial concentration: NaN
name: _AU149534_1_m
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR r0360
reactant: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.16
is: SBO:0000176
product: MODEL1310110005#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110005#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_d9644952_a458_4acc_b495_18156addc29f
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: _AV727634_1_c
is encoded by: hsa:AV727634

metaR r0603
fast: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.12
reactant: MODEL1310110005#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110005#
reversible: true
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12

metaM HC01672 c
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Acetyl adenylate
type: Species
boundary condition: false
notes: FORMULA: C12H15N5O8P CHARGE: -1 INCHI: InChI=1S/C12H16N5O8P/c1-5(18)25-26(21,22)23-2-6-8(19)9(20)12(24-6)17-4-16-7-10(13)14-3-15-11(7)17/h3-4,6,8-9,12,19-20H,2H2,1H3,(H,21,22)(H2,13,14,15)/t6-,8-,9-,12-/m1/s1 EHMN_ABBREVIATION: C05993
is: CHEBI:37666

metaM leuktrC4 c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: CHEBI:57973
type: Species
is: HMDB01198
boundary condition: false
is: SBO:0000247
name: leukotriene C4(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_adf1091b_fb8b_48c3_b17e_3f40d117c189
is encoded by: hsa:6005
initial concentration: NaN
name: RHAG
is: Q96E98
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false

metaM 4hpro LT m
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
is: HMDB00725
constant: false
initial amount: NaN
is: CHEBI:18095
has only substance units: false
name: trans-4-hydroxy-L-proline
is: SBO:0000247
type: Species

metaM adp n
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
initial amount: NaN
is: HMDB01341
constant: false
type: Species
name: ADP(3-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:456216
boundary condition: false

metaR r0716
fast: false
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
product: MODEL1310110005#
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110005#

metaM leuktrD4 e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
is: HMDB03080
is: SBO:0000247
is: CHEBI:28666
has only substance units: false
name: Leukotriene D4
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
constant: false

metaM pi x
name: hydrogenphosphate
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_d23a9502_d875_43a7_a679_e5a5944850d3
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:229
is: SBO:0000252
has only substance units: false
name: ALDOB
initial amount: NaN
is: P05062
type: Species

metaR r0472
is described by: ECO:0000000
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
fast: false
kinetic law: MODEL1310110005#
reversible: true
type: Reaction
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_fe18d396_21ae_4e32_8adf_8b5fa2906d9d
has only substance units: false
boundary condition: true
is encoded by: hsa:AI440329
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: _AI440329_1_r

http://identifiers.org/biomodels.db/MODEL1310110005#_8a0b144d_21c4_4b01_8a05_e1456170c0b9
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:54677
constant: false
type: Species
is: E7EQF2
has only substance units: false
initial amount: NaN
name: CROT

metaM sphgn c
name: sphinganine(1+)
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
constant: false
is: HMDB00269
initial concentration: 1.0
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
is: SBO:0000247
is: CHEBI:57817

metaR r0990
fast: false
name: Postulated transport reaction
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#

metaR r1599
reversible: true
reactant: MODEL1310110005#
fast: false
type: Reaction
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR GLNS
is described by: ECO:0000254
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.15
name: glutamine synthetase

metaM thym m
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
type: Species
boundary condition: false
is: CHEBI:17821
is: HMDB00262
is: SBO:0000247
name: thymine
has only substance units: false

metaR RE0691C
name: RE0691
reversible: true
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#

metaR LNLCCPT1
modifier: MODEL1310110005#
name: carnitine O-palmitoyltransferase
is: SBO:0000176
product: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110005#
is described by: ECO:0000269

metaM CE5121 m
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: CHEBI:57449
boundary condition: false
has only substance units: false
name: trans-3-decenoyl-CoA
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121

http://identifiers.org/biomodels.db/MODEL1310110005#_76375140_ad06_4871_a803_161aae397ad0
name: PCBD1
has only substance units: false
is encoded by: hsa:5092
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P61457
initial amount: NaN
constant: false
type: Species

metaM HC02207 c
type: Species
initial amount: NaN
is: CHEBI:27555
has only substance units: false
constant: false
name: prostaglandin-c2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR r0464
is: SBO:0000176
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: true
product: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
fast: false
is described by: ECO:0000000

metaR r2081
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
reversible: true
product: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR r2082
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
product: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR BAAT2x
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
reactant: MODEL1310110005#
name: bile acid Coenzyme A: amino acid N-acyltransferase
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000269
product: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaM nac c
boundary condition: false
initial concentration: 1.0
is: HMDB01488
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: C00253
is: SBO:0000247
name: Nicotinate
is: CHEBI:0
notes: FORMULA: C6H4NO2 CHARGE: -1

metaR Coqe
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
name: Transport of q10
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
product: MODEL1310110005#
fast: false

metaR LNLCt
reversible: true
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
kinetic law: MODEL1310110005#
is described by: ECO:0000000
fast: false
type: Reaction
name: Linoleic acid (n-C18:2) transport in via diffusion
reactant: MODEL1310110005#

metaM glyc S e
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
name: (S)-Glycerate
notes: FORMULA: C3H5O4 CHARGE: 0
is: HMDB06372
has only substance units: false
is: SBO:0000247
is: CHEBI:33871

metaR UMPKn
fast: false
modifier: MODEL1310110005#
type: Reaction
name: UMP kinase, nuclear
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
product: MODEL1310110005#

metaR ARACHCPT1
is described by: ECO:0000000
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
is: SBO:0000176
reversible: false
name: carnitine transferase
modifier: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
kinetic law: MODEL1310110005#

metaR r2114
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110005#
fast: false
product: MODEL1310110005#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110005#

metaR LNLCCPT2
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
is: SBO:0000176
reactant: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM lnlccoa r
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
type: Species
is: HMDB01064
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
name: linoleic coenzyme A
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: SBO:0000247

metaR ALADGLNexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110005#
type: Reaction
is: SBO:0000185
is described by: ECO:0000304
product: MODEL1310110005#
reversible: true
fast: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
name: L-alanine/glutamine reversible exchange

metaR r1598
is: SBO:0000185
reactant: MODEL1310110005#
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dttp c
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
type: Species
name: dTTP
is: CHEBI:37568
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C00459
initial amount: NaN
constant: false

metaR r2080
modifier: MODEL1310110005#
reactant: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110005#

metaR SUCCTD
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM asp D c
is: HMDB06483
constant: false
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: SBO:0000247
is: CHEBI:29990
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
name: D-aspartate(1-)

metaM HC01405 m
name: (S)-Hydroxyoctanoyl-CoA
is: CHEBI:28632
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN

metaM dcmp n
is: CHEBI:57566
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial concentration: 1.0
is: HMDB01202
initial amount: NaN
name: dCMP(2-)
constant: false
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_c410f43e_3640_4b5d_af1c_41c4978b27e1
is encoded by: hsa:10723
initial concentration: NaN
initial amount: NaN
name: SLC12A7
is: Q9Y666
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_8bb13594_7e39_475d_b39e_610a5a8214c3
is encoded by: hsa:37
is: P49748
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: ACADVL
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_ce417ca5_c6f8_4c18_81cd_22b02b47d735
constant: false
is encoded by: hsa:377841
is: SBO:0000252
is: Q5MY95
boundary condition: true
has only substance units: false
name: ENTPD8
type: Species
initial concentration: NaN
initial amount: NaN

metaR GCC2am
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110005#
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.4.4.2
type: Reaction
fast: false
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: true
is: SBO:0000176

metaR r2115
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110005#
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
reactant: MODEL1310110005#
fast: false

metaM hdd2coa m
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:61526
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: C05272
is: HMDB03945
name: trans-Hexadec-2-enoyl-CoA
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false

metaR PECDCHe
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of pectins with deoxycholic acid in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR r0355
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
modifier: MODEL1310110005#
type: Reaction
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/4.2.1.3
product: MODEL1310110005#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_042a99ca_20b5_4700_950c_8eddc4318c1e
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
name: UPP1
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7378
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_30a62532_b949_48d4_bd36_08da24763dd4
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:AI972237
name: _AI972237_1_c
boundary condition: true

metaM rnam c
constant: false
is: HMDB00855
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:15927
type: Species
name: N-Ribosylnicotinamide
notes: FORMULA: C11H15N2O5 CHARGE: 1 INCHI: InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1 EHMN_ABBREVIATION: C03150
boundary condition: false

metaM HC02207 e
is: CHEBI:27555
constant: false
is: SBO:0000247
name: prostaglandin-c2
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial amount: NaN
type: Species

metaM C02528 r
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:36234
boundary condition: false
is: SBO:0000247
name: chenodeoxycholate
initial amount: NaN
is: HMDB00518
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528

metaR r2084
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
reversible: true

metaR C226COAtx
fast: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110005#
is: SBO:0000185

metaR r2411
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110005#

metaM CE0785 m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:57795
name: cis,cis-myristo-5,8-dienoyl-CoA
has only substance units: false
initial amount: NaN

metaR FAS160COA
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
is described by: ECO:0000269
name: fatty-acyl-CoA synthase (n-C16:0CoA)
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000176

metaR ALCD21 D
modifier: MODEL1310110005#
is described by: ECO:0000304
fast: false
is: SBO:0000176
product: MODEL1310110005#
reversible: false
reactant: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.99.24
notes: GENE_ASSOCIATION: (127.1) or (284273.2) or (125.1) or (128.1) or (131.1) or (125.1 and 124.1) or (124.1) or (130.1) or (137872.1) or (125.1 and 126.1) or (126.1 and 124.1) or (284273.1) or (126.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
name: alcohol dehydrogenase (D-1,2-propanediol)

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR r2116
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110005#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_b65d90f6_d14f_4654_9ad5_e86033c1c695
has only substance units: false
initial amount: NaN
is encoded by: hsa:5742
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is: P23219
name: PTGS1
boundary condition: true

metaR r0354
is: SBO:0000176
modifier: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: false
fast: false
type: Reaction
name: Glycolysis / Glyconeogenesis EC:2.7.1.1

metaM CE5854 e
initial amount: NaN
type: Species
is: CHEBI:27485
has only substance units: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
initial concentration: 1.0
is: HMDB02710
constant: false
name: gama-CEHC-glucuronide
boundary condition: false
is: SBO:0000247

metaR KCCt
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
product: MODEL1310110005#
name: K+-Cl- cotransport
fast: false
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_df7f29d6_ed79_4680_9119_de4d1951104d
is: SBO:0000252
boundary condition: true
name: SDS
constant: false
is encoded by: hsa:10993
is: P20132
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN

metaM 12ppd R c
is: CHEBI:28972
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
initial amount: NaN
name: (R)-propane-1,2-diol
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
is: HMDB01881
has only substance units: false
boundary condition: false

metaM dttp e
type: Species
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial concentration: 1.0
is: CHEBI:37568
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
name: dTTP(4-)
boundary condition: false
is: HMDB01342

metaR r1109
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
fast: false
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
type: Reaction

metaM 1p3h5c m
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:6151
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: HMDB01369
initial concentration: 1.0
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
constant: false

metaR r2083
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110005#
reversible: true
type: Reaction
modifier: MODEL1310110005#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaR r1259
is described by: ECO:0000000
product: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110005#
type: Reaction
fast: false
is: SBO:0000176
name: EC:6.2.1.3
reversible: false

metaR DIDPtn
reactant: MODEL1310110005#
reversible: true
fast: false
name: dIDP nuclear transport
is described by: ECO:0000000
product: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185

metaR r2117
product: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185

metaM 6a2ohxnt x
has only substance units: false
is: HMDB12151
is: SBO:0000247
initial amount: NaN
name: 6-amino-2-oxohexanoic acid
is: CHEBI:17534
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
type: Species
boundary condition: false
constant: false
initial concentration: 1.0

metaM ala L m
is: CHEBI:16977
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00161
name: L-alanine
constant: false

metaR CH25H
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269
name: cholesterol 25-hydroxylase
product: MODEL1310110005#
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110005#
type: Reaction
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.14.99.38

metaR SRTNt6 2 r
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reversible: true
fast: false
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
modifier: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000269

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR FUMSO3tm
modifier: MODEL1310110005#
reversible: true
is described by: ECO:0000269
product: MODEL1310110005#
fast: false
name: Fumarate:sulfite antiport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
kinetic law: MODEL1310110005#
is: SBO:0000185
reactant: MODEL1310110005#

metaM fol c
constant: false
initial concentration: 1.0
notes: FORMULA: C19H18N7O6 CHARGE: -1
boundary condition: false
is: HMDB00121
name: Folate
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR r2086
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110005#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
fast: false

metaR LEUTA
name: leucine transaminase
type: Reaction
reversible: true
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
is: SBO:0000176

metaR r2110
fast: false
reversible: true
reactant: MODEL1310110005#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110005#
is described by: ECO:0000000
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction

metaR r0998
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false
name: Facilitated diffusion

metaR r2413
reversible: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_2e6e9f89_705c_4d60_9e06_a8e6d53eb918
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:1267
name: CNP
is: P09543
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR SARCStm
reversible: false
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
is: SBO:0000185
name: Sarcosine transport (mitochondrial)
type: Reaction
reactant: MODEL1310110005#

metaR r0130
type: Reaction
modifier: MODEL1310110005#
is described by: ECO:0000000
product: MODEL1310110005#
is: SBO:0000176
reversible: true
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
kinetic law: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:

metaM fum c
constant: false
is: SBO:0000247
is: CHEBI:29806
initial amount: NaN
is: C00122
boundary condition: false
name: Fumarate
initial concentration: 1.0
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
is: HMDB00134
type: Species
has only substance units: false

metaM nadp r
is: CHEBI:58349
is: SBO:0000247
constant: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
is: C00006
is: HMDB00217

http://identifiers.org/biomodels.db/MODEL1310110005#_31712863_3560_4b62_81cb_1543ed08f4a2
boundary condition: true
is: Q9HC58
initial concentration: NaN
is encoded by: hsa:57419
type: Species
initial amount: NaN
constant: false
name: SLC24A3
has only substance units: false
is: SBO:0000252

metaM retn r
is: SBO:0000247
constant: false
name: all-trans-retinoate
initial amount: NaN
is: CHEBI:35291
boundary condition: false
type: Species
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_94072d41_00fe_46c8_a672_aec6cdb9c8ea
is: H0UI06
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:1347
name: COX7A2
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM CE2422 m
type: Species
constant: false
initial concentration: 1.0
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
is: CHEBI:28387
is: HMDB11123
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_aed30355_5358_462e_930b_149da66d3525
boundary condition: true
name: CHKA
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:1119
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_4fd115af_6241_4cd8_a638_d1bc561bd5ed
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: P05062
has only substance units: false
name: ALDOB
is encoded by: hsa:229
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_23ade55a_3697_4544_9f3f_1b275ce8668d
initial concentration: NaN
is encoded by: hsa:M68895
has only substance units: false
initial amount: NaN
name: _M68895_1_c
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaM cdp c
is: CHEBI:58069
is: C00112
initial amount: NaN
boundary condition: false
name: CDP
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB01546
type: Species
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112

metaR GLYBt4 2 r
product: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110005#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
name: Betaine transport (sodium symport) (2:1)
fast: false

metaR r2111
modifier: MODEL1310110005#
fast: false
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110005#

metaR r0999
is described by: ECO:0000000
fast: false
product: MODEL1310110005#
name: Facilitated diffusion
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: true

metaR r2085
reactant: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110005#
reversible: true
type: Reaction
is: SBO:0000185
modifier: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_d9530cac_7e08_4a01_ab3f_b8210d5fb3a3
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q99808
is encoded by: hsa:2030
type: Species
name: SLC29A1
has only substance units: false
constant: false
initial concentration: NaN

metaR r0579
kinetic law: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
fast: false
product: MODEL1310110005#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.13.11.19
reactant: MODEL1310110005#
is: SBO:0000176
modifier: MODEL1310110005#
reversible: true
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

http://identifiers.org/biomodels.db/MODEL1310110005#_f6f86527_dc18_4f47_9427_5a4afa52f2d1
is: P35218
is encoded by: hsa:763
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
name: CA5A

metaR DNDPt9m
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
is described by: ECO:0000269
product: MODEL1310110005#
fast: false
reversible: false
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is: SBO:0000185
name: dADP transport via dTDP antiport

metaR RE2660N
modifier: MODEL1310110005#
name: RE2660
fast: false
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
reversible: true
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/4.2.1.96
is described by: ECO:0000000
type: Reaction
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176

metaM HC02121 c
boundary condition: false
type: Species
name: S-(hydroxymethyl)glutathione(1-)
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58758
constant: false
initial amount: NaN
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_304233eb_c174_4fe3_872c_f116fe6b6671
is: SBO:0000252
initial concentration: NaN
name: _BE966236_1_c
has only substance units: false
type: Species
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:BE966236

metaR r2338
reversible: true
fast: false
reactant: MODEL1310110005#
is: SBO:0000185
type: Reaction
product: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
kinetic law: MODEL1310110005#

metaR r2112
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_3f20be99_aa35_4fc5_a365_d35cf211ba91
is: Q9HC21
name: SLC25A19
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:60386
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_5829d066_37b9_422b_a053_202f172d656f
name: SLC26A2
initial concentration: NaN
is: P50443
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:1836
boundary condition: true
type: Species

metaM ethamp c
constant: false
name: ethamp[c]
has only substance units: false
is: HMDB00224
initial concentration: 1.0
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
initial amount: NaN
boundary condition: false
is: CHEBI:58190
is: SBO:0000247
type: Species

metaM glyc S c
is: CHEBI:33871
initial amount: NaN
constant: false
name: (S)-Glycerate
type: Species
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
is: HMDB06372
boundary condition: false

metaM nac e
name: Nicotinate
initial amount: NaN
type: Species
notes: FORMULA: C6H4NO2 CHARGE: -1
is: HMDB01488
constant: false
boundary condition: false
initial concentration: 1.0
is: C00253
is: CHEBI:0
has only substance units: false
is: SBO:0000247

metaM clpn hs c
type: Species
name: clpn_hs[c]
boundary condition: false
constant: false
notes: FORMULA: CHARGE: 0
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:15589
initial amount: NaN
is: HMDB00156

metaR r2088
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_61681678_1dff_4468_bce0_9966ec97f46b
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: ALPPL2
is encoded by: hsa:251
is: P10696
initial concentration: NaN

metaM asp D e
name: D-aspartate(1-)
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: SBO:0000247
is: CHEBI:29990
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB06483

metaR r0578
fast: false
reversible: true
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.27

metaR GLCt4
is: SBO:0000185
kinetic law: MODEL1310110005#
reversible: true
fast: false
name: glucose transport via sodium symport
type: Reaction
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
modifier: MODEL1310110005#
is described by: ECO:0000269
reactant: MODEL1310110005#
product: MODEL1310110005#

metaR ARACHCRNt
fast: false
product: MODEL1310110005#
reversible: false
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaR RE1527M
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110005#
name: RE1527
reversible: true
type: Reaction
product: MODEL1310110005#

metaR r1630
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaR HIStN1
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
kinetic law: MODEL1310110005#
reversible: true
is: SBO:0000185
name: Histidine transport (Na, H coupled)
product: MODEL1310110005#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction

metaM pmtcrn c
is: SBO:0000247
type: Species
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: CHEBI:17490
boundary condition: false
name: L-palmitoylcarnitine
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00222

http://identifiers.org/biomodels.db/MODEL1310110005#_4dbb9ab8_3856_4d2d_a35d_081ebe378cab
is encoded by: hsa:25769
name: SLC24A2
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q9UI40
type: Species
has only substance units: false
initial amount: NaN

metaM stcoa m
name: Stearoyl-CoA (n-C18:0CoA)
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:57394
constant: false
is: HMDB01114
boundary condition: false
is: C00412

metaR r2113
product: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
modifier: MODEL1310110005#
fast: false

metaM adp c
is: HMDB01341
is: C00008
is: CHEBI:16761
is: http://identifiers.org/pubchem.compound/3310
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
name: ADP
type: Species
is: SBO:0000247
initial amount: NaN

metaR 2MCITt
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:426765 NOTES:MM
is described by: ECO:0000000
fast: false
product: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
reversible: true
is: SBO:0000185
name: 2-methylcitrate transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110005#_0d77ed59_9835_4860_8a72_8541854bc453
type: Species
constant: false
name: SARDH
boundary condition: true
is: A8K596
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1757

http://identifiers.org/biomodels.db/MODEL1310110005#_d768ff13_480f_43be_a5db_9affd17c2c56
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:11001
name: SLC27A2
is: SBO:0000252
is: O14975
type: Species
boundary condition: true

metaR r2416
is described by: ECO:0000000
kinetic law: MODEL1310110005#
is: SBO:0000185
type: Reaction
reversible: false
product: MODEL1310110005#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_981f9d0e_9d51_4509_9b7c_11f4912f1aad
initial concentration: NaN
is: SBO:0000252
name: ATG9B
constant: false
has only substance units: false
is encoded by: hsa:285973
type: Species
initial amount: NaN
boundary condition: true
is: Q674R7

metaR r2087
kinetic law: MODEL1310110005#
is described by: ECO:0000000
fast: false
product: MODEL1310110005#
reversible: true
modifier: MODEL1310110005#
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110005#

metaR PPCDC
type: Reaction
product: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
is: SBO:0000176
reversible: false
is described by: ECO:0000269
name: phosphopantothenoylcysteine decarboxylase
is version of: http://identifiers.org/ec-code/4.1.1.36
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 4 AUTHORS: PMID:11923312 NOTES:

metaR TYRTA
is: SBO:0000176
fast: false
is described by: ECO:0000269
type: Reaction
reversible: true
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
name: tyrosine transaminase
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.6.1.1
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_64d80324_4b35_4368_b5dc_a22ca4288579
has only substance units: false
is: O43175
type: Species
boundary condition: true
is encoded by: hsa:26227
constant: false
initial concentration: NaN
is: SBO:0000252
name: PHGDH
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_9331ae34_19eb_4e58_b81a_cf29c6602fbe
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:728226
boundary condition: true
initial amount: NaN
type: Species
name: _728226_1_e

metaR r1631
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
is: SBO:0000185
product: MODEL1310110005#
is described by: ECO:0000000

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaR DURAD2
is: SBO:0000176
name: dihydrothymin dehydrogenase (NADP)
is described by: ECO:0000269
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.3.1.2
reversible: true
type: Reaction
modifier: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109

metaR r0022
type: Reaction
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.7
fast: false
modifier: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7

metaM dc2coa m
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: trans-Dec-2-enoyl-CoA
constant: false
is: CHEBI:61406

metaR RE1709N
is version of: http://identifiers.org/ec-code/4.2.1.96
name: RE1709
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
modifier: MODEL1310110005#
is: SBO:0000176
product: MODEL1310110005#
reactant: MODEL1310110005#

metaR CO2t
reactant: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
fast: false
name: CO2 transporter via diffusion
reversible: true
kinetic law: MODEL1310110005#

metaR RIBt
product: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110005#
name: ribose transport via diffusion
fast: false
reactant: MODEL1310110005#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD

metaR r2142
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110005#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_43b611a5_d877_4bf0_994d_fb1b0012b9dd
initial amount: NaN
type: Species
is: Q13825
is: SBO:0000252
is encoded by: hsa:549
initial concentration: NaN
constant: false
name: AUH
has only substance units: false
boundary condition: true

metaM thym c
is: HMDB00262
is: SBO:0000247
is: CHEBI:17821
initial amount: NaN
is: C00178
constant: false
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: Thymine
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178

metaR r1632
reversible: true
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_c110df67_1ccc_4d1c_aece_ebe28175e585
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:100128062
initial amount: NaN
name: _100128062_1_m
initial concentration: NaN
constant: false
boundary condition: true

metaR r0021
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110005#
product: MODEL1310110005#
reversible: true

metaR r0842
is described by: ECO:0000000
product: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.3.1.72
name: Postulated transport reaction
reversible: true
type: Reaction

metaR ALAATB0tc
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Alanine into the intestinal cells by ATB0 transporter
type: Reaction

metaR NADPtru
fast: false
reactant: MODEL1310110005#
name: NADP transporter, endoplasmic reticulum
reversible: false
is described by: ECO:0000000
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ

http://identifiers.org/biomodels.db/MODEL1310110005#_0c71df54_8dcb_480b_a1d4_64279e385736
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AW299740
initial amount: NaN
name: _AW299740_1_m
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_016df5db_b8aa_4ac5_92ae_fef0ebea14ad
type: Species
has only substance units: false
is encoded by: hsa:4357
is: SBO:0000252
constant: false
name: MPST
initial amount: NaN
boundary condition: true
is: P25325
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_153d5457_48ad_4460_816f_e2f7925a916a
is: SBO:0000252
boundary condition: true
is encoded by: hsa:27034
type: Species
initial amount: NaN
name: ACAD8
has only substance units: false
is: Q6ZWP6
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_07f8aca3_ea88_4fac_beb2_20fcac0a35fa
boundary condition: true
is encoded by: hsa:55350
type: Species
name: VNN3:VNN2:VNN1
has only substance units: false
initial concentration: NaN
initial amount: NaN
has part: A8K7W0
is: SBO:0000297
is encoded by: hsa:8875
is encoded by: hsa:8876
has part: O95497
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_979bdb3f_88f1_4f47_861f_75bdace70015
is: SBO:0000252
name: ENTPD1
initial amount: NaN
constant: false
is: Q86VV3
is encoded by: hsa:953
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species

metaR GULNter
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110005#
name: L-gulonate endoplasmic reticular export
fast: false
is: SBO:0000185
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reversible: false
type: Reaction

metaR LNLCCRNt
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
name: transport into the mitochondria (carnitine)

http://identifiers.org/biomodels.db/MODEL1310110005#_f38c0302_92e5_49e6_8f8b_a9b39b153160
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:93034
constant: false
name: NT5C1B
is: Q96P26
initial concentration: NaN

metaR r1633
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110005#_bb62fe3e_11ac_48dd_895b_d9b387386d4d
name: VNN3:VNN2:VNN1
initial concentration: NaN
is: SBO:0000297
constant: false
is encoded by: hsa:55350
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

metaR RE3520E
type: Reaction
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
reversible: true
name: RE3520
kinetic law: MODEL1310110005#
is: SBO:0000176
reactant: MODEL1310110005#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.11.1.9
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_03699442_4eb3_478a_8291_461a7ded998b
has only substance units: false
initial concentration: NaN
is encoded by: hsa:9154
boundary condition: true
name: SLC28A1
type: Species
constant: false
is: Q96PL7
initial amount: NaN
is: SBO:0000252

metaR r0575
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
modifier: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000000
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.48

http://identifiers.org/biomodels.db/MODEL1310110005#_b5c104c2_d345_47ad_9bc8_186d7e297fc0
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
name: HIBADH
is: P31937
boundary condition: true
has only substance units: false
is encoded by: hsa:11112

metaR DRIBt
fast: false
name: deoxyribose transport via diffusion
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
reactant: MODEL1310110005#
reversible: true
is: SBO:0000185
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_40aa4f71_701c_455b_be13_517e337ba5fa
has only substance units: false
is encoded by: hsa:F23536
type: Species
boundary condition: true
initial amount: NaN
name: _F23536_1_m
initial concentration: NaN
is: SBO:0000252
constant: false

metaM cdp e
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:58069
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
initial amount: NaN
name: CDP(3-)
initial concentration: 1.0
constant: false

metaR GAPD
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
is version of: http://identifiers.org/ec-code/1.2.1.12
kinetic law: MODEL1310110005#
is: SBO:0000176
reactant: MODEL1310110005#
type: Reaction
is described by: ECO:0000134
name: glyceraldehyde-3-phosphate dehydrogenase
reversible: true
product: MODEL1310110005#
fast: false
modifier: MODEL1310110005#

metaR r1634
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR ALCD21 L
reactant: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
product: MODEL1310110005#
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.99.24
name: alcohol dehydrogenase (L-1,2-propanediol)
is version of: http://identifiers.org/ec-code/1.1.1.1
is described by: ECO:0000304
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (125.1 and 124.1) or (128.1) or (126.1) or (284273.2) or (137872.1) or (127.1) or (124.1) or (126.1 and 124.1) or (284273.1) or (125.1 and 126.1) or (131.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157 NOTES:NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110005#_ce363985_67a1_4fc3_99cc_369acd46721e
constant: false
name: ALDH3B1
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:221
is: P43353
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_d8996fb7_42ac_4f95_a8cc_31db26fd68f9
is encoded by: hsa:8639
initial amount: NaN
is: Q16853
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
name: AOC3

http://identifiers.org/biomodels.db/MODEL1310110005#_1aa722bf_49f2_43af_a557_052694bf195f
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: HPGDS
initial concentration: NaN
is encoded by: hsa:27306
is: O60760
constant: false
type: Species

metaM udpgal e
type: Species
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:58439
constant: false
has only substance units: false
is: HMDB00302
initial amount: NaN

metaM 3mb2coa m
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB01493
is: CHEBI:57344
name: 3-methylbut-2-enoyl-CoA(4-)
boundary condition: false

metaR 34DHPLACOX NADP
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
reversible: true
reactant: MODEL1310110005#
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#

metaR 4MOPte
product: MODEL1310110005#
reversible: true
type: Reaction
reactant: MODEL1310110005#
fast: false
name: Transport of 4-methyl-2-oxopentanoate
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110005#

metaR CITtbm
name: citrate transport, mitochondrial
fast: false
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
is described by: ECO:0000269
product: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000185
reversible: true

metaM asp L e
has only substance units: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: CHEBI:29991
type: Species
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
name: L-aspartate(1-)
is: SBO:0000247
is: HMDB00191

metaR EX man LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Mannose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_3cbede37_288f_43d1_a0f9_0d0094c8d8fb
boundary condition: true
name: ADH1A
constant: false
initial concentration: NaN
is encoded by: hsa:124
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
is: P07327

metaM taur e
has only substance units: false
is: C00245
is: SBO:0000247
boundary condition: false
name: Taurine
is: CHEBI:3544
notes: FORMULA: C2H7NO3S CHARGE: 0
type: Species
constant: false
is: HMDB00251
initial concentration: 1.0
initial amount: NaN

metaM bilirub r
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial amount: NaN
is: HMDB00054
name: bilirubin(2-)
is: CHEBI:57977
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_b89ae10b_e9e6_4bcb_9288_46acdc4208a3
constant: false
initial concentration: NaN
is encoded by: hsa:4701
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q6FG42
type: Species
name: NDUFA7

http://identifiers.org/biomodels.db/MODEL1310110005#_e9335a7b_caef_4c86_98fd_dfb8904cc750
is encoded by: hsa:3945
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P07195
is: SBO:0000252
name: LDHB

metaR GLNATB0tc
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of L-Glutamine into the intestinal cells by ATB0 transporter
type: Reaction

metaR DNDPt12m
name: dADP transport via ADP antiport
modifier: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110005#
reversible: false
reactant: MODEL1310110005#
fast: false
is: SBO:0000185
product: MODEL1310110005#
is described by: ECO:0000269

metaR PGISr
product: MODEL1310110005#
is described by: ECO:0000134
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/5.3.99.4
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
reversible: true
name: Prostaglandin I2 synthase
fast: false
is: SBO:0000176
type: Reaction

metaR SARCStex
is: SBO:0000185
reactant: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#
is described by: ECO:0000000
name: Sarcosine transport (extracellular to cytosol)
type: Reaction
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES:MM
fast: false

metaR r1635
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#
is described by: ECO:0000000
modifier: MODEL1310110005#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_3a847a84_fcbd_414d_979e_f9a7748cf5d8
constant: false
is: SBO:0000252
is encoded by: hsa:AA629629
has only substance units: false
name: _AA629629_1_m
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_1d174a51_5024_4a29_ad21_752877e0933e
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P30038
constant: false
boundary condition: true
name: ALDH4A1
is encoded by: hsa:8659
has only substance units: false

metaR r1636
reactant: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110005#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_37976ce7_7973_437d_96b3_5cf4fc8ca2ae
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is: P05187
name: ALPP
type: Species
is encoded by: hsa:250

http://identifiers.org/biomodels.db/MODEL1310110005#_53b1d31a_60ef_4bad_a271_aae59ef0e205
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: NME1
type: Species
is: P15531
boundary condition: true
constant: false
is encoded by: hsa:4830
is: SBO:0000252

metaM gmp c
boundary condition: false
name: GMP
constant: false
type: Species
is: C00144
is: SBO:0000247
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial concentration: 1.0
initial amount: NaN
is: HMDB01397
is: CHEBI:58115
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_741bfb70_d544_4016_99ee_c61159021fca
is encoded by: hsa:5538
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
name: PPT1
is: Q6FGQ4

http://identifiers.org/biomodels.db/MODEL1310110005#_a131899d_5ca0_40bd_95ee_38e4c61ee88d
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:622
name: BDH1
has only substance units: false

metaR XOL7AONEtr
reversible: true
type: Reaction
kinetic law: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
reactant: MODEL1310110005#
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_a01abcf3_59fa_4fbb_8246_0dae7f841ebf
has only substance units: false
is: SBO:0000252
is: P09848
is encoded by: hsa:3938
initial concentration: NaN
boundary condition: true
name: LCT
type: Species
constant: false
initial amount: NaN

metaM 3mop c
name: 3-methyl-2-oxopentanoate
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: CHEBI:28654
is: HMDB00491
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false

metaM atp e
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57299
has only substance units: false
is: HMDB00538
constant: false
is: C00002
name: ATP(4-)

metaR RE1532M
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
modifier: MODEL1310110005#
name: RE1532
fast: false
reactant: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110005#_970d2e17_d1bc_41d1_b273_7ea596d0d4d6
type: Species
name: DCK
is: SBO:0000252
is encoded by: hsa:1633
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P27707
constant: false

metaM amet m
is: CHEBI:15414
has only substance units: false
boundary condition: false
is: HMDB01185
initial concentration: 1.0
type: Species
is: C00019
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
constant: false
name: S-Adenosyl-L-methionine

metaM asp L c
is: HMDB00191
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: SBO:0000247
type: Species
is: CHEBI:29991
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: L-aspartate(1-)
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_c855bbeb_f4e0_4aec_8bb5_231c70a58a9d
name: ACAT2
is encoded by: hsa:39
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: Q9BWD1

http://identifiers.org/biomodels.db/MODEL1310110005#_0c0e0612_67e2_4d2b_898a_310b64885362
name: GGT5
has only substance units: false
initial concentration: NaN
is: P36269
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:2687
initial amount: NaN

metaR r1637
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
modifier: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000185

metaR r2141
reversible: true
fast: false
modifier: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000

metaM taur c
initial amount: NaN
type: Species
is: CHEBI:3544
has only substance units: false
constant: false
boundary condition: false
name: Taurine
initial concentration: 1.0
notes: FORMULA: C2H7NO3S CHARGE: 0
is: HMDB00251
is: C00245
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_5958a5d4_50b1_42bc_a510_6bc44567f0ca
constant: false
initial amount: NaN
name: SLC26A1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:10861
has only substance units: false

metaR XOL7AH2tm
reversible: true
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
fast: false
name: lipid, flip-flop intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
type: Reaction

metaM nadp m
constant: false
initial concentration: 1.0
is: HMDB00217
is: C00006
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
is: CHEBI:58349
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_40cfe142_c266_43ac_b856_0aca37dae1f5
is encoded by: hsa:9489
is: Q32NB8
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
name: PGS1
initial amount: NaN
type: Species

metaR DCYTt
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
name: deoxycytidine transport via diffusion
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction
reversible: true

metaR Q10H2e
type: Reaction
kinetic law: MODEL1310110005#
is described by: ECO:0000134
reversible: true
name: transport of ubiquinol into lymph
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
fast: false
is: SBO:0000185
reactant: MODEL1310110005#
product: MODEL1310110005#

metaM lys L x
boundary condition: false
is: CHEBI:32551
name: L-lysinium(1+)
has only substance units: false
initial concentration: 1.0
is: HMDB00182
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: SBO:0000247
type: Species
constant: false
initial amount: NaN

metaR r0246
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000000
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
product: MODEL1310110005#
reversible: false
type: Reaction
reactant: MODEL1310110005#

metaR GLUt6
modifier: MODEL1310110005#
product: MODEL1310110005#
reversible: false
is: SBO:0000185
fast: false
kinetic law: MODEL1310110005#
type: Reaction
name: Glutamate transport via Na, H symport and K antiport
is described by: ECO:0000269
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (6511.1) or (6505.1) or (6507.1) or (6506.1) or (6512.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14530974 NOTES:SAB see Kanai and Hediger 2003

metaR ARACHCPT2
name: carnitine transferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110005#
reactant: MODEL1310110005#
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_1cf4d37c_549f_4b88_a54c_7d757e138dc0
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:10991
constant: false
name: SLC38A3
is: Q99624
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR RE1845X
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110005#
reversible: true
name: RE1845
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
kinetic law: MODEL1310110005#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110005#

metaM 5aop m
constant: false
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17549
has only substance units: false
is: C00430
boundary condition: false
name: 5-Amino-4-oxopentanoate
is: HMDB01149

metaR r1638
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_cc6b8f39_bcde_4dde_bd21_30ecbb938cba
is: SBO:0000252
is encoded by: hsa:AA081045
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
name: _AA081045_1_m

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaR r2140
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185

metaM Rtotal e
initial amount: NaN
is: CHEBI:16988
has only substance units: false
is: HMDB00283
type: Species
notes: FORMULA: CO2FULLR CHARGE: -1
constant: false
boundary condition: false
name: R total
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_7ef4500b_8c9c_47e6_b7f7_d94d874e5588
is: Q96T66
has only substance units: false
type: Species
is encoded by: hsa:349565
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: NMNAT3
constant: false
initial amount: NaN

metaR r0570
is described by: ECO:0000000
modifier: MODEL1310110005#
is: SBO:0000176
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
kinetic law: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
reversible: true
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/6.3.3.2

metaM q10 m
name: ubiquinone-10
is: SBO:0000247
is: CHEBI:46245
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
has only substance units: false
initial amount: NaN
is: HMDB01072

metaR r0245
kinetic law: MODEL1310110005#
fast: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
type: Reaction
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
reactant: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_54819e55_78b3_48c8_a80c_c5aced7bf963
boundary condition: true
is: SBO:0000252
is encoded by: hsa:NM 013421
name: _NM_013421_1_e
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_d68363e9_3b39_41d7_b144_5e513699b07b
constant: false
name: SLCO1B1
is encoded by: hsa:10599
type: Species
is: Q9Y6L6
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaM atp c
is: CHEBI:30616
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
type: Species
has only substance units: false
is: HMDB00538
name: ATP(4-)
is: C00002

metaM o2s x
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
name: superoxide
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:18421
has only substance units: false
is: HMDB02168
type: Species

metaR RE2349C
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
modifier: MODEL1310110005#
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.6.1.64
fast: false
is described by: ECO:0000000
reactant: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
type: Reaction
name: RE2349
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110005#_18f3bf77_15ad_4644_9ba2_c830b6b63def
type: Species
initial concentration: NaN
is: Q9BYV1
has only substance units: false
is encoded by: hsa:64902
initial amount: NaN
is: SBO:0000252
constant: false
name: AGXT2
boundary condition: true

metaM cholp c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:295975
is: SBO:0000247
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
has only substance units: false
name: choline phosphate(1-)
constant: false
boundary condition: false
type: Species

metaM 3hbcoa m
has only substance units: false
initial concentration: 1.0
is: CHEBI:57316
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: HMDB01166
name: (S)-3-hydroxybutanoyl-CoA(4-)
type: Species

metaM HC01602 c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
type: Species
is: C00234
has only substance units: false
name: 10-Formyltetrahydrofolate
is: CHEBI:57454
is: SBO:0000247

metaM ocdca e
is: C01530
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: octadecanoate (n-C18:0)
is: CHEBI:25629
type: Species
initial amount: NaN
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
is: HMDB00827
initial concentration: 1.0

metaR DMNONCRNt
kinetic law: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110005#

metaR PCm
is described by: ECO:0000269
reactant: MODEL1310110005#
product: MODEL1310110005#
modifier: MODEL1310110005#
name: pyruvate carboxylase
is: SBO:0000176
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/6.4.1.1

metaM pi e
boundary condition: false
is: SBO:0000247
is: C00009
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: CHEBI:43474
is: HMDB00973
type: Species
name: hydrogenphosphate

http://identifiers.org/biomodels.db/MODEL1310110005#_52c6ec39_de25_4ffc_9ff6_18c110538061
initial amount: NaN
name: GLUD2
has only substance units: false
is encoded by: hsa:2747
is: P49448
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN

metaM ump e
boundary condition: false
constant: false
name: UMP(2-)
initial amount: NaN
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:57865

metaM pmtcrn r
has only substance units: false
constant: false
name: L-palmitoylcarnitine
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: HMDB00222
is: SBO:0000247
is: CHEBI:17490

metaR r1628
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM gsn e
is: CHEBI:16750
constant: false
initial amount: NaN
name: Guanosine
is: C00387
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00133
type: Species
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387

metaM lnlncgcoa r
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
is: HMDB06368
has only substance units: false
boundary condition: false
is: CHEBI:57363
name: gamma-linolenoyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035

metaR RNDR4
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
reversible: false
modifier: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1
is described by: ECO:0000254
name: ribonucleoside-diphosphate reductase (UDP)
type: Reaction
fast: false
kinetic law: MODEL1310110005#

metaR ACACT1rm
reversible: true
product: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.9
is: SBO:0000176
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110005#
fast: false
name: acetyl-CoA C-acetyltransferase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110005#_5bd8acf0_9204_4325_aaf5_c59c61b8699b
type: Species
name: _AA081045_1_e
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AA081045
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_eb88fb55_335c_463b_ad9e_4cb225aa4397
name: UCK1
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q5JT09
initial amount: NaN
is encoded by: hsa:83549

metaM dad 2 c
constant: false
type: Species
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
is: SBO:0000247
boundary condition: false
name: 2-deoxyadenosine
initial amount: NaN
has only substance units: false
is: HMDB00101
initial concentration: 1.0
is: CHEBI:17256

metaR PRO Dtde
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
reactant: MODEL1310110005#
is described by: ECO:0000134
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110005#
name: D-proline transport, extracellular

metaM pchol hs m
initial amount: NaN
name: Phosphatidylcholine
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
has only substance units: false
is: CHEBI:16110

http://identifiers.org/biomodels.db/MODEL1310110005#_f9e1a926_9b45_49c6_9993_85056c88bc4f
type: Species
initial concentration: NaN
name: SLC26A11
constant: false
is: Q86WA9
is: SBO:0000252
is encoded by: hsa:284129
boundary condition: true
has only substance units: false
initial amount: NaN

metaM pep c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
name: Phosphoenolpyruvate
is: HMDB00263
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
type: Species
is: C00074
is: CHEBI:18021

http://identifiers.org/biomodels.db/MODEL1310110005#_740e7e20_28c5_44b4_b793_d096fda493b1
is encoded by: hsa:376497
type: Species
name: SLC27A1
is: SBO:0000252
initial amount: NaN
is: Q6PCB7
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r1627
fast: false
reversible: true
reactant: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110005#_5723fbd0_e3f2_4279_b4cb_ffa3257f50f1
boundary condition: true
constant: false
name: HAO1
has only substance units: false
is: Q9UJM8
initial amount: NaN
is encoded by: hsa:54363
type: Species
is: SBO:0000252
initial concentration: NaN

metaM C02528 c
name: chenodeoxycholate
is: CHEBI:36234
is: HMDB00518
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR OCDCAtr
fast: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
reversible: true
is: SBO:0000185
name: fatty acid transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaM ocdca c
constant: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
type: Species
has only substance units: false
name: stearate
is: CHEBI:25629
is: HMDB00827
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaM lys L m
type: Species
is: CHEBI:32551
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
initial concentration: 1.0
is: HMDB00182
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false

metaM ump c
is: CHEBI:57865
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
has only substance units: false
name: UMP
initial concentration: 1.0
is: C00105
initial amount: NaN
type: Species
is: HMDB00288
is: SBO:0000247

metaM arab L c
is: CHEBI:30849
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
name: L-arabinose
initial concentration: 1.0
constant: false
is: HMDB00646
notes: FORMULA: C5H10O5 CHARGE: 0

metaR EX bglc LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange reaction for beta glucans
type: Reaction

metaM cdp m
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false
initial concentration: 1.0
is: HMDB01546
name: CDP(3-)
type: Species
constant: false
has only substance units: false
is: CHEBI:58069

metaR GLYC St
reactant: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:9604805 NOTES:
reversible: false
name: L-glycerate export
fast: false
type: Reaction
product: MODEL1310110005#

metaM retn c
name: all-trans-retinoate
boundary condition: false
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:35291
is: HMDB01852

metaM retn e
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB01852
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
name: all-trans-retinoate
initial amount: NaN
is: CHEBI:35291

http://identifiers.org/biomodels.db/MODEL1310110005#_bdc32f29_5729_48cf_b3fa_98cf9491c7ee
initial concentration: NaN
is: B3KNC1
has only substance units: false
is encoded by: hsa:51733
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
constant: false
name: UPB1

metaR r0242
modifier: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
is described by: ECO:0000000
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/6.2.1.1
reversible: true
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:
type: Reaction

metaM dad 2 e
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:17256
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00101
boundary condition: false
name: 2-deoxyadenosine
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431

http://identifiers.org/biomodels.db/MODEL1310110005#_041f4e6d_bf0c_4bd9_a315_d3965fa9602b
has only substance units: false
name: _AI480132_1_c
is encoded by: hsa:AI480132
type: Species
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaM gsn c
is: SBO:0000247
is: HMDB00133
initial amount: NaN
type: Species
is: CHEBI:16750
initial concentration: 1.0
is: C00387
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
constant: false
has only substance units: false
boundary condition: false
name: Guanosine

metaR r0688
kinetic law: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
reactant: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
reversible: true
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110005#_a326c5ed_b074_4e5c_8fcc_9a7b3e0f84db
name: NDUFB1
is: O75438
is encoded by: hsa:4707
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM nh4 e
is: HMDB00051
has only substance units: false
name: ammonium
constant: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:28938
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_4bb2f558_d5db_4cc9_bbf7_6a028f1da2dc
constant: false
initial amount: NaN
has only substance units: false
is: Q5JT09
is: SBO:0000252
is encoded by: hsa:83549
initial concentration: NaN
type: Species
boundary condition: true
name: UCK1

metaR CHOLtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
type: Reaction
kinetic law: MODEL1310110005#
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110005#
reactant: MODEL1310110005#
name: Choline transport, nuclear through pores
is described by: ECO:0000000

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_dee885ad_6c2c_4128_810b_cba6ebc74457
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:AI971036
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: _AI971036_1_m

metaM glx c
type: Species
is: CHEBI:36655
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial concentration: 1.0
constant: false
name: glyoxylate
is: HMDB00119
boundary condition: false

metaM cdp n
initial amount: NaN
is: SBO:0000247
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)
type: Species
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB01546

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_b1e1fd69_1029_4c22_9e4a_cdf6ecc94595
is: P35354
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:5743
name: PTGS2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR CITtam
is described by: ECO:0000269
fast: false
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
name: citrate transport, mitochondrial
type: Reaction
product: MODEL1310110005#
reversible: true
is: SBO:0000185
reactant: MODEL1310110005#

metaR r1629
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_2c284f84_d56c_4bdd_b7e4_161aa3df1961
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: Q96CD2
is encoded by: hsa:60490
is: SBO:0000252
boundary condition: true
has only substance units: false
name: PPCDC

metaM ac m
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:30089
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00042
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033

metaR RE0512M
modifier: MODEL1310110005#
reversible: true
fast: false
reactant: MODEL1310110005#
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
is: SBO:0000176
name: RE0512
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
type: Reaction
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110005#_8fe33369_fa4e_4331_9249_2801cdf354ea
is: A0PJJ9
name: GGT7
is encoded by: hsa:2686
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species

metaR TYRt
fast: false
modifier: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
name: L-tyrosine transport
reactant: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
is described by: ECO:0000269

metaR r1418
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
is: SBO:0000176
product: MODEL1310110005#
is described by: ECO:0000000
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
type: Reaction

metaR SPMTDe
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
name: SPMTDe
is described by: ECO:0000134
product: MODEL1310110005#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110005#

metaR C4CRNe
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaR RE1903R
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reversible: true
name: RE1903
product: MODEL1310110005#
reactant: MODEL1310110005#

metaR SO4HCOtex
reversible: false
modifier: MODEL1310110005#
type: Reaction
is described by: ECO:0000304
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is: SBO:0000185
fast: false
name: sulfate transport via bicarbonate countertransport
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaM 2mcit e
is: HMDB00379
name: 2-methylcitrate(3-)
is: CHEBI:15598
type: Species
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false

metaM arab L e
is: CHEBI:30849
type: Species
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
name: L-arabinose
initial concentration: 1.0
is: HMDB00646

http://identifiers.org/biomodels.db/MODEL1310110005#_687d3568_c230_4e95_8715_1ac4146066b6
boundary condition: true
is: SBO:0000252
is: Q15392
has only substance units: false
name: DHCR24
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:1718
initial concentration: NaN

metaM HC02175 c
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: SBO:0000247
is: CHEBI:27689
name: caprate
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_bd607010_29ba_4a55_a436_572e1bc2e30f
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
is: E9PB82
name: HSD17B4
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:3295

metaR RE0944E
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0944
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
modifier: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17

metaM nadp c
is: C00006
is: CHEBI:58349
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00217
name: Nicotinamide adenine dinucleotide phosphate
type: Species
initial amount: NaN
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false

metaM orot c
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
type: Species
name: Orotate
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: C00295
is: HMDB00226
is: CHEBI:30839
initial amount: NaN

metaR r0791
reactant: MODEL1310110005#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_15cfe2cc_829e_4974_b789_f4634766fdf0
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: _AA081045_1_c
is encoded by: hsa:AA081045

metaM dcmp c
boundary condition: false
name: dCMP
is: CHEBI:57566
initial amount: NaN
type: Species
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: HMDB01202
initial concentration: 1.0
is: SBO:0000247
constant: false
is: C00239
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_d1be3b80_52e1_4909_baff_abf0dcd6e0dd
initial concentration: NaN
type: Species
is: P33121
name: ACSL1
constant: false
is encoded by: hsa:2180
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR CYTK14n
reversible: true
type: Reaction
reactant: MODEL1310110005#
name: cytidylate kinase (dCMP,CTP),nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110005#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110005#

metaM so3 m
name: hydrogensulfite
is: SBO:0000247
initial amount: NaN
is: CHEBI:17137
type: Species
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: HMDB00240
initial concentration: 1.0

metaR APAT2rm
modifier: MODEL1310110005#
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reactant: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/2.6.1.19

metaM nh4 c
constant: false
type: Species
boundary condition: false
is: C01342
is: HMDB00051
is: SBO:0000247
has only substance units: false
name: Ammonium
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28938
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaR ILEt5m
kinetic law: MODEL1310110005#
fast: false
reversible: true
name: Isoleucine mitochondrial transport
reactant: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000
type: Reaction

metaM pi c
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00973
initial amount: NaN
has only substance units: false
notes: FORMULA: HO4P CHARGE: -2
type: Species
is: SBO:0000247
is: C00009
name: hydrogenphosphate
is: CHEBI:43474

metaR r0027
is: SBO:0000176
fast: false
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
reversible: true
kinetic law: MODEL1310110005#
product: MODEL1310110005#
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.14.13.39
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110005#

metaM C05279 m
constant: false
type: Species
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: SBO:0000247
name: trans,cis-Lauro-2,6-dienoyl-CoA
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB11123
has only substance units: false
is: CHEBI:28387

http://identifiers.org/biomodels.db/MODEL1310110005#_d4f22091_7a06_4f55_a0ed_fd08d95a969f
boundary condition: true
constant: false
is: Q9NYW8
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:57786
name: RBAK
type: Species

metaM HC02175 e
name: caprate
initial concentration: 1.0
type: Species
is: CHEBI:27689
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1

metaR DM anth
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM 2mcit c
name: 2-methylcitrate(3-)
is: HMDB00379
is: CHEBI:15598
type: Species
notes: FORMULA: C7H7O7 CHARGE: -3 INCHI: InChI=1S/C7H10O7/c1-3(5(10)11)7(14,6(12)13)2-4(8)9/h3,14H,2H2,1H3,(H,8,9)(H,10,11)(H,12,13)/p-3
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false

metaR RNDR1
product: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
name: ribonucleoside-diphosphate reductase (ADP)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110005#_c744479c_6433_4dfb_9499_7d4d1fde29ed
is: SBO:0000252
is: O14521
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:6392
initial concentration: NaN
name: SDHD

metaM orot e
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
name: orotate
type: Species
is: HMDB00226
is: CHEBI:30839
initial amount: NaN
constant: false

metaR GLYBtm
is: SBO:0000185
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
fast: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
type: Reaction
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_5df6eafc_48a6_4512_a453_ea02a4cce126
is encoded by: hsa:2222
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P37268
constant: false
type: Species
name: FDFT1
has only substance units: false

metaM bglc e
initial amount: NaN
constant: false
is: SBO:0000247
is: C02862
is: http://identifiers.org/pubchem.compound/213144
name: beta-glucans
has only substance units: false
boundary condition: false
type: Species
is: HMDB02013
initial concentration: 1.0
notes: FORMULA: C1200000H2200000O1100000 CHARGE: 0

metaR H2Otly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110005#
is: SBO:0000185
type: Reaction
name: H2O transport, lysosomal
reversible: true
kinetic law: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
is described by: ECO:0000000

metaM 3snpyr c
has only substance units: false
constant: false
type: Species
is: HMDB02332
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
name: 3-Sulfinopyruvate
is: CHEBI:1665
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM prostgd2 c
is: HMDB01403
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: SBO:0000247
is: CHEBI:57406
type: Species
name: prostaglandin D2(1-)
initial concentration: 1.0

metaR FAEL183
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
name: fatty-acyl-CoA elongation (n-C18:3CoA)
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
is: SBO:0000176
type: Reaction

metaM occoa m
constant: false
has only substance units: false
type: Species
is: CHEBI:57386
initial concentration: 1.0
is: C01944
boundary condition: false
is: SBO:0000247
name: Octanoyl-CoA (n-C8:0CoA)
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial amount: NaN
is: HMDB01070

metaM thyox L e
name: L-thyroxine
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
initial amount: NaN
is: CHEBI:18332
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00248

http://identifiers.org/biomodels.db/MODEL1310110005#_185f35c8_28ca_4dba_8855_374cfc33d78c
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
name: NME1
is encoded by: hsa:4830
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_71a1318d_7bf1_499e_b633_61a1e489ed7f
name: PAH
is: SBO:0000252
has only substance units: false
is: P00439
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:5053
boundary condition: true

metaM lys L c
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: CHEBI:32551
boundary condition: false
constant: false
name: L-lysinium(1+)
is: HMDB00182
initial amount: NaN

metaR r1527
reactant: MODEL1310110005#
is described by: ECO:0000000
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
product: MODEL1310110005#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.1
is: SBO:0000185
fast: false
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_868162b6_02df_4d0e_b64f_4a579ea4aacc
type: Species
boundary condition: true
is: SBO:0000252
name: PPA1
constant: false
is: Q15181
is encoded by: hsa:5464
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_79ba3c5b_33ce_4a5f_a5b5_f7720a3a1105
is: SBO:0000252
boundary condition: true
is encoded by: hsa:80339
constant: false
name: PNPLA3
is: Q9NST1
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN

metaR CLHCO3tex2
is: SBO:0000185
product: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
reversible: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is described by: ECO:0000304
modifier: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
name: chloride transport via bicarbonate countertransport (2:1)

http://identifiers.org/biomodels.db/MODEL1310110005#_2e580a5b_837f_4c42_999f_1c98b057a430
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
name: ACAT1
type: Species
is encoded by: hsa:38
initial amount: NaN
is: P24752
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_733237c4_3e7f_4f39_ada4_c41214afab92
initial concentration: NaN
constant: false
name: NDUFB6
is: O95139
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:4712
type: Species

metaR r2333
fast: false
reversible: true
kinetic law: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR TSTSTERONEtr
reactant: MODEL1310110005#
fast: false
name: testosterone intracellular transport
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_adb3c21d_0b5b_4d70_986c_2e956fff4786
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:BE966236
name: _BE966236_1_m
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species

metaR G3PD2m
is described by: ECO:0000304
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (2820.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.99.5 Confidence Level: 2 AUTHORS: PMID:11385633,PMID:8549872 NOTES:replaces old version which contains redundant metabolite (gly3p) NCD split compartmentation NJ
reactant: MODEL1310110005#
is: SBO:0000185
type: Reaction
name: glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.5.3
fast: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reversible: false

metaR r1590
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
type: Reaction
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110005#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_30e69084_d08a_43b2_a9a3_98d33bcf445b
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1633
constant: false
initial amount: NaN
type: Species
name: DCK
is: SBO:0000252
is: P27707

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaM prostgd2 e
is: CHEBI:57406
initial concentration: 1.0
is: SBO:0000247
is: HMDB01403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
name: prostaglandin D2(1-)
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: false

metaM dttp m
is: CHEBI:37568
is: SBO:0000247
is: HMDB01342
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
type: Species
is: C00459
initial amount: NaN
name: dTTP
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_ab2c94fa_4494_4e92_99d1_6d42381da5ee
initial concentration: NaN
constant: false
name: AQP8
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: O94778
is encoded by: hsa:343
is: SBO:0000252

metaR LEUKTRE4t
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
is: SBO:0000185
name: leukotriene E4 transport
is described by: ECO:0000000
reversible: true
type: Reaction

metaR r2332
reactant: MODEL1310110005#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110005#
type: Reaction
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_ae9787e6_d41f_40b0_8f7c_7bb05ef32d05
name: EGFL8
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:80864
type: Species
is: SBO:0000252
is: Q99944
boundary condition: true
has only substance units: false

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_dc03c2ce_3894_43ce_8e3a_c9ca3fa19829
name: SLC17A3
constant: false
boundary condition: true
is: O00476
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:10786
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_6ca23c2f_acc0_4054_b0ee_76353871bd98
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
name: FOLR1
is encoded by: hsa:2348
is: SBO:0000252
type: Species
constant: false

metaM xol7ah2al c
is: SBO:0000247
boundary condition: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: CHEBI:27428
initial amount: NaN
is: HMDB06894
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
type: Species
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_cc04bead_24fb_42e4_a12d_8bcc53618af8
is: SBO:0000252
is encoded by: hsa:221823
initial amount: NaN
type: Species
name: PRPS1L1
boundary condition: true
is: P21108
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_c1987831_a435_4550_8867_3e6337f34bc6
is: E9PB82
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:3295
name: HSD17B4
has only substance units: false
constant: false
initial concentration: NaN

metaR PAIL4P HStn
reactant: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110005#
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
product: MODEL1310110005#
is: SBO:0000185

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaM ala D c
is: HMDB01310
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
constant: false
type: Species
is: CHEBI:15570
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: D-alanine
is: SBO:0000247

metaR r1591
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110005#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110005#
reactant: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM lys L e
is: SBO:0000247
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:32551
boundary condition: false
initial amount: NaN
is: HMDB00182
name: L-lysinium(1+)

metaM thyox L c
constant: false
is: HMDB00248
initial concentration: 1.0
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
type: Species
initial amount: NaN
is: CHEBI:18332
boundary condition: false
is: SBO:0000247
name: L-thyroxine
has only substance units: false

metaR ACCOALm
is described by: ECO:0000304
name: acetate-CoA ligase (AMP-forming)
reversible: false
fast: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (84532.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.17 Confidence Level: 2 AUTHORS: PMID:11150295 NOTES:TDV-mitochondrial version JLR- also acts on propanoate AMF- made reaction to create AMP not ADP and changed EC
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.1
modifier: MODEL1310110005#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_75796f8e_cc02_46e9_9d10_ea0cd8597694
constant: false
type: Species
name: _AA278423_1_m
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA278423

metaR r2335
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000185

metaR L LACDcm
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (124637.1) SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:18831974 NOTES:NCD/TDV. This reaction exists in yeast, but no evidence could be found this exists in humans. However, there may be intramitochondrial lactate dehydrogenase and lactate transport into mitochondria
fast: false
is described by: ECO:0000000
name: L-Lactate dehydrogenase, cytosolic/mitochondrial
product: MODEL1310110005#
type: Reaction

metaR DRPA
kinetic law: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110005#
name: deoxyribose-phosphate aldolase
is: SBO:0000176
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000

metaR RE2660C
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
kinetic law: MODEL1310110005#
name: RE2660
reactant: MODEL1310110005#
reversible: true
product: MODEL1310110005#

metaR r2079
is described by: ECO:0000000
kinetic law: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110005#
modifier: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM dttp n
name: dTTP
type: Species
is: CHEBI:37568
is: C00459
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01342

metaR PROSTGE2t2
reversible: true
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
is: SBO:0000185
product: MODEL1310110005#
fast: false
name: prostaglandin uniport
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
is described by: ECO:0000269

metaR CHOLtu
reactant: MODEL1310110005#
reversible: true
fast: false
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
name: Choline uniport
is: SBO:0000185
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
type: Reaction
is described by: ECO:0000269

metaR RE2079R
name: RE2079
is: SBO:0000176
type: Reaction
product: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
fast: false
reversible: true
is described by: ECO:0000000

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaM L2aadp6sa c
name: L-allysine
type: Species
is: CHEBI:17917
is: SBO:0000247
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
has only substance units: false
initial amount: NaN
is: HMDB01263
initial concentration: 1.0
boundary condition: false
constant: false

metaR 34HPPte
is: SBO:0000185
name: Transport of 3-(4-hydroxyphenyl)pyruvate
reactant: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#
is described by: ECO:0000134
type: Reaction

metaR r1592
type: Reaction
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
is described by: ECO:0000000

metaM strdnccoa m
is: C16163
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/47205473
initial amount: NaN
name: stearidonyl coenzyme A
initial concentration: 1.0
constant: false
is: HMDB06519
has only substance units: false
is: SBO:0000247
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110005#_25e78595_9fff_4004_a3ab_0396583d0675
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
name: SLC22A3
is encoded by: hsa:6581
is: SBO:0000252
is: Q5SYN6
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_ad42ce73_df7f_477e_a1b8_2f658171a03c
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
name: MYO5B
is encoded by: hsa:4645
is: Q9H6Y6

metaR r2334
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM HC00361 c
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
name: sedoheptulose 1,7-bisphosphate(4-)
boundary condition: false
is: CHEBI:58335
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447

http://identifiers.org/biomodels.db/MODEL1310110005#_e64b46cf_cf80_422c_99f6_2975c4f1b7d4
name: NDUFB9
is: Q9Y6M9
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4715
initial concentration: NaN
constant: false
has only substance units: false

metaM 4mop m
initial amount: NaN
is: CHEBI:17865
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
name: 4-methyl-2-oxopentanoate
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: HMDB00695
is: SBO:0000247

metaM pchol hs c
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00156
boundary condition: false
initial concentration: 1.0
name: pchol_hs[c]
notes: FORMULA: CHARGE: 0
is: CHEBI:15589
type: Species

metaR r0680
product: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.137
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_bfe58930_ba45_447f_b57b_09570469b2f8
boundary condition: true
is: Q6NVC0
name: SLC25A5
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:292

metaR ABTti
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: L-arabinitol transport via passive diffusion
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#

metaR ACACT10m
is described by: ECO:0000134
fast: false
type: Reaction
reactant: MODEL1310110005#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.9
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
kinetic law: MODEL1310110005#
product: MODEL1310110005#
modifier: MODEL1310110005#

metaM CE5788 e
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
initial concentration: 1.0
type: Species
name: kinetensin 1-7
is: HMDB02710
is: CHEBI:27485
is: SBO:0000247

metaR ADSL1
reactant: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.2.2
name: adenylosuccinate lyase
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
reversible: false

metaR r1593
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110005#
reversible: true
is: SBO:0000185
product: MODEL1310110005#

metaM ala D e
constant: false
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: CHEBI:15570
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01310
initial concentration: 1.0
boundary condition: false
name: D-alanine

metaM mescon m
is: CHEBI:36986
type: Species
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
is: HMDB00749
constant: false
name: Mesaconate
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaR LEUt5m
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
kinetic law: MODEL1310110005#
name: leucine mitochondrial transport
fast: false
reactant: MODEL1310110005#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR CYTK1m
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
kinetic law: MODEL1310110005#
is described by: ECO:0000134
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110005#
type: Reaction
name: cytidylate kinase (CMP),mitochondrial
reactant: MODEL1310110005#

metaM arachcrn c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: HMDB06460
name: arachidyl carnitine
has only substance units: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3

metaR r2119
reversible: true
is: SBO:0000185
reactant: MODEL1310110005#
fast: false
product: MODEL1310110005#
is described by: ECO:0000000
modifier: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110005#

metaM ala L e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
type: Species
is: HMDB00161
name: L-alanine
is: CHEBI:16977
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_e3681efa_bc74_4597_9bbb_1633f4bb9875
boundary condition: true
name: _AGPAT7_1_c
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AGPAT7
constant: false
has only substance units: false
initial concentration: NaN

metaR ILETA
name: isoleucine transaminase
type: Reaction
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110005#
product: MODEL1310110005#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#

metaR r1257
reversible: false
fast: false
type: Reaction
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176
reactant: MODEL1310110005#
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000

metaM pacald c
name: phenylacetaldehyde
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
initial amount: NaN
is: HMDB06236
type: Species
is: SBO:0000247
is: CHEBI:16424

metaR NDPK6n
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
is: SBO:0000176
fast: false
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is described by: ECO:0000304
product: MODEL1310110005#
type: Reaction
reversible: true

metaR r1594
is: SBO:0000185
kinetic law: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000

metaM ac e
name: acetate
type: Species
is: HMDB00042
is: CHEBI:30089
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
initial concentration: 1.0
is: SBO:0000247

metaR CYTK1n
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP),nuclear
kinetic law: MODEL1310110005#
reversible: true
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction

metaR r2118
is: SBO:0000185
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
fast: false

metaM retinal cis 9 c
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: CHEBI:17898
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: SBO:0000247
initial amount: NaN
is: HMDB01358
name: all-trans-retinal

http://identifiers.org/biomodels.db/MODEL1310110005#_ffbd525c_7a26_474b_bf46_b492bb64b4f1
type: Species
is encoded by: hsa:26289
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: AK5
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_560a56e5_3655_441c_b4c5_10e13687f9d7
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:H45672
has only substance units: false
name: _H45672_1_m

metaR EX gsn LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Guanosine
type: Reaction

metaM glx m
is: CHEBI:36655
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: glyoxylate
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: HMDB00119
constant: false
initial amount: NaN

metaR r0686
reactant: MODEL1310110005#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is described by: ECO:0000000
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.2.2
type: Reaction
fast: false
product: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is: SBO:0000176

metaR NDPK6m
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
fast: false
reversible: true
reactant: MODEL1310110005#
is described by: ECO:0000254
is: SBO:0000176
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaM itacon m
type: Species
name: itaconate(2-)
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:17240
constant: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
is: HMDB02092
is: SBO:0000247
boundary condition: false

metaR r1595
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
reactant: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR r0139
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110005#
fast: false
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110005#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.2.2
modifier: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110005#
is: SBO:0000176

metaM 20ahchsterol m
constant: false
initial concentration: 1.0
is: HMDB06283
initial amount: NaN
boundary condition: false
name: 20-hydroxycholesterol
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
type: Species
is: SBO:0000247
is: CHEBI:1296

metaM ala L c
type: Species
is: HMDB00161
name: L-alanine
boundary condition: false
is: CHEBI:16977
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048

metaR EX gthox LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxidized glutathione exchange
type: Reaction

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR THYOXt2
is described by: ECO:0000269
reversible: true
type: Reaction
name: T4 transport via facilitated diffusion
kinetic law: MODEL1310110005#
is: SBO:0000185
fast: false
product: MODEL1310110005#
modifier: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ

metaR r2331
is: SBO:0000185
kinetic law: MODEL1310110005#
type: Reaction
reversible: true
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_7edcf543_105d_449c_a9b0_41d0ddf6607f
type: Species
name: CA12
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:771
boundary condition: true
has only substance units: false

metaM ddcacoa m
is: SBO:0000247
boundary condition: false
name: Dodecanoyl-CoA (n-C12:0CoA)
constant: false
is: CHEBI:57375
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB03571
is: C01832
initial amount: NaN
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832

metaR r0796
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110005#
type: Reaction
fast: false
modifier: MODEL1310110005#
product: MODEL1310110005#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
reactant: MODEL1310110005#
is: SBO:0000176
reversible: true

metaR TXASr
name: Thromboxane-A synthase
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.99.5
reactant: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
kinetic law: MODEL1310110005#
product: MODEL1310110005#

metaR DNDPt27m
modifier: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000269
type: Reaction
name: dCDP transport via dTDP antiport
is: SBO:0000185

metaM guln c
name: L-gulonate
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
boundary condition: false
type: Species
has only substance units: false
constant: false
is: CHEBI:13115
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB03290

metaR r0683
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110005#
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
reversible: false
kinetic law: MODEL1310110005#
is: SBO:0000176

metaM fum m
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00134
is: CHEBI:29806
is: C00122
name: Fumarate
initial amount: NaN
type: Species

metaR r1596
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ac c
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
constant: false
is: HMDB00042
is: CHEBI:30089
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
name: acetate

metaR RE3050R
product: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
reversible: true
name: RE3050
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
kinetic law: MODEL1310110005#
is: SBO:0000176

metaR HACD9m
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
modifier: MODEL1310110005#
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
reactant: MODEL1310110005#
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110005#_ec7cdcba_5992_434d_a2c0_be68dba69014
is: P23378
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: GLDC
initial amount: NaN
constant: false
is encoded by: hsa:2731
type: Species

metaR VALt5m
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
reactant: MODEL1310110005#
name: Valine reversible mitochondrial transport
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110005#
is described by: ECO:0000000
product: MODEL1310110005#

metaR DCK1n
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reversible: true
fast: false
kinetic law: MODEL1310110005#
name: Deoxycytidine kinase, nuclear (ATP)
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.1.74
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110005#
type: Reaction

metaM pep m
has only substance units: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
name: Phosphoenolpyruvate
is: SBO:0000247
is: CHEBI:18021
is: HMDB00263
initial amount: NaN
boundary condition: false
is: C00074
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_b60d143e_fbc8_4df5_9456_c58444d27f65
is: SBO:0000252
is: P45954
is encoded by: hsa:36
name: ACADSB
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species

metaR NOt
type: Reaction
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
kinetic law: MODEL1310110005#
reversible: true
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
name: NO transport (diffusion)

metaM HC00229 e
initial concentration: 1.0
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
constant: false
initial amount: NaN
name: Isomaltose
has only substance units: false
is: CHEBI:28189
type: Species
is: SBO:0000247
boundary condition: false

metaR r2330
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#

metaM so3 c
is: SBO:0000247
name: Sulfite
is: HMDB00240
constant: false
is: C00094
is: CHEBI:17137
initial amount: NaN
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

metaR r0797
modifier: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000176
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
name: glycine N-choloyltransferase EC:2.3.1.65
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
kinetic law: MODEL1310110005#

metaR XYLTD Dr
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000176
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
name: xylitol dehydrogenase (D-xyulose-forming)

http://identifiers.org/biomodels.db/MODEL1310110005#_b1a97843_b656_43fa_9324_40d0bffc73e7
is: P30566
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: ADSL
initial concentration: NaN
is encoded by: hsa:158
is: SBO:0000252

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_05839b0d_cbe2_4fc8_9289_4b441a42c775
name: _AF116616_1_m
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AF116616
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true

metaR r1597
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_8504d011_0871_4ac2_9c95_22c482026260
is: P56181
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: NDUFV3
is encoded by: hsa:4731
type: Species
is: SBO:0000252

metaM itp n
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:57614
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
name: ITP(3-)
boundary condition: false
is: SBO:0000247
is: HMDB00189

metaM drib e
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
is: SBO:0000247
type: Species
constant: false
is: HMDB03224
has only substance units: false
is: CHEBI:28816
name: 2-deoxy-D-ribose
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_018f3282_ec45_49b7_82ff_d7d3e4214ddd
type: Species
initial concentration: NaN
is encoded by: hsa:314
name: AOC2
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaM CE5786 e
is: SBO:0000247
type: Species
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
initial concentration: 1.0
name: kinetensin
is: CHEBI:27485
is: HMDB02710
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN

metaR RNMK
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000269
modifier: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (54981.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.1.22 Confidence Level: 4 AUTHORS: PMID:15137942 NOTES:
reactant: MODEL1310110005#
reversible: false
name: ribosylnicotinamide kinase
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.22

metaR r0413
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
product: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
reactant: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
reversible: false
modifier: MODEL1310110005#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110005#_e90bbd8a_4ce7_48eb_b1d8_54455fb14b55
is: SBO:0000252
name: SDR16C5
is encoded by: hsa:195814
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: B3KT84
has only substance units: false

metaR r0787
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.1
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
modifier: MODEL1310110005#
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
type: Reaction
reversible: false
reactant: MODEL1310110005#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110005#_51da2306_4e39_4d3f_bbc2_7a5f914dc4de
boundary condition: true
is encoded by: hsa:54539
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
name: NDUFB11
is: Q9NX14

metaM coa m
initial amount: NaN
boundary condition: false
is: C00010
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
is: CHEBI:57287
constant: false
name: Coenzyme A
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_f611a3de_fb57_4b5e_bd57_ecb2625721cd
is encoded by: hsa:55089
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: Q969I6
name: SLC38A4
initial concentration: NaN

metaR GCALDD
reversible: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
is described by: ECO:0000304
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
name: Glycolaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110005#
type: Reaction
fast: false

metaM C02470 c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
is: http://identifiers.org/pubchem.compound/5485
boundary condition: false
is: HMDB00881
name: Xanthurenic acid
initial amount: NaN
type: Species
is: C02470
constant: false
has only substance units: false

metaR CYTK8n
product: MODEL1310110005#
type: Reaction
name: cytidylate kinase (CMP,dATP),nuclear
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_7c9e68f1_34a4_4d10_8fbc_8d725f101707
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
name: _R33828_1_c
is encoded by: hsa:R33828

metaR GLYKm
product: MODEL1310110005#
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.1.30
fast: false
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110005#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (2710.2) or (2712.1) or (2710.1) or (2713.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.30 Confidence Level: 2 AUTHORS: PMID:7987308 NOTES:TV
name: glycerol kinase

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaM 3hibutcoa m
boundary condition: false
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: HMDB01052
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: (S)-3-Hydroxyisobutyryl-CoA
is: CHEBI:28259
initial amount: NaN

metaM succoa m
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Succinyl-CoA
is: HMDB01022
constant: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:57292

metaM ppa e
constant: false
is: CHEBI:17272
initial amount: NaN
is: HMDB00237
boundary condition: false
has only substance units: false
name: propionate
type: Species
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: SBO:0000247

metaM abt e
is: SBO:0000247
is: HMDB01851
name: L-arabinitol
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:18403
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_b8e4992b_860e_4df7_990c_14821d663555
type: Species
is encoded by: hsa:AI971036
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: _AI971036_1_c

metaM 3mob m
is: CHEBI:11851
is: HMDB00019
name: 3-methyl-2-oxobutanoate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
constant: false
is: SBO:0000247

metaM coa n
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
type: Species
name: coenzyme A(4-)
initial amount: NaN
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287

http://identifiers.org/biomodels.db/MODEL1310110005#_412fb704_f053_4009_9e86_c97e7831d5ba
initial amount: NaN
constant: false
initial concentration: NaN
name: PDHX
boundary condition: true
is encoded by: hsa:8050
is: O00330
is: SBO:0000252
has only substance units: false
type: Species

metaR r1649
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110005#
product: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
modifier: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_bf0bbbf3_6a61_4506_8e78_c78a2c8a52ce
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2739
type: Species
is: Q04760
has only substance units: false
name: GLO1
constant: false
is: SBO:0000252

metaM man c
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
initial amount: NaN
is: C00159
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB00169
has only substance units: false
name: D-Mannose

metaR RE3627M
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is: SBO:0000176
fast: false
name: RE3627

metaR r0480
fast: false
is: SBO:0000176
product: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reactant: MODEL1310110005#
reversible: true
is described by: ECO:0000000

metaM drib c
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
constant: false
name: 2-deoxy-D-ribose
is: CHEBI:28816
is: HMDB03224

http://identifiers.org/biomodels.db/MODEL1310110005#_888e5c17_c12b_4815_98c2_a7b0d6d0203a
initial concentration: NaN
is encoded by: hsa:4833
name: NME4
boundary condition: true
is: O00746
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species

metaR r0560
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110005#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110005#
product: MODEL1310110005#
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:

metaM 34dhmald c
is: HMDB06242
constant: false
is: http://identifiers.org/pubchem.compound/7903
initial concentration: 1.0
initial amount: NaN
name: 3,4-Dihydroxymandelaldehyde
type: Species
boundary condition: false
is: SBO:0000247
is: C05577
has only substance units: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577

metaM co2 c
is: CHEBI:3313
is: SBO:0000247
has only substance units: false
is: C00011
notes: FORMULA: CO2 CHARGE: 0
type: Species
is: HMDB01967
initial amount: NaN
constant: false
initial concentration: 1.0
name: CO2
boundary condition: false

metaM cmp c
is: SBO:0000247
has only substance units: false
type: Species
is: C00055
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00095
name: CMP
is: CHEBI:60377
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_24bf7668_6dc1_41fe_8d48_f4a3ca9321ad
is: SBO:0000252
type: Species
is: O75251
name: NDUFS7
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:374291
initial concentration: NaN
constant: false

metaM hdca l
is: HMDB00220
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:7896
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
has only substance units: false
name: palmitate
constant: false

metaM s7p c
initial amount: NaN
boundary condition: false
name: Sedoheptulose 7-phosphate
type: Species
is: SBO:0000247
initial concentration: 1.0
is: C05382
has only substance units: false
constant: false
is: HMDB01068
is: CHEBI:57483
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382

metaR r0817
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.85
fast: false
is: SBO:0000185
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
product: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41

http://identifiers.org/biomodels.db/MODEL1310110005#_fa1b225b_bbf4_4c8f_ba3e_c1fc5bdc1367
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:27068
has only substance units: false
initial amount: NaN
name: PPA2
is: SBO:0000252
is: Q9H2U2
constant: false

metaR r2198
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110005#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction

metaR r1648
modifier: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaM fadh2 m
is: C01352
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
name: Flavin adenine dinucleotide reduced
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: HMDB01197
is: CHEBI:58307
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_ca2d6671_0c64_4182_8cc3_77b44f692178
is: Q16348
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6565
initial amount: NaN
boundary condition: true
name: SLC15A2
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_485a3225_57aa_4f1f_ad20_20fb850559cc
constant: false
name: CA5B
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:11238
boundary condition: true
is: Q9Y2D0

metaR 4ABUTtm
fast: false
name: 4-aminobutanoate mitochondrial transport via diffusion
kinetic law: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110005#
reversible: true
type: Reaction
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10407778 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110005#_126cb68a_ff95_45dd_86a4_4800d0b8bc22
is: SBO:0000252
type: Species
is encoded by: hsa:54407
is: Q96QD8
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: SLC38A2
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_12aad6ad_e39b_4e74_89fb_1deba777c174
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is: P16260
is encoded by: hsa:8034
name: SLC25A16

http://identifiers.org/biomodels.db/MODEL1310110005#_ac7ce10a_fbdc_4860_a53f_941863649a4b
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:4842
constant: false
is: B4DG68
boundary condition: true
name: NOS1
has only substance units: false

metaM abt c
name: L-arabinitol
type: Species
is: SBO:0000247
is: HMDB01851
boundary condition: false
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:18403

metaR r0784
fast: false
reactant: MODEL1310110005#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.38
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
product: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_3d56860c_8755_4f76_adc2_a94817c380ff
is encoded by: hsa:220
type: Species
constant: false
name: ALDH1A3
is: P47895
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR r0818
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000185
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:

metaM rib D c
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
name: D-ribose
is: HMDB00283
type: Species
initial concentration: 1.0
is: CHEBI:16988
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false

metaM dtmp m
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:26999
is: C00364
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial amount: NaN
name: dTMP
is: HMDB01227
initial concentration: 1.0
boundary condition: false
type: Species

metaR r1647
type: Reaction
fast: false
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110005#
reactant: MODEL1310110005#
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_650c4bec_4cfb_4c28_8015_639d4905b56a
type: Species
boundary condition: true
is encoded by: hsa:4645
is: SBO:0000252
name: MYO5B
is: Q9H6Y6
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false

metaR RE2659R
name: RE2659
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
product: MODEL1310110005#
fast: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_d6e5ca75_d6c7_4985_801e_7d41a55d2454
initial amount: NaN
type: Species
is: Q86WU2
is encoded by: hsa:197257
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
name: LDHD
initial concentration: NaN

metaM co2 e
is: HMDB01967
is: C00011
initial amount: NaN
name: CO2
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:16526
initial concentration: 1.0
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011

metaM cmp e
is: CHEBI:60377
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
name: CMP(2-)
type: Species
is: SBO:0000247
is: HMDB00095
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_7eea1591_f34e_47ef_baac_2d90f2b2d747
has only substance units: false
boundary condition: true
name: ACP2
is: SBO:0000252
initial concentration: NaN
type: Species
is: E9PCI1
is encoded by: hsa:53
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_b7011b29_6a55_45fc_8164_6386428a9e7f
initial amount: NaN
is: P00491
type: Species
name: PNP
is: SBO:0000252
is encoded by: hsa:4860
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaR ARABR
is described by: ECO:0000269
fast: false
name: arabinose reductase
product: MODEL1310110005#
type: Reaction
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.21

metaM Rtotal2 e
initial amount: NaN
notes: FORMULA: CO2FULLR2 CHARGE: -1
boundary condition: false
constant: false
is: CHEBI:16988
name: R total 2 position
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00283
initial concentration: 1.0

metaM CE4794 m
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
name: cis-6-dodecenoyl-CoA
type: Species
is: CHEBI:12947
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794

metaR r1646
type: Reaction
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
reversible: true
modifier: MODEL1310110005#
fast: false
is: SBO:0000185

metaM hdca r
constant: false
initial amount: NaN
is: CHEBI:7896
boundary condition: false
name: Hexadecanoate (n-C16:0)
type: Species
is: C00249
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
has only substance units: false
is: SBO:0000247
is: HMDB00220
initial concentration: 1.0

metaR L LACt4r
kinetic law: MODEL1310110005#
name: L-lactate reversible transport via sodium symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110005#

metaM cholcoa x
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:57373
name: choloyl-CoA(4-)
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: HMDB01374
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_d9331e61_192f_4a0d_b264_021b020680c1
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: SLC26A1
initial amount: NaN
is encoded by: hsa:10861
initial concentration: NaN

metaM thr L c
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:16857
initial concentration: 1.0
is: HMDB00167
name: L-threonine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_51b767ec_d106_434c_8d0f_1a675c49e6f2
constant: false
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
name: CA12
is: O43570
is encoded by: hsa:771
initial amount: NaN
initial concentration: NaN

metaR RPEc
reversible: true
kinetic law: MODEL1310110005#
name: ribulose 5-phosphate 3-epimerase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
reactant: MODEL1310110005#
fast: false
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110005#

metaR ABTArm
fast: false
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
reactant: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
is version of: http://identifiers.org/ec-code/2.6.1.19
is described by: ECO:0000269
product: MODEL1310110005#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_282199da_10fd_40e1_a5fc_9407d86ea9f2
boundary condition: true
is encoded by: hsa:257202
constant: false
name: GPX6
is: SBO:0000252
initial amount: NaN
is: P59796
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_283d65cb_fb62_4e9f_82cb_e5f8d3ecc888
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:275
has only substance units: false
boundary condition: true
name: AMT
is: P48728
type: Species
initial amount: NaN

metaR r0410
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
fast: false
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
is: SBO:0000176
product: MODEL1310110005#
type: Reaction

metaR DNDPt15m
type: Reaction
fast: false
modifier: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
kinetic law: MODEL1310110005#
is described by: ECO:0000269
name: dUDP transport via dGDP antiport
reversible: false
reactant: MODEL1310110005#

metaR MANt4
modifier: MODEL1310110005#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
type: Reaction
name: D-mannose transport via sodium cotransport
fast: false
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reactant: MODEL1310110005#

metaR PETOHMm hs
product: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
type: Reaction
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
reversible: false
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.1.1.17
name: phosphatidylethanolamine N-methyltransferase

metaR r1645
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
is: SBO:0000185
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
reversible: true

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaM dgtp c
is: HMDB01440
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
name: dGTP
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
has only substance units: false
is: CHEBI:16497
is: C00286
boundary condition: false

metaR DESAT20 2
modifier: MODEL1310110005#
fast: false
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
is: SBO:0000176
is described by: ECO:0000000
reversible: false

metaM hista c
boundary condition: false
constant: false
name: histamium
initial amount: NaN
is: CHEBI:58432
type: Species
is: SBO:0000247
is: HMDB00870
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
has only substance units: false
initial concentration: 1.0

metaR r1705
kinetic law: MODEL1310110005#
type: Reaction
reversible: false
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_2668e175_a70d_43e0_981d_f812c9baffb8
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI469183
initial concentration: NaN
name: _AI469183_1_x
boundary condition: true
constant: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_683d69cf_e875_4570_9d99_814887001b54
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P27144
is encoded by: hsa:205
boundary condition: true
type: Species
constant: false
is: SBO:0000252
name: AK4

metaM 4nph e
type: Species
boundary condition: false
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: 4-nitrophenolate
is: HMDB01232
is: CHEBI:57917
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_60a910c8_e89b_4d74_835a_7046f4f20bc8
name: HSD17B10
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:3028
is: Q99714
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_5ab18365_1a0f_4ff5_b975_b44d9a9f8460
constant: false
has only substance units: false
initial amount: NaN
is: Q9H845
initial concentration: NaN
is encoded by: hsa:28976
name: ACAD9
is: SBO:0000252
boundary condition: true
type: Species

metaM coa r
is: C00010
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB01423
name: Coenzyme A
constant: false
type: Species
is: CHEBI:57287
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_6e65f2b4_57ed_48f7_8996_77dafb90a586
is: Q99884
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: SLC6A7
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:6534

metaR r2089
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110005#
is described by: ECO:0000000
product: MODEL1310110005#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110005#

metaR r1644
is: SBO:0000185
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110005#
fast: false

metaR DESAT20 1
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
type: Reaction
reversible: false
modifier: MODEL1310110005#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)

metaM 3hpp m
type: Species
is: HMDB00700
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
has only substance units: false
name: 3-hydroxypropionate
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:16510
initial concentration: 1.0

metaR NDPK10n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110005#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
is described by: ECO:0000304
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
is: SBO:0000176
modifier: MODEL1310110005#
type: Reaction

metaM thr L e
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:16857
is: HMDB00167
initial concentration: 1.0
name: L-threonine
type: Species
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_475e7fef_8fa4_4feb_b0e3_dc9d444a105b
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6240
initial amount: NaN
name: RRM1
initial concentration: NaN
type: Species
is: P23921
constant: false

metaR r0789
is: SBO:0000176
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110005#
type: Reaction
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reactant: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_b4833647_46ba_40af_b44b_d4d9e1b2ea25
type: Species
initial amount: NaN
name: _AI348006_1_c
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:AI348006
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_13fcad21_4592_4544_ad43_f649f83e8772
is: O43280
is encoded by: hsa:11181
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: TREH
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_415671d3_b487_47b4_8171_52ed9bdec51e
type: Species
is encoded by: hsa:R39999
constant: false
boundary condition: true
name: _R39999_1_c
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR CYTK11n
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
reversible: true
product: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dGTP),nuclear
kinetic law: MODEL1310110005#

metaR r0788
kinetic law: MODEL1310110005#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
fast: false
product: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110005#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110005#_fa2d4391_32b4_4cb4_840d_1c3d52b115da
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is: Q8TF71
is encoded by: hsa:117247
name: SLC16A10
has only substance units: false

metaM ppa c
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
name: propionate
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17272
type: Species
constant: false
boundary condition: false
is: HMDB00237
has only substance units: false

metaR r1434
name: Transport reaction
type: Reaction
is: SBO:0000185
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110005#
fast: false
reactant: MODEL1310110005#

metaM 3hpcoa m
initial amount: NaN
boundary condition: false
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB06807
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
name: 3-hydroxypropanoyl-CoA(4-)
is: CHEBI:58528

metaR r1796
reactant: MODEL1310110005#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
type: Reaction
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110005#
reversible: false
fast: false
is: SBO:0000185
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_2cc6f6c4_9643_4caa_8132_072c361bc175
is: SBO:0000252
name: GK2
initial amount: NaN
initial concentration: NaN
constant: false
is: Q14410
type: Species
has only substance units: false
is encoded by: hsa:2712
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_c3fda40e_f38f_4908_bce5_750132676689
constant: false
type: Species
is: Q16774
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: GUK1
boundary condition: true
is encoded by: hsa:2987

metaR r0483
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
kinetic law: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
fast: false
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
reactant: MODEL1310110005#
reversible: true
is described by: ECO:0000000
is: SBO:0000176

metaR r1643
is described by: ECO:0000000
reactant: MODEL1310110005#
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
fast: false
product: MODEL1310110005#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_f77b2ea0_02e7_48a2_82a7_ff60ff43df51
name: PKM2
is: SBO:0000252
is encoded by: hsa:5315
is: P14618
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

metaR 3MOX4HOXPGALDOX
fast: false
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110005#
is: SBO:0000176
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
kinetic law: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110005#

metaM hista e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: histamium
is: CHEBI:58432
is: SBO:0000247
is: HMDB00870
type: Species
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
constant: false
has only substance units: false

metaM tchola x
boundary condition: false
type: Species
name: taurocholate
is: HMDB00036
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:36257
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_c327a8c7_d52a_4a33_88e9_fbb0580a5763
is: SBO:0000252
type: Species
name: ACSL6
is encoded by: hsa:23305
boundary condition: true
is: B2RB13
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM HC00319 c
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
boundary condition: false
type: Species
is: SBO:0000247
name: Malonate
has only substance units: false
constant: false
is: CHEBI:30794
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_03602ea7_85b3_42c1_b9de_6bf22732c522
is: SBO:0000252
name: _AI915649_1_c
boundary condition: true
constant: false
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI915649

metaR MCPST
modifier: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.8.1.2
is described by: ECO:0000134
type: Reaction
name: 3-mercaptopyruvate sulfurtransferase
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.8.1.2 Confidence Level: 4 AUTHORS: PMID:4828222 NOTES:MM AMF. assay developed to find activity in red and white blood cells
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110005#
fast: false

metaR METt4
product: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
name: L-methionine transport in via sodium symport
fast: false
modifier: MODEL1310110005#
reversible: false
type: Reaction
reactant: MODEL1310110005#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES:SAB

metaR CMPSAS
is version of: http://identifiers.org/ec-code/2.7.7.43
kinetic law: MODEL1310110005#
name: CMP sialic acid synthase
is: SBO:0000176
reactant: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
fast: false
is described by: ECO:0000304
reversible: false
product: MODEL1310110005#

metaM itp e
type: Species
name: ITP(3-)
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57614
is: HMDB00189

metaM 3mob c
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
has only substance units: false
initial amount: NaN
is: CHEBI:11851
name: 3-methyl-2-oxobutanoate
type: Species
constant: false
is: HMDB00019
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_b4ec1b94_39a1_4b91_9ff7_088122ce77e9
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:622
name: BDH1
boundary condition: true
has only substance units: false

metaM CE5119 m
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
name: trans-3-cis-8-tetradecadienoyl-CoA
type: Species
is: CHEBI:12947

http://identifiers.org/biomodels.db/MODEL1310110005#_2ddada7b_4ef3_4a3a_adbd_2d34e299b0c5
initial concentration: NaN
is encoded by: hsa:4709
name: NDUFB3
initial amount: NaN
is: Q6IB80
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false

metaR r1642
reversible: true
modifier: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaM nrpphr c
initial concentration: 1.0
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
initial amount: NaN
is: SBO:0000247
name: Norepinephrine
constant: false
is: HMDB00216
is: CHEBI:33569
has only substance units: false
boundary condition: false
type: Species

metaR FUMtm
fast: false
product: MODEL1310110005#
is described by: ECO:0000269
kinetic law: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
is: SBO:0000185
type: Reaction
name: fumarate transport, mitochondrial
reactant: MODEL1310110005#
modifier: MODEL1310110005#

metaR r0634
modifier: MODEL1310110005#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.1
product: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
reversible: true

metaR SUCCt2m
modifier: MODEL1310110005#
name: succinate transport, mitochondrial
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false

metaR PItn
is: SBO:0000185
name: phosphate transport, nuclear
kinetic law: MODEL1310110005#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
type: Reaction

metaR r0812
product: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41
reversible: true
modifier: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.85

metaM nrpphr e
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00216
boundary condition: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
type: Species
initial concentration: 1.0
is: CHEBI:33569
name: Norepinephrine
has only substance units: false

metaM ser L e
is: SBO:0000247
is: HMDB00187
name: L-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
initial amount: NaN
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17115
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_3c5ccd20_97f9_4a7f_af9d_0dbdec5f71b0
is: O76082
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SLC22A5
type: Species
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:6584

metaR SERGLYexR
kinetic law: MODEL1310110005#
is: SBO:0000185
name: L-Serine/Glycine reversible exchange
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
product: MODEL1310110005#
reversible: true

metaM 3mob e
constant: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
boundary condition: false
is: HMDB00019
name: 3-methyl-2-oxobutanoate
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:11851

metaM HC01415 m
constant: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:27537
name: (2E)-Octenoyl-CoA
boundary condition: false
has only substance units: false

metaM chsterol r
initial concentration: 1.0
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: CHEBI:16113
initial amount: NaN
name: cholesterol
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: HMDB00067

http://identifiers.org/biomodels.db/MODEL1310110005#_23bc8f28_4c8d_4dfb_9fa6_6e61126848a5
is: SBO:0000252
has only substance units: false
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: _LOC374569_1_e
is encoded by: hsa:LOC374569

metaM ibcoa m
name: isobutyryl-CoA(4-)
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
is: CHEBI:57338
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
is: HMDB01243
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR GCHOLAte
is described by: ECO:0000000
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110005#
type: Reaction
fast: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: true
is: SBO:0000185

metaR r1641
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
modifier: MODEL1310110005#

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_2b9b1c48_c0b1_4f07_830c_abd98cc3dceb
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:100287639
type: Species
name: _100287639_1_c
initial concentration: NaN

metaM CE2431 m
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
type: Species
is: SBO:0000247
is: CHEBI:57795
boundary condition: false
name: cis-deca-4-enoyl-CoA
initial concentration: 1.0

metaM HC02216 e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta
boundary condition: false
is: CHEBI:28922

metaR r0633
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.3
reversible: true
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176
modifier: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false
type: Reaction

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_a80194d3_a498_4a43_b3ec_5cc66fcf3ade
name: ACSL4
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2182
type: Species
has only substance units: false
is: Q5JWV8
constant: false
boundary condition: true
initial amount: NaN

metaM itp c
is: SBO:0000247
constant: false
is: CHEBI:57614
name: ITP(3-)
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081

http://identifiers.org/biomodels.db/MODEL1310110005#_00cbdc6d_4a14_43ab_8abe_c70a86a1071d
type: Species
has only substance units: false
name: GGT2
initial concentration: NaN
is encoded by: hsa:728441
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaR r1640
is: SBO:0000185
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110005#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_0954d500_3cc3_45d9_91d4_97f82cda79e8
boundary condition: true
is encoded by: hsa:AI761708
constant: false
type: Species
name: _AI761708_1_m
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_83f0e25f_33b2_4b90_bfe8_731433307015
is: SBO:0000252
is: E7EPA7
is encoded by: hsa:7086
has only substance units: false
constant: false
initial concentration: NaN
name: TKT
type: Species
boundary condition: true
initial amount: NaN

metaM HC02216 c
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial amount: NaN
name: prostaglandin-f2beta
constant: false
boundary condition: false
is: CHEBI:28922
has only substance units: false
initial concentration: 1.0
type: Species

metaM dtmp e
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: HMDB01227
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
boundary condition: false
name: dTMP(2-)
initial amount: NaN
is: SBO:0000247
is: CHEBI:26999

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_971b4913_9bb4_4c0b_83d1_63bd36ee1300
is encoded by: hsa:AI697028
has only substance units: false
initial amount: NaN
name: _AI697028_1_m
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN

metaR SPODM
is described by: ECO:0000269
reversible: false
is: SBO:0000176
type: Reaction
name: superoxide dismutase
fast: false
modifier: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.15.1.1
product: MODEL1310110005#

metaR H2CO3D
type: Reaction
product: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.1
is described by: ECO:0000000
reactant: MODEL1310110005#
name: carboxylic acid dissociation
fast: false
kinetic law: MODEL1310110005#

metaM ocdcea e
initial amount: NaN
is: HMDB00207
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:0
is: C00712
is: SBO:0000247
name: octadecenoate (n-C18:1)
has only substance units: false
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1

metaM ser L c
name: L-serine
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
has only substance units: false
constant: false
is: CHEBI:17115
is: HMDB00187
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaM dgtp e
name: dGTP
initial concentration: 1.0
type: Species
constant: false
is: HMDB01440
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: CHEBI:16497

metaM arachcrn m
initial concentration: 1.0
has only substance units: false
is: HMDB06460
constant: false
initial amount: NaN
boundary condition: false
type: Species
name: arachidyl carnitine
is: SBO:0000247
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_ba1d68f6_9ebb_473a_9cf9_79d4c5897c66
name: SLC6A5
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: Q9Y345
boundary condition: true
is encoded by: hsa:9152
type: Species
initial amount: NaN
constant: false

metaM cmp n
constant: false
initial concentration: 1.0
is: HMDB00095
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial amount: NaN
is: SBO:0000247
name: CMP(2-)
boundary condition: false
is: CHEBI:60377
type: Species

metaM xylt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: HMDB02917
name: xylitol
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:17151
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_bacfb990_4bf0_4c14_bab2_692745222cef
type: Species
is: SBO:0000252
is: Q14032
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
name: BAAT
is encoded by: hsa:570
initial concentration: NaN

metaR r0960
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
product: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#

metaR r0783
is version of: http://identifiers.org/ec-code/4.2.1.17
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
is: SBO:0000176
kinetic law: MODEL1310110005#
reversible: true
is described by: ECO:0000000
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110005#
type: Reaction

metaM glc D e
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
boundary condition: false
constant: false
is: HMDB00122
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:4167
type: Species
has only substance units: false

metaR r0630
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: true
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.1.3.1
is: SBO:0000176
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.2
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_ff9a656f_73d6_4168_b892_4b5fad7ffa1e
type: Species
is encoded by: hsa:5631
is: SBO:0000252
name: PRPS1
initial concentration: NaN
initial amount: NaN
is: P60891
constant: false
boundary condition: true
has only substance units: false

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaM leuktrB4 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
initial amount: NaN
is: SBO:0000247
is: CHEBI:57461
has only substance units: false
is: HMDB01085
type: Species
boundary condition: false
initial concentration: 1.0
name: leukotriene B4(1-)
constant: false

metaR r1588
type: Reaction
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110005#

metaR KCC2t
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
type: Reaction
fast: false
name: K+-Cl- cotransporter (NH4+)
reversible: true
product: MODEL1310110005#
is: SBO:0000185
modifier: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaM ocdcea c
initial amount: NaN
is: HMDB00207
constant: false
type: Species
boundary condition: false
is: C00712
is: CHEBI:0
has only substance units: false
is: SBO:0000247
name: octadecenoate (n-C18:1)
notes: FORMULA: C18H33O2 CHARGE: -1
initial concentration: 1.0

metaM cmp m
has only substance units: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:60377
name: CMP(2-)
type: Species
boundary condition: false
constant: false

metaM co2 m
has only substance units: false
is: C00011
name: CO2
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
boundary condition: false
constant: false
is: HMDB01967

http://identifiers.org/biomodels.db/MODEL1310110005#_9ec88cc0_3b40_4196_b5c5_1dd33fdad626
is: Q8NEM3
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:9194
boundary condition: true
name: SLC16A7
constant: false
initial concentration: NaN
type: Species

metaR G5SADrm
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
reversible: true
type: Reaction
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_9d764631_7df7_4dc8_9f44_244e8c7ff55c
type: Species
is: SBO:0000252
is: P42765
name: ACAA2
is encoded by: hsa:10449
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false

metaM dtmp c
is: C00364
is: CHEBI:26999
has only substance units: false
boundary condition: false
constant: false
type: Species
is: HMDB01227
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial concentration: 1.0
name: dTMP
is: SBO:0000247
initial amount: NaN

metaR EX dchac LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for deoxycholic acid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_d8fd11bc_f2b4_4edb_95b8_30b8299291cd
name: SLC38A5
initial concentration: NaN
initial amount: NaN
constant: false
is: Q8WUX1
is: SBO:0000252
is encoded by: hsa:92745
has only substance units: false
type: Species
boundary condition: true

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaR RE3004M
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
product: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
name: RE3004
modifier: MODEL1310110005#
fast: false
reversible: true
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

metaR r1589
reactant: MODEL1310110005#
is: SBO:0000185
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110005#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_ac63b64f_d1ad_400d_bf11_6a98e153481f
initial concentration: NaN
is: Q9UG56
type: Species
is encoded by: hsa:23761
has only substance units: false
boundary condition: true
name: PISD
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_b3a362e2_3a4f_477f_b7bb_803158616e2c
is encoded by: hsa:6888
is: SBO:0000252
name: TALDO1
is: P37837
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
type: Species

metaM xylt c
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
name: xylitol
initial concentration: 1.0
is: CHEBI:17151
has only substance units: false
constant: false
boundary condition: false
is: HMDB02917

metaR RE3568C
fast: false
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
name: RE3568
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_af9f8820_8a61_4dd1_8f32_d0623e0e7b42
name: RDH13
initial amount: NaN
type: Species
is: B3KVA3
has only substance units: false
is encoded by: hsa:112724
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_f5192338_914b_4799_9a9c_b1045f88340f
is: SBO:0000252
is: Q6LEN6
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:1103
name: CHAT
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_f99158bc_b543_43be_81e5_9f0d2d467084
initial amount: NaN
name: _LOC728997_1_c
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:LOC728997
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_1c88bbe7_86f3_4ab5_9322_2433c5b55558
is: Q96CD2
is encoded by: hsa:60490
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: PPCDC

metaR C40CPT1
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaM asn L e
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17196
initial concentration: 1.0
name: L-asparagine
type: Species
boundary condition: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: HMDB00168
has only substance units: false

metaM glc D c
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00122
is: CHEBI:4167
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_36b8b626_030a_484e_a32a_ba22ab76e035
is: SBO:0000252
is encoded by: hsa:9962
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
name: SLC23A2
initial concentration: NaN

metaM leuktrB4 e
initial amount: NaN
is: SBO:0000247
is: CHEBI:57461
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: HMDB01085
has only substance units: false
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
name: leukotriene B4(1-)

metaR r1586
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM dutp n
is: HMDB01191
is: SBO:0000247
is: CHEBI:17625
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
name: dUTP
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false

metaM coa l
type: Species
is: CHEBI:57287
initial amount: NaN
is: HMDB01423
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
constant: false
initial concentration: 1.0
name: coenzyme A(4-)
has only substance units: false
boundary condition: false

metaM malthp e
type: Species
has only substance units: false
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
is: http://identifiers.org/pubchem.compound/5041
constant: false
is: C01936
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: maltoheptaose
initial concentration: 1.0

metaM asn L c
boundary condition: false
initial amount: NaN
is: CHEBI:17196
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00168
type: Species
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
name: L-asparagine

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_8221926b_9a4d_449f_9f2f_a0ad3c81059b
name: NDUFAB1
is: O14561
has only substance units: false
is encoded by: hsa:4706
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR PPItx
is: SBO:0000185
reactant: MODEL1310110005#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
kinetic law: MODEL1310110005#
name: Diphosphate transporter, peroxisome
fast: false
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_b4c7a4ef_7242_4c42_8769_ffd1ea9ca330
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
name: LEFTY1
has only substance units: false
is: O75610
is: SBO:0000252
type: Species
is encoded by: hsa:10637

metaR r0780
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaM dutp m
type: Species
name: dUTP
initial concentration: 1.0
has only substance units: false
is: HMDB01191
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:17625
initial amount: NaN
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460

metaR r1587
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_84150508_07f6_4562_b18c_1997a976cd25
initial concentration: NaN
type: Species
is encoded by: hsa:641371
has only substance units: false
is: E9KL42
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ACOT1
constant: false

metaM CE5586 c
is: CHEBI:58732
boundary condition: false
type: Species
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_2142a2cd_3435_421d_91ee_0497ef260569
has only substance units: false
boundary condition: true
is encoded by: hsa:23057
name: NMNAT2
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_8925ea16_9243_4ec4_ad9a_eac8392c9431
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P42765
has only substance units: false
boundary condition: true
constant: false
name: ACAA2
type: Species
is encoded by: hsa:10449

metaR RE1898C
is: SBO:0000176
name: RE1898
reversible: true
type: Reaction
reactant: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
fast: false
is described by: ECO:0000000

metaR r1585
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM 3ohdcoa m
name: 3-oxopalmitoyl-CoA(4-)
is: HMDB06402
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
type: Species
has only substance units: false
constant: false
is: CHEBI:57349
is: SBO:0000247

metaM CE4790 m
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:12947
initial amount: NaN
is: SBO:0000247
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110005#_e3bcdea9_c850_40ce_9c7e_b27a2bc88e32
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:11136
type: Species
initial amount: NaN
is: P82251
boundary condition: true
constant: false
name: SLC7A9

metaR r0629
is version of: http://identifiers.org/ec-code/3.6.1.22
type: Reaction
product: MODEL1310110005#
is: SBO:0000176
modifier: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
reversible: true
is described by: ECO:0000000
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is version of: http://identifiers.org/ec-code/3.1.4.1
reactant: MODEL1310110005#

metaR DURIt
name: deoxyuridine transport via diffusion
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110005#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_7ea49eed_3237_4de0_a589_737264dad6e9
has only substance units: false
initial amount: NaN
type: Species
name: MECR
is: Q9BV79
boundary condition: true
is encoded by: hsa:51102
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_dc710ab1_74ac_40fc_ac9f_960e791eb571
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:10768
has only substance units: false
constant: false
is: O43865
name: AHCYL1
boundary condition: true

metaR r2366
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110005#
is: SBO:0000185
reactant: MODEL1310110005#
product: MODEL1310110005#

metaM HC00319 m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:30794
name: Malonate
constant: false
initial amount: NaN

metaM focytC m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
name: Ferrocytochrome C
constant: false
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
is: CHEBI:16928
has only substance units: false
is: SBO:0000247

metaR r0129
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reactant: MODEL1310110005#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.1.40
modifier: MODEL1310110005#

metaR r1584
type: Reaction
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185

metaR RE0383C
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
name: RE0383
reversible: true
product: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false
is: SBO:0000176

metaM mag hs e
is: SBO:0000247
type: Species
is: CHEBI:32387
constant: false
name: monoacylglycerol 2
initial concentration: 1.0
has only substance units: false
is: HMDB01388
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0

metaM dgtp n
is: CHEBI:16497
is: HMDB01440
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: C00286
is: SBO:0000247
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
name: dGTP
type: Species

metaM HC02180 e
is: SBO:0000247
constant: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
is: CHEBI:28728
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: thromboxane-b2
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_6c29a057_3091_4ba4_a31a_ef9470ad7b04
name: ABAT
is: SBO:0000252
is encoded by: hsa:18
has only substance units: false
constant: false
type: Species
boundary condition: true
is: P80404
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_ed1a83a0_c7e8_46f1_becd_d3ec17a1d64d
constant: false
name: OXSM
initial amount: NaN
initial concentration: NaN
is: Q9NWU1
is encoded by: hsa:54995
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true

metaM retinal 11 cis c
name: 11-cis-retinal
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:16066
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB02152

metaR r2367
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
product: MODEL1310110005#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true

metaR r0339
reactant: MODEL1310110005#
fast: false
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
type: Reaction
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.1.2.22
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: false
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110005#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_bbf26dc3_c802_4918_be05_dadfe3c6f779
constant: false
is encoded by: hsa:28976
name: ACAD9
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: Q9H845
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_cc21ef47_054f_4f60_bca3_b01a8d79bfbe
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
name: CA4
is: Q6FHI7
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:762

metaR 4ABUTtcn
fast: false
name: transport of GABA
is described by: ECO:0000134
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
product: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#

metaM acald e
initial amount: NaN
name: acetaldehyde
is: CHEBI:15343
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: HMDB00990
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM r1p c
type: Species
is: CHEBI:57720
is: HMDB01489
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00442
has only substance units: false
name: alpha-D-Ribose 1-phosphate
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442

metaR r0127
reversible: false
is version of: http://identifiers.org/ec-code/3.5.4.16
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
is: SBO:0000176
modifier: MODEL1310110005#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
product: MODEL1310110005#

metaR r1583
reactant: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
product: MODEL1310110005#

metaR r2090
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110005#
reversible: true
product: MODEL1310110005#
type: Reaction
modifier: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_eb800530_ced3_4638_be0c_159afcbea505
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: Q9BYZ2
name: LDHAL6B
is encoded by: hsa:92483
initial amount: NaN

metaR FAOXC180
is described by: ECO:0000269
reactant: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
reversible: false
kinetic law: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_75e19649_bf98_41bc_9706_b1405451afb3
is: Q308M7
initial amount: NaN
type: Species
is encoded by: hsa:5169
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
name: ENPP3

metaR r2364
is: SBO:0000185
reactant: MODEL1310110005#
fast: false
is described by: ECO:0000000
product: MODEL1310110005#
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true

metaR r0627
reactant: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
is: SBO:0000176
product: MODEL1310110005#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
fast: false
reversible: true

metaR ITCOAL1m
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is described by: ECO:0000304
reversible: true
fast: false
product: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/6.2.1.4
is: SBO:0000176
type: Reaction
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
modifier: MODEL1310110005#

metaR DUDPtn
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110005#
product: MODEL1310110005#
name: dUDP nuclear transport
reversible: true
fast: false
reactant: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110005#_c00ec7a8_567e_4092_916d_b3840523afed
name: COX7C
is encoded by: hsa:1350
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: P15954

http://identifiers.org/biomodels.db/MODEL1310110005#_d8c0717a_364f_4601_b6c4_fdfb31697438
is: SBO:0000252
initial concentration: NaN
name: UROD
initial amount: NaN
has only substance units: false
is: P06132
boundary condition: true
type: Species
is encoded by: hsa:7389
constant: false

metaM hom L c
name: L-homoserine
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: CHEBI:15699
is: SBO:0000247
is: HMDB00719
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_6d2bc29f_2fdd_466a_8b7c_862e754a20ad
boundary condition: true
type: Species
constant: false
is: A8MU28
is encoded by: hsa:8883
initial concentration: NaN
is: SBO:0000252
name: NAE1
initial amount: NaN
has only substance units: false

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaR DNDPt26m
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
is: SBO:0000185
reactant: MODEL1310110005#
name: dCDP transport via dUDP antiport

metaM pser L c
type: Species
name: O-Phospho-L-serine
initial amount: NaN
is: CHEBI:15811
is: HMDB01721
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
is: SBO:0000247
has only substance units: false

metaR PPItr
fast: false
product: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
reversible: true
name: Diphosphate transporter, endoplasmic reticulum
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR r2091
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000185
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000

metaM gln L c
boundary condition: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial amount: NaN
is: HMDB00641
type: Species
name: L-glutamine
constant: false
is: CHEBI:18050
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR r1871
modifier: MODEL1310110005#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110005#
reversible: false

metaM f6p c
boundary condition: false
is: HMDB00124
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3385
is: C00085
is: CHEBI:57579
type: Species
constant: false
has only substance units: false
name: D-Fructose 6-phosphate

metaM acetol c
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB06961
constant: false
initial concentration: 1.0
is: CHEBI:27957
name: hydroxyacetone
boundary condition: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3

http://identifiers.org/biomodels.db/MODEL1310110005#_c4a26f08_a6ed_43f2_8505_fdb047ff49a2
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SLC20A1
is: Q8WUM9
type: Species
is encoded by: hsa:6574
initial amount: NaN

metaR r2365
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is: SBO:0000185
type: Reaction
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110005#

metaR LEUPHELAT2tc
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM 44mctr r
has only substance units: false
is: CHEBI:17813
type: Species
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
is: HMDB01023
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455

metaR r1581
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110005#
fast: false
reversible: true
product: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR CHOLK
is version of: http://identifiers.org/ec-code/2.7.1.32
is: SBO:0000176
kinetic law: MODEL1310110005#
name: Choline kinase
fast: false
is described by: ECO:0000269
reactant: MODEL1310110005#
reversible: false
product: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110005#

metaM 34dhpac c
is: CHEBI:27978
name: 3,4-Dihydroxyphenylacetaldehyde
is: SBO:0000247
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB03791

http://identifiers.org/biomodels.db/MODEL1310110005#_58642519_d452_4a7b_89da_db6cf1c556b8
is encoded by: hsa:6536
name: SLC6A9
initial concentration: NaN
type: Species
is: B7Z3W8
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaM cit c
is: C00158
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000247
name: Citrate
initial concentration: 1.0
boundary condition: false
is: CHEBI:16947
is: HMDB00094

metaM acald c
is: CHEBI:15343
name: acetaldehyde
initial amount: NaN
type: Species
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00990
boundary condition: false
has only substance units: false

metaR UMPK3n
reactant: MODEL1310110005#
name: UMP kinase (UTP),nuclear
modifier: MODEL1310110005#
fast: false
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is: SBO:0000176

metaM ade c
is: CHEBI:16708
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
has only substance units: false
name: Adenine
type: Species
boundary condition: false
is: C00147
initial amount: NaN
is: HMDB00034
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR 3AIBTm
is: SBO:0000176
product: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.19
is described by: ECO:0000304
reactant: MODEL1310110005#
fast: false
name: L-3-aminoisobutyrate transaminase, mitochondrial

metaM glyald c
is: C00577
has only substance units: false
boundary condition: false
type: Species
constant: false
is: SBO:0000247
is: HMDB01051
name: D-Glyceraldehyde
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: CHEBI:17378

http://identifiers.org/biomodels.db/MODEL1310110005#_5737d438_7f8e_4433_8b67_f5df6740ab59
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5092
has only substance units: false
initial amount: NaN
name: PCBD1
type: Species

metaM glyb m
has only substance units: false
name: glycine betaine
type: Species
is: HMDB00043
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:17750

metaM hom L e
initial amount: NaN
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: CHEBI:15699
has only substance units: false
constant: false
name: L-homoserine
boundary condition: false
is: SBO:0000247
is: HMDB00719
initial concentration: 1.0
type: Species

metaM gcald c
boundary condition: false
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
is: HMDB03344
has only substance units: false
constant: false
name: glycolaldehyde
type: Species
initial concentration: 1.0
is: CHEBI:17071
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_ebd42cf0_63a1_4dd5_94f9_a35276ceebf6
is: Q5FC00
is: SBO:0000252
type: Species
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:765
name: CA6
initial amount: NaN

metaR PHCDm
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.5.1.12
is: SBO:0000176
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reversible: false
type: Reaction
is described by: ECO:0000304
fast: false

metaM fol e
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00121
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Folate

http://identifiers.org/biomodels.db/MODEL1310110005#_853f6d4f_0aac_444c_afd2_2b3a2e96855b
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: ALDH9A1
initial concentration: NaN
is: P49189
is encoded by: hsa:223

http://identifiers.org/biomodels.db/MODEL1310110005#_cfc6ad46_b925_49a3_a3be_9df56cf9ef0c
name: NME3
is: Q13232
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:4832
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_e5d2f732_2d69_4fe6_a005_57e62a214f28
name: SLC29A2
type: Species
is: SBO:0000252
is: Q14542
constant: false
has only substance units: false
is encoded by: hsa:3177
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_a91550cb_c54d_43e0_8636_c634c11fa18e
type: Species
is: SBO:0000252
constant: false
name: ACSS3
initial amount: NaN
is: Q9H6R3
has only substance units: false
is encoded by: hsa:79611
boundary condition: true
initial concentration: NaN

metaR r1580
type: Reaction
fast: false
reactant: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110005#
is described by: ECO:0000000

metaM gln L e
initial amount: NaN
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
has only substance units: false
is: SBO:0000247
is: CHEBI:18050
type: Species
name: L-glutamine
is: HMDB00641
constant: false
boundary condition: false
initial concentration: 1.0

metaM pe hs c
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:15589
type: Species
is: SBO:0000247
is: HMDB00156
constant: false
initial concentration: 1.0
notes: FORMULA: CHARGE: 0
name: pe_hs[c]

http://identifiers.org/biomodels.db/MODEL1310110005#_d8579aff_90bf_4aa9_b126_df83fdb94f25
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:100
has only substance units: false
name: ADA
is: P00813
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_55dfd748_629b_421b_bb6e_ea60cd42049a
is: P00326
boundary condition: true
name: ADH1C
initial concentration: NaN
is encoded by: hsa:126
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaM pnto R c
initial amount: NaN
initial concentration: 1.0
is: HMDB00210
is: CHEBI:7916
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
has only substance units: false
name: (R)-Pantothenate
type: Species
boundary condition: false
constant: false
is: SBO:0000247

metaR MDHm
name: malate dehydrogenase, mitochondrial
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
is version of: http://identifiers.org/ec-code/1.1.1.37
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reactant: MODEL1310110005#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_6a734bf6_ff1a_4ec6_9537_d9abf0f848fb
constant: false
has only substance units: false
type: Species
is encoded by: hsa:873
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P16152
name: CBR1

metaM eicostetcoa c
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
constant: false
initial concentration: 1.0
type: Species
is: C16164
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: eicosatetranoyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110005#_8038d022_bb9d_4ce0_a5a6_fd315d39b29d
has only substance units: false
name: AMY1C
type: Species
is: P04745
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:278
boundary condition: true
constant: false
is: SBO:0000252

metaM dutp c
constant: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial amount: NaN
has only substance units: false
is: C00460
type: Species
is: SBO:0000247
is: CHEBI:17625
name: dUTP
is: HMDB01191
initial concentration: 1.0
boundary condition: false

metaM tmndnccoa c
is: HMDB06514
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
name: timnodonyl coenzyme A
is: SBO:0000247
type: Species
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_5c245172_0642_4e9f_ad22_73d9dad4b73c
type: Species
is encoded by: hsa:50700
initial concentration: NaN
name: RDH8
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q9NYR8

metaR RE1573M
is described by: ECO:0000000
modifier: MODEL1310110005#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110005#
fast: false
name: RE1573
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/5.3.3.8
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_1effe774_494a_43c5_a765_398605b66fbe
initial concentration: NaN
boundary condition: true
name: SLC12A5
type: Species
is encoded by: hsa:57468
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is: Q9H2X9

http://identifiers.org/biomodels.db/MODEL1310110005#_c3e57fc2_cce9_466d_af68_c7b0c1a47a46
is: P24310
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:1346
name: COX7A1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_6c8f4f13_75cb_4a00_9ecc_f0542f6afb3c
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:48
name: ACO1
is: P21399
boundary condition: true

metaR DURIK1
is version of: http://identifiers.org/ec-code/2.7.1.21
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:
type: Reaction
reversible: false
fast: false
is described by: ECO:0000254
product: MODEL1310110005#
name: deoxyuridine kinase (ATP:Deoxyuridine)
is: SBO:0000176
reactant: MODEL1310110005#
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#

metaR GLYCLTtp
reactant: MODEL1310110005#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
name: glycolate transport into peroxisome
type: Reaction
kinetic law: MODEL1310110005#
is: SBO:0000185
reversible: false
product: MODEL1310110005#

metaR r2368
reactant: MODEL1310110005#
is described by: ECO:0000000
product: MODEL1310110005#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_1279c54b_ed8b_439a_b35d_b2a4edbaf84f
type: Species
has part: P09622
has part: P23434
has part: P48728
is encoded by: hsa:2653
has only substance units: false
is encoded by: hsa:1738
name: DLD:GCSH:GLDC:AMT
initial concentration: NaN
is encoded by: hsa:2731
has part: P23378
is encoded by: hsa:275
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000297

metaM ade e
is: CHEBI:16708
initial amount: NaN
constant: false
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
type: Species
name: adenine
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00034
is: SBO:0000247

metaR r1008
reactant: MODEL1310110005#
name: Facilitated diffusion
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110005#
type: Reaction
reversible: false
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_cfcb88a9_e70d_4d88_818a_ae843ca128e9
type: Species
constant: false
is: SBO:0000252
has only substance units: false
name: _NOS2A_1_e
is encoded by: hsa:NOS2A
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_8bea941a_0d39_44d8_b08a_3aaa6acc61a2
initial amount: NaN
name: GPX5
is: O75715
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2880
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaM HC02180 c
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
boundary condition: false
initial concentration: 1.0
name: thromboxane-b2
constant: false
is: CHEBI:28728
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247

metaR SBT Dtde
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
product: MODEL1310110005#
is: SBO:0000185
name: D-sorbitol transport, extracellular
reactant: MODEL1310110005#
reversible: true
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110005#

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_be396083_e535_4d1b_bf4a_f8cc65ccd09a
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaM coa c
is: C00010
is: CHEBI:3312
constant: false
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
is: HMDB01423
initial concentration: 1.0
type: Species
boundary condition: false
name: Coenzyme A
initial amount: NaN
is: SBO:0000247

metaM hcys L c
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
is: HMDB00742
name: L-homocysteine
boundary condition: false
is: CHEBI:17588
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247

metaR r2369
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: true
type: Reaction
fast: false
name: Organic anion transporter 5 Utilized transport

metaM orn m
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00214
name: Ornithine
type: Species
is: CHEBI:46912
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial amount: NaN
is: C01602
constant: false

metaM pnto R e
initial amount: NaN
is: HMDB00210
initial concentration: 1.0
is: CHEBI:7916
constant: false
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
has only substance units: false
name: (R)-Pantothenate

http://identifiers.org/biomodels.db/MODEL1310110005#_b63cae5d_7721_4129_8ffc_bbcd22965b18
has only substance units: false
initial amount: NaN
name: SLC24A4
is: SBO:0000252
is encoded by: hsa:123041
constant: false
type: Species
boundary condition: true
initial concentration: NaN

metaR r2097
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
modifier: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000

metaR ACCOAtn
type: Reaction
reversible: true
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110005#
is: SBO:0000185
name: acetyl-CoA transport, nuclear
kinetic law: MODEL1310110005#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_1742beee_85c6_4207_a6b4_b9aa5c579601
initial amount: NaN
name: _D29675_1_c
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:D29675
has only substance units: false

metaR MTHFD2
is described by: ECO:0000134
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
product: MODEL1310110005#
fast: false
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NAD)
kinetic law: MODEL1310110005#
is: SBO:0000176

metaR LCADi D
is: SBO:0000176
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
reactant: MODEL1310110005#
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110005#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.36
name: lactaldehyde dehydrogenase
type: Reaction
modifier: MODEL1310110005#

metaM HC00900 c
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: Methylmalonate
is: SBO:0000247
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
type: Species
is: CHEBI:30860
initial concentration: 1.0

metaR AHC
kinetic law: MODEL1310110005#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.3.1.1
modifier: MODEL1310110005#
reversible: true
reactant: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
product: MODEL1310110005#
is described by: ECO:0000269
name: adenosylhomocysteinase

metaR PYRt2m
modifier: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
fast: false
name: pyruvate mitochondrial transport via proton symport
reactant: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_0ac953a4_4599_40f8_9ad5_73b1a1051b32
constant: false
is encoded by: hsa:10768
boundary condition: true
is: SBO:0000252
name: AHCYL1
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_39949ae6_17f5_4914_9adc_d94dbb30b802
name: SLC7A5
has only substance units: false
is: Q8IV97
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:8140

metaM glutcoa m
constant: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
type: Species
is: SBO:0000247
is: HMDB01339
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57378
name: glutaryl-CoA(5-)
has only substance units: false
boundary condition: false

metaR EX galside hs LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-galactosyl-N-acylsphingosine exchange
type: Reaction

metaR MERCPLACCYSt
type: Reaction
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
reversible: false
is: SBO:0000185
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaM o2 c
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
is: SBO:0000247
initial concentration: 1.0
name: O2
is: HMDB01377
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:15379
is: C00007
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_0013e7c9_15f7_40e7_93ba_31d6305357c5
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:3032
name: HADHB
is: P55084
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR PPItm
reactant: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
name: diphopshate transporter, mitochondrial
is described by: ECO:0000134

metaM leuktrE4 e
is: CHEBI:57462
constant: false
boundary condition: false
has only substance units: false
name: leukotriene E4(1-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: HMDB02200
initial concentration: 1.0
type: Species

metaR r2098
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110005#
type: Reaction
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_af259887_b8dd_4b98_8c38_24b1518781a9
name: _AI990637_1_x
initial concentration: NaN
is encoded by: hsa:AI990637
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false

metaR PROSTGI2t
reactant: MODEL1310110005#
is described by: ECO:0000269
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
product: MODEL1310110005#
name: Prostaglandin I2 transport
fast: false
kinetic law: MODEL1310110005#
is: SBO:0000185

metaM lnlc c
initial amount: NaN
is: CHEBI:30245
name: linoleate
initial concentration: 1.0
is: HMDB00673
has only substance units: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
constant: false
type: Species
boundary condition: false
is: SBO:0000247

metaM ppa m
type: Species
initial amount: NaN
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial concentration: 1.0
is: HMDB00237
constant: false
is: CHEBI:17272
boundary condition: false
is: SBO:0000247
has only substance units: false
name: propionate

http://identifiers.org/biomodels.db/MODEL1310110005#_46676de5_d6b0_4b7d_831d_e0b29b92b98d
constant: false
name: GLUL
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:2752
initial amount: NaN
is: P15104
has only substance units: false
is: SBO:0000252

metaR r0331
product: MODEL1310110005#
is described by: ECO:0000000
modifier: MODEL1310110005#
fast: false
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_204890c8_6c27_4a13_b828_82462e5a34ef
is: P13073
is encoded by: hsa:1327
type: Species
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: COX4I1
has only substance units: false
initial concentration: NaN

metaM sbt D c
initial amount: NaN
boundary condition: false
is: HMDB00247
initial concentration: 1.0
constant: false
type: Species
name: D-glucitol
is: CHEBI:17924
has only substance units: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: SBO:0000247

metaR ALDD2y
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110005#
fast: false
name: aldehyde dehydrogenase (acetaldehyde, NADP)
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR RDH2
reversible: true
type: Reaction
name: retinol dehydrogenase (9-cis,NADH)
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
reactant: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.315
product: MODEL1310110005#

metaR CSNAT2x
modifier: MODEL1310110005#
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110005#
is: SBO:0000176
product: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.7
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.137

http://identifiers.org/biomodels.db/MODEL1310110005#_a14b60ae_ce6b_411e_a8b8_317404172de2
name: _286297_1_c
is: SBO:0000252
is encoded by: hsa:286297
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
initial amount: NaN

metaR RE2972M
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
type: Reaction
name: RE2972
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.1.67
kinetic law: MODEL1310110005#
reversible: true
is: SBO:0000176

metaR r1877
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110005#
type: Reaction
fast: false
kinetic law: MODEL1310110005#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110005#
reversible: false

metaM sbt D e
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB00247
boundary condition: false
type: Species
is: SBO:0000247
name: D-glucitol
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_f3249ee4_514e_4ddb_8f22_1832ada60372
constant: false
has only substance units: false
is encoded by: hsa:7296
is: SBO:0000252
initial amount: NaN
name: TXNRD1
boundary condition: true
type: Species
is: Q16881
initial concentration: NaN

metaR r1117
kinetic law: MODEL1310110005#
name: Facilitated diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
is: SBO:0000185
reactant: MODEL1310110005#
reversible: true
type: Reaction
fast: false
product: MODEL1310110005#

metaM 2oxoadp m
boundary condition: false
is: HMDB00225
is: SBO:0000247
name: 2-oxoadipate(2-)
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
has only substance units: false
is: CHEBI:57499
initial amount: NaN

metaR r2099
fast: false
kinetic law: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
reactant: MODEL1310110005#
is described by: ECO:0000000
modifier: MODEL1310110005#
product: MODEL1310110005#
type: Reaction

metaR ARAB Lt
name: L-arabinoase extracellular transport
fast: false
product: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110005#
reversible: true
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_766bfcdc_ae17_4cf4_b093_6f709a3881ed
is: SBO:0000252
is: Q02252
name: ALDH6A1
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:4329
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_04dea6f4_8c67_4910_ad01_e9d7cf5b192d
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:4716
type: Species
is: SBO:0000252
is: A8K761
name: NDUFB10
has only substance units: false
boundary condition: true

metaM leuktrE4 c
is: CHEBI:57462
name: leukotriene E4(1-)
constant: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB02200
type: Species
boundary condition: false

metaR AMPtp
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
type: Reaction
reversible: true
name: AMP transporter, peroxisome
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110005#

metaM o2 e
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
type: Species
initial concentration: 1.0
is: HMDB01377
constant: false
is: C00007
name: O2
initial amount: NaN
is: CHEBI:15379
has only substance units: false
boundary condition: false

metaR NH4tn
is: SBO:0000185
name: ammonia nuclear transport
fast: false
type: Reaction
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110005#_da0be7a0_2cde_4690_b2dc_1440f479d39c
is: E9KL44
initial amount: NaN
is: SBO:0000252
name: HADHA
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:3030
type: Species

metaR DNDPt16m
kinetic law: MODEL1310110005#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110005#
fast: false
name: dUDP transport via dADP antiport
reactant: MODEL1310110005#
modifier: MODEL1310110005#
reversible: false

metaR r1116
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
kinetic law: MODEL1310110005#
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_a7760d0c_4735_49be_9655_aff00e3bfb1a
has only substance units: false
constant: false
name: PYCR1
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:5831
is: A6NFM2

http://identifiers.org/biomodels.db/MODEL1310110005#_566066d1_16ac_4a21_b628_363282d92305
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:AI769281
type: Species
name: _AI769281_1_e

metaM CE4872 c
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
is: SBO:0000247
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
constant: false
is: CHEBI:15748
has only substance units: false
type: Species
boundary condition: false
is: HMDB00127
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_d21ac85c_632e_4962_a1df_1daa56c455a5
boundary condition: true
is: SBO:0000252
is encoded by: hsa:883
constant: false
name: CCBL1
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q16773

metaM pristcoa x
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
initial concentration: 1.0
is: CHEBI:51341
type: Species
name: pristanoyl coa
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false

metaR LPCOXp
type: Reaction
product: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000269
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.5.3.1
reactant: MODEL1310110005#
name: L-pipecolate oxidase, peroxisomal
kinetic law: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_018f8da2_c17e_4852_a7db_1abedf490fd5
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: TYMS
boundary condition: true
type: Species
is: P04818
has only substance units: false
is encoded by: hsa:7298

metaM dcamp c
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: CHEBI:57567
initial amount: NaN
name: N6-(1,2-Dicarboxyethyl)-AMP
is: SBO:0000247
is: HMDB00536
is: C03794

metaR AKR1C41
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
modifier: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110005#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.225
fast: false

metaM glyb e
constant: false
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
name: glycine betaine
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00043
is: CHEBI:17750
initial amount: NaN

metaR 2HBO
is version of: http://identifiers.org/ec-code/1.1.1.27
modifier: MODEL1310110005#
type: Reaction
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
reactant: MODEL1310110005#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
reversible: true
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#

metaR r2093
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_62e7d9a6_88fb_47c0_824b_395226a66109
is: P25325
has only substance units: false
name: MPST
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:4357
initial amount: NaN

metaR r2362
product: MODEL1310110005#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR r2092
product: MODEL1310110005#
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_2d44f99d_c8cb_4f0a_a804_221708cd08a8
is encoded by: hsa:6519
name: SLC3A1
is: Q07837
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_a34c9676_ff61_4328_81f4_0b5938d844b6
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:D29675
constant: false
name: _D29675_1_e
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_cc8c8a30_6560_4900_a301_431daec635fb
is: P11310
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: ACADM
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:34

http://identifiers.org/biomodels.db/MODEL1310110005#_c106396e_c8d8_42a3_b149_8887cdd303d4
name: UCK2
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q9BZX2
is encoded by: hsa:7371
constant: false
initial amount: NaN
type: Species

metaM orn c
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: SBO:0000247
is: C01602
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00214
initial concentration: 1.0
is: CHEBI:0
boundary condition: false
type: Species
name: Ornithine

metaM dmnoncoa c
constant: false
is: HMDB11604
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial concentration: 1.0
is: SBO:0000247
name: 4,8 dimethylnonanoyl-CoA
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_785c61ee_bb92_4e3d_8a14_73884e688645
type: Species
has only substance units: false
boundary condition: true
name: _T83654_1_m
constant: false
is encoded by: hsa:T83654
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR r2363
kinetic law: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110005#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
type: Reaction
reactant: MODEL1310110005#
fast: false

metaM gln L m
is: HMDB00641
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: CHEBI:18050
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: L-glutamine
initial amount: NaN

metaR r2094
is: SBO:0000185
fast: false
modifier: MODEL1310110005#
reversible: true
product: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaM anth c
is: CHEBI:16567
initial amount: NaN
is: HMDB01123
has only substance units: false
name: anthranilate
boundary condition: false
constant: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_27901eb3_15b3_4914_937f_d2765c6e8f2e
is: SBO:0000252
name: GCSH
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:2653
initial amount: NaN
initial concentration: NaN
is: P23434
constant: false

metaR DCYTDn
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
type: Reaction
is: SBO:0000176
modifier: MODEL1310110005#
reversible: false
reactant: MODEL1310110005#
name: deoxycytidine deaminase, nuclear
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.5
product: MODEL1310110005#
is described by: ECO:0000254
kinetic law: MODEL1310110005#

metaM glyald m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01051
name: D-glyceraldehyde
is: CHEBI:17378
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
type: Species
constant: false
has only substance units: false

metaR RE3628M
name: RE3628
fast: false
kinetic law: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
reversible: true
is: SBO:0000176
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:

metaR NDPK10
kinetic law: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
type: Reaction
is: SBO:0000176
product: MODEL1310110005#
reversible: true
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:dIDP)

metaR r2002
reactant: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_f7ce6f9b_2492_47dc_9d34_e50f0c8235f2
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:AI824319
boundary condition: true
is: SBO:0000252
name: _AI824319_1_r

metaM pect e
is: HMDB03402
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
name: pectins
initial amount: NaN
notes: FORMULA: C2535H3509O2535 CHARGE: -1
constant: false

metaR PRISTCOAtcx
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR r1639
is: SBO:0000185
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110005#
reversible: true

metaR r0408
reversible: true
reactant: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
is: SBO:0000176
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.4.3.5
fast: false
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
kinetic law: MODEL1310110005#
is described by: ECO:0000000

metaR r2095
type: Reaction
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
reactant: MODEL1310110005#
is described by: ECO:0000000
product: MODEL1310110005#

metaR GCHOLAtx
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110005#
type: Reaction
fast: false
kinetic law: MODEL1310110005#
is: SBO:0000185
name: bile acid intracellular transport
reversible: true
is described by: ECO:0000000

metaR KYNAKGAT
reversible: false
name: L-Kynurenine:2-oxoglutarate aminotransferase
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.6.1.7
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
fast: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
reactant: MODEL1310110005#

metaR r2360
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
fast: false
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport

metaM dlnlcgcoa c
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
name: dihomo-gamma-linolenyl coenzyme A
is: CHEBI:27979
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102

http://identifiers.org/biomodels.db/MODEL1310110005#_194373a5_0585_488d_a515_de620de155c1
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3029
has only substance units: false
name: HAGH
is: SBO:0000252
type: Species
is: Q16775

metaR CYOR u10m
is version of: http://identifiers.org/ec-code/1.2.1.3
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
product: MODEL1310110005#
is described by: ECO:0000134
modifier: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.92
kinetic law: MODEL1310110005#
name: ubiquinol-6 cytochrome c reductase, Complex III

metaR CYSSNAT5tc
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR RDH1
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.315
is described by: ECO:0000269
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
fast: false
type: Reaction
product: MODEL1310110005#
name: retinol dehydrogenase (all-trans)
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176

metaR NDPK7n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
is: SBO:0000176
reversible: true

metaR r0051
modifier: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
reversible: true
reactant: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
product: MODEL1310110005#

metaR ALDD2x
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
is: SBO:0000176
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.3
name: aldehyde dehydrogenase (acetaldehyde, NAD)
modifier: MODEL1310110005#
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_d1be4f30_7c21_4f68_ba7a_26cb95751364
type: Species
initial amount: NaN
is: Q9BXI2
boundary condition: true
constant: false
is encoded by: hsa:83884
name: SLC25A2
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR RE1531M
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE1531
product: MODEL1310110005#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true
type: Reaction
reactant: MODEL1310110005#

metaM dhlam m
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
has only substance units: false
is: HMDB00985
name: dihydrolipoamide
is: CHEBI:17694

metaR r0276
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110005#
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
product: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110005#
type: Reaction
modifier: MODEL1310110005#

metaM dchac e
name: deoxycholic acid
is: HMDB00626
initial concentration: 1.0
constant: false
notes: FORMULA: C24H39O4 CHARGE: -1
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247

metaM lnlc e
initial amount: NaN
is: CHEBI:30245
has only substance units: false
is: HMDB00673
is: SBO:0000247
name: linoleate
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
type: Species
constant: false

metaM pe hs m
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: SBO:0000247
has only substance units: false
name: phosphatidylethanolamine
constant: false
type: Species
is: CHEBI:16038
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR r2361
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
product: MODEL1310110005#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
type: Reaction
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false

metaR r2096
fast: false
modifier: MODEL1310110005#
reversible: true
reactant: MODEL1310110005#
is described by: ECO:0000000
product: MODEL1310110005#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r0407
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
reactant: MODEL1310110005#
reversible: true
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.3.5
product: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
is described by: ECO:0000000

metaR r2001
is described by: ECO:0000000
product: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
reactant: MODEL1310110005#

metaM orn e
initial amount: NaN
constant: false
name: Ornithine
is: HMDB00214
notes: FORMULA: C5H13N2O2 CHARGE: 1
has only substance units: false
initial concentration: 1.0
is: CHEBI:0
type: Species
is: C01602
is: SBO:0000247
boundary condition: false

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_0bfd0eb5_692e_4ba0_8da7_f9148dc8a836
is: SBO:0000252
type: Species
name: QPRT
is: Q15274
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:23475
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_a6dd5511_4b69_4d17_8c2a_0c24ec82b5f0
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: NT5C3
is: Q9H0P0
type: Species
is encoded by: hsa:51251
initial amount: NaN

metaM glyb c
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:17750
type: Species
is: SBO:0000247
name: glycine betaine
is: HMDB00043
initial amount: NaN

metaM anth e
has only substance units: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
initial amount: NaN
is: SBO:0000247
type: Species
name: anthranilate
is: CHEBI:16567
is: HMDB01123
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_869362a9_3a47_47b7_b3d0_6ad9938f1c4b
type: Species
has only substance units: false
boundary condition: true
is: P33897
is encoded by: hsa:215
constant: false
initial amount: NaN
initial concentration: NaN
name: ABCD1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_8e6efeec_e506_4e04_bd21_a2f70e51d84b
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:79071
type: Species
constant: false
is: Q9H5J4
initial amount: NaN
name: ELOVL6
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_218d256b_a9bd_46ad_a29f_ad1e9c61685b
is: Q8WWX8
constant: false
type: Species
initial concentration: NaN
name: SLC5A11
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:115584
boundary condition: true
has only substance units: false

metaM tmndnccoa m
is: SBO:0000247
constant: false
is: HMDB06514
has only substance units: false
name: timnodonyl coenzyme A
type: Species
initial amount: NaN
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_dc0f2a97_6898_4ae4_b7b6_ad8420ed0f11
initial concentration: NaN
constant: false
is encoded by: hsa:6390
has only substance units: false
is: P21912
name: SDHB
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR RE1516M
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
product: MODEL1310110005#
reversible: true
is described by: ECO:0000000
name: RE1516
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_481521e5_1dc3_4809_8630_2bd315bca9c7
boundary condition: true
initial concentration: NaN
is: P22352
constant: false
type: Species
has only substance units: false
name: GPX3
is encoded by: hsa:2878
is: SBO:0000252
initial amount: NaN

metaR HMGCOASim
type: Reaction
product: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.3.10
name: Hydroxymethylglutaryl CoA synthase (ir)
reversible: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
kinetic law: MODEL1310110005#
is described by: ECO:0000269
is: SBO:0000176

metaM HC02217 c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
constant: false
name: prostaglandin-g2
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial amount: NaN
has only substance units: false
is: CHEBI:27647

metaM o2 n
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01377
initial concentration: 1.0
type: Species
name: dioxygen
boundary condition: false
is: SBO:0000247
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

http://identifiers.org/biomodels.db/MODEL1310110005#_f4464c5b_1d37_428a_8faf_a5f62bd7a98f
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: HSD3B7
is encoded by: hsa:80270
is: SBO:0000252
is: Q9H2F3

metaR r0267
is version of: http://identifiers.org/ec-code/3.5.1.9
kinetic law: MODEL1310110005#
is: SBO:0000176
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
type: Reaction
reversible: true
is described by: ECO:0000000
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
modifier: MODEL1310110005#
reactant: MODEL1310110005#
fast: false

metaR DURIPP
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
reversible: true
fast: false
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.3
name: deoxyuridine phosphorylase
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#

metaM arachdcrn x
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5462164
is: SBO:0000247
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
is: HMDB01064
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_2eca659e_efa0_4f91_a583_ca8d217df38d
constant: false
type: Species
is: SBO:0000252
is: Q5JRA6
initial amount: NaN
has only substance units: false
is encoded by: hsa:375056
initial concentration: NaN
boundary condition: true
name: MIA3

metaM 3odcoa m
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
is: HMDB03939
name: 3-Oxodecanoyl-CoA
is: CHEBI:28528

metaM acnam c
has only substance units: false
type: Species
name: N-acetylneuraminate
boundary condition: false
is: CHEBI:35418
is: HMDB00230
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
initial concentration: 1.0

metaR r0829
is version of: http://identifiers.org/ec-code/4.1.1.37
fast: false
modifier: MODEL1310110005#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110005#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110005#
type: Reaction

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR GLNyLATthc
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glutamine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaM cit m
name: Citrate
is: HMDB00094
is: C00158
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:16947
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_7cbddae0_720f_4e26_a989_4e8da20bafc8
name: CMA1
is: Q4FEB3
initial amount: NaN
is encoded by: hsa:1215
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_dfad06f7_87ce_4ae7_a244_9c6e087868fc
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5831
type: Species
initial concentration: NaN
is: A6NFM2
boundary condition: true
has only substance units: false
constant: false
name: PYCR1

metaM o2 m
is: HMDB01377
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:15379
type: Species
is: C00007
name: O2

metaR r0268
reactant: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.1
product: MODEL1310110005#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
is: SBO:0000176
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: true
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.2

http://identifiers.org/biomodels.db/MODEL1310110005#_fa2ec387_7f66_4f72_9128_82ab4f3acd6e
name: _AA532636_1_m
initial amount: NaN
has only substance units: false
is encoded by: hsa:AA532636
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false

metaR RDH1a
is described by: ECO:0000269
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.300
modifier: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.105
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
name: retinol dehydrogenase (all-trans,NADPH)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_3708d4ca_957d_406a_9ed8_f500833bd66e
has only substance units: false
initial amount: NaN
name: VNN1
boundary condition: true
is encoded by: hsa:8876
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is: O95497

metaR r1659
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000000

metaR RE3556C
reversible: true
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000176
type: Reaction
fast: false
name: RE3556
is described by: ECO:0000000

metaR OCDCEAtr
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185
fast: false
type: Reaction
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110005#_8f910ba5_7ac1_49d5_b261_733e9a108c44
boundary condition: true
has only substance units: false
type: Species
name: SLC23A1
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9963

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_3050c7a7_1796_4499_bf35_0bfceab36358
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:NM 001929
initial amount: NaN
name: _NM_001929_1_c
constant: false
initial concentration: NaN
is: SBO:0000252

metaR DURAD
fast: false
kinetic law: MODEL1310110005#
name: dihydrouracil dehydrogenase (NADP)
is version of: http://identifiers.org/ec-code/1.3.1.2
is described by: ECO:0000269
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
type: Reaction
reversible: true
product: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000176

metaM HC02217 e
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
name: prostaglandin-g2
initial amount: NaN
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: CHEBI:27647
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_c1f227d9_105e_4dc5_b26b_a986242cc23e
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:4907
type: Species
is: P21589
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: NT5E

http://identifiers.org/biomodels.db/MODEL1310110005#_6e94a1ed_2b07_4ac6_9a8e_163b63c8b08d
is encoded by: hsa:6576
is: SBO:0000252
name: SLC25A1
is: D9HTE9
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

metaM zymst r
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
name: zymosterol
has only substance units: false
initial concentration: 1.0
is: CHEBI:18252
is: HMDB06271
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_47e0612a_b209_48b6_beec_799c85d55280
is: SBO:0000252
initial concentration: NaN
constant: false
name: _AL048840_1_c
has only substance units: false
initial amount: NaN
is encoded by: hsa:AL048840
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_8b463760_3f67_4edc_931c_c87dfb333a1f
initial concentration: NaN
name: PTGDS
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:5730
constant: false
is: P41222
initial amount: NaN
boundary condition: true

metaR ABTD
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
fast: false
product: MODEL1310110005#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
is: SBO:0000176
name: L-arabinitol 4-dehydrogenase

metaR MTHFDm
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
modifier: MODEL1310110005#
fast: false
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/6.3.4.3
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000269
type: Reaction
reversible: true
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000176

metaR NRPPHRt4 2 r
product: MODEL1310110005#
name: Norepinephrine reversible transport in via sodium symport (1:2)
is: SBO:0000185
fast: false
modifier: MODEL1310110005#
reversible: true
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaR LYSOXp
reversible: false
is: SBO:0000176
name: L-lysine oxidase, peroxisomal
product: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
is described by: ECO:0000000
kinetic law: MODEL1310110005#
type: Reaction

metaR LACZe
is version of: http://identifiers.org/ec-code/3.2.1.108
reversible: false
modifier: MODEL1310110005#
is described by: ECO:0000134
product: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase
reactant: MODEL1310110005#
name: b-galactosidase, extracellular
kinetic law: MODEL1310110005#
type: Reaction
fast: false

metaR GLXtp
reversible: true
kinetic law: MODEL1310110005#
fast: false
name: glyoxylate transport, peroxisomal
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110005#
product: MODEL1310110005#

metaM xol7ah2 c
is: SBO:0000247
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
initial concentration: 1.0
boundary condition: false
constant: false
name: 5beta-cholestane-3alpha,7alpha-diol
is: HMDB06893
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:28047

metaR MGSA2
fast: false
is: SBO:0000176
product: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
name: methyglyoxylate synthase 2 (from g3p)
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:this rxn also represents the enzymatic conversion or non-enzymatic fragmentation of g3p to mthgxl - NCD
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_8abbfa80_dffa_4ddd_8b81_58643a0b318b
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: F5GY65
has only substance units: false
name: SLC25A11
is encoded by: hsa:8402
initial concentration: NaN
constant: false

metaR r0774
product: MODEL1310110005#
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
kinetic law: MODEL1310110005#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
modifier: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
reactant: MODEL1310110005#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107

metaR NCKt
modifier: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
name: Na+/Ca2+-K+ exchange
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110005#
is described by: ECO:0000269
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaM cytd m
name: cytidine
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
constant: false
initial amount: NaN
is: CHEBI:17562
is: HMDB00089
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_4fe2bf3d_c4cb_4bec_8ac4_98030896897c
name: LDHA:LDHB
is encoded by: hsa:3945
initial amount: NaN
initial concentration: NaN
has part: P00338
is: SBO:0000297
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:3939
type: Species
has part: P07195

metaR CMPACNAtn
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
name: CMP-Sia nuclear export
fast: false
kinetic law: MODEL1310110005#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_fa2ec4e2_356a_4374_af5f_8d0e2e50819a
is: Q9HBF5
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:400410
name: ST20

metaM dcacoa m
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
initial concentration: 1.0
is: C05274
constant: false
name: Decanoyl-CoA (n-C10:0CoA)
is: CHEBI:61430
is: HMDB06404

metaR BUTt2r
product: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
is described by: ECO:0000269
modifier: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:JLR
type: Reaction
name: Butyrate transport via proton symport, reversible
fast: false
reactant: MODEL1310110005#

metaM CE4792 m
initial concentration: 1.0
is: CHEBI:12947
has only substance units: false
constant: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
type: Species
boundary condition: false
initial amount: NaN
name: 3-oxo-cis-8-tetradecenoyl-CoA
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_53ec8875_376a_441d_960e_1c1623c00864
boundary condition: true
is: Q86V21
is encoded by: hsa:65985
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
name: AACS
initial concentration: NaN

metaR r1656
product: MODEL1310110005#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dhbpt c
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: HMDB00038
type: Species
initial amount: NaN
name: 6,7-dihydrobiopterin
initial concentration: 1.0
is: CHEBI:20680
boundary condition: false
constant: false
is: SBO:0000247

metaR r0552
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.3.5.1
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
product: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
type: Reaction
fast: false
is: SBO:0000176

metaM dpcoa m
type: Species
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial concentration: 1.0
is: HMDB01373
name: 3'-dephospho-CoA(2-)
is: CHEBI:57328

metaM dump n
is: HMDB01409
constant: false
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:246422
boundary condition: false
initial concentration: 1.0
name: dUMP(2-)
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365

http://identifiers.org/biomodels.db/MODEL1310110005#_34592ea9_b21a_492a_8d19_17d88033046a
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: P07864
has only substance units: false
is encoded by: hsa:3948
is: SBO:0000252
initial amount: NaN
name: LDHC

http://identifiers.org/biomodels.db/MODEL1310110005#_53269ce3_df35_49f6_b000_e99b07940e45
is encoded by: hsa:MBOAT5
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
name: _MBOAT5_1_c
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_76d827a8_b90d_400d_8068_dd7929a09c8f
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2879
name: GPX4
is: P36969
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_9e681479_6155_4d19_be85_0b6caf38f4cd
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is: Q5FWE9
constant: false
has only substance units: false
is encoded by: hsa:134526
name: ACOT12
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_dae9d6a3_0d98_4581_ad04_19050c24754c
name: SDS
initial amount: NaN
type: Species
is: P20132
is encoded by: hsa:10993
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR r1655
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaM dump m
is: HMDB01409
initial amount: NaN
is: CHEBI:246422
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: dUMP(2-)
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365

http://identifiers.org/biomodels.db/MODEL1310110005#_19ab2cc6_7c6f_470a_9ad7_8fe30dbced85
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q86YU0
constant: false
initial concentration: NaN
name: CA7
initial amount: NaN
is encoded by: hsa:766

metaM his L m
initial amount: NaN
is: HMDB00177
name: L-histidine
boundary condition: false
constant: false
is: CHEBI:15971
initial concentration: 1.0
type: Species
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
has only substance units: false
is: SBO:0000247

metaR r0553
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
fast: false
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
product: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
type: Reaction
is: SBO:0000176

metaR r0400
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
fast: false
modifier: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
reversible: true
product: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.4

metaM ficytC m
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
is: CHEBI:15991
name: Ferricytochrome c
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false

metaM prostgh2 r
name: prostaglandin H2(1-)
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57405
is: SBO:0000247
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
is: HMDB01381
has only substance units: false
constant: false

metaM HC01444 e
initial concentration: 1.0
has only substance units: false
name: Galactosylglycerol
is: SBO:0000247
is: CHEBI:15754
type: Species
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401

metaR r0494
kinetic law: MODEL1310110005#
is: SBO:0000176
product: MODEL1310110005#
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
reactant: MODEL1310110005#
fast: false
is described by: ECO:0000000

metaM prostgf2 c
is: SBO:0000247
name: prostaglandin F2alpha(1-)
initial concentration: 1.0
initial amount: NaN
is: HMDB01139
type: Species
is: CHEBI:57404
has only substance units: false
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
constant: false

metaR PUNP1
modifier: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
reversible: true
product: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
kinetic law: MODEL1310110005#
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Adenosine)
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase

metaR ARACHDt2
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
name: fatty acid transport via diffusion
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110005#
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_785086d6_a0c4_486e_9c4b_a7f8783afbef
is encoded by: hsa:28232
is: Q9UIG8
name: SLCO3A1
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

metaR EX c4crn
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaM itaccoa m
type: Species
boundary condition: false
is: CHEBI:57381
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
name: itaconyl-CoA(5-)
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB03377

metaR r0779
type: Reaction
reactant: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
is: SBO:0000176
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
reversible: false

metaR r2501
is: SBO:0000185
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#
fast: false
reversible: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
is described by: ECO:0000000
type: Reaction

metaR CYTK12n
reversible: true
is: SBO:0000176
modifier: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
fast: false
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dCTP),nuclear
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_6a2cba2e_f8e3_4a43_8d03_db0a50868891
is: SBO:0000252
type: Species
initial concentration: NaN
name: NME7
boundary condition: true
constant: false
is encoded by: hsa:29922
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_f1b1314c_5f5b_42f7_be4b_44fd9a58cde7
has only substance units: false
boundary condition: true
name: SLC6A9
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:6536
is: P48067
is: SBO:0000252

metaR r1658
kinetic law: MODEL1310110005#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
product: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_a04e90ec_cac0_4a07_9070_b845d397c20f
name: SLC24A4
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:123041
initial concentration: NaN
boundary condition: true
type: Species

metaR r1657
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110005#
fast: false
is: SBO:0000185
modifier: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
reversible: true

metaR PUNP2
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110005#
reversible: true
product: MODEL1310110005#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Deoxyadenosine)
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110005#

metaR 13DAMPPOX
is described by: ECO:0000212
kinetic law: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.21
modifier: MODEL1310110005#
product: MODEL1310110005#
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
is: SBO:0000176
reactant: MODEL1310110005#

metaR MALSO3tm
kinetic law: MODEL1310110005#
is described by: ECO:0000269
product: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reactant: MODEL1310110005#
is: SBO:0000185
modifier: MODEL1310110005#
type: Reaction
name: Malate:sulfite antiport, mitochondrial
reversible: true

metaR TRIODTHYt2
kinetic law: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
is described by: ECO:0000269
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is: SBO:0000185
name: T3 transport via facilitated diffusion
fast: false
modifier: MODEL1310110005#
reversible: true

metaR EX udpgal LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UDP-D-galactose(2-) exchange
type: Reaction

metaR SERGLNexR
modifier: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
name: L-Serine/Glutamine reversible exchange
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110005#
reversible: true
product: MODEL1310110005#
is described by: ECO:0000304
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_d0573ce8_61cc_41f1_ae62_4b63747aecdb
initial amount: NaN
name: STS
constant: false
type: Species
is encoded by: hsa:412
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P08842
is: SBO:0000252

metaM xol7ah2 m
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB06893
is: CHEBI:28047
name: 5beta-cholestane-3alpha,7alpha-diol
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_fc2295d7_eadf_4101_a248_f46ab22b9eb4
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _AA977580_1_c
type: Species
is: SBO:0000252
is encoded by: hsa:AA977580
constant: false

metaR SARDHm
name: Sarcosine dehydrogenase (m)
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
type: Reaction
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.5.99.1
kinetic law: MODEL1310110005#
reversible: false
modifier: MODEL1310110005#
fast: false
product: MODEL1310110005#

metaR r1015
name: Na(+)/bile acid cotransporter Active transport
reactant: MODEL1310110005#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:6469982 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110005#
type: Reaction
product: MODEL1310110005#

metaM dhcholestanate c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB00359
type: Species
constant: false
is: CHEBI:16577
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: SBO:0000247
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR GTHRDt
is: SBO:0000185
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
product: MODEL1310110005#
reversible: true
is described by: ECO:0000000
name: Glutathione transport into mitochondria
reactant: MODEL1310110005#
fast: false
type: Reaction

metaM hLkynr c
boundary condition: false
name: 3-hydroxy-L-kynurenine
has only substance units: false
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
initial amount: NaN
type: Species
is: CHEBI:17380
constant: false
is: SBO:0000247
is: HMDB11631
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_99574384_6657_4b9e_824d_7573b4eb5600
initial amount: NaN
is: Q6NVY1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:26275
has only substance units: false
type: Species
boundary condition: true
constant: false
name: HIBCH

http://identifiers.org/biomodels.db/MODEL1310110005#_93b2ee0c_1ec7_48c1_88dd_e4de6f93996d
is: F8VQS7
initial concentration: NaN
constant: false
is encoded by: hsa:55967
name: NDUFA12
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR r0556
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.14.19.1
type: Reaction
modifier: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000176
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61

metaR r1652
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110005#
fast: false

metaR ALAyLATthc
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Alanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaM tcynt c
initial concentration: 1.0
type: Species
name: thiocyanate
is: CHEBI:18022
is: HMDB01453
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755

metaR r1578
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_10a6b245_d0d4_4d9d_85cf_e646e59dfd54
is: P56556
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4700
name: NDUFA6

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaR FTHFL
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000134
reversible: true
name: Formate-tetrahydrofolate ligase
is version of: http://identifiers.org/ec-code/1.5.1.5
is: SBO:0000176
type: Reaction

metaM triodthy e
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial amount: NaN
constant: false
is: SBO:0000247
name: 3,3',5-triiodo-L-thyronine
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:18258
is: HMDB00265
has only substance units: false

metaR LEUKTRD4t
product: MODEL1310110005#
is described by: ECO:0000269
reversible: true
type: Reaction
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
fast: false
name: leukotriene D4 transport

http://identifiers.org/biomodels.db/MODEL1310110005#_8d57ee84_deda_4b76_ba55_5b001980712b
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4714
initial concentration: NaN
initial amount: NaN
name: NDUFB8
boundary condition: true
type: Species
is: O95169

metaM 4hglusa m
initial concentration: 1.0
is: HMDB06556
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
name: L-4-hydroxyglutamic semialdehyde
has only substance units: false
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
is: CHEBI:27809
constant: false

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaR r0557
product: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:9620315 NOTES:
type: Reaction
fast: false
reactant: MODEL1310110005#
is: SBO:0000176
reversible: false
name: Glutaryl-CoA:dihydrolipoamide S-succinyltransferase Lysine degradation EC:2.3.1.61

metaR r1651
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110005#
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM cit e
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
is: SBO:0000247
initial amount: NaN
name: citrate(3-)
is: CHEBI:16947
initial concentration: 1.0
type: Species

metaR r1579
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
type: Reaction

metaR RE3421R
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110005#
name: RE3421
is: SBO:0000176
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
reversible: true
product: MODEL1310110005#

metaM dudp c
initial concentration: 1.0
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
type: Species
initial amount: NaN
boundary condition: false
is: C01346
is: HMDB01000
has only substance units: false
is: CHEBI:60471
name: dUDP
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_7b113d95_209d_489e_86d8_17d0043fa715
name: EBP
is: Q15125
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:10682
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_f959bfc4_be03_4593_b5d6_58383d3c15a5
boundary condition: true
type: Species
name: CPT2
constant: false
is encoded by: hsa:1376
is: SBO:0000252
has only substance units: false
is: P23786
initial concentration: NaN
initial amount: NaN

metaM cytd e
has only substance units: false
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: SBO:0000247
is: C00475
constant: false
is: CHEBI:17562
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: Cytidine
is: HMDB00089

http://identifiers.org/biomodels.db/MODEL1310110005#_26dcae10_392d_427d_bdb4_d0902b49e2f2
constant: false
is: SBO:0000252
name: PC
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5091
type: Species
has only substance units: false
initial amount: NaN
is: P11498

metaR CYTK14
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110005#
type: Reaction
fast: false
modifier: MODEL1310110005#
is described by: ECO:0000269
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,UTP)

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_eb0e76de_6798_4ff8_94a3_39c913cee85d
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: FOLR3
is encoded by: hsa:2352
type: Species
is: Q05C14
is: SBO:0000252
constant: false
has only substance units: false

metaR r1654
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
is: SBO:0000185
fast: false
modifier: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#

metaR CYSTA
is described by: ECO:0000304
fast: false
type: Reaction
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
reversible: true
product: MODEL1310110005#
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
name: cysteine transaminase

http://identifiers.org/biomodels.db/MODEL1310110005#_13bb82fb_905c_4e1d_b133_f2a7f3c290fd
constant: false
initial concentration: NaN
name: SLC4A8
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:9498
is: SBO:0000252
is: E7EML0

metaR NAIt
reactant: MODEL1310110005#
name: Na+ / iodide cotransport
modifier: MODEL1310110005#
is described by: ECO:0000269
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
fast: false

metaM tcynt e
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
type: Species
initial concentration: 1.0
is: CHEBI:18022
is: HMDB01453
name: thiocyanate
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false

metaR r1428
fast: false
type: Reaction
reversible: true
product: MODEL1310110005#
name: Free diffusion
reactant: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
kinetic law: MODEL1310110005#
is described by: ECO:0000000

metaR CYTK13
product: MODEL1310110005#
is described by: ECO:0000269
kinetic law: MODEL1310110005#
name: cytidylate kinase (dCMP,dATP)
reactant: MODEL1310110005#
is: SBO:0000176
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_d412bbfd_928f_4811_8964_0ade878fe281
constant: false
is: SBO:0000252
initial concentration: NaN
name: IDH2
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:3418
initial amount: NaN
is: P48735

metaM dpcoa l
name: 3'-dephospho-CoA(2-)
initial amount: NaN
type: Species
constant: false
is: HMDB01373
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: CHEBI:57328
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_fda47944_9390_450c_acce_ee61f831910f
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:AI656480
initial amount: NaN
name: _AI656480_1_m
type: Species
initial concentration: NaN
has only substance units: false

metaM triodthy c
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
name: 3,3',5-triiodo-L-thyronine
initial amount: NaN
is: HMDB00265
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial concentration: 1.0
is: CHEBI:18258
constant: false

metaM cys L e
name: L-cysteine
type: Species
is: CHEBI:17561
initial concentration: 1.0
constant: false
is: HMDB00574
boundary condition: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_85890759_ccfd_4dbd_b75e_4a49c1dbf28c
has only substance units: false
is: SBO:0000252
is encoded by: hsa:64087
boundary condition: true
initial concentration: NaN
name: MCCC2
constant: false
type: Species
initial amount: NaN
is: Q9HCC0

http://identifiers.org/biomodels.db/MODEL1310110005#_9d09b748_fb83_4971_b087_d45cc3fe74ba
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: XDH
initial amount: NaN
is encoded by: hsa:7498
type: Species
is: P47989
has only substance units: false

metaR RE1860E
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.1.4.37
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
reversible: true
name: RE1860
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (1267.1) SUBSYSTEM: Miscellaneous EC Number: 3.1.4.37 Confidence Level: 0 AUTHORS: PMID:12225906 NOTES:

metaM spmd c
boundary condition: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: CHEBI:57834
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
name: Spermidine
is: C00315
has only substance units: false
is: HMDB01257
constant: false

metaM lnlc r
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
is: HMDB00673
has only substance units: false
is: CHEBI:30245
initial amount: NaN
type: Species
name: linoleate

http://identifiers.org/biomodels.db/MODEL1310110005#_86e29f1d_6c30_4ef2_b20a_52ffa646de9f
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P14618
is: SBO:0000252
is encoded by: hsa:5315
constant: false
has only substance units: false
name: PKM2
type: Species

metaR r1653
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
modifier: MODEL1310110005#

metaR PHETHPTOX2
is: SBO:0000176
product: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
notes: GENE_ASSOCIATION: (5053.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.14.16.1 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:9450897 NOTES:SAB unlumped form of PHETHPTOX according to PMID 10727395
reactant: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/1.14.16.1
modifier: MODEL1310110005#
type: Reaction
is described by: ECO:0000269

metaM cytd c
initial amount: NaN
constant: false
is: CHEBI:17562
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: C00475
is: HMDB00089
is: SBO:0000247
name: Cytidine
boundary condition: false

metaR O2St
name: superoxide anion transport via diffusion (extracellular)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110005#
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110005#
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_a8ab1ca2_69bc_48d2_80c0_b52a60a95322
constant: false
initial amount: NaN
is: P07195
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3945
initial concentration: NaN
boundary condition: true
name: LDHB
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_d2f39959_68eb_47de_b1e4_e963daf8c869
initial concentration: NaN
initial amount: NaN
type: Species
name: PRPS1L1
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:221823

http://identifiers.org/biomodels.db/MODEL1310110005#_b08624cd_f5be_42a9_981c_ac24d88d855b
boundary condition: true
name: SOD1
is: P00441
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6647
initial concentration: NaN
constant: false

metaR CYTK12
is described by: ECO:0000269
type: Reaction
reversible: true
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dCTP)
modifier: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_65dd1fb4_4158_4ad7_87ae_ce0838e52fe4
type: Species
boundary condition: true
is encoded by: hsa:4831
initial concentration: NaN
is: SBO:0000252
name: NME2
initial amount: NaN
has only substance units: false
constant: false
is: P22392

metaR r1429
kinetic law: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110005#
product: MODEL1310110005#
name: Free diffusion

metaM dpcoa e
initial concentration: 1.0
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
is: HMDB01373
is: CHEBI:57328
type: Species
name: Dephospho-CoA
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C00882

metaM HC00342 m
constant: false
name: cis-aconitate(3-)
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16383
initial amount: NaN
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417

metaM accoa n
name: acetyl-CoA(4-)
has only substance units: false
is: CHEBI:57288
initial amount: NaN
is: HMDB01206
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
type: Species

metaR r1574
reversible: true
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR r2507
fast: false
is: SBO:0000185
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
name: Utilized transport

metaR GLXtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
name: glyoxylate transport, mitochondrial
is: SBO:0000185
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction

metaM udpg c
is: C00029
has only substance units: false
type: Species
is: HMDB00286
name: UDPglucose
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58367
initial amount: NaN
constant: false
boundary condition: false

metaM cys L c
is: HMDB00574
initial concentration: 1.0
type: Species
has only substance units: false
name: L-cysteine
is: SBO:0000247
constant: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: CHEBI:17561
initial amount: NaN
boundary condition: false

metaM xan c
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
is: SBO:0000247
is: CHEBI:17712
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00385
name: Xanthine
is: HMDB00292
constant: false
has only substance units: false
type: Species

metaR FAOXC160
kinetic law: MODEL1310110005#
name: Beta oxidation of long chain fatty acid
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
modifier: MODEL1310110005#
is described by: ECO:0000269
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110005#

metaR LCADi
is described by: ECO:0000304
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
product: MODEL1310110005#
name: lactaldehyde dehydrogenase
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
kinetic law: MODEL1310110005#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_baca524d_976e_44e7_ad98_634b2545bb18
is encoded by: hsa:22978
has only substance units: false
is: P49902
initial concentration: NaN
name: NT5C2
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_a68e5202_c79b_4804_aa66_c93fc7f8ec71
is encoded by: hsa:30
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: Q96CA6
type: Species
name: ACAA1
is: SBO:0000252
has only substance units: false

metaR CYTK11
reactant: MODEL1310110005#
is described by: ECO:0000269
kinetic law: MODEL1310110005#
name: cytidylate kinase (dCMP,dGTP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110005#
fast: false
type: Reaction

metaR RE3003M
fast: false
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/5.3.3.8
name: RE3003
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110005#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaM o2 r
is: CHEBI:15379
is: C00007
constant: false
is: SBO:0000247
name: O2
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false
boundary condition: false
is: HMDB01377

http://identifiers.org/biomodels.db/MODEL1310110005#_a19bd0d6_ce4d_4d90_ac23_4204d5b9f342
is encoded by: hsa:126
type: Species
name: ADH1B:ADH1C
initial concentration: NaN
has only substance units: false
is: SBO:0000297
initial amount: NaN
constant: false
boundary condition: true
has part: P00326

metaM his L e
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
name: L-histidine
initial amount: NaN
is: CHEBI:15971
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: SBO:0000247
constant: false
is: HMDB00177

metaM arachd r
is: SBO:0000247
constant: false
is: CHEBI:32395
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
name: arachidonate
type: Species
is: HMDB01043

metaM k e
is: SBO:0000247
is: CHEBI:29103
has only substance units: false
initial concentration: 1.0
name: potassium
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial amount: NaN
is: HMDB00586
type: Species
constant: false
boundary condition: false
is: C00238

metaR r1575
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR r2506
name: Utilized transport
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reversible: true
reactant: MODEL1310110005#
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_55ed691b_5b5f_4d1f_8a90_60de71525d81
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is: Q53H96
is encoded by: hsa:65263
has only substance units: false
name: PYCRL
constant: false
is: SBO:0000252

metaM spmd e
type: Species
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
is: CHEBI:57834
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: Spermidine
is: C00315
is: HMDB01257
constant: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_2f44a28e_fdbc_493e_9df1_7687d95ee374
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: PRDX1
is encoded by: hsa:5052
initial amount: NaN
type: Species

metaR DTDPtn
is described by: ECO:0000000
name: dTDP nuclear transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
fast: false
type: Reaction
product: MODEL1310110005#

metaR DADA
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
is version of: http://identifiers.org/ec-code/3.5.4.4
type: Reaction
product: MODEL1310110005#
reactant: MODEL1310110005#
reversible: false
name: Deoxyadenosine deaminase
modifier: MODEL1310110005#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110005#
is: SBO:0000176

metaR FAOXC226205m
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110005#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR r0558
modifier: MODEL1310110005#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110005#_0b21bbf6_3431_4c32_8b21_441951b48d4c
is: SBO:0000252
is encoded by: hsa:9962
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: Q9UGH3
name: SLC23A2
initial concentration: NaN

metaR 3HCO3 NAt
reversible: true
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
name: 3HCO3_NAt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
is described by: ECO:0000134
is: SBO:0000185
fast: false

metaR CYTK10
reversible: true
product: MODEL1310110005#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
name: cytidylate kinase (CMP,dGTP)
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110005#_58f0631d_684b_4581_9385_48ac7348f1b5
type: Species
is: SBO:0000252
name: CRAT
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:1384

metaR r1576
reactant: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185

metaR RE1807C
reactant: MODEL1310110005#
fast: false
type: Reaction
product: MODEL1310110005#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE1807

metaM lgt S c
has only substance units: false
is: HMDB01066
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
type: Species
is: CHEBI:57474
initial concentration: 1.0
boundary condition: false
name: (R)-S-lactoylglutathionate(1-)

metaM HC01407 m
has only substance units: false
constant: false
is: CHEBI:28276
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
name: (S)-Hydroxyhexanoyl-CoA
initial concentration: 1.0
boundary condition: false

metaR r1650
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110005#
fast: false

metaR CHAT
is: SBO:0000176
modifier: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
product: MODEL1310110005#
is described by: ECO:0000269
name: Choline O-acetyltransferase
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.6

http://identifiers.org/biomodels.db/MODEL1310110005#_0d6d162e_30e0_43cb_ab3c_bc18e8a1a086
type: Species
name: QDPR
is: P09417
has only substance units: false
is encoded by: hsa:5860
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_f25cb1ac_828e_4afe_a2eb_8142207167d0
is: SBO:0000252
is encoded by: hsa:3032
boundary condition: true
is: P55084
name: HADHB
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_4b36da74_fb8f_4434_aeab_06c71327a2fa
boundary condition: true
constant: false
is encoded by: hsa:4719
initial amount: NaN
type: Species
is: P28331
has only substance units: false
name: NDUFS1
is: SBO:0000252
initial concentration: NaN

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_cdc6ba3d_3753_4b4d_972b_e1b16fd6364d
is encoded by: hsa:9197
initial amount: NaN
is: O00400
type: Species
has only substance units: false
name: SLC33A1
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true

metaR r0559
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
kinetic law: MODEL1310110005#
is: SBO:0000176
product: MODEL1310110005#
fast: false

metaR r1010
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
name: Postulated transport reaction
is described by: ECO:0000000
kinetic law: MODEL1310110005#

metaM HC01522 c
constant: false
initial concentration: 1.0
is: CHEBI:28508
boundary condition: false
has only substance units: false
is: SBO:0000247
name: Gentisate aldehyde
type: Species
initial amount: NaN
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585

http://identifiers.org/biomodels.db/MODEL1310110005#_78e51c3d_2610_43f8_ade0_a0549623c0fb
has only substance units: false
initial concentration: NaN
is: Q02218
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: OGDH
is encoded by: hsa:4967
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_feee33bd_7726_4e97_a7d4_fb906e17a196
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:51109
name: RDH11
is: B4DDW0

metaM accoa m
name: Acetyl-CoA
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01206
constant: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: C00024
is: CHEBI:57288
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_83f50e45_8a09_4869_bd9f_c36ae85494f4
is: SBO:0000252
name: MTHFD1L
boundary condition: true
is encoded by: hsa:25902
type: Species
constant: false
has only substance units: false
is: B2RD24
initial amount: NaN
initial concentration: NaN

metaM gal e
initial concentration: 1.0
type: Species
is: HMDB00143
is: CHEBI:0
name: D-Galactose
is: SBO:0000247
initial amount: NaN
is: C00124
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0

metaM his L c
constant: false
initial concentration: 1.0
is: HMDB00177
has only substance units: false
name: L-histidine
type: Species
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaM k c
has only substance units: false
constant: false
is: C00238
is: CHEBI:29103
is: SBO:0000247
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial concentration: 1.0
name: potassium
initial amount: NaN
is: HMDB00586
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_1a15e187_faa1_4d6b_b01a_be06a78a07d7
constant: false
is encoded by: hsa:64850
initial amount: NaN
type: Species
name: AGXT2L1
has only substance units: false
is: SBO:0000252
is: Q8TBG4
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_90399c0f_7953_4818_bdfc_ed3d4cd405a5
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI934540
name: _AI934540_1_c
boundary condition: true
is: SBO:0000252

metaR r2508
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
reactant: MODEL1310110005#
is: SBO:0000185
type: Reaction
product: MODEL1310110005#
fast: false
reversible: true
kinetic law: MODEL1310110005#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_c1b8b30f_52a1_49cd_af0f_0fe98e920635
initial amount: NaN
name: MCCC1:MCCC2
has part: Q9HCC0
has part: Q96RQ3
boundary condition: true
is encoded by: hsa:64087
initial concentration: NaN
is encoded by: hsa:56922
has only substance units: false
constant: false
is: SBO:0000297
type: Species

metaR RE0926E
name: RE0926
reversible: true
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110005#

metaR r1571
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110005#
fast: false
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_a4ffaded_e0e5_4f08_871c_ff6cf1eb673a
has only substance units: false
is: SBO:0000252
name: CHAT
is encoded by: hsa:1103
type: Species
initial amount: NaN
is: Q6LEN5
constant: false
boundary condition: true
initial concentration: NaN

metaR r0196
fast: false
reversible: true
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110005#
modifier: MODEL1310110005#

metaR GLYtp
is described by: ECO:0000000
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
name: glycine passive transport to peroxisome
type: Reaction
reactant: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
reversible: true

metaR UMPK2n
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
reversible: true
name: UMP kinase (CTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is: SBO:0000176
modifier: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110005#_3bae40c6_0dbf_4204_acd3_d737babe4f33
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:131
is: P40394
name: ADH7

metaM pail hs c
initial amount: NaN
is: CHEBI:57880
initial concentration: 1.0
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
type: Species
name: 1-phosphatidyl-1D-myo-inositol(1-)

metaM chsterol l
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: cholesterol
constant: false
is: HMDB00067
boundary condition: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: CHEBI:16113

http://identifiers.org/biomodels.db/MODEL1310110005#_401d062b_15ef_41b1_91b7_d7b79cae54ce
boundary condition: true
type: Species
is: P49753
is encoded by: hsa:10965
constant: false
has only substance units: false
is: SBO:0000252
name: ACOT2
initial amount: NaN
initial concentration: NaN

metaR RE1810M
fast: false
kinetic law: MODEL1310110005#
name: RE1810
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
product: MODEL1310110005#

metaM gltcho e
type: Species
is: C02862
name: beta glucan-taurocholic acid complex
initial concentration: 1.0
notes: FORMULA: C1200026H2200045NO1100007S CHARGE: 0
is: HMDB02013
is: http://identifiers.org/pubchem.compound/213144
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false

metaR r2352
reactant: MODEL1310110005#
is: SBO:0000185
fast: false
product: MODEL1310110005#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110005#
reversible: true

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaR r1570
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_5a7913fa_b4d0_4aa3_8f62_34933a4b077a
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:27034
has only substance units: false
name: ACAD8
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: Q6ZWP6

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR MCLOR
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.27
type: Reaction
name: 3-Mercaptolactate:NAD+ oxidoreductase
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110005#_79febdc1_b5b6_4990_984d_63727199f890
constant: false
name: ACSL5
is encoded by: hsa:51703
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is: Q9ULC5
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_51ef6313_0a1c_4f3d_84c9_50a5253f8cf4
type: Species
is encoded by: hsa:4704
initial amount: NaN
is: Q16795
name: NDUFA9
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

metaR ME1m
is version of: http://identifiers.org/ec-code/1.1.1.38
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
is: SBO:0000176
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (4200.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: NOTES:NCD
name: malic enzyme (NAD), mitochondrial
modifier: MODEL1310110005#
is described by: ECO:0000000

metaM chsterol m
is: CHEBI:16113
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial concentration: 1.0
name: cholesterol
type: Species
is: HMDB00067
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_56ded794_65fa_4921_9e45_e6e9ff3cb527
constant: false
initial concentration: NaN
name: NT5M
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:56953
boundary condition: true
is: SBO:0000252
is: Q9NPB1

http://identifiers.org/biomodels.db/MODEL1310110005#_3aaf371d_c7b1_4bb6_9af8_86d95cbe1e28
boundary condition: true
name: _N63787_1_c
type: Species
is: SBO:0000252
is encoded by: hsa:N63787
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaR RE3346C
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
fast: false
modifier: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
name: RE3346
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110005#
is: SBO:0000176

metaR PSERT
fast: false
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
reactant: MODEL1310110005#
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.52
product: MODEL1310110005#
kinetic law: MODEL1310110005#
name: phosphoserine transaminase
is: SBO:0000176
modifier: MODEL1310110005#
type: Reaction
is described by: ECO:0000269

metaR CTPtn
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
product: MODEL1310110005#
name: CTP diffusion in nucleus
reversible: true

metaR PRPPS
is: SBO:0000176
product: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/2.7.6.1
name: phosphoribosylpyrophosphate synthetase
modifier: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110005#
reversible: true

metaR r2353
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110005#
is: SBO:0000185
fast: false
name: Organic anion transporter 5 Utilized transport
reversible: true
reactant: MODEL1310110005#
product: MODEL1310110005#

metaR r0616
kinetic law: MODEL1310110005#
product: MODEL1310110005#
fast: false
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
modifier: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
type: Reaction
is: SBO:0000176

metaR GK1
name: guanylate kinase (GMP:ATP)
reactant: MODEL1310110005#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.8
modifier: MODEL1310110005#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_ae83cc68_a940_42a0_bd95_d1d5491625fd
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: NME7
is: Q9Y5B8
type: Species
constant: false
is encoded by: hsa:29922

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_1bb7d7fb_9fc7_4a4d_b125_658fbd42c924
type: Species
name: _LOC647190_1_c
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:LOC647190
is: SBO:0000252

metaR ACt2r
is: SBO:0000185
name: acetate reversible transport via proton symport
fast: false
reactant: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
kinetic law: MODEL1310110005#
product: MODEL1310110005#

metaR r0941
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110005#
name: Free diffusion
is: SBO:0000185
reversible: true
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_ac08f166_bd59_468b_9f16_13173ceaf286
is: O14556
name: GAPDHS
type: Species
is encoded by: hsa:26330
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaM cholcoa c
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:57373
has only substance units: false
initial concentration: 1.0
is: HMDB01374
constant: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
name: choloyl-CoA(4-)
boundary condition: false

metaM dpcoa c
initial concentration: 1.0
type: Species
is: CHEBI:57328
constant: false
name: Dephospho-CoA
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB01373
boundary condition: false
is: C00882
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882

metaR LGTHL
reactant: MODEL1310110005#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#
reversible: false
name: lactoylglutathione lyase
is version of: http://identifiers.org/ec-code/4.4.1.5
is: SBO:0000176

metaR MMSAD1m
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
reactant: MODEL1310110005#
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.27
name: methylmalonate-semialdehyde dehydrogenase
fast: false

metaM dmnoncoa x
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
name: 4,8 dimethylnonanoyl-CoA
is: HMDB11604
constant: false
initial amount: NaN
initial concentration: 1.0

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR r1573
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110005#_f46f689e_8b7a_4fc9_a64a_191e3aacee72
has only substance units: false
initial amount: NaN
is: P30837
is: SBO:0000252
initial concentration: NaN
name: ALDH1B1
boundary condition: true
is encoded by: hsa:219
type: Species
constant: false

metaR r2354
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_6ca8eb54_9179_487c_a507_217bab6a4419
boundary condition: true
has only substance units: false
name: _BC005314_1_x
is encoded by: hsa:BC005314
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_533ca29b_e080_4874_a906_b0a90e1d7a36
boundary condition: true
is encoded by: hsa:48
initial amount: NaN
has only substance units: false
name: ACO1
is: P21399
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

metaM dudp m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
is: HMDB01000
type: Species
has only substance units: false
name: dUDP(3-)
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:60471

http://identifiers.org/biomodels.db/MODEL1310110005#_a2d5a5fb_5250_4d53_8775_0385511721c1
is encoded by: hsa:38
name: ACAT1
constant: false
initial amount: NaN
is: P24752
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR r1928
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110005#
name: Y+LAT2 Utilized transport
product: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
is described by: ECO:0000000
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110005#_19856445_23f4_4294_8f87_f9d03686268e
constant: false
has part: Q9UM01
is encoded by: hsa:9056
type: Species
name: SLC3A1:SLC7A7
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110005#_8c3e1a57_96c5_4fcf_bc62_9f710cb6eca0
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR r0940
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110005#
name: Free diffusion
reversible: true
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110005#
is: SBO:0000185

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR NACDe
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_4041f660_d2b0_4187_b69b_70119f908d5e
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: ENTPD2
has only substance units: false
constant: false
is: Q5SPY7
initial amount: NaN
is encoded by: hsa:954

metaM udpg r
is: SBO:0000247
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00286
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: CHEBI:58367

metaR r2355
type: Reaction
fast: false
is: SBO:0000185
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_b6d23311_18a6_4070_a27b_419d7249e992
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: Q9NY65
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1962
name: EHHADH

metaM dudp n
boundary condition: false
is: CHEBI:60471
initial concentration: 1.0
is: HMDB01000
has only substance units: false
name: dUDP(3-)
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
type: Species

metaR r0618
kinetic law: MODEL1310110005#
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110005#
type: Reaction
fast: false
product: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:

metaR SUCCtp
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
name: succinate transporter, peroxisome
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110005#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_44731410_845e_4738_a865_291202470086
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:1809
name: DPYSL3
type: Species
is: Q8IXW6
is: SBO:0000252
boundary condition: true

metaR ACACt2
reversible: true
reactant: MODEL1310110005#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110005#
is described by: ECO:0000269
name: acetoacetate transport via proton symport
product: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_82a75181_01a7_48e8_89df_42c326b43c16
is: SBO:0000252
type: Species
has only substance units: false
is: P51687
boundary condition: true
is encoded by: hsa:6821
initial amount: NaN
name: SUOX
initial concentration: NaN
constant: false

metaR BALAtmr
name: Beta-alanine reversible mitochondrial transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reactant: MODEL1310110005#
reversible: true
fast: false
product: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110005#
type: Reaction

metaM HC01610 e
initial amount: NaN
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
has only substance units: false
name: CoproporphyrinogenI
is: SBO:0000247
type: Species
boundary condition: false
constant: false
is: CHEBI:28607
initial concentration: 1.0

metaM chol m
constant: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: CHEBI:15354
initial concentration: 1.0
name: choline
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00097
has only substance units: false

metaR RE1530C
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: RE1530
type: Reaction
fast: false
product: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#

metaM arachdcrn m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB01322
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
type: Species
is: CHEBI:57387

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaM xylu L c
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
name: L-xylulose
boundary condition: false
is: SBO:0000247
is: CHEBI:17399
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB00751

http://identifiers.org/biomodels.db/MODEL1310110005#_f3ed7801_5542_44d0_8134_e1161885eb91
type: Species
has only substance units: false
initial concentration: NaN
is: Q16790
is: SBO:0000252
is encoded by: hsa:768
initial amount: NaN
boundary condition: true
constant: false
name: CA9

http://identifiers.org/biomodels.db/MODEL1310110005#_5e37a534_1a3b_43cb_8ffb_f11261b605fc
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51
constant: false
is: SBO:0000252
is: B4DK61
type: Species
name: ACOX1

http://identifiers.org/biomodels.db/MODEL1310110005#_9c1d098f_8eea_4cb1_b1e1_7afb87ccfe55
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q7LG56
has only substance units: false
type: Species
name: RRM2B
is encoded by: hsa:50484
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_49910ed5_4c8b_4f04_b7e2_38cb0d1d7d67
is encoded by: hsa:55753
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: Q9ULD0
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: OGDHL

http://identifiers.org/biomodels.db/MODEL1310110005#_381c3446_78b7_443e_bc4f_848fed2177c4
has only substance units: false
name: _AI378339_1_m
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AI378339
constant: false

metaR r2356
product: MODEL1310110005#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_c1aaa0a1_f77d_4921_af04_6eab1925900b
name: ALDH4A1
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8659

metaR ACt2m
is: SBO:0000185
product: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
name: acetate mitochondrial transport via proton symport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
reactant: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
fast: false

metaM chol n
constant: false
initial concentration: 1.0
has only substance units: false
name: choline
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
type: Species
is: HMDB00097

metaR GLYtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
name: glycine passive transport to mitochondria
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
reversible: true

metaR r0193
fast: false
is described by: ECO:0000000
product: MODEL1310110005#
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaM 10fthf c
is: CHEBI:57454
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: 10-Formyltetrahydrofolate
type: Species
is: HMDB00972
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_0b0e6e38_6365_421a_a310_85ee8839d624
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
name: NDUFA10
is encoded by: hsa:4705
is: O95299
is: SBO:0000252

metaR r0942
type: Reaction
kinetic law: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
reversible: true
fast: false
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
is: SBO:0000185
reactant: MODEL1310110005#
product: MODEL1310110005#

metaR r1019
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
name: Postulated transport reaction
reactant: MODEL1310110005#
fast: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185
type: Reaction

metaR LTC4CP
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
reactant: MODEL1310110005#
fast: false
name: Leukotriene C4 carboxypeptidase
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110005#
is: SBO:0000176

metaM cholate c
is: CHEBI:29747
initial amount: NaN
is: HMDB00619
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
name: Cholate
type: Species

metaR r2357
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_16892beb_cce0_4ced_9b00_c3bd4e8d92c5
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: ADHFE1
is encoded by: hsa:137872
boundary condition: true
constant: false
is: Q8IWW8
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_a6da4778_8a13_42e7_b508_33121c4711a1
name: NDUFA4
boundary condition: true
is encoded by: hsa:4697
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is: O00483

http://identifiers.org/biomodels.db/MODEL1310110005#_8e2d6781_c64f_4b5f_a56a_ec9f7730ae93
type: Species
boundary condition: true
is: O75489
is encoded by: hsa:4722
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
name: NDUFS3

metaM prostgh2 c
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01381
constant: false
is: CHEBI:57405
name: prostaglandin H2(1-)
initial amount: NaN
type: Species
has only substance units: false

metaR GGT6
type: Reaction
name: Gamma-glutamyltransferase
reversible: true
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
reactant: MODEL1310110005#
is described by: ECO:0000000

metaR MTHFD2m
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
type: Reaction
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000254
reversible: true
product: MODEL1310110005#
modifier: MODEL1310110005#

metaM sphmyln hs c
type: Species
boundary condition: false
is: HMDB00156
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: CHARGE: 0
is: CHEBI:15589
constant: false
name: sphmyln_hs[c]

metaM hdca c
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
name: palmitate
constant: false
is: CHEBI:7896
is: HMDB00220
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

metaM o2 x
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
name: O2
initial amount: NaN
is: SBO:0000247
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
is: CHEBI:15379
boundary condition: false

metaR RE0830N
modifier: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
name: RE0830
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
kinetic law: MODEL1310110005#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110005#

metaM HC00250 c
is: CHEBI:29919
initial amount: NaN
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial concentration: 1.0
name: hydrosulfide
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false

metaR r1018
name: Transport reaction
kinetic law: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110005#
is: SBO:0000185

metaR O2t
name: o2 transport (diffusion)
product: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
is: SBO:0000185
fast: false
type: Reaction
reversible: true
is described by: ECO:0000000

metaR r2358
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110005#_056f95b1_0c52_4f7f_b809_62fd2b04632c
initial concentration: NaN
name: PPA2
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: F8WDN9
constant: false
type: Species
is encoded by: hsa:27068

http://identifiers.org/biomodels.db/MODEL1310110005#_c608a359_8c45_49f1_a61f_ef30e894b2f5
name: COX7A2L
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:9167
boundary condition: true
has only substance units: false
is: Q6FGA0
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_f49d1c4f_c73b_4a77_9bbc_b2312838cd70
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is: Q06830
initial amount: NaN
is encoded by: hsa:5052
name: PRDX1
has only substance units: false

metaR RETI1
reactant: MODEL1310110005#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110005#
kinetic law: MODEL1310110005#
name: retinol isomerase (11-cis)
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaM HC01377 m
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119
is: CHEBI:27462
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: S-(3-Methylbutanoyl)-dihydrolipoamide

metaR r0191
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110005#
is: SBO:0000176
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.24
reversible: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaM cholate e
is: CHEBI:29747
is: HMDB00619
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
type: Species
name: Cholate
initial amount: NaN

metaR r0944
fast: false
is described by: ECO:0000000
reactant: MODEL1310110005#
name: Active transport
is: SBO:0000185
kinetic law: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
reversible: true

metaR r0614
kinetic law: MODEL1310110005#
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
fast: false
is described by: ECO:0000000
reactant: MODEL1310110005#
reversible: true
type: Reaction
product: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR RETI2
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.7 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
reversible: true
is described by: ECO:0000000
name: retinol isomerase (9-cis)
fast: false

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_e3d11bad_c2fa_4123_9d27_d0e6c96a93cf
boundary condition: true
initial amount: NaN
type: Species
is: P00915
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:759
name: CA1

metaR r2359
name: Organic anion transporter 5 Utilized transport
fast: false
reactant: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true

metaM HC00250 e
boundary condition: false
type: Species
has only substance units: false
name: hydrosulfide
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
is: CHEBI:29919

metaM accoa c
is: CHEBI:57288
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
is: HMDB01206
is: C00024
name: Acetyl-CoA

metaM zymstnl r
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
is: CHEBI:16608
has only substance units: false
initial concentration: 1.0
name: 5alpha-cholest-8-en-3beta-ol
constant: false
boundary condition: false
is: HMDB06841

metaM hdca e
constant: false
is: C00249
notes: FORMULA: C16H31O2 CHARGE: -1
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00220
type: Species
name: Hexadecanoate (n-C16:0)
has only substance units: false
is: CHEBI:0
initial concentration: 1.0

metaR CRNtx
reactant: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12814641,PMID:15464416 NOTES:mechanism not currently elucidated NJ
is described by: ECO:0000000
product: MODEL1310110005#
is: SBO:0000185
name: carnitine transport peroxisome to mitochondria
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_7ea5ec0e_1536_4f8b_bf66_2555025a373e
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
name: GSR
is encoded by: hsa:2936
boundary condition: true
initial amount: NaN
is: P00390
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_41606343_396f_443d_b9a2_23bfd0250958
name: NDUFS6
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4726
has only substance units: false
constant: false
is: SBO:0000252
is: Q6IBC4
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_8e29aa23_5429_4a3b_b59a_7d41dd8f79bb
initial concentration: NaN
boundary condition: true
name: _AI631997_1_m
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI631997
is: SBO:0000252
type: Species

metaR r0340
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
type: Reaction
modifier: MODEL1310110005#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.3.1.38
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
product: MODEL1310110005#
reversible: false

metaM prostgh2 e
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
name: prostaglandin H2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
initial concentration: 1.0
is: HMDB01381
is: CHEBI:57405
constant: false
is: SBO:0000247

metaR PUNP4
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
kinetic law: MODEL1310110005#
product: MODEL1310110005#
name: purine-nucleoside phosphorylase (Deoxyguanosine)
modifier: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase

http://identifiers.org/biomodels.db/MODEL1310110005#_f8cef925_4b74_480f_a0d5_510d88b7ec34
has only substance units: false
is: P24311
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:1349
boundary condition: true
initial concentration: NaN
constant: false
name: COX7B

metaR CHOLESTle
is version of: http://identifiers.org/ec-code/3.1.1.13
fast: false
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110005#
is: SBO:0000176
modifier: MODEL1310110005#
reactant: MODEL1310110005#
reversible: false
product: MODEL1310110005#
name: hydrolysis of cholesterol ester by cholesterol esterase

metaR r0946
reactant: MODEL1310110005#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
is: SBO:0000185
product: MODEL1310110005#
reversible: true

metaM chsterol e
type: Species
is: CHEBI:16113
is: HMDB00067
has only substance units: false
name: cholesterol
initial amount: NaN
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR TKT2
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
type: Reaction
name: transketolase
product: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/2.2.1.1
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaR RE1520M
fast: false
product: MODEL1310110005#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
is: SBO:0000176
name: RE1520
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM arachd e
initial concentration: 1.0
boundary condition: false
is: CHEBI:32395
is: SBO:0000247
is: HMDB01043
name: arachidonate
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_4df46869_a6fc_4c69_bdc9_5d4ede9b6787
boundary condition: true
is encoded by: hsa:7378
name: UPP1
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: Q16831
initial concentration: NaN
has only substance units: false

metaM prostgf2 e
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB01139
has only substance units: false
initial concentration: 1.0
is: CHEBI:57404
initial amount: NaN
name: prostaglandin F2alpha(1-)
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639

http://identifiers.org/biomodels.db/MODEL1310110005#_87cb0a4c_63ab_4b71_8ad3_e284c704ebc0
initial concentration: NaN
is: SBO:0000252
name: SLC5A2
is encoded by: hsa:6524
type: Species
has only substance units: false
is: P31639
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_18a116d0_4fa4_4535_98a5_cbe0b83136de
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: _AI818585_1_c
is encoded by: hsa:AI818585
boundary condition: true

metaR PUNP3
modifier: MODEL1310110005#
name: purine-nucleoside phosphorylase (Guanosine)
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110005#
product: MODEL1310110005#
fast: false
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_58841b65_0da1_48ce_8692_97029951a3b5
is encoded by: hsa:3158
initial amount: NaN
is: P54868
has only substance units: false
name: HMGCS2
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species

metaR DALAt2r
name: D-alanine transport via proton symport
modifier: MODEL1310110005#
is described by: ECO:0000304
reversible: true
is: SBO:0000185
product: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_fc1380a5_c6ce_4bc7_88bd_8c021708ab8d
has only substance units: false
boundary condition: true
type: Species
name: _AI090874_1_c
is encoded by: hsa:AI090874
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_d55c3b6f_4239_49f1_b53e_1f8d69924f47
type: Species
initial concentration: NaN
initial amount: NaN
name: PANK3
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:79646
is: Q9H999
boundary condition: true

metaM 3oddcoa m
constant: false
is: SBO:0000247
is: CHEBI:27868
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: HMDB03937
name: 3-Oxododecanoyl-CoA
has only substance units: false
boundary condition: false

metaR TKT1
is described by: ECO:0000000
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/2.2.1.1
type: Reaction
name: transketolase
product: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is: SBO:0000176

metaR PROSTGH2t
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: Prostaglandin H2 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reversible: true
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_d67b712e_7a63_4d9e_8d36_05a97ee29472
is encoded by: hsa:570
type: Species
boundary condition: true
constant: false
is: SBO:0000252
name: BAAT
has only substance units: false
is: Q14032
initial amount: NaN
initial concentration: NaN

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_e17c1b06_5e35_4601_ad56_12a3a5c0e126
boundary condition: true
name: SUCLG2:SUCLG1
has part: Q96I99
initial concentration: NaN
is encoded by: hsa:8801
has part: P53597
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:8802
is: SBO:0000297

metaR r0497
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
is: SBO:0000176
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.2
type: Reaction

metaR DNDPt36m
modifier: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000269
kinetic law: MODEL1310110005#
reversible: false
name: dGDP transport via dCDP antiport
reactant: MODEL1310110005#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR r1920
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
reactant: MODEL1310110005#
product: MODEL1310110005#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaR PUNP6
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110005#
name: purine-nucleoside phosphorylase (Deoxyinosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110005#

metaM ahcys m
type: Species
is: CHEBI:16680
constant: false
name: S-Adenosyl-L-homocysteine
boundary condition: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial amount: NaN
is: SBO:0000247
is: HMDB00939
has only substance units: false
initial concentration: 1.0
is: C00021

metaM lac D c
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
constant: false
boundary condition: false
type: Species
name: (R)-lactate
initial amount: NaN
is: SBO:0000247
is: CHEBI:16004
has only substance units: false
is: HMDB01311
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_896da713_59ec_4f74_847c_6322d684b05e
initial concentration: NaN
is encoded by: hsa:1103
boundary condition: true
is: D3DX95
constant: false
initial amount: NaN
has only substance units: false
name: CHAT
type: Species
is: SBO:0000252

metaM 56dthm m
is: HMDB00079
is: SBO:0000247
boundary condition: false
name: 5,6-dihydrothymine
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:27468
type: Species

metaM HC00342 c
type: Species
name: cis-aconitate(3-)
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:16383
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
constant: false

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR H2O2tn
is described by: ECO:0000000
name: hydrogen peroxide nuclear transport
type: Reaction
fast: false
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
reversible: true
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it

metaM chsterol c
is: SBO:0000247
has only substance units: false
name: cholesterol
type: Species
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
is: HMDB00067
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0

metaR PRODt2r
name: D-proline reversible transport via proton symport
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is: SBO:0000185
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
type: Reaction
is described by: ECO:0000304
reversible: true
product: MODEL1310110005#
fast: false

metaR MCLACCYSR
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
name: 3-mercaptolactate:cysteine reductase
product: MODEL1310110005#
type: Reaction
fast: false
kinetic law: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110005#_3ea54c6c_fe89_41ab_ade3_fba1e92c90c7
is encoded by: hsa:7296
has only substance units: false
constant: false
name: TXNRD1
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaR PGLYCt
reactant: MODEL1310110005#
name: phosphatidylglycerol transport
kinetic law: MODEL1310110005#
type: Reaction
is described by: ECO:0000269
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
product: MODEL1310110005#

metaR 5ADTSTSTERONESte
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
is described by: ECO:0000000
type: Reaction
name: sulfonated testosterone transport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110005#

metaR RE3272N
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
is: SBO:0000176
reversible: true
product: MODEL1310110005#
name: RE3272
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
fast: false
type: Reaction

metaR ABUTD
reversible: false
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
is: SBO:0000176
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000269
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
name: Aminobutyraldehyde dehydrogenase
type: Reaction
kinetic law: MODEL1310110005#

metaR PUNP5
reversible: true
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110005#
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Inosine)
modifier: MODEL1310110005#

metaR ALAGLYexR
is described by: ECO:0000304
modifier: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
name: L-alanine/glycine reversible exchange

http://identifiers.org/biomodels.db/MODEL1310110005#_ea64fb82_8135_413f_adea_afa2dee62611
boundary condition: true
is encoded by: hsa:6582
has only substance units: false
constant: false
initial amount: NaN
name: SLC22A2
type: Species
is: O15244
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_11a568ee_b62d_440b_817c_11ea72de1750
is: SBO:0000252
is: O43674
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4711
name: NDUFB5
initial amount: NaN
has only substance units: false
type: Species

metaM CE2420 m
is: CHEBI:28387
has only substance units: false
boundary condition: false
type: Species
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
is: SBO:0000247
constant: false
is: HMDB11123
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420

metaR CLFORtex
fast: false
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reversible: false
type: Reaction
reactant: MODEL1310110005#
name: chloride transport via formate countertransport
product: MODEL1310110005#
modifier: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
is described by: ECO:0000304

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaR RE1897C
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
kinetic law: MODEL1310110005#
product: MODEL1310110005#
name: RE1897
fast: false
is: SBO:0000176
reactant: MODEL1310110005#
is described by: ECO:0000000
reversible: true
type: Reaction

metaR r1864
name: Y+LAT2 Utilized transport
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_1d02c99f_8c97_4b16_bf6c_4e155f20e193
has only substance units: false
boundary condition: true
is encoded by: hsa:84569
is: Q6UWQ5
type: Species
constant: false
name: LYZL1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR PIt7
product: MODEL1310110005#
is described by: ECO:0000269
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110005#
fast: false
name: phosphate transport in/out via three Na+ symporter
reactant: MODEL1310110005#
type: Reaction
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT

http://identifiers.org/biomodels.db/MODEL1310110005#_bb567f67_8710_4798_ae6a_6061f9951c88
is encoded by: hsa:29968
initial amount: NaN
has only substance units: false
is: Q9Y617
name: PSAT1
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
type: Species

metaR GLYCK2
name: glycerate kinase
reversible: false
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.31 Confidence Level: 2 AUTHORS: PMID:9038835 NOTES:JLR
fast: false

metaR LEUTAm
reactant: MODEL1310110005#
type: Reaction
reversible: true
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000269
fast: false
name: leucine transaminase, mitochondrial
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD

metaM 2mp2coa m
is: HMDB01011
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:27754
name: 2-Methylprop-2-enoyl-CoA
type: Species
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_d6980227_82e3_44ee_9b58_0b6618c8e916
initial concentration: NaN
has only substance units: false
constant: false
name: GLRX2
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:51022
is: SBO:0000252
is: Q9NS18

metaR RE0830C
is described by: ECO:0000000
product: MODEL1310110005#
is: SBO:0000176
name: RE0830
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
fast: false
type: Reaction

metaR r1722
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110005#
fast: false
is: SBO:0000185
reactant: MODEL1310110005#
reversible: false
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000

metaR r0345
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110005#
is described by: ECO:0000000
reversible: true
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.13

metaR PUNP7
reversible: true
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110005#
name: purine-nucleoside phosphorylase (Xanthosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn

metaM fru e
is: HMDB00660
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: D-Fructose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: C00095
is: SBO:0000247
is: CHEBI:15824
type: Species

metaR H2O2tp
name: hydrogen peroxide peroxisomal transport via diffusion
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_cd710f0a_1967_4336_b4e9_a13da65b9c1d
is: SBO:0000252
name: ESPN
boundary condition: true
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:83715
is: B1AK53
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_557ca0ca_2d77_4868_86c4_c9943c01023f
is encoded by: hsa:7108
initial concentration: NaN
has only substance units: false
is: O76062
name: TM7SF2
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_a79ca6ac_9d85_4525_941d_ffa77d0d126b
is encoded by: hsa:4698
boundary condition: true
is: Q16718
constant: false
name: NDUFA5
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_6e1025d7_e67e_48f4_a135_3e46a40ee549
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: NOS3
is encoded by: hsa:4846
constant: false
initial concentration: NaN
has only substance units: false
is: A0S0A7

metaR BTNTe
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of biotin across the basolatral membrane
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_4b049a09_d574_4690_adb6_08385fb16ad0
constant: false
is: SBO:0000252
is encoded by: hsa:H77542
type: Species
has only substance units: false
name: _H77542_1_c
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_12cc7aa9_c55e_4a9b_88f1_b561bd50a9c1
boundary condition: true
name: MCCC1
is encoded by: hsa:56922
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q96RQ3

metaR NDPK8n
is described by: ECO:0000304
modifier: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
product: MODEL1310110005#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110005#
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear

metaM rib D e
initial amount: NaN
is: CHEBI:16988
constant: false
is: SBO:0000247
has only substance units: false
name: D-ribose
boundary condition: false
type: Species
is: HMDB00283
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial concentration: 1.0

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaM fru c
type: Species
is: SBO:0000247
boundary condition: false
name: D-Fructose
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: HMDB00660
has only substance units: false
is: C00095
is: CHEBI:15824

metaM dump c
boundary condition: false
type: Species
constant: false
is: HMDB01409
is: C00365
is: CHEBI:246422
initial amount: NaN
name: dUMP
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_0ad57ece_aa60_43a5_a398_2a8f8c6f35c6
initial amount: NaN
is encoded by: hsa:50484
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
name: RRM2B
type: Species
boundary condition: true
is: Q7LG56

metaM xu5p D c
boundary condition: false
initial amount: NaN
is: CHEBI:57737
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
is: HMDB00868
name: D-xylulose 5-phosphate(2-)
has only substance units: false
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_9ac208d1_4f37_4698_afa1_289bcb7f8d52
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:226
constant: false
type: Species
name: ALDOA
initial concentration: NaN

metaR r1862
reactant: MODEL1310110005#
is described by: ECO:0000000
modifier: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110005#
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_03f46faa_cb9f_4916_8ffc_58019720c633
boundary condition: true
constant: false
is: P00325
is encoded by: hsa:125
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: ADH1B
initial amount: NaN
type: Species

metaM sql r
constant: false
has only substance units: false
type: Species
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
is: SBO:0000247
initial amount: NaN
is: HMDB00256
is: CHEBI:15440
boundary condition: false
initial concentration: 1.0
name: squalene

metaR CYOOm3
name: cytochrome c oxidase, mitochondrial Complex IV
is described by: ECO:0000134
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
is version of: http://identifiers.org/ec-code/1.9.3.1
reactant: MODEL1310110005#
fast: false
reversible: false
product: MODEL1310110005#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_c481ebb2_6602_4f81_941d_efd8989aa958
constant: false
initial concentration: NaN
boundary condition: true
name: SDHA
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P31040
type: Species
is encoded by: hsa:6389

metaM pail hs n
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol(1-)
constant: false
is: CHEBI:57880
type: Species
initial amount: NaN

metaM man e
is: SBO:0000247
is: HMDB00169
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00159
name: D-Mannose
is: CHEBI:16024
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_0014f654_0c05_47e4_8cee_0f03d9cab388
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:51727
has only substance units: false
name: CMPK1
is: B2R6S5

metaR ALAGLNexR
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000304
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
is: SBO:0000185
name: L-alanine/glutamine reversible exchange
kinetic law: MODEL1310110005#
reversible: true

metaR PIt8
name: phosphate transport in/out via Na+ symporter
modifier: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
reactant: MODEL1310110005#
type: Reaction
is described by: ECO:0000006
is: SBO:0000185
fast: false
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_99cb12c6_8af6_4358_90ac_55a306740bf1
boundary condition: true
is: P19801
has only substance units: false
initial concentration: NaN
name: ABP1
type: Species
is encoded by: hsa:26
initial amount: NaN
constant: false
is: SBO:0000252

metaM arachd c
constant: false
is: SBO:0000247
is: CHEBI:32395
is: HMDB01043
name: arachidonate
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species

metaM Sfglutth c
initial amount: NaN
type: Species
name: S-formylglutathionate(1-)
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
boundary condition: false
is: HMDB01550
constant: false
is: CHEBI:57688
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_d2daeabc_2e2b_467d_b68b_72e93fd95e62
constant: false
is encoded by: hsa:230
type: Species
has only substance units: false
initial amount: NaN
is: P09972
is: SBO:0000252
name: ALDOC
boundary condition: true
initial concentration: NaN

metaR MTHGXLt
reactant: MODEL1310110005#
is described by: ECO:0000000
name: Methylglyoxal transport (cytosol to extracellular)
product: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
is: SBO:0000185
fast: false
reversible: false
type: Reaction

metaM gthrd e
is: CHEBI:57925
is: HMDB00125
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false
initial amount: NaN
has only substance units: false
name: glutathionate(1-)
type: Species

metaM nad c
is: C00003
is: http://identifiers.org/pubchem.compound/3305
is: SBO:0000247
initial amount: NaN
name: Nicotinamide adenine dinucleotide
constant: false
is: HMDB00902
type: Species
is: CHEBI:57540
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR RE1448N
is: SBO:0000176
name: RE1448
product: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_6ab60df0_9729_491f_9612_a5dfd14f055c
has only substance units: false
is: SBO:0000252
name: ACADS
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: P16219
type: Species
is encoded by: hsa:35

metaR NDPK1
is described by: ECO:0000134
fast: false
is: SBO:0000176
reversible: true
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110005#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:GDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_6c0baf4d_c72b_43ec_8075_e427fceea7fe
constant: false
name: _D87002_1_e
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:D87002
has only substance units: false
is: SBO:0000252

metaR r1459
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110005#
name: Transport reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_3e140b95_6aeb_4a1d_b7f0_0480eaa3f281
initial concentration: NaN
name: ALDH3A1
has only substance units: false
type: Species
is: SBO:0000252
is: P30838
boundary condition: true
constant: false
is encoded by: hsa:218
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_07057167_b879_4593_a9ba_881d0d870ce1
name: _R06874_1_r
is encoded by: hsa:R06874
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252

metaR r1669
is described by: ECO:0000000
kinetic law: MODEL1310110005#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110005#
type: Reaction
reversible: true
product: MODEL1310110005#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110005#

metaR RE2799C
is: SBO:0000176
reversible: true
product: MODEL1310110005#
type: Reaction
name: RE2799
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_80dcae72_01c4_40d3_9ec7_354a4c723cc6
has only substance units: false
is: P00441
boundary condition: true
name: SOD1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:6647
type: Species

metaM nadph c
is: CHEBI:57783
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: false
is: C00005
is: HMDB00221

metaR NDPK2
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
name: nucleoside-diphosphate kinase (ATP:UDP)
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110005#
is: SBO:0000176
reversible: true

metaR r0434
is: SBO:0000176
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#

metaR PTPATe
is described by: ECO:0000134
fast: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110005#
type: Reaction
reversible: true
product: MODEL1310110005#
is: SBO:0000176
name: PTPATe

http://identifiers.org/biomodels.db/MODEL1310110005#_bf46f600_a958_47ea_a631_6226ce420c57
is: Q01959
initial amount: NaN
is encoded by: hsa:6531
initial concentration: NaN
is: SBO:0000252
constant: false
name: SLC6A3
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_8a18afa1_65f3_41b4_89ba_255e3885b18c
name: PI4KB
is: Q9UBF8
is: SBO:0000252
constant: false
is encoded by: hsa:5298
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_3c5039a0_4ee4_4753_9f6b_7797364e0bdf
initial amount: NaN
name: AKR1A1
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:10327

metaM gthrd c
initial amount: NaN
is: CHEBI:57925
has only substance units: false
initial concentration: 1.0
is: HMDB00125
is: SBO:0000247
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
constant: false
type: Species
boundary condition: false
name: Reduced glutathione
is: C00051

metaR URIt
fast: false
kinetic law: MODEL1310110005#
is: SBO:0000185
name: uridine facilated transport in cytosol
reactant: MODEL1310110005#
type: Reaction
reversible: true
is described by: ECO:0000269
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
modifier: MODEL1310110005#

metaM malcoa c
initial concentration: 1.0
name: Malonyl-CoA
is: SBO:0000247
constant: false
initial amount: NaN
is: C00083
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
boundary condition: false
is: HMDB01175
is: CHEBI:57384
type: Species
has only substance units: false

metaM cala c
type: Species
is: HMDB00026
is: SBO:0000247
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
name: N-carbamoyl-beta-alaninate
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:11892

metaR r2511
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110005#
name: Utilized transport
is described by: ECO:0000000

metaR FUMTSULtm
reversible: true
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
kinetic law: MODEL1310110005#
type: Reaction
modifier: MODEL1310110005#
name: Fumarate:thiosulfate antiport, mitochondrial

metaM hmgcoa m
initial amount: NaN
type: Species
is: HMDB01375
name: Hydroxymethylglutaryl-CoA
has only substance units: false
initial concentration: 1.0
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_a6ae0d1c_d35e_4264_8cda_5a19c8dc8ee2
type: Species
initial concentration: NaN
name: OGDH
initial amount: NaN
is encoded by: hsa:4967
has only substance units: false
is: Q02218
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_74b3d929_304f_47df_841e_eb84d0e7f2d1
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:55907
is: Q8NFW8
name: CMAS
constant: false
initial concentration: NaN
is: SBO:0000252

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR NDPK3
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110005#
name: nucleoside-diphosphate kinase (ATP:CDP)
product: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
type: Reaction
reversible: true
modifier: MODEL1310110005#
is: SBO:0000176

metaM prostge2 e
initial concentration: 1.0
is: HMDB01220
boundary condition: false
type: Species
name: prostaglandin E2(1-)
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:606564
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584

metaR r1668
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110005#
reversible: true
is: SBO:0000185
modifier: MODEL1310110005#
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110005#
type: Reaction
product: MODEL1310110005#

metaR GLYt2r
kinetic law: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
fast: false
modifier: MODEL1310110005#
reversible: true
is described by: ECO:0000304
name: glycine reversible transport via proton symport

http://identifiers.org/biomodels.db/MODEL1310110005#_e529df72_45ed_49d2_b0c6_e71bc374ea11
has only substance units: false
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5162
name: PDHB
boundary condition: true
is: P11177
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_815bae06_68ad_4f7d_881f_633a418226d6
is: E9KL44
is encoded by: hsa:3030
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: HADHA
initial amount: NaN
type: Species
has only substance units: false

metaM kynate c
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
name: kynurenate
is: CHEBI:58454
initial amount: NaN
is: HMDB00715
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
type: Species

metaR r0541
kinetic law: MODEL1310110005#
reversible: true
modifier: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
type: Reaction
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
is: SBO:0000176

metaR IDPtn
fast: false
name: IDP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110005#
product: MODEL1310110005#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000185

metaR RE0453C
reversible: true
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
type: Reaction
name: RE0453
is: SBO:0000176
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_a05bf297_9d66_49db_95ad_687f7b118779
has only substance units: false
boundary condition: true
constant: false
type: Species
is: Q9Y259
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1120
initial amount: NaN
name: CHKB

metaM prostge1 e
initial amount: NaN
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
boundary condition: false
is: CHEBI:57397
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01442
name: prostaglandin E1(1-)

metaR NDPK4
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000269
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
reversible: true
name: nucleoside-diphosphate kinase (ATP:dTDP)
is: SBO:0000176
fast: false

metaR GCC2bim
is: SBO:0000176
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/2.1.2.10
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4

metaR r1667
is: SBO:0000185
type: Reaction
product: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_ff2334a1_2f7c_4b06_8890_80bf7c4b6e2e
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P48448
name: ALDH3B2
constant: false
is encoded by: hsa:222
is: SBO:0000252

metaR PI4PP
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000000
name: phosphatidylinositol-4-phosphate 4-phosphatase
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
reactant: MODEL1310110005#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110005#

metaR NADPHtru
is described by: ECO:0000000
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110005#
fast: false
name: NADPH transporter, endoplasmic reticulum
is: SBO:0000185
reactant: MODEL1310110005#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110005#_04752327_a55e_4539_9508_fb7c848013c9
is encoded by: hsa:4512
has part: P13073
is encoded by: hsa:84701
is encoded by: hsa:1346
has part: Q02221
has only substance units: false
has part: Q53XN1
is encoded by: hsa:1329
is encoded by: hsa:170712
initial amount: NaN
has part: P24311
has part: Q6YFQ2
has part: P24310
has part: P12074
is encoded by: hsa:9377
has part: Q7Z4L0
is encoded by: hsa:1340
is encoded by: hsa:1345
has part: Q7GXZ8
has part: Q8TF08
has part: H0UI06
has part: Q6FGA0
is encoded by: hsa:4514
is encoded by: hsa:1347
is encoded by: hsa:125965
is encoded by: hsa:341947
type: Species
has part: P09669
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:1351
has part: P14854
has part: Q96KJ9
is encoded by: hsa:1339
is: SBO:0000297
boundary condition: true
is encoded by: hsa:1327
initial concentration: NaN
has part: P20674
is encoded by: hsa:4513
is encoded by: hsa:1349
has part: Q7GXY8
has part: P00414
is encoded by: hsa:1350
has part: Q53YB7
constant: false
has part: P15954
is encoded by: hsa:9167
is encoded by: hsa:1337

metaM aacoa m
is: HMDB01484
is: SBO:0000247
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
type: Species
is: CHEBI:57286
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
name: acetoacetyl-CoA(4-)
has only substance units: false

metaR 3MOX4HOXPGALDOX NADP
is: SBO:0000176
kinetic law: MODEL1310110005#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
fast: false
is described by: ECO:0000304
product: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true

metaR r0437
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
product: MODEL1310110005#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
kinetic law: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: MODEL1310110005#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110005#

metaR EX crm hs LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acylsphingosine exchange
type: Reaction

metaR r1455
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
name: Transport reaction
product: MODEL1310110005#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reversible: false
is: SBO:0000185

metaM ptth m
name: pantetheine
type: Species
constant: false
boundary condition: false
is: HMDB03426
initial concentration: 1.0
is: CHEBI:16753
initial amount: NaN
has only substance units: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: SBO:0000247

metaR NDPK5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000269
name: Nucleoside-diphosphate kinase (ATP:dGDP)
reversible: true
modifier: MODEL1310110005#

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR r0650
modifier: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
fast: false
kinetic law: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
product: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.36
reactant: MODEL1310110005#

metaR RE0915E
reactant: MODEL1310110005#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000
kinetic law: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
name: RE0915
is: SBO:0000176
modifier: MODEL1310110005#
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.2.1.1

metaM prostge2 c
constant: false
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: CHEBI:606564
boundary condition: false
is: HMDB01220
name: prostaglandin E2(1-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_c1c8646c_3985_4b5f_b669_7bb6c586a94c
is: SBO:0000252
is encoded by: hsa:2348
constant: false
boundary condition: true
initial concentration: NaN
name: FOLR1
has only substance units: false
initial amount: NaN
type: Species
is: P15328

http://identifiers.org/biomodels.db/MODEL1310110005#_1a3c192f_4579_4a48_afbd_ab9d5bd91867
name: PTS
has only substance units: false
is: SBO:0000252
is: Q03393
constant: false
type: Species
is encoded by: hsa:5805
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_efdf2871_f119_413f_b402_0a296318e62a
initial amount: NaN
name: _728637_1_c
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:728637
has only substance units: false
boundary condition: true

metaR PRO1x
name: L-ProlineNAD+ 5-oxidoreductase
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Transport, extracellular EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
fast: false
is described by: ECO:0000134
modifier: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.99.8
product: MODEL1310110005#
is: SBO:0000176
reversible: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM ahcys e
name: S-Adenosyl-L-homocysteine
type: Species
has only substance units: false
is: C00021
is: CHEBI:16680
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB00939
constant: false
notes: FORMULA: C14H20N6O5S CHARGE: 0

metaR RE3006M
modifier: MODEL1310110005#
name: RE3006
reversible: true
fast: false
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM prpp e
is: HMDB00280
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:58017
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
constant: false
is: SBO:0000247
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
type: Species
initial amount: NaN

metaR r1456
reactant: MODEL1310110005#
reversible: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
name: Transport reaction
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_32932105_a629_4ddb_a15b_e51482791ebc
is encoded by: hsa:126328
is: C9JT23
name: NDUFA11
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaR NDPK6
is described by: ECO:0000269
modifier: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110005#
reversible: true
is: SBO:0000176
fast: false
name: Nucleoside-diphosphate kinase (ATP:dUDP)

http://identifiers.org/biomodels.db/MODEL1310110005#_ac1cf070_0d44_4fa9_97e8_b986b069bdbb
is: SBO:0000252
type: Species
is encoded by: hsa:6342
name: SCP2
is: C9JC79
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaR ADK3
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
reversible: true
reactant: MODEL1310110005#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110005#
type: Reaction
is: SBO:0000176
name: adentylate kinase (GTP)
modifier: MODEL1310110005#

metaM ser D e
has only substance units: false
constant: false
boundary condition: false
is: HMDB03406
is: CHEBI:16523
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
initial concentration: 1.0
initial amount: NaN
name: D-serine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_fb90343b_5725_4ff3_a17a_cf23a16bef9a
constant: false
is: SBO:0000252
boundary condition: true
name: GAPDH
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2597
is: E7EUT4
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_6b736a94_fe7a_43d5_95b2_8e61086eaf97
type: Species
is: SBO:0000252
has only substance units: false
constant: false
name: GPT
is encoded by: hsa:2875
is: P24298
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaM so4 e
type: Species
is: CHEBI:16189
constant: false
is: HMDB01448
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: SBO:0000247
name: sulfate
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_1f07c7c6_68fb_4409_a535_08a50febe772
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5232
constant: false
is: P07205
has only substance units: false
type: Species
name: PGK2

metaR r2443
is described by: ECO:0000000
reversible: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

metaR PROSTGE2t
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
name: prostaglandin transport via bicarbonate countertransport
fast: false
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
is described by: ECO:0000269
product: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_4e5fe802_0ff9_4d3a_b0b2_5279a9aa827e
is: P43004
constant: false
initial amount: NaN
is encoded by: hsa:6506
is: SBO:0000252
has only substance units: false
type: Species
name: SLC1A2
boundary condition: true
initial concentration: NaN

metaR BETALDHxm
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
reversible: false
reactant: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
fast: false
is described by: ECO:0000000
is: SBO:0000176
name: betaine-aldehyde dehydrogenase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110005#_d68b67f3_6d42_4853_8034_78c521c3082e
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: SPHK2
type: Species
is encoded by: hsa:56848
initial concentration: NaN
is: Q9NRA0

metaM C05965 e
has only substance units: false
boundary condition: false
is: HMDB04243
constant: false
name: 12(S)-HPETE(1-)
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
type: Species
is: SBO:0000247
is: CHEBI:57444

http://identifiers.org/biomodels.db/MODEL1310110005#_d4328d41_c195_4ec4_8375_3907fe863f31
is: SBO:0000252
name: STARD3
is: B4DUY1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10948
type: Species
has only substance units: false
constant: false
initial amount: NaN

metaR ACALDt
product: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
name: acetaldehyde reversible transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110005#
reversible: true

metaM nadh c
constant: false
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
initial amount: NaN
initial concentration: 1.0
is: HMDB01487
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3306
is: C00004
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_7bb18d55_c463_44d1_b050_dea4221611c0
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: Q8TE54
is encoded by: hsa:115111
name: SLC26A7
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR NADS2
kinetic law: MODEL1310110005#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
fast: false
name: NAD synthase (glutamine-hydrolysing)
reversible: false
product: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/6.3.5.1
is: SBO:0000176
modifier: MODEL1310110005#

metaR r1453
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
type: Reaction
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
is described by: ECO:0000000
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110005#

metaR NDPK7
name: nucleoside-diphosphate kinase (ATP:dCDP)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110005#
product: MODEL1310110005#
reversible: true
type: Reaction
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176
fast: false

metaM 56dthm c
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: 5,6-dihydrothymine
type: Species
is: HMDB00079
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
boundary condition: false
is: CHEBI:27468

metaM gtp n
is: SBO:0000247
type: Species
is: CHEBI:37565
boundary condition: false
has only substance units: false
constant: false
name: GTP(4-)
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_d2d72652_7941_45c9_bc4c_5c7c6434d82f
name: SCD5
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is: Q86SK9
initial amount: NaN
is encoded by: hsa:79966

http://identifiers.org/biomodels.db/MODEL1310110005#_9d3fa47b_a2cd_40be_aeb5_9ff993f2579a
is: SBO:0000252
is encoded by: hsa:10873
name: ME3
constant: false
has only substance units: false
initial concentration: NaN
is: Q6TCH8
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_15e50f1e_8db5_4ad8_b58f_2e640bc52a0a
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: _D87002_1_m
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:D87002

metaR SUCOASm
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.4
kinetic law: MODEL1310110005#
name: Succinate--CoA ligase (ADP-forming)
product: MODEL1310110005#
is: SBO:0000176
modifier: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.5
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD

http://identifiers.org/biomodels.db/MODEL1310110005#_f58aabd7_ff01_46ec_a671_36cf844c60fc
constant: false
is: P30838
is: SBO:0000252
is encoded by: hsa:218
boundary condition: true
initial concentration: NaN
name: ALDH3A1
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_50570460_466c_47f7_85cb_8f911fa8176d
is: SBO:0000252
constant: false
name: CHAT
is: P28329
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1103

http://identifiers.org/biomodels.db/MODEL1310110005#_3c5e9b5b_7986_49a9_b419_516a0235cca5
boundary condition: true
is encoded by: hsa:54981
is: Q9NWW6
is: SBO:0000252
has only substance units: false
name: NMRK1
initial amount: NaN
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_3f2463c5_f1f0_4d64_a9d6_da17efc95c5c
boundary condition: true
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: AOC2
initial amount: NaN
initial concentration: NaN
is: O75106
is encoded by: hsa:314

metaM pmtcoa m
is: SBO:0000247
type: Species
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: CHEBI:57379
initial concentration: 1.0
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false
constant: false
is: C00154
is: HMDB01338
initial amount: NaN

metaR ADSS
name: adenylosuccinate synthase
product: MODEL1310110005#
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110005#
type: Reaction
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/6.3.4.4
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_43e00ab2_dfeb_4cf6_9cce_11575281bd01
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ECHS1
is encoded by: hsa:1892
constant: false
is: P30084

http://identifiers.org/biomodels.db/MODEL1310110005#_7476d96e_1771_4953_a204_4d8ce96102e3
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:AA526438
name: _AA526438_1_c
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_5610cf4b_2275_4537_a76f_16bef17e1c08
initial amount: NaN
is: Q7Z5T0
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6507
has only substance units: false
name: SLC1A3

metaM thbpt c
has only substance units: false
constant: false
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
is: HMDB00027
type: Species
is: CHEBI:15372
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: 5,6,7,8-tetrahydrobiopterin
initial concentration: 1.0

metaR NDPK8
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
reversible: true
type: Reaction
name: Nucleoside-diphosphate kinase (ATP:dADP)
is described by: ECO:0000269
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110005#

metaR r1454
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reversible: false
is: SBO:0000185
product: MODEL1310110005#
type: Reaction
is described by: ECO:0000000

metaM so4 c
boundary condition: false
type: Species
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
is: HMDB01448
name: sulfate
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM gtp m
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: C00044
name: GTP
is: CHEBI:37565
is: HMDB01273
boundary condition: false
initial amount: NaN

metaM ser D c
is: HMDB03406
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: SBO:0000247
has only substance units: false
type: Species
name: D-serine
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:16523

http://identifiers.org/biomodels.db/MODEL1310110005#_a045a595_7102_4e74_92d2_ccca837f84a2
initial amount: NaN
type: Species
name: PRDX1
boundary condition: true
is encoded by: hsa:5052
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR ADK1
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
product: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
is described by: ECO:0000269
modifier: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: adenylate kinase
is: SBO:0000176
kinetic law: MODEL1310110005#

metaR GLUPROASCT1
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
kinetic law: MODEL1310110005#
name: glutamate intake by system ASCT-1 transporter
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000134
fast: false
reversible: false
is: SBO:0000185
reactant: MODEL1310110005#
modifier: MODEL1310110005#

metaR DHAPtc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000134
name: transport of DHAP into cytosol
fast: false
type: Reaction
reactant: MODEL1310110005#
product: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_02e2f9f0_5680_473d_b8a8_83305bb250fd
has only substance units: false
boundary condition: true
is encoded by: hsa:2639
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
name: GCDH
is: SBO:0000252
is: Q92947

metaM dgmp c
name: dGMP
is: C00362
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: HMDB01044
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:57673
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM nicrns c
type: Species
is: HMDB06809
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
name: Nicotinate D-ribonucleoside
is: CHEBI:58527
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0

metaM crn c
is: HMDB00062
initial amount: NaN
is: CHEBI:16347
is: C00318
boundary condition: false
has only substance units: false
type: Species
constant: false
name: L-Carnitine
initial concentration: 1.0
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247

metaR RE0453N
fast: false
name: RE0453
reversible: true
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaR r1564
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM arachcoa m
type: Species
has only substance units: false
is: CHEBI:15527
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
name: arachidyl coenzyme A
is: HMDB04258
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaR CHSTEROLt1
product: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
is: SBO:0000185
type: Reaction
name: cholesterol intracellular transport
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#

metaR r1662
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM Lcystin e
initial amount: NaN
is: CHEBI:16283
has only substance units: false
name: L-cystine
boundary condition: false
initial concentration: 1.0
is: HMDB00192
is: SBO:0000247
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_3bab9ff3_e73e_444b_9bdd_e1f437ddeae5
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5315
initial amount: NaN
name: PKM2
is: SBO:0000252
type: Species
constant: false

metaM dgdp n
is: HMDB00960
name: dGDP(2-)
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:58595
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
boundary condition: false
type: Species

metaM mescoa m
is: C06028
boundary condition: false
constant: false
name: Mesaconyl-CoA
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27969
is: SBO:0000247
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
has only substance units: false
type: Species

metaM nadph m
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57783
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: C00005
boundary condition: false
initial concentration: 1.0
is: HMDB00221
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial amount: NaN

metaM HC02205 c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial concentration: 1.0
boundary condition: false
name: prostaglandin-b2
initial amount: NaN
type: Species
constant: false
is: CHEBI:28099

http://identifiers.org/biomodels.db/MODEL1310110005#_667c6903_076e_4d00_8ebf_65427d25cd7a
boundary condition: true
initial amount: NaN
name: _AD000092_1_c
has only substance units: false
is encoded by: hsa:AD000092
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

metaM gthrd m
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
name: glutathionate(1-)
is: HMDB00125
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
constant: false
is: SBO:0000247
is: CHEBI:57925
initial concentration: 1.0

metaM pan4p c
constant: false
initial concentration: 1.0
name: Pantetheine 4'-phosphate
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: HMDB01416
is: C01134
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:47942
initial amount: NaN
has only substance units: false

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_a69f9503_4b12_4268_9416_beab4c3f4ce2
constant: false
name: FOLR1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:2348

metaR MMSAD3m
fast: false
reversible: false
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
product: MODEL1310110005#
modifier: MODEL1310110005#
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.2.1.27
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
is described by: ECO:0000269
type: Reaction
is: SBO:0000176

metaR r0653
is: SBO:0000176
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#

metaR RE0453M
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110005#
name: RE0453
reversible: true
product: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110005#

metaR r1565
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR CHSTEROLt2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110005#
name: cholesterol intracellular transport
product: MODEL1310110005#
type: Reaction
fast: false
reactant: MODEL1310110005#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaM pmtcoa c
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:3454
is: HMDB01338
boundary condition: false
constant: false
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)

metaR r1661
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110005#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false

metaR EX glyc S LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (S)-Glycerate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_bb5feef3_a91b_413b_adcf_6b6b3cf92bbe
is: O75874
name: IDH1
is encoded by: hsa:3417
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

metaR PRISTCOAtx
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110005#
name: pristcoa peroxisomal transport
reactant: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
fast: false
is described by: ECO:0000000
type: Reaction

metaM 5fthf m
is: CHEBI:57457
boundary condition: false
name: 5-formyltetrahydrofolate(2-)
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
is: HMDB01562

metaR CYTK6n
name: cytidylate kinase (CMP,CTP),nuclear
is: SBO:0000176
fast: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
modifier: MODEL1310110005#
reversible: true
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaM lnlccrn c
name: Linoleyl carnitine
is: SBO:0000247
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB06469
constant: false

metaM CE2434 m
is: SBO:0000247
is: CHEBI:57795
initial amount: NaN
initial concentration: 1.0
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
constant: false
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434

metaR C14STRr
fast: false
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.3.1.70
name: C-14 sterol reductase
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
reactant: MODEL1310110005#
product: MODEL1310110005#
reversible: false
is: SBO:0000176

metaR FACOAL2042
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
type: Reaction
name: fatty-acid--CoA ligase
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
fast: false
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
modifier: MODEL1310110005#

metaM dgdp m
constant: false
type: Species
name: dGDP(2-)
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58595
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
has only substance units: false
boundary condition: false
is: HMDB00960

metaM dd2coa m
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: CHEBI:57330
name: trans-dodec-2-enoyl-CoA(4-)
type: Species
boundary condition: false
constant: false
is: HMDB03712
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR r0547
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.1.4
product: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true
is described by: ECO:0000000
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
is: SBO:0000176

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

metaR r2519
name: Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
reactant: MODEL1310110005#
fast: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: true
type: Reaction
is described by: ECO:0000000

metaR r1660
type: Reaction
product: MODEL1310110005#
modifier: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reactant: MODEL1310110005#
reversible: true

metaM HC02020 r
initial concentration: 1.0
name: Cholesterol-ester-palm
has only substance units: false
boundary condition: false
is: CHEBI:3663
constant: false
initial amount: NaN
notes: FORMULA: C43H76O2 CHARGE: 0 INCHI: InChI=1S/C43H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-23-41(44)45-36-28-30-42(5)35(32-36)24-25-37-39-27-26-38(34(4)22-20-21-33(2)3)43(39,6)31-29-40(37)42/h24,33-34,36-40H,7-23,25-32H2,1-6H3/t34-,36+,37+,38-,39+,40+,42+,43-/m1/s1
is: SBO:0000247
type: Species

metaR r0652
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
product: MODEL1310110005#
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
is: SBO:0000176

metaM nad m
name: Nicotinamide adenine dinucleotide
has only substance units: false
is: HMDB00902
is: http://identifiers.org/pubchem.compound/3305
constant: false
is: CHEBI:57540
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: C00003
initial amount: NaN

metaR CHSTEROLt3
is: SBO:0000185
product: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110005#
reversible: true
name: cholesterol intracellular transport
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110005#

metaR r1562
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM crn e
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
boundary condition: false
has only substance units: false
type: Species
constant: false
name: L-Carnitine
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00062

metaR GLNtm
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
kinetic law: MODEL1310110005#
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110005#
is: SBO:0000185
fast: false
name: L-glutamine transport via electroneutral transporter

metaM b2coa m
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
is: HMDB02009
is: CHEBI:57332
type: Species
initial concentration: 1.0
name: crotonoyl-CoA(4-)
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_aeb2d603_a11e_43e0_a473_b354d7916b91
initial concentration: NaN
name: ALDH7A1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:501
is: E7EPT3
boundary condition: true
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_3e782b12_5e3a_4e59_818c_ce01b8fa5b7d
has part: Q07837
initial amount: NaN
has part: P82251
constant: false
is encoded by: hsa:6519
has only substance units: false
is encoded by: hsa:11136
type: Species
initial concentration: NaN
name: SLC7A9:SLC3A1
is: SBO:0000297
boundary condition: true

metaM CE2433 m
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: SBO:0000247
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
is: CHEBI:57795

metaM chol e
name: Choline
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: C00114
is: HMDB00097
constant: false
boundary condition: false
is: CHEBI:15354
initial amount: NaN
type: Species

metaR r0651
fast: false
is: SBO:0000176
product: MODEL1310110005#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
is version of: http://identifiers.org/ec-code/1.5.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
type: Reaction
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true

metaM prpp c
type: Species
is: C00119
has only substance units: false
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: SBO:0000247
name: 5-Phospho-alpha-D-ribose 1-diphosphate
is: CHEBI:58017
constant: false
initial amount: NaN
boundary condition: false
is: HMDB00280
initial concentration: 1.0

metaR r1563
reactant: MODEL1310110005#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110005#

metaM ahcys c
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:16680
is: SBO:0000247
is: C00021
initial concentration: 1.0
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
has only substance units: false
is: HMDB00939
type: Species
name: S-Adenosyl-L-homocysteine

metaR NTD6
is version of: http://identifiers.org/ec-code/3.1.3.5
product: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
modifier: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
fast: false
reversible: false
name: 5'-nucleotidase (dAMP)
is described by: ECO:0000134
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_032bcd64_731e_4434_81d1_0b27a854d83d
is encoded by: hsa:10637
name: LEFTY1
type: Species
initial amount: NaN
has only substance units: false
constant: false
is: O75610
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR MAL Lte
type: Reaction
fast: false
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000185
name: Transport of L-malate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110005#

metaR r0549
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.1.1.17
product: MODEL1310110005#
reversible: true
modifier: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.6.99.3
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.6.5.3
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_856d7406_2477_483b_816c_f0d359763fdc
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:55350
is: SBO:0000252
initial amount: NaN
type: Species
name: VNN3

metaM thcholstoic c
constant: false
is: HMDB03873
is: CHEBI:18402
is: SBO:0000247
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
has only substance units: false
initial concentration: 1.0
type: Species

metaM pan4p e
type: Species
is: HMDB01416
constant: false
is: CHEBI:47942
initial concentration: 1.0
has only substance units: false
name: Pantetheine 4'-phosphate
boundary condition: false
is: C01134
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_9baa6b67_944b_4a87_a93b_2bab11dc26f5
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaM lac L c
initial amount: NaN
is: SBO:0000247
name: (S)-lactate
constant: false
boundary condition: false
is: HMDB00190
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
is: CHEBI:16651
has only substance units: false

metaM 1pipdn2c x
initial amount: NaN
name: 1-piperideine-2-carboxylate
constant: false
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:16187
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
is: HMDB01084
initial concentration: 1.0

metaR r1666
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
type: Reaction
is described by: ECO:0000000

metaR r1568
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110005#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
reversible: true

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_eb49fbaf_60d8_4ead_817b_4b6b45494118
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
name: PC
initial amount: NaN
is encoded by: hsa:5091

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaM alpam m
is: SBO:0000247
is: HMDB06239
name: S-aminomethyldihydrolipoamide
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_e3652469_2854_433d_9038_57a540affe71
is encoded by: hsa:AA021081
initial concentration: NaN
constant: false
is: SBO:0000252
name: _AA021081_1_r
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_e1fae798_2508_4848_97d8_c47401c88e5a
is: B2RA41
constant: false
is encoded by: hsa:6554
name: SLC10A1
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaM frdp c
constant: false
initial amount: NaN
name: Farnesyl diphosphate
type: Species
is: C00448
initial concentration: 1.0
is: HMDB00961
boundary condition: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_1a070639_43a7_41a7_9f77_7176be930d06
type: Species
name: ACSS1
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:84532
initial amount: NaN
is: Q9NUB1
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_6a8e5954_d7b9_42b9_aeb6_5a591f67b80a
is: P49753
name: ACOT2
is encoded by: hsa:10965
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaM nadh m
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:57945
is: HMDB01487
constant: false
initial concentration: 1.0
is: C00004
is: http://identifiers.org/pubchem.compound/3306
is: SBO:0000247
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false

metaM gthox m
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: CHEBI:58297
type: Species
is: HMDB03337
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0

metaM ins e
has only substance units: false
name: Inosine
is: C00294
is: SBO:0000247
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: CHEBI:17596
is: HMDB00195

http://identifiers.org/biomodels.db/MODEL1310110005#_d0bdd5b1_f864_44c1_9841_fc1dfcfe09f7
name: NME1
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:4830
type: Species
is: SBO:0000252

metaM 2pg c
type: Species
boundary condition: false
is: C00631
name: D-Glycerate 2-phosphate
is: SBO:0000247
is: CHEBI:58289
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: 1/C3H7O7P/c4-1-2(3(5)6)10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1/f/h5,7-8H HEPATONET_1.0_ABBREVIATION: HC00463 EHMN_ABBREVIATION: C00631
is: http://identifiers.org/pubchem.compound/3904
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB03391

metaR r1665
type: Reaction
modifier: MODEL1310110005#
is described by: ECO:0000000
fast: false
reversible: true
name: Y+LAT2 Utilized transport
reactant: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110005#
kinetic law: MODEL1310110005#

metaM HC01397 m
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
name: (S)-3-Hydroxyhexadecanoyl-CoA
boundary condition: false
initial amount: NaN
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
is: CHEBI:27402

metaR GTHP
kinetic law: MODEL1310110005#
reversible: true
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.12
name: glutathione peroxidase
is version of: http://identifiers.org/ec-code/1.11.1.9
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.11.1.15
product: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
reactant: MODEL1310110005#
type: Reaction

metaM leuktrA4 c
is: SBO:0000247
name: leukotriene A4(1-)
is: HMDB01337
initial concentration: 1.0
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
has only substance units: false
type: Species
constant: false
boundary condition: false
is: CHEBI:57463
initial amount: NaN

metaR r1569
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110005#
product: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_42849c9d_9e77_41a0_8221_974a1a96b230
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
name: PRDX2
type: Species
is: SBO:0000252
is encoded by: hsa:7001
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_f939c128_0a7a_429f_94d2_3a775675fc51
is encoded by: hsa:51166
has only substance units: false
is: SBO:0000252
type: Species
is: Q8N5Z0
name: AADAT
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

metaM chol c
initial amount: NaN
is: CHEBI:15354
constant: false
has only substance units: false
name: Choline
is: HMDB00097
is: C00114
is: SBO:0000247
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
boundary condition: false
initial concentration: 1.0

metaR r2516
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
reactant: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaM c226coa c
is: C16169
is: SBO:0000247
has only substance units: false
boundary condition: false
name: cervonyl coenzyme A
type: Species
is: http://identifiers.org/pubchem.compound/47205479
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
constant: false
initial amount: NaN

metaM acac m
name: acetoacetate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:13705
has only substance units: false
is: HMDB00060
is: SBO:0000247
constant: false
type: Species

metaM Lcystin c
constant: false
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: L-cystine
is: CHEBI:16283
is: HMDB00192
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1

metaR r1664
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
modifier: MODEL1310110005#
name: Y+LAT2 Utilized transport
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_ab2f1d30_96d0_4f64_9147_ae5c5f75e583
is encoded by: hsa:10797
is: P13995
boundary condition: true
is: SBO:0000252
type: Species
name: MTHFD2
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false

metaR r1566
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110005#
fast: false
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaM lac L e
has only substance units: false
name: (S)-lactate
is: HMDB00190
boundary condition: false
type: Species
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
initial concentration: 1.0
is: CHEBI:16651
initial amount: NaN
is: SBO:0000247
constant: false

metaM dgmp e
name: dGMP(2-)
initial concentration: 1.0
is: HMDB01044
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: CHEBI:57673
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
type: Species

metaR TCYNTt
name: Thiocyanate transport via diffusion (cytosol to extracellular)
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
reactant: MODEL1310110005#
is: SBO:0000185
type: Reaction
product: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#

metaR r0656
reversible: false
is described by: ECO:0000000
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
type: Reaction
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
is: SBO:0000176
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_5299d769_d0aa_48ac_9c5b_9332ec724bbb
boundary condition: true
initial amount: NaN
is encoded by: hsa:5161
initial concentration: NaN
is: SBO:0000252
name: PDHA2
is: P29803
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_c4ac1283_e73e_4a68_aa5b_a4b4f88643f3
is: SBO:0000252
is encoded by: hsa:11332
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: ACOT7
is: O00154
boundary condition: true
initial concentration: NaN

metaR 3MOBt2im
product: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reversible: false
fast: false
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_dc6cf514_5d5a_4e02_8d2b_8fcce960d26d
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110005#_3e7c126e_a244_4bfe_af86_d656ee59a064
name: SLC25A15
type: Species
constant: false
is: Q9Y619
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:10166
is: SBO:0000252
initial amount: NaN

metaM ins c
is: C00294
is: CHEBI:17596
is: SBO:0000247
type: Species
name: Inosine
has only substance units: false
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial concentration: 1.0
constant: false
is: HMDB00195
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_0bb9daf5_f4dc_47f9_b9f3_14fd22347bd8
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is: P11908
initial concentration: NaN
type: Species
is encoded by: hsa:5634
name: PRPS2

metaR ASPTA
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
product: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true
name: aspartate transaminase
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.1
type: Reaction

metaM cmpacna c
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
has only substance units: false
type: Species
constant: false
is: HMDB01176
name: CMP-N-acetyl-beta-neuraminate(2-)
is: CHEBI:57812
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR r1567
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110005#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110005#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_de6717f5_1b67_4b65_8c15_be63dd6a4c93
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:W87865
boundary condition: true
initial amount: NaN
name: _W87865_1_c
is: SBO:0000252
type: Species

metaM leuktrA4 e
name: leukotriene A4(1-)
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
has only substance units: false
boundary condition: false
is: CHEBI:57463
initial amount: NaN
is: SBO:0000247
is: HMDB01337

http://identifiers.org/biomodels.db/MODEL1310110005#_f9e49f53_ec80_40ad_a09b_aefecc67729e
constant: false
boundary condition: true
type: Species
name: UCKL1
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:54963
is: Q53HM1

metaR r0655
is: SBO:0000176
product: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000000
fast: false
reversible: true
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:

metaR r0545
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
is: SBO:0000176
reversible: true
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:

metaM thp2c c
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
is: SBO:0000247
constant: false
name: 1-piperideine-6-carboxylate
is: CHEBI:16987
has only substance units: false
is: HMDB12130
initial amount: NaN

metaM oxa c
initial amount: NaN
has only substance units: false
is: CHEBI:30623
name: oxalate(2-)
initial concentration: 1.0
is: HMDB02329
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: SBO:0000247
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_39774ac7_e61c_4be5_ba5a_cf3a3d2f81ca
initial amount: NaN
constant: false
is encoded by: hsa:18
has only substance units: false
type: Species
is: SBO:0000252
is: P80404
initial concentration: NaN
boundary condition: true
name: ABAT

metaR EX ahcys LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of S-adenosyl-L-homocysteine
type: Reaction

metaR ACACt2m
is: SBO:0000185
is described by: ECO:0000269
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
product: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
name: Acetoacetate mitochondrial transport via H+ symport

metaR NODe
kinetic law: MODEL1310110005#
reversible: true
is described by: ECO:0000134
fast: false
name: NODe
is: SBO:0000185
type: Reaction
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_e722d22d_0723_4860_a81d_50ae123dc658
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: HAO2
is encoded by: hsa:51179
constant: false
boundary condition: true
type: Species
has only substance units: false

metaM glyclt c
type: Species
boundary condition: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
is: CHEBI:29805
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00115
name: glycolate
initial concentration: 1.0

metaR CYTK2
fast: false
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000176
type: Reaction
name: cytidylate kinase (dCMP)

http://identifiers.org/biomodels.db/MODEL1310110005#_81602962_fc81_41d9_abb0_507fe4121264
initial concentration: NaN
is encoded by: hsa:3157
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q01581
has only substance units: false
constant: false
name: HMGCS1
type: Species

metaR CGLYt3 2
type: Reaction
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
is described by: ECO:0000304
name: Cys-Gly transport in via proton symport
reversible: false
kinetic law: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
is: SBO:0000185
reactant: MODEL1310110005#

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_7b554bcd_7b92_4cdb_bffb_f16e78daf7da
name: SUCLG2
boundary condition: true
constant: false
is encoded by: hsa:8801
is: Q96I99
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR ECOAH9m
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
product: MODEL1310110005#
reversible: true
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
reactant: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity

http://identifiers.org/biomodels.db/MODEL1310110005#_9d2dfada_c494_49e7_a62e_1653fef18c25
constant: false
initial amount: NaN
boundary condition: true
name: HSD17B10
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3028
initial concentration: NaN
is: Q99714
type: Species

metaM pglyc hs e
is: SBO:0000247
name: phosphatidylglycerol(1-)
is: CHEBI:60523
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_e6617643_ca1e_46fa_91d6_2a9b2be3acb2
name: _FLJ44968_1_m
has only substance units: false
is: SBO:0000252
is encoded by: hsa:FLJ44968
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

metaM idp n
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB03335
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58280
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
name: IDP(3-)
type: Species

metaM nad r
is: HMDB00902
type: Species
name: NAD(1-)
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
is: CHEBI:57540
initial amount: NaN
constant: false
has only substance units: false

metaR CYTK1
name: cytidylate kinase (CMP)
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110005#
reversible: true
reactant: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#

metaM ile L c
boundary condition: false
is: HMDB00172
is: CHEBI:17191
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
type: Species
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
name: L-isoleucine

metaR ACGAMtly
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
reactant: MODEL1310110005#
is: SBO:0000185
reversible: false
name: N-acetyl-glucosamine lysosomal efflux
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_a20438d4_b16a_44d5_9f59_c135a30c73b7
is: SBO:0000252
name: HMGCL
boundary condition: true
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: Q6IBC0
is encoded by: hsa:3155
initial amount: NaN

metaM gly e
constant: false
is: C00037
is: CHEBI:3339
boundary condition: false
is: SBO:0000247
has only substance units: false
name: Glycine
initial concentration: 1.0
is: HMDB00123
notes: FORMULA: C2H5NO2 CHARGE: 0
initial amount: NaN
type: Species

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaR RE1521M
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
fast: false
product: MODEL1310110005#
modifier: MODEL1310110005#
name: RE1521
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110005#

metaM dctp n
is: CHEBI:16311
is: HMDB00998
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
name: dCTP
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: C00458
constant: false
has only substance units: false

metaM retinol cis 11 c
initial concentration: 1.0
constant: false
name: 11-cis-retinol
is: HMDB06216
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
is: CHEBI:16302

metaR PYK
fast: false
kinetic law: MODEL1310110005#
is: SBO:0000176
product: MODEL1310110005#
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.1.40
name: pyruvate kinase
reversible: false
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_e523c6bc_a91f_4047_8406_0757f1d145c1
boundary condition: true
is: P61457
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5092
initial amount: NaN
type: Species
constant: false
name: PCBD1
has only substance units: false

metaR DHFR
kinetic law: MODEL1310110005#
name: dihydrofolate reductase
reversible: true
is described by: ECO:0000254
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
type: Reaction
modifier: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176

metaM pan4p m
boundary condition: false
is: CHEBI:47942
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
constant: false
initial concentration: 1.0
has only substance units: false
name: pantetheine 4'-phosphate(2-)
is: HMDB01416
initial amount: NaN
type: Species
is: SBO:0000247

metaM acac c
constant: false
is: CHEBI:13705
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00060
name: acetoacetate
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
boundary condition: false

metaR r0647
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
product: MODEL1310110005#
fast: false
is: SBO:0000176
type: Reaction
name: Spontaneous reaction

metaM bildglcur c
initial amount: NaN
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:58471
is: HMDB03325
type: Species
constant: false

metaM pglyc hs c
is: CHEBI:60523
is: SBO:0000247
type: Species
notes: FORMULA: C6H12O6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02096
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: phosphatidylglycerol(1-)
constant: false

metaM 2maacoa m
constant: false
has only substance units: false
is: HMDB01157
is: SBO:0000247
is: CHEBI:57335
initial amount: NaN
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
name: 2-methylacetoacetyl-CoA(4-)
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_536e9532_10e3_4d8a_87a0_7722499562f0
name: ENPP1
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:5167
is: P22413
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_a7dc971c_1f0c_4faa_8eb4_792dda1a0348
name: VNN3
type: Species
is encoded by: hsa:55350
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN

metaM ile L e
boundary condition: false
is: CHEBI:17191
is: SBO:0000247
is: HMDB00172
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
name: L-isoleucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407

metaM 4aphdob c
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00978
initial concentration: 1.0
is: CHEBI:58147
name: 4-(2-aminophenyl)-2,4-dioxobutanoate

http://identifiers.org/biomodels.db/MODEL1310110005#_b1ec4903_1930_4fa8_b6b8_1f7da9fc2f0a
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:7083
initial concentration: NaN
boundary condition: true
is: P04183
has only substance units: false
name: TK1
constant: false

metaR r0317
reversible: true
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false
modifier: MODEL1310110005#
is: SBO:0000176
product: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_7cad30df_77e4_49bc_8e07_2550df8e5fed
is: SBO:0000252
is: Q6IRT1
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: ADH5
type: Species
initial concentration: NaN
is encoded by: hsa:128

metaM gly c
has only substance units: false
boundary condition: false
constant: false
name: Glycine
is: C00037
is: CHEBI:3339
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C2H5NO2 CHARGE: 0
is: HMDB00123
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_d114b88a_9b8f_4596_a279_bef7d91590ab
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:HG2846-HT2983
initial concentration: NaN
name: _HG2846_HT2983_1_c

metaR r0181
kinetic law: MODEL1310110005#
is described by: ECO:0000000
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
reversible: true
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
modifier: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
reactant: MODEL1310110005#

metaM crn m
name: L-Carnitine
is: C00318
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062
is: CHEBI:16347
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_ef14b8af_2337_4373_8094_23a20b1b5bfe
boundary condition: true
type: Species
is encoded by: hsa:10400
name: PEMT
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM thp2c x
is: CHEBI:16987
is: SBO:0000247
boundary condition: false
name: 1-piperideine-6-carboxylate
initial concentration: 1.0
is: HMDB12130
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
initial amount: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_8f18052f_3149_4a8f_a894_4e0ac1b23419
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:376497
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
name: SLC27A1

metaR DESAT18 3
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reactant: MODEL1310110005#
is described by: ECO:0000269
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
product: MODEL1310110005#
is: SBO:0000176
modifier: MODEL1310110005#
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.14.19.1
kinetic law: MODEL1310110005#

metaM acac e
type: Species
boundary condition: false
is: CHEBI:13705
initial amount: NaN
is: HMDB00060
is: SBO:0000247
initial concentration: 1.0
name: acetoacetate
has only substance units: false
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaR CYTK6
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000269
fast: false
product: MODEL1310110005#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110005#
name: cytidylate kinase (CMP,CTP)
reversible: true

metaR r2024
is: SBO:0000185
product: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
kinetic law: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
reversible: false
type: Reaction
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM HC01376 m
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:28692
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118
initial concentration: 1.0
is: SBO:0000247
name: S-(2-Methylbutanoyl)-dihydrolipoamide
has only substance units: false

metaR CYTK7
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reversible: true
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110005#
modifier: MODEL1310110005#
name: cytidylate kinase (CMP,UTP)
is: SBO:0000176
reactant: MODEL1310110005#

metaM gthox e
initial amount: NaN
is: CHEBI:58297
has only substance units: false
is: HMDB03337
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
type: Species

metaR r1561
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_b320ecdf_c858_4c51_bbfc_68644933b0b6
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:27068
constant: false
initial concentration: NaN
name: PPA2
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_4368dd46_4af0_4c4c_993d_be82dba96a2a
is: Q546H9
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: ALDH5A1
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:7915

http://identifiers.org/biomodels.db/MODEL1310110005#_2df3d9c4_f64b_4b50_a80c_5ab9d2f5ed97
initial concentration: NaN
type: Species
is: SBO:0000297
has part: Q9UHI5
name: SLC7A8:SLC3A2
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:23428

metaR r1917
is: SBO:0000185
modifier: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110005#_7f8d78a7_fd37_4d0b_84ce_407b476d816f
is: SBO:0000252
is: Q9NVE7
is encoded by: hsa:55229
initial concentration: NaN
initial amount: NaN
constant: false
name: PANK4
type: Species
has only substance units: false
boundary condition: true

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_a4640d20_7d95_4d53_8435_75870e694345
initial amount: NaN
has only substance units: false
is: Q9P0Z9
is encoded by: hsa:51268
is: SBO:0000252
constant: false
initial concentration: NaN
name: PIPOX
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_772d7e84_9b5d_4963_9012_19929660bd5b
boundary condition: true
is encoded by: hsa:6901
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
name: TAZ
initial concentration: NaN
is: Q16635

metaR CYTK5
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000269
reversible: true
fast: false
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP)
is: SBO:0000176
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction

metaR NTD7
fast: false
product: MODEL1310110005#
reactant: MODEL1310110005#
reversible: false
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
name: 5'-nucleotidase (AMP)

metaR r2308
reversible: true
fast: false
type: Reaction
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

metaR ME2m
fast: false
is: SBO:0000176
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.38
name: malic enzyme (NADP), mitochondrial
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.40
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#

metaM succ m
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C00042
name: Succinate
initial amount: NaN
is: CHEBI:30031
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: HMDB00254

metaR r0202
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
type: Reaction
reactant: MODEL1310110005#
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
fast: false
product: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000176

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR r1560
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110005#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110005#
is: SBO:0000185
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_befe6b70_a2d2_4097_bd30_cb86b804886f
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q9GZV3
name: SLC5A7
initial amount: NaN
boundary condition: true
is encoded by: hsa:60482
constant: false

metaR FOLR2
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110005#
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
name: folate reductase
is version of: http://identifiers.org/ec-code/1.5.1.3
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110005#_b28ed8ed_fae4_4a07_9230_1b0bce637a1e
initial amount: NaN
has only substance units: false
is encoded by: hsa:56954
is: Q9NQR4
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: NIT2

metaR r1914
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110005#
modifier: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
reversible: false
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110005#

metaR GLYCt
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#
reversible: true
type: Reaction
name: glycerol transport via channel
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110005#

metaM nadph r
initial concentration: 1.0
boundary condition: false
is: C00005
is: CHEBI:57783
is: HMDB00221
constant: false
type: Species
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_90451f07_ef09_4a15_9b60_a1ac5375906f
type: Species
initial concentration: NaN
name: _AV717590_1_c
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:AV717590
constant: false

metaR CYTK4
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000269
name: cytidylate kinase (dCMP)(GTP)
is: SBO:0000176
type: Reaction
reversible: true

metaR r2388
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000185
reversible: false
fast: false
reactant: MODEL1310110005#
product: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110005#_8cd23889_3d78_45ac_85e4_3196fbc6e65a
type: Species
initial concentration: NaN
is: P36269
name: GGT5
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:2687
initial amount: NaN

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_b55e05dc_a3e9_479f_af85_cbe2f199912f
has only substance units: false
initial amount: NaN
name: TXNRD1
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:7296

metaM gthox c
name: Oxidized glutathione
has only substance units: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: CHEBI:58297
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB03337
is: C00127
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_be5ea37f_6a36_438f_b8d4_a3e9578be60b
has only substance units: false
is: Q5QPH3
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: ACSS2
boundary condition: true
is encoded by: hsa:55902
constant: false

metaR ORNt3m
type: Reaction
product: MODEL1310110005#
modifier: MODEL1310110005#
is: SBO:0000185
name: ornithine mitochondrial transport via proton antiport
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
is described by: ECO:0000269
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_417e1711_61b1_4cfa_abf2_9e4c998861e7
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
is: P54819
type: Species
name: AK2
initial concentration: NaN
is encoded by: hsa:204
is: SBO:0000252

metaR LYStm
modifier: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000269
name: Lysine mitochondrial transport via ornithine carrier
product: MODEL1310110005#
kinetic law: MODEL1310110005#

metaR CAATPS
is version of: http://identifiers.org/ec-code/3.6.3.8
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
fast: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110005#
is: SBO:0000185
name: Ca ATPase
reactant: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: false

metaR UDPGLCAter
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
reactant: MODEL1310110005#
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
fast: false
kinetic law: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD

metaM crn r
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
has only substance units: false
is: CHEBI:16347
is: HMDB00062
is: SBO:0000247
boundary condition: false
name: (R)-carnitine
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_3562b752_7909_40bb_853c_d28c16fdb812
boundary condition: true
is: Q86YI5
has only substance units: false
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:1737
name: DLAT
is: SBO:0000252
initial concentration: NaN

metaR CYTK3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
modifier: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
reversible: true
fast: false
is described by: ECO:0000269
name: cytidylate kinase (CMP)(GTP)
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#

metaR VALTAm
is described by: ECO:0000269
kinetic law: MODEL1310110005#
name: valine transaminase, mitochondiral
reversible: true
reactant: MODEL1310110005#
product: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
type: Reaction

metaR r2389
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110005#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_e2fd45a3_e6ff_4e1c_a6a9_f4652bb61b4d
boundary condition: true
name: GK
initial concentration: NaN
is encoded by: hsa:2710
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is: B4DH54
constant: false

metaM q10h2 m
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
name: Ubiquinol-10
has only substance units: false
is: http://identifiers.org/pubchem.compound/6504740
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: HMDB13111

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_1250f5a8_109b_4919_9868_bc2018f78cd8
has only substance units: false
name: GPX1
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2876
constant: false

metaM odecoa m
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01322
constant: false
name: Octadecenoyl-CoA (n-C18:1CoA)
is: CHEBI:57387
initial amount: NaN
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
has only substance units: false

metaM HC02205 e
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial amount: NaN
constant: false
type: Species
boundary condition: false
name: prostaglandin-b2
has only substance units: false
is: CHEBI:28099

metaR r0186
is described by: ECO:0000000
modifier: MODEL1310110005#
reversible: false
product: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
kinetic law: MODEL1310110005#

metaM oxa m
is: CHEBI:30623
has only substance units: false
name: oxalate(2-)
initial amount: NaN
is: SBO:0000247
is: HMDB02329
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
constant: false

metaM trp L c
is: SBO:0000247
constant: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
boundary condition: false
name: L-tryptophan
initial concentration: 1.0
is: HMDB00929
has only substance units: false
is: CHEBI:16828
initial amount: NaN
type: Species

metaR NMNATr
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.7.1
name: nicotinamide-nucleotide adenylyltransferase
is described by: ECO:0000269
reactant: MODEL1310110005#
reversible: true
product: MODEL1310110005#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false

metaR r0310
is described by: ECO:0000000
reversible: false
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
product: MODEL1310110005#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_c0099e72_cee4_4c26_9bd3_9aa425be1d6e
name: CPT1C
initial amount: NaN
is encoded by: hsa:126129
is: Q8TCG5
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_70292f87_c4b6_421d_833f_3646e8f74d97
initial concentration: NaN
is encoded by: hsa:1375
type: Species
is: E9PCP2
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
name: CPT1B
has only substance units: false

metaR r2386
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110005#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reversible: false
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
modifier: MODEL1310110005#

metaR r0074
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_69b1156c_3cdb_4e89_aeae_e1095a653c0a
is encoded by: hsa:203
is: P00568
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: AK1
is: SBO:0000252

metaM gly m
boundary condition: false
initial concentration: 1.0
is: HMDB00123
is: CHEBI:15428
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
name: Glycine
is: C00037
has only substance units: false

metaR r0311
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
is: SBO:0000176
modifier: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000
product: MODEL1310110005#

metaM C05280 m
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB03952
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
name: cis,cis-3,6-Dodecadienoyl-CoA
is: CHEBI:28002

metaR r2387
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
reactant: MODEL1310110005#

metaM idp e
is: SBO:0000247
constant: false
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
type: Species
initial concentration: 1.0
is: CHEBI:58280
is: HMDB03335
initial amount: NaN
boundary condition: false
has only substance units: false

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR EX 2mcit LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Methylcitrate exchange
type: Reaction

metaM lac L x
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:16651
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: HMDB00190
has only substance units: false
boundary condition: false
name: (S)-lactate
constant: false

metaR TTDCAFATPc
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaR r0881
type: Reaction
product: MODEL1310110005#
name: Active transport
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110005#
reversible: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:

metaM trp L e
is: SBO:0000247
constant: false
boundary condition: false
name: L-tryptophan
is: HMDB00929
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial concentration: 1.0
is: CHEBI:16828
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_3b42558c_152d_4241_8df1_2ec06a730179
has part: P11177
has only substance units: false
boundary condition: true
is encoded by: hsa:5162
has part: Q86YI5
initial amount: NaN
has part: O00330
type: Species
has part: P29803
initial concentration: NaN
is encoded by: hsa:8050
is: SBO:0000297
name: DLAT:DLD:PDHA2:PDHB:PDHX
constant: false
is encoded by: hsa:1737
is encoded by: hsa:5161

http://identifiers.org/biomodels.db/MODEL1310110005#_48cf964a_3eda_4ebe_82e9_5c18555a94d4
is: SBO:0000252
initial concentration: NaN
is: B7Z4Y6
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:249
name: ALPL

http://identifiers.org/biomodels.db/MODEL1310110005#_2f897930_e57a_455e_b7bf_88798b58f0dc
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P48448
has only substance units: false
is encoded by: hsa:222
type: Species
constant: false
name: ALDH3B2

metaR CDPDAGtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reactant: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
name: intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reversible: true
fast: false

metaR PGDI
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/5.3.99.2
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
name: Prostaglandin-H2 D-isomerase [Precursor]
type: Reaction
kinetic law: MODEL1310110005#
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.5.1.18
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110005#_9372df7f_e811_4c9b_be4d_1977ceb034b9
initial amount: NaN
type: Species
initial concentration: NaN
is: P55084
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3032
name: HADHB
constant: false
boundary condition: true

metaR r2026
reversible: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110005#
is: SBO:0000185
modifier: MODEL1310110005#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR PSt3
name: phosphatidylserine transport
product: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110005#
reversible: true
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_93855380_5e3f_4500_8833_2c2eea6663b3
name: GLUD1
initial concentration: NaN
is: E9KL48
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:2746
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_6c6e60f0_280a_48e6_b519_aecf93c112a9
is: SBO:0000252
is: Q9H903
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:441024
initial concentration: NaN
has only substance units: false
name: MTHFD2L
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_f77f48cf_3a18_4cfa_a368_aab0f7653bd7
is: Q53HE2
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: TPI1
is encoded by: hsa:7167
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_2786da0b_d203_48af_be64_fb23bc6be555
has only substance units: false
is: P05091
name: ALDH2
is encoded by: hsa:217
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaR CHOLATEt
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
reversible: true
modifier: MODEL1310110005#
fast: false
name: cholate transport via bicarbonate countertransport
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction

metaR r2384
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
type: Reaction
reversible: false
product: MODEL1310110005#
is described by: ECO:0000000
modifier: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM HC01496 m
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
initial concentration: 1.0
is: CHEBI:28095
name: 2-Amino-3-oxoadipate

metaR DPCOAPPe
is described by: ECO:0000134
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
name: Pyrophasphatase (dephospho-CoA, extracellular)
kinetic law: MODEL1310110005#
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_59153ccc_a547_4566_870a_b495c3788b85
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AA788780
name: _AA788780_1_c
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_badcbd40_807b_4c07_b69e_aa35a590b223
initial concentration: NaN
initial amount: NaN
name: SLC26A8
type: Species
has only substance units: false
constant: false
is encoded by: hsa:116369
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_3459b1b5_437f_4b15_a5f8_e04a25e53bec
has part: Q92536
constant: false
name: SLC3A2:SLC7A6
is: SBO:0000297
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:9057

metaR HPYRR2x
is described by: ECO:0000304
is: SBO:0000176
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/1.1.2.4
modifier: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.27
product: MODEL1310110005#
kinetic law: MODEL1310110005#
name: hydroxypyruvate reductase (NADH)

metaR ARACHDCOAtx
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110005#
is: SBO:0000185
name: fatty acid intracellular transport
fast: false

metaR C226CRNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000000
name: C226 transport into the mitochondria
reversible: false
kinetic law: MODEL1310110005#
is: SBO:0000185
reactant: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
fast: false

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaM idp c
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:58280
initial concentration: 1.0
name: IDP(3-)
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: HMDB03335
is: SBO:0000247

metaM sph1p c
constant: false
type: Species
boundary condition: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: CHEBI:57939
initial amount: NaN
is: HMDB01383
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM gua c
is: C00242
name: Guanine
initial amount: NaN
is: HMDB00132
is: CHEBI:16235
is: SBO:0000247
has only substance units: false
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
boundary condition: false
type: Species
initial concentration: 1.0
constant: false

metaM ile L m
initial concentration: 1.0
constant: false
is: CHEBI:17191
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00172
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
name: L-isoleucine
initial amount: NaN

metaR r2385
reactant: MODEL1310110005#
reversible: false
kinetic law: MODEL1310110005#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
modifier: MODEL1310110005#
is described by: ECO:0000000
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_9f4cb810_b923_4b75_8dda_9b2be0c38c95
initial concentration: NaN
initial amount: NaN
name: _AA177072_1_c
has only substance units: false
is encoded by: hsa:AA177072
type: Species
constant: false
is: SBO:0000252
boundary condition: true

metaR GLYCTDle
reactant: MODEL1310110005#
product: MODEL1310110005#
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110005#
type: Reaction
name: difussion of glycerol accross the brush border membrane
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110005#_bf39acfe_3514_4244_8b0c_125c2cbbdb2b
name: ALDH1B1
type: Species
initial concentration: NaN
is encoded by: hsa:219
constant: false
has only substance units: false
is: P30837
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM prostge1 c
constant: false
initial concentration: 1.0
is: HMDB01442
name: prostaglandin E1(1-)
is: CHEBI:57397
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false

metaR NDPK1m
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110005#
fast: false
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
is: SBO:0000176
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
type: Reaction
reactant: MODEL1310110005#
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110005#_003dbe7f_9a9d_4f08_a3c0_264c4bc790d3
name: SLC7A10:SLC3A2
initial concentration: NaN
has part: P08195
type: Species
is: SBO:0000297
initial amount: NaN
constant: false
is encoded by: hsa:6520
is encoded by: hsa:56301
has only substance units: false
boundary condition: true
has part: Q9NS82

metaR biomass reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
name: biomass_reaction
fast: false
product: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000134
reversible: false

metaR r0937
name: Transport reaction
type: Reaction
reversible: true
fast: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

metaR r2382
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
modifier: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110005#
reversible: false
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_52d1d111_ff47_4107_8191_69abdd576472
has only substance units: false
initial concentration: NaN
name: VNN3
initial amount: NaN
type: Species
is encoded by: hsa:55350
constant: false
boundary condition: true
is: SBO:0000252

metaM dctp c
is: CHEBI:16311
initial amount: NaN
is: SBO:0000247
is: HMDB00998
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
boundary condition: false
has only substance units: false
type: Species
is: C00458
constant: false
initial concentration: 1.0
name: dCTP

http://identifiers.org/biomodels.db/MODEL1310110005#_d66498db_c23d_4ec9_b1d0_757598450a0e
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: _AI694761_1_c
is encoded by: hsa:AI694761
has only substance units: false
is: SBO:0000252
constant: false

metaM bildglcur e
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:58471
name: bis(beta-glucosyluronate)bilirubin
has only substance units: false
is: HMDB03325
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787

metaR ACNAMtn
is described by: ECO:0000000
name: N-acetylneuraminate nuclear import
reactant: MODEL1310110005#
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_b59beea2_16a5_4e03_8391_1fa241fb3616
initial amount: NaN
name: SLC7A8
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
is: Q9UHI5
has only substance units: false
is encoded by: hsa:23428

metaM odecoa c
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01322
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
boundary condition: false
name: Octadecenoyl-CoA (n-C18:1CoA)
initial concentration: 1.0
is: CHEBI:3793

metaM CE2417 m
is: CHEBI:28387
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB11123
initial concentration: 1.0
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
initial amount: NaN
boundary condition: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_c2de8972_aeef_4fde_9af4_09b85ea2bfaa
is encoded by: hsa:6575
boundary condition: true
constant: false
name: SLC20A2
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: B2RBR4
initial concentration: NaN

metaR DHPM1
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.2.2
type: Reaction
product: MODEL1310110005#
name: dihydropyrimidinase (5,6-dihydrouracil)
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
fast: false
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
reactant: MODEL1310110005#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110005#_75b29871_5eac_479b_ad4e_de5c51ba9ac7
initial amount: NaN
is: Q9NUB1
name: ACSS1
is encoded by: hsa:84532
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252

metaR NDPK1n
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
modifier: MODEL1310110005#
is: SBO:0000176
product: MODEL1310110005#
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_f0c09199_021b_459b_9c3a_3418de73608e
is: Q9UN76
type: Species
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:11254
name: SLC6A14
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR r0936
is described by: ECO:0000000
reactant: MODEL1310110005#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110005#
kinetic law: MODEL1310110005#
name: Transport reaction

metaM gua e
boundary condition: false
name: guanine
is: CHEBI:16235
initial amount: NaN
initial concentration: 1.0
is: HMDB00132
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
type: Species
is: SBO:0000247
has only substance units: false
constant: false

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

metaM crn x
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
name: L-Carnitine
is: HMDB00062
is: C00318
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM q10h2 c
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/6504740
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB13111
name: Ubiquinol-10
is: SBO:0000247
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324

metaR CYSGLYexR
fast: false
modifier: MODEL1310110005#
reversible: true
is described by: ECO:0000000
type: Reaction
name: L-cysteine/glycine reversible exchanger
reactant: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
kinetic law: MODEL1310110005#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_20ed0e06_cf06_4f45_873f_b44fc58a86a6
constant: false
has only substance units: false
is encoded by: hsa:122622
name: ADSSL1
initial concentration: NaN
is: B3KTV4
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species

metaR P5CR
is described by: ECO:0000134
fast: false
kinetic law: MODEL1310110005#
reversible: false
reactant: MODEL1310110005#
name: pyrroline-5-carboxylate reductase
product: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110005#_9022e03e_c50a_461a_ae27_c9440ffb448c
boundary condition: true
name: _AA526438_1_m
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:AA526438

http://identifiers.org/biomodels.db/MODEL1310110005#_31adf01e_f6b3_425d_a989_9bf13cf3f57e
is encoded by: hsa:5723
is: P78330
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
name: PSPH
type: Species

metaR r0885
type: Reaction
fast: false
product: MODEL1310110005#
is: SBO:0000185
modifier: MODEL1310110005#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.38
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaM nad x
is: HMDB00902
is: C00003
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3305
constant: false
type: Species
is: CHEBI:57540
initial amount: NaN
name: Nicotinamide adenine dinucleotide
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_91930691_df2b_4a22_a953_2f270aa2f937
name: NME2
type: Species
is: SBO:0000252
is encoded by: hsa:4831
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: P22392
boundary condition: true

metaR NDPK9n
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
product: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD

metaM dgdp c
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00960
is: CHEBI:58595
has only substance units: false
is: SBO:0000247
is: C00361
constant: false
name: dGDP

metaM xylu D c
is: HMDB01644
boundary condition: false
is: CHEBI:17140
type: Species
name: D-xylulose
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_2f195030_c915_46a7_a8ef_50e1c0e3ab5d
type: Species
is: SBO:0000252
name: SLC26A9
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:115019
has only substance units: false
is: Q7LBE3
boundary condition: true

metaR r2380
reactant: MODEL1310110005#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM HC01609 e
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
has only substance units: false
constant: false
is: SBO:0000247
type: Species
name: UroporphyrinogenI
is: CHEBI:28766
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaR GCC2cm
reactant: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
name: glycine-cleavage complex (lipoamide), mitochondrial
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.1.2.10
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.4.4.2
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110005#

metaR DADNt4
type: Reaction
kinetic law: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
name: deoxyadenosine transport via diffusion
reactant: MODEL1310110005#

metaR PAIL HStn
product: MODEL1310110005#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
fast: false
name: phosphatidylinositol nuclear transport (diffusion)
type: Reaction
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaR r1809
type: Reaction
reversible: false
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110005#
reactant: MODEL1310110005#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000

metaM q10h2 e
has only substance units: false
is: SBO:0000247
is: HMDB13111
name: Ubiquinol-10
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740

metaM lnlccrn m
initial concentration: 1.0
type: Species
name: Linoleyl carnitine
has only substance units: false
is: HMDB06469
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1

metaR PPD2CSPp
is described by: ECO:0000000
product: MODEL1310110005#
kinetic law: MODEL1310110005#
name: PPD2CSPp
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
fast: false
is: SBO:0000176
reactant: MODEL1310110005#
reversible: false
type: Reaction

metaR r0295
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
product: MODEL1310110005#
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
modifier: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
is: SBO:0000176

metaM succ c
type: Species
name: Succinate
boundary condition: false
is: C00042
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: HMDB00254
is: CHEBI:30031
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR r2381
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false
is: SBO:0000185
type: Reaction
reversible: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110005#

metaR AKGMALtm
modifier: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
kinetic law: MODEL1310110005#
fast: false
name: alpha-ketoglutarate/malate transporter
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110005#
product: MODEL1310110005#

metaM ptth c
boundary condition: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
is: CHEBI:16753
type: Species
initial concentration: 1.0
name: pantetheine
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB03426

http://identifiers.org/biomodels.db/MODEL1310110005#_31c714ea_a2f9_46fb_ae64_3999d6346460
name: PKM2
is: B4DNK4
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5315
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_1741da8f_0438_4f4d_aaa9_e4a7316471a1
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:124637
initial concentration: NaN
constant: false
initial amount: NaN
is: Q6P9G0
has only substance units: false
name: CYB5D1

metaR FATP2t
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
fast: false
name: fatty acid electroneutral transport
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110005#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_3066d1f4_16f3_4be0_a68b_1f816234f0fa
constant: false
initial concentration: NaN
name: CA8
is encoded by: hsa:767
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P35219
type: Species
boundary condition: true

metaM Lkynr c
is: CHEBI:16946
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: HMDB00684
name: L-kynurenine
is: SBO:0000247
has only substance units: false

W3 CDTF: Thu Aug 30 14:48:47 BST 2012

metaR r0801
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
product: MODEL1310110005#
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaR ATP2ter
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
fast: false
product: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
name: AMP/ATP transporter, endoplasmic reticulum
is described by: ECO:0000000

metaM 42A3HP24DB c
boundary condition: false
is: http://identifiers.org/pubchem.compound/7956
is: HMDB04083
has only substance units: false
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
type: Species
initial concentration: 1.0
initial amount: NaN
is: C05645
constant: false
is: SBO:0000247

metaM 3php c
name: 3-phosphonatooxypyruvate(3-)
is: HMDB01024
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:18110
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaM dhf c
has only substance units: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
name: 7,8-Dihydrofolate
is: CHEBI:57451
initial amount: NaN
is: SBO:0000247
is: C00415
initial concentration: 1.0
is: HMDB01056
type: Species
boundary condition: false
constant: false

metaR SERt4
reversible: false
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
product: MODEL1310110005#
is described by: ECO:0000269
name: L-serine via sodium symport
modifier: MODEL1310110005#
is: SBO:0000185
reactant: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
fast: false

metaM CE0713 m
is: CHEBI:30623
is: HMDB02329
name: 3-oxolinoleoyl-CoA
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
initial amount: NaN

metaM h2o2 c
initial concentration: 1.0
is: C00027
has only substance units: false
name: Hydrogen peroxide
boundary condition: false
type: Species
is: HMDB03125
initial amount: NaN
constant: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: CHEBI:16240
is: SBO:0000247

metaM pro L c
has only substance units: false
is: SBO:0000247
name: L-proline
is: HMDB00162
constant: false
initial amount: NaN
type: Species
is: CHEBI:17203
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145

metaR r0423
modifier: MODEL1310110005#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
reactant: MODEL1310110005#
reversible: true
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
fast: false

metaM lnlnca c
constant: false
is: CHEBI:32387
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
type: Species
name: alpha-linolenate
initial amount: NaN
has only substance units: false
is: HMDB01388
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_5909e7e6_3fdd_4775_a823_a0c807348667
is: SBO:0000252
is encoded by: hsa:H17063
initial amount: NaN
name: _H17063_1_c
type: Species
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

metaM glcur r
type: Species
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial concentration: 1.0
initial amount: NaN
name: D-glucuronate
boundary condition: false
is: HMDB00127
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:15748

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaM h2o2 e
boundary condition: false
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
constant: false
is: CHEBI:16240
initial amount: NaN
is: HMDB03125
is: SBO:0000247
name: hydrogen peroxide
initial concentration: 1.0

metaM HC02214 e
is: CHEBI:28852
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false
name: prostaglandin-f1alpha

http://identifiers.org/biomodels.db/MODEL1310110005#_41561754_8b0f_46b8_854c_dea3824809d3
name: NDUFA2
is: O43678
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:4695
constant: false
boundary condition: true

metaR r1559
is: SBO:0000185
reversible: true
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110005#_4650ea3f_6755_4703_bb6b_961fda57e99b
is encoded by: hsa:18
boundary condition: true
type: Species
name: ABAT
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR RDH3a
reactant: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.105
name: retinol dehydrogenase (11-cis,NADPH)
kinetic law: MODEL1310110005#
fast: false
is described by: ECO:0000269
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
modifier: MODEL1310110005#
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.300

http://identifiers.org/biomodels.db/MODEL1310110005#_db6ba2b6_d40d_4781_9132_10d166bbb68f
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:9023
name: CH25H
type: Species
is: O95992
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM man6p c
is: HMDB01078
name: D-Mannose 6-phosphate
has only substance units: false
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
boundary condition: false
is: CHEBI:17369
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_a348de4c_1745_4402_9513_30547c80dafd
is: B3KXN9
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:84890
constant: false
boundary condition: true
name: ADO
has only substance units: false
is: SBO:0000252

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR r2525
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
reactant: MODEL1310110005#
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110005#
product: MODEL1310110005#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

http://identifiers.org/biomodels.db/MODEL1310110005#_cd312773_dd89_492d_aee7_8a85ea57c345
is: SBO:0000252
type: Species
is: P32321
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:1635
has only substance units: false
name: DCTD

metaR ALAtN1
fast: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is: SBO:0000185
product: MODEL1310110005#
name: Alanine transport (Na, H coupled)
modifier: MODEL1310110005#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_c47171a1_17be_481f_bf49_da8921935700
is: Q96BD0
initial concentration: NaN
name: SLCO4A1
boundary condition: true
initial amount: NaN
is encoded by: hsa:28231
type: Species
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_71e1275b_dd3c_4ac4_bcb1_98e19a9dbe7a
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: B1AM93
is encoded by: hsa:4702
name: NDUFA8
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_a55c7284_08fa_47fd_a5c2_aca953d9c682
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q6IBA0
is encoded by: hsa:4725
name: NDUFS5
type: Species

metaR DITPtn
name: dITP nuclear transport
product: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR r1147
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
product: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaR GLYOX
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.6 Confidence Level: 4 AUTHORS: PMID:15117945,PMID:8550579 NOTES:IF
modifier: MODEL1310110005#
fast: false
product: MODEL1310110005#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/3.1.2.6
reactant: MODEL1310110005#
type: Reaction
is: SBO:0000176
name: hydroxyacylglutathione hydrolase
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_9323bb78_f350_485b_b379_f36916af43dc
name: ACSS2
initial amount: NaN
is encoded by: hsa:55902
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: Q5QPH3
is: SBO:0000252
boundary condition: true

metaR r0422
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
type: Reaction
is described by: ECO:0000000
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110005#
reversible: true
fast: false
modifier: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176

metaR NH4tp
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
product: MODEL1310110005#
name: ammonia peroxisomal transport

http://identifiers.org/biomodels.db/MODEL1310110005#_60618c9e_2bfa_4255_b583_5f7052533f69
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _C7orf24_1_m
is encoded by: hsa:C7orf24
type: Species
has only substance units: false
constant: false

metaM ncam e
is: C00153
initial concentration: 1.0
notes: FORMULA: C6H6N2O CHARGE: 0
constant: false
name: Nicotinamide
is: HMDB01406
boundary condition: false
has only substance units: false
is: CHEBI:0
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_990576e5_61b4_41be_867f_907b1f529f62
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q6ZMR3
initial concentration: NaN
is encoded by: hsa:160287
name: LDHAL6A
constant: false
type: Species
is: SBO:0000252

metaM glu L c
type: Species
initial concentration: 1.0
initial amount: NaN
name: L-glutamate(1-)
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:29985
is: HMDB00148
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
constant: false

metaR NRPPHRtu
kinetic law: MODEL1310110005#
name: Norepinephrine uniport
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
product: MODEL1310110005#
is described by: ECO:0000269
reversible: true
type: Reaction
reactant: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_576d47b0_9443_4601_aa35_3858711ecb63
boundary condition: true
has only substance units: false
is: P19440
initial amount: NaN
is encoded by: hsa:2678
is: SBO:0000252
type: Species
name: GGT1
constant: false
initial concentration: NaN

metaM citr L c
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00904
name: L-citrulline
initial concentration: 1.0
type: Species
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: SBO:0000247
is: CHEBI:16349
constant: false

metaR RE1447N
fast: false
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: true
product: MODEL1310110005#
reactant: MODEL1310110005#

metaR CITt4 4
fast: false
type: Reaction
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
is described by: ECO:0000006
reactant: MODEL1310110005#
reversible: true
name: citrate transport via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110005#_80245c90_9f51_4e9e_afce_86f43ef5c8e8
name: CPT1A
is encoded by: hsa:1374
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: Q8WZ48
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_ea16edcb_f831_4e04_acc4_d6d961630419
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110005#_13900750_2a23_4f1a_ab62_e0b54c40fe64
is: P49914
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:10588
initial amount: NaN
name: MTHFS
initial concentration: NaN

metaM 34hpp c
initial concentration: 1.0
is: CHEBI:36242
constant: false
name: 3-(4-hydroxyphenyl)pyruvate
boundary condition: false
is: SBO:0000247
is: HMDB00707
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179

http://identifiers.org/biomodels.db/MODEL1310110005#_e16a9d95_3839_4acd_b3f2_509e4063d1af
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:159963
boundary condition: true
name: SLC5A12
is: Q1EHB4
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_93ffcb34_c64c_4799_86ea_d8443981fc0f
is encoded by: hsa:3939
is: P00338
is: SBO:0000252
has only substance units: false
name: LDHA
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

metaR ADA
name: Adenosine deaminase
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
is described by: ECO:0000269
reversible: false
fast: false
is: SBO:0000176
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.5.4.4

http://identifiers.org/biomodels.db/MODEL1310110005#_b6d1a505_8d17_4fcb_b7d8_32e9e59fc17f
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AA854479
name: _AA854479_1_m

metaR RE1447M
reversible: true
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
name: RE1447
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.41
is described by: ECO:0000000
type: Reaction
fast: false
modifier: MODEL1310110005#
is: SBO:0000176

metaR Htx
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110005#
name: H transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000

metaM 13dampp c
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00002
type: Species
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
boundary condition: false
is: CHEBI:57484
initial concentration: 1.0
name: trimethylenediaminium
initial amount: NaN

W3 CDTF: Thu Aug 30 14:48:47 BST 2012

metaM dnad c
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB01179
is: C00857
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
name: Deamino-NAD+
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:18304
constant: false

metaM xol7aone m
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: HMDB01993
name: 7alpha-hydroxycholest-4-en-3-one
is: CHEBI:17899
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_f2a5cee1_62ff_4087_8c5f_1bf750c90d7b
name: ALDH1A3
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
is: P47895
is encoded by: hsa:220
boundary condition: true
has only substance units: false

metaR URAt
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
reactant: MODEL1310110005#
type: Reaction
modifier: MODEL1310110005#
is described by: ECO:0000269
name: uracil transport via facilated diffusion
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_3c149356_9500_4e64_a2cd_b0bec4bd402e
initial amount: NaN
is: P19961
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:280
type: Species
name: AMY2B
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_79972851_9b3d_4dd9_96fe_83e21b8df754
initial amount: NaN
is: P40926
name: MDH2
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:4191
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_b7a2cbb6_40de_481e_9166_1468f75d8f87
initial amount: NaN
is encoded by: hsa:8372
initial concentration: NaN
name: HYAL3
constant: false
is: SBO:0000252
is: O43820
type: Species
has only substance units: false
boundary condition: true

metaR 2DR1PP
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reversible: false
product: MODEL1310110005#
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD

metaM ncam c
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
name: Nicotinamide
type: Species
has only substance units: false
initial concentration: 1.0
is: C00153
notes: FORMULA: C6H6N2O CHARGE: 0
is: HMDB01406
is: CHEBI:0

metaR MGCHrm
notes: GENE_ASSOCIATION: (549.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.18 Confidence Level: 4 AUTHORS: PMID:12434311,PMID:3082934 NOTES:MM
name: methylglutaconyl-CoA hydratase (reversible), mitochondrial
reactant: MODEL1310110005#
fast: false
reversible: true
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/4.2.1.18
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110005#

metaR RE3005M
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3005
modifier: MODEL1310110005#
fast: false
product: MODEL1310110005#
reversible: true
is: SBO:0000176
reactant: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107

metaM lald D c
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
boundary condition: false
name: (R)-lactaldehyde
constant: false
initial concentration: 1.0
is: CHEBI:17167
is: HMDB06458
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM citr L e
is: SBO:0000247
is: CHEBI:16349
constant: false
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: HMDB00904
boundary condition: false
type: Species
name: citr_L[e]
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_2c70b4f8_7002_4bfd_a06d_9014637e073a
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: _AA614647_1_c
constant: false
type: Species
has only substance units: false
is encoded by: hsa:AA614647

metaR CYTK10n
kinetic law: MODEL1310110005#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110005#
reversible: true
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
name: cytidylate kinase (CMP,dGTP),nuclear
type: Reaction
product: MODEL1310110005#
is: SBO:0000176

W3 CDTF: Thu Aug 30 14:48:47 BST 2012

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaM 34hpp e
constant: false
has only substance units: false
is: CHEBI:36242
initial concentration: 1.0
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
is: SBO:0000247
name: 3-(4-hydroxyphenyl)pyruvate
boundary condition: false
is: HMDB00707
initial amount: NaN
type: Species

metaM 2mop c
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB01172
is: CHEBI:57700
initial concentration: 1.0
name: 2-methyl-3-oxopropanoate
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349

metaM pro L e
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
boundary condition: false
name: L-proline
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: HMDB00162

metaR 3SALATAi
kinetic law: MODEL1310110005#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000304
is: SBO:0000176
fast: false
product: MODEL1310110005#
modifier: MODEL1310110005#
reactant: MODEL1310110005#
name: 3-sulfino-alanine transaminase (irreversible)
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain

http://identifiers.org/biomodels.db/MODEL1310110005#_31f1c250_3f23_4e9b_9454_8ef91c9d280e
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000297
boundary condition: true
is encoded by: hsa:23428
has part: Q86U05
type: Species
name: SLC7A8:SLC3A2

metaM srtn c
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
boundary condition: false
is: HMDB00259
name: serotonin(1+)
is: CHEBI:350546

metaR RE3626M
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
name: RE3626
reactant: MODEL1310110005#
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
modifier: MODEL1310110005#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110005#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_5a811b02_6ab8_4761_8fd8_cda657666678
constant: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:53354
is: Q8TE04
name: PANK1
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM mercppyr c
is: HMDB01368
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:57678
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
has only substance units: false
boundary condition: false
name: 3-mercaptopyruvate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_bc8c516f_fd14_433a_90ed_c1679792d2ca
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: Q6PII5
constant: false
is: SBO:0000252
name: HAGHL
is encoded by: hsa:84264
initial concentration: NaN

W3 CDTF: Thu Aug 30 14:48:47 BST 2012

metaR r0426
type: Reaction
modifier: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.5.1.34
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
product: MODEL1310110005#
is: SBO:0000176
reversible: true

metaR CYTK8
name: cytidylate kinase (CMP,dATP)
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reactant: MODEL1310110005#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
product: MODEL1310110005#
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110005#_09070cc8_e8a0_4c2e_b779_3b047bc16488
constant: false
type: Species
name: DHCR24
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1718
is: Q15392

metaM 2mop m
initial amount: NaN
is: CHEBI:57700
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
is: HMDB01172
name: 2-methyl-3-oxopropanoate
type: Species
initial concentration: 1.0

metaM 2mb2coa m
is: HMDB02054
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:57337
type: Species
initial amount: NaN
name: 2-methylcrotonoyl-CoA(4-)
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
constant: false
boundary condition: false

metaM ala B e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
is: CHEBI:16958
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00056
constant: false
type: Species
initial amount: NaN

metaM pristcoa c
is: CHEBI:51341
initial amount: NaN
has only substance units: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
name: pristanoyl coa

http://identifiers.org/biomodels.db/MODEL1310110005#_a0b8dc46_6e9d_455e_af65_9aab9d413f73
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: _AI539321_1_c
initial amount: NaN
constant: false
is encoded by: hsa:AI539321

metaM succ x
is: CHEBI:30031
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: C00042
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: Succinate
is: HMDB00254
initial concentration: 1.0
boundary condition: false

metaM cyan e
name: hydrogen cyanide
has only substance units: false
is: HMDB02084
is: CHEBI:18407
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
boundary condition: false
initial concentration: 1.0

metaR MAN6PI
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/5.3.1.8
modifier: MODEL1310110005#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110005#
product: MODEL1310110005#
name: mannose-6-phosphate isomerase
is: SBO:0000176
fast: false
reversible: true

metaR r1365
fast: false
product: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
name: Vesicular transport
reversible: false
kinetic law: MODEL1310110005#

metaR LNLNCAt
name: fatty acid transport via diffusion
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#

metaR HISSNAT5tc
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaM CE2705 n
type: Species
boundary condition: false
is: CHEBI:15374
name: quinonoid dihydrobiopterin
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: HMDB02281
initial amount: NaN
has only substance units: false

metaR CYTK9
reversible: true
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110005#
name: cytidylate kinase (CMP,dCTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

metaR r1551
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
reversible: true

metaR ME2
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
reversible: false
name: malic enzyme (NADP)
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.40
notes: GENE_ASSOCIATION: (4199.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:
fast: false
product: MODEL1310110005#
is: SBO:0000176

metaR FAOXC80
reversible: false
reactant: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
name: Beta oxidation of med/long chain fatty acid
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211

metaM arach e
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
initial concentration: 1.0
name: arachidate
is: CHEBI:32360
is: HMDB02212
boundary condition: false

metaR r1671
reactant: MODEL1310110005#
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_faf16850_a4aa_4e36_8e93_0ad6fc09f052
initial concentration: NaN
name: NDUFA1
is: Q6IBB5
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:4694
is: SBO:0000252
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_0b1b7f82_88a4_42f9_b6fa_14d8d955eb7f
type: Species
initial amount: NaN
name: SDHA
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: P31040
is encoded by: hsa:6389

metaM ctp m
type: Species
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
constant: false
initial concentration: 1.0
is: HMDB00082
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM btn e
has only substance units: false
is: CHEBI:3420
notes: FORMULA: C10H15N2O3S CHARGE: -1
boundary condition: false
is: C00120
initial concentration: 1.0
is: HMDB00030
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
name: Biotin

metaR r1364
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000185
name: Vesicular transport
reversible: false
type: Reaction
reactant: MODEL1310110005#
fast: false
is described by: ECO:0000000

metaR COAtl
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
fast: false
reactant: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
name: CoA transport in lysosome via diffusion
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185

metaM h2o2 m
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: C00027
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: Hydrogen peroxide
is: CHEBI:16240
is: HMDB03125
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_f1297ed4_aac2_427f_ab59_4684b12b2159
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q59EA4
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5337
type: Species
name: PLD1

metaR r1552
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction

metaM 2mpdhl m
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
is: CHEBI:17577
has only substance units: false
is: SBO:0000247
name: S-(2-Methylpropanoyl)-dihydrolipoamide
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false

metaR r0642
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110005#
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
product: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110005#_a066f1c9_3ea3_47dc_a566_dab5f91de1b2
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: SOD2
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:6648
is: P04179

http://identifiers.org/biomodels.db/MODEL1310110005#_4c843ea1_fbe3_4e96_9862_fc5b50cf034e
constant: false
initial amount: NaN
is encoded by: hsa:1738
boundary condition: true
is: P09622
type: Species
name: DLD
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaM ps hs e
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
name: phosphatidylserine
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:18303
has only substance units: false

metaR FRDPtcr
product: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
reversible: true
fast: false
is described by: ECO:0000134

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_47c24938_9a86_4bdc_a64a_c0430f7c4996
is encoded by: hsa:159
name: ADSS
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: P30520
is: SBO:0000252

metaR COAtm
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
is described by: ECO:0000269
product: MODEL1310110005#
name: CoA transporter
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#

metaM ctp n
constant: false
is: HMDB00082
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
has only substance units: false
initial amount: NaN
is: CHEBI:37563
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
name: CTP(4-)

metaM cyan c
is: HMDB02084
is: CHEBI:18407
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
boundary condition: false
type: Species
initial concentration: 1.0
name: hydrogen cyanide
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false

metaM h2o2 n
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
boundary condition: false
is: CHEBI:16240
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: hydrogen peroxide
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_5919be81_5fbf_4742_89a3_ab539e2f5bf7
type: Species
constant: false
boundary condition: true
initial amount: NaN
is: Q8TCD5
name: NT5C
is encoded by: hsa:30833
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR FALDH
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.1
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
kinetic law: MODEL1310110005#
reversible: true
name: formaldehyde dehydrogenase
modifier: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000176
type: Reaction

metaR TCHOLAt2
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6554.1) or (6555.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12851823,PMID:7592981,PMID:8132774,PMID:9109432 NOTES:electrogenic uptake NJ
kinetic law: MODEL1310110005#
type: Reaction
reversible: false
name: taurocholate transport via sodium cotransport
modifier: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000269
product: MODEL1310110005#

metaR r1553
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110005#

metaR AKR1D
fast: false
reactant: MODEL1310110005#
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
type: Reaction
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
is: SBO:0000176
kinetic law: MODEL1310110005#
product: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.3

metaR r0641
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
kinetic law: MODEL1310110005#
reversible: true
is: SBO:0000176
product: MODEL1310110005#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.4

metaM arach c
constant: false
boundary condition: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
initial concentration: 1.0
has only substance units: false
is: HMDB02212
initial amount: NaN
is: CHEBI:32360
is: SBO:0000247
name: arachidate
type: Species

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_3fe9aa44_c180_483a_ac51_31ecdf00e08a
initial amount: NaN
name: FOLR1
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:2348
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_7c923d9d_76a8_4b4c_bfe6_3c565dd4f582
is encoded by: hsa:6566
type: Species
constant: false
name: SLC16A1
is: B4DKS0
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR DCMPDA
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
reversible: true
reactant: MODEL1310110005#
type: Reaction
modifier: MODEL1310110005#
is described by: ECO:0000254
product: MODEL1310110005#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.5.4.12
name: dCMP deaminase

metaM btn c
notes: FORMULA: C10H15N2O3S CHARGE: -1
boundary condition: false
is: CHEBI:3420
initial concentration: 1.0
is: C00120
is: HMDB00030
type: Species
name: Biotin
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false

metaR COAtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110005#
name: coenzyme A transport, nuclear
fast: false
is: SBO:0000185
kinetic law: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_4f2eca29_4ad3_48eb_8423_0670a1a73bf6
name: SLC1A7
is encoded by: hsa:6512
type: Species
is: O00341
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

metaM i e
initial amount: NaN
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:16382
name: iodide
constant: false
boundary condition: false
is: HMDB12238

metaR BILIRUBt2
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
is: SBO:0000185
name: bilirubin transport via bicarbonate countertransport
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110005#
reversible: true

metaR FAOXC204
product: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110005#
fast: false
type: Reaction
modifier: MODEL1310110005#
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
kinetic law: MODEL1310110005#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR UPPN
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.5.1.6
type: Reaction
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:10542323,PMID:12450676 NOTES:SAB balanced
fast: false
kinetic law: MODEL1310110005#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110005#
name: b-ureidopropionase
modifier: MODEL1310110005#
reversible: false

metaR r0644
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110005#
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
product: MODEL1310110005#
fast: false
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR ARACHDtr
reactant: MODEL1310110005#
name: intracellular transport
fast: false
reversible: true
product: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is described by: ECO:0000000

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaR r1554
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110005#

metaM maltpt e
initial concentration: 1.0
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
boundary condition: false
initial amount: NaN
is: HMDB01296
has only substance units: false
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5141
is: C02052
constant: false
name: maltopentaose

metaR FAOXC1811603m
kinetic law: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
name: Beta oxidation fatty acid
reversible: false
modifier: MODEL1310110005#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110005#_a2272b46_a024_4c8e_a72e_9c2243d1e78d
type: Species
has only substance units: false
constant: false
is encoded by: hsa:AI697028
name: _AI697028_1_e
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM c4crn e
name: butyryl carnitine
is: http://identifiers.org/pubchem.compound/213144
initial amount: NaN
boundary condition: false
is: HMDB02013
type: Species
constant: false
notes: FORMULA: C11H21NO4 CHARGE: 0
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C02862

http://identifiers.org/biomodels.db/MODEL1310110005#_71ce9b87_f52d_432e_8d6b_29400b8b2859
boundary condition: true
name: SLC25A6
initial amount: NaN
constant: false
is encoded by: hsa:293
initial concentration: NaN
type: Species
is: Q6I9V5
has only substance units: false
is: SBO:0000252

metaR DUTPDPn
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.6.1.23
is: SBO:0000176
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
reversible: false
fast: false
product: MODEL1310110005#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110005#
name: dUTP diphosphatase, nuclear
reactant: MODEL1310110005#

metaM pgp hs c
has only substance units: false
initial amount: NaN
is: HMDB01335
type: Species
boundary condition: false
name: phosphatidyl glycerol phosphate
is: CHEBI:57403
notes: FORMULA: C6H11O9P2FULLRCO2FULLR2CO2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC02095
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR ADK3m
is described by: ECO:0000269
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.4.10
reversible: true
reactant: MODEL1310110005#
name: adentylate kinase (GTP)
product: MODEL1310110005#

metaR TRPt
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
is: SBO:0000185
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110005#
type: Reaction
name: L-tryptophan transport
kinetic law: MODEL1310110005#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110005#_6fb77461_dbda_4b32_8e1a_1434d3556bef
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:587
initial concentration: NaN
is: O15382
constant: false
has only substance units: false
name: BCAT2
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_189cf4d7_4a44_4f1c_81b3_b341f9002bfd
name: AK5
is encoded by: hsa:26289
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: Q9Y6K8
boundary condition: true
is: SBO:0000252
constant: false

metaM glu L e
name: L-glutamate(1-)
has only substance units: false
is: CHEBI:29985
is: HMDB00148
initial concentration: 1.0
constant: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false

metaR CYTK5n
is: SBO:0000176
reactant: MODEL1310110005#
fast: false
name: cytidylate kinase (CMP),nuclear
modifier: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110005#
reversible: true
is described by: ECO:0000269
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:

metaR RE0452M
product: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
kinetic law: MODEL1310110005#
name: RE0452
reversible: true

metaR GLYCTO1p
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
name: Glycolate oxidase, peroxisome
modifier: MODEL1310110005#
is described by: ECO:0000269
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.3.15
product: MODEL1310110005#

metaM ps hs m
is: CHEBI:18303
name: ps_hs[m]
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false

metaR COAtp
reactant: MODEL1310110005#
name: coenzyme A transport, peroxisomal
fast: false
is: SBO:0000185
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reversible: true

metaM tchola c
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
is: SBO:0000247
name: taurocholic acid
is: HMDB00036
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:36257

metaR FAOXC140
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
product: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110005#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110005#
fast: false

metaM dtdp n
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
has only substance units: false
boundary condition: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB01274
constant: false

metaR r2526
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110005#
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110005#
reactant: MODEL1310110005#

metaR PROSTGD2t
type: Reaction
reactant: MODEL1310110005#
is described by: ECO:0000269
reversible: true
product: MODEL1310110005#
name: prostaglandin transport via bicarbonate countertransport
is: SBO:0000185
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110005#
fast: false

metaR EX pectindchac LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-deoxycholic acid complex
type: Reaction

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaM g3p c
boundary condition: false
is: http://identifiers.org/pubchem.compound/3930
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
initial concentration: 1.0
is: C00661
is: HMDB01112
name: Glyceraldehyde 3-phosphate
has only substance units: false
constant: false
type: Species
is: CHEBI:58027
initial amount: NaN
is: SBO:0000247

metaR r1556
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110005#
type: Reaction
product: MODEL1310110005#
kinetic law: MODEL1310110005#

metaM c4crn c
type: Species
is: http://identifiers.org/pubchem.compound/213144
constant: false
name: butyryl carnitine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB02013
boundary condition: false
notes: FORMULA: C11H21NO4 CHARGE: 0
is: C02862
has only substance units: false

metaM pro L m
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00162
constant: false
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: CHEBI:17203
is: SBO:0000247
name: L-proline
initial concentration: 1.0

metaM HC02187 c
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:28774
initial amount: NaN
name: reverse-triiodthyronine
boundary condition: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)

http://identifiers.org/biomodels.db/MODEL1310110005#_e4a2e006_75fb_4762_9b8d_5ed2af17ced4
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
name: _PRO1933_1_m
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:PRO1933

http://identifiers.org/biomodels.db/MODEL1310110005#_f0d702fc_fa99_44c7_b665_8585c19f5ea6
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q16698
constant: false
initial amount: NaN
boundary condition: true
name: DECR1
is encoded by: hsa:1666

metaM dtdp m
type: Species
is: CHEBI:58369
is: SBO:0000247
boundary condition: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
initial amount: NaN
has only substance units: false
is: C00363
initial concentration: 1.0
is: HMDB01274
name: dTDP

metaM ala B c
boundary condition: false
has only substance units: false
is: HMDB00056
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
constant: false
type: Species
is: SBO:0000247
is: CHEBI:16958
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_4d74478e_2d92_43c5_8b74_734891bccebe
initial concentration: NaN
boundary condition: true
is encoded by: hsa:728441
constant: false
is: SBO:0000252
initial amount: NaN
name: GGT2
type: Species
has only substance units: false

metaM xol7aone r
initial amount: NaN
name: 7alpha-hydroxycholest-4-en-3-one
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:17899
is: HMDB01993
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial concentration: 1.0

metaM icit c
is: HMDB00193
constant: false
is: C00311
is: CHEBI:16087
initial amount: NaN
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial concentration: 1.0
is: SBO:0000247
type: Species
name: Isocitrate
boundary condition: false
has only substance units: false

metaM ttdca e
has only substance units: false
is: CHEBI:30807
name: tetradecanoate (n-C14:0)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00806
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
is: C06424
constant: false
type: Species

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

metaM gly x
initial concentration: 1.0
constant: false
is: CHEBI:15428
name: glycine
is: SBO:0000247
is: HMDB00123
boundary condition: false
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
initial amount: NaN
type: Species
has only substance units: false

metaM 3mox4hoxm c
boundary condition: false
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
constant: false
initial amount: NaN
is: HMDB00291
is: SBO:0000247
is: CHEBI:27622
type: Species
initial concentration: 1.0
has only substance units: false
name: 3-Methoxy-4-hydroxymandelate

metaR r1557
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
is: SBO:0000185
reactant: MODEL1310110005#
type: Reaction

metaR ICDHyrm
name: Isocitrate dehydrogenase (NADP+)
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
product: MODEL1310110005#
is described by: ECO:0000269
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
modifier: MODEL1310110005#
is: SBO:0000176

metaR COAtr
product: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
name: COA transporter, endoplasmic reticulum
reversible: true
kinetic law: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
fast: false

metaM HC02214 c
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:28852
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
has only substance units: false
name: prostaglandin-f1alpha

metaM xol25oh r
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:42977
is: HMDB06247
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
name: 25-hydroxycholesterol

http://identifiers.org/biomodels.db/MODEL1310110005#_3d02bab5_10c8_4a9a_ba36_23f43b352a26
initial concentration: NaN
constant: false
is: Q4J699
is: SBO:0000252
is encoded by: hsa:491
initial amount: NaN
has only substance units: false
name: ATP2B2
type: Species
boundary condition: true

metaM msa m
boundary condition: false
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
has only substance units: false
is: SBO:0000247
is: CHEBI:33190
initial concentration: 1.0
name: 3-oxopropanoate
is: HMDB11111
initial amount: NaN
type: Species

metaR r2040
product: MODEL1310110005#
modifier: MODEL1310110005#
reversible: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM tchola e
has only substance units: false
is: SBO:0000247
notes: FORMULA: C26H45NO7S CHARGE: 0
is: HMDB00036
initial amount: NaN
type: Species
name: taurocholic acid
boundary condition: false
initial concentration: 1.0
constant: false

metaR r1906
fast: false
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110005#
name: Y+LAT2 Utilized transport
reversible: false
reactant: MODEL1310110005#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_d1ec111a_4eba_43a6_a65b_a61b62dbeb29
initial amount: NaN
is: P04075
type: Species
is encoded by: hsa:226
initial concentration: NaN
name: ALDOA
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_8a48314b_b7a1_44b7_a0e5_7dd8a3f7fd41
constant: false
has only substance units: false
is encoded by: hsa:4513
is: Q7GXZ8
name: COX2
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaM din c
is: CHEBI:28997
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
initial amount: NaN
is: C05512
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00071
name: Deoxyinosine

metaM dgsn c
is: C00330
initial amount: NaN
type: Species
is: CHEBI:17172
boundary condition: false
name: Deoxyguanosine
constant: false
is: HMDB00085
initial concentration: 1.0
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: SBO:0000247
has only substance units: false

metaR 4HGLSDm
modifier: MODEL1310110005#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: true
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
type: Reaction
is described by: ECO:0000212

metaM ctp e
boundary condition: false
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00082
is: SBO:0000247
name: CTP(4-)
initial amount: NaN

metaM HC00591 m
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:16769
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
is: SBO:0000247
type: Species
name: 2-oxoglutaramate

metaR DADAe
name: Deoxyadenosine deaminase, extracellular
is: SBO:0000176
type: Reaction
product: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000269
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
is version of: http://identifiers.org/ec-code/3.5.4.4
reactant: MODEL1310110005#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110005#_b4913c6c_0721_4e18_be0f_5403fd2f7e18
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:9377
is: P20674
boundary condition: true
is: SBO:0000252
type: Species
name: COX5A
initial concentration: NaN

metaM ascb L e
has only substance units: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial amount: NaN
is: HMDB00044
boundary condition: false
is: SBO:0000247
type: Species
constant: false
name: L-ascorbate
is: CHEBI:38290
initial concentration: 1.0

metaR r0393
fast: false
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
modifier: MODEL1310110005#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.1.74
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:

metaR r0280
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
modifier: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000176
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
product: MODEL1310110005#

metaM ditp n
is: CHEBI:61382
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
name: dITP(4-)
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: HMDB03537
type: Species
initial amount: NaN
has only substance units: false

metaM HC02187 e
initial amount: NaN
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
has only substance units: false
is: CHEBI:28774
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
name: reverse-triiodthyronine

http://identifiers.org/biomodels.db/MODEL1310110005#_e696c959_f76a_4d06_9061_4ece246b46d6
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:248
initial concentration: NaN
name: ALPI
initial amount: NaN
is: P09923
has only substance units: false
type: Species

metaR ASNtN1
type: Reaction
is: SBO:0000185
product: MODEL1310110005#
name: Asparagine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
fast: false
reactant: MODEL1310110005#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#

metaM ala B m
name: beta-alanine
is: HMDB00056
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: CHEBI:16958

http://identifiers.org/biomodels.db/MODEL1310110005#_0da8a578_10e5_4cd5_971b_e04df13a0fbf
boundary condition: true
has only substance units: false
name: ENTPD3
initial amount: NaN
is encoded by: hsa:956
is: O75355
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species

metaM din e
has only substance units: false
is: C05512
is: CHEBI:28997
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
name: Deoxyinosine
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
constant: false
is: HMDB00071

metaR r0392
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
reactant: MODEL1310110005#
type: Reaction
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_9a04c865_8568_40d1_af65_7639d328c186
is: Q13057
constant: false
has only substance units: false
is encoded by: hsa:80347
initial concentration: NaN
name: COASY
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR RE1522M
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
reversible: true
name: RE1522
reactant: MODEL1310110005#
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110005#_d8319aa9_8518_4e74_b6ad_2b7111f2503a
name: NDUFB7
initial amount: NaN
initial concentration: NaN
is: P17568
type: Species
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4713

metaM Lpipecol x
is: HMDB00716
name: L-pipecolic acid
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:30913
is: SBO:0000247
initial amount: NaN
constant: false

metaM ascb L c
is: CHEBI:38290
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
type: Species
initial amount: NaN
has only substance units: false
constant: false
name: L-ascorbate
initial concentration: 1.0
is: HMDB00044

metaM oh1 c
initial amount: NaN
has only substance units: false
boundary condition: false
is: C01328
name: hydroxide ion
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01039
notes: FORMULA: HO CHARGE: -1

metaR r0921
fast: false
type: Reaction
reactant: MODEL1310110005#
name: Postulated transport reaction
kinetic law: MODEL1310110005#
product: MODEL1310110005#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12006583,PMID:1260500,PMID:12838422,PMID:14747464,PMID:16595656,PMID:168203,PMID:17187757,PMID:17279066,PMID:3728675,PMID:6778226,PMID:7419607,PMID:7479738,PMID:8438778 NOTES:
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_58c08a6c_9d43_4001_a67b_45b336f3e91c
is: F8WDN9
type: Species
name: PPA2
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:27068
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_b42739fc_b278_40eb_92d5_cd01b27d0377
is encoded by: hsa:4351
name: MPI
type: Species
constant: false
initial amount: NaN
is: P34949
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM lcts e
name: Lactose
initial concentration: 1.0
is: HMDB00186
initial amount: NaN
is: C00243
type: Species
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:17716
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_fa2b5986_a885_4943_bded_6b88be15021e
boundary condition: true
name: SLC4A10
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: B7Z1R0
is encoded by: hsa:57282
initial amount: NaN

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

metaM fald c
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
name: formaldehyde
constant: false
is: HMDB01426
is: CHEBI:16842
initial amount: NaN
initial concentration: 1.0

metaM dgsn e
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17172
is: SBO:0000247
constant: false
type: Species
has only substance units: false
boundary condition: false
name: Deoxyguanosine
is: C00330
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: HMDB00085

metaM lnlnca r
is: SBO:0000247
is: CHEBI:32387
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
constant: false
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB01388
name: alpha-linolenate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_40df79c4_078e_4475_8e67_eec1ec95569e
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P40879
is encoded by: hsa:1811
constant: false
initial concentration: NaN
name: SLC26A3

metaR PSP L
type: Reaction
is described by: ECO:0000269
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.3
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
name: phosphoserine phosphatase (L-serine)
modifier: MODEL1310110005#
is: SBO:0000176

metaR r2031
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110005#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110005#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
fast: false
product: MODEL1310110005#
reversible: false

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR EX mag hs LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Monoacylglycerol 2 (homo sapiens) exchange
type: Reaction

metaR r0638
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.1.2
reversible: true
product: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_ec505026_bdd4_42be_b37e_a87875a3d8fc
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is: P15121
initial amount: NaN
boundary condition: true
is encoded by: hsa:231
name: AKR1B1

http://identifiers.org/biomodels.db/MODEL1310110005#_3f4e106d_a9b3_4cf6_a65f_0c1d9ef8b8e8
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: E5KNH5
is encoded by: hsa:4723
constant: false
initial amount: NaN
has only substance units: false
name: NDUFV1
type: Species

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaR 3HKYNAKGAT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.64
kinetic law: MODEL1310110005#
fast: false
reversible: false
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.6.1.7
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
type: Reaction
modifier: MODEL1310110005#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_62c1587e_de32_436d_8225_def5cfdcbe5c
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: Q53YB7
constant: false
is encoded by: hsa:1329
name: COX5B
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110005#_ef6d4868_7c0d_4fff_b0c5_79a396d8e52c
is: Q969K7
boundary condition: true
is encoded by: hsa:113452
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: TMEM54
initial concentration: NaN

metaR SPODMx
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
fast: false
reversible: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110005#
name: superoxide dismutase, peroxisome
is version of: http://identifiers.org/ec-code/1.15.1.1
product: MODEL1310110005#

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_77087459_836b_4812_8d36_a48050f9422d
is encoded by: hsa:3030
has part: P55084
boundary condition: true
constant: false
has part: E9KL44
initial amount: NaN
type: Species
is: SBO:0000297
is encoded by: hsa:3032
initial concentration: NaN
has only substance units: false
name: HADHA:HADHB

http://identifiers.org/biomodels.db/MODEL1310110005#_de24aeac_e94d_4a09_b201_d4be7602e61f
name: AKR1C4
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is: P17516
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1109
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_9a08821b_44b1_4dce_8367_0f2bd402e7ab
constant: false
is: SBO:0000252
is encoded by: hsa:29920
is: Q96C36
name: PYCR2
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_fdb7a3e4_865d_496c_94ea_399d4f2ef801
is: Q8N695
name: SLC5A8
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:160728
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR EX 23cump LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2',3'-cyclic UMP(1-) exchange
type: Reaction

metaR r0394
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110005#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
is described by: ECO:0000000
product: MODEL1310110005#
reactant: MODEL1310110005#

metaM CE2705 c
type: Species
initial concentration: 1.0
name: quinonoid dihydrobiopterin
is: CHEBI:36781
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
constant: false
initial amount: NaN

metaR PSFLIPm
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
name: phosphatidylserine flippase
reversible: false
reactant: MODEL1310110005#
product: MODEL1310110005#
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/3.6.3.1
kinetic law: MODEL1310110005#
is described by: ECO:0000269
type: Reaction

metaM nadh r
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: SBO:0000247
is: HMDB01487
name: NADH(2-)
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:57945

metaR r2376
type: Reaction
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
reactant: MODEL1310110005#
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true

metaR PYNP2r
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110005#
name: pyrimidine-nucleoside phosphorylase (uracil)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.3
notes: GENE_ASSOCIATION: (7378.2) or (151531.1) or (7378.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.2 Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12084455,PMID:12849978,PMID:7488099 NOTES:JLR- added reversible form of PYNP2
is described by: ECO:0000269
product: MODEL1310110005#
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaM HC02203 e
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
constant: false
type: Species
is: CHEBI:27820
name: prostaglandin-a2

metaR RE3524R
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reversible: true
fast: false
product: MODEL1310110005#
name: RE3524

http://identifiers.org/biomodels.db/MODEL1310110005#_73a633a3_1091_4c8a_89f1_f13b9053b2ef
constant: false
is: O43488
initial concentration: NaN
type: Species
name: AKR7A2
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:8574

metaM xol7ah c
initial amount: NaN
is: CHEBI:2290
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
is: SBO:0000247
type: Species
is: HMDB06892
has only substance units: false
boundary condition: false
constant: false
name: 7alpha-hydroxy-5beta-cholestan-3-one
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_bf9685ad_9ff1_4d82_9881_5e092312118d
initial amount: NaN
has only substance units: false
constant: false
is: Q9NRF8
type: Species
is: SBO:0000252
name: CTPS2
boundary condition: true
is encoded by: hsa:56474
initial concentration: NaN

metaR r0639
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110005#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110005#
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16

metaR r2034
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110005#
reversible: false

metaR r1902
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110005#
modifier: MODEL1310110005#
reactant: MODEL1310110005#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
name: Y+LAT2 Utilized transport
reversible: false

metaM pectindchac e
name: pectin-deoxycholic acid complex
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB03402
notes: FORMULA: C2559H3549O2539 CHARGE: -1
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_2ba2b339_f54a_4951_9fc2_cb2c7269e1eb
is: SBO:0000252
type: Species
is: Q549M5
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: NDUFC2
is encoded by: hsa:4718

http://identifiers.org/biomodels.db/MODEL1310110005#_a83e2c8a_97d4_4dfd_b811_015c05ec6aa1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: NDUFC1
is encoded by: hsa:4717
is: O43677
type: Species
constant: false
has only substance units: false

metaM mercplaccys c
constant: false
is: SBO:0000247
boundary condition: false
name: 3-mercaptolactate-cysteine disulfide
is: HMDB06512
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
initial amount: NaN

metaM 3hmp m
constant: false
initial amount: NaN
is: CHEBI:11805
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
boundary condition: false
is: SBO:0000247
is: HMDB00023
name: 3-hydroxy-2-methylpropanoate
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_3a12d081_e4aa_42c3_9446_0a25041164cb
constant: false
is: P32189
is encoded by: hsa:2710
has only substance units: false
initial concentration: NaN
boundary condition: true
name: GK
initial amount: NaN
is: SBO:0000252
type: Species

metaR RBTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false
kinetic law: MODEL1310110005#
name: ribitol transport via passive diffusion
type: Reaction
reactant: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000185
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_8676c1fe_ab6a_492f_bf63_224da42ad656
name: CHKB
boundary condition: true
type: Species
is: A0PJM6
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1120
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_fb6c1438_c0d1_4065_87de_43c69e4087cc
has only substance units: false
type: Species
is: P23786
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:1376
constant: false
initial concentration: NaN
name: CPT2

metaM 2hb e
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
type: Species
name: 2-Hydroxybutyrate
initial concentration: 1.0
is: HMDB00008
has only substance units: false
is: CHEBI:1148
constant: false

metaM icit m
is: C00311
initial concentration: 1.0
is: HMDB00193
initial amount: NaN
type: Species
boundary condition: false
name: Isocitrate
is: SBO:0000247
constant: false
is: CHEBI:16087
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
has only substance units: false

metaR r2377
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110005#
product: MODEL1310110005#

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaM i c
has only substance units: false
initial concentration: 1.0
is: HMDB12238
type: Species
name: iodide
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:16382
is: SBO:0000247

metaM leu L m
initial amount: NaN
boundary condition: false
is: CHEBI:15603
name: L-leucine
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
constant: false
is: HMDB00687

metaM ps hs c
name: ps_hs[c]
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:18303
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR r0068
kinetic law: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (134526.1) SUBSYSTEM: Unassigned EC Number: 6.2.1.1 Confidence Level: 0 AUTHORS: PMID:10843999,PMID:14086739,PMID:238571,PMID:2901103 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.1
is: SBO:0000176
name: Acetyl adenylate:CoA ligase (AMP-forming) Pyruvate metabolism EC:6.2.1.1
modifier: MODEL1310110005#
product: MODEL1310110005#
reactant: MODEL1310110005#
fast: false

metaR AHCYSte
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of S-adenosyl-L-homocysteine
is described by: ECO:0000134
product: MODEL1310110005#
fast: false
is: SBO:0000185
type: Reaction
reversible: true

MODEL1310110005#
species: metaM crn c
species: metaM hLkynr c
species: metaM retinol cis 11 c
species: metaM o2s c
species: metaM HC00342 m
species: metaM CE2705 n
species: metaM HC01231 c
species: metaM dttp m
species: metaM malthx e
species: metaM dcacoa m
species: metaM xol7aone c
species: metaM 3otdcoa m
species: metaM his L c
species: metaM leuktrD4 e
species: metaM pyr c
species: metaM gtp m
species: metaM mal L e
species: metaM ca2 c
species: metaM 3sala c
species: metaM dhap m
species: metaM CE2418 m
species: metaM cdp c
species: metaM q10 m
species: metaM HC01405 m
species: metaM atp m
species: metaM hxan e
stoichiometry: 8.0
species: metaM C05279 m
species: metaM CE0693 m
species: metaM akg e
species: metaM ru5p D c
species: metaM cyan c
species: metaM retinal cis 13 r
species: metaM 2dr5p c
stoichiometry: 7.92
species: metaM ppi e
species: metaM dhf m
species: metaM succ c
species: metaM ala B e
species: metaM lac L e
species: metaM cmpacna n
stoichiometry: 0.325996
stoichiometry: 7.0
species: metaM 3pg c
species: metaM HC02205 c
species: metaM glyc R m
species: metaM ump c
species: metaM acgam l
species: metaM HC02214 e
species: metaM arachcrn c
species: metaM datp c
species: metaM adn e
species: metaM nadh m
species: metaM HC02208 e
species: metaM guln c
species: metaM lnlnca r
species: metaM dha e
species: metaM adp m
species: metaM b2coa m
species: metaM for e
stoichiometry: 0.545544
type: SpeciesReference
species: metaM gly c
stoichiometry: 0.592114
has only substance units: false
species: metaM cholp c
species: metaM CE2417 m
species: metaM maltpt e
species: metaM dgdp n
species: metaM tdcoa c
species: metaM CE5121 m
species: metaM 3ump e
species: metaM spmd e
species: metaM gthox c
multipler: 1.0
species: metaM dgmp c
species: metaM phe L m
species: metaM arachcrn m
species: metaM HC01401 m
species: metaM leuktrA4 c

metaR TALA
type: Reaction
modifier: MODEL1310110005#
name: transaldolase
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.2.1.2
is: SBO:0000176
reactant: MODEL1310110005#
reversible: true

metaR r2378
reversible: true
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction

metaR KHK2
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110005#
fast: false
type: Reaction
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 2.7.1.3 Confidence Level: 4 AUTHORS: PMID:2996495,PMID:6284103,PMID:6298387 NOTES:NCD
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.7.1.3
name: ketohexokinase (D-xylulose)
product: MODEL1310110005#
is: SBO:0000176

metaR O2ter
name: O2 transport, endoplasmic reticulum
reactant: MODEL1310110005#
fast: false
product: MODEL1310110005#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_12d868eb_e840_476b_b8b7_205aa4ceb4bc
initial concentration: NaN
constant: false
is encoded by: hsa:586
is: SBO:0000252
boundary condition: true
type: Species
is: P54687
initial amount: NaN
has only substance units: false
name: BCAT1

metaR r0527
kinetic law: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
fast: false
is: SBO:0000176
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
reactant: MODEL1310110005#
type: Reaction
reversible: true
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_22ed7e78_cbc6_4321_8920_58fc71a77e45
is encoded by: hsa:2181
initial amount: NaN
is: O95573
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: ACSL3
is: SBO:0000252
type: Species

metaM HC02203 c
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: CHEBI:27820
name: prostaglandin-a2

metaR TRIOK
is described by: ECO:0000000
name: triokinase
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.28 Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110005#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110005#_09c8746e_695a_4865_a3d1_cba16e04c43b
name: ACO2
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: Q99798
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:50

http://identifiers.org/biomodels.db/MODEL1310110005#_c9658896_5071_4706_9e9f_2d35d06004a0
is: P30048
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:10935
constant: false
is: SBO:0000252
name: PRDX3
initial amount: NaN

metaM mercplaccys e
type: Species
boundary condition: false
is: HMDB06512
constant: false
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
has only substance units: false
name: 3-mercaptolactate-cysteine disulfide
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

metaR r0170
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110005#
type: Reaction
modifier: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.40

metaR r0399
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false
is described by: ECO:0000000
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:

metaR AHCYStd
reversible: true
kinetic law: MODEL1310110005#
is described by: ECO:0000134
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
reactant: MODEL1310110005#
name: diffusion of S-Adenosyl-L-homocysteine
product: MODEL1310110005#
type: Reaction

metaR EX sarcs LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sarcosine exchange
type: Reaction

metaR ORNt4m
fast: false
reactant: MODEL1310110005#
reversible: true
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
modifier: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
product: MODEL1310110005#
name: ornithine mitochondrial transport exchange with citruline

metaR ADKd
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#
modifier: MODEL1310110005#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is: SBO:0000176
reactant: MODEL1310110005#
type: Reaction
name: adenylate kinase (d form)

metaM 2hb c
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
name: 2-Hydroxybutyrate
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00008
is: CHEBI:1148

metaR r2379
kinetic law: MODEL1310110005#
product: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110005#

metaM HC00460 c
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:58044
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
has only substance units: false
name: 2,5-dihydroxybenzoate
initial concentration: 1.0
constant: false

metaM lnlnca l
type: Species
name: alpha-linolenate
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB01388
boundary condition: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
initial amount: NaN
is: CHEBI:32387
constant: false

metaR ECOAH1m
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: true
reactant: MODEL1310110005#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.18
fast: false
type: Reaction
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
product: MODEL1310110005#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110005#_72f9e56d_2352_45f2_8a5e_93954fadb8ce
initial concentration: NaN
initial amount: NaN
name: ADA
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:100
is: P00813
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_e12b98a7_4b6e_4323_8c3d_ba848c6a2100
initial concentration: NaN
type: Species
name: ALDOA
is: SBO:0000252
is encoded by: hsa:226
initial amount: NaN
has only substance units: false
is: P04075
constant: false
boundary condition: true

metaR CYSGLUexR
modifier: MODEL1310110005#
product: MODEL1310110005#
kinetic law: MODEL1310110005#
type: Reaction
is: SBO:0000185
is described by: ECO:0000304
reversible: true
reactant: MODEL1310110005#
fast: false
name: L-cysteine/L-glutamine reversible exchanger
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

metaR RE3245C
is described by: ECO:0000000
product: MODEL1310110005#
type: Reaction
reactant: MODEL1310110005#
name: RE3245
is: SBO:0000176
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
reversible: true
fast: false

metaR ABUTt2r
fast: false
product: MODEL1310110005#
is described by: ECO:0000304
reactant: MODEL1310110005#
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
name: 4-aminobutyrate reversible transport in via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r

metaR r1994
modifier: MODEL1310110005#
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_736d0955_f92b_4214_8fec_c7a77bf33026
type: Species
is encoded by: hsa:4720
initial amount: NaN
is: B7Z792
boundary condition: true
constant: false
is: SBO:0000252
name: NDUFS2
has only substance units: false
initial concentration: NaN

metaR r1670
reversible: true
type: Reaction
product: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110005#
is: SBO:0000185
name: Y+LAT2 Utilized transport
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false

metaM dtdp e
boundary condition: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
has only substance units: false
is: CHEBI:58369
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110005#_1f66877f_adf9_451a_a0c4_f5fe66a7e1b1
initial amount: NaN
is encoded by: hsa:8833
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: P49915
name: GMPS
has only substance units: false
is: SBO:0000252

metaR RE1517M
is described by: ECO:0000000
reversible: true
is: SBO:0000176
name: RE1517
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110005#
product: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_8ec92a8b_97e9_4df0_be22_4b84a2ffa311
initial amount: NaN
name: AHCY
initial concentration: NaN
is: B3KUN3
type: Species
is encoded by: hsa:191
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaM srtn e
initial concentration: 1.0
has only substance units: false
is: CHEBI:350546
name: serotonin(1+)
is: SBO:0000247
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: HMDB00259
type: Species
initial amount: NaN
constant: false
boundary condition: false

metaM prpncoa m
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:57367
name: acryloyl-CoA(4-)
is: HMDB02307
constant: false
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110005#_8c308f0d_c629_4461_97d0_f225668cb012
is: Q9BQG2
initial amount: NaN
is encoded by: hsa:83594
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: NUDT12
has only substance units: false
boundary condition: true

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR ILETAm
is described by: ECO:0000269
type: Reaction
product: MODEL1310110005#
fast: false
name: isoleucine transaminase, mitochondrial
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
reactant: MODEL1310110005#
reversible: true

metaR r2372
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110005#_57d13230_58c3_49ce_9553_b4073c17a89d
constant: false
is: SBO:0000252
initial amount: NaN
is: Q9NRZ7
is encoded by: hsa:56894
name: AGPAT3
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110005#_f2a65caf_81ef_4f4d_b76b_0b43df525a47
has only substance units: false
is: SBO:0000252
name: SLC25A21
is encoded by: hsa:89874
is: G3V4L5
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_b60bfb2f_db9f_420a_97f6_dda082ebac70
is encoded by: hsa:3550
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: IK
is: Q13123

metaR r2195
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110005#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185

metaR SPODMn
modifier: MODEL1310110005#
fast: false
reversible: false
name: superoxide dismutase, nuclear
product: MODEL1310110005#
is described by: ECO:0000269
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.15.1.1
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
is: SBO:0000176
type: Reaction

metaM mercplac c
is: HMDB02127
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/8118
type: Species
boundary condition: false
name: 3-Mercaptolactate
constant: false
has only substance units: false
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
is: C05823
is: SBO:0000247
initial amount: NaN

metaM xtsn c
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
initial concentration: 1.0
initial amount: NaN
is: HMDB00299
has only substance units: false
name: xanthosine
is: CHEBI:18107
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_9fe55045_c38b_45dc_b877_84373a10cec6
name: OXSM
is: SBO:0000252
is encoded by: hsa:54995
is: Q9NWU1
initial amount: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR MCITS
name: 2-methylcitrate synthase
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 2.3.3.5 Confidence Level: 2 AUTHORS: PMID:426765,PMID:4507604 NOTES:NCD new EC is 2.3.3.5 - NCD
reactant: MODEL1310110005#

metaR r0287
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: false
kinetic law: MODEL1310110005#
product: MODEL1310110005#
is: SBO:0000176
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
modifier: MODEL1310110005#
reactant: MODEL1310110005#
is described by: ECO:0000000

metaR DM btn
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for biotin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_8eb1b811_4097_4873_b89f_7c12f21c9a84
is: SBO:0000252
boundary condition: true
has only substance units: false
name: ECI1
type: Species
is encoded by: hsa:1632
initial amount: NaN
is: P42126
constant: false
initial concentration: NaN

metaR r0321
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is described by: ECO:0000000
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
reactant: MODEL1310110005#
product: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/6.3.5.2
reversible: false
fast: false

metaM dtdp c
initial amount: NaN
is: HMDB01274
type: Species
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
is: SBO:0000247
is: CHEBI:58369
constant: false
initial concentration: 1.0
name: dTDP
has only substance units: false
is: C00363

metaR ADPtx
is: SBO:0000185
reactant: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
kinetic law: MODEL1310110005#
product: MODEL1310110005#
name: ADP transporter, peroxisomal
reversible: true
fast: false
type: Reaction

metaM CE5101 m
type: Species
has only substance units: false
boundary condition: false
constant: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
is: CHEBI:57795

metaM dhf m
name: dihydrofolate(2-)
is: CHEBI:57451
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB01056
boundary condition: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
type: Species

metaR PItx
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110005#
name: Phosphate transporter, peroxisome
fast: false
reversible: true
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_c9ee4e8c_d95c_44b7_8ead_c2e1beea0602
initial amount: NaN
type: Species
is: Q8N1Q1
has only substance units: false
constant: false
is encoded by: hsa:377677
is: SBO:0000252
name: CA13
boundary condition: true
initial concentration: NaN

metaR GLYC3PFADm
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110005#
fast: false
product: MODEL1310110005#
name: glycerophosphate shuttle for trasnfer of reducing equivalents
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110005#_26bd6bcc_cb00_4347_a526_c168915544a4
name: ACO2
type: Species
initial amount: NaN
initial concentration: NaN
is: Q99798
boundary condition: true
is encoded by: hsa:50
is: SBO:0000252
constant: false
has only substance units: false

metaR r2373
reversible: true
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_07bfc5dc_7c0c_42d4_a1e3_77d83ff87ca4
has only substance units: false
is: SBO:0000252
name: _AU149534_1_e
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:AU149534
constant: false

metaR r2194
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110005#
is: SBO:0000185
reactant: MODEL1310110005#
modifier: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110005#
is described by: ECO:0000000
type: Reaction

metaM pmtcoa r
is: SBO:0000247
initial amount: NaN
is: CHEBI:3454
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
constant: false
initial concentration: 1.0
is: HMDB01338
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4

metaR r0926
type: Reaction
name: Postulated transport reaction
kinetic law: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
reversible: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
fast: false
is described by: ECO:0000000

metaR r1088
reactant: MODEL1310110005#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
name: Active transport
fast: false

metaR SPODMm
reversible: false
reactant: MODEL1310110005#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
name: superoxide dismutase
is described by: ECO:0000304
modifier: MODEL1310110005#
fast: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.15.1.1

http://identifiers.org/biomodels.db/MODEL1310110005#_1880757c_1017_4685_8442_4165f7b13e44
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: O00154
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:11332
name: ACOT7

http://identifiers.org/biomodels.db/MODEL1310110005#_8359ec7c_87ff_48af_972e_8d376f429928
type: Species
initial concentration: NaN
is: SBO:0000252
name: SOD1
boundary condition: true
initial amount: NaN
constant: false
is: P00441
is encoded by: hsa:6647
has only substance units: false

metaR HIBDm
is version of: http://identifiers.org/ec-code/1.1.1.31
reversible: true
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110005#
type: Reaction
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
reactant: MODEL1310110005#
fast: false
modifier: MODEL1310110005#
product: MODEL1310110005#

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaR r1991
product: MODEL1310110005#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110005#
type: Reaction
fast: false
kinetic law: MODEL1310110005#
reversible: false
is: SBO:0000185

metaM HC01162 c
is: CHEBI:58376
constant: false
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
type: Species
has only substance units: false

metaM nadh x
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487
initial concentration: 1.0
is: SBO:0000247
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
constant: false
is: C00004
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_d267f3a9_e1db_48ec_b10d_1254bbad7567
is: SBO:0000252
is encoded by: hsa:AI640625
boundary condition: true
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
name: _AI640625_1_c

metaR r2197
product: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110005#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_f6538668_37c0_4403_8489_24f256c13f3d
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3992
type: Species
initial amount: NaN
has only substance units: false
name: FADS1
is: O60427

metaR r2374
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
product: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
fast: false
type: Reaction

metaM HC01115 c
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
is: CHEBI:29025
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: NeuNGc

http://identifiers.org/biomodels.db/MODEL1310110005#_ab343d64_3451_4482_9680_107f31d84a84
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:7001
name: PRDX2
is: SBO:0000252
initial concentration: NaN
constant: false

metaM leu L c
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:15603
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
boundary condition: false
constant: false
is: HMDB00687
initial amount: NaN
has only substance units: false
name: L-leucine

metaR PGCD
product: MODEL1310110005#
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
name: phosphoglycerate dehydrogenase
is version of: http://identifiers.org/ec-code/1.1.1.95
type: Reaction
is: SBO:0000176
reactant: MODEL1310110005#
fast: false
reversible: false
is described by: ECO:0000269

metaR r1990
reactant: MODEL1310110005#
product: MODEL1310110005#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR NDPK9
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:IDP)
reversible: true
kinetic law: MODEL1310110005#
modifier: MODEL1310110005#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
reactant: MODEL1310110005#
product: MODEL1310110005#
is described by: ECO:0000269

metaM 23cump e
is: SBO:0000247
initial concentration: 1.0
name: 2',3'-cyclic UMP(1-)
boundary condition: false
constant: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H10N2O8P CHARGE: -1 INCHI: InChI=1S/C9H11N2O8P/c12-3-4-6-7(19-20(15,16)18-6)8(17-4)11-2-1-5(13)10-9(11)14/h1-2,4,6-8,12H,3H2,(H,15,16)(H,10,13,14)/p-1/t4-,6-,7-,8-/m1/s1 EHMN_ABBREVIATION: C02355
is: CHEBI:60873

metaM glyclt x
constant: false
initial concentration: 1.0
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
type: Species
name: glycolate
has only substance units: false
is: CHEBI:29805
boundary condition: false
is: SBO:0000247
is: HMDB00115
initial amount: NaN

metaR r0062
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.1 Confidence Level: 0 AUTHORS: PMID:11322891,PMID:12545200,PMID:16951743,PMID:34392,PMID:6151837,PMID:7696329 NOTES:
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110005#
is: SBO:0000176
kinetic law: MODEL1310110005#
product: MODEL1310110005#
name: Acetyl-CoA hydrolase Pyruvate metabolism EC:3.1.2.1
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/4.3.1.17

metaR ALASm
reactant: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.29
reversible: false
is described by: ECO:0000254
product: MODEL1310110005#
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
type: Reaction
name: 5-aminolevulinate synthase
fast: false
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/2.3.1.37
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110005#_a7196522_14ab_4d7f_99cc_57ed68c31be9
name: _AI222095_1_m
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI222095
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species

metaR HMGLm
fast: false
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
is: SBO:0000176
name: hydroxymethylglutaryl-CoA lyase
is described by: ECO:0000134
type: Reaction
modifier: MODEL1310110005#
kinetic law: MODEL1310110005#
is version of: http://identifiers.org/ec-code/4.1.3.4
product: MODEL1310110005#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110005#_39beb3ef_5af0_4365_8266_fbb09d9b2d09
is: P43304
constant: false
is: SBO:0000252
boundary condition: true
name: GPD2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2820
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_4788021c_8c65_4c9c_9d24_231bbe1fcf4a
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q9NYQ3
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:51179
name: HAO2

http://identifiers.org/biomodels.db/MODEL1310110005#_8ae33977_5c37_4a21_8868_8d98257d74fd
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5959
initial amount: NaN
constant: false
name: RDH5
has only substance units: false
type: Species
is: Q92781

http://identifiers.org/biomodels.db/MODEL1310110005#_c8c927bf_71df_4d93_9a6a_1fa949ec91b8
is: Q96P26
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:93034
name: NT5C1B
type: Species
boundary condition: true

metaR URIt5le
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: uridine transport in via sodium symport (1:2)
kinetic law: MODEL1310110005#
reversible: false
product: MODEL1310110005#
is: SBO:0000185
fast: false
type: Reaction
modifier: MODEL1310110005#
is described by: ECO:0000134
reactant: MODEL1310110005#

metaR r2375
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
product: MODEL1310110005#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110005#
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110005#

metaM bamppald c
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
constant: false
is: SBO:0000247
is: HMDB01106
type: Species
initial amount: NaN
is: C05665
name: beta-Aminopropion aldehyde
has only substance units: false
is: http://identifiers.org/pubchem.compound/7975

metaR r2196
fast: false
modifier: MODEL1310110005#
product: MODEL1310110005#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true

metaR r1291
type: Reaction
fast: false
product: MODEL1310110005#
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: true
kinetic law: MODEL1310110005#
is described by: ECO:0000000
reactant: MODEL1310110005#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110005#_5e95d250_8784_47fb_8434_c7e92ceb2b37
is encoded by: hsa:9056
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q9UM01
name: SLC7A7
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_2a81df04_2fa4_4d31_84c8_347083c3ebda
is encoded by: hsa:8802
is: SBO:0000252
initial concentration: NaN
is: P53597
type: Species
constant: false
name: SUCLG1
initial amount: NaN
has only substance units: false
boundary condition: true

metaR PDHm
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.4.1
fast: false
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110005#
notes: GENE_ASSOCIATION: (1738.1 and 8050.1) and (5161.1 and 5162.1) and (1737.1) or (1738.1 and 8050.1) and (5160.1 and 5162.1) and (1737.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12372595,PMID:16436377 NOTES:12372595 - expression; 16436377 - biochemical, tissue-specific
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.8.1.4
name: pyruvate dehydrogenase
is version of: http://identifiers.org/ec-code/2.3.1.12

http://identifiers.org/biomodels.db/MODEL1310110005#_2f9caae8_610c_4bac_873b_3a550f49f3b8
constant: false
is: SBO:0000252
is: P05091
type: Species
name: ALDH2
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:217

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM ditp c
is: CHEBI:61382
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB03537
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
name: dITP(4-)
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110005#_01b74f47_74ff_4cb9_85df_f05f4181f77a
has only substance units: false
is: P23368
type: Species
constant: false
name: ME2
is encoded by: hsa:4200
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaM coa x
initial concentration: 1.0
is: CHEBI:57287
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
boundary condition: false
is: HMDB01423
type: Species
has only substance units: false
name: Coenzyme A
constant: false
is: C00010
is: SBO:0000247

metaM oh1 e
initial concentration: 1.0
name: hydroxide ion
is: HMDB01039
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C01328
notes: FORMULA: HO CHARGE: -1
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_46cdd17e_e401_4553_be86_b7618d351732
initial amount: NaN
initial concentration: NaN
is: B4DG68
constant: false
is encoded by: hsa:4842
type: Species
name: NOS1
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM 3sala c
is: CHEBI:61085
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: C00606
initial concentration: 1.0
name: 3-Sulfino-L-alanine
constant: false
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
is: SBO:0000247

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaM xol7aone c
name: 7alpha-hydroxycholest-4-en-3-one
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: CHEBI:17899
constant: false
is: HMDB01993
is: SBO:0000247

metaR NDPK2n
reversible: true
kinetic law: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110005#
modifier: MODEL1310110005#
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
product: MODEL1310110005#
is: SBO:0000176

metaM HC01842 c
type: Species
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: Phosphodimethylethanolamine
boundary condition: false
is: CHEBI:31997
is: SBO:0000247

metaM h2o2 x
is: HMDB03125
is: CHEBI:16240
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: Hydrogen peroxide
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
is: C00027
constant: false
initial concentration: 1.0

metaM leu L e
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:15603
is: HMDB00687
name: L-leucine
boundary condition: false
type: Species

metaM HC01409 m
type: Species
is: CHEBI:27540
name: Hexanoyl-CoA
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_a0169b88_188a_40e9_b87d_92dcb7fc772f
type: Species
name: AFMID
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:125061
is: Q63HM1
has only substance units: false
constant: false

metaM HC02179 e
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:34306
initial concentration: 1.0
name: 20-hydroxy-arachidonate
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_cad2f0d6_efe2_4376_bbe1_03fd7ca550a7
name: _U37519_1_e
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:U37519
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaR FAOXC2051843m
modifier: MODEL1310110005#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of fatty acid
fast: false
product: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
kinetic law: MODEL1310110005#
is: SBO:0000176
is described by: ECO:0000000

metaM pmtcoa x
is: HMDB01338
is: SBO:0000247
boundary condition: false
constant: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:57379

metaR r0391
is: SBO:0000176
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110005#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_41fdb3e8_9c38_46c4_9dac_677f41ea0633
boundary condition: true
initial concentration: NaN
name: LHPP
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:64077
is: Q9H008
constant: false

http://identifiers.org/biomodels.db/MODEL1310110005#_a42bc34f_2e89_4a2f_86fc_ed33d22eae87
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
name: SLC10A2
is encoded by: hsa:6555
constant: false
is: Q12908

metaR r0178
is described by: ECO:0000000
product: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.5.1.21
modifier: MODEL1310110005#
fast: false
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
kinetic law: MODEL1310110005#

metaR MALTSULtm
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110005#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#
product: MODEL1310110005#
name: Malate:thiosulfate antiport, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110005#_e9616d4e_042f_4ba7_b6ef_9a5a49b8501c
initial amount: NaN
has only substance units: false
name: LPGAT1
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:9926
constant: false
is: Q92604
is: SBO:0000252

metaM ctp c
is: C00063
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
is: CHEBI:37563
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00082
name: CTP

http://identifiers.org/biomodels.db/MODEL1310110005#_64567c06_2ea3_4d1f_b615_04dd232da0d7
is: SBO:0000252
boundary condition: true
is: B2R6S5
constant: false
type: Species
has only substance units: false
is encoded by: hsa:51727
name: CMPK1
initial concentration: NaN
initial amount: NaN

metaM so4 m
name: sulfate
is: CHEBI:16189
boundary condition: false
is: HMDB01448
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059

metaR r2193
modifier: MODEL1310110005#
is: SBO:0000185
product: MODEL1310110005#
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true

metaR r0899
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110005#
is described by: ECO:0000000
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
name: Amino acid transporter ATB0+ Facilitated diffusion

http://identifiers.org/biomodels.db/MODEL1310110005#_18fb7c76_4be4_48fb_aa04_b10fa4597059
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
is: P38571
type: Species
name: LIPA
initial amount: NaN
boundary condition: true
is encoded by: hsa:3988

metaM lnlnca e
is: CHEBI:32387
initial concentration: 1.0
name: alpha-linolenate
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
has only substance units: false
is: HMDB01388
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110005#_56902c06_f18a_4fe3_beca_9db714b48e68
constant: false
has only substance units: false
initial amount: NaN
name: _AI971036_1_x
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI971036
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110005#_121feddb_62b6_4193_881d_45e5f43839fc
is: SBO:0000252
is encoded by: hsa:1375
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: Q53FV7
name: CPT1B
type: Species

metaR DNDPt23m
product: MODEL1310110005#
modifier: MODEL1310110005#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
name: dTDP transport via dGTP antiport
reversible: false
reactant: MODEL1310110005#
kinetic law: MODEL1310110005#

metaR r0390
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
is: SBO:0000176
reactant: MODEL1310110005#
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
kinetic law: MODEL1310110005#
reversible: true
is described by: ECO:0000000
product: MODEL1310110005#

http://identifiers.org/biomodels.db/MODEL1310110005#_070c431d_1c32_4762_a5ae_6a7c970b189f
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:4830
is: P15531
is: SBO:0000252
name: NME1
constant: false

metaR Htr
type: Reaction
product: MODEL1310110005#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110005#
is: SBO:0000185
kinetic law: MODEL1310110005#
name: H transporter, endoplasmic reticulum
is described by: ECO:0000000

metaR DM atp c
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
name: DM_atp(c)
fast: false
reactant: MODEL1310110005#
reversible: false
product: MODEL1310110005#
kinetic law: MODEL1310110005#
is described by: ECO:0000134
type: Reaction

metaR METS
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.1.13
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (4548.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.1.1.13 Confidence Level: 4 AUTHORS: PMID:8968736,PMID:9013615 NOTES:Human Y/N: Y
product: MODEL1310110005#
modifier: MODEL1310110005#
name: methionine synthase
fast: false

metaR UDPGLCter
reactant: MODEL1310110005#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
is: SBO:0000185
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
type: Reaction
product: MODEL1310110005#
fast: false
kinetic law: MODEL1310110005#
is described by: ECO:0000000

metaR LTD4DP
product: MODEL1310110005#
reversible: true
type: Reaction
kinetic law: MODEL1310110005#
fast: false
reactant: MODEL1310110005#
is: SBO:0000176
name: Leukotriene D4 dipeptidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110005#_e94fc60b_ec99_48be_a3dc_5e2485b18dfe
is encoded by: hsa:29968
type: Species
boundary condition: true
name: PSAT1
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false

metaR r0179
modifier: MODEL1310110005#
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.27
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
kinetic law: MODEL1310110005#
is described by: ECO:0000000
product: MODEL1310110005#
reactant: MODEL1310110005#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_71302d78_e280_405e_8326_34aeae66f6be
boundary condition: true
constant: false
is encoded by: hsa:8875
has part: O95498
name: VNN3:VNN2:VNN1
type: Species
is encoded by: hsa:55350
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110005#_3919fa7e_2e7e_4d8c_939c_c08b108fc642
is encoded by: hsa:6240
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: RRM1
type: Species
constant: false
is: P23921

metaM HC02179 c
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:34306
type: Species
is: SBO:0000247
constant: false
name: 20-hydroxy-arachidonate
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

metaM HC01406 m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
initial amount: NaN
constant: false
initial concentration: 1.0
name: 3-Oxooctanoyl-CoA
boundary condition: false
type: Species
is: CHEBI:28264

metaR r2371
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110005#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110005#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
kinetic law: MODEL1310110005#
fast: false

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110005#
reactant: MODEL1310110005#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110005#_3f226817_1f73_455c_9c58_52c6ee84b6db
type: Species
constant: false
is: B4DZR2
name: ALDH1A2
initial concentration: NaN
is encoded by: hsa:8854
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true

metaM citr L m
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: HMDB00904
is: CHEBI:16349
type: Species
initial amount: NaN
name: L-citrulline
has only substance units: false