metaR GGH 10FTHF5GLUe
fast: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reversible: false
type: Reaction
product: MODEL1310110004#
is: SBO:0000176
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
reactant: MODEL1310110004#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110004#

metaR FRDPtc
reactant: MODEL1310110004#
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
name: lipid, flip-flop intracellular transport

metaM 2octdectecoa x
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
constant: false
name: 2,6,9,12-octadecatetraenoylcoa
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_cf56eeb2_c951_4e9b_b4c3_d7424daf491d
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:8050
initial concentration: NaN
name: PDHX
type: Species
initial amount: NaN
is: O00330

http://identifiers.org/biomodels.db/MODEL1310110004#_9810dd91_29f6_4b13_9e68_df2b9c3ec93c
is: Q9HAB8
name: PPCS
has only substance units: false
constant: false
is encoded by: hsa:79717
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

metaR GLYt2r
type: Reaction
product: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reversible: true
is: SBO:0000185
fast: false
name: glycine reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is described by: ECO:0000304
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_cc23aea5_5987_494d_9e8f_c620af192c9c
initial concentration: NaN
is encoded by: hsa:8833
is: SBO:0000252
name: GMPS
initial amount: NaN
is: P49915
constant: false
boundary condition: true
type: Species
has only substance units: false

metaM arachdcoa c
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:57368
type: Species
name: arachidonoyl-CoA(4-)
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: SBO:0000247
initial concentration: 1.0
is: HMDB06523

metaR NDP7ex
modifier: MODEL1310110004#
is described by: ECO:0000269
fast: false
name: nucleoside-diphosphatase (UDP), extracellular
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000176
reversible: false
product: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:

metaM nrpphr c
has only substance units: false
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: SBO:0000247
is: HMDB00216
boundary condition: false
name: Norepinephrine
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:33569

metaR DURItn
kinetic law: MODEL1310110004#
fast: false
product: MODEL1310110004#
is described by: ECO:0000000
reversible: true
name: deoxyuridine transport in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110004#
is: SBO:0000185
type: Reaction

metaR r2124
kinetic law: MODEL1310110004#
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110004#
reactant: MODEL1310110004#
fast: false

metaM h m
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
has only substance units: false
name: proton
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:24636
is: C00080
initial amount: NaN
constant: false

metaM undcoa m
initial amount: NaN
boundary condition: false
name: undecanoylcoa
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB13114
notes: FORMULA: C32H52N7O17P3S CHARGE: -4
type: Species

metaR GALASE17ly
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
type: Reaction
name: beta-galactosidase, lysosomal
reactant: MODEL1310110004#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110004#

metaR RE1516M
name: RE1516
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
type: Reaction
product: MODEL1310110004#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110004#
modifier: MODEL1310110004#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110004#

metaR ANTHte
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
name: Transport of anthranilate
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_4ead59f3_4011_4962_956c_e34db4a135f6
is: Q9H3S5
constant: false
type: Species
is: SBO:0000252
name: PIGM
initial amount: NaN
has only substance units: false
is encoded by: hsa:93183
boundary condition: true
initial concentration: NaN

metaR DIDPtn
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110004#
is: SBO:0000185
type: Reaction
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110004#
name: dIDP nuclear transport

metaM tmndnc e
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB01999
is: http://identifiers.org/pubchem.compound/446284
has only substance units: false
name: timnodonic acid C20:5, n-3
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_12f5fdbb_c4ce_4bf7_a6e7_f4c12be16f98
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
name: CDS2
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8760
is: O95674

metaR EX c5dc
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glutaryl carnitine
type: Reaction

metaR r0603
fast: false
is described by: ECO:0000000
product: MODEL1310110004#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.12
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is: SBO:0000176
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12

metaR PHEMEt
kinetic law: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (113235.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:16143108 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110004#
name: heme transport
modifier: MODEL1310110004#
fast: false
reversible: false

metaR FAOXC12C10x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)x
type: Reaction

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaR r1377
is: SBO:0000176
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:

metaR EX eicostet LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: eicosatetranoic acid exchange
type: Reaction

metaM h l
is: SBO:0000247
name: proton
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
is: C00080
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: "
initial amount: NaN
type: Species

metaM adpac c
initial amount: NaN
constant: false
is: HMDB00448
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H8O4 CHARGE: -2
name: adipic acid
type: Species

metaR HEX4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.1
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.2
fast: false
modifier: MODEL1310110004#
name: hexokinase (D-mannose:ATP)
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000304
reactant: MODEL1310110004#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110004#_b721babf_7a9b_45e8_8c45_86c51edd9709
constant: false
type: Species
is encoded by: hsa:506
has only substance units: false
name: ATP5B
initial amount: NaN
boundary condition: true
is: P06576
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_ae1a1842_419f_4421_b191_c19d03791d85
is: Q9UN76
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:11254
constant: false
boundary condition: true
is: SBO:0000252
name: SLC6A14
initial concentration: NaN

metaR RE1342C
kinetic law: MODEL1310110004#
fast: false
type: Reaction
reversible: true
name: RE1342
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
product: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_35be281f_6e8b_4968_bf89_ba02a7de21c3
initial concentration: NaN
boundary condition: true
is: P19440
is: SBO:0000252
is encoded by: hsa:2678
type: Species
has only substance units: false
name: GGT1
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_6afcca2c_7a66_4bdd_8cad_235ec9c9ea34
name: _AL048840_1_c
is encoded by: hsa:AL048840
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_dff84c1a_b245_4971_ad86_985265d8f75b
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: NDUFB6
is: Q5VYT2
is encoded by: hsa:4712
has only substance units: false
constant: false

metaR EX tdcrn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for myristoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_eefbc482_d17d_4462_8a5c_a89e3b7a7c11
is: Q92604
is encoded by: hsa:9926
has only substance units: false
constant: false
initial concentration: NaN
name: LPGAT1
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_f5e1922d_b4f6_4ce1_8660_b91c1b4d98cc
has only substance units: false
is: SBO:0000252
is: Q9Y4C5
name: CHST2
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9435

metaM glu5sa m
has only substance units: false
is: HMDB02104
name: L-Glutamate 5-semialdehyde
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:17232
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: SBO:0000247
constant: false
is: C01165
initial concentration: 1.0

metaR r1588
fast: false
is: SBO:0000185
product: MODEL1310110004#
reversible: true
type: Reaction
kinetic law: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110004#

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaM ps hs c
constant: false
has only substance units: false
name: ps_hs[c]
boundary condition: false
initial amount: NaN
is: CHEBI:18303
type: Species
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0
is: SBO:0000247

metaM dpcoa c
name: Dephospho-CoA
type: Species
boundary condition: false
is: HMDB01373
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: C00882
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:57328
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_60b7c3b1_96db_4465_a797_8e46a62671c8
is: SBO:0000252
is encoded by: hsa:518
boundary condition: true
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: ATP5G3
initial concentration: NaN

metaR r2126
reactant: MODEL1310110004#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_fc2ac292_21c8_484f_86ba_1a2e276b3d5a
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:55293
initial amount: NaN
is: Q8IX04
initial concentration: NaN
name: UEVLD

metaR HEX7
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.1.1
is version of: http://identifiers.org/ec-code/2.7.1.2
name: hexokinase (D-fructose:ATP)
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
modifier: MODEL1310110004#
reversible: false
fast: false
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110004#

metaR EX acgam LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-D-glucosamine exchange
type: Reaction

metaM cmp g
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
boundary condition: false
initial amount: NaN
constant: false
name: CMP(2-)
is: HMDB00095
is: CHEBI:60377
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

metaR GLYK
notes: GENE_ASSOCIATION: (2710.2) or (2712.1) or (2710.1) or (2713.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
is described by: ECO:0000269
kinetic law: MODEL1310110004#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.30
fast: false
name: glycerol kinase
is: SBO:0000176

metaR AHC
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
name: adenosylhomocysteinase
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (191.1) or (10768.2) or (10768.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 3.3.1.1 Confidence Level: 4 AUTHORS: PMID:12590576,PMID:2596825 NOTES:
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.3.1.1
reversible: true
product: MODEL1310110004#

metaR FAOXC150m
name: Beta oxidation of long chain fatty acid (odd chain)
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110004#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110004#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ

metaM tmndnc c
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: HMDB01999
name: timnodonic acid C20:5, n-3
is: http://identifiers.org/pubchem.compound/446284
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-

http://identifiers.org/biomodels.db/MODEL1310110004#_dc0a2b58_ef21_4046_ac74_ec9366ff588e
type: Species
is encoded by: hsa:AA664770
is: SBO:0000252
initial amount: NaN
name: _AA664770_1_m
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM csn c
is: HMDB00630
is: SBO:0000247
has only substance units: false
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
initial amount: NaN
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:16040
name: cytosine

http://identifiers.org/biomodels.db/MODEL1310110004#_d834a9f9_becd_468d_9416_8ea73b9a4af9
initial amount: NaN
boundary condition: true
name: _AI090874_1_c
is encoded by: hsa:AI090874
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false

metaM 44mzym r
type: Species
initial concentration: 1.0
name: 14-demethyllanosterol
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
has only substance units: false
is: HMDB01286
is: CHEBI:18364

metaR r1375
reversible: false
fast: false
is: SBO:0000185
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
is described by: ECO:0000000

metaR r1589
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reversible: true
reactant: MODEL1310110004#
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaR KSII CORE4tly
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: keratan sulfate II (core 4) transport, extracellular to lysosome
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185

metaR r2127
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185
reactant: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is described by: ECO:0000000

metaM h n
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:24636
initial amount: NaN
constant: false
has only substance units: false
name: proton
boundary condition: false

metaR r2014
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110004#
is: SBO:0000185
product: MODEL1310110004#
reversible: false
fast: false

metaM g1m8mpdol U r
constant: false
is: SBO:0000247
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
boundary condition: false
is: CHEBI:59093
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_a05917d0_6e81_4a43_9097_a2c91826bd70
boundary condition: true
constant: false
initial concentration: NaN
name: TXNRD2
is encoded by: hsa:10587
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_49d9a0be_b700_462c_826f_df3863022f00
constant: false
is encoded by: hsa:1891
boundary condition: true
type: Species
name: ECH1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q13011

metaM 6pgc r
is: CHEBI:58759
initial concentration: 1.0
is: SBO:0000247
is: HMDB01316
type: Species
name: 6-phosphonatooxy-D-gluconate
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345

metaM dheas e
initial amount: NaN
constant: false
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
initial concentration: 1.0
type: Species
is: HMDB01032
has only substance units: false
is: CHEBI:57905
is: SBO:0000247
boundary condition: false
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)

http://identifiers.org/biomodels.db/MODEL1310110004#_a953ba7b_ec2d_40aa_80bf_41a1f27eb328
name: GALNS
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: P34059
boundary condition: true
is encoded by: hsa:2588
has only substance units: false
is: SBO:0000252

metaM sucr e
type: Species
has only substance units: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00091 EHMN_ABBREVIATION: C00089
is: CHEBI:17992
name: Sucrose
is: C00089
is: HMDB00258
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false

metaR r2128
is described by: ECO:0000000
product: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185
reversible: true
type: Reaction

metaM 3deccrn e
has only substance units: false
name: 3-hydroxydecanoylcarnitine
notes: FORMULA: C17H33NO5 CHARGE: 0
initial amount: NaN
is: HMDB02250
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM csn e
name: cytosine
boundary condition: false
initial concentration: 1.0
is: HMDB00630
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
constant: false
type: Species
has only substance units: false
is: CHEBI:16040

metaM nadph r
is: HMDB00221
is: CHEBI:57783
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
is: C00005
has only substance units: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
type: Species

metaM co2 e
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
is: HMDB01967
initial amount: NaN
is: C00011
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: CO2
initial concentration: 1.0

metaM cmp e
name: CMP(2-)
is: CHEBI:60377
type: Species
initial amount: NaN
is: HMDB00095
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0

metaM hs deg5 l
boundary condition: false
name: heparan sulfate, degradation product 5
has only substance units: false
is: CHEBI:17895
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00158
notes: FORMULA: C67H97N4O86S10 CHARGE: -11
initial concentration: 1.0

metaM gal l
type: Species
name: D-galactose
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
is: HMDB00143
boundary condition: false
initial concentration: 1.0
is: CHEBI:12936
is: SBO:0000247

metaR S6TASE1ly
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000000
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
type: Reaction

metaR r2129
is: SBO:0000185
product: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_71c97a1c_0a01_41df_bcd4_cc69d4241cdb
is: Q6ZWT7
is encoded by: hsa:129642
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: MBOAT2
type: Species
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_2838cdb4_9ddb_49a6_9be7_f5948c3d7378
is: SBO:0000252
name: CYP7A1
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P22680
is encoded by: hsa:1581
type: Species

metaR TETPENT6COAtx
fast: false
is: SBO:0000185
reversible: true
name: fatty acid intracellular transport
kinetic law: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#

metaM for r
name: Formate
is: SBO:0000247
is: HMDB00142
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:15740
type: Species
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: C00058
initial concentration: 1.0
has only substance units: false

metaM dheas c
is: SBO:0000247
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: HMDB01032
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
boundary condition: false
is: CHEBI:57905

metaM guln c
type: Species
is: SBO:0000247
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
is: HMDB03290
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:13115
name: L-gulonate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_bb6b62ae_5700_46a1_90d5_77077b72cfd7
has only substance units: false
is: B3KTV4
name: ADSSL1
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:122622
boundary condition: true
is: SBO:0000252

metaR RE3347C
name: RE3347
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
reversible: true
kinetic law: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110004#
fast: false

metaM occoa m
is: HMDB01070
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: SBO:0000247
is: C01944
boundary condition: false
name: Octanoyl-CoA (n-C8:0CoA)
is: CHEBI:57386
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_5fa2deb9_f1ee_4af8_af6c_ac4775d1f966
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: SLC34A1
is encoded by: hsa:6569
boundary condition: true
is: Q7Z725
initial concentration: NaN

metaM coa r
initial amount: NaN
is: HMDB01423
boundary condition: false
is: CHEBI:57287
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: C00010
initial concentration: 1.0
name: Coenzyme A
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaR CRNrtx
reactant: MODEL1310110004#
is described by: ECO:0000134
fast: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#
name: reversible transport of L-Carnitine in peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: added during gap filling. NOTES:added during gap filling.
type: Reaction
reversible: true
is: SBO:0000185

metaM chsterol r
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
type: Species
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
name: cholesterol
initial amount: NaN
is: CHEBI:16113

http://identifiers.org/biomodels.db/MODEL1310110004#_1168a32a_e251_4074_ac22_49ba57cc78d3
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:125965
is: Q6YFQ2
constant: false
boundary condition: true
name: COX6B2
initial amount: NaN

metaR LNLNCGt
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
reactant: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
is: SBO:0000185

metaR r1378
kinetic law: MODEL1310110004#
reversible: true
fast: false
is: SBO:0000176
product: MODEL1310110004#
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
type: Reaction
is described by: ECO:0000000

metaR GALASE1ly
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110004#
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176

metaM oxa m
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB02329
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:30623
name: oxalate(2-)

http://identifiers.org/biomodels.db/MODEL1310110004#_a769970e_990b_4bb1_8ec5_705f39e02f16
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
name: SDS
is: P20132
type: Species
boundary condition: true
is encoded by: hsa:10993

W3 CDTF: Fri Aug 31 05:28:28 BST 2012

metaM udpglcur r
initial amount: NaN
has only substance units: false
name: UDP-D-glucuronate
is: CHEBI:58052
boundary condition: false
is: HMDB00935
is: C00167
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
constant: false

metaM nrpphr e
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: Norepinephrine
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: CHEBI:33569
is: HMDB00216

http://identifiers.org/biomodels.db/MODEL1310110004#_513fd046_018b_4d1f_b8d4_8f7d99892602
initial amount: NaN
type: Species
name: OGDH
has only substance units: false
is: Q02218
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4967
constant: false
boundary condition: true

metaR EX cspg c LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan exchange
type: Reaction

metaM co2 c
constant: false
type: Species
has only substance units: false
is: HMDB01967
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0
name: CO2
is: C00011
is: CHEBI:3313
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM cmp c
constant: false
is: CHEBI:60377
type: Species
is: C00055
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: HMDB00095
name: CMP
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaM 3deccrn c
constant: false
is: HMDB00651
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C17H33NO5 CHARGE: 0
boundary condition: false
initial concentration: 1.0
name: 3-hydroxydecanoylcarnitine

metaR SUCCt2m
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
product: MODEL1310110004#
name: succinate transport, mitochondrial
modifier: MODEL1310110004#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110004#
reversible: true

metaR CLS hs
reactant: MODEL1310110004#
type: Reaction
is: SBO:0000176
product: MODEL1310110004#
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (54675.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10799718 NOTES:NJ
name: cardiolipin synthase (homo sapiens)
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_e787391c_db0c_4477_afbc_307f9627dd94
has only substance units: false
constant: false
is: SBO:0000252
is: Q9H845
initial concentration: NaN
name: ACAD9
boundary condition: true
type: Species
is encoded by: hsa:28976
initial amount: NaN

metaM acglcgalgluside hs g
is: CHEBI:17103
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
name: N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide
type: Species
notes: FORMULA: C38H69N2O17FULLRCO CHARGE: 0
has only substance units: false

metaR HEX1
is: SBO:0000176
is described by: ECO:0000134
name: hexokinase (D-glucose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.2
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.1
type: Reaction
modifier: MODEL1310110004#
reactant: MODEL1310110004#

metaM h r
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
has only substance units: false
name: proton
boundary condition: false
initial concentration: 1.0
is: C00080

http://identifiers.org/biomodels.db/MODEL1310110004#_817f4891_5e35_4211_b6dc_dc2e2fc91ae0
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is: Q7GXZ1
has only substance units: false
initial amount: NaN
name: ND6
is encoded by: hsa:4541
boundary condition: true

W3 CDTF: Fri Aug 31 05:28:28 BST 2012

W3 CDTF: Fri Aug 31 05:28:29 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110004#_c6fa04a4_9daa_47b7_bc80_3ac21c10b85d
is: P20020
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:490
name: ATP2B1
is: SBO:0000252

metaR RTOTAL2t
type: Reaction
reactant: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL2 transport
is: SBO:0000185
kinetic law: MODEL1310110004#
fast: false
is described by: ECO:0000000
product: MODEL1310110004#

metaR NDPK1n
fast: false
reversible: true
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110004#
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110004#_5d202f3a_f511_4037_81f8_89dab22335fb
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: APRT
is encoded by: hsa:353
initial amount: NaN
is: P07741
boundary condition: true
constant: false

metaM tddedi2coa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
boundary condition: false
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00792
name: trans2,6dodecadienoylcoa
initial concentration: 1.0
is: C08277

metaR ALOX5
reversible: false
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:2829172 NOTES:cofactors + usage still not clear see version ALOX5b for ATP concomittant hydrolysis - literature notes in vitro requirement for Ca and ATP for activity in addition to Fe
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.34
name: Arachidonate 5-lipoxygenase
product: MODEL1310110004#
is described by: ECO:0000269
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110004#

W3 CDTF: Fri Aug 31 05:28:29 BST 2012

metaM co2 r
boundary condition: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
name: CO2
is: C00011
has only substance units: false
is: HMDB01967
is: CHEBI:16526
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0

metaM CE2417 m
initial amount: NaN
is: CHEBI:28387
type: Species
is: HMDB11123
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
is: SBO:0000247
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110004#_b9184b35_9917_4600_9b19_db78f3bd18d6
is: SBO:0000252
constant: false
initial concentration: NaN
is: E9PB82
type: Species
has only substance units: false
name: HSD17B4
boundary condition: true
is encoded by: hsa:3295
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_298bb585_8441_4153_98a6_0ce8e2ac20a1
constant: false
is: SBO:0000252
has only substance units: false
is: Q92685
name: ALG3
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:10195
type: Species

metaM lgnc e
is: SBO:0000247
constant: false
name: lignocerate
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
is: CHEBI:31014
initial concentration: 1.0
is: HMDB02003

http://identifiers.org/biomodels.db/MODEL1310110004#_6b20fc82_d4b6_48a4_aea9_acae88ca40f9
initial concentration: NaN
name: _AI191472_1_c
initial amount: NaN
is encoded by: hsa:AI191472
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false

metaR C142CPT1
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

metaR HMGCOAtx
is described by: ECO:0000000
fast: false
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ

metaM paf hs e
boundary condition: false
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
has only substance units: false
constant: false
is: CHEBI:36707
initial concentration: 1.0
type: Species
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_88a4e145_995d_4efc_8408_65e1f7e9de03
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:5144
name: PDE4D
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is: Q08499

metaR r0706
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
type: Reaction
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110004#
fast: false
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.99.10
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_c5ec150c_518c_4a2a_a6cb_b9c60c0ab922
type: Species
is encoded by: hsa:10476
has only substance units: false
name: ATP5H
boundary condition: true
is: A0PJH2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_5157bebd_fc5d_4632_a0c5_7baedfdcf7b6
is encoded by: hsa:22934
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: RPIA
type: Species
initial amount: NaN
constant: false
is: P49247

metaR GLYt7 211 r
name: glycine reversible transport via sodium and chloride symport (2:1:1)
product: MODEL1310110004#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
is: SBO:0000185
reversible: true
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_91c37a1c_f836_404f_ac06_2dbf6a883b60
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:23428
name: SLC7A8
is: SBO:0000252
has only substance units: false
type: Species
is: Q9UHI5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_beaf81bd_b6aa_499d_8444_8bc58b5b6f2c
is encoded by: hsa:10317
boundary condition: true
constant: false
type: Species
name: B3GALT5
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_00361150_dbd2_462a_a479_369a40c1e3a3
is: Q8NCI4
constant: false
initial concentration: NaN
boundary condition: true
name: PIGG
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:54872
has only substance units: false
type: Species

metaM occoa x
initial amount: NaN
is: C01944
has only substance units: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
boundary condition: false
is: CHEBI:57386
initial concentration: 1.0
is: HMDB01070
type: Species
constant: false
name: Octanoyl-CoA (n-C8:0CoA)
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_0dcde871_1470_4e2b_9cf1_14c7b7bf21f9
type: Species
name: AICDA
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q546Y9
is encoded by: hsa:57379
has only substance units: false
constant: false
initial concentration: NaN

metaR GNMT
kinetic law: MODEL1310110004#
fast: false
reversible: false
modifier: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (27232.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.1.20 Confidence Level: 4 AUTHORS: PMID:10843803,PMID:11810299 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.1.20
reactant: MODEL1310110004#
name: glycine N-methyltransferase
type: Reaction

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaM 3pg c
initial concentration: 1.0
is: HMDB00807
is: SBO:0000247
name: 3-Phospho-D-glycerate
is: http://identifiers.org/pubchem.compound/3497
boundary condition: false
is: CHEBI:58272
constant: false
type: Species
has only substance units: false
is: C00197
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_galacglcgalacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
name: I-antigen
type: Species
initial amount: NaN
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
constant: false
is: CHEBI:26174
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR HIStN1
product: MODEL1310110004#
is described by: ECO:0000269
name: Histidine transport (Na, H coupled)
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
modifier: MODEL1310110004#
fast: false
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_a40cebe2_af87_4ebd_b7c0_45611ee2d7d0
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: UCK1
is: SBO:0000252
initial concentration: NaN
is: Q5JT09
boundary condition: true
is encoded by: hsa:83549

metaM 35cgmp c
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
is: HMDB01314
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57746
initial amount: NaN
name: 3',5'-cyclic GMP(1-)
boundary condition: false
has only substance units: false

metaR ATP2ter
product: MODEL1310110004#
reversible: true
name: AMP/ATP transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110004#_3ef4bd43_bf07_48b0_9fb3_e436b6430cc6
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10948
boundary condition: true
name: STARD3
type: Species
constant: false
is: B4DUY1
initial amount: NaN
initial concentration: NaN

metaR KYNAKGAT
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: false
product: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
name: L-Kynurenine:2-oxoglutarate aminotransferase
is version of: http://identifiers.org/ec-code/2.6.1.7
modifier: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_e8ed3681_20ab_4763_a841_cafd45d1721f
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: AK2
type: Species
constant: false
is encoded by: hsa:204
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_becaf59e_f9bd_4d23_9192_0d3bd29925d5
is: SBO:0000297
initial amount: NaN
has only substance units: false
constant: false
type: Species
has part: Q6FIH7
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
boundary condition: true
is encoded by: hsa:516
initial concentration: NaN

metaM coa n
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
is: CHEBI:57287
type: Species
boundary condition: false
has only substance units: false
constant: false
is: HMDB01423
name: coenzyme A(4-)

metaR UDPDOLPT L
is described by: ECO:0000000
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (liver)
modifier: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.117
product: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:8280060 NOTES:NCD
is: SBO:0000176
reversible: false
type: Reaction

metaM gullac r
is: SBO:0000247
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
initial amount: NaN
boundary condition: false
name: L-gulono-1,4-lactone
type: Species
is: CHEBI:17587
is: HMDB03466

metaM 4hexdtricoa x
type: Species
constant: false
is: HMDB02288
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247
name: 4,7,10-hexadecatrienoylcoa
boundary condition: false

metaR B3GNT35g
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
modifier: MODEL1310110004#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110004#_1e209971_50ea_4fee_b80c_4e6eefe513b5
boundary condition: true
initial amount: NaN
is encoded by: hsa:5293
is: SBO:0000252
type: Species
is: A7E2E0
name: PIK3CD
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_a812fa47_f754_4c61_9c8f_746330e65820
constant: false
boundary condition: true
is encoded by: hsa:6487
type: Species
is: Q11203
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ST3GAL3
is: SBO:0000252

metaM lgnc c
name: lignocerate
is: HMDB02003
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
type: Species
initial concentration: 1.0
is: CHEBI:31014

http://identifiers.org/biomodels.db/MODEL1310110004#_184d6eb0_58f8_4e9a_9577_3444c3a3112e
is: SBO:0000252
initial concentration: NaN
is: A8K092
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:498
name: ATP5A1
constant: false
initial amount: NaN

metaM o2s c
boundary condition: false
is: SBO:0000247
is: HMDB02168
constant: false
has only substance units: false
name: superoxide
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
type: Species
initial amount: NaN
is: CHEBI:18421
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_f831c934_d3b9_43eb_a4a2_1928445e6ec8
name: PMM2
is encoded by: hsa:5373
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is: O15305
type: Species

metaM coa m
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: C00010
is: HMDB01423
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
constant: false
boundary condition: false
initial amount: NaN
name: Coenzyme A
is: CHEBI:57287

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_c8935ee2_79f1_42a9_9686_665bbf37845f
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR SRTNtu
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000269
name: Serotonin uniport
reversible: true
reactant: MODEL1310110004#
type: Reaction
fast: false
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaM cmp m
is: HMDB00095
name: CMP(2-)
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
is: SBO:0000247
is: CHEBI:60377
constant: false
boundary condition: false
has only substance units: false

metaM co2 m
initial concentration: 1.0
is: HMDB01967
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:16526
name: CO2
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: C00011
constant: false
boundary condition: false
has only substance units: false

metaR EX gthox LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxidized glutathione exchange
type: Reaction

metaR r2120
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
reactant: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
kinetic law: MODEL1310110004#

metaM itacon m
name: itaconate(2-)
is: HMDB02092
boundary condition: false
is: CHEBI:17240
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
constant: false
is: SBO:0000247
has only substance units: false

metaR RE1709N
modifier: MODEL1310110004#
name: RE1709
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
kinetic law: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is described by: ECO:0000000

metaM focytC m
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
type: Species
is: CHEBI:16928
initial concentration: 1.0
name: Ferrocytochrome C
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM oxa c
initial amount: NaN
name: oxalate(2-)
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
constant: false
is: CHEBI:30623
boundary condition: false
is: HMDB02329
is: SBO:0000247

metaR UMPtr
is: SBO:0000185
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.7.4.14 Confidence Level: 1 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
is described by: ECO:0000269
name: UMP transport (ER)
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_cac08b43_7321_473b_81ed_4eb5e03d73db
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:5153
boundary condition: true
has only substance units: false
initial amount: NaN
name: PDE1B
is: Q7Z364

metaM etoh e
has only substance units: false
name: ethanol
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00108
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:16236
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469

metaR RE1845X
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
product: MODEL1310110004#
name: RE1845
type: Reaction
modifier: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
is described by: ECO:0000000
reactant: MODEL1310110004#

metaM cmp n
initial amount: NaN
type: Species
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
boundary condition: false
is: SBO:0000247
name: CMP(2-)
is: CHEBI:60377
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00095

metaM pentcoa m
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: pentanoylcoa
is: HMDB13037
constant: false
is: C00888
initial concentration: 1.0
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
type: Species

metaR GLYCTO1p
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
is described by: ECO:0000269
fast: false
name: Glycolate oxidase, peroxisome
modifier: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.1.3.15
type: Reaction
kinetic law: MODEL1310110004#
reversible: false

metaR NAt3 1
product: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
is: SBO:0000185
reversible: true
fast: false
name: sodium proton antiporter (H:NA is 1:1)
reactant: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR

metaM ksi deg4 l
is: HMDB00868
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I, degradation product 4
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C222H355N15O197S12 CHARGE: -12
constant: false
is: CHEBI:57737
boundary condition: false

metaR r2121
reversible: true
product: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110004#
type: Reaction
is described by: ECO:0000000

metaR ORNDC
is described by: ECO:0000269
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/4.1.1.17
name: Ornithine Decarboxylase
is: SBO:0000176
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
product: MODEL1310110004#
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
type: Reaction
reversible: false

metaM coa g
is: HMDB01423
name: coenzyme A(4-)
type: Species
is: CHEBI:57287
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

http://identifiers.org/biomodels.db/MODEL1310110004#_e1705711_8b3f_467b_be54_749631f92ee1
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ALDH3A2
is: P51648
is encoded by: hsa:224
is: SBO:0000252
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_aa2ffd81_8472_4bd7_9269_0c61c2a9b182
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
name: PIGA
is encoded by: hsa:5277
initial concentration: NaN

metaR G14T18g
kinetic law: MODEL1310110004#
fast: false
modifier: MODEL1310110004#
type: Reaction
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
reactant: MODEL1310110004#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22

metaM h x
constant: false
boundary condition: false
name: proton
initial amount: NaN
is: C00080
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636

metaR DHORTS
type: Reaction
name: dihydroorotase
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: true
is version of: http://identifiers.org/ec-code/2.1.3.2
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000269
is: SBO:0000176
fast: false

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_f46ff40d_cfa4_4efc_9c01_ebee5e9d8ad8
is: A4D0W4
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10157
boundary condition: true
type: Species
name: AASS
is: SBO:0000252
has only substance units: false

metaM 2maacoa m
initial concentration: 1.0
name: 2-methylacetoacetyl-CoA(4-)
constant: false
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57335
is: HMDB01157
is: SBO:0000247
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344

metaR G6PDH1rer
reversible: true
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.1.1.47
product: MODEL1310110004#
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000176

metaR r1798
is: SBO:0000185
type: Reaction
reversible: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM CE2418 m
is: CHEBI:28387
constant: false
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
is: HMDB11123
type: Species
boundary condition: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaR r2122
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000185
fast: false
product: MODEL1310110004#

metaR r1088
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
fast: false
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110004#

metaM docohepcoa m
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
notes: FORMULA: C43H60N7O17P3S CHARGE: -4

metaR HTDCRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

metaR STRDNCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110004#
reversible: true
fast: false
reactant: MODEL1310110004#
name: fatty acid transport via diffusion
product: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaR MI14PP
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.57
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
reversible: false
type: Reaction
name: inositol-1,4-bisphosphate 1-phosphatase

metaM nadph x
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57783
is: HMDB00221
has only substance units: false
initial amount: NaN
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
type: Species
is: C00005
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005

metaR DM atp c
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
name: DM_atp(c)
reactant: MODEL1310110004#

metaR r2123
is: SBO:0000185
fast: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_f1670cb6_3f39_4cc3_b359_b1b37ff8ad8c
type: Species
is: Q9UBY0
has only substance units: false
is encoded by: hsa:6549
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: SLC9A2

metaM Rtotal2coa c
is: C00055
type: Species
is: HMDB00095
initial concentration: 1.0
boundary condition: false
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
constant: false
is: CHEBI:60377
is: SBO:0000247
name: R total 2 coenzyme A
initial amount: NaN
has only substance units: false

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM gsn c
is: SBO:0000247
is: C00387
is: HMDB00133
type: Species
constant: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
boundary condition: false
has only substance units: false
is: CHEBI:16750
initial amount: NaN
name: Guanosine
initial concentration: 1.0

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

metaR UREAt5
fast: false
product: MODEL1310110004#
name: urea, water cotransport
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_3fc4eba1_9308_473c_80fd_d652053e3903
has only substance units: false
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: E7EX19
is encoded by: hsa:5295
initial amount: NaN
is: SBO:0000252
name: PIK3R1

http://identifiers.org/biomodels.db/MODEL1310110004#_d5bb408d_bb30_4f6b_b338_7c6196af47c4
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000297
has only substance units: false
is encoded by: hsa:4830
initial concentration: NaN
type: Species
has part: P15531
name: NME1:NME2
is encoded by: hsa:4831
has part: P22392

metaR DOPAt4 2 r
fast: false
name: Dopamine reversible transport in via sodium symport (1:2)
is described by: ECO:0000269
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185
reversible: true
product: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110004#_ff527fd3_6748_42ba_a4e8_f76ac103ce42
name: DHFR
is encoded by: hsa:1719
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P00374
type: Species
constant: false

metaR NTD4e
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
reactant: MODEL1310110004#
fast: false
is: SBO:0000176
name: 5'-nucleotidase (CMP), extracellular
reversible: false
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.3.5
is described by: ECO:0000134

metaR NDPK1m
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110004#
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: true
type: Reaction
is: SBO:0000176
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
is described by: ECO:0000254

metaR DECCRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydecanoyl carnitine into extra cellular space
type: Reaction

metaR CERT1rt
reversible: true
modifier: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
name: ceramide transport protein
product: MODEL1310110004#
is: SBO:0000185
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide

metaR 4NPHte
product: MODEL1310110004#
reversible: true
name: xenobiotic transport
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110004#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8385949,PMID:9219629 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Physiological, Rat
reactant: MODEL1310110004#

metaR UDPtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
name: udp intracellular transport
product: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true

metaM ppi m
is: HMDB00250
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: C00013
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:33019
type: Species
name: Diphosphate
is: SBO:0000247

metaM tcynt c
is: CHEBI:18022
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
name: thiocyanate
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
is: HMDB01453

metaM tmndnccoa c
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
is: HMDB06514
name: timnodonyl coenzyme A
boundary condition: false

metaR EX 25hvitd3 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 25-Hydroxyvitamin D3 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_fbb5e75a_712c_46ad_a404_57198ca4cf1d
name: IDH2
has only substance units: false
initial concentration: NaN
is: P48735
is: SBO:0000252
is encoded by: hsa:3418
boundary condition: true
initial amount: NaN
type: Species
constant: false

metaR PRISTCOAtcx
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_7f4da93f_c737_4bcf_9844_783ab3b09796
is: P43353
name: ALDH3B1
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:221

metaM 10fthf6glu e
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:57454
constant: false
is: HMDB00972
name: 10-formyltetrahydrofolate-[Glu](6)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1

metaR GGLUCT
is described by: ECO:0000269
name: gamma-glutamylcyclotransferase
modifier: MODEL1310110004#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
is version of: http://identifiers.org/ec-code/2.3.2.4
is: SBO:0000185
fast: false
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#

metaR MGSA
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
name: methylglyoxal synthase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
reversible: false
fast: false

metaR MI4PP
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.25
name: myo-inositol 4-phosphatase
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110004#

metaM glyc R m
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:16659
name: D-glycerate
is: HMDB00139
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235

http://identifiers.org/biomodels.db/MODEL1310110004#_920863b6_4d6d_4760_bfbf_e54bbf6e16ab
constant: false
boundary condition: true
is: SBO:0000252
name: SLC26A3
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:1811
is: P40879

metaR S6TASE20ly
modifier: MODEL1310110004#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110004#
reactant: MODEL1310110004#
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
kinetic law: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD

metaM ppi n
is: HMDB00250
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
initial concentration: 1.0
boundary condition: false
name: diphosphate(3-)
constant: false
is: CHEBI:33019
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_6aab4b6b_0dd1_430c_95cc_d2d89755bc3a
initial amount: NaN
is: Q13907
name: IDI1
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3422
boundary condition: true

metaR ABTti
is described by: ECO:0000000
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: L-arabinitol transport via passive diffusion
product: MODEL1310110004#
fast: false
type: Reaction
reversible: false
is: SBO:0000185
reactant: MODEL1310110004#

metaM retinal 11 cis c
is: HMDB02152
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: SBO:0000247
initial amount: NaN
is: CHEBI:16066
type: Species
name: 11-cis-retinal
initial concentration: 1.0

metaM dhcholoylcoa x
initial amount: NaN
constant: false
is: HMDB06895
is: CHEBI:27393
boundary condition: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
is: SBO:0000247
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
has only substance units: false
initial concentration: 1.0
type: Species

metaM digalside hs l
type: Species
has only substance units: false
is: C06126
is: http://identifiers.org/pubchem.compound/8383
is: SBO:0000247
boundary condition: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
name: Digalactosylceramide
initial concentration: 1.0
constant: false
initial amount: NaN

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaR r0853
kinetic law: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110004#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
reversible: false
name: Facilitated diffusion
product: MODEL1310110004#

metaR ARACHDt2
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
reversible: true
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185

metaM chtn e
is: CHEBI:17029
name: chitin
constant: false
boundary condition: false
notes: FORMULA: C24H41N3O16 CHARGE: 0 INCHI: InChI=1S/C24H41N3O16/c1-7(31)25-13-18(36)20(11(5-29)39-22(13)38)42-24-15(27-9(3)33)19(37)21(12(6-30)41-24)43-23-14(26-8(2)32)17(35)16(34)10(4-28)40-23/h10-24,28-30,34-38H,4-6H2,1-3H3,(H,25,31)(H,26,32)(H,27,33)/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02118
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB03362

metaM ksi pre31 g
name: keratan sulfate I biosynthesis, precursor 31
has only substance units: false
initial amount: NaN
is: HMDB00175
type: Species
is: CHEBI:58053
is: C00130
is: SBO:0000247
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
constant: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_97b79449_f10f_4e69_9ba8_9bc4eaf6adb6
initial amount: NaN
is encoded by: hsa:1119
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: CHKA
is: P35790
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_d4b24e0f_33c6_48e0_b9f5_5f0640150fe2
constant: false
name: _H17063_1_m
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:H17063
type: Species
initial amount: NaN
boundary condition: true

metaM mi1345p c
is: CHEBI:57895
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
initial concentration: 1.0
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
type: Species
is: HMDB01059
is: SBO:0000247

metaR GLCter
reversible: true
is: SBO:0000185
name: glucose transport, endoplasmic reticulum
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD

metaM chsterol e
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
constant: false
is: HMDB00067
name: cholesterol
initial concentration: 1.0
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1

metaM tcynt e
has only substance units: false
type: Species
is: HMDB01453
initial amount: NaN
name: thiocyanate
boundary condition: false
is: CHEBI:18022
initial concentration: 1.0
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
is: SBO:0000247
constant: false

metaR r0926
kinetic law: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
reversible: false
fast: false
reactant: MODEL1310110004#
product: MODEL1310110004#
name: Postulated transport reaction
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_e35256a5_9592_4abb_8d9c_2eee322496ae
is: SBO:0000252
type: Species
is encoded by: hsa:MBOAT5
name: _MBOAT5_1_c
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false

metaM etoh c
name: ethanol
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
initial amount: NaN
is: HMDB00108
constant: false
initial concentration: 1.0
is: CHEBI:16236
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species

metaM methf c
is: C00445
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: 5,10-Methenyltetrahydrofolate
is: HMDB01354
type: Species
has only substance units: false
is: CHEBI:57455
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445

metaR IDOURte
name: L-iduronate transport, extracellular
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reversible: true
is: SBO:0000185
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_c1639cf1_9fc1_4508_9b3f_bd11174e1438
initial concentration: NaN
type: Species
is: SBO:0000252
is: P09923
is encoded by: hsa:248
name: ALPI
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true

metaR FACOAL150
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
is described by: ECO:0000000
reversible: true
name: fatty-acid--CoA ligase
reactant: MODEL1310110004#
is: SBO:0000176
fast: false
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction

metaR RE1522M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110004#
modifier: MODEL1310110004#
reversible: true
name: RE1522
is: SBO:0000176
kinetic law: MODEL1310110004#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_2a0ceae8_5fe6_4895_a42e_df0cef2d50d2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:54898
constant: false
is: SBO:0000252
type: Species
is: Q9NXB9
name: ELOVL2
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_8b4d3e3e_34cf_4bf5_8caa_f928fc280a0f
initial concentration: NaN
is: SBO:0000252
is: Q15102
type: Species
name: PAFAH1B3
boundary condition: true
has only substance units: false
is encoded by: hsa:5050
initial amount: NaN
constant: false

metaR M16NTg
is described by: ECO:0000000
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110004#
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.143

metaR FAOXC1811603m
modifier: MODEL1310110004#
fast: false
name: Beta oxidation fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110004#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR C142OHe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:2-OH
type: Reaction

metaR r1591
is described by: ECO:0000000
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110004#
fast: false

metaR TETTET6t
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110004#

metaM chsterol c
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: cholesterol
constant: false
is: HMDB00067
is: CHEBI:16113
is: SBO:0000247

metaR LTD4DP
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
fast: false
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110004#
name: Leukotriene D4 dipeptidase

metaR FACOAL170
modifier: MODEL1310110004#
fast: false
is: SBO:0000176
name: fatty-acid--CoA ligase
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110004#
product: MODEL1310110004#

metaM ppi r
type: Species
name: Diphosphate
is: HMDB00250
boundary condition: false
is: C00013
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN

metaR FAOXC102C81x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)x
type: Reaction

metaR EX CE5868 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_551c70b5_9f65_4ce4_b21b_fd21bb3bb543
type: Species
constant: false
has only substance units: false
is encoded by: hsa:1350
initial amount: NaN
boundary condition: true
name: COX7C
is: P15954
is: SBO:0000252
initial concentration: NaN

metaR FAOXC12C10m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->C10)m
type: Reaction

metaR r1590
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110004#
fast: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction

metaM udpglcur c
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
has only substance units: false
name: UDP-D-glucuronate
initial amount: NaN
is: HMDB00935
is: C00167
constant: false
is: SBO:0000247
type: Species
is: CHEBI:58052
initial concentration: 1.0
boundary condition: false

metaM dhcholestancoa x
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
is: HMDB02159
initial concentration: 1.0
type: Species
is: CHEBI:15494
constant: false
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_d80b40b0_89c4_4f0b_ab7a_a329a55edc06
initial amount: NaN
type: Species
is: Q13615
name: MTMR3
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8897
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_c1059818_69a3_49e5_afe0_e6a638b52658
initial amount: NaN
is: Q8IZH9
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:2643
name: GCH1
constant: false
initial concentration: NaN

metaR PRPPS
name: phosphoribosylpyrophosphate synthetase
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
product: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.6.1
reactant: MODEL1310110004#
fast: false

metaM apoC Lys btn m
is: HMDB03134
is: SBO:0000247
boundary condition: false
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C16H27N4O3SX CHARGE: 0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7886
is: C05552

metaR CYTK7n
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110004#
is described by: ECO:0000269
fast: false
type: Reaction
reactant: MODEL1310110004#
name: cytidylate kinase (CMP,UTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
kinetic law: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_38922041_0273_42eb_8b61_4b93e416272d
initial concentration: NaN
is: SBO:0000252
is: Q9H999
type: Species
initial amount: NaN
name: PANK3
has only substance units: false
boundary condition: true
is encoded by: hsa:79646
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_859b7584_16da_460d_b5ff_f6fb6ffa4d76
constant: false
type: Species
is: Q53HE2
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:7167
has only substance units: false
initial amount: NaN
name: TPI1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_a6b0ec27_2554_468e_afc1_516bb860abb3
name: PTGDS
is encoded by: hsa:5730
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: P41222
has only substance units: false

metaM guln r
is: HMDB03290
is: CHEBI:13115
initial concentration: 1.0
constant: false
has only substance units: false
name: L-gulonate
boundary condition: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
initial amount: NaN
is: SBO:0000247
type: Species

metaR ENGASEly
is: SBO:0000176
name: endo-beta-N-acetylglucosaminidase, lysosomal
product: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_galacgalfucgalacglcgal14acglcgalgluside_hs_g
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:26174
initial concentration: 1.0
constant: false
has only substance units: false
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0

metaM HC00822 e
initial concentration: 1.0
boundary condition: false
is: CHEBI:28681
name: Chitobiose
type: Species
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR EICOSTETCRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110004#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110004#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110004#
product: MODEL1310110004#
name: transport into the mitochondria (carnitine)
reversible: false

metaM ficytC m
boundary condition: false
is: CHEBI:15991
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
has only substance units: false
type: Species
name: Ferricytochrome c
constant: false

metaR DHPM2
product: MODEL1310110004#
is described by: ECO:0000000
name: dihydropyrimidinase (dihydrothymine)
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 2 AUTHORS: NOTES:Also acts on dihydrothymine and hydantoin. Found not specific evidence in PubMed, but Dihydropyrimidinase is supposed to be in cytosol and catalyze this reaction. Old information
is: SBO:0000176
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_93e710e8_3765_4ea5_9160_34ddd7349cdb
type: Species
is encoded by: hsa:94005
is: Q8NBL9
name: PIGS
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_8c2db97d_ad98_4d4a_9347_ad3d007e5ff2
is: Q9NUD9
has only substance units: false
constant: false
type: Species
boundary condition: true
is encoded by: hsa:55650
initial amount: NaN
is: SBO:0000252
name: PIGV
initial concentration: NaN

metaM tetdece1coa c
has only substance units: false
name: tetradecenoylcoa
type: Species
boundary condition: false
is: HMDB05066
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
constant: false

metaR S6T11g
reactant: MODEL1310110004#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176

metaM digalside hs c
is: C06126
is: http://identifiers.org/pubchem.compound/8383
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C06126
name: Digalactosylceramide
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR G6PPer
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.3.9
product: MODEL1310110004#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
kinetic law: MODEL1310110004#
is: SBO:0000176
name: glucose-6-phosphate phosphatase, edoplasmic reticular
reactant: MODEL1310110004#

metaR AG13T15g
modifier: MODEL1310110004#
reversible: false
reactant: MODEL1310110004#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110004#_d2413f8d_afd1_4de8_a1fc_1a2e471d95f6
constant: false
is encoded by: hsa:55229
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: PANK4
is: Q9NVE7
has only substance units: false
type: Species

metaR 2MB2COAc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

metaR r1595
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110004#
reversible: true

metaM nrvnccoa x
name: nervonyl coenzyme A
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
is: C16532
constant: false
notes: FORMULA: C45H76N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H80N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h11-12,32-34,38-40,44,55-56H,4-10,13-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b12-11-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_c388fb12_33f5_4950_8b7b_46fe3154817b
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: Q96RN1
type: Species
constant: false
is encoded by: hsa:116369
name: SLC26A8
has only substance units: false

metaR EX c10crn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decanoyl carnitine
type: Reaction

metaM ppi e
is: C00013
name: Diphosphate
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019

http://identifiers.org/biomodels.db/MODEL1310110004#_7357a142_3ae7_486c_96e3_3e43cfe314c8
constant: false
is encoded by: hsa:84002
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q9BYG0
boundary condition: true
name: B3GNT5

metaR AG13T3g
is: SBO:0000176
modifier: MODEL1310110004#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110004#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaM doco13ecoa c
notes: FORMULA: C43H72N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892791
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: 13-docosenoylcoa
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_d3149115_e8b1_4fae_9463_546ae2c80210
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
is encoded by: hsa:498
constant: false
boundary condition: true
initial amount: NaN
has part: P25705
initial concentration: NaN
has part: Q6I9V2
is: SBO:0000297
has only substance units: false
type: Species
is encoded by: hsa:509

metaR DCSPTN1COAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110004#
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
reversible: true
name: fatty acid intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110004#_42ddddd7_e208_4fa3_b2c0_d9499611f589
has only substance units: false
name: _U37519_1_m
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:U37519
type: Species
is: SBO:0000252
constant: false

metaM c12dccoa x
initial amount: NaN
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
type: Species
constant: false
initial concentration: 1.0
is: HMDB03712
has only substance units: false
name: dodecanedioylcoa
boundary condition: false
is: SBO:0000247

metaR PGLYCt
name: phosphatidylglycerol transport
is: SBO:0000185
fast: false
product: MODEL1310110004#
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 3.1.3.18 Confidence Level: 2 AUTHORS: PMID:2164460,PMID:6290284 NOTES:
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction

metaR C3DCe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

metaR r1594
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEtg
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
name: blood group intracellular transport
reactant: MODEL1310110004#
reversible: true
product: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_0c22bb7f_51c7_4a25_be00_5de757741ddb
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: ST3GAL3
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6487
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_15e64481_1092_420e_80ce_2813cfbf8eee
name: NPR2
has only substance units: false
is encoded by: hsa:4882
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is: P20594
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_e36c88b2_19cf_4594_a7a4_f5a5db31a1c9
has part: O95169
is encoded by: hsa:4729
has part: O75438
has part: O75251
is encoded by: hsa:4708
is encoded by: hsa:4726
is encoded by: hsa:4536
has part: P56556
is encoded by: hsa:4705
is encoded by: hsa:4715
is encoded by: hsa:4696
has part: Q16795
has part: Q6IB80
is encoded by: hsa:4698
is encoded by: hsa:126328
has part: Q6IBC4
has part: Q9Y6M9
has part: Q7GXY9
is encoded by: hsa:4706
is encoded by: hsa:55967
is encoded by: hsa:374291
is encoded by: hsa:4538
has part: F8VQS7
is encoded by: hsa:4722
is encoded by: hsa:4713
initial amount: NaN
is encoded by: hsa:4701
is encoded by: hsa:4711
has part: O95167
has part: Q9P0J0
is encoded by: hsa:4709
is encoded by: hsa:4719
has part: O95168
is encoded by: hsa:4716
has part: E5KNH5
is encoded by: hsa:4697
constant: false
has part: O75489
has part: O14561
is encoded by: hsa:4724
has part: O43674
is encoded by: hsa:4540
is encoded by: hsa:4694
has part: O43677
has part: Q549M5
has part: Q85KV6
has part: P56181
is encoded by: hsa:4717
is encoded by: hsa:4539
is: SBO:0000297
type: Species
has part: P03915
has part: Q6FG42
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is encoded by: hsa:4714
has part: P28331
has part: O00217
is encoded by: hsa:4712
has part: Q7GXZ1
has part: P03905
has part: Q16718
has part: O43678
is encoded by: hsa:4720
has part: C9JT23
has part: P19404
is encoded by: hsa:4728
has part: A8K761
has part: P17568
is encoded by: hsa:4707
is encoded by: hsa:4725
is encoded by: hsa:4535
initial concentration: NaN
has part: O43181
is encoded by: hsa:4723
is encoded by: hsa:4704
has part: Q13454
has part: O95299
is encoded by: hsa:4710
is encoded by: hsa:4695
has part: P03897

http://identifiers.org/biomodels.db/MODEL1310110004#_4c43dae1_37a2_4762_8627_9f9fa37840b6
initial amount: NaN
is: SBO:0000252
is: Q92947
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2639
name: GCDH
has only substance units: false

metaM HC02179 e
is: SBO:0000247
has only substance units: false
boundary condition: false
name: 20-hydroxy-arachidonate
initial amount: NaN
type: Species
is: CHEBI:34306
initial concentration: 1.0
constant: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

metaM udpgal g
is: HMDB00302
is: CHEBI:58439
has only substance units: false
initial concentration: 1.0
name: UDP-D-galactose(2-)
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
constant: false
initial amount: NaN

metaM cholp c
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
is: SBO:0000247
is: CHEBI:295975
name: choline phosphate(1-)

http://identifiers.org/biomodels.db/MODEL1310110004#_3f87cf32_87de_4e89_8bf3_b69b248c1815
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7389
is: SBO:0000252
constant: false
is: P06132
has only substance units: false
type: Species
boundary condition: true
name: UROD

metaM 2octdectecoa m
constant: false
is: http://identifiers.org/pubchem.compound/5280355
name: 2,6,9,12-octadecatetraenoylcoa
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_51e24f5c_79e2_45df_ac40_4944984d92d7
is encoded by: hsa:6817
initial amount: NaN
name: SULT1A1
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false

metaR r1593
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000185

metaM chsterol m
type: Species
name: cholesterol
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: HMDB00067
constant: false
initial concentration: 1.0
is: CHEBI:16113
boundary condition: false
has only substance units: false
initial amount: NaN

metaM tcynt m
is: SBO:0000247
name: thiocyanate
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:18022
is: HMDB01453
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_e30b4b0e_25ca_4039_80f3_5585fa238d45
is: P17568
constant: false
is encoded by: hsa:4713
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
name: NDUFB7

metaM tmndnccoa m
name: timnodonyl coenzyme A
is: HMDB06514
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1

metaM apoC Lys btn c
constant: false
initial amount: NaN
notes: FORMULA: C16H27N4O3SX CHARGE: 0
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
type: Species
boundary condition: false
is: CHEBI:32551
is: HMDB00182
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM 5htrp c
initial concentration: 1.0
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
is: SBO:0000247
is: HMDB00472
constant: false
is: CHEBI:17780
name: 5-hydroxy-L-tryptophan
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false

metaR CSNt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185
reactant: MODEL1310110004#
type: Reaction
reversible: true
fast: false
name: cytosine transport via facilated diffusion
is described by: ECO:0000269
product: MODEL1310110004#

metaR ACHtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
reactant: MODEL1310110004#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110004#
is: SBO:0000185
fast: false
name: Acetylcholin transport, nuclear trhough pores
product: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_1bc8a982_caa0_4768_aa93_1122d9afcafa
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: O95299
is encoded by: hsa:4705
is: SBO:0000252
boundary condition: true
name: NDUFA10
constant: false

metaR RE1709C
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
fast: false
name: RE1709
reversible: true

metaR NDP7er
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
fast: false
is described by: ECO:0000000
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
kinetic law: MODEL1310110004#
is: SBO:0000176
reversible: false
product: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEte
name: blood group intracellular transport
type: Reaction
reversible: true
reactant: MODEL1310110004#
product: MODEL1310110004#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
kinetic law: MODEL1310110004#

metaR r1592
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000185
type: Reaction

metaM ppi c
initial concentration: 1.0
constant: false
name: Diphosphate
type: Species
notes: FORMULA: HO7P2 CHARGE: -3
is: CHEBI:0
initial amount: NaN
has only substance units: false
is: C00013
boundary condition: false
is: SBO:0000247
is: HMDB00250

http://identifiers.org/biomodels.db/MODEL1310110004#_ac113157_960a_45bd_8335_3b4efc603e43
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: RDH13
is: SBO:0000252
type: Species
is: B3KVA3
constant: false
is encoded by: hsa:112724

MODEL1310110004#
species: metaM acnacngalgbside hs e
species: metaM hs deg8 l
species: metaM g1m8mpdol U r
species: metaM h l
species: metaM dcsptn1 e
species: metaM HC02216 e
species: metaM fe3 c
type: LocalParameter
species: metaM pa hs n
species: metaM dhcholoylcoa x
species: metaM coa m
species: metaM retn c
species: metaM 3htdcoa c
species: metaM decdicoa c
species: metaM 20ahchsterol m
species: metaM udp c
species: metaM itp c
species: metaM CE1944 c
species: metaM leuktrA4 e
species: metaM gbside hs g
species: metaM HC02205 c
species: metaM o2 x
name: PIK3CB:PIK3R1
species: metaM cmpacna g
species: metaM nadh r
species: metaM aicar c
species: metaM arach c
species: metaM 2dodtricoa m
species: metaM hpdca c
species: metaM amp e
species: metaM dttp n
species: metaM prostgf2 e
species: metaM hdcoa c
species: metaM s7p c
species: metaM lnlncacrn c
species: metaM for e
species: metaM 4mop e
species: metaM 3mob e
species: metaM dcholcoa r
species: metaM dcsptn1coa x
species: metaM dopa e
species: metaM sbt D e
stoichiometry: 3.0
species: metaM btn m
species: metaM tetpent3 e
species: metaM thf m
species: metaM ksi pre1 g
species: metaM pe hs e
species: metaM fprica c
species: metaM succoa m
species: metaM ctp n
species: metaM inost c
species: metaM 2oxoadp m
species: metaM so3 m
species: metaM 4hphac c
species: metaM nrvnc c
species: metaM air c
species: metaM ca2 e
species: metaM 4izp c
species: metaM ru5p D c
species: metaM glyclt x
species: metaM pi c
species: metaM 2mb2coa c
species: metaM triodthy e
species: metaM acglcgalgbside hs g
species: metaM gua e
species: metaM mescoa m
species: metaM m8mpdol U r
stoichiometry: 7.92
species: metaM hexdtrcoa m
species: metaM hom L c
species: metaM CE2432 m
species: metaM galgalgalthcrm hs g
species: metaM cdp n
species: metaM arachd c
species: metaM pyr m
species: metaM 7thf c
species: metaM galacglcgalgbside hs c
species: metaM coa r
species: metaM tym c

http://identifiers.org/biomodels.db/MODEL1310110004#_e0018841_3f74_435d_a487_60470ea36d3a
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: Q8TBF5
name: PIGX
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54965

metaR CRNt
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
modifier: MODEL1310110004#
product: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000269
name: L-carnitine reversible transport

http://identifiers.org/biomodels.db/MODEL1310110004#_d49ec1d1_0288_4e29_bb31_f3e88a1c2826
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: F5H2Y9
constant: false
name: ALDH1A2
is: SBO:0000252
is encoded by: hsa:8854
has only substance units: false

metaM coa x
boundary condition: false
initial amount: NaN
is: C00010
is: SBO:0000247
name: Coenzyme A
type: Species
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
is: HMDB01423
constant: false
initial concentration: 1.0

metaM g1m8masn r
notes: FORMULA: C76H127N2O60X CHARGE: 0
is: C05875
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaM ksi deg38 l
is: HMDB00143
notes: FORMULA: C54H91N3O41 CHARGE: 0
initial amount: NaN
type: Species
name: keratan sulfate I, degradation product 38
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:12936

metaM tetd7ecoa m
boundary condition: false
is: HMDB13109
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
constant: false
name: 7-tetradecenoylcoa
is: SBO:0000247
initial concentration: 1.0

metaR r1599
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110004#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110004#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110004#

metaR DNDPt25m
kinetic law: MODEL1310110004#
is described by: ECO:0000269
modifier: MODEL1310110004#
is: SBO:0000185
reactant: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dTDP transport via dCDP antiport
type: Reaction
product: MODEL1310110004#
fast: false

metaR RE3273C
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:3135804 NOTES:
kinetic law: MODEL1310110004#
name: RE3273
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.4
product: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000

metaR ADAe
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.5.4.4
product: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
is: SBO:0000176
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000269
name: Adenosine deaminase, extracellular
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110004#_41765b0a_44ac_4cf0_9710_c166585b5a46
constant: false
type: Species
boundary condition: true
name: NDUFA3
has only substance units: false
is: O95167
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4696
initial concentration: NaN

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR NADtx
is: SBO:0000185
reversible: true
name: transport of NAD into peroxisome
type: Reaction
reactant: MODEL1310110004#
fast: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134

metaM ksi deg39 l
constant: false
name: keratan sulfate I, degradation product 39
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:12936
notes: FORMULA: C48H81N3O36 CHARGE: 0
initial amount: NaN
is: HMDB00143

metaM chsterol l
type: Species
is: CHEBI:16113
name: cholesterol
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00067
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187

metaR 10FTHFtm
is described by: ECO:0000000
product: MODEL1310110004#
type: Reaction
reversible: true
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
is: SBO:0000185
fast: false

metaM thmpp m
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01372
name: Thiamine diphosphate
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
initial concentration: 1.0
is: CHEBI:45931
constant: false
initial amount: NaN
boundary condition: false

metaR r1598
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110004#
type: Reaction
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110004#

metaM phe L c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: HMDB00159
name: L-phenylalanine
is: CHEBI:17295
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_f1e8bab7_e869_407c_b4c6_c71aae17b2de
is: P00441
initial amount: NaN
boundary condition: true
name: SOD1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6647
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_0a127900_f2d1_4ea4_98dd_9d15dbfd1c43
is: Q5JPH6
name: EARS2
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:124454
initial amount: NaN
initial concentration: NaN

metaM bamppald c
has only substance units: false
is: C05665
initial amount: NaN
type: Species
boundary condition: false
name: beta-Aminopropion aldehyde
constant: false
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
is: HMDB01106
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7975

metaM gal c
is: SBO:0000247
has only substance units: false
name: D-Galactose
constant: false
boundary condition: false
is: C00124
is: HMDB00143
is: CHEBI:0
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0
type: Species
initial amount: NaN

metaR RE1533M
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
fast: false
modifier: MODEL1310110004#
name: RE1533

http://identifiers.org/biomodels.db/MODEL1310110004#_97a4d86f_ef69_4b93_8b0d_4bf9a5fcaa26
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: FTCD
is encoded by: hsa:10841
boundary condition: true
constant: false

metaR FAOXC102C81m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaR FAOXC16080m
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
fast: false
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid

metaR r1597
reversible: true
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000

metaR AACOAT
reversible: true
kinetic law: MODEL1310110004#
name: Acetoacetyl-CoA:acetate CoA-transferase
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.2.1.16
is described by: ECO:0000269
reactant: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
is: SBO:0000176
type: Reaction
modifier: MODEL1310110004#

metaM sbcoa c
is: C02838
initial amount: NaN
is: HMDB00791
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
name: suberylcoa
type: Species
notes: FORMULA: C29H43N7O19P3S CHARGE: -5

metaR URATEt
reactant: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
type: Reaction
name: urate export from cytosol
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
is: SBO:0000185
product: MODEL1310110004#
reversible: false

metaR r1596
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#

metaM phe L e
boundary condition: false
initial concentration: 1.0
is: HMDB00159
is: CHEBI:17295
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
name: L-phenylalanine
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_8a289565_a663_41fc_b3e2_19bead8a2172
name: ND3
initial amount: NaN
is encoded by: hsa:4537
type: Species
is: P03897
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false

metaM HC02179 c
is: CHEBI:34306
boundary condition: false
constant: false
name: 20-hydroxy-arachidonate
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
has only substance units: false
is: SBO:0000247

metaR NACHEX14ly
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_05618da5_8709_490d_a5f8_391ebf6387f8
type: Species
boundary condition: true
name: SLC38A1
initial concentration: NaN
is encoded by: hsa:81539
constant: false
initial amount: NaN
is: Q9H2H9
is: SBO:0000252
has only substance units: false

metaM gal e
constant: false
name: D-Galactose
is: C00124
has only substance units: false
is: HMDB00143
boundary condition: false
is: CHEBI:0
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0
is: SBO:0000247

metaM hs deg1 l
is: SBO:0000247
is: CHEBI:17180
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB01352
constant: false
name: heparan sulfate, degradation product 1
initial concentration: 1.0
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
type: Species

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_371ffff2_7d54_450c_92a3_5b6200c50768
name: PDE1C
initial concentration: NaN
type: Species
is: Q8NB10
is encoded by: hsa:5137
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_5a5d3dce_6d6d_44d7_97d5_7ea14b78ba36
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:9091
is: SBO:0000252
constant: false
boundary condition: true
is: B2RAU6
name: PIGQ
initial concentration: NaN

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaR r0614
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
is described by: ECO:0000000
reversible: true
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
reactant: MODEL1310110004#
fast: false
is: SBO:0000176

metaR AK2LGCHOLt
reversible: true
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:
fast: false
is described by: ECO:0000269
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
reactant: MODEL1310110004#
is: SBO:0000185

metaR N3Tg
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
reactant: MODEL1310110004#
fast: false
is described by: ECO:0000000
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.122
type: Reaction
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110004#_5ba49db9_b798_43b0_b63c_cb275ea8396f
is: Q02221
has only substance units: false
type: Species
is encoded by: hsa:1339
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
name: COX6A2
boundary condition: true

metaR r1576
fast: false
is: SBO:0000185
product: MODEL1310110004#
type: Reaction
reversible: true
kinetic law: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110004#
is described by: ECO:0000000

metaM gdpfuc c
type: Species
constant: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: HMDB01095
name: GDP-L-fucose(2-)
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:57984

metaR LAPCOAe
reactant: MODEL1310110004#
product: MODEL1310110004#
name: LAPCOAe
kinetic law: MODEL1310110004#
is: SBO:0000176
reversible: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA catabolism EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
fast: false

metaR EX octa LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoate (n-C8:0)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_c4e32f6d_90b2_4567_86f5_6a12be606505
is: SBO:0000252
is encoded by: hsa:AL050025
has only substance units: false
name: _AL050025_1_c
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false

metaM arach c
name: arachidate
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB02212
boundary condition: false
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
initial concentration: 1.0
is: CHEBI:32360
constant: false

metaR FAOXC80
product: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reversible: false
modifier: MODEL1310110004#
name: Beta oxidation of med/long chain fatty acid
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110004#

metaR r2139
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is described by: ECO:0000000

metaM c4crn e
boundary condition: false
name: butyryl carnitine
is: C02862
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C11H21NO4 CHARGE: 0
is: http://identifiers.org/pubchem.compound/213144
is: SBO:0000247
is: HMDB02013
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_fccec405_4850_4eb9_88b2_f2f7a7ede2b1
is encoded by: hsa:4726
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: Q6IBC4
constant: false
name: NDUFS6

metaM CE2421 m
name: (3S)-3-hydroxylinoleoyl-CoA
type: Species
is: SBO:0000247
constant: false
is: CHEBI:30623
initial amount: NaN
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB02329

http://identifiers.org/biomodels.db/MODEL1310110004#_2e944ee9_08a3_4a4a_a76e_f25d453a0a79
name: A4GALT
is encoded by: hsa:53947
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: Q9NPC4
is: SBO:0000252
type: Species

metaM oaa m
type: Species
initial amount: NaN
is: HMDB00223
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: C00036
name: Oxaloacetate
constant: false
has only substance units: false
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: CHEBI:16452

http://identifiers.org/biomodels.db/MODEL1310110004#_cf3efede_1248_4938_af8f_2bc7f1084c7a
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
name: LTA4H
type: Species
is: P09960
constant: false
is encoded by: hsa:4048

http://identifiers.org/biomodels.db/MODEL1310110004#_e00bcb20_732a_4137_a202_e1e62df214c6
initial concentration: NaN
is: O00400
initial amount: NaN
is encoded by: hsa:9197
type: Species
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
name: SLC33A1

http://identifiers.org/biomodels.db/MODEL1310110004#_e7766e5a_f456_4ae6_8817_94f35c127a65
has only substance units: false
is encoded by: hsa:1120
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
name: CHKB
boundary condition: true
initial concentration: NaN
is: A0PJM6

metaR r0616
reversible: true
fast: false
product: MODEL1310110004#
is described by: ECO:0000000
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
reactant: MODEL1310110004#
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_9333773d_8eb8_4565_a8b2_5a93ac021f18
boundary condition: true
is encoded by: hsa:2982
is: SBO:0000252
has only substance units: false
name: GUCY1A3
initial amount: NaN
is: D6RDW3
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_f7360bea_88bf_4ba0_a5f6_6769d149ef81
initial amount: NaN
constant: false
initial concentration: NaN
name: ATP8A1
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9Y2Q0
is encoded by: hsa:10396
type: Species

metaM gluside hs r
has only substance units: false
constant: false
initial concentration: 1.0
name: D-glucosyl-N-acylsphingosine
is: CHEBI:18368
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false

metaM leuktrD4 r
type: Species
constant: false
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: CHEBI:28666
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB03080
name: Leukotriene D4
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_679caf11_0bfd_41f8_9560_15627a9a40d5
constant: false
has only substance units: false
is encoded by: hsa:51
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is: Q15067
initial concentration: NaN
name: ACOX1

metaM dcdp c
is: CHEBI:58593
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01245
type: Species
is: C00705
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
name: dCDP

http://identifiers.org/biomodels.db/MODEL1310110004#_8968e1eb_d323_4690_ae6c_86f9b6091a4d
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:NOS2A
initial concentration: NaN
name: _NOS2A_1_e
type: Species

metaM nadh c
name: Nicotinamide adenine dinucleotide - reduced
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/3306
is: CHEBI:57945
type: Species
is: C00004
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01487
constant: false

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaR r2136
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
modifier: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
fast: false
product: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110004#_222477e2_9f63_4f72_a1af_55ac8dc20069
name: _F23536_1_m
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:F23536
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_metaR_EX_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIA glycolipid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_3dd8653f_aeac_404f_84ee_187cbede2669
is encoded by: hsa:2984
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
name: GUCY2C
has only substance units: false
is: P25092
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_c45faecd_7a99_4ce9_814c_3ebdb29cd566
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5052
name: PRDX1
initial concentration: NaN
has only substance units: false
type: Species
constant: false

metaM gbside hs l
initial amount: NaN
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
name: globoside
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:18259
constant: false

metaR THFtm
reactant: MODEL1310110004#
is: SBO:0000185
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
fast: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
is described by: ECO:0000000

metaR FAOXC185m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:5)m
type: Reaction

metaR r1578
fast: false
type: Reaction
product: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaR HSAT1ly
name: heparan-glucosaminide N-acetyltransferase, lysosomal
fast: false
reactant: MODEL1310110004#
is: SBO:0000185
product: MODEL1310110004#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
kinetic law: MODEL1310110004#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_bb6207e5_150c_4162_a5b6_4fe1f9b7d5fd
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:53354
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
name: PANK1

metaR C16DCe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

metaR FOAXC122C101x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_bb0e0625_94f3_4346_9974_0c16bbda3bfa
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
name: NDUFA9
type: Species
initial concentration: NaN
is: Q16795
is encoded by: hsa:4704
initial amount: NaN

metaM arach e
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
name: arachidate
initial concentration: 1.0
is: CHEBI:32360
is: HMDB02212
type: Species
initial amount: NaN
has only substance units: false

metaM c4crn c
is: HMDB02013
boundary condition: false
constant: false
initial amount: NaN
name: butyryl carnitine
has only substance units: false
initial concentration: 1.0
is: C02862
notes: FORMULA: C11H21NO4 CHARGE: 0
type: Species
is: http://identifiers.org/pubchem.compound/213144
is: SBO:0000247

metaR r2137
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
type: Reaction
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
is: SBO:0000185
product: MODEL1310110004#
fast: false
reversible: true
reactant: MODEL1310110004#

metaM retinal cis 9 c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:17898
name: all-trans-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: HMDB01358
type: Species
constant: false
initial amount: NaN

metaR THFtl
reversible: true
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD,IT
is: SBO:0000185
product: MODEL1310110004#
kinetic law: MODEL1310110004#
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, lysosomal
type: Reaction
fast: false
is described by: ECO:0000000

metaR r1579
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_50d54fde_346e_41ec_ad8b_68b66791ef6e
boundary condition: true
name: ADH1B
is: P00325
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:125
constant: false

metaR G5SDym
fast: false
reactant: MODEL1310110004#
name: glutamate-5-semialdehyde dehydrogenase (m)
type: Reaction
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 1.2.1.41 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m TDV: name change from G5SDm
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.41
product: MODEL1310110004#
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110004#_07d45338_f7b1_4e27_9da6_2b7f6ecf164a
initial amount: NaN
initial concentration: NaN
name: VNN3
type: Species
is encoded by: hsa:55350
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

metaR SUCD1m
reversible: true
reactant: MODEL1310110004#
name: succinate dehydrogenase
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
kinetic law: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.5.1
fast: false
modifier: MODEL1310110004#

metaM hs deg4 l
constant: false
name: heparan sulfate, degradation product 4
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:16126

metaR ACCOAC
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaM thmpp c
is: CHEBI:45931
name: Thiamine diphosphate
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB01372
type: Species
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
has only substance units: false
is: C00068
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_5ed88789_4ab9_477b_8a13_646426d22fa0
type: Species
is encoded by: hsa:219
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P30837
name: ALDH1B1
is: SBO:0000252

metaM glyc R c
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:16659
has only substance units: false
is: HMDB00139
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
name: D-glycerate

metaM ach n
is: HMDB00895
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: CHEBI:15355
is: SBO:0000247
name: acetylcholine

metaR r0618
type: Reaction
reversible: true
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
product: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_9fbb28ab_06e7_4a69_a1c9_a8d4a7cecae5
initial amount: NaN
type: Species
name: SLC3A2
is: P08195
is encoded by: hsa:6520
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true

metaM ksi deg5 l
type: Species
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
initial amount: NaN
is: CHEBI:12936
has only substance units: false
is: HMDB00143
is: SBO:0000247
constant: false
boundary condition: false
name: keratan sulfate I, degradation product 5
initial concentration: 1.0

metaM dcsptn1crn c
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
type: Species
name: docosa-4,7,10,13,16-pentaenoyl carnitine
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB06321
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM aicar c
boundary condition: false
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: HMDB01517
has only substance units: false
is: CHEBI:58475
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
is: C04677

http://identifiers.org/biomodels.db/MODEL1310110004#_1ca7e8c1_dadf_45d9_8ec0_07e13f86ea07
boundary condition: true
is: Q9H0N5
initial concentration: NaN
is encoded by: hsa:84105
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: PCBD2

http://identifiers.org/biomodels.db/MODEL1310110004#_569b4322_01f2_4691_a708_d26d3aa4dda3
initial amount: NaN
is: P53004
is encoded by: hsa:644
has only substance units: false
name: BLVRA
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_4c647227_241b_436c_a671_0a6e4ec6e05d
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:55191
constant: false
initial concentration: NaN
boundary condition: true
is: Q6IA69
name: NADSYN1

metaM man c
boundary condition: false
is: HMDB00169
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
type: Species
is: C00159
initial amount: NaN
has only substance units: false
constant: false
name: D-Mannose
is: CHEBI:16024
initial concentration: 1.0

metaM galside hs g
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:12947
name: D-galactosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_2bfff7ce_586e_467f_8cc1_c66725dae744
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: _AI631997_1_m
is encoded by: hsa:AI631997

metaR C16DCc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

metaR DDCRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxydodecanoyl carnitine into extra cellular space
type: Reaction

metaM hgentis c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16169
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
constant: false
has only substance units: false
is: HMDB00130
name: homogentisate
type: Species

metaM ocdcea l
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9- HEPATONET_1.0_ABBREVIATION: HC00510 EHMN_ABBREVIATION: C00712
boundary condition: false
name: oleate
initial concentration: 1.0
is: HMDB00207
constant: false
is: SBO:0000247
type: Species
is: CHEBI:30823
initial amount: NaN

metaR CSNAT2x
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
is described by: ECO:0000269
reactant: MODEL1310110004#
modifier: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.7
type: Reaction
product: MODEL1310110004#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.137
kinetic law: MODEL1310110004#
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
is: SBO:0000176

metaM m6masnB2 g
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:30825
notes: FORMULA: C58H97N2O45X CHARGE: 0
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00573
initial amount: NaN
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

metaM gbside hs g
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:18259
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
name: globoside

http://identifiers.org/biomodels.db/MODEL1310110004#_27070987_8eb7_44fb_a56c_fdf9f424e9f0
type: Species
constant: false
initial concentration: NaN
boundary condition: true
name: TKTL2
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:84076
is: Q9H0I9

http://identifiers.org/biomodels.db/MODEL1310110004#_2c4f2fda_4f78_4b4e_8a60_5073f5e3408f
constant: false
name: OXSM
boundary condition: true
initial amount: NaN
is: Q9NWU1
is encoded by: hsa:54995
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_4f82978e_ecf1_4ae1_b523_917768ad7c4f
name: B3GNT8
is encoded by: hsa:374907
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false

metaM methf m
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial concentration: 1.0
constant: false
name: (6R)-5,10-methenyltetrahydrofolate
type: Species
initial amount: NaN
boundary condition: false
is: HMDB01354
is: SBO:0000247
has only substance units: false
is: CHEBI:57455

http://identifiers.org/biomodels.db/MODEL1310110004#_5cf4024a_2b1f_4f57_ab19_04484628a60a
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P52789
is encoded by: hsa:3099
constant: false
type: Species
initial amount: NaN
name: HK2
is: SBO:0000252

metaM udpgal c
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
is: HMDB00302
boundary condition: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
name: UDP-D-galactose(2-)
initial amount: NaN
is: SBO:0000247
is: CHEBI:58439

metaR FAOXC3DC
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: malonylcoa-->malonylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_d583886e_ce8a_410a_8600_c62a4306ea42
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SLC16A1
constant: false
initial amount: NaN
is encoded by: hsa:6566
type: Species
is: B4DKS0
boundary condition: true

metaR FAOXC163C164Gm
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaM ksii core2 deg5 l
notes: FORMULA: C50H82N4O38SX CHARGE: -1
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:12936
is: HMDB00143
constant: false
type: Species
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 5
boundary condition: false

metaM pyr m
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: http://identifiers.org/pubchem.compound/3324
initial amount: NaN
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:15361
is: HMDB00243
name: pyruvate
is: C00022

http://identifiers.org/biomodels.db/MODEL1310110004#_7e7d0188_006c_4503_9fa4_bcdf8dd73f0d
name: B3GALNT1
constant: false
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:8706
initial concentration: NaN
is: SBO:0000252
is: Q8TDY1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_6463e846_db54_47c5_82e1_ece1b987154e
constant: false
is encoded by: hsa:5333
is: P51178
boundary condition: true
has only substance units: false
is: SBO:0000252
name: PLCD1
initial concentration: NaN
type: Species
initial amount: NaN

metaR FATP1t
reversible: true
product: MODEL1310110004#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (376497.2) or (10999.1) or (376497.1) or (11000.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816,PMID:9878842 NOTES:electroneutral transport NJ
is described by: ECO:0000269
modifier: MODEL1310110004#
name: fatty acid electroneutral transport
kinetic law: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_3fe8cbe3_c9fd_436a_84ea_3b2cc108caa3
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: ATP1A3
boundary condition: true
is encoded by: hsa:478
is: B7Z2T0
type: Species
initial concentration: NaN

metaR PA HStn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110004#
product: MODEL1310110004#
reversible: true
fast: false
kinetic law: MODEL1310110004#
name: phosphatidate transport, nuclear

http://identifiers.org/biomodels.db/MODEL1310110004#_dc5139bd_9f7e_4347_a92a_c917bd20df7f
initial amount: NaN
boundary condition: true
is: Q9P109
is encoded by: hsa:51301
name: GCNT4
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_c6651f9f_7083_41b5_87e9_542e9034d649
name: DHFR
boundary condition: true
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:1719
initial concentration: NaN
is: P00374
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_e40b460f_1767_46a1_95f0_ac7b1871a539
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:341947
initial concentration: NaN
is: Q7Z4L0
type: Species
initial amount: NaN
is: SBO:0000252
name: COX8C

metaR EX sucr LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sucrose exchange
type: Reaction

metaR 5MTHFt
reactant: MODEL1310110004#
is described by: ECO:0000269
fast: false
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
kinetic law: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
modifier: MODEL1310110004#
type: Reaction
reversible: true
is: SBO:0000185

metaR XYLTt
kinetic law: MODEL1310110004#
name: Xylitol transport via passive diffusion
type: Reaction
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
product: MODEL1310110004#
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110004#_ad626a7f_728c_4407_932f_7329aaae8d0e
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P19961
type: Species
name: AMY2B
is encoded by: hsa:280
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_cda87dc9_831c_4d38_80f5_355ef1b2ae57
has only substance units: false
is: SBO:0000252
type: Species
is: Q969K7
name: TMEM54
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:113452
initial concentration: NaN

metaM leuktrF4 c
type: Species
initial concentration: 1.0
is: SBO:0000247
name: leukotriene F4
initial amount: NaN
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
has only substance units: false
is: HMDB06465
constant: false
is: CHEBI:27491
boundary condition: false

metaM dcdp n
type: Species
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: HMDB01245
name: dCDP(3-)
is: CHEBI:58593
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN

metaM sbcoa x
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
constant: false
name: suberylcoa
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
has only substance units: false

metaR r2130
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110004#
product: MODEL1310110004#
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#

metaR DOLPMT3 Uer
is version of: http://identifiers.org/ec-code/2.4.1.260
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110004#
reversible: false
product: MODEL1310110004#
type: Reaction
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reactant: MODEL1310110004#

metaM ptth c
type: Species
is: HMDB03426
is: CHEBI:16753
initial concentration: 1.0
name: pantetheine
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831

metaR r0509
type: Reaction
product: MODEL1310110004#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
fast: false
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
reactant: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#

metaM adpac x
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H8O4 CHARGE: -2
is: HMDB00448
constant: false
name: adipic acid
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_de4d420d_0667_41f9_b8db_d233c54ba93a
constant: false
has only substance units: false
is: Q9H903
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:441024
name: MTHFD2L

metaR APOCFm
product: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
is: SBO:0000176
reversible: false
name: Apocarboxylase formation, mitochondrial
kinetic law: MODEL1310110004#
fast: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_2cf17e40_fc29_4165_ad33_1c6d3c614f52
initial amount: NaN
constant: false
is encoded by: hsa:2589
is: Q10472
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
name: GALNT1

metaR MANtg
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110004#
reversible: false
product: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
name: mannose efflux from Golgi apparatus
is: SBO:0000185

metaR r2131
fast: false
modifier: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
product: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
is: SBO:0000185

metaR FAOXC226m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_6a0109f5_33a5_4786_8566_306ea7897a50
boundary condition: true
is encoded by: hsa:293
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: SLC25A6
type: Species
constant: false
is: Q6I9V5

http://identifiers.org/biomodels.db/MODEL1310110004#_a59ca200_4d75_449d_bc66_ca7d9f1e96c7
is encoded by: hsa:8790
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: FPGT
boundary condition: true
has only substance units: false
is: O14772
initial amount: NaN

metaR PRASCS
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.3.2.6
is: SBO:0000176
modifier: MODEL1310110004#
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaR FUCASE2ly
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.51
type: Reaction
is: SBO:0000176
reactant: MODEL1310110004#
fast: false
reversible: false
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:11870229,PMID:1769200,PMID:2803312,PMID:2983333 NOTES:NCD
name: alpha-fucosidase, lysosomal
kinetic law: MODEL1310110004#
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_a906eb38_705b_4704_b42a_2551a07e31c3
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q16739
type: Species
name: UGCG
is encoded by: hsa:7357

metaR FAOXC200180m
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
reversible: false
reactant: MODEL1310110004#
fast: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
modifier: MODEL1310110004#

metaR UROLACer
reversible: true
type: Reaction
kinetic law: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
name: uronolactonase, endoplasmic reticulum
fast: false
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000

metaR GHMT2r
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.1
is described by: ECO:0000269
modifier: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
reversible: true
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
is: SBO:0000176
name: glycine hydroxymethyltransferase, reversible

metaM gbside hs c
name: globoside
type: Species
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:18259

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

metaR C142OHc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradeca dienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_6c4eadef_2c00_441e_8a70_7240fbedb4a3
is: SBO:0000252
is encoded by: hsa:57835
has only substance units: false
type: Species
name: SLC4A5
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_2940cb73_1ef2_4a50_bf91_0f2054520b4e
has only substance units: false
is: Q53Y83
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: GLA
is encoded by: hsa:2717
is: SBO:0000252
initial amount: NaN

metaR r0909
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
is: SBO:0000185
type: Reaction
name: Transport reaction
product: MODEL1310110004#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false

metaR PRDX
notes: GENE_ASSOCIATION: (8288.1) SUBSYSTEM: Miscellaneous EC Number: 1.11.1.7 Confidence Level: 0 AUTHORS: PMID:10464338 NOTES:RS/TV (6/3/05) Peroxidases can act on a variety of substrates which are oxidized, not just methanol.
is described by: ECO:0000000
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
is: SBO:0000176
product: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.7
name: Peroxidase (multiple substrates)
reactant: MODEL1310110004#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110004#_bf534745_c009_4eb7_9522_4046da01a4ed
constant: false
is: E9PAK4
initial amount: NaN
is encoded by: hsa:200010
has only substance units: false
name: SLC5A9
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species

metaR AHEXASEly
kinetic law: MODEL1310110004#
is: SBO:0000176
type: Reaction
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110004#
reversible: false
modifier: MODEL1310110004#
is described by: ECO:0000000
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD

metaM ade c
is: SBO:0000247
is: C00147
constant: false
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
has only substance units: false
initial amount: NaN
name: Adenine
is: HMDB00034
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:16708

metaR FAOXC121C10x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

metaR RIBt
reversible: true
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110004#
type: Reaction
fast: false
name: ribose transport via diffusion
reactant: MODEL1310110004#
is: SBO:0000185

metaR ACGBGBSIDEtg
fast: false
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is described by: ECO:0000000
is: SBO:0000185
name: acgbgbside hs intracellular transport
reversible: true

metaM HC00460 c
name: 2,5-dihydroxybenzoate
constant: false
has only substance units: false
is: CHEBI:58044
initial concentration: 1.0
type: Species
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_786b72cd_5601_4239_82a2_9a7018ef2bca
is encoded by: hsa:517
initial concentration: NaN
is: SBO:0000297
has part: F8W7V3
type: Species
constant: false
is encoded by: hsa:9551
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
boundary condition: true
initial amount: NaN

metaM gbside hs e
initial amount: NaN
has only substance units: false
is: CHEBI:18259
type: Species
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
is: SBO:0000247
boundary condition: false
name: globoside
constant: false
initial concentration: 1.0

metaR BTNPLm
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.3.4.10
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
product: MODEL1310110004#
fast: false
reversible: false
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial

metaM dcdp m
is: CHEBI:58593
is: SBO:0000247
constant: false
is: HMDB01245
initial concentration: 1.0
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
type: Species
initial amount: NaN
name: dCDP(3-)
has only substance units: false
boundary condition: false

metaR ABUTt2r
reactant: MODEL1310110004#
fast: false
modifier: MODEL1310110004#
reversible: true
product: MODEL1310110004#
name: 4-aminobutyrate reversible transport in via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
type: Reaction
is described by: ECO:0000304
kinetic law: MODEL1310110004#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110004#_71f12cda_818d_4491_a67f_f70c171d518e
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is: B4DDW0
has only substance units: false
is encoded by: hsa:51109
constant: false
name: RDH11

metaR FAOXC16DCr
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaR r0908
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
name: Postulated transport reaction
type: Reaction
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaM zymstnl r
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:16608
is: HMDB06841
type: Species
name: 5alpha-cholest-8-en-3beta-ol
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_04eae841_adfd_4f65_83df_86a0936ff159
type: Species
is encoded by: hsa:4718
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: Q549M5
name: NDUFC2

metaR ADPCOACROT
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoyl carnitine
type: Reaction

metaR B3GNT36g
type: Reaction
reactant: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reversible: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is described by: ECO:0000269
modifier: MODEL1310110004#

metaM pyr x
initial amount: NaN
is: HMDB00243
boundary condition: false
name: pyruvate
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3324
is: CHEBI:15361
is: C00022
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022

http://identifiers.org/biomodels.db/MODEL1310110004#_3ea6fc23_8d2d_4e55_bc9c_6d1811dbf2d7
is encoded by: hsa:3098
initial concentration: NaN
has only substance units: false
is: A8K7J7
type: Species
name: HK1
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaR ORETNtn
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
name: 4-oxo-retinoic acid transport, Nuclear

http://identifiers.org/biomodels.db/MODEL1310110004#_72341a92_e6a2_4790_aead_52a99ede03a8
is: B2R6S5
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: CMPK1
type: Species
initial amount: NaN
is encoded by: hsa:51727
constant: false

metaM gluside hs g
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:18368
initial amount: NaN
name: D-glucosyl-N-acylsphingosine
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false
boundary condition: false
type: Species

metaR RE1517M
name: RE1517
fast: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
type: Reaction
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
product: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#

metaR GALK
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110004#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.1.157
is version of: http://identifiers.org/ec-code/2.7.1.6
kinetic law: MODEL1310110004#
name: galactokinase
modifier: MODEL1310110004#

metaM l2n2m2mn l
type: Species
is: CHEBI:12936
notes: FORMULA: C54H91N3O41 CHARGE: 0
constant: false
is: HMDB00143
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_fd0e6c73_f56d_47ad_bf2e_4e18740bdce3
has only substance units: false
constant: false
name: GSTZ1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:2954

http://identifiers.org/biomodels.db/MODEL1310110004#_0499adfb_8faa_49ee_95ad_88fac53ce7a9
type: Species
is encoded by: hsa:23305
is: SBO:0000252
initial amount: NaN
name: ACSL6
has only substance units: false
boundary condition: true
is: B2RB13
initial concentration: NaN
constant: false

metaM ade e
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: SBO:0000247
name: adenine
constant: false
type: Species
initial amount: NaN
is: CHEBI:16708
is: HMDB00034
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM xan c
is: CHEBI:17712
has only substance units: false
initial concentration: 1.0
is: HMDB00292
name: Xanthine
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
initial amount: NaN
is: C00385
boundary condition: false

metaR GLUPROASCT1
product: MODEL1310110004#
fast: false
name: glutamate intake by system ASCT-1 transporter
kinetic law: MODEL1310110004#
is: SBO:0000185
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
reactant: MODEL1310110004#
reversible: false
is described by: ECO:0000134
type: Reaction

metaM HC01842 c
boundary condition: false
name: Phosphodimethylethanolamine
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:31997
type: Species
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)

metaR PROSTGE2t2
reversible: true
is described by: ECO:0000269
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110004#
name: prostaglandin uniport
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000185
modifier: MODEL1310110004#
type: Reaction

metaR GALGALGALTHCRMtg
name: galgalgalthcrm hs intracellular transport
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
reversible: true
kinetic law: MODEL1310110004#
is described by: ECO:0000000
product: MODEL1310110004#
is: SBO:0000185
fast: false
type: Reaction

metaR ACGBGBSIDEtl
reactant: MODEL1310110004#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
is: SBO:0000185
name: acgbgbside hs intracellular transport
reversible: true

metaR EX ddece1crn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecenoyl carnitine
type: Reaction

metaR G14T17g
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
is: SBO:0000176
fast: false
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110004#_0523f696_1ea1_444d_94f3_a26ede760f31
is: Q9BZX2
is encoded by: hsa:7371
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: UCK2

metaR r0504
modifier: MODEL1310110004#
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
reversible: true
product: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.3.10
fast: false
reactant: MODEL1310110004#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110004#_50662b54_8762_4a09_bd66_6933c4473791
is: Q96E98
is encoded by: hsa:6005
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
has only substance units: false
name: RHAG
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_2840fa19_328f_4c27_8ef1_de2ca9efe18e
constant: false
boundary condition: true
name: COX7A2
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1347
is: H0UI06
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_e35d50f2_ac1e_4d06_9426_a37599e907c0
initial amount: NaN
initial concentration: NaN
is: O76082
type: Species
has only substance units: false
boundary condition: true
constant: false
name: SLC22A5
is encoded by: hsa:6584
is: SBO:0000252

metaR DHFtm
reversible: true
type: Reaction
kinetic law: MODEL1310110004#
is: SBO:0000185
reactant: MODEL1310110004#
name: dihydrofolate reversible mitochondrial transport
is described by: ECO:0000000
product: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD

metaM thm c
has only substance units: false
name: Thiamin
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00235
is: CHEBI:0
notes: FORMULA: C12H17N4OS CHARGE: 1
initial concentration: 1.0
is: SBO:0000247
is: C00378

http://identifiers.org/biomodels.db/MODEL1310110004#_11065223_a373_4d42_8d3a_69be2b3bdade
initial amount: NaN
has only substance units: false
type: Species
constant: false
boundary condition: true
is encoded by: hsa:1717
is: Q9UBM7
is: SBO:0000252
name: DHCR7
initial concentration: NaN

metaR r2132
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
reactant: MODEL1310110004#
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
product: MODEL1310110004#

metaM hs deg25 l
notes: FORMULA: C23H37O21 CHARGE: -1
is: CHEBI:16126
initial amount: NaN
constant: false
boundary condition: false
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_e1d193ab_5848_42e3_8160_6c293e540032
boundary condition: true
constant: false
has part: B3KT19
is encoded by: hsa:5291
type: Species
initial concentration: NaN
has part: B4DER4
has only substance units: false
is: SBO:0000297
is encoded by: hsa:5295
name: PIK3CB:PIK3R1
initial amount: NaN

metaR EX 3tdcrn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-tetradecanoyl carnitine
type: Reaction

metaM leuktrF4 e
is: HMDB06465
initial amount: NaN
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
type: Species
name: leukotriene F4
is: CHEBI:27491
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false

metaR LEUt4
modifier: MODEL1310110004#
reversible: false
name: L-leucine transport in via sodium symport
product: MODEL1310110004#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (81539.1) or (84889.1) or (6520.1) or (6542.1) or (6541.1) or (11254.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10391915,PMID:10891391,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:1376926,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
kinetic law: MODEL1310110004#
is: SBO:0000185
fast: false
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_92d10eca_a500_4d3e_9201_0b11926f4f5d
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: _T83654_1_m
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:T83654
has only substance units: false

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaM c12dc c
constant: false
notes: FORMULA: C19H34NO6 CHARGE: -1
is: SBO:0000247
boundary condition: false
type: Species
name: dodecanedioyl carnitine
is: HMDB00623
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaM galside hs l
name: D-galactosyl-N-acylsphingosine
initial amount: NaN
is: SBO:0000247
is: CHEBI:12947
has only substance units: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
constant: false
type: Species
boundary condition: false
initial concentration: 1.0

metaR ADPACDAc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of adipic acid for formation of adipoyl carnitine
type: Reaction

metaR GLCAASE9ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
name: beta-glucuronidase, lysosomal
reactant: MODEL1310110004#
is: SBO:0000176
fast: false
is described by: ECO:0000269
product: MODEL1310110004#
reversible: false
modifier: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.31

metaM ocdcea r
constant: false
has only substance units: false
type: Species
is: C00712
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H33O2 CHARGE: -1
name: octadecenoate (n-C18:1)
is: HMDB00207
is: SBO:0000247
is: CHEBI:0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_e5787b3a_e719_4079_b3c5_a8eae91a916a
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:25902
name: MTHFD1L
constant: false
boundary condition: true
type: Species
is: B2RD24

http://identifiers.org/biomodels.db/MODEL1310110004#_74c7779d_17ff_4393_85e5_15256c1f06c4
is encoded by: hsa:AI971023
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
name: _AI971023_1_c
type: Species
has only substance units: false

metaR GALGALGALTHCRMte
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
product: MODEL1310110004#
name: galgalgalthcrm hs transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is described by: ECO:0000000
fast: false

metaM gacpail hs r
is: SBO:0000247
is: CHEBI:61548
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
has only substance units: false
is: HMDB01401
boundary condition: false
name: glucosaminyl-acylphosphatidylinositol
constant: false
initial concentration: 1.0
is: C00092
type: Species

metaR LNELDCCRNt
name: transport into the mitochondria (carnitine)
is: SBO:0000185
modifier: MODEL1310110004#
reversible: false
type: Reaction
product: MODEL1310110004#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR r2133
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110004#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110004#
modifier: MODEL1310110004#

metaR HISTAtu
is: SBO:0000185
kinetic law: MODEL1310110004#
name: Histamine uniport
reversible: true
reactant: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

http://identifiers.org/biomodels.db/MODEL1310110004#_90f5ee6c_d29a_4d55_b52f_a8f3bf157702
is: O75438
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: NDUFB1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4707
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_8e3144e3_e099_4ade_802f_321f5525be7f
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:286016
name: TPI1P2
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaR MI1P Dtn
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
fast: false
name: inositol 1-phosphate nuclear transport (diffusion)
kinetic law: MODEL1310110004#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110004#_f6805860_df4b_434a_ba7a_60d36c7214c0
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:AI345944
name: _AI345944_1_m
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR PROt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reactant: MODEL1310110004#
name: L-proline reversible transport via proton symport
modifier: MODEL1310110004#
is: SBO:0000185
reversible: true
is described by: ECO:0000304
fast: false
kinetic law: MODEL1310110004#
type: Reaction
product: MODEL1310110004#

metaM m8mpdol U r
constant: false
type: Species
is: CHEBI:59093
initial amount: NaN
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_5fcb485c_1c86_4dae_a937_3fd422e253a4
initial amount: NaN
name: HADH
is: Q16836
constant: false
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:3033
initial concentration: NaN
is: SBO:0000252

metaR NDPK4
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:dTDP)
type: Reaction
reversible: true
kinetic law: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is described by: ECO:0000269
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110004#

metaM clpnd c
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
name: clupanodonic acid
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: CHEBI:53488
is: HMDB06528
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR NDP10ex
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
fast: false
reactant: MODEL1310110004#
is: SBO:0000176
name: nucleoside-diphosphatase (IDP), extracellular
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.6.1.6
reversible: false
product: MODEL1310110004#

metaM pro L c
type: Species
is: CHEBI:17203
name: L-proline
is: HMDB00162
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
initial amount: NaN

metaR HMGLm
modifier: MODEL1310110004#
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000134
name: hydroxymethylglutaryl-CoA lyase
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
fast: false
is version of: http://identifiers.org/ec-code/4.1.3.4
type: Reaction
reactant: MODEL1310110004#

metaR r0841
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.271
type: Reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
modifier: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true
name: Free diffusion
product: MODEL1310110004#
is: SBO:0000185

metaR NADtpu
is described by: ECO:0000000
reversible: false
name: NAD transporter, peroxisome
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
fast: false
kinetic law: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
reactant: MODEL1310110004#

metaR FACOAL161
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110004#
reversible: true
product: MODEL1310110004#
is: SBO:0000176
name: fatty-acid--CoA ligase (hexadecenoate)
kinetic law: MODEL1310110004#

metaM dcsptn1coa x
constant: false
type: Species
is: C16173
is: HMDB06513
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205483
initial concentration: 1.0
boundary condition: false

metaM leuktrD4 c
name: Leukotriene D4
is: CHEBI:28666
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: HMDB03080
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
has only substance units: false

metaM coa e
type: Species
constant: false
is: C00010
is: SBO:0000247
initial concentration: 1.0
is: HMDB01423
has only substance units: false
name: Coenzyme A
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
initial amount: NaN
is: CHEBI:57287

metaR GAO1g
is described by: ECO:0000269
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
is: SBO:0000176
product: MODEL1310110004#
modifier: MODEL1310110004#
name: Ganglioside O-acetylation
type: Reaction
kinetic law: MODEL1310110004#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110004#_1d166bef_b5bb_491e_a16f_a8912344d5c3
name: LDHA:LDHB
boundary condition: true
has only substance units: false
initial amount: NaN
has part: P07195
constant: false
is: SBO:0000297
is encoded by: hsa:3945
initial concentration: NaN
type: Species
has part: P00338
is encoded by: hsa:3939

metaM nadh r
initial amount: NaN
type: Species
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:57945
is: HMDB01487
boundary condition: false
name: NADH(2-)
constant: false

metaR CYSGLUexR
is described by: ECO:0000304
kinetic law: MODEL1310110004#
is: SBO:0000185
modifier: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
name: L-cysteine/L-glutamine reversible exchanger
reversible: true

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_875d6ee6_40f2_4e8c_b5bc_777a30ff2207
name: ENTPD8
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:377841
initial concentration: NaN
is: Q5MY95
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_755563b7_8d20_462a_a5fe_65c883266dc0
is encoded by: hsa:8560
constant: false
name: DEGS1
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is: O15121
has only substance units: false
boundary condition: true

metaR NDPK3
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:CDP)
reversible: true
reactant: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110004#
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_f076a548_079c_40c2_ae91_04a0897ac25d
initial concentration: NaN
constant: false
is encoded by: hsa:376497
name: SLC27A1
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false

metaM cholcoads x
is: CHEBI:27505
constant: false
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
type: Species
boundary condition: false
is: HMDB06889
has only substance units: false

metaR r0842
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185
name: Postulated transport reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction

metaR FAOXC161802m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
reversible: false
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
name: Beta oxidation fatty acid

http://identifiers.org/biomodels.db/MODEL1310110004#_b598c74b_45ea_47ed_86d5_21f9e0998dd4
constant: false
is encoded by: hsa:128869
has part: Q8NBL9
has part: O43292
is encoded by: hsa:94005
has only substance units: false
boundary condition: true
is: SBO:0000297
initial amount: NaN
name: PIGK:PIGU:PIGT:GPAA1:PIGS
has part: Q9H490
initial concentration: NaN
is encoded by: hsa:10026
is encoded by: hsa:51604
has part: Q969N2
is encoded by: hsa:8733
type: Species
has part: Q92643

metaR r0915
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110004#
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
fast: false
is described by: ECO:0000000

metaM 5dhf e
type: Species
constant: false
initial concentration: 1.0
is: HMDB06487
initial amount: NaN
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
name: pentaglutamyl folate (DHF)
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM dgsn e
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: C00330
is: CHEBI:17172
boundary condition: false
has only substance units: false
name: Deoxyguanosine
is: SBO:0000247
is: HMDB00085

metaM gluside hs c
initial concentration: 1.0
name: D-glucosyl-N-acylsphingosine
type: Species
is: CHEBI:18368
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false

metaR UDPDOLPT U
modifier: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.117
kinetic law: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
reactant: MODEL1310110004#
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_9a308e08_720d_4b2a_ab93_e91c41b69463
boundary condition: true
name: HCST
is encoded by: hsa:10870
type: Species
initial concentration: NaN
has only substance units: false
is: Q9UBK5
initial amount: NaN
constant: false
is: SBO:0000252

metaR r0502
kinetic law: MODEL1310110004#
reversible: true
type: Reaction
is described by: ECO:0000000
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.113
modifier: MODEL1310110004#
fast: false
product: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110004#_e438251c_72ca_41f1_a840_0778f578bb4e
is: Q53TV9
initial amount: NaN
type: Species
name: RPE
initial concentration: NaN
is encoded by: hsa:6120
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false

metaR UGCG
reactant: MODEL1310110004#
type: Reaction
reversible: false
modifier: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110004#
fast: false
name: Ceramide glucosyltransferase
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.80

metaM clpnd e
boundary condition: false
name: clupanodonic acid
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:53488
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1S/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-21H2,1H3,(H,23,24)/b4-3-,7-6-,10-9-,13-12-,16-15-
constant: false
initial concentration: 1.0
is: HMDB06528
initial amount: NaN

metaR NDPK6
modifier: MODEL1310110004#
type: Reaction
is described by: ECO:0000269
reversible: true
fast: false
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
name: Nucleoside-diphosphate kinase (ATP:dUDP)
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176

metaR G14T16g
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110004#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaR OCDCAtr
is: SBO:0000185
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
type: Reaction
product: MODEL1310110004#
is described by: ECO:0000000
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_f706804e_cd18_4829_845e_e3abe690f202
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: DUT
is encoded by: hsa:1854
type: Species
initial amount: NaN
boundary condition: true
is: P33316

http://identifiers.org/biomodels.db/MODEL1310110004#_de3fed27_451f_4c00_81cc_78f77268108b
constant: false
type: Species
name: NDUFA8
is: B1AM93
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:4702

metaR FRDPtr
fast: false
reactant: MODEL1310110004#
name: lipid, flip-flop intracellular transport
product: MODEL1310110004#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
kinetic law: MODEL1310110004#

metaM coa c
initial amount: NaN
is: CHEBI:3312
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: Coenzyme A
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
is: C00010
is: HMDB01423
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_89badcab_4b72_42f6_9355_4516c3106c13
is encoded by: hsa:4700
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is: P56556
type: Species
has only substance units: false
initial amount: NaN
name: NDUFA6

metaM man r
is: HMDB00169
is: CHEBI:16024
initial concentration: 1.0
name: D-mannose
boundary condition: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_2c10acc9_5d95_4e2d_8717_83265173015d
type: Species
constant: false
boundary condition: true
is encoded by: hsa:AA977580
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: _AA977580_1_c

metaR NDPK5
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110004#
reversible: true
name: Nucleoside-diphosphate kinase (ATP:dGDP)
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000269

metaM pram c
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
is: SBO:0000247
name: 5-Phospho-beta-D-ribosylamine
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:58681
is: HMDB01128
is: C03090

metaR RE1521M
product: MODEL1310110004#
is: SBO:0000176
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1521
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR r0913
fast: false
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110004#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110004#

metaR CREATt4 2 r
product: MODEL1310110004#
name: Creatine transport (sodium symport) (2:1)
reversible: true
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110004#
is: SBO:0000185
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false

metaM Ssq23epx r
type: Species
initial concentration: 1.0
is: CHEBI:15441
name: (S)-2,3-epoxysqualene
has only substance units: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
constant: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB01188

metaR TMDK1m
reactant: MODEL1310110004#
is described by: ECO:0000269
kinetic law: MODEL1310110004#
name: thymidine kinase (ATP:thymidine)
type: Reaction
product: MODEL1310110004#
fast: false
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.1.21
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:9342341 NOTES:TV

metaR MMMm
kinetic law: MODEL1310110004#
reversible: true
is version of: http://identifiers.org/ec-code/5.4.99.2
reactant: MODEL1310110004#
is: SBO:0000176
name: methylmalonyl-CoA mutase
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110004#_a128889c_ee1e_4ce1_8dda_7b318d4d3c1a
is encoded by: hsa:126328
initial amount: NaN
constant: false
is: SBO:0000252
is: C9JT23
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: NDUFA11

metaM m8masn r
is: SBO:0000247
notes: FORMULA: C70H117N2O55X CHARGE: 0
is: C05876
has only substance units: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0

metaR NDPK8
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
fast: false
type: Reaction
name: Nucleoside-diphosphate kinase (ATP:dADP)
reversible: true
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000269
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_6c09a740_b3dc_4cfd_a21e_9979698c6c80
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is: P78381
initial amount: NaN
type: Species
name: SLC35A2
has only substance units: false
is encoded by: hsa:7355

http://identifiers.org/biomodels.db/MODEL1310110004#_3a62cfb9_33cb_462d_9429_20cae67fe80a
initial amount: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
name: _R06874_1_r
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:R06874

metaM arachdcoa m
is: SBO:0000247
is: CHEBI:57368
name: arachidonoyl-CoA(4-)
is: HMDB06523
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
type: Species

metaR H2Otly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110004#
is: SBO:0000185
reversible: true
product: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
name: H2O transport, lysosomal

metaR FAOXC140
type: Reaction
reactant: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110004#
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
product: MODEL1310110004#
is described by: ECO:0000269
modifier: MODEL1310110004#

metaR AG13T2g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110004#
is described by: ECO:0000000
modifier: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#

metaR GALT
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
name: galactose-1-phosphate uridylyltransferase
type: Reaction
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.12
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
product: MODEL1310110004#
is: SBO:0000176

metaR GALt4
modifier: MODEL1310110004#
reversible: true
name: galactose transport via sodium symport
kinetic law: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
fast: false
is described by: ECO:0000269
product: MODEL1310110004#
is: SBO:0000185

metaM gal1p c
is: HMDB00645
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:58336
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3+,4+,5-,6-/m1/s1 EHMN_ABBREVIATION: C00446
has only substance units: false
name: (2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphate
constant: false
boundary condition: false
is: SBO:0000247

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR NDPK7
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
kinetic law: MODEL1310110004#
fast: false
name: nucleoside-diphosphate kinase (ATP:dCDP)
reactant: MODEL1310110004#
modifier: MODEL1310110004#
reversible: true
is: SBO:0000176
type: Reaction

metaR MMSAD3m
type: Reaction
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.2.1.27
fast: false
product: MODEL1310110004#
reversible: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110004#

metaR HOCDACBP
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxyoctadecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM retinol cis 11 c
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB06216
name: 11-cis-retinol
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: CHEBI:16302
type: Species

metaM dad 2 c
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: 2-deoxyadenosine
constant: false
boundary condition: false
is: HMDB00101
is: CHEBI:17256
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
is: SBO:0000247

metaM ala L m
name: L-alanine
type: Species
initial concentration: 1.0
is: HMDB00161
initial amount: NaN
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:16977
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048

http://identifiers.org/biomodels.db/MODEL1310110004#_d41f0847_b7e8_4a65_97d0_8c7734d62ffb
initial amount: NaN
initial concentration: NaN
name: _AI653169_1_c
type: Species
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:AI653169

metaR FACOAL184
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
modifier: MODEL1310110004#
type: Reaction
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110004#
is: SBO:0000176
name: fatty-acid--CoA ligase
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaM nadh m
type: Species
is: HMDB01487
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57945
constant: false
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
boundary condition: false
is: http://identifiers.org/pubchem.compound/3306
is: SBO:0000247

metaR DNDPt17m
name: dUDP transport via dCDP antiport
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
kinetic law: MODEL1310110004#
reversible: false
is: SBO:0000185
modifier: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
fast: false

metaR PGDI
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.18
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
type: Reaction
name: Prostaglandin-H2 D-isomerase [Precursor]
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
is version of: http://identifiers.org/ec-code/5.3.99.2
is described by: ECO:0000269
reactant: MODEL1310110004#
modifier: MODEL1310110004#
reversible: true

metaR OAGD3te
reversible: true
kinetic law: MODEL1310110004#
product: MODEL1310110004#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is: SBO:0000185
name: oagd3 hs transport
type: Reaction
reactant: MODEL1310110004#

metaR C204CRNt
kinetic law: MODEL1310110004#
fast: false
name: arachidonic acid transport into the mitochondria
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
type: Reaction
reversible: false
reactant: MODEL1310110004#
product: MODEL1310110004#

metaM pro L e
is: HMDB00162
constant: false
name: L-proline
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
type: Species
is: CHEBI:17203
has only substance units: false
initial concentration: 1.0

metaM mi4p D c
type: Species
initial concentration: 1.0
is: HMDB01313
has only substance units: false
name: 1D-myo-inositol 4-phosphate(2-)
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3-,4+,5-,6-/m0/s1
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:58469
initial amount: NaN

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaM c12dccoa c
initial concentration: 1.0
is: SBO:0000247
is: HMDB00623
initial amount: NaN
constant: false
type: Species
has only substance units: false
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
boundary condition: false
name: dodecanedioylcoa

metaR CYTK8n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110004#
type: Reaction
reversible: true
kinetic law: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#
name: cytidylate kinase (CMP,dATP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110004#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110004#_51c2bcb1_9f83_49a4_9a50_746e1b423d9e
boundary condition: true
is: SBO:0000252
is encoded by: hsa:80347
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is: Q13057
has only substance units: false
name: COASY

http://identifiers.org/biomodels.db/MODEL1310110004#_0cd4fafe_2c5e_47bb_b084_80e9730d31da
is: Q8IZV5
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:157506
name: RDH10
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_b6c2cd01_ece8_47fc_8845_e2c77b5ae3ff
initial concentration: NaN
initial amount: NaN
is: E7EPT3
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:501
name: ALDH7A1
boundary condition: true
type: Species

metaM leuktrD4 e
is: HMDB03080
has only substance units: false
initial amount: NaN
name: Leukotriene D4
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: CHEBI:28666
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_64f57892_9234_47bd_bd2a_752e2a6f2909
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4258
is: D6RBB5
type: Species
is: SBO:0000252
has only substance units: false
name: MGST2
boundary condition: true
constant: false

metaM oaa c
is: HMDB00223
initial amount: NaN
notes: FORMULA: C4H2O5 CHARGE: -2
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: C00036
is: CHEBI:3338
name: Oxaloacetate
is: SBO:0000247
has only substance units: false

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaR NDPK9
is described by: ECO:0000269
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
name: nucleoside-diphosphate kinase (ATP:IDP)
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110004#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_2f3256ef_7593_4d4d_8b78_942deb08acc5
is encoded by: hsa:80201
name: HKDC1
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is: B3KT70
boundary condition: true

metaM dad 2 e
type: Species
initial concentration: 1.0
constant: false
name: 2-deoxyadenosine
is: HMDB00101
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:17256
initial amount: NaN
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431

metaR C50CPT1
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

metaR FAOXC8C6m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_94f4cf49_9f77_44aa_b178_03f5080b753f
has only substance units: false
is: Q71UM8
is encoded by: hsa:108
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: ADCY2
boundary condition: true

metaR r0917
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
product: MODEL1310110004#
is: SBO:0000185
reactant: MODEL1310110004#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_fe9dff83_23ef_4494_a760_9d40c09c86ff
is encoded by: hsa:124
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: P07327
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ADH1A

metaR HOCTDACBP
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyoctadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaM leuktrA4 c
name: leukotriene A4(1-)
initial concentration: 1.0
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: HMDB01337
is: CHEBI:57463
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_f553e1e7_c62f_48e1_8ade_c1db39feb4f9
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
name: CAD
is encoded by: hsa:790
initial amount: NaN
is: P27708
initial concentration: NaN
constant: false

metaR OAGD3tg
reversible: true
is described by: ECO:0000000
is: SBO:0000185
fast: false
name: oagd3 hs intracellular transport
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
type: Reaction
reactant: MODEL1310110004#

metaR r1581
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110004#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110004#
reactant: MODEL1310110004#
fast: false

metaM Lcystin c
boundary condition: false
constant: false
type: Species
is: HMDB00192
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16283
name: L-cystine
is: SBO:0000247

metaR AG13T16g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110004#

metaR DNDPt24m
name: dTDP transport via dADP antiport
reversible: false
modifier: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#

metaR DCSPTN1CRNt
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
reversible: false
fast: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#

metaM ppa c
is: CHEBI:17272
initial amount: NaN
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
has only substance units: false
name: propionate
is: SBO:0000247
type: Species
is: HMDB00237
initial concentration: 1.0
boundary condition: false

metaM ps hs m
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
name: ps_hs[m]
is: CHEBI:18303

http://identifiers.org/biomodels.db/MODEL1310110004#_a30f93bc_b5e3_44a5_9e59_3d3c83503bed
is encoded by: hsa:115111
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: SLC26A7
boundary condition: true
constant: false
is: SBO:0000252
type: Species

metaM galside hs c
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C02686
is: CHEBI:12947
type: Species
boundary condition: false
initial amount: NaN
name: D-galactosyl-N-acylsphingosine

http://identifiers.org/biomodels.db/MODEL1310110004#_a48d4b3d_2f7e_465c_bb08_6dc6b47bcc65
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: B2RDZ2
initial concentration: NaN
name: RFK
is encoded by: hsa:55312

http://identifiers.org/biomodels.db/MODEL1310110004#_60e828f8_142c_4512_8d84_d166061da6db
has only substance units: false
name: PDE8B
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8622
constant: false
is: SBO:0000252
type: Species
is: O95263

metaM man g
type: Species
is: SBO:0000247
is: CHEBI:16024
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00169
initial amount: NaN
boundary condition: false
name: D-mannose
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159

http://identifiers.org/biomodels.db/MODEL1310110004#_28ad5f85_be6b_4566_862a_dd34433ad0d4
name: HEXA
is: P06865
type: Species
constant: false
is encoded by: hsa:3073
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_a6e27c83_8a18_48ae_ab5d_95017a197881
is encoded by: hsa:84693
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: Q96PE7
type: Species
initial amount: NaN
is: SBO:0000252
name: MCEE

metaM cs c deg2 l
constant: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00127
is: CHEBI:15748
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 2
type: Species
is: SBO:0000247

metaM leuktrA4 e
is: SBO:0000247
is: CHEBI:57463
initial amount: NaN
initial concentration: 1.0
is: HMDB01337
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
type: Species
boundary condition: false
name: leukotriene A4(1-)
has only substance units: false

metaM dd3coa x
constant: false
name: 3-dodecenoylcoa
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
type: Species
boundary condition: false
is: HMDB04257
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_0cd2c651_8bed_4c01_afb9_77149056ac64
initial amount: NaN
type: Species
is: Q7Z7M8
is encoded by: hsa:374907
boundary condition: true
has only substance units: false
is: SBO:0000252
name: B3GNT8
initial concentration: NaN
constant: false

metaR r1580
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110004#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_629b33dc_572f_451b_8d7b_ffc8ac52fd30
is: C9JZ62
constant: false
name: TMEM91
has only substance units: false
is: SBO:0000252
is encoded by: hsa:641649
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_75297488_1ca5_4754_b76c_594d32d2e0d8
is: SBO:0000252
is encoded by: hsa:5805
type: Species
has only substance units: false
constant: false
name: PTS
initial amount: NaN
boundary condition: true
is: Q03393
initial concentration: NaN

metaM h g
initial amount: NaN
is: SBO:0000247
is: CHEBI:24636
has only substance units: false
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
type: Species
constant: false
name: proton

metaR SERHL
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:2674117 NOTES:MM
is described by: ECO:0000269
kinetic law: MODEL1310110004#
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110004#
name: L-Serine hydro-lyase
modifier: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/4.3.1.17

http://identifiers.org/biomodels.db/MODEL1310110004#_7bd7833d_2361_441e_a4da_c37f4fa34e1e
is: SBO:0000252
is encoded by: hsa:AV717590
initial concentration: NaN
name: _AV717590_1_m
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_e0777822_a712_4477_b176_34d54d4f5b86
name: ACOT4
is encoded by: hsa:122970
constant: false
boundary condition: true
type: Species
is: Q8N9L9
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaR HPYRDC
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.1.40 Confidence Level: 2 AUTHORS: PMID:3778681 NOTES:NCD
kinetic law: MODEL1310110004#
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110004#
name: hydroxypyruvate decarboxylase
product: MODEL1310110004#

metaR DURIPP
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
is: SBO:0000176
reversible: true
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.2.3
name: deoxyuridine phosphorylase
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110004#_832ab84f_44fc_4b1d_bbbd_b107b3ac55cf
is encoded by: hsa:6476
boundary condition: true
has only substance units: false
constant: false
is: P14410
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: SI

metaM man1p c
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06330
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
type: Species
is: CHEBI:35374
constant: false
name: D-Mannose 1-phosphate

http://identifiers.org/biomodels.db/MODEL1310110004#_9259f031_f899_4c99_beb6_b51d07ecafe8
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaM ppa e
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
has only substance units: false
type: Species
is: CHEBI:17272
constant: false
boundary condition: false
is: HMDB00237
initial amount: NaN
name: propionate

http://identifiers.org/biomodels.db/MODEL1310110004#_1f2d138e_042b_4b6e_ae4f_bab0b4205cf8
type: Species
boundary condition: true
is encoded by: hsa:10423
constant: false
name: CDIPT
has only substance units: false
initial concentration: NaN
is: O14735
is: SBO:0000252
initial amount: NaN

metaR MI145PP
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.86
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.3.36
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.56
is: SBO:0000176
name: inositol-1,4,5-trisphosphate 5-phosphatase
is described by: ECO:0000269
type: Reaction
fast: false
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_95d8a67b_e9dc_420e_b5d6_b93daf11e4cc
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:3420
boundary condition: true
name: IDH3B
type: Species

metaR r1583
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110004#

metaM h c
is: http://identifiers.org/pubchem.compound/3380
type: Species
name: proton
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
has only substance units: false
is: C00080
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:24636
boundary condition: false

metaR NADPtxu
reactant: MODEL1310110004#
fast: false
reversible: false
type: Reaction
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ potential for free H NJ
is described by: ECO:0000000
is: SBO:0000185
name: NADP transporter, peroxisome

http://identifiers.org/biomodels.db/MODEL1310110004#_0c5446ee_d92e_4dd3_8d14_ad9339cb3c98
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:10873
is: SBO:0000252
boundary condition: true
is: Q6TCH8
name: ME3

metaM m6mpdol U r
notes: FORMULA: C1605H2640N20O520P20 CHARGE: -20
is: CHEBI:37635
has only substance units: false
initial amount: NaN
constant: false
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_ad26b0d7_a469_4395_922d_1535433ad6dd
is: A0PJK1
name: SLC5A10
is encoded by: hsa:125206
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR EX sarcs LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sarcosine exchange
type: Reaction

metaM ocdcea e
notes: FORMULA: C18H33O2 CHARGE: -1
is: HMDB00207
has only substance units: false
is: CHEBI:0
initial concentration: 1.0
constant: false
is: C00712
is: SBO:0000247
boundary condition: false
type: Species
name: octadecenoate (n-C18:1)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_f1adc193_0787_41db_8e4e_fc7ff93b99a5
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SLC4A3
constant: false
is encoded by: hsa:6508
has only substance units: false

metaM CE0693 m
is: CHEBI:28387
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
initial amount: NaN
is: HMDB11123
name: 3-oxolaur-6-cis-enoyl-CoA
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
constant: false

metaM dcsptn1crn m
is: SBO:0000247
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial amount: NaN
constant: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
is: HMDB06321
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species

metaM h e
notes: FORMULA: H CHARGE: 1 INCHI: "
is: C00080
constant: false
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false
is: CHEBI:24636
is: SBO:0000247
initial concentration: 1.0
name: proton
type: Species

metaM gullac c
is: CHEBI:17587
type: Species
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB03466
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
name: L-gulono-1,4-lactone
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaM tetpent6 c
boundary condition: false
is: HMDB06322
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: tetracosapentaenoic acid, n-6
has only substance units: false
is: SBO:0000247

metaM Lcystin e
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB00192
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
initial amount: NaN
is: CHEBI:16283
has only substance units: false
name: L-cystine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_f502b778_b638_424f_8367_83b57eae0321
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: COX2
is: Q7GXZ8
is encoded by: hsa:4513
constant: false

metaM xmp c
has only substance units: false
boundary condition: false
is: C00655
is: SBO:0000247
name: Xanthosine 5'-phosphate
initial concentration: 1.0
notes: FORMULA: C10H11N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00478 EHMN_ABBREVIATION: C00655
type: Species
constant: false
is: HMDB01554
initial amount: NaN
is: CHEBI:57464

metaM ksii core4 pre10 g
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 10
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_46e7efe5_85ee_4eb9_bf67_2e67797147f3
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: GGT1
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:2678
is: P19440

metaR r1585
is described by: ECO:0000000
reversible: true
product: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110004#_b945d288_fb25_4aa1_80d1_c736da04a95d
boundary condition: true
is encoded by: hsa:5152
constant: false
type: Species
name: PDE9A
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM dha e
constant: false
is: HMDB01882
is: CHEBI:16016
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
is: SBO:0000247
name: glycerone
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0

metaR S6T12g
modifier: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110004#
is described by: ECO:0000000
product: MODEL1310110004#
type: Reaction
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110004#

metaR GACPAILter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
fast: false
product: MODEL1310110004#
reactant: MODEL1310110004#
reversible: false
kinetic law: MODEL1310110004#
is described by: ECO:0000000
name: glucosaminyl-acylphosphatidylinositol ER flippase
type: Reaction
is: SBO:0000185

metaM tymsf c
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
name: Tyramine O-sulfate
is: HMDB06409
constant: false
initial concentration: 1.0

metaM ocdcea c
has only substance units: false
type: Species
is: C00712
boundary condition: false
name: octadecenoate (n-C18:1)
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1
is: HMDB00207
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110004#_d67ec60e_9226_4378_8f7d_01ece22b05fe
initial concentration: NaN
name: NT5C1B
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:93034
is: Q96P26

metaM gacpail hs c
is: CHEBI:61548
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB01401
constant: false
is: C00092
type: Species
name: glucosaminyl-acylphosphatidylinositol
initial concentration: 1.0
is: SBO:0000247

metaM grdp x
constant: false
name: geranyl diphosphate(3-)
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:58057
initial amount: NaN
is: HMDB01285

metaR HCO3 CLt
reversible: true
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
is: SBO:0000185
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
is described by: ECO:0000269
fast: false
name: bicarbonate transport (Cl-/HCO3- exchange)
reactant: MODEL1310110004#

metaM tetpent6 e
is: SBO:0000247
is: HMDB06322
type: Species
initial amount: NaN
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-23H2,1H3,(H,25,26)/b7-6-,10-9-,13-12-,16-15-,19-18-
constant: false
boundary condition: false
name: tetracosapentaenoic acid, n-6
initial concentration: 1.0
has only substance units: false

metaR r1584
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_df1a40fc_4982_4dbe_9a2c_964dbe49d1f1
type: Species
is encoded by: hsa:8310
is: O15254
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
name: ACOX3

metaR MI145PK
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.127
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
kinetic law: MODEL1310110004#
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110004#
product: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000176
name: inositol-1,4,5-trisphosphate 3-kinase

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaR r0911
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
product: MODEL1310110004#
is described by: ECO:0000000
name: Facilitated diffusion
kinetic law: MODEL1310110004#
is: SBO:0000185
reactant: MODEL1310110004#
fast: false
type: Reaction
reversible: true

metaR EX imp LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_ef19387d_6642_4aee_be65_3cbb2f472bad
name: BCAT2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:587
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: O15382
is: SBO:0000252

metaM man l
is: SBO:0000247
constant: false
is: HMDB00169
initial concentration: 1.0
is: CHEBI:16024
boundary condition: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
has only substance units: false
initial amount: NaN
name: D-mannose

metaR r1587
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
reactant: MODEL1310110004#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110004#

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_5d60637a_ffe7_4fea_94f0_edb83c1f2dfe
name: _M68895_1_c
constant: false
is encoded by: hsa:M68895
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM occoa c
is: CHEBI:57386
constant: false
is: SBO:0000247
is: C01944
type: Species
is: HMDB01070
name: Octanoyl-CoA (n-C8:0CoA)
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944

http://identifiers.org/biomodels.db/MODEL1310110004#_3c15dbf3_c3d3_498c_8208_66b23c08280d
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:5151
initial concentration: NaN
is: H0YMZ7
boundary condition: true
name: PDE8A
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_82da9341_c185_4d3f_b92f_13ec7c836067
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:1836
initial concentration: NaN
initial amount: NaN
is: P50443
name: SLC26A2
constant: false

metaM tymsf e
is: SBO:0000247
has only substance units: false
is: HMDB06409
boundary condition: false
notes: FORMULA: C8H11NO4S CHARGE: 0 INCHI: InChI=1/C8H11NO4S/c9-6-5-7-1-3-8(4-2-7)13-14(10,11)12/h1-4H,5-6,9H2,(H,10,11,12)
constant: false
name: Tyramine O-sulfate
initial amount: NaN
type: Species
initial concentration: 1.0

metaM nadh x
is: CHEBI:57945
is: http://identifiers.org/pubchem.compound/3306
type: Species
is: HMDB01487
name: Nicotinamide adenine dinucleotide - reduced
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: C00004
initial amount: NaN

metaR ASPPROASCT1
reversible: false
is described by: ECO:0000134
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
fast: false
type: Reaction
name: aspartate intake by system ASCT-1 transporter
modifier: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_0773a07b_9f1a_48fe_8e98_9c8a89a561eb
is encoded by: hsa:6319
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is: O00767
name: SCD
has only substance units: false

metaR RE1532M
name: RE1532
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
product: MODEL1310110004#
fast: false
is: SBO:0000176
modifier: MODEL1310110004#

metaR PIt8
is described by: ECO:0000006
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
name: phosphate transport in/out via Na+ symporter
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
reactant: MODEL1310110004#
is: SBO:0000185
reversible: true
fast: false
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_cd47ff84_cb81_407d_b5fb_f3f728233405
name: AMY2A
constant: false
is encoded by: hsa:279
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P04746
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_de7ed1fc_9193_4def_9cbe_624c0a6f8de8
has only substance units: false
name: TYMS
is: P04818
is encoded by: hsa:7298
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN

metaR CITt4 4
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
is described by: ECO:0000006
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
product: MODEL1310110004#
name: citrate transport via sodium symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_f368cb5e_e19f_417c_bb2a_1d2482a12b33
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
name: CA5B
is: SBO:0000252
is encoded by: hsa:11238
is: Q9Y2D0

metaR NDPK2
is: SBO:0000176
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
name: nucleoside-diphosphate kinase (ATP:UDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
modifier: MODEL1310110004#
fast: false
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000269

metaR PEPCKm
is version of: http://identifiers.org/ec-code/4.1.1.32
reactant: MODEL1310110004#
product: MODEL1310110004#
reversible: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
is: SBO:0000176
type: Reaction
modifier: MODEL1310110004#
name: Phosphoenolpyruvate carboxykinase (GTP)
is described by: ECO:0000000
fast: false

metaM pro L m
constant: false
name: L-proline
initial amount: NaN
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
type: Species
is: CHEBI:17203
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00162
boundary condition: false

metaM pyr c
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1
is: CHEBI:15361
is: http://identifiers.org/pubchem.compound/3324
is: C00022
initial amount: NaN
is: HMDB00243
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
constant: false
name: pyruvate

metaM pyr e
boundary condition: false
is: CHEBI:15361
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: HMDB00243
name: pyruvate
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_bec9c409_66e2_4527_9436_7e21ae97e439
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:250
is: P05187
boundary condition: true
is: SBO:0000252
name: ALPP

metaR GLCNACT U
reactant: MODEL1310110004#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
fast: false
reversible: false

metaM 3hmp m
has only substance units: false
is: CHEBI:11805
is: HMDB00023
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
name: 3-hydroxy-2-methylpropanoate
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_808308b8_222a_4708_b38c_e73564b061b3
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10999
name: SLC27A4
constant: false
boundary condition: true
type: Species
is: Q6P1M0

metaM ps hs e
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
name: phosphatidylserine
is: CHEBI:18303
type: Species
initial amount: NaN

metaR r1586
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR DRPA
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
reversible: false
kinetic law: MODEL1310110004#
product: MODEL1310110004#
name: deoxyribose-phosphate aldolase
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_9b51befc_8ff8_49e5_8f40_3adc7c4c8984
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4830
is: SBO:0000252
name: NME1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_200248d9_40fe_4218_863c_ad3418d9b850
initial concentration: NaN
is: SBO:0000252
name: NDUFA5
has only substance units: false
boundary condition: true
is encoded by: hsa:4698
initial amount: NaN
is: Q16718
constant: false
type: Species

metaM arachdcoa x
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
is: HMDB06523
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57368
type: Species
has only substance units: false
initial amount: NaN
name: arachidonoyl-CoA(4-)
initial concentration: 1.0

metaR ADSK
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.25
modifier: MODEL1310110004#
name: adenylyl-sulfate kinase
reversible: false
fast: false
kinetic law: MODEL1310110004#
is: SBO:0000176

metaR NAGA2ly
type: Reaction
fast: false
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.49
name: N-acetylgalactosaminidase, alpha-
is described by: ECO:0000000
reactant: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
modifier: MODEL1310110004#
reversible: false

metaR PIt7
type: Reaction
name: phosphate transport in/out via three Na+ symporter
product: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
reactant: MODEL1310110004#
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
reversible: true
is: SBO:0000185

metaM dgsn c
name: Deoxyguanosine
boundary condition: false
type: Species
is: HMDB00085
is: CHEBI:17172
constant: false
initial concentration: 1.0
is: SBO:0000247
is: C00330
initial amount: NaN
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
has only substance units: false

metaR NDPK1
type: Reaction
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110004#
name: nucleoside-diphosphate kinase (ATP:GDP)
is described by: ECO:0000134
reactant: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#

metaM fuc1p L c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
is: CHEBI:28319
constant: false
has only substance units: false
name: L-Fucose 1-phosphate
is: HMDB01265
is: SBO:0000247
type: Species

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaR DGK1
reactant: MODEL1310110004#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.4.8
reversible: true
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110004#
product: MODEL1310110004#
name: deoxyguanylate kinase (dGMP:ATP)
fast: false

metaR AKGMALtm
kinetic law: MODEL1310110004#
fast: false
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110004#
name: alpha-ketoglutarate/malate transporter
is: SBO:0000185
modifier: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV

metaR 4HOXPACDOX NADP
fast: false
product: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000304
type: Reaction
modifier: MODEL1310110004#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
kinetic law: MODEL1310110004#

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR RE1836X
product: MODEL1310110004#
fast: false
modifier: MODEL1310110004#
name: RE1836
is: SBO:0000176
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_30cf2a23_def0_46fc_8d4f_15bbac3e3137
boundary condition: true
has part: B7Z2T0
initial amount: NaN
is encoded by: hsa:478
is: SBO:0000297
type: Species
is encoded by: hsa:481
has only substance units: false
has part: A3KLL5
constant: false
name: ATP1A3:ATP1B1
initial concentration: NaN

metaR G14Tg
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
reversible: false
product: MODEL1310110004#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
type: Reaction
modifier: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000269

metaR VALTAm
reversible: true
modifier: MODEL1310110004#
fast: false
name: valine transaminase, mitochondiral
reactant: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
type: Reaction

metaM doco13ac e
is: SBO:0000247
is: HMDB02068
has only substance units: false
type: Species
name: docosenoic acid (C22:1)
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C22H41O2 CHARGE: -1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_3d67d8b4_b678_4dae_b397_025e7e62dd34
initial amount: NaN
is encoded by: hsa:22305
has only substance units: false
boundary condition: true
type: Species
constant: false
name: _22305_2_c
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_ee51fe6d_e3b2_4d6f_9f25_e390989f6064
is: A6NN98
type: Species
is encoded by: hsa:8898
name: MTMR2
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM hs deg6 l
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB01352
name: heparan sulfate, degradation product 6
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
boundary condition: false
initial amount: NaN
is: CHEBI:17180

http://identifiers.org/biomodels.db/MODEL1310110004#_6f8f4415_7b6a_478c_9b8b_9f1812f22c50
constant: false
is: O75251
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:374291
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
name: NDUFS7

metaR ADSS
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.3.4.4
type: Reaction
modifier: MODEL1310110004#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
is described by: ECO:0000134
reactant: MODEL1310110004#
fast: false
name: adenylosuccinate synthase

http://identifiers.org/biomodels.db/MODEL1310110004#_da8218ce_0783_47f3_aa05_4991dd9d9584
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:2629
boundary condition: true
name: GBA
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR P4508B11r
fast: false
reactant: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
type: Reaction
is described by: ECO:0000269
reversible: false
name: sterol 12-alpha-hydroxylase
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.14.13.95
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_8c68b6fa_242b_4fff_95b6_9b2b8096ec6e
is encoded by: hsa:8527
name: DGKD
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false

metaM HC02216 c
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta
boundary condition: false
constant: false
is: CHEBI:28922
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_4e0a5d3f_cc92_4e85_a51a_a9399e432af2
name: PLCD4
is: SBO:0000252
is: Q9BRC7
type: Species
initial concentration: NaN
is encoded by: hsa:84812
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

metaR r0726
fast: false
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.1.33
reactant: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#
type: Reaction
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211

metaR r0839
modifier: MODEL1310110004#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.1.70
is: SBO:0000185
name: Postulated transport reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_a16763f4_9f50_4036_9e11_429158cbbe50
initial amount: NaN
is encoded by: hsa:8395
is: O14986
name: PIP5K1B
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaR EX 3ivcrn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaR SEBACACT
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of sebacic acidd
type: Reaction

metaM ksi pre34 g
has only substance units: false
is: C00130
is: HMDB00175
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 34
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_53c3a4f9_0aa6_4eb2_9130_a0398374165e
constant: false
is encoded by: hsa:3420
name: IDH3B
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: O43837
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_b547f1c8_b94e_4f82_8057_15ae62790849
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: QPRT
is: Q15274
constant: false
is encoded by: hsa:23475

http://identifiers.org/biomodels.db/MODEL1310110004#_604897f6_c0df_4507_a167_9c159fb85ebc
constant: false
boundary condition: true
is encoded by: hsa:4668
is: P17050
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: NAGA

http://identifiers.org/biomodels.db/MODEL1310110004#_e204ba43_017a_4de4_86d8_d9023d5acb25
is encoded by: hsa:AU149534
constant: false
initial concentration: NaN
type: Species
has only substance units: false
name: _AU149534_1_m
is: SBO:0000252
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_cd9a1c02_5083_4438_b299_ae111c906ec7
constant: false
name: PDE10A
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q9Y233
type: Species
initial amount: NaN
is encoded by: hsa:10846
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_cc4facc6_0db4_416a_a0cf_4f28aad71e60
is encoded by: hsa:2530
is: B4DFS7
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: FUT8
constant: false
type: Species
initial concentration: NaN

metaR OCD11CRNCPT2
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaR FAOXC163x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_fucgalacgalfuc12gal14acglcgalgluside_hs_g
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:57847
is: HMDB00304
type: Species
notes: FORMULA: C70H122N3O40FULLRCO CHARGE: 0
constant: false
is: SBO:0000247
name: Type IIIH glycolipid
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_7ec97e28_4832_4ca1_b391_cf76923d2917
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:8564
constant: false
is: O15229
boundary condition: true
name: KMO
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_d105c53f_e65c_47b6_97ab_1ce542b2a73e
name: SLC6A2
is: Q96KH8
is encoded by: hsa:6530
type: Species
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR ACOAO7p
fast: false
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
product: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000176
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
reversible: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.3.6

http://identifiers.org/biomodels.db/MODEL1310110004#_ecb55279_5f1f_4ce3_ac7e_917f56a0d471
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
name: CYP8B1
initial concentration: NaN
is encoded by: hsa:1582
is: Q9UNU6

metaM mi3p D c
initial amount: NaN
type: Species
boundary condition: false
constant: false
name: 1D-myo-inositol 3-phosphate(2-)
is: CHEBI:58401
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB06814
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110004#_df9c9c4d_6d99_43e0_8c24_26a71516f50e
type: Species
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:7372
initial amount: NaN
name: UMPS
is: A8K5J1

metaR r0728
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000176
type: Reaction
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110004#
fast: false

metaM ksi pre26 g
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:28067
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
constant: false
name: keratan sulfate I biosynthesis, precursor 26
boundary condition: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_202cb576_3bf9_4661_b95f_509b20e39152
boundary condition: true
type: Species
is encoded by: hsa:4842
initial concentration: NaN
initial amount: NaN
is: B4DG68
constant: false
has only substance units: false
name: NOS1
is: SBO:0000252

metaM man6p c
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: D-Mannose 6-phosphate
is: HMDB01078
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
constant: false
boundary condition: false
type: Species
is: CHEBI:17369
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_3efb2adb_88fb_4018_ab51_e887dec34e61
is encoded by: hsa:9514
constant: false
initial concentration: NaN
initial amount: NaN
is: Q99999
type: Species
boundary condition: true
is: SBO:0000252
name: GAL3ST1
has only substance units: false

metaM leuktrA4 r
initial concentration: 1.0
name: leukotriene A4(1-)
has only substance units: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: HMDB01337
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57463
boundary condition: false
constant: false

metaR NACHEX21ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
kinetic law: MODEL1310110004#
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110004#
reversible: false
modifier: MODEL1310110004#
product: MODEL1310110004#

metaM glyc m
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
has only substance units: false
name: Glycerol
initial concentration: 1.0
is: CHEBI:17754
is: SBO:0000247
is: C00116
type: Species
boundary condition: false
is: HMDB00131
constant: false
initial amount: NaN

metaR HXPRT
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reversible: false
product: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.8

http://identifiers.org/biomodels.db/MODEL1310110004#_2453c301_cc2c_4642_8caf_d3a8cf5915d7
boundary condition: true
type: Species
is: Q9HAS3
is encoded by: hsa:64078
initial concentration: NaN
name: SLC28A3
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_269f14d5_569b_4019_bac6_d6fc83f14a53
is encoded by: hsa:8560
boundary condition: true
initial amount: NaN
name: DEGS1
constant: false
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR r0629
modifier: MODEL1310110004#
reversible: true
is version of: http://identifiers.org/ec-code/3.6.1.22
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000000
type: Reaction
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is: SBO:0000176
product: MODEL1310110004#
fast: false

metaR r0403
is described by: ECO:0000000
fast: false
product: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.4 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.2.4.4
type: Reaction
reversible: true
is: SBO:0000176
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) Tryptophan metabolism EC:1.14.16.4
kinetic law: MODEL1310110004#

metaM 3mop m
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00491
initial concentration: 1.0
is: CHEBI:28654
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
boundary condition: false
name: 3-methyl-2-oxopentanoate
constant: false

metaM 3hddcoa m
has only substance units: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
is: HMDB11123
boundary condition: false
is: SBO:0000247
name: (S)-3-Hydroxydodecanoyl-CoA
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
is: C05279

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR HISSNAT5tc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_972c0cd2_8e56_4e1f_a2c6_e8f353ac00b3
initial concentration: NaN
boundary condition: true
is: E7EQF2
is: SBO:0000252
is encoded by: hsa:54677
name: CROT
initial amount: NaN
constant: false
type: Species
has only substance units: false

metaM octdececoa c
initial amount: NaN
name: octadecenoylcoa
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
constant: false
is: HMDB06351
is: SBO:0000247

metaR r0082
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.6.1.2
reversible: true
is: SBO:0000176
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42

metaR 34DHXMANDACOX
reversible: false
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
modifier: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000269
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#

metaR r0723
kinetic law: MODEL1310110004#
is described by: ECO:0000000
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110004#
product: MODEL1310110004#
reversible: false
fast: false

metaM h2o2 e
constant: false
type: Species
boundary condition: false
is: CHEBI:16240
is: SBO:0000247
name: hydrogen peroxide
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027

metaR RE2999M
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
modifier: MODEL1310110004#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/5.3.3.8
name: RE2999
reversible: true

metaM dcholcoa c
initial concentration: 1.0
is: HMDB06292
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial amount: NaN
has only substance units: false
name: chenodeoxycholoyl coenzyme a
type: Species
is: SBO:0000247
is: CHEBI:28701
boundary condition: false
constant: false

metaM ksi pre1 g
notes: FORMULA: C79H129N5O57X CHARGE: -1
boundary condition: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 1
initial concentration: 1.0
is: SBO:0000247
is: HMDB00175
type: Species
is: CHEBI:58053
is: C00130
has only substance units: false
constant: false

metaM dodecanac c
is: HMDB00623
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C12H20O4 CHARGE: -2
name: Dodecanedioic acid
boundary condition: false
constant: false
initial amount: NaN
type: Species

metaR RE3006M
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/4.2.1.17
name: RE3006
reversible: true
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false

metaM 5thf m
is: SBO:0000247
is: C00440
constant: false
is: CHEBI:3729
is: HMDB01396
initial amount: NaN
boundary condition: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
has only substance units: false
initial concentration: 1.0
type: Species
name: pentaglutamyl folate (THF)

metaR PSYGCHe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of psyllium with glycocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR C81CRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

metaM mev R x
is: HMDB00227
boundary condition: false
initial amount: NaN
is: CHEBI:36464
initial concentration: 1.0
constant: false
name: (R)-mevalonate
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
type: Species

metaR TDCRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

metaM taur e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00251
is: C00245
is: CHEBI:3544
notes: FORMULA: C2H7NO3S CHARGE: 0
name: Taurine
initial amount: NaN
constant: false
boundary condition: false
type: Species

metaR r0081
product: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110004#
name: L-Alanine:2-oxoglutarate aminotransferase Glutamate metabolism / Alanine and aspartate metabolism EC:2.6.1.2
is version of: http://identifiers.org/ec-code/1.5.1.12
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Citric acid cycle EC Number: 2.6.1.2 Confidence Level: 0 AUTHORS: PMID:15663181,PMID:2088925,PMID:454616 NOTES:
modifier: MODEL1310110004#

metaR RE0915E
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17
kinetic law: MODEL1310110004#
name: RE0915
product: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
fast: false
modifier: MODEL1310110004#
type: Reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

metaR r0722
type: Reaction
modifier: MODEL1310110004#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/4.2.3.12
reactant: MODEL1310110004#
is described by: ECO:0000000
product: MODEL1310110004#
reversible: true
fast: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is: SBO:0000176

metaR SUBERCROT
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

metaM 5thf l
has only substance units: false
type: Species
name: pentaglutamyl folate (THF)
is: CHEBI:3729
is: HMDB01396
boundary condition: false
notes: FORMULA: C39H45N11O18 CHARGE: -6
initial concentration: 1.0
is: SBO:0000247
is: C00440
constant: false
initial amount: NaN

metaM pre prot r
has only substance units: false
constant: false
type: Species
is: CHEBI:16240
is: SBO:0000247
is: HMDB03125
notes: FORMULA: XY CHARGE: 0
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: glycophosphatidylinositol (GPI)-anchored protein precursor

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR r0627
fast: false
reversible: true
reactant: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110004#
kinetic law: MODEL1310110004#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:

metaR FAOXC184m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization of (C18:4)m
type: Reaction

metaR C16OHc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecanoylcarnitinec
type: Reaction

metaR APOCF
product: MODEL1310110004#
reactant: MODEL1310110004#
name: Apocarboxylase formation
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
kinetic law: MODEL1310110004#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110004#_639fd47c_f605_42f2_aea2_1d5bb35552d8
type: Species
boundary condition: true
is: SBO:0000297
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN
has only substance units: false
has part: P48201
is encoded by: hsa:518
constant: false

metaR r0400
is version of: http://identifiers.org/ec-code/1.2.4.4
reactant: MODEL1310110004#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110004#
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_dfa9a30e_9f5d_4051_a872_2bc851c999a3
is: B3KRT1
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:51477
name: ISYNA1

metaR RE0830N
type: Reaction
fast: false
reactant: MODEL1310110004#
reversible: true
product: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
kinetic law: MODEL1310110004#
name: RE0830
is described by: ECO:0000000

metaM h2o2 c
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
name: Hydrogen peroxide
boundary condition: false
type: Species
constant: false
is: CHEBI:16240
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C00027

metaM 3hdcoa c
has only substance units: false
type: Species
constant: false
name: (S)-3-Hydroxydecanoyl-CoA
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
is: HMDB00651
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_deebe6dd_c846_4796_9f1d_b652a268b870
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: P55084
is encoded by: hsa:3032
has only substance units: false
is: SBO:0000252
name: HADHB

metaM pydxn c
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
name: Pyridoxine
type: Species
is: HMDB00239
is: C00314
is: CHEBI:16709
initial concentration: 1.0
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_caf46400_6a65_40de_a0dc_deffdc43e74c
boundary condition: true
name: FLAD1
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:80308
is: Q8NFF5
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_2ac2f674_319e_4d5a_9c9d_eb1f1e1d1b10
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: SULT1A1
is encoded by: hsa:6817
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_aa95a8d0_2790_4c9a_b2a1_f202bdf07e97
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
name: AICDA
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:57379
is: Q546Y9

metaM taur c
name: Taurine
initial concentration: 1.0
boundary condition: false
is: HMDB00251
is: CHEBI:3544
has only substance units: false
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0
is: SBO:0000247
is: C00245

http://identifiers.org/biomodels.db/MODEL1310110004#_b7f40c91_35df_4cc0_8a0f_211fae0c4d34
boundary condition: true
name: CA2
is: P00918
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:760
type: Species
has only substance units: false

metaR r0724
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000000
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110004#
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_35d79d82_1d81_413a_a29f_1f77cf1686ca
is: SBO:0000297
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
type: Species
initial amount: NaN
has only substance units: false
has part: P56134
constant: false
initial concentration: NaN
is encoded by: hsa:9551
boundary condition: true
is encoded by: hsa:522

metaM 2hexdtricoa x
boundary condition: false
constant: false
is: HMDB02288
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
name: 2,7,10-hexadecatrienoylcoa
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_7583960a_7c59_4c64_bf5e_cc6ce254709a
boundary condition: true
is: SBO:0000252
name: PKLR
has only substance units: false
is encoded by: hsa:5313
initial amount: NaN
constant: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_90d66d52_7a59_4513_8776_86e9859b467d
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: O95139
is: SBO:0000252
name: NDUFB6
type: Species
is encoded by: hsa:4712
initial concentration: NaN

metaR FAOXC184x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C18:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_4063a0c8_8209_466c_b13e_cde7db108770
initial amount: NaN
is encoded by: hsa:4191
has only substance units: false
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: P40926
is: SBO:0000252
name: MDH2

http://identifiers.org/biomodels.db/MODEL1310110004#_cca164c2_1169_4bc2_b662_df4f019687af
is: B3KXY9
constant: false
boundary condition: true
has only substance units: false
name: HK1
is encoded by: hsa:3098
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

metaM sql r
is: HMDB00256
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:15440
name: squalene
initial concentration: 1.0
constant: false
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751

metaM CE4794 m
type: Species
is: CHEBI:57923
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: cis-6-dodecenoyl-CoA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_1bd1f3b3_12d0_443e_a056_c7f5827593f2
name: IDUA
initial concentration: NaN
is: SBO:0000252
is: P35475
has only substance units: false
type: Species
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:3425

metaM glyc c
is: C00116
name: Glycerol
boundary condition: false
type: Species
is: HMDB00131
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_8e31f9e1_0e1d_433a_bc5f_247d592d4b41
is encoded by: hsa:5092
type: Species
is: P61457
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
name: PCBD1
initial concentration: NaN
has only substance units: false

metaR C3STKR2r
reactant: MODEL1310110004#
is: SBO:0000176
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: false
name: C-3 sterol keto reductase (zymosterol)
type: Reaction
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000134
fast: false
product: MODEL1310110004#

metaR MEOHt2
fast: false
name: Methanol diffusion
reversible: true
reactant: MODEL1310110004#
is: SBO:0000185
product: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_bf43eb8c_cff4_43d4_b0ed_0472104f4203
has only substance units: false
is encoded by: hsa:HG2846-HT2983
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
name: _HG2846_HT2983_1_c
type: Species
is: SBO:0000252

metaR GTHP
is version of: http://identifiers.org/ec-code/1.11.1.9
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.11.1.12
is version of: http://identifiers.org/ec-code/1.11.1.15
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
modifier: MODEL1310110004#
name: glutathione peroxidase
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
kinetic law: MODEL1310110004#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_eeb04f75_c421_456f_85dd_c33cae15bc90
initial concentration: NaN
name: PDE5A
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8654
constant: false

metaM ala L c
is: HMDB00161
is: CHEBI:16977
has only substance units: false
boundary condition: false
constant: false
name: L-alanine
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_3710d624_855b_4c68_8627_e61208a47009
boundary condition: true
is: A0PJJ9
is: SBO:0000252
name: GGT7
is encoded by: hsa:2686
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM ksi pre20 g
is: SBO:0000247
initial amount: NaN
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 20
type: Species
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0

metaR RE0958E
fast: false
is: SBO:0000176
reactant: MODEL1310110004#
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110004#
product: MODEL1310110004#
name: RE0958
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110004#

metaR CYTK4n
name: cytidylate kinase (dCMP,GTP),nuclear
modifier: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110004#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_86d4d49d_035d_48e0_a840_068a1a3b00db
is: P57054
boundary condition: true
constant: false
name: PIGP
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:51227
has only substance units: false
is: SBO:0000252

metaR KSII CORE4t
kinetic law: MODEL1310110004#
name: keratan sulfate II (core4) transport, golgi to extracellular
is: SBO:0000185
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is described by: ECO:0000000
fast: false
type: Reaction

metaR CRVNCtr
fast: false
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reversible: true
name: fatty acid transport via diffusion
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_c012a9b0_d5f8_401e_a81f_aaf55a8cfada
is: E9PH29
is encoded by: hsa:10935
initial concentration: NaN
name: PRDX3
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

metaR S6TASE22ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
reversible: true
name: galactose-6-sulfate sulfatase, lysosomal
is: SBO:0000176
type: Reaction
modifier: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.4.16.5

http://identifiers.org/biomodels.db/MODEL1310110004#_db52eab2_2db1_4ec6_bf25_8171049cb755
is: Q96AT9
name: RPE
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:6120
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_1952fd04_fc95_4c24_b7fd_718ae4a4c50d
is: SBO:0000252
is: P00533
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
name: EGFR
is encoded by: hsa:1956
boundary condition: true

metaM r5p c
initial concentration: 1.0
initial amount: NaN
name: alpha-D-Ribose 5-phosphate
is: C00117
boundary condition: false
type: Species
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
constant: false
has only substance units: false
is: CHEBI:18189
is: SBO:0000247
is: HMDB00618

http://identifiers.org/biomodels.db/MODEL1310110004#_c8dce8b2_afb9_4254_9776_1db292fb6836
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:1103
constant: false
has only substance units: false
is: SBO:0000252
type: Species
name: CHAT
is: P28329

metaM 3hexdtricoa m
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB02288
name: 3,7,10-hexadecatrienoylcoa

http://identifiers.org/biomodels.db/MODEL1310110004#_d09479e8_f9cd_4c40_a5a1_c942c6b69f8a
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SLC14A1
is: G0W2N5
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:6563
boundary condition: true

metaR C4STMO1r
kinetic law: MODEL1310110004#
fast: false
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.14.13.72
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
modifier: MODEL1310110004#
is: SBO:0000176

metaM hs deg23 l
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
type: Species
is: HMDB02704
is: CHEBI:21338
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C31H49NO29S CHARGE: -2

metaR AICART
reversible: true
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
type: Reaction
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
is: SBO:0000176
fast: false
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.1.2.3
product: MODEL1310110004#

metaR r0834
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110004#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is version of: http://identifiers.org/ec-code/3.5.4.16
kinetic law: MODEL1310110004#
type: Reaction
fast: false
reactant: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#

metaR LPS3
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reversible: false
type: Reaction
modifier: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.1.23
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
name: lipase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_1bbf4717_5851_4f6c_b49e_45f5589918d3
has only substance units: false
boundary condition: true
is encoded by: hsa:5152
is: SBO:0000252
name: PDE9A
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

metaR DHCHOLESTANATEtm
kinetic law: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
name: lipid, flip-flop intracellular transport
is: SBO:0000185
reactant: MODEL1310110004#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110004#

metaM ala L e
constant: false
is: CHEBI:16977
boundary condition: false
has only substance units: false
name: L-alanine
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
type: Species
is: HMDB00161

http://identifiers.org/biomodels.db/MODEL1310110004#_8fc34cac_68fd_47e8_b02e_ee05cb0de6ef
boundary condition: true
is: P04075
name: ALDOA
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:226
has only substance units: false
initial amount: NaN

metaM mpdol U c
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:18396
is: SBO:0000247
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20

http://identifiers.org/biomodels.db/MODEL1310110004#_9a375534_b7d7_4d59_89f6_30e5d377a55f
type: Species
is: SBO:0000252
is encoded by: hsa:4718
name: NDUFC2
initial amount: NaN
has only substance units: false
is: Q549M5
boundary condition: true
initial concentration: NaN
constant: false

metaM glyc e
is: HMDB00131
constant: false
type: Species
is: CHEBI:17754
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial amount: NaN
is: SBO:0000247
is: C00116
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: Glycerol

http://identifiers.org/biomodels.db/MODEL1310110004#_73396803_74d1_4d06_bd81_a8400255f361
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:51179
name: HAO2
is: SBO:0000252
type: Species

metaM cbasp c
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
is: C00438
is: HMDB00828
is: CHEBI:32814
initial concentration: 1.0
constant: false
initial amount: NaN
name: N-Carbamoyl-L-aspartate

metaM dopa e
constant: false
is: CHEBI:59905
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
name: dopaminium(1+)
is: HMDB00073
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
is: SBO:0000247

metaR EX psylchol LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium-glycocholic acid complex
type: Reaction

metaR FACOAL244 1
type: Reaction
kinetic law: MODEL1310110004#
name: fatty-acid--CoA ligase
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110004#
reversible: true
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ

metaR S6TASE15ly
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
kinetic law: MODEL1310110004#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
type: Reaction
product: MODEL1310110004#

metaR LEUGLYHYc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
kinetic law: MODEL1310110004#
is: SBO:0000176
name: hydrolysis of leucylglycine
reversible: true
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
fast: false

metaR FAEL205
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
modifier: MODEL1310110004#
is described by: ECO:0000000
name: fatty-acyl-CoA elongation (n-C20:5CoA)
product: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000176
fast: false
reversible: false

metaM h2o2 n
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN
is: CHEBI:16240
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: HMDB03125
type: Species
name: hydrogen peroxide

metaM 5thf e
notes: FORMULA: C39H45N11O18 CHARGE: -6
name: pentaglutamyl folate (THF)
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB06487
initial amount: NaN
initial concentration: 1.0
constant: false

metaR DOPAtu
reversible: true
reactant: MODEL1310110004#
product: MODEL1310110004#
name: Dopamine uniport
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110004#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_43dc8cef_d468_4526_9452_029b6a6b820c
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: Q9NP59
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:30061
name: SLC40A1
boundary condition: true

metaR r2140
fast: false
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reversible: true
reactant: MODEL1310110004#
type: Reaction
product: MODEL1310110004#

metaR FAS80COA L
is: SBO:0000176
fast: false
product: MODEL1310110004#
type: Reaction
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000269
reactant: MODEL1310110004#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110004#_80db6fcc_495c_47a8_a439_e40270e1bbf6
initial concentration: NaN
type: Species
name: TAZ
initial amount: NaN
constant: false
has only substance units: false
is: Q16635
is encoded by: hsa:6901
is: SBO:0000252
boundary condition: true

metaR r0836
kinetic law: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/3.5.4.16
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
fast: false

metaM h2o2 m
name: Hydrogen peroxide
is: SBO:0000247
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: C00027
is: HMDB03125
has only substance units: false
is: CHEBI:16240

http://identifiers.org/biomodels.db/MODEL1310110004#_d5cb55ef_0ce3_4053_b40a_63c27a1c95ec
boundary condition: true
is encoded by: hsa:686
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: BTD
is: P43251
type: Species

metaM HC02214 e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
name: prostaglandin-f1alpha
has only substance units: false
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:28852

metaM dopa c
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
initial concentration: 1.0
is: CHEBI:59905
has only substance units: false
boundary condition: false
constant: false
name: dopaminium(1+)
initial amount: NaN
type: Species
is: HMDB00073
is: SBO:0000247

metaR RE0830C
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110004#
product: MODEL1310110004#
name: RE0830
reactant: MODEL1310110004#

metaM lac D e
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
name: (R)-lactate
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
is: CHEBI:16004
initial concentration: 1.0
is: HMDB01311
constant: false

metaR CHSTEROLt1
is described by: ECO:0000304
product: MODEL1310110004#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
modifier: MODEL1310110004#
reversible: true
name: cholesterol intracellular transport

metaR FAOXC225m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

metaR r2141
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110004#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
kinetic law: MODEL1310110004#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110004#

metaR TETDEC2CRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaR PAIL45P HStn
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_32c062a8_af44_493f_a22b_863a57b8029a
is: Q14376
initial amount: NaN
has only substance units: false
name: GALE
type: Species
initial concentration: NaN
is encoded by: hsa:2582
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_9a3745c3_e7e0_4509_b945_34ea842fbd08
constant: false
initial amount: NaN
is encoded by: hsa:80704
is: SBO:0000252
type: Species
is: Q9BZV2
name: SLC19A3
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaM peamn c
is: SBO:0000247
initial amount: NaN
is: CHEBI:225237
type: Species
is: HMDB12275
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: 2-phenylethanaminium
constant: false

metaR GMAND
modifier: MODEL1310110004#
is: SBO:0000176
name: GDP-D-mannose dehydratase
product: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.47
reversible: false
kinetic law: MODEL1310110004#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_a0a6c70a_c70a_4af8_b865_5b72e979bd38
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:57665
name: RDH14
boundary condition: true
is: Q9HBH5
constant: false

metaR CHSTEROLt2
name: cholesterol intracellular transport
product: MODEL1310110004#
is: SBO:0000185
reactant: MODEL1310110004#
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110004#
type: Reaction

metaR r2142
fast: false
product: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110004#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true

metaR ECOAH9m
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
type: Reaction
kinetic law: MODEL1310110004#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110004#
fast: false
is described by: ECO:0000304

metaR r0838
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
modifier: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.2.4
kinetic law: MODEL1310110004#
type: Reaction
reversible: true
product: MODEL1310110004#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Free diffusion

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

metaR HOMt4
fast: false
is: SBO:0000185
product: MODEL1310110004#
name: L-homoserine via sodium symport
reversible: false
notes: GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
is described by: ECO:0000269
modifier: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#

metaM 3hdcoa m
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
boundary condition: false
type: Species
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
name: (S)-3-Hydroxydecanoyl-CoA
initial amount: NaN

metaR ACACT1x
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
kinetic law: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
reactant: MODEL1310110004#
is described by: ECO:0000134
reversible: false
name: acetyl-CoA C-acetyltransferase, mitochondrial
type: Reaction
modifier: MODEL1310110004#

metaM lac D c
constant: false
type: Species
name: (R)-lactate
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16004
is: HMDB01311
has only substance units: false

metaR CHSTEROLt3
type: Reaction
name: cholesterol intracellular transport
reactant: MODEL1310110004#
product: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reversible: true
is: SBO:0000185

metaM HC02214 c
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:28852
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
name: prostaglandin-f1alpha

metaM cholcoar x
type: Species
is: CHEBI:58677
is: HMDB02178
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
name: (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA(4-)
initial amount: NaN
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/p-4/t25-,26-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01348 EHMN_ABBREVIATION: C04760
initial concentration: 1.0

metaM anth e
has only substance units: false
constant: false
type: Species
is: CHEBI:16567
initial concentration: 1.0
boundary condition: false
name: anthranilate
is: HMDB01123
is: SBO:0000247
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
initial amount: NaN

metaM Ser Thr l
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
constant: false
type: Species
is: CHEBI:58190
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00224
name: protein-linked serine or threonine residue (O-glycosylation site)
is: SBO:0000247

metaM m5masnB2 g
type: Species
has only substance units: false
is: CHEBI:58401
initial concentration: 1.0
is: HMDB06814
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C52H87N2O40X CHARGE: 0

metaR 3MOX4HOXPGALDOX
product: MODEL1310110004#
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: false
reactant: MODEL1310110004#

metaR EX doco13ac
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

metaR 3HKYNAKGAT
kinetic law: MODEL1310110004#
reversible: false
fast: false
modifier: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.6.1.7
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
is version of: http://identifiers.org/ec-code/2.6.1.64
is: SBO:0000176

metaR RE0577C
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
name: RE0577
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
reactant: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_ab1e0e97_ad9c_4620_91db_beace980532d
is: B4DKH4
type: Species
has only substance units: false
is encoded by: hsa:1636
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: ACE

metaR G6Pter
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
is described by: ECO:0000269
modifier: MODEL1310110004#
is: SBO:0000185
type: Reaction
product: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
reversible: true

metaR COAtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
name: coenzyme A transport, nuclear

metaR ACACT1r
reversible: true
product: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
name: acetyl-CoA C-acetyltransferase
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_9be50a7c_94cb_485f_9080_655cf1a9ad8b
has part: E9KL44
has part: P55084
constant: false
is encoded by: hsa:3030
is: SBO:0000297
name: HADHA:HADHB
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:3032

http://identifiers.org/biomodels.db/MODEL1310110004#_76f874a5_49d7_4591_b60f_4aa09bf96a22
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7083
name: TK1
initial amount: NaN
has only substance units: false
is: P04183
type: Species
is: SBO:0000252
constant: false

metaR LINKDEG1ly
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
name: degradation of proteoglycan linkage region, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110004#
fast: false
product: MODEL1310110004#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110004#_9547adab_a1e2_4e9e_9787_566594ce3101
initial amount: NaN
constant: false
is encoded by: hsa:1374
is: SBO:0000252
name: CPT1A
has only substance units: false
initial concentration: NaN
is: Q8WZ48
type: Species
boundary condition: true

metaR GCHOLAte
product: MODEL1310110004#
is: SBO:0000185
kinetic law: MODEL1310110004#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
is described by: ECO:0000000
name: bile acid intracellular transport
reactant: MODEL1310110004#

metaR IDOAASE2ly
name: alpha-L-iduronidase, lysosomal
reversible: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.76
is described by: ECO:0000000
kinetic law: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
is: SBO:0000176
fast: false

metaR GCNTg
fast: false
notes: GENE_ASSOCIATION: (2651.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.150 Confidence Level: 4 AUTHORS: PMID:15161861,PMID:8449405 NOTES:NJ
name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
type: Reaction
modifier: MODEL1310110004#
is described by: ECO:0000269
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.150
reactant: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#
kinetic law: MODEL1310110004#

metaM lnlncacoa c
name: alpha-Linolenoyl-CoA
type: Species
is: HMDB06290
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
constant: false
is: CHEBI:51985

metaR COAtm
name: CoA transporter
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
is described by: ECO:0000269
fast: false
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_7726e1f8_95ab_4bc3_9292_2d0957b36a7c
boundary condition: true
name: SGSH
constant: false
initial concentration: NaN
is encoded by: hsa:6448
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: P51688

metaR NACHEXA3ly
is described by: ECO:0000000
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110004#
fast: false
product: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_galacgalfuc12gal14acglcgalgluside_hs_g
type: Species
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
initial amount: NaN
boundary condition: false
is: CHEBI:26174
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_dc3545a9_87ba_4f38_9478_6ba9dbe9e621
boundary condition: true
constant: false
is: Q6FG42
is: SBO:0000252
is encoded by: hsa:4701
initial concentration: NaN
name: NDUFA7
initial amount: NaN
type: Species
has only substance units: false

metaR NDPK10
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false
kinetic law: MODEL1310110004#
is described by: ECO:0000134
reversible: true
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dIDP)
product: MODEL1310110004#

metaM anth c
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:16567
boundary condition: false
type: Species
name: anthranilate
is: HMDB01123
is: SBO:0000247
has only substance units: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108

metaR HMGCOASi
is version of: http://identifiers.org/ec-code/2.3.3.10
product: MODEL1310110004#
is described by: ECO:0000269
fast: false
name: Hydroxymethylglutaryl CoA synthase (ir)
modifier: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
reversible: false

metaM ksi deg23 l
is: CHEBI:12936
name: keratan sulfate I, degradation product 23
is: SBO:0000247
boundary condition: false
is: HMDB00143
constant: false
notes: FORMULA: C124H201N8O106S5 CHARGE: -5
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_ec10f996_7449_44e2_917e_d5b54070d570
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q9BYV1
is encoded by: hsa:64902
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: AGXT2

metaM 3octdece1coa m
type: Species
is: http://identifiers.org/pubchem.compound/5280355
name: 3-hydroxyoctadecenoylcoa
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_e0dd61ef_733f_4653_b579_31cd8d2016c0
is encoded by: hsa:2879
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: P36969
name: GPX4
type: Species
initial amount: NaN

metaR COAtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110004#
is: SBO:0000185
name: coenzyme A transport, peroxisomal
type: Reaction
reactant: MODEL1310110004#
fast: false
reversible: true
kinetic law: MODEL1310110004#

metaR FACOAL246 1
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110004#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
is: SBO:0000176
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true

metaM hs deg3 l
is: SBO:0000247
is: CHEBI:16126
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: heparan sulfate, degradation product 3
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_99544cc7_1b44_4f29_bf02_669da7fab3d4
constant: false
initial amount: NaN
is encoded by: hsa:4724
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: O43181
type: Species
name: NDUFS4

http://identifiers.org/biomodels.db/MODEL1310110004#_5eb8a95b_a46e_432c_81a5_57b676a86521
initial concentration: NaN
is encoded by: hsa:1608
has only substance units: false
boundary condition: true
is: SBO:0000252
is: P49619
initial amount: NaN
type: Species
name: DGKG
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_d8783426_af88_41e4_a57b_3efcf041111e
initial concentration: NaN
is: SBO:0000252
is: B4DK61
is encoded by: hsa:51
type: Species
name: ACOX1
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_849e7c32_69c4_4226_b17c_0328f1a6a613
constant: false
type: Species
is encoded by: hsa:10965
is: SBO:0000252
name: ACOT2
is: P49753
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR PALFATPtc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of Hexadecanoate by the enterocytes
type: Reaction

metaR SO4tl
name: Sulfate transport (lysosome)
reactant: MODEL1310110004#
is described by: ECO:0000269
product: MODEL1310110004#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
kinetic law: MODEL1310110004#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_dd079b03_2a32_43fe_817d_0bc0e5bd09f1
is encoded by: hsa:4701
has only substance units: false
is: Q6FG42
boundary condition: true
constant: false
initial amount: NaN
name: NDUFA7
type: Species
is: SBO:0000252
initial concentration: NaN

metaM 3mox4hoxm m
is: HMDB00291
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
name: 3-Methoxy-4-hydroxymandelate
is: CHEBI:27622

metaM dcholcoa r
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB06292
has only substance units: false
name: chenodeoxycholoyl coenzyme a
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: CHEBI:28701

metaM 3thexddcoacrn c
initial concentration: 1.0
initial amount: NaN
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
has only substance units: false
type: Species
boundary condition: false
constant: false
is: HMDB02014
is: SBO:0000247
notes: FORMULA: C23H41NO5 CHARGE: 0

metaR FAOXC225x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

metaR EX c3dc
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for malonyl carnitine
type: Reaction

metaR SUCCtp
reactant: MODEL1310110004#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
product: MODEL1310110004#
is: SBO:0000185
kinetic law: MODEL1310110004#
name: succinate transporter, peroxisome
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_78b17e06_1dd7_4cce_9aa3_c84ff04aa315
has only substance units: false
is: P09923
name: ALPI
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:248
constant: false

metaR VLCSp
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reversible: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110004#
fast: false
type: Reaction
name: Very-long-chain-fatty-acid-CoA ligase

metaM 3hexdtricoa x
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: HMDB02288
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: 3,7,10-hexadecatrienoylcoa
initial concentration: 1.0
has only substance units: false

metaM 3mop c
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
name: 3-methyl-2-oxopentanoate
constant: false
is: HMDB00491
has only substance units: false
is: CHEBI:28654
is: SBO:0000247
initial amount: NaN

metaR SPHS1Ptr
product: MODEL1310110004#
is: SBO:0000185
fast: false
name: sphingosine-1-phosphate transport
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
kinetic law: MODEL1310110004#

metaR O16G1e
is described by: ECO:0000000
product: MODEL1310110004#
name: oligo-1,6-glucosidase (glygn4 -> glygn5), extracellular
reversible: false
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.10
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#

metaR COAtr
is: SBO:0000185
name: COA transporter, endoplasmic reticulum
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
product: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_5b0c337a_d833_4d1b_af2e_38207f8b6efa
type: Species
is encoded by: hsa:59272
name: ACE2
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: C7ECU1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_ea2c34a6_3c3a_492a_a139_fb043cc10131
initial amount: NaN
name: _D87002_1_m
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:D87002
initial concentration: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_8373a50f_a1a4_433f_8166_e6632c660925
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
name: FUT8
initial amount: NaN
is: A8K8P8
is encoded by: hsa:2530
boundary condition: true
has only substance units: false

metaR ARACHDtr
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
product: MODEL1310110004#
reversible: true
fast: false

metaM mal L e
name: (S)-malate(2-)
is: CHEBI:15589
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
is: HMDB00156
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_72ac208f_3573_47e4_9ad7_aa63a4d081fe
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:1384
is: SBO:0000252
type: Species
name: CRAT
initial concentration: NaN
constant: false

metaM malthp e
is: SBO:0000247
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: C01936
constant: false
type: Species
name: maltoheptaose
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_d4add53d_eea2_4b89_b24b_4c474eb14eed
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: _AI818585_1_c
has only substance units: false
constant: false
is encoded by: hsa:AI818585
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_86999cf0_c2f3_4fef_82ca_60e4d3621fa6
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:4695
constant: false
name: NDUFA2
type: Species
is: O43678
is: SBO:0000252
has only substance units: false

metaM 3ddecdicoa x
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB03952
initial amount: NaN
name: 3,6-dodecadienoylcoa
is: C05280
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
has only substance units: false
type: Species

metaM orn m
boundary condition: false
has only substance units: false
name: Ornithine
type: Species
initial concentration: 1.0
is: C01602
is: HMDB00214
constant: false
is: SBO:0000247
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial amount: NaN
is: CHEBI:46912

metaM urate e
type: Species
name: Urate
constant: false
boundary condition: false
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: C00366
initial concentration: 1.0
is: CHEBI:17775
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00289

metaM ptth m
type: Species
is: HMDB03426
boundary condition: false
is: CHEBI:16753
name: pantetheine
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
constant: false
is: SBO:0000247

metaR ACNACNGALGBSIDEte
fast: false
reversible: true
reactant: MODEL1310110004#
is: SBO:0000185
product: MODEL1310110004#
name: acnacngalgbside hs transport
kinetic law: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ

http://identifiers.org/biomodels.db/MODEL1310110004#_f99c5ffc_9c60_4044_8083_671251b5ad7e
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: _AU149534_1_e
is: SBO:0000252
type: Species
is encoded by: hsa:AU149534
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_604b2055_e01e_43a3_aa5d_7f3319a5d215
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
name: EHHADH
is encoded by: hsa:1962
is: SBO:0000252
has only substance units: false
is: Q9NY65

metaR GTHO
reversible: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
name: glutathione oxidoreductase
is version of: http://identifiers.org/ec-code/1.8.1.7
modifier: MODEL1310110004#
fast: false
type: Reaction
product: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110004#_7b71765c_8391_4c02_9c15_678f0b30f508
constant: false
name: AGPAT5
is encoded by: hsa:55326
is: Q9NUQ2
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR FAOXC141C141OHm
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C14:1OH)m
type: Reaction

metaR GLNtm
is described by: ECO:0000000
reversible: false
name: L-glutamine transport via electroneutral transporter
product: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaM ksii core2 deg9 l
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 9
is: HMDB00143
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:12936
is: SBO:0000247
boundary condition: false
notes: FORMULA: C30H50N3O20X CHARGE: 0

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_26b7d3fc_fd0e_4d81_b793_0884c8aacad7
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
is encoded by: hsa:5315
name: PKM2
initial amount: NaN
is: P14618

metaR 2HCO3 NAt
fast: false
is: SBO:0000185
kinetic law: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110004#
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
reactant: MODEL1310110004#
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_8cfd61d0_5d0f_4d61_b584_bdfc954b0d8b
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:AI769281
initial amount: NaN
name: _AI769281_1_e
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_90943980_4825_4926_8e48_cded0c9c318a
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
name: ADCY5
is: O95622
has only substance units: false
is encoded by: hsa:111

metaR CYTK5n
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110004#
name: cytidylate kinase (CMP),nuclear
fast: false
modifier: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
is described by: ECO:0000269
type: Reaction
product: MODEL1310110004#
reversible: true

metaM mal L c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15589
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
type: Species
has only substance units: false
name: (S)-malate(2-)
is: HMDB00156

metaR DNDPt38m
is: SBO:0000185
reversible: false
type: Reaction
name: dUTP transport via dUDP antiport
reactant: MODEL1310110004#
fast: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000269

metaR ABUTD
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
is: SBO:0000176
name: Aminobutyraldehyde dehydrogenase
fast: false
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_22b0e6ce_7524_4433_95a6_37e1617f51b6
is: Q9NRR6
has only substance units: false
initial concentration: NaN
constant: false
name: INPP5E
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:56623
boundary condition: true
type: Species

metaM CE0849 m
boundary condition: false
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
name: cis,cis-palmito-7,10-dienoyl-CoA
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:57795

http://identifiers.org/biomodels.db/MODEL1310110004#_b7977913_c7e9_45fa_975c_5f9786055101
is: P04745
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:276
name: AMY1A

metaR RE0926E
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
name: RE0926
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110004#
fast: false
type: Reaction
modifier: MODEL1310110004#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.1

http://identifiers.org/biomodels.db/MODEL1310110004#_92f45d79_90ae_469d_89dd_334b0fcea684
has only substance units: false
is: Q99755
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:8394
name: PIP5K1A

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_eb10b5e8_e1d0_415c_b3c7_1a3eb2bb3a26
boundary condition: true
is: O43677
initial concentration: NaN
constant: false
name: NDUFC1
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4717

metaR MANter
name: mannose efflux from endoplasmic reticulum
fast: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110004#
is: SBO:0000185
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_c3495465_63d6_4957_9e2a_80303d07ce8d
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:AD000092
constant: false
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: _AD000092_1_c

metaR FAOXC164m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR r0830
reactant: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reversible: true
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_aa7d44b3_986e_4617_8413_250b8bb0af41
type: Species
has only substance units: false
constant: false
name: TXNRD1
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:7296
boundary condition: true

metaR SUCRe
product: MODEL1310110004#
name: sucrose hydrolyzing enxyme, extracellular
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.20
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.10
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD
reactant: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_76afd1a1_3db0_40f5_bc6c_0b4b37c59553
initial concentration: NaN
constant: false
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: _AA081045_1_m
is encoded by: hsa:AA081045
is: SBO:0000252

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR ACNACNGALGBSIDEtg
is: SBO:0000185
reactant: MODEL1310110004#
reversible: true
product: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
name: acnacngalgbside hs intracellular transport
kinetic law: MODEL1310110004#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_1cd77886_291a_47a8_af59_31c4ddac6055
is encoded by: hsa:158
name: ADSL
has only substance units: false
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_363a204a_a0dd_461f_b113_2cb886c9487e
boundary condition: true
is encoded by: hsa:55568
initial concentration: NaN
constant: false
name: GALNT10
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR AG13T5g
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#

metaR SPHS1Pte
is: SBO:0000185
kinetic law: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
name: sphingosine-1-phosphate transport
fast: false
product: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110004#

metaR r0944
product: MODEL1310110004#
kinetic law: MODEL1310110004#
name: Active transport
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
fast: false

metaM hs deg24 l
is: CHEBI:16126
initial concentration: 1.0
is: SBO:0000247
name: GlcNAc-GlcA-(Gal)2-Xyl
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C31H50NO26 CHARGE: -1
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_664dfa18_418b_4270_b82d_e5b15e983abc
name: PKM2
constant: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5315

http://identifiers.org/biomodels.db/MODEL1310110004#_a1315fe8_7122_45cb_92c8_ab30628ace15
initial amount: NaN
is: Q9GZS9
constant: false
boundary condition: true
initial concentration: NaN
type: Species
name: CHST5
has only substance units: false
is: SBO:0000252
is encoded by: hsa:23563

http://identifiers.org/biomodels.db/MODEL1310110004#_af1de045_3802_4573_8242_36b5978793f0
is: Q13057
is encoded by: hsa:80347
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: COASY

metaR r0085
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
reversible: false
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3

metaM CE2434 m
is: CHEBI:57795
initial amount: NaN
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
has only substance units: false
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false

metaM dodecanac x
initial concentration: 1.0
type: Species
notes: FORMULA: C12H20O4 CHARGE: -2
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: HMDB00623
has only substance units: false
name: Dodecanedioic acid
constant: false

metaR S2TASE1ly
is version of: http://identifiers.org/ec-code/3.1.6.13
modifier: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
type: Reaction
product: MODEL1310110004#
reversible: false
name: iduronate-2-sulfatase, lysosomal
reactant: MODEL1310110004#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_bf266ac3_ae40_4bb9_8f9a_a8ed57a83942
is encoded by: hsa:128869
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is: Q9H490
boundary condition: true
name: PIGU
constant: false

metaR CITtbm
kinetic law: MODEL1310110004#
name: citrate transport, mitochondrial
type: Reaction
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
is: SBO:0000185
is described by: ECO:0000269
fast: false
product: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_f2e4bdda_ac52_4d7c_87f6_40e952f4cd67
name: EHHADH
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q9NY65
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1962

metaM Rtotalcoa c
has only substance units: false
initial concentration: 1.0
is: HMDB01448
name: R total Coenzyme A
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:16189
initial amount: NaN
type: Species
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110004#_f89b955d_534b_4c48_8eae_75f7be51605c
initial amount: NaN
is: SBO:0000252
is: P20674
initial concentration: NaN
constant: false
name: COX5A
is encoded by: hsa:9377
boundary condition: true
type: Species
has only substance units: false

metaR CERT2gt
product: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110004#
reversible: true
name: ceramide transport protein
modifier: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
kinetic law: MODEL1310110004#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.11.1

metaR CSNAT2m
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.7
fast: false
name: carnitine O-aceyltransferase, mitochondrial
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reversible: true
type: Reaction
product: MODEL1310110004#

metaM HC01162 c
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
is: CHEBI:58376

http://identifiers.org/biomodels.db/MODEL1310110004#_70eb7583_ed79_4ebd_a88a_fac02295a96e
is: P30519
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:3163
name: HMOX2
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR r0086
product: MODEL1310110004#
modifier: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.3
kinetic law: MODEL1310110004#
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
fast: false
is: SBO:0000176
reactant: MODEL1310110004#

metaR r2408
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110004#
is: SBO:0000185
type: Reaction
product: MODEL1310110004#
fast: false
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_8889e876_ff92_4c9e_9286_c0369ec2ba9d
is encoded by: hsa:5291
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
boundary condition: true
name: PIK3CB
initial amount: NaN
is: B4DER4

metaM thf c
has only substance units: false
initial concentration: 1.0
is: CHEBI:57453
is: HMDB01846
type: Species
boundary condition: false
is: C00101
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial amount: NaN
constant: false
name: 5,6,7,8-Tetrahydrofolate
is: SBO:0000247

metaM Lkynr c
initial amount: NaN
has only substance units: false
name: L-kynurenine
is: CHEBI:16946
initial concentration: 1.0
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
constant: false
is: SBO:0000247
is: HMDB00684
type: Species
boundary condition: false

metaR KHte
fast: false
is described by: ECO:0000134
product: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: KHte
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110004#

metaM sph1p e
has only substance units: false
initial amount: NaN
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
is: SBO:0000247
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: HMDB01383
is: CHEBI:57939
constant: false
initial concentration: 1.0
boundary condition: false
type: Species

metaR r0720
fast: false
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
reversible: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#

metaR DOLPMT3 Ler
type: Reaction
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110004#
product: MODEL1310110004#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
kinetic law: MODEL1310110004#
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.260

metaM ksi deg25 l
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
name: keratan sulfate I, degradation product 25
is: HMDB01354
has only substance units: false
is: CHEBI:57455
is: SBO:0000247
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
initial amount: NaN

metaR TETTET6COAtx
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185
reversible: true
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
fast: false
is described by: ECO:0000000
name: fatty acid intracellular transport

metaR r0946
reactant: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110004#

metaR IDPtn
is: SBO:0000185
product: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
kinetic law: MODEL1310110004#
type: Reaction
name: IDP nuclear transport
is described by: ECO:0000000
fast: false
reversible: true

metaR r0083
is version of: http://identifiers.org/ec-code/1.1.1.42
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
type: Reaction
product: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#

metaM ksi deg10 l
initial amount: NaN
name: keratan sulfate I, degradation product 10
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
is: CHEBI:57455
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB01354
initial concentration: 1.0

metaM ksi deg36 l
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:12936
type: Species
name: keratan sulfate I, degradation product 36
constant: false
is: SBO:0000247
is: HMDB00143

metaM orn c
name: Ornithine
is: HMDB00214
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: C01602
is: CHEBI:0
constant: false
type: Species

metaR AG13T13g
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110004#
reversible: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR RDH2a
reactant: MODEL1310110004#
name: retinol dehydrogenase (9-cis,NADPH)
is version of: http://identifiers.org/ec-code/1.1.1.105
type: Reaction
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.300
is: SBO:0000176
product: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000269
kinetic law: MODEL1310110004#
reversible: true

metaM urate c
initial concentration: 1.0
is: HMDB00289
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
has only substance units: false
initial amount: NaN
boundary condition: false
name: Urate
is: C00366
is: CHEBI:17775

metaM fru e
is: HMDB00660
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:15824
boundary condition: false
name: D-Fructose
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
is: C00095
type: Species

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_04a083f0_d39e_42e8_bdb7_634793e139da
initial concentration: NaN
name: _AA532636_1_m
constant: false
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:AA532636
is: SBO:0000252
initial amount: NaN

metaR RE1520M
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
is described by: ECO:0000000
name: RE1520
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
modifier: MODEL1310110004#

metaM Ser Thr g
is: HMDB00645
boundary condition: false
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:58336
type: Species
is: SBO:0000247
name: protein-linked serine or threonine residue (O-glycosylation site)

metaM octdececoa m
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
name: octadecenoylcoa
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280355
has only substance units: false
boundary condition: false

metaM gdpfuc g
boundary condition: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: HMDB01095
initial concentration: 1.0
is: CHEBI:57984
initial amount: NaN
name: GDP-L-fucose(2-)
constant: false
has only substance units: false
is: SBO:0000247
type: Species

metaR r0084
modifier: MODEL1310110004#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
reactant: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_811755b6_9b84_4372_b109_5a16d2c14220
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: SLC35A1
is: P78382
constant: false
initial concentration: NaN
is encoded by: hsa:10559
boundary condition: true
type: Species

metaM lnlncacoa m
constant: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
is: HMDB06290
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:51985
type: Species
name: alpha-Linolenoyl-CoA

metaR HSD11B1r
is described by: ECO:0000269
name: 11-beta-hydroxysteroid dehydrogenase type 1
reversible: true
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.1.1.146
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (3290.2) or (3290.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.146 Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
modifier: MODEL1310110004#

metaM HC01609 e
type: Species
name: UroporphyrinogenI
initial amount: NaN
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
initial concentration: 1.0
is: CHEBI:28766
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false

metaM 3octdece1coa c
name: 3-hydroxyoctadecenoylcoa
initial concentration: 1.0
is: SBO:0000247
is: HMDB13336
boundary condition: false
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
type: Species
constant: false
initial amount: NaN
has only substance units: false

metaR BILIRUBtr
type: Reaction
is: SBO:0000185
product: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110004#
fast: false

metaM sph1p c
is: HMDB01383
has only substance units: false
type: Species
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:57939
constant: false

metaR r0940
name: Free diffusion
reversible: true
reactant: MODEL1310110004#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110004#
is: SBO:0000185
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_1e9ca540_f85d_4b81_bbd2_1605f28903ed
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

metaM thf e
type: Species
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
is: HMDB01846
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:57453

http://identifiers.org/biomodels.db/MODEL1310110004#_c2ff8872_b4a5_43a0_960a_d0db84ad6530
boundary condition: true
constant: false
is encoded by: hsa:51227
name: PIGP
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR C101CRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decenoyl carnitine into extra cellular space
type: Reaction

metaR r0409
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.10
kinetic law: MODEL1310110004#
product: MODEL1310110004#
modifier: MODEL1310110004#
name: UTP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110004#_9af8b821_1ba5_4422_a7aa_3718e2b2d12c
initial concentration: NaN
is: Q14432
type: Species
is encoded by: hsa:5139
name: PDE3A
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true

metaR MTHFD2
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
is described by: ECO:0000134
fast: false
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NAD)
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true

metaM fru c
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
is: CHEBI:15824
name: D-Fructose
has only substance units: false
is: HMDB00660
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
initial concentration: 1.0
boundary condition: false
is: C00095

http://identifiers.org/biomodels.db/MODEL1310110004#_92a713ee_7fbe_42c5_b3f8_93af4e59a300
is: SBO:0000252
is: Q7GXY8
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4512
name: COX1
initial concentration: NaN

metaM 3thexddcoacrn e
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB02014
initial amount: NaN
name: 3-hydroxy trans7,10-hexadecadienoyl carnitine
constant: false
notes: FORMULA: C23H41NO5 CHARGE: 0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_99b10694_2b5c_4734_9f88_c468563004b5
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
name: SLC23A1
boundary condition: true
is: Q9UHI7
is encoded by: hsa:9963
initial amount: NaN
type: Species

metaM orn e
initial amount: NaN
is: HMDB00214
is: SBO:0000247
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: CHEBI:0
has only substance units: false
is: C01602
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
name: Ornithine

http://identifiers.org/biomodels.db/MODEL1310110004#_ff9365b1_72df_4473_bea8_90e88df14d41
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: HADHB
is encoded by: hsa:3032
is: P55084
type: Species
initial amount: NaN

metaM mal L m
is: SBO:0000247
is: HMDB00156
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: CHEBI:15589
has only substance units: false
boundary condition: false
initial amount: NaN
name: (S)-malate(2-)

metaR FAS140COA
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
reversible: false
product: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty-acyl-CoA synthase (n-C14:0CoA)
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110004#_9278d9d8_5ff1_48e7_99c5_320fcb1c7ce3
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
is: G3V0F6
name: DGKZ
is encoded by: hsa:8525
has only substance units: false

metaR GDPtg
kinetic law: MODEL1310110004#
is described by: ECO:0000000
reversible: true
product: MODEL1310110004#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
name: GDP intracellular transport
fast: false

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR DM gpi sig er
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR ALAGLNexR
is: SBO:0000185
modifier: MODEL1310110004#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
name: L-alanine/glutamine reversible exchange
reversible: true
fast: false
product: MODEL1310110004#
type: Reaction

metaR B3GNT310g
fast: false
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000254
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
type: Reaction

metaR r0407
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/1.4.3.5
type: Reaction
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
is: SBO:0000176
fast: false
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_82fc690a_f5ee_42a2_b744_e865dd805cf5
name: HSD3B2
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: P26439
has only substance units: false
is encoded by: hsa:3284

metaM nicrnt c
constant: false
is: C01185
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
name: Nicotinate D-ribonucleotide
is: HMDB01132
boundary condition: false
is: CHEBI:57502
has only substance units: false
is: SBO:0000247

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_822a1cb8_ce35_4b15_a3c2_11ccb286c3c0
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:5742
is: P23219
is: SBO:0000252
name: PTGS1

metaR r0942
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110004#
type: Reaction
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
fast: false
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_84078c83_1d69_4652_ade1_e5687c3e768e
is: SBO:0000252
is: Q8IYH3
constant: false
name: HAS1
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:3036
has only substance units: false

metaM HC01408 m
name: 3-Oxohexanoyl-CoA
is: CHEBI:27648
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaR r0408
fast: false
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:
reactant: MODEL1310110004#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.3.5
kinetic law: MODEL1310110004#
type: Reaction
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
product: MODEL1310110004#
is: SBO:0000176
modifier: MODEL1310110004#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_3b37e3f8_b3ca_4b90_84ba_820265ea4ff4
is: SBO:0000252
is encoded by: hsa:5296
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PIK3R2
constant: false
type: Species
is: O00459
boundary condition: true

metaR ACITL
reversible: false
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110004#
name: ATP-Citrate lyase
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.8
fast: false
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_d7139d74_749c_4de6_92e4_2bfe0a1fac3c
is: SBO:0000252
is: P08236
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2990
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: GUSB

http://identifiers.org/biomodels.db/MODEL1310110004#_6190084e_d12e_44b2_84de_30e859183a8e
name: RPN1
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:6184
boundary condition: true
constant: false
is: P04843
has only substance units: false
initial amount: NaN

metaM 3ddecdicoa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
type: Species
boundary condition: false
has only substance units: false
name: 3,6-dodecadienoylcoa
initial concentration: 1.0
initial amount: NaN
is: C05280
constant: false
is: SBO:0000247
is: HMDB03952

http://identifiers.org/biomodels.db/MODEL1310110004#_96fa00b6_6997_4100_af3b_5757e3c3811c
boundary condition: true
is: G5E960
name: PLCB3
type: Species
initial amount: NaN
is encoded by: hsa:5331
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN

metaR AHEXASE2ly
product: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110004#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is: SBO:0000176

metaR SO4t4 2
fast: false
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
name: sulfate transport via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110004#_c8458ce4_fe34_4f47_8353_21a6b0a7bd7d
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI024818
is: SBO:0000252
boundary condition: true
constant: false
name: _AI024818_1_c
type: Species

metaM 13dampp c
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
is: SBO:0000247
is: CHEBI:57484
boundary condition: false
type: Species
name: trimethylenediaminium
initial amount: NaN
constant: false
is: HMDB00002
initial concentration: 1.0
has only substance units: false

metaR r0717
is described by: ECO:0000000
product: MODEL1310110004#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110004#
reversible: false
kinetic law: MODEL1310110004#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17

metaR ALADGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000185
product: MODEL1310110004#
reversible: true
fast: false
is described by: ECO:0000304
name: D-alanine/glycine reversible exchange
type: Reaction
kinetic law: MODEL1310110004#

metaM acglcgal14acglcgalgluside hs g
boundary condition: false
is: SBO:0000247
name: nLc5Cer
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
constant: false
has only substance units: false
is: CHEBI:17103
type: Species

metaR HPDCACRNCPT1
fast: false
notes: GENE_ASSOCIATION: (1375.2) or (1375.3) or (1374.1) or (126129.1) or (1375.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110004#
product: MODEL1310110004#
name: carnitine fatty-acyl transferase
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_b543650e_b831_449b_a65a_9908a6cbbd9c
is: SBO:0000252
type: Species
is: P51160
constant: false
has only substance units: false
is encoded by: hsa:5146
initial concentration: NaN
boundary condition: true
name: PDE6C
initial amount: NaN

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR CDSm
is: SBO:0000176
fast: false
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ
is described by: ECO:0000000
reactant: MODEL1310110004#
name: phosphatidate cytidylyltransferase
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.41
product: MODEL1310110004#
modifier: MODEL1310110004#

metaM pmtcoa c
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
is: HMDB01338
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
is: SBO:0000247
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:3454

metaM dmnoncrn x
is: HMDB06202
notes: FORMULA: C18H37NO4 CHARGE: 0
has only substance units: false
boundary condition: false
initial amount: NaN
name: 4,8-dimethylnonanoyl carnitine
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_176622f9_86ea_4a12_b2f1_d53a1eab2234
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: O43306
name: ADCY6
is encoded by: hsa:112

metaM 3thexddcoa c
is: SBO:0000247
initial concentration: 1.0
name: 3-hydroxy trans7,10-hexadecadienoylcoa
type: Species
is: HMDB02014
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C37H58N7O18P3S CHARGE: -4

metaM acgam l
is: SBO:0000247
is: CHEBI:17411
constant: false
has only substance units: false
name: N-acetyl-D-glucosamine
is: HMDB00215
initial amount: NaN
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_e37e5195_9ecc_4ed2_b607_a3ecdb3b9490
type: Species
name: PRDX2
is encoded by: hsa:7001
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_42de13b7_af6a_40df_b58c_0f1b9e0050e2
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3242
name: HPD
boundary condition: true
initial amount: NaN
is: B3KQ63

metaR GCHOLAtx
type: Reaction
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
fast: false
reversible: true
is described by: ECO:0000000

metaM dcmp n
is: HMDB01202
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: CHEBI:57566
name: dCMP(2-)

http://identifiers.org/biomodels.db/MODEL1310110004#_a3b0ae56_27df_4f5c_9ae8_482606ff052b
name: ADCY10
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55811
initial amount: NaN
constant: false
has only substance units: false
is: F5GWS5
type: Species

metaM ksi pre8 g
name: keratan sulfate I biosynthesis, precursor 8
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
is: CHEBI:28067
has only substance units: false
boundary condition: false
type: Species
constant: false
is: SBO:0000247

metaR r0829
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
type: Reaction
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/4.1.1.37
is: SBO:0000185
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_3f207a40_f0bd_4c6f_ba6b_836cdd7c1916
constant: false
is encoded by: hsa:1376
is: P23786
type: Species
name: CPT2
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR DM ethamp r
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR SPMTDe
name: SPMTDe
product: MODEL1310110004#
is described by: ECO:0000134
reactant: MODEL1310110004#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110004#
fast: false

metaR r0716
kinetic law: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#
type: Reaction
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110004#
reversible: false

metaR HPDCACRNCPT2
reactant: MODEL1310110004#
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110004#
reversible: false
is: SBO:0000176
type: Reaction
name: heptadecanoate transport into the mitochondria

metaR GLUt7l
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
reversible: false
product: MODEL1310110004#
name: Glutamate transport, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaM HC00900 m
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
has only substance units: false
initial amount: NaN
type: Species
constant: false
name: Methylmalonate
boundary condition: false
is: CHEBI:30860

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_acgalfucgalacglcgal14acglcgalgluside_hs_g
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C72H125N4O41FULLRCO CHARGE: 0
initial concentration: 1.0
has only substance units: false
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
is: CHEBI:61648

http://identifiers.org/biomodels.db/MODEL1310110004#_e65f7ea7_91d1_42fd_aca5_34a82565355a
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: SDHD
initial concentration: NaN
is encoded by: hsa:6392
is: O14521

metaR ALDD2xm
fast: false
is described by: ECO:0000134
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
type: Reaction
reversible: false
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176

metaM ksii core2 deg2 l
is: CHEBI:12936
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 2
is: SBO:0000247
boundary condition: false
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
constant: false
type: Species
is: HMDB00143

metaM dhcholestanate m
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:16577
initial concentration: 1.0
is: HMDB00359
is: SBO:0000247
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate

metaR MTHFCm
is version of: http://identifiers.org/ec-code/3.5.4.9
is: SBO:0000176
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
fast: false
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.3.4.3
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_08f7cf4c_757a_48b3_af11_ba255d774e4e
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8854
initial amount: NaN
is: B4DZR2
is: SBO:0000252
name: ALDH1A2
boundary condition: true
type: Species
constant: false

metaR OCD11COACPT1
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

metaM adp n
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: HMDB01341
has only substance units: false
constant: false
is: SBO:0000247
name: ADP(3-)
type: Species

metaM btamp c
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:3110
initial concentration: 1.0
is: HMDB04220
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
has only substance units: false
name: Biotinyl-5'-AMP
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_1a990f58_afed_41a0_a444_77d59906b842
boundary condition: true
name: PRDX2
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:7001
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR ACGAMtly
product: MODEL1310110004#
reversible: false
reactant: MODEL1310110004#
fast: false
is: SBO:0000185
name: N-acetyl-glucosamine lysosomal efflux
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
is described by: ECO:0000000
type: Reaction

metaR r0715
is version of: http://identifiers.org/ec-code/6.3.2.5
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
product: MODEL1310110004#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
modifier: MODEL1310110004#

metaM gly x
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
name: glycine
constant: false
is: CHEBI:15428
is: HMDB00123
is: SBO:0000247
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_37d33767_4af4_4441_b4d0_5d5202957047
initial amount: NaN
type: Species
initial concentration: NaN
is: Q9NVE7
boundary condition: true
is: SBO:0000252
name: PANK4
has only substance units: false
constant: false
is encoded by: hsa:55229

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaM prostgi2 e
is: CHEBI:57403
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
name: prostaglandin I2(1-)
initial amount: NaN
constant: false
is: HMDB01335
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312

metaR LEUt5m
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
name: leucine mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
kinetic law: MODEL1310110004#

metaR RE3346C
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
reversible: true
kinetic law: MODEL1310110004#
product: MODEL1310110004#
name: RE3346
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_80da3104_5349_48b7_a9fc_e30054e0cbdb
initial concentration: NaN
name: _AI378339_1_m
initial amount: NaN
is encoded by: hsa:AI378339
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_8eedb3f7_4370_4f73_a65f_27de1d385c34
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: O14734
is encoded by: hsa:10005
name: ACOT8
is: SBO:0000252
constant: false

metaR 5ADTSTSTERONEtr
is: SBO:0000185
type: Reaction
product: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
is described by: ECO:0000000
name: 5 alpha dihydrotesterone intracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaM adp m
is: CHEBI:456216
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C00008
constant: false
is: SBO:0000247
is: HMDB01341
is: http://identifiers.org/pubchem.compound/3310
type: Species
initial amount: NaN
name: ADP

metaR r0714
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
product: MODEL1310110004#
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110004#

metaM hs deg19 l
is: HMDB01352
is: SBO:0000247
initial amount: NaN
is: CHEBI:17180
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
name: heparan sulfate, degradation product 19
has only substance units: false

metaM c6dc x
constant: false
initial concentration: 1.0
boundary condition: false
name: adipoyl carnitine
has only substance units: false
type: Species
is: HMDB04047
initial amount: NaN
notes: FORMULA: C13H22NO6 CHARGE: -1
is: SBO:0000247
is: C14143

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_fucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)2 (Cer)1
constant: false
is: CHEBI:61648
is: SBO:0000247

metaM xylu L c
name: L-xylulose
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17399
is: HMDB00751
constant: false
boundary condition: false

metaM e4hglu m
has only substance units: false
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: CHEBI:6331
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: HMDB02273
name: erythro-4-hydroxy-L-glutamate(1-)
boundary condition: false
is: SBO:0000247

metaM lald D c
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: HMDB06458
name: (R)-lactaldehyde
is: CHEBI:17167
constant: false

metaR GALASE10ly
type: Reaction
reactant: MODEL1310110004#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR PROSTGD2t
fast: false
is: SBO:0000185
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
product: MODEL1310110004#
type: Reaction
reversible: true
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110004#
is described by: ECO:0000269
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_7a1e946a_b3e9_4cab_baed_8c99deecd061
is: SBO:0000252
name: ATP2B3
initial concentration: NaN
constant: false
is: Q16720
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:492
initial amount: NaN

metaR RE2998M
reactant: MODEL1310110004#
name: RE2998
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110004#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
fast: false
type: Reaction

metaR NADS2
is version of: http://identifiers.org/ec-code/6.3.5.1
type: Reaction
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110004#
name: NAD synthase (glutamine-hydrolysing)
reversible: false
product: MODEL1310110004#
is described by: ECO:0000269
modifier: MODEL1310110004#
is: SBO:0000176
fast: false

metaR DHCRD1
modifier: MODEL1310110004#
is: SBO:0000176
fast: false
reactant: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
reversible: false
name: dihydroceramide desaturase
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110004#

metaR THYOXt2
type: Reaction
kinetic law: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
fast: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110004#
name: T4 transport via facilitated diffusion
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110004#_d02443fe_4390_40ec_8689_5a21ec308250
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:AA502753
has only substance units: false
name: _AA502753_1_m
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_b1c9036e_dd24_4aea_9e21_c36e99342bbe
name: NME1
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:4830
initial concentration: NaN

metaM stcoa m
initial amount: NaN
is: HMDB01114
is: C00412
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
name: Stearoyl-CoA (n-C18:0CoA)
boundary condition: false
is: SBO:0000247
is: CHEBI:57394
constant: false

metaR r0638
is version of: http://identifiers.org/ec-code/2.8.1.2
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
reversible: true
product: MODEL1310110004#
is described by: ECO:0000000
modifier: MODEL1310110004#
fast: false
type: Reaction
is: SBO:0000176

metaM Ser Gly Ala X Gly l
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
type: Species
name: protein-linked serine residue (glycosaminoglycan attachment site)
is: SBO:0000247
is: HMDB02183
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:36005
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_d47119e2_2db3_4a1b_ab6b_b0e843b45f24
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: PPAP2B
type: Species
is: O14495
is encoded by: hsa:8613
has only substance units: false
initial amount: NaN

metaR CITtam
type: Reaction
name: citrate transport, mitochondrial
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_galacglc13galacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
type: Species
has only substance units: false
name: nLc8Cer
is: SBO:0000247
is: CHEBI:26174

metaR r1492
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
name: Utilized transport
reactant: MODEL1310110004#
fast: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_0e107b60_570a_450f_8e72_4e05f9e352f7
is encoded by: hsa:522
constant: false
type: Species
is: SBO:0000252
name: ATP5J
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM CE1944 c
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:36781
name: 1-pyrrolinium
initial amount: NaN

metaM n2m2masn g
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C11530
notes: FORMULA: C50H83N4O35X CHARGE: 0
constant: false
initial concentration: 1.0
boundary condition: false
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
type: Species

metaM ksii core2 deg8 l
initial concentration: 1.0
name: keratan sulfate II (core 2-linked), degradation product 8
has only substance units: false
is: SBO:0000247
is: CHEBI:12936
initial amount: NaN
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: HMDB00143
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_6a0699d2_c741_41ff_a903_1148e89d5188
is: P11310
boundary condition: true
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:34
initial amount: NaN
is: SBO:0000252
name: ACADM

metaM nad c
is: HMDB00902
is: C00003
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/3305
has only substance units: false
name: Nicotinamide adenine dinucleotide
boundary condition: false
is: CHEBI:57540
type: Species
initial concentration: 1.0
is: SBO:0000247

metaM pmtcrn c
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:17490
constant: false
is: SBO:0000247
is: HMDB00222
name: L-palmitoylcarnitine
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial concentration: 1.0
type: Species

metaR DLNLCGt
fast: false
kinetic law: MODEL1310110004#
is described by: ECO:0000000
product: MODEL1310110004#
reversible: true
name: fatty acid transport via diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110004#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110004#_c54c9c0b_c712_45ee_8985_c21d137c48f6
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
constant: false
name: SLC5A3
is encoded by: hsa:6526
is: P53794
is: SBO:0000252

metaR NACHEXA21ly
kinetic law: MODEL1310110004#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
product: MODEL1310110004#
modifier: MODEL1310110004#
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110004#
type: Reaction

metaM trdrd m
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:15967
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: Reduced thioredoxin
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
type: Species

metaR ASNtN1
type: Reaction
name: Asparagine transport (Na, H coupled)
is described by: ECO:0000269
product: MODEL1310110004#
modifier: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000185
kinetic law: MODEL1310110004#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_eff7e55c_e15f_4152_ad7a_b32123d57282
is: SBO:0000252
is: P50225
initial amount: NaN
is encoded by: hsa:6817
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: SULT1A1

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

metaM o2s x
type: Species
has only substance units: false
is: HMDB02168
name: superoxide
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial concentration: 1.0
is: CHEBI:18421
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false

metaR C121CPT1
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecenoylcarnitine
type: Reaction

metaM CE5854 e
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
is: SBO:0000247
has only substance units: false
is: HMDB02710
name: gama-CEHC-glucuronide
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:27485

http://identifiers.org/biomodels.db/MODEL1310110004#_730cb3d7_db26_4aa6_8cec_b12f5750241c
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
name: _H45672_1_m
initial amount: NaN
constant: false
is encoded by: hsa:H45672

http://identifiers.org/biomodels.db/MODEL1310110004#_fa8afdd2_ec80_463d_ab8d_0de733ff2cd4
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ALDH9A1
type: Species
initial concentration: NaN
constant: false
is: P49189
is encoded by: hsa:223

metaR CMPACNAtg
kinetic law: MODEL1310110004#
name: CMP-Sia Golgi transport via CMP antiport
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
reversible: true
fast: false

metaM gln L m
is: HMDB00641
is: CHEBI:18050
initial concentration: 1.0
constant: false
is: SBO:0000247
name: L-glutamine
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_c5aa9956_e561_45f6_961f_b2e0c08623d4
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:30833
type: Species
has only substance units: false
name: NT5C
is: Q8TCD5
initial concentration: NaN

metaM acgam e
initial concentration: 1.0
name: N-acetyl-D-glucosamine
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:17411

metaR r2000
is described by: ECO:0000000
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
is: SBO:0000185
reactant: MODEL1310110004#
fast: false
type: Reaction
kinetic law: MODEL1310110004#

metaR RE1845C
kinetic law: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
name: RE1845
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110004#
product: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
reversible: true

metaM eicostetcoa m
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
boundary condition: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
initial concentration: 1.0
has only substance units: false
is: C16164
name: eicosatetranoyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110004#_88c7804e_0ca2_4cae_82fe_83038e86e6f7
constant: false
is encoded by: hsa:8818
name: DPM3:DPM1:DPM2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:54344
has only substance units: false
is: SBO:0000297
boundary condition: true
type: Species
has part: Q9P2X0

http://identifiers.org/biomodels.db/MODEL1310110004#_67d63a32_8883_4e6b_a7a7_6b5abdb507c2
is: SBO:0000252
type: Species
initial amount: NaN
name: PLCE1
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:51196
constant: false
is: Q9P212

metaR r0639
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110004#
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
kinetic law: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
fast: false

metaR PI4PP
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2425833 NOTES:NCD
name: phosphatidylinositol-4-phosphate 4-phosphatase
reversible: false

metaM 3dsphgn c
is: HMDB01480
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
initial concentration: 1.0
is: CHEBI:58299
boundary condition: false
type: Species
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_9e77e0dd_97a2_4ba5_979c_6567108f6561
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: P03905
constant: false
name: ND4
is: SBO:0000252
is encoded by: hsa:4538
initial amount: NaN

metaM nad m
constant: false
is: CHEBI:57540
name: Nicotinamide adenine dinucleotide
is: SBO:0000247
is: HMDB00902
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3305
is: C00003
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_509e0964_ba0c_4f70_b057_7114595c3493
boundary condition: true
has only substance units: false
name: INPPL1
type: Species
initial amount: NaN
is: SBO:0000252
is: O15357
initial concentration: NaN
is encoded by: hsa:3636
constant: false

metaR SQLEr
reversible: false
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
product: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.132
name: Squalene epoxidase, endoplasmic reticular (NADP)
modifier: MODEL1310110004#

metaM adp x
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:456216
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
constant: false
name: ADP(3-)
is: HMDB01341
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_653cc2d0_4c3c_418e_8a9b_ef80e25a9d67
is: B7Z3W8
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:6536
is: SBO:0000252
boundary condition: true
name: SLC6A9
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_b6c86a81_5502_4841_be3e_03d6db5e4c84
initial concentration: NaN
name: FUT8
boundary condition: true
is encoded by: hsa:2530
is: SBO:0000252
type: Species
is: G3V5N0
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_464fec04_6ccb_4df8_9d73_57835e9162a4
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:D87002
is: SBO:0000252
constant: false
initial amount: NaN
name: _D87002_1_e
boundary condition: true

metaM acgam1p c
initial concentration: 1.0
constant: false
name: N-Acetyl-D-glucosamine 1-phosphate
is: SBO:0000247
is: CHEBI:7125
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
is: HMDB01367
type: Species
has only substance units: false

metaM pheme c
boundary condition: false
type: Species
name: Protoheme
has only substance units: false
constant: false
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
is: CHEBI:17627
is: SBO:0000247
is: HMDB03178
initial amount: NaN
initial concentration: 1.0
is: C00032

metaM ppi x
initial amount: NaN
has only substance units: false
constant: false
is: C00013
name: Diphosphate
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
is: HMDB00250
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_69dba68c_297c_4bc5_a130_fde4ac970379
constant: false
is encoded by: hsa:8704
initial amount: NaN
name: B4GALT2
boundary condition: true
has only substance units: false
initial concentration: NaN
is: O60909
is: SBO:0000252
type: Species

metaR FAOXC143C123x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)x
type: Reaction

metaR RE0691C
is: SBO:0000176
product: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
name: RE0691
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:

metaR AMPtp
kinetic law: MODEL1310110004#
reversible: true
is: SBO:0000185
product: MODEL1310110004#
is described by: ECO:0000000
name: AMP transporter, peroxisome
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
reactant: MODEL1310110004#
type: Reaction

metaM orot5p c
initial amount: NaN
is: HMDB00218
is: SBO:0000247
is: CHEBI:57538
boundary condition: false
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
is: C01103
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
name: Orotidine 5'-phosphate

metaR r0822
kinetic law: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110004#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaM HC00822 l
is: CHEBI:28681
type: Species
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: Chitobiose
boundary condition: false

metaR r1052
reversible: false
product: MODEL1310110004#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Vesicular transport
fast: false
reactant: MODEL1310110004#

metaR FACOAL2252
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000269
product: MODEL1310110004#
type: Reaction
is: SBO:0000176
name: fatty-acid--CoA ligase
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false

metaM taur x
has only substance units: false
is: CHEBI:15891
name: taurine
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
type: Species
is: HMDB00251
initial concentration: 1.0
constant: false

metaM nh4 n
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
is: SBO:0000247
name: ammonium
initial amount: NaN
type: Species
is: CHEBI:28938
initial concentration: 1.0
constant: false
has only substance units: false

metaM gln L c
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
name: L-glutamine
is: HMDB00641
is: CHEBI:18050
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
has only substance units: false
initial concentration: 1.0

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaM air c
has only substance units: false
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
is: HMDB01235
is: CHEBI:58592
initial concentration: 1.0
boundary condition: false
is: C03373
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
initial amount: NaN

metaM andrstandn r
name: 5alpha-androstane-3,17-dione
constant: false
initial concentration: 1.0
is: CHEBI:15994
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
initial amount: NaN
type: Species
is: HMDB00899
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR COAtg
type: Reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000000
name: CoA transport in Golgi via diffusion
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185

metaR r2006
product: MODEL1310110004#
reversible: false
reactant: MODEL1310110004#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110004#

metaM acgam c
is: CHEBI:17411
name: N-acetyl-D-glucosamine
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
has only substance units: false
type: Species
initial concentration: 1.0
constant: false

metaR r1051
is: SBO:0000185
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
name: Vesicular transport
type: Reaction
fast: false
reactant: MODEL1310110004#
is described by: ECO:0000000
reversible: true
product: MODEL1310110004#

metaR r0821
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110004#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
type: Reaction
modifier: MODEL1310110004#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110004#
is described by: ECO:0000000

metaR CYSGLYexR
reversible: true
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
name: L-cysteine/glycine reversible exchanger
reactant: MODEL1310110004#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
product: MODEL1310110004#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_e5193505_0ca0_454f_ae3a_c3518807c0e4
boundary condition: true
is: Q9UFY1
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5335
initial amount: NaN
name: PLCG1
type: Species

metaR TRDR
is version of: http://identifiers.org/ec-code/1.8.1.9
reactant: MODEL1310110004#
reversible: false
type: Reaction
modifier: MODEL1310110004#
is described by: ECO:0000269
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
product: MODEL1310110004#
name: thioredoxin reductase (NADPH)
fast: false
is: SBO:0000176

metaM pheme e
has only substance units: false
is: C00032
name: Protoheme
initial amount: NaN
type: Species
notes: FORMULA: C34H30FeN4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00041 EHMN_ABBREVIATION: C00032
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB03178
is: CHEBI:17627

metaR r0410
is: SBO:0000176
type: Reaction
product: MODEL1310110004#
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
is described by: ECO:0000000
reactant: MODEL1310110004#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
kinetic law: MODEL1310110004#

metaM pa hs n
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
name: phosphatidate(2-)
is: CHEBI:57739
is: SBO:0000247

metaM dcholcoa x
is: HMDB06292
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: SBO:0000247
boundary condition: false
name: chenodeoxycholoyl coenzyme a
is: CHEBI:28701
constant: false

metaM pmtcoa m
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: C00154
constant: false
is: HMDB01338
type: Species
initial amount: NaN
initial concentration: 1.0
name: Palmitoyl-CoA (n-C16:0CoA)
boundary condition: false
is: CHEBI:57379
is: SBO:0000247

metaM dcmp c
name: dCMP
has only substance units: false
is: HMDB01202
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:57566
is: C00239
boundary condition: false
type: Species
constant: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239

metaR FPGSm
reactant: MODEL1310110004#
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/6.3.2.17
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
kinetic law: MODEL1310110004#
product: MODEL1310110004#
name: folylpolyglutamate synthetase, mitochondrial
modifier: MODEL1310110004#
is: SBO:0000176

metaM gluala e
type: Species
name: 5-L-Glutamyl-L-alanine
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C03740
is: HMDB06248
is: http://identifiers.org/pubchem.compound/6503
constant: false
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
initial amount: NaN
is: SBO:0000247

metaR r1384
type: Reaction
is: SBO:0000176
product: MODEL1310110004#
name: Guanosine aminohydrolase EC:3.5.4.15
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:
fast: false
reactant: MODEL1310110004#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_846ef896_bfe3_4496_abdb_f577dc643d9a
type: Species
initial concentration: NaN
is encoded by: hsa:27159
name: CHIA
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: A8K3T7
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_1b9408bc_05dd_4793_91db_3cf6dd20f7b5
is encoded by: hsa:7108
initial amount: NaN
is: SBO:0000252
is: O76062
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false
name: TM7SF2

metaR C12DCTD
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_2ea229fe_d11a_48cc_9964_0e4a674bf183
boundary condition: true
has only substance units: false
type: Species
name: PLCB4
constant: false
initial amount: NaN
is encoded by: hsa:5332
initial concentration: NaN
is: SBO:0000252
is: E2QRH8

metaM HC00900 c
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
name: Methylmalonate
boundary condition: false
is: CHEBI:30860
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_8ac69f90_3d68_4160_9bed_5d44d41fc4cf
boundary condition: true
constant: false
is: SBO:0000297
initial concentration: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has part: P37287
initial amount: NaN
has only substance units: false
is encoded by: hsa:8818
type: Species
is encoded by: hsa:5277

metaR EX fe2 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: EX_fe2(u)
type: Reaction

metaR FACOAL2251
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
kinetic law: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000176
modifier: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
name: fatty-acid--CoA ligase

metaM dhcholestanate x
initial amount: NaN
has only substance units: false
is: CHEBI:16577
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
type: Species
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate

http://identifiers.org/biomodels.db/MODEL1310110004#_c74d8537_6ffe_4c2a_90b9_6a7656b5125d
type: Species
initial concentration: NaN
name: GALNT11
boundary condition: true
is: B3KWF4
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:63917

metaR NMNATr
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110004#
type: Reaction
name: nicotinamide-nucleotide adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.7.1
is described by: ECO:0000269
reversible: true
product: MODEL1310110004#
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_42f02a6b_3efa_4755_a2e1_be2d57edada8
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
is: Q92523
name: CPT1B
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1375

metaR MMSAD1m
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.27
name: methylmalonate-semialdehyde dehydrogenase
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
reactant: MODEL1310110004#
product: MODEL1310110004#
modifier: MODEL1310110004#

metaR 5ADTSTSTERONEte
name: 5 alpha dihydrotesterone transport
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110004#
product: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaR SARCStm
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
reversible: false
is described by: ECO:0000000
name: Sarcosine transport (mitochondrial)
type: Reaction
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
product: MODEL1310110004#

metaM btamp m
initial amount: NaN
is: CHEBI:3110
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: Biotinyl-5'-AMP
is: HMDB04220

http://identifiers.org/biomodels.db/MODEL1310110004#_504ffa29_a696_4d65_9fb4_a9b83c9cdc7f
name: RRM2
initial amount: NaN
constant: false
is encoded by: hsa:6241
initial concentration: NaN
type: Species
is: P31350
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM trdrd c
boundary condition: false
name: Reduced thioredoxin
is: SBO:0000247
constant: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
is: C00342
is: CHEBI:15967
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaM ksi pre35 g
type: Species
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 35
initial amount: NaN
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
is: CHEBI:28067
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR CSND
fast: false
product: MODEL1310110004#
name: Cytosine deaminase
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_f84e90b9_c3c6_492c_9f1d_5cb839a37f38
has only substance units: false
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: B3KT86
initial concentration: NaN
name: ADCY3
is: SBO:0000252
is encoded by: hsa:109

metaR FADDPle
reactant: MODEL1310110004#
is: SBO:0000176
fast: false
name: FAD diphosphatase
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/3.1.4.1
product: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reversible: false
type: Reaction
is described by: ECO:0000134

metaM 3odcoa m
is: SBO:0000247
is: CHEBI:28528
boundary condition: false
constant: false
has only substance units: false
is: HMDB03939
initial concentration: 1.0
name: 3-Oxodecanoyl-CoA
initial amount: NaN
type: Species
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265

metaR TSULt4 3
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
fast: false
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
reactant: MODEL1310110004#
modifier: MODEL1310110004#
name: thiosulfate transport via sodium symport

http://identifiers.org/biomodels.db/MODEL1310110004#_58a19ede_a72a_41d9_8ec0_f724546302df
is: SBO:0000252
is encoded by: hsa:84735
has only substance units: false
initial amount: NaN
constant: false
is: Q96KN2
type: Species
initial concentration: NaN
boundary condition: true
name: CNDP1

metaR RE3624M
name: RE3624
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000

metaR G14T19g
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_fucgalacglcgal14acglcgalgluside_hs_g
type: Species
has only substance units: false
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
initial concentration: 1.0
name: VI2Fuc-nLc6
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:61648
boundary condition: false

metaR DHPR
is described by: ECO:0000269
name: 6,7-dihydropteridine reductase
is version of: http://identifiers.org/ec-code/1.5.1.34
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.6.99.7 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:
type: Reaction

metaR GLCAASE8ly
reactant: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is described by: ECO:0000269
reversible: false
product: MODEL1310110004#
name: beta-glucuronidase, lysosomal
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.31

http://identifiers.org/biomodels.db/MODEL1310110004#_e08d79f7_e077_4527_a28a_0109540bfc22
is: P42336
boundary condition: true
is encoded by: hsa:5290
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: PIK3CA
initial concentration: NaN

metaM dgpi prot hs r
has only substance units: false
is: HMDB02925
name: deacylated-glycophosphatidylinositol (GPI)-anchored protein
is: CHEBI:53486
constant: false
notes: FORMULA: C39H76N4O37P4FULLRCO2FULLR2CO2X CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species

metaR r2420
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110004#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
product: MODEL1310110004#

metaM pa hs m
initial amount: NaN
name: phosphatidate(2-)
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
constant: false
is: SBO:0000247
is: CHEBI:57739
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species

metaR PItg
is: SBO:0000185
product: MODEL1310110004#
name: phosphate transport, Golgi apparatus
fast: false
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaM adp r
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:456216
name: ADP(3-)
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: HMDB01341
constant: false

metaR EX 3octdeccrn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyoctadecanoyl carnitine
type: Reaction

metaM mescon m
is: HMDB00749
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
name: Mesaconate
is: CHEBI:36986

metaM dec47dicoa x
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
name: 4,7-decadienoylcoa
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

metaR C102CPT1
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaM nh4 m
has only substance units: false
is: HMDB00051
name: Ammonium
constant: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
is: C01342
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:28938
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_abbaff65_daa5_4aa5_8be1_39149c2d1fc5
type: Species
initial amount: NaN
boundary condition: true
name: SLCO1B1
has only substance units: false
initial concentration: NaN
is: Q9Y6L6
is encoded by: hsa:10599
constant: false
is: SBO:0000252

metaR r1380
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
product: MODEL1310110004#

metaM q10 m
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
name: ubiquinone-10
initial amount: NaN
is: HMDB01072
boundary condition: false
is: CHEBI:46245
is: SBO:0000247

metaR DHORD9
is version of: http://identifiers.org/ec-code/1.3.5.2
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
type: Reaction
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185
name: dihydoorotic acid dehydrogenase (quinone10)
reversible: false
reactant: MODEL1310110004#
is described by: ECO:0000269
fast: false
product: MODEL1310110004#

metaR FAOXC164x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

metaM gln L e
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00641
constant: false
name: L-glutamine
initial amount: NaN
is: CHEBI:18050

http://identifiers.org/biomodels.db/MODEL1310110004#_600bc67a_91a6_483a_8ec8_3e92c2e09ccb
name: LDHAL6B
is: Q9BYZ2
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:92483

metaM fgam c
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: HMDB01308
is: C04376
is: CHEBI:58426
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
constant: false

metaR r1381
kinetic law: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is: SBO:0000176
fast: false
reactant: MODEL1310110004#
product: MODEL1310110004#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
reversible: true

metaR HEXCOAACBP
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexanoyl-CoA (n-C6:0CoA) from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_082d1a1c_791c_4d3e_bb8a_c1d4afb209c2
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:5145
has only substance units: false
name: PDE6A
is: P16499
type: Species
is: SBO:0000252

metaR r0718
reactant: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110004#
fast: false
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/1.1.1.181
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaM omhpal r
type: Species
boundary condition: false
initial amount: NaN
is: HMDB06294
is: SBO:0000247
name: w-hydroxypalmiticacid
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C16H30O3 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110004#_a87cb456_1ef3_4576_900e_50ee96705448
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:AA676725
name: _AA676725_1_c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_f350f795_9f95_45b9_bbc4_9337d1aa4546
is encoded by: hsa:8867
type: Species
initial concentration: NaN
constant: false
name: SYNJ1
is: SBO:0000252
is: O43426
has only substance units: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_466255c6_48b0_41ab_a2a4_3ae4677a5864
has only substance units: false
name: MTMR1
initial concentration: NaN
is: Q13613
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:8776
type: Species
initial amount: NaN

metaM n2m2nmasn e
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
initial concentration: 1.0
is: C04946
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
initial amount: NaN
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_a8ebe95c_a4d4_4e9c_bb67_b6734c4254c1
boundary condition: true
is: SBO:0000252
name: INPP1
initial amount: NaN
initial concentration: NaN
is: P49441
has only substance units: false
is encoded by: hsa:3628
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_50c196de_08cc_4432_8a9d_a0e9a120c3ef
boundary condition: true
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN
is encoded by: hsa:522
has part: Q6IB54
type: Species
is: SBO:0000297
initial concentration: NaN
constant: false

metaM pmtcoa r
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial concentration: 1.0
is: CHEBI:3454
is: C00154
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: HMDB01338
type: Species

metaM sarcs c
has only substance units: false
name: Sarcosine
is: C00213
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:3513
is: HMDB00271
notes: FORMULA: C3H7NO2 CHARGE: 0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_0d725592_69ad_4bf2_8979_3ac6aa127a52
is: Q9HCR9
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:50940
constant: false
has only substance units: false
name: PDE11A
is: SBO:0000252

metaR HSAT3ly
kinetic law: MODEL1310110004#
fast: false
product: MODEL1310110004#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110004#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
reversible: false

metaM octa c
initial amount: NaN
type: Species
name: octanoate (n-C8:0)
is: SBO:0000247
notes: FORMULA: C8H15O2 CHARGE: -1
is: CHEBI:25646
boundary condition: false
initial concentration: 1.0
constant: false
is: C06423
is: HMDB00482
has only substance units: false

metaM ksii core4 pre2 g
boundary condition: false
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: C00130
is: CHEBI:58053
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00175
initial concentration: 1.0
name: keratan sulfate II boisynthesis, precursor 2
is: SBO:0000247
type: Species

metaR GLYSNAT5tc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR MM7B2g
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.113
reversible: false
is: SBO:0000176
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
reactant: MODEL1310110004#
product: MODEL1310110004#

metaR FAOXC13C11m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C13-->C11)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_47c202b8_135f_4373_ab5b_d5772ea946de
has only substance units: false
initial amount: NaN
boundary condition: true
name: MAN2B1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4125
is: O00754
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_9651a1b7_c669_4e1a_bea1_104c528166bd
name: ST20
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:400410
initial amount: NaN
initial concentration: NaN
is: Q9HBF5
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_d0ce6960_99db_4e6e_b902_f874dac7902c
constant: false
name: CPT1C
has only substance units: false
is: Q8TCG5
type: Species
is encoded by: hsa:126129
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_1cc88cfe_e092_4ef4_bef0_d5e43d515a02
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:314
type: Species
name: AOC2
boundary condition: true
constant: false
has only substance units: false

metaM 2hexdtricoa m
name: 2,7,10-hexadecatrienoylcoa
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247
is: HMDB02288
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_cded700d_f60f_4866_9fe0_53f9588d034f
initial concentration: NaN
constant: false
is encoded by: hsa:219
boundary condition: true
is: P30837
name: ALDH1B1
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_15c13e71_6ea3_48c7_8c06_2347b99608f1
is encoded by: hsa:218
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: ALDH3A1
initial concentration: NaN
is: P30838
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_a5c3a7da_cd2a_45ed_9ddc_085fe0891727
is: F8VQS7
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:55967
boundary condition: true
is: SBO:0000252
constant: false
name: NDUFA12
has only substance units: false

metaR RE3301C
fast: false
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
name: RE3301
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.4
kinetic law: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000000
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_cb57363a_6ca7_42c4_8b4b_d8412bc896ff
is: SBO:0000252
is encoded by: hsa:2348
constant: false
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: FOLR1

metaM mev R c
initial amount: NaN
is: CHEBI:36464
boundary condition: false
constant: false
is: HMDB00227
is: SBO:0000247
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
initial concentration: 1.0
name: (R)-mevalonate
has only substance units: false
type: Species

metaM 5aizc c
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB06273
is: CHEBI:58564
is: C04751
constant: false
boundary condition: false
initial amount: NaN
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
has only substance units: false
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751

metaM o2s e
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB02168
is: CHEBI:18421
name: superoxide
constant: false
has only substance units: false

metaM n2m2nmasn g
constant: false
has only substance units: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
is: C04946
initial concentration: 1.0
initial amount: NaN
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
boundary condition: false
type: Species
is: SBO:0000247

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaM sarcs e
is: CHEBI:15611
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-4-2-3(5)6/h4H,2H2,1H3,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
constant: false
boundary condition: false
name: sarcosine
initial amount: NaN
initial concentration: 1.0
is: HMDB00271
is: SBO:0000247
type: Species
has only substance units: false

metaM doco13ecoa x
initial concentration: 1.0
name: 13-docosenoylcoa
is: http://identifiers.org/pubchem.compound/24892791
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C43H72N7O17P3S CHARGE: -4

metaM ins c
is: CHEBI:17596
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: C00294
boundary condition: false
name: Inosine
is: HMDB00195
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_b66e3a41_3c29_49f4_83af_6a8bd2590818
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: SLC12A7
constant: false
is: Q9Y666
boundary condition: true
is encoded by: hsa:10723
type: Species
has only substance units: false

metaR RBFK
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.26
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: riboflavin kinase
product: MODEL1310110004#
is: SBO:0000176
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110004#
reversible: false
reactant: MODEL1310110004#

metaR RE0935E
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
name: RE0935
reversible: true
fast: false

metaR r2413
type: Reaction
product: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reactant: MODEL1310110004#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
fast: false
kinetic law: MODEL1310110004#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_e64f90c9_1c29_425e_a1a0_f710cee16309
boundary condition: true
is encoded by: hsa:481
initial amount: NaN
name: ATP1B1
type: Species
has only substance units: false
is: A3KLL5
is: SBO:0000252
initial concentration: NaN
constant: false

metaM stcoa c
type: Species
boundary condition: false
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57394
initial amount: NaN
is: C00412
name: Stearoyl-CoA (n-C18:0CoA)
is: HMDB01114
has only substance units: false

metaR B3GALT5g
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: false
name: Beta-1,3-galactosyltransferase 5
fast: false
reactant: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
type: Reaction
is described by: ECO:0000269

metaR ARACHCRNt
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
product: MODEL1310110004#
fast: false
reversible: false
name: transport into the mitochondria (carnitine)
is: SBO:0000185

metaR SARDHm
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
name: Sarcosine dehydrogenase (m)
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.5.99.1
is described by: ECO:0000269

metaR PROSTGE2t
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185
fast: false
name: prostaglandin transport via bicarbonate countertransport
reactant: MODEL1310110004#
type: Reaction
reversible: true
modifier: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110004#_5c6f5eec_3128_4331_abde_260ec610813f
is encoded by: hsa:343
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: AQP8
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: O94778

metaR EX c4crn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for butyryl carnitine
type: Reaction

metaM nadph c
is: CHEBI:57783
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
has only substance units: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: HMDB00221
boundary condition: false
is: C00005

http://identifiers.org/biomodels.db/MODEL1310110004#_51c1c24d_ec40_44e3_83f7_1c9337f1f81c
initial amount: NaN
type: Species
name: MGST3
is: O14880
is encoded by: hsa:4259
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false

metaR HDCAtr
reversible: true
kinetic law: MODEL1310110004#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
name: fatty acid transport via diffusion
product: MODEL1310110004#

metaR GARFT
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
name: phosphoribosylglycinamide formyltransferase
is version of: http://identifiers.org/ec-code/2.1.2.2
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
fast: false

metaR B3GNT39g
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110004#
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
reversible: false
fast: false

metaM HC01602 c
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: C00234
name: 10-Formyltetrahydrofolate
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57454
initial amount: NaN
boundary condition: false

metaM ins e
is: C00294
is: SBO:0000247
is: HMDB00195
type: Species
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
name: Inosine
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:17596
has only substance units: false

metaM hpdcacrn c
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
is: HMDB06210
is: SBO:0000247
name: heptadecanoyl carnitine
type: Species
initial concentration: 1.0
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3

metaR PItn
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: phosphate transport, nuclear
kinetic law: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_110fd217_91bf_41b2_9ed7_9707124d5c41
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2645
has only substance units: false
type: Species
name: GCK

http://identifiers.org/biomodels.db/MODEL1310110004#_a217f43c_db5b_4d28_a33a_c6718f370c25
initial concentration: NaN
name: INPP5A
is encoded by: hsa:3632
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: Q14642

metaM m2gacpail hs r
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:16038
constant: false
type: Species
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_2f3abe88_86c0_4820_a490_4b7f875fa54b
is: SBO:0000252
type: Species
is encoded by: hsa:205
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: P27144
has only substance units: false
name: AK4

metaM nh4 c
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: C01342
name: Ammonium
is: CHEBI:28938
initial concentration: 1.0
is: HMDB00051

metaM pmtcoa x
constant: false
has only substance units: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false
is: C00154
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
is: CHEBI:57379
is: HMDB01338

http://identifiers.org/biomodels.db/MODEL1310110004#_1035d5fd_df48_4f29_9447_e1ccdcc26c4d
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SLC16A2
constant: false
type: Species
boundary condition: true
is encoded by: hsa:6567
is: P36021

http://identifiers.org/biomodels.db/MODEL1310110004#_27a4f3e7_38b2_460b_a11a_7c2231c0b697
has part: B4DY56
is encoded by: hsa:498
type: Species
is: SBO:0000297
initial amount: NaN
initial concentration: NaN
constant: false
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
boundary condition: true
has only substance units: false

metaR C101CPT1
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_269c9391_0ea6_4d3a_9dd4_a0f6928510c0
boundary condition: true
has only substance units: false
is encoded by: hsa:10164
is: Q8NCG5
type: Species
initial amount: NaN
constant: false
name: CHST4
initial concentration: NaN
is: SBO:0000252

metaR r0936
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Transport reaction
product: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false

metaM gly m
name: Glycine
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: C00037
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
constant: false
type: Species
is: HMDB00123
is: CHEBI:15428
boundary condition: false

metaM cbasp e
constant: false
is: C00438
initial amount: NaN
name: N-Carbamoyl-L-aspartate
is: CHEBI:32814
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H6N2O5 CHARGE: -2
is: HMDB00828
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_7c6f4e09_d1c2_499e_9c2f_de5137a55be5
initial concentration: NaN
name: PMVK
type: Species
is encoded by: hsa:10654
constant: false
is: Q6FGV9
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR CYTK6n
modifier: MODEL1310110004#
is: SBO:0000176
name: cytidylate kinase (CMP,CTP),nuclear
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM HC01409 m
has only substance units: false
is: CHEBI:27540
constant: false
name: Hexanoyl-CoA
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR 4NPHSULT
is version of: http://identifiers.org/ec-code/2.8.2.1
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110004#
is: SBO:0000176
name: 4-Nitrophenol Sulfotransferase
reactant: MODEL1310110004#
product: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Cytochrome metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/05)

metaM pa hs c
boundary condition: false
is: SBO:0000247
name: phosphatidate(2-)
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
constant: false
is: CHEBI:57739
type: Species
initial concentration: 1.0

metaM dhcholestanate c
constant: false
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00359
is: CHEBI:16577
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_0f0b6d80_e6a3_430d_af03_8d1dab2ba691
has only substance units: false
name: NME2
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P22392
initial concentration: NaN
type: Species
is encoded by: hsa:4831

http://identifiers.org/biomodels.db/MODEL1310110004#_d2f9a5bd_6831_41ea_a19d_c78d59bd764b
constant: false
type: Species
is: Q7Z7B1
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:284098
name: PIGW
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_0d338a64_8ec7_4615_ae19_7bc37ece6567
is encoded by: hsa:2348
name: FOLR1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
constant: false

metaM lnlccrn m
initial amount: NaN
is: HMDB06469
boundary condition: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
name: Linoleyl carnitine
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species

metaR r1050
is: SBO:0000185
name: Vesicular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10772724,PMID:12856181 NOTES:
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
product: MODEL1310110004#
fast: false
reversible: true

metaR LGTHL
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
fast: false
is: SBO:0000176
modifier: MODEL1310110004#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.4.1.5
name: lactoylglutathione lyase
kinetic law: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
reversible: false

metaM dmnoncrn m
has only substance units: false
name: 4,8 dimethylnonanoyl carnitine
initial amount: NaN
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
initial concentration: 1.0
type: Species
is: HMDB06202
constant: false
is: SBO:0000247
boundary condition: false

metaR r0937
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Transport reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110004#
is: SBO:0000185
reversible: true

metaM HC02213 c
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
is: SBO:0000247
name: prostaglandin-e3
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28031

metaR MI14Ptn
type: Reaction
reversible: true
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
fast: false
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185

metaR FUCASE2e
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.51 Confidence Level: 4 AUTHORS: PMID:10460218,PMID:11389735,PMID:12604617,PMID:2317201 NOTES:NCD
name: alpha-fucosidase, extracellular
is version of: http://identifiers.org/ec-code/3.2.1.51
is described by: ECO:0000000
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000176
modifier: MODEL1310110004#
reversible: false
product: MODEL1310110004#
type: Reaction

metaM nh4 e
initial amount: NaN
type: Species
is: SBO:0000247
name: ammonium
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:28938
initial concentration: 1.0
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaR FAOXC18480m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of fatty acid
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
reactant: MODEL1310110004#
fast: false
reversible: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000

metaM q10 e
type: Species
name: ubiquinone-10
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
initial concentration: 1.0
is: HMDB01072
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:46245

metaM n2m2nmasn l
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
is: C04946
type: Species
notes: FORMULA: C58H96N5O40X CHARGE: 0
boundary condition: false
has only substance units: false
constant: false

metaR GPAM hs
notes: GENE_ASSOCIATION: (57678.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 2.3.1.15 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
name: glycerol-3-phosphate acyltransferase
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.15
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110004#
reactant: MODEL1310110004#

metaM hdcoa m
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: Hexadecenoyl-CoA (n-C16:1CoA)
type: Species
constant: false
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
is: HMDB06532
initial amount: NaN

metaM 3hmbcoa m
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57312
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
initial concentration: 1.0
is: HMDB01356
initial amount: NaN
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
type: Species
boundary condition: false

metaM HC01496 m
boundary condition: false
constant: false
name: 2-Amino-3-oxoadipate
is: CHEBI:28095
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520

http://identifiers.org/biomodels.db/MODEL1310110004#_800341bd_3b0b_458a_9eff_f084a73beb29
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:9583
constant: false
boundary condition: true
is: Q9Y227
is: SBO:0000252
type: Species
name: ENTPD4

http://identifiers.org/biomodels.db/MODEL1310110004#_28562e86_99f3_4b03_a7f2_cfebf3dbfeda
has only substance units: false
initial concentration: NaN
is: Q96M32
initial amount: NaN
name: AK7
constant: false
is: SBO:0000252
is encoded by: hsa:122481
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_b774270d_8f1a_42c0_854d_ea2aaa4fcd8f
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:7991
name: TUSC3

metaR CHOLK
notes: GENE_ASSOCIATION: (1120.2) or (1119.1) or (1120.1) or (1119.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.32
is described by: ECO:0000269
product: MODEL1310110004#
reversible: false
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
name: Choline kinase
reactant: MODEL1310110004#
type: Reaction

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM gly c
initial concentration: 1.0
boundary condition: false
is: CHEBI:3339
name: Glycine
initial amount: NaN
is: SBO:0000247
is: C00037
has only substance units: false
is: HMDB00123
constant: false
type: Species
notes: FORMULA: C2H5NO2 CHARGE: 0

metaM eicostetcoa c
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
has only substance units: false
is: C16164
initial amount: NaN
type: Species
name: eicosatetranoyl coenzyme A
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_b1625d45_af6c_4103_9f53_94945c96360d
initial amount: NaN
is: SBO:0000252
is: P49189
boundary condition: true
constant: false
name: ALDH9A1
has only substance units: false
type: Species
is encoded by: hsa:223
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_e996c0a0_ec8a_46b0_88c0_00e69165a5a5
type: Species
is: SBO:0000252
initial amount: NaN
name: CYP27A1
is encoded by: hsa:1593
constant: false
has only substance units: false
is: Q02318
initial concentration: NaN
boundary condition: true

metaR r0633
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.3
modifier: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
is: SBO:0000176
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
name: trans-Oct-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

metaR AG13T14g
type: Reaction
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110004#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110004#
is: SBO:0000176
fast: false

metaM dec47dicoa m
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false
constant: false
initial amount: NaN
name: 4,7-decadienoylcoa
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_9d4bec52_e43a_4446_baa9_52e3d671f217
has part: Q8TBF5
initial amount: NaN
name: PIGX:PIGM
is: SBO:0000297
is encoded by: hsa:93183
is encoded by: hsa:54965
has only substance units: false
constant: false
type: Species
boundary condition: true
has part: Q9H3S5
initial concentration: NaN

metaM tdcrn e
notes: FORMULA: C21H41NO4 CHARGE: 0
is: HMDB05066
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
name: myristoyl carnitine
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_1144b7c6_7faf_42d5_a66c_5895f8bc63cd
is: SBO:0000252
is encoded by: hsa:2974
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: GUCY1B2

metaM q10 c
name: ubiquinone-10
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:46245
is: HMDB01072

metaM meoh c
initial amount: NaN
initial concentration: 1.0
name: methanol
boundary condition: false
is: SBO:0000247
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
is: HMDB01875
constant: false
type: Species
is: CHEBI:17790
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_f8e2de78_0776_4b21_93fd_40dce4e7c6bd
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:27124
type: Species
initial concentration: NaN
boundary condition: true
is: Q15735
name: INPP5J
constant: false

metaM c6dc c
initial amount: NaN
has only substance units: false
is: HMDB00705
constant: false
notes: FORMULA: C13H22NO6 CHARGE: -1
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
name: adipoyl carnitine

metaR r0634
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.4.1
fast: false
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
is: SBO:0000176

metaM 4hexdtricoa m
boundary condition: false
is: HMDB02288
is: SBO:0000247
type: Species
initial amount: NaN
name: 4,7,10-hexadecatrienoylcoa
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
constant: false
has only substance units: false

metaM 2dr1p c
has only substance units: false
initial concentration: 1.0
name: 2-Deoxy-D-ribose 1-phosphate
is: SBO:0000247
type: Species
is: HMDB01351
initial amount: NaN
boundary condition: false
constant: false
is: C00672
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
is: CHEBI:58576

metaM o2s n
name: superoxide
constant: false
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB02168

metaM h2o2 x
is: C00027
is: HMDB03125
initial concentration: 1.0
is: CHEBI:16240
is: SBO:0000247
name: Hydrogen peroxide
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027

metaM HC02213 e
is: CHEBI:28031
constant: false
initial amount: NaN
initial concentration: 1.0
name: prostaglandin-e3
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
boundary condition: false

metaM alpa hs c
has only substance units: false
initial amount: NaN
is: CHEBI:52288
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H6O5PFULLRCO2 CHARGE: -2 INCHI: InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)
constant: false
type: Species
name: lysophosphatidic acid
initial concentration: 1.0

metaM 5mthf c
is: SBO:0000247
is: HMDB01396
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: C00440
is: CHEBI:3729
type: Species
has only substance units: false
constant: false
boundary condition: false
name: 5-Methyltetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110004#_67477af5_5041_4051_9cef_1b103c4f43c0
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:2678
name: GGT1

metaR SRTNt6 2 r
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (6532.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110004#
name: Seratonin reversible transport in via sodium symport/potassium antiport (1:2)
type: Reaction
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000269
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_6f99e41b_44e2_4a7e_88f1_ddaf19a216dd
constant: false
name: SLC3A1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6519
is: Q07837
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true

metaM hdcoa c
initial amount: NaN
name: Hexadecenoyl-CoA (n-C16:1CoA)
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB06532
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_cde07ca9_675e_4230_9728_f7734bf4e405
is encoded by: hsa:10331
is: Q9Y2A9
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: B3GNT3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_6d6529f3_d94c_4bc2_981b_4dec27172cc4
initial amount: NaN
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: Q5FC00
name: CA6
is: SBO:0000252
has only substance units: false
is encoded by: hsa:765

metaR A MANASEly
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.24
reactant: MODEL1310110004#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
name: alpha-mannosidase, lysosomal
reversible: false
modifier: MODEL1310110004#
product: MODEL1310110004#

metaM sarcs m
name: Sarcosine
is: HMDB00271
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: C00213
has only substance units: false
is: CHEBI:15611
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: SBO:0000247

metaM o2s m
name: Superoxide anion
boundary condition: false
is: C00704
is: CHEBI:18421
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB02168
is: SBO:0000247
type: Species
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704

metaM C05965 e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57444
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: HMDB04243
name: 12(S)-HPETE(1-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_bcbaaa82_e970_4280_9ac5_edfa86f51210
initial concentration: NaN
is encoded by: hsa:AA278423
initial amount: NaN
name: _AA278423_1_c
type: Species
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR 2OXOADOXm
type: Reaction
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.61
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
is described by: ECO:0000304
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
kinetic law: MODEL1310110004#
reversible: false
modifier: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.2.4.2
fast: false

metaM nm4masn g
is: C05882
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C54H90N3O40X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110004#_b65f1f5a_3a22_443a_a171_a048c6970534
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:1962
is: SBO:0000252
is: Q9NY65
name: EHHADH

http://identifiers.org/biomodels.db/MODEL1310110004#_d21d583b_27ff_4534_ad7d_21eaf87d47f1
name: _AA081045_1_c
type: Species
is encoded by: hsa:AA081045
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN

metaM ha l
initial concentration: 1.0
name: hyaluronan
initial amount: NaN
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:16336
type: Species

metaM tdcrn c
has only substance units: false
is: SBO:0000247
is: HMDB05066
initial concentration: 1.0
type: Species
name: myristoyl carnitine
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C21H41NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110004#_db2b53a8_0cd8_4f88_9b46_7690531fb694
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10632
initial amount: NaN
type: Species
is: O75964
constant: false
has only substance units: false
name: ATP5L

metaM xolest2 hs e
type: Species
is: CHEBI:17002
has only substance units: false
initial concentration: 1.0
name: cholesterol ester
initial amount: NaN
boundary condition: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
is: SBO:0000247
constant: false

metaM glu5p m
name: L-Glutamate 5-phosphate
is: HMDB01228
type: Species
is: CHEBI:58274
boundary condition: false
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR RDH3a
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.1.1.105
reversible: true
name: retinol dehydrogenase (11-cis,NADPH)
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.300
reactant: MODEL1310110004#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_e8e9b025_99cc_4f83_a34a_6ed8435748b8
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000297
is encoded by: hsa:480
has part: Q13733
name: ATP1A4:ATP1B1
type: Species
initial concentration: NaN

metaM meoh e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: methanol
boundary condition: false
is: HMDB01875
constant: false
notes: FORMULA: CH4O1 CHARGE: 0 INCHI: InChI=1S/CH4O/c1-2/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00130 EHMN_ABBREVIATION: C00132
is: CHEBI:17790
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_75ac2bc7_dec2_44f3_9b13_9b8d62e30cc0
has only substance units: false
initial concentration: NaN
name: CHKA
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1119
type: Species
initial amount: NaN

metaM acgam r
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
name: N-acetyl-D-glucosamine
is: CHEBI:17411
boundary condition: false
constant: false
is: HMDB00215
is: SBO:0000247

metaR LINKDEG3ly
reactant: MODEL1310110004#
reversible: false
name: degradation of proteoglycan linkage region, lysosomal
kinetic law: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
product: MODEL1310110004#
fast: false
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110004#_49872d66_71b7_4913_af95_a2e5ec535314
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:286297
name: _286297_1_c

metaM 5mthf e
name: 5-Methyltetrahydrofolate
is: HMDB01396
initial amount: NaN
initial concentration: 1.0
is: C00440
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: CHEBI:3729
constant: false
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM 3thexddcoa m
name: 3-hydroxy trans7,10-hexadecadienoylcoa
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
is: SBO:0000247
is: HMDB02014
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_2d9c312e_f037_4355_a824_102a3964901c
is: SBO:0000252
type: Species
is encoded by: hsa:377677
is: Q8N1Q1
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: CA13
constant: false

metaR HSD11B2r
is: SBO:0000176
type: Reaction
product: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.1.1.146
notes: GENE_ASSOCIATION: (3291.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
kinetic law: MODEL1310110004#
reversible: true
is described by: ECO:0000269
fast: false
reactant: MODEL1310110004#
name: 11-beta-hydroxysteroid dehydrogenase type 2

http://identifiers.org/biomodels.db/MODEL1310110004#_6c953a88_e6c5_4eb5_8fa9_d32b15aa879b
has only substance units: false
name: ACO2
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q99798
is encoded by: hsa:50

metaR r0074
modifier: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.1
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
is described by: ECO:0000000
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
reversible: true
kinetic law: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
fast: false
product: MODEL1310110004#

metaM 3hddcoa c
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
is: SBO:0000247
is: HMDB00623
boundary condition: false
initial amount: NaN
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_3df31b9c_1b0e_4fd4_a9ed_6d87751db8d4
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is: A8K0S7
name: SLC37A4
constant: false
is encoded by: hsa:2542

http://identifiers.org/biomodels.db/MODEL1310110004#_3af498e3_fd6a_4899_b193_f5dc19c809ac
is: P08842
name: STS
has only substance units: false
is encoded by: hsa:412
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true

metaR AG13T4g
product: MODEL1310110004#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110004#

metaR ICDHy
is: SBO:0000176
fast: false
reactant: MODEL1310110004#
product: MODEL1310110004#
name: isocitrate dehydrogenase (NADP)
type: Reaction
modifier: MODEL1310110004#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
kinetic law: MODEL1310110004#
is described by: ECO:0000269

metaR PItx
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
reversible: true
name: Phosphate transporter, peroxisome
product: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#

metaR LNELDCt
reactant: MODEL1310110004#
product: MODEL1310110004#
name: fatty acid transport via diffusion
reversible: true
kinetic law: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is described by: ECO:0000000
fast: false

metaM lnlccrn c
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial amount: NaN
is: HMDB06469
name: Linoleyl carnitine
type: Species
constant: false
is: SBO:0000247

metaR S6TASE18ly
reactant: MODEL1310110004#
is: SBO:0000176
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
type: Reaction
fast: false
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.6.14
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000

metaM adp c
is: http://identifiers.org/pubchem.compound/3310
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01341
is: C00008
is: CHEBI:16761
has only substance units: false
name: ADP
is: SBO:0000247
type: Species
boundary condition: false

metaM 3hpp m
type: Species
constant: false
is: HMDB00700
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:16510
initial amount: NaN
initial concentration: 1.0
name: 3-hydroxypropionate

metaR S6TASE5ly
name: N-acetylgalactosamine-6-sulfatase, lysosomal
is: SBO:0000176
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: true
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
product: MODEL1310110004#

metaM HC02216 e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta
is: SBO:0000247
constant: false
is: CHEBI:28922
has only substance units: false
type: Species

metaM itaccoa m
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: itaconyl-CoA(5-)
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
constant: false
initial concentration: 1.0
is: CHEBI:57381
type: Species
boundary condition: false
is: HMDB03377

metaR S6T10g
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110004#
is described by: ECO:0000000
modifier: MODEL1310110004#
reversible: false
fast: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction

metaR CHLtm
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110004#
name: choline transport via diffusion (cytosol to mitochondria)
is: SBO:0000185
product: MODEL1310110004#
reactant: MODEL1310110004#

metaR HDD2COAtx
name: hdd2coa intracellular transport
kinetic law: MODEL1310110004#
is: SBO:0000185
reactant: MODEL1310110004#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
fast: false
product: MODEL1310110004#

metaM prostgi2 c
boundary condition: false
is: SBO:0000247
is: HMDB01335
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
name: prostaglandin I2(1-)
constant: false
is: CHEBI:57403

metaR AKR1C41
modifier: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/1.1.1.225
type: Reaction
reversible: false
kinetic law: MODEL1310110004#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110004#
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)

metaM dmnoncrn c
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB06202
has only substance units: false
type: Species
name: 4,8-dimethylnonanoyl carnitine
notes: FORMULA: C18H37NO4 CHARGE: 0

metaM ha e
name: hyaluronan
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16336
has only substance units: false

metaM nadph m
constant: false
initial amount: NaN
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
has only substance units: false
is: SBO:0000247
is: HMDB00221
boundary condition: false
initial concentration: 1.0
is: C00005
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
type: Species

metaR INSTt4
name: inositol transport via sodium symport
product: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110004#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_8d1aa188_2f13_4b3b_8f71_556d8059a573
is encoded by: hsa:23464
name: GCAT
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is: E2QC23
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_7f6926f7_2c17_43eb_85d6_f8407b47c5b5
is encoded by: hsa:10768
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is: O43865
name: AHCYL1
initial amount: NaN
type: Species

metaM gpi hs r
is: CHEBI:16240
has only substance units: false
boundary condition: false
is: HMDB03125
name: {[PE-Man-],[PE-]Man},{PE-}Man-GlcN-acylPI
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110004#_21e87111_7227_44f1_a3b7_01a752e69e9d
boundary condition: true
is: Q86YI5
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1737
name: DLAT
initial amount: NaN
type: Species
constant: false
has only substance units: false

metaR ATPS4m
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.6.3.14
is version of: http://identifiers.org/ec-code/3.6.4.6
reversible: false
name: ATP synthase (four protons for one ATP)
fast: false
type: Reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (513.1 and 498.2 and 506.1 and 509.2 and 514.1 or 498.2 and 513.2 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 514.2 and 506.1 or 498.2 and 513.2 and 506.1 and 509.2 and 514.1 or 513.2 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 498.1 and 506.1 and 509.2 and 514.1 or 513.1 and 498.2 and 514.2 and 506.1 and 509.2 or 513.1 and 498.2 and 509.1 and 506.1 and 514.1 or 498.2 and 509.1 and 513.2 and 506.1 and 514.1 or 513.2 and 498.1 and 506.1 and 509.2 and 514.1 or 513.2 and 514.2 and 506.1 and 509.2 and 498.3 or 513.2 and 506.1 and 509.2 and 498.3 and 514.1 or 513.1 and 509.1 and 506.1 and 498.3 and 514.1 or 509.1 and 513.2 and 514.2 and 506.1 and 498.3 or 513.1 and 498.2 and 509.1 and 514.2 and 506.1 or 513.1 and 498.1 and 514.2 and 506.1 and 509.2 or 513.1 and 509.1 and 498.1 and 506.1 and 514.1 or 513.1 and 506.1 and 509.2 and 498.3 and 514.1 or 509.1 and 513.2 and 506.1 and 498.3 and 514.1 or 513.1 and 514.2 and 506.1 and 509.2 and 498.3 or 509.1 and 513.2 and 498.1 and 506.1 and 514.1 or 513.1 and 509.1 and 514.2 and 506.1 and 498.3 or 498.2 and 509.1 and 513.2 and 514.2 and 506.1 or 509.1 and 513.2 and 498.1 and 514.2 and 506.1) and (10632.1 and 4905.1 and 10476.1 and 9551.3 and 522.5 and 516.2 and 521.1 and 515.1 or 518.3 and 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 9551.3 and 522.3 or 4905.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 517.2 and 9551.2 and 522.3 or 10632.1 and 4905.1 and 10476.1 and 522.5 and 9551.2 and 518.2 and 521.1 and 515.1 or 4905.1 and 515.2 and 10476.2 and 516.2 and 521.1 and 10632.1 and 9551.3 and 522.5 or 518.3 and 4905.1 and 9551.1 and 515.2 and 10476.2 and 521.1 and 10632.1 and 522.4 or 10632.1 and 4905.1 and 10476.1 and 9551.1 and 522.2 and 515.2 and 518.2 and 521.1 or 518.3 and 10632.1 and 4905.1 and 10476.1 and 515.3 and 9551.2 and 522.4 and 521.1 or 10632.1 and 4905.1 and 10476.1 and 515.3 and 522.2 and 9551.3 and 518.2 and 521.1 or 4905.1 and 9551.1 and 10476.2 and 522…
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.6.1.14
is: SBO:0000185

metaR r0630
is: SBO:0000176
type: Reaction
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.2
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.3.1
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
fast: false

metaR B3GNT311g
reversible: false
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
fast: false
modifier: MODEL1310110004#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is described by: ECO:0000254
is: SBO:0000176

metaM gly e
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:3339
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0
is: C00037
name: Glycine
is: HMDB00123
boundary condition: false
type: Species

metaM hpdcacrn m
name: heptadecanoyl carnitine
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB06210
initial amount: NaN
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_b84b17e4_a0b7_400b_8db9_200b3de0c32c
is: SBO:0000252
constant: false
is: Q96BD0
is encoded by: hsa:28231
initial amount: NaN
boundary condition: true
name: SLCO4A1
has only substance units: false
type: Species
initial concentration: NaN

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM octa e
is: HMDB00482
has only substance units: false
notes: FORMULA: C8H15O2 CHARGE: -1
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:25646
name: octanoate (n-C8:0)
is: C06423
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR RE1534M
name: RE1534
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
fast: false
is described by: ECO:0000000
modifier: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: true
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/4.2.1.17

metaR FAOXC143C123m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaR XOL27OHtm
fast: false
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110004#
name: 27 hydroxy cholesterol transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ

http://identifiers.org/biomodels.db/MODEL1310110004#_2e811d17_2af8_4b6e_b52c_93b5fdf2ce45
name: MAN2A1
initial concentration: NaN
initial amount: NaN
type: Species
is: Q16706
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:4124

metaM omhpal c
notes: FORMULA: C16H30O3 CHARGE: -1
has only substance units: false
initial amount: NaN
is: HMDB06294
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
name: w-hydroxypalmiticacid

http://identifiers.org/biomodels.db/MODEL1310110004#_701e48db_d77f_4e07_aacd_3ab64ede4450
is: O14732
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3613
initial amount: NaN
name: IMPA2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_264cb97d_37ec_4993_aabe_a35887520051
is: P36269
constant: false
initial concentration: NaN
name: GGT5
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:2687
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_f1e2729e_6709_4f52_a960_f8fa7fceb8b3
has only substance units: false
is: P47895
constant: false
initial concentration: NaN
boundary condition: true
name: ALDH1A3
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:220

http://identifiers.org/biomodels.db/MODEL1310110004#_a87aab56_3a0e_492c_8f37_87aca0bc457e
is: SBO:0000252
type: Species
initial amount: NaN
is: O75715
name: GPX5
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2880
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_12a024f1_04a6_4747_85ba_a5c3bb1395f6
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5151
has only substance units: false
constant: false
boundary condition: true
type: Species
name: PDE8A

metaM hs deg13 l
initial amount: NaN
has only substance units: false
is: HMDB01352
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
name: heparan sulfate, degradation product 13
is: CHEBI:17180
constant: false

metaR CYTK2n
reactant: MODEL1310110004#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
name: cytidylate kinase (dCMP),nuclear
product: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM dolp U r
initial amount: NaN
constant: false
initial concentration: 1.0
name: dolichyl phosphate(2-)
type: Species
has only substance units: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
boundary condition: false
is: SBO:0000247
is: CHEBI:57683

metaR VALTA
name: valine transaminase
fast: false
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.6.1.42
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is: SBO:0000176
reactant: MODEL1310110004#
type: Reaction
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110004#

metaM xol7ah c
is: SBO:0000247
is: CHEBI:2290
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
initial amount: NaN
name: 7alpha-hydroxy-5beta-cholestan-3-one
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
has only substance units: false
is: HMDB06892

metaM acgal l
initial amount: NaN
has only substance units: false
is: HMDB00212
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
initial concentration: 1.0
constant: false
type: Species
name: N-acetyl-D-galactosamine
boundary condition: false
is: SBO:0000247
is: CHEBI:28037

metaM inost e
is: CHEBI:17268
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
name: myo-inositol
is: HMDB00211
constant: false
initial amount: NaN

metaR FAOXC4C2m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C4-->C2)m
type: Reaction

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR OBDHc
reversible: false
reactant: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
name: 2-Oxobutanoate dehydrogenase, cytosolic
type: Reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000000

metaR KSII CORE2t
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: keratan sulfate II (core2) transport, golgi to extracellular
reactant: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110004#
reversible: false
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_8fa53417_4358_4ea4_96d0_9cbd32d5c609
constant: false
has only substance units: false
is: Q14435
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:2591
is: SBO:0000252
initial concentration: NaN
name: GALNT3

metaR GCCcm
reversible: true
modifier: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
type: Reaction
reactant: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110004#
name: glycine-cleavage complex (lipoylprotein), mitochondrial
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.10

metaR FAOXC226C225m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

metaR UREAt
reversible: true
type: Reaction
name: Urea transport via facilitate diffusion
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (6523.1) or (6563.1) or (6528.1) or (8170.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:12856182,PMID:2490366,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:JLR

metaR UDPGD
type: Reaction
name: UDPglucose 6-dehydrogenase
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (7358.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 1.1.1.22 Confidence Level: 2 AUTHORS: PMID:9296457,PMID:9737970 NOTES:JLR
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.1.1.22
is: SBO:0000176
product: MODEL1310110004#
reversible: false
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

metaM acgbgbside hs g
type: Species
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
boundary condition: false
initial concentration: 1.0
is: CHEBI:17411
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00215
is: SBO:0000247
name: beta GalNAc globoside

metaM o2 c
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
name: O2
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01377
is: C00007

metaR DNDPt14m
is: SBO:0000185
product: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
reversible: false
name: dUDP transport via dTDP antiport
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110004#_fbc086f8_4544_444b_a4bb_7f9bbca97c1a
initial amount: NaN
name: ACO2
has only substance units: false
initial concentration: NaN
is: Q99798
constant: false
boundary condition: true
is encoded by: hsa:50
type: Species
is: SBO:0000252

metaR r0812
kinetic law: MODEL1310110004#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
product: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000185

metaM ksii core4 deg2 l
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00143
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: keratan sulfate II (core 4-linked), degradation product 2
is: CHEBI:12936
notes: FORMULA: C78H127N6O61S2X CHARGE: -2

metaR RE3566C
reactant: MODEL1310110004#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
type: Reaction
kinetic law: MODEL1310110004#
name: RE3566
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_0ed53e5e_2e10_4cfc_b8d3_f7efec504e00
is encoded by: hsa:52
is: SBO:0000252
has only substance units: false
is: B5MCC7
type: Species
name: ACP1
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false

metaR NTD1
is described by: ECO:0000269
product: MODEL1310110004#
fast: false
reversible: false
name: 5'-nucleotidase (dUMP)
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is: SBO:0000176
modifier: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_8c71d64e_4834_407d_b462_dace5b096c45
type: Species
name: PLCB1
constant: false
initial concentration: NaN
is encoded by: hsa:23236
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true

metaR GGH 7THFl
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (7THF), lysosomal
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#

metaR r1156
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110004#
fast: false
reversible: true
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_9e982b4d_eeb5_4c52_bd23_1981b6baca59
initial amount: NaN
is: SBO:0000252
is: B4E097
name: GALT
type: Species
is encoded by: hsa:2592
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

metaM inost c
constant: false
initial concentration: 1.0
is: CHEBI:17268
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
name: myo-inositol
is: SBO:0000247
is: HMDB00211

http://identifiers.org/biomodels.db/MODEL1310110004#_eaffeba2_7fb3_4575_9942_97a525ff0c17
name: SLC25A4
type: Species
initial amount: NaN
is: P12235
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:291
is: SBO:0000252

metaM core2 g
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C22H37N2O15X CHARGE: 0
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:15876
name: Core 2

metaR FAOXC183C163Gm
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaR O2Stx
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110004#
fast: false
name: superoxide anion transport via diffusion (peroxisome)
reversible: true
product: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_8652d086_7956_42aa_98cb_18b1901daa3c
is: O75489
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4722
type: Species
name: NDUFS3

metaR r0813
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
kinetic law: MODEL1310110004#
reversible: false
product: MODEL1310110004#
is described by: ECO:0000000
modifier: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
fast: false

metaM fn2m2masn g
has only substance units: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
initial amount: NaN
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
is: CHEBI:32984
boundary condition: false

metaM hpyr c
is: HMDB01352
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:17180
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168
has only substance units: false
constant: false
name: 3-hydroxypyruvate

metaR MANtly
reversible: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
fast: false
kinetic law: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110004#
name: mannose efflux from lysosome
is: SBO:0000185

metaR NRVNCCOAtx
reactant: MODEL1310110004#
name: fatty acid intracellular transport
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

http://identifiers.org/biomodels.db/MODEL1310110004#_077e0a5b_db81_4f5a_a90c_0ce9806d174a
is: F8WDN9
is: SBO:0000252
is encoded by: hsa:27068
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
type: Species
initial amount: NaN
name: PPA2

metaM 4ppan c
initial amount: NaN
initial concentration: 1.0
is: HMDB01016
constant: false
name: D-4'-Phosphopantothenate
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
is: CHEBI:10986
is: C03492
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_6cf5497a_fa45_4a7c_a3c5_d7b9348d1916
is encoded by: hsa:211
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: P13196
name: ALAS1
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_ae5c54f4_d260_4d38_b793_0180969e8db2
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: O14939
is: SBO:0000252
is encoded by: hsa:5338
name: PLD2
constant: false

metaR PROt4 2 r
reactant: MODEL1310110004#
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
product: MODEL1310110004#
modifier: MODEL1310110004#
reversible: true
fast: false
name: Proline transport (sodium symport) (2:1)
kinetic law: MODEL1310110004#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_9ba22f16_e3d4_4fde_affc_446051e67eaf
is: Q9Y2B2
constant: false
boundary condition: true
is encoded by: hsa:9487
name: PIGL
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species

metaR S3TASE1ly
reactant: MODEL1310110004#
reversible: true
type: Reaction
product: MODEL1310110004#
kinetic law: MODEL1310110004#
name: N-acetylglucosamine-3-sulfatase, lysosomal
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD

metaR RE1526M
kinetic law: MODEL1310110004#
fast: false
reversible: true
reactant: MODEL1310110004#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
modifier: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is: SBO:0000176
name: RE1526
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR BILGLCURtr
kinetic law: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
reactant: MODEL1310110004#
reversible: true
name: glucuronidated compound transport
fast: false

metaM dutp n
type: Species
is: SBO:0000247
is: CHEBI:17625
is: HMDB01191
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: dUTP

http://identifiers.org/biomodels.db/MODEL1310110004#_19cf3a59_3b8e_4167_ace2_f7b40bdb6e8b
type: Species
has only substance units: false
name: ALDH1B1
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: P30837
is: SBO:0000252
is encoded by: hsa:219

http://identifiers.org/biomodels.db/MODEL1310110004#_44d79431_e5e1_4a34_8df7_f06770dbdfde
name: _AI926493_1_m
constant: false
is encoded by: hsa:AI926493
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR HOCTDECCRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyoctadecanoyl carnitine into extra cellular space
type: Reaction

metaM HC01522 c
is: CHEBI:28508
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
name: Gentisate aldehyde
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
type: Species

metaR C204CPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
name: arachidonic acid transport into the mitochondria
reversible: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
type: Reaction
kinetic law: MODEL1310110004#
fast: false
modifier: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_bb69761b_949f_486e_82d5_b8d62ccc4641
is: P15291
initial amount: NaN
constant: false
name: B4GALT1
has only substance units: false
type: Species
is encoded by: hsa:2683
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR EX tymsf LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyramine O-sulfate exchange
type: Reaction

metaM 2octpencoa m
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247
boundary condition: false
constant: false
type: Species
has only substance units: false
name: 2,6,9,12,15-octadecapentenoylcoa
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C39H56N7O17P3S CHARGE: -4

metaM hdd2coa c
name: trans-Hexadec-2-enoyl-CoA
initial concentration: 1.0
type: Species
is: C05272
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: CHEBI:61526
is: SBO:0000247
is: HMDB03945
constant: false

metaM dopasf e
name: dopamine 3-O-sulfate
type: Species
has only substance units: false
constant: false
is: CHEBI:37946
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
initial concentration: 1.0
initial amount: NaN
is: HMDB06275

metaR RE2814R
product: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
type: Reaction
name: RE2814
reactant: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:

metaM fe2 e
name: Fe2+
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00692
is: SBO:0000247
constant: false
is: CHEBI:29033
initial concentration: 1.0
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
type: Species
is: C00023

http://identifiers.org/biomodels.db/MODEL1310110004#_881db148_cd5d_4788_80a2_0cf09419d29c
is: SBO:0000252
boundary condition: true
is encoded by: hsa:R14373
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
name: _R14373_1_x
type: Species

metaM acgbgbside hs c
initial concentration: 1.0
is: HMDB00215
name: beta GalNAc globoside
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
has only substance units: false
initial amount: NaN
is: CHEBI:17411
type: Species

metaM udpacgal g
boundary condition: false
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: HMDB00304
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:57847

metaR DUDPtn
product: MODEL1310110004#
reactant: MODEL1310110004#
name: dUDP nuclear transport
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_e3ffd9c5_d199_4d8a_8812_f279c28a69e6
has only substance units: false
type: Species
boundary condition: true
name: SGPL1
constant: false
is encoded by: hsa:8879
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: O95470

metaM hdca c
constant: false
name: palmitate
is: CHEBI:7896
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00220
has only substance units: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

metaR r1905
is described by: ECO:0000000
fast: false
reactant: MODEL1310110004#
product: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000185
reversible: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM tsul e
has only substance units: false
is: CHEBI:16094
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
type: Species
boundary condition: false
is: HMDB00257
name: thiosulfate(2-)

http://identifiers.org/biomodels.db/MODEL1310110004#_bf63b979_6865_4b2d_8bf2_f1f1ab6a84b1
constant: false
boundary condition: true
type: Species
is encoded by: hsa:56953
has only substance units: false
is: SBO:0000252
name: NT5M
initial concentration: NaN
initial amount: NaN
is: Q9NPB1

http://identifiers.org/biomodels.db/MODEL1310110004#_7c7864a8_0094_434b_bfe8_723531b9eb64
is: D9HTE9
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:6576
initial concentration: NaN
type: Species
name: SLC25A1
has only substance units: false
constant: false

metaM ksi pre9 g
type: Species
is: C00130
initial amount: NaN
is: CHEBI:58053
boundary condition: false
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 9
constant: false
is: HMDB00175

metaR LTC4CP
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110004#
is: SBO:0000176
reversible: true
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
name: Leukotriene C4 carboxypeptidase
kinetic law: MODEL1310110004#

metaR RE3004M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
kinetic law: MODEL1310110004#
fast: false
name: RE3004
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
product: MODEL1310110004#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_a99c9a0c_06fa_4bf0_96c0_09f5b60ad299
initial amount: NaN
has only substance units: false
is encoded by: hsa:5289
is: SBO:0000252
is: Q8NEB9
name: PIK3C3
initial concentration: NaN
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_cd3b21b5_5d96_490c_bc34_ad8b91aa06a3
is: P04062
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: GBA
is: SBO:0000252
is encoded by: hsa:2629
constant: false
initial amount: NaN

metaR DOPASFt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of dopamine sulfate
fast: false
is: SBO:0000185
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
reversible: false
is described by: ECO:0000000
name: Dopamine 3-0-sulfate transport (diffusion)

metaM chol n
has only substance units: false
initial concentration: 1.0
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
name: choline
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00097
type: Species

metaM dopasf c
boundary condition: false
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
name: dopamine 3-O-sulfate
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB06275
is: CHEBI:37946

metaR FAOXC122m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaR FUMSO3tm
type: Reaction
modifier: MODEL1310110004#
product: MODEL1310110004#
fast: false
reversible: true
is described by: ECO:0000269
is: SBO:0000185
name: Fumarate:sulfite antiport, mitochondrial
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaM pmtcrn x
name: L-palmitoylcarnitine
constant: false
is: HMDB00222
is: SBO:0000247
type: Species
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: CHEBI:17490
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_edd69aa1_253a_48c6_968d_01ed096ba434
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:3418
name: IDH2
initial amount: NaN
is: P48735
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR UDPG4E
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
name: UDPglucose 4-epimerase
reversible: true
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/5.1.3.2
type: Reaction
modifier: MODEL1310110004#
is: SBO:0000176

metaM prpp c
has only substance units: false
initial concentration: 1.0
is: C00119
type: Species
is: CHEBI:58017
boundary condition: false
constant: false
is: SBO:0000247
name: 5-Phospho-alpha-D-ribose 1-diphosphate
initial amount: NaN
is: HMDB00280
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119

metaM mi1p D c
constant: false
type: Species
has only substance units: false
name: 1D-myo-inositol 1-phosphate(2-)
is: HMDB02985
boundary condition: false
is: CHEBI:58433
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_702d9ffa_d076_4ab7_9b8d_4bae968dbd98
constant: false
is encoded by: hsa:3420
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: IDH3B
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_257127e1_8d82_455a_a2a8_688d1b662a64
is encoded by: hsa:80025
initial amount: NaN
name: PANK2
is: SBO:0000252
is: Q6P1K9
type: Species
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR RE2954C
product: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.40
name: RE2954
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
is: SBO:0000176

metaM decdicoa c
name: decadienoylcoa
boundary condition: false
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false
type: Species
is: HMDB01168
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM chol m
initial amount: NaN
type: Species
has only substance units: false
name: choline
boundary condition: false
constant: false
is: SBO:0000247
is: CHEBI:15354
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0
is: HMDB00097

metaM tsul c
is: HMDB00257
constant: false
name: thiosulfate(2-)
boundary condition: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
is: SBO:0000247
is: CHEBI:16094
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_46421873_fd5f_4f5c_9079_6b7fe252a573
is: SBO:0000252
boundary condition: true
is: E7ET32
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
name: GALT
is encoded by: hsa:2592
has only substance units: false

metaM hdca e
is: SBO:0000247
constant: false
initial amount: NaN
is: C00249
is: CHEBI:0
has only substance units: false
is: HMDB00220
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1
initial concentration: 1.0
name: Hexadecanoate (n-C16:0)
boundary condition: false

metaR 4ABUTtcn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
name: transport of GABA
is described by: ECO:0000134
reversible: false
fast: false
kinetic law: MODEL1310110004#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#

metaM betald c
has only substance units: false
is: CHEBI:15710
name: betaine aldehyde
boundary condition: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01252
initial amount: NaN

metaR DURIK1
modifier: MODEL1310110004#
product: MODEL1310110004#
name: deoxyuridine kinase (ATP:Deoxyuridine)
is version of: http://identifiers.org/ec-code/2.7.1.21
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110004#
is described by: ECO:0000254
fast: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:

metaM dd2coa c
boundary condition: false
is: HMDB03712
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: trans-Dodec-2-enoyl-CoA
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
is: SBO:0000247

metaM hxcoa m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
boundary condition: false
type: Species
constant: false
name: Hexanoyl-CoA (n-C6:0CoA)
is: HMDB06522
is: SBO:0000247

metaM udpacgal c
name: UDP-N-acetyl-D-galactosamine(2-)
is: HMDB00304
is: CHEBI:57847
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
initial amount: NaN

metaR HS2ly
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reversible: false
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.10.1.1
fast: false
name: heparan-N-sulfatase, lysosomal
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaR KYNATESYN
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
type: Reaction
reactant: MODEL1310110004#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
kinetic law: MODEL1310110004#
reversible: false
product: MODEL1310110004#
is described by: ECO:0000000

metaR NP1
name: nucleotide phosphatase
is described by: ECO:0000304
product: MODEL1310110004#
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
reactant: MODEL1310110004#

metaM c10dc c
notes: FORMULA: C17H30NO6 CHARGE: -1
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00651
type: Species
initial amount: NaN
name: sebacoyl carnitine
initial concentration: 1.0
has only substance units: false

metaR r0208
product: MODEL1310110004#
type: Reaction
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
is version of: http://identifiers.org/ec-code/4.4.1.1
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#

metaM HC02202 e
initial concentration: 1.0
has only substance units: false
is: CHEBI:57398
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial amount: NaN
constant: false
boundary condition: false
type: Species
name: prostaglandin A1(1-)
is: SBO:0000247

metaR r1757
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110004#
fast: false
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110004#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_02209da6_ce0d_466c_a6b1_e14e8fc8cee2
is: P55084
name: HADHB
boundary condition: true
is encoded by: hsa:3032
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN

metaR r1901
type: Reaction
modifier: MODEL1310110004#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110004#
product: MODEL1310110004#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_f544fa79_a0b6_427d_9bee_33842c97f7ca
constant: false
is: Q15181
initial concentration: NaN
initial amount: NaN
name: PPA1
is encoded by: hsa:5464
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species

metaR THRGLYexR
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true
product: MODEL1310110004#
name: L-threonine/glycine reversible exchange

metaM retn c
type: Species
initial amount: NaN
is: HMDB01852
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
is: CHEBI:35291
boundary condition: false
has only substance units: false
name: all-trans-retinoate
initial concentration: 1.0
is: SBO:0000247

metaR EX hexc LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexacosanoate (n-C26:0) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_9c1161cf_0d5b_4103_b6be_4a2332ca0c74
type: Species
is encoded by: hsa:27010
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: TPK1
has only substance units: false
initial concentration: NaN
is: F5GZG6

metaR r2321
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
product: MODEL1310110004#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction

metaR r0819
modifier: MODEL1310110004#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110004#
is described by: ECO:0000000
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110004#

metaR LACZe
reversible: false
fast: false
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.108
modifier: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
name: b-galactosidase, extracellular
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase

metaR r2535
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
fast: false
product: MODEL1310110004#

metaR GULN3D
kinetic law: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
reversible: true
name: L-gulonate 3-dehydrogenase
is: SBO:0000176

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_4d122178_34ea_4903_9108_18458e4fcc69
is encoded by: hsa:2936
is: SBO:0000252
is: P00390
constant: false
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: GSR

metaR O2Stn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
name: superoxide anion transport via diffusion (nucleus)
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_fc8f445a_2a51_410a_babb_e4e0501eedbb
has part: Q13956
name: PDE6A:PDE6H:PDE6B
constant: false
is: SBO:0000297
boundary condition: true
has part: P16499
type: Species
has part: B7Z9T9
initial amount: NaN
is encoded by: hsa:5149
is encoded by: hsa:5158
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5145

metaM prpp e
is: HMDB00280
initial amount: NaN
constant: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:58017
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119

http://identifiers.org/biomodels.db/MODEL1310110004#_b25819b7_2492_470a_840f_7979fa52ad72
boundary condition: true
type: Species
has only substance units: false
name: NDUFB9
initial concentration: NaN
is encoded by: hsa:4715
initial amount: NaN
is: SBO:0000252
is: Q9Y6M9
constant: false

metaR RE1807C
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
name: RE1807
type: Reaction
fast: false
is: SBO:0000176

metaM gthox c
is: HMDB03337
is: C00127
name: Oxidized glutathione
constant: false
is: CHEBI:58297
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: SBO:0000247

metaR NDPK5n
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110004#
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
type: Reaction
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: true
is: SBO:0000176
product: MODEL1310110004#

metaM HC02202 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: prostaglandin A1(1-)
type: Species
is: CHEBI:57398
boundary condition: false
initial concentration: 1.0

metaR NAIt
fast: false
reactant: MODEL1310110004#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
name: Na+ / iodide cotransport

http://identifiers.org/biomodels.db/MODEL1310110004#_6ee49636_8086_46b6_8687_a88daef3ae32
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:728637
name: _728637_1_c
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_2b054b1b_3fab_4e47_93d0_93c23b83fecb
is encoded by: hsa:112
has only substance units: false
name: ADCY6
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species

metaR r2534
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
product: MODEL1310110004#
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

metaR r2320
fast: false
type: Reaction
product: MODEL1310110004#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110004#_2c2630e4_9a12_41de_91e5_fd3ffcdb8610
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
name: ATP5D
is encoded by: hsa:513
is: SBO:0000252
constant: false
boundary condition: true

metaR RE2814M
name: RE2814
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110004#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
product: MODEL1310110004#
reactant: MODEL1310110004#

metaR O2Stm
is: SBO:0000185
product: MODEL1310110004#
fast: false
reversible: true
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
name: superoxide anion transport via diffusion (mitochondria)
type: Reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000000

metaR r0202
fast: false
product: MODEL1310110004#
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
reversible: true
reactant: MODEL1310110004#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_65b1b606_a95b_4fb7_bc6b_f26060d8ad4b
is encoded by: hsa:6309
constant: false
boundary condition: true
name: SC5DL
initial amount: NaN
is: Q6GTM5
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252

metaR ACNAMlt
reversible: true
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
reactant: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185
fast: false
modifier: MODEL1310110004#
name: N-acetylneuraminate transport into lysososme
is described by: ECO:0000269

metaR HDECAACBP
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecanoylcoa from mitochondria into the cytosol
type: Reaction

metaR r1903
is described by: ECO:0000000
modifier: MODEL1310110004#
fast: false
reversible: false
kinetic law: MODEL1310110004#
is: SBO:0000185
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
product: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_578da907_f202_487e_ae3c_cdb3ff1b1836
is: Q38G75
is: SBO:0000252
name: GALE
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:2582
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_39753733_440d_4371_a9d0_959e8ce89355
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: O76062
boundary condition: true
name: TM7SF2
constant: false
is: SBO:0000252
is encoded by: hsa:7108

metaR FAOXC201C181x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

metaM retn e
constant: false
is: CHEBI:35291
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false
is: SBO:0000247
has only substance units: false
name: all-trans-retinoate
initial concentration: 1.0
initial amount: NaN
is: HMDB01852
type: Species

metaM uacgam c
is: HMDB00290
constant: false
is: CHEBI:57705
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
type: Species
is: SBO:0000247
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_6fa9c571_fc8e_4a17_8e31_a5d29446c209
boundary condition: true
is: Q9BXS1
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:91734
name: IDI2
type: Species

metaM prpncoa m
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: HMDB02307
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57367
name: acryloyl-CoA(4-)

metaM HC01231 m
initial concentration: 1.0
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate
is: CHEBI:58480
boundary condition: false
constant: false
type: Species
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: SBO:0000247
has only substance units: false

metaM fe2 c
is: C00023
is: HMDB00692
is: CHEBI:29033
name: Fe2+
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: Fe CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC01846 EHMN_ABBREVIATION: C00023
has only substance units: false

metaR r1600
type: Reaction
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
product: MODEL1310110004#

metaR MAN6PI
is: SBO:0000176
fast: false
name: mannose-6-phosphate isomerase
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.1.8
is described by: ECO:0000304
modifier: MODEL1310110004#

metaM hxan c
boundary condition: false
has only substance units: false
is: CHEBI:17368
constant: false
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
initial amount: NaN
name: Hypoxanthine
is: HMDB00157
is: SBO:0000247
is: C00262
type: Species
initial concentration: 1.0

metaM gdp g
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
initial concentration: 1.0
is: CHEBI:58189
is: HMDB01201
type: Species
name: GDP(3-)
is: SBO:0000247
boundary condition: false
has only substance units: false
initial amount: NaN

metaM gthox e
is: HMDB03337
type: Species
is: SBO:0000247
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:58297

metaR B3GNT31g
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
kinetic law: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reactant: MODEL1310110004#
is: SBO:0000176
reversible: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110004#_f5bbdda8_11d5_4ca2_b41f_85684f76f791
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: Q92781
name: RDH5
is encoded by: hsa:5959
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_e88ce497_ba58_409f_bbf3_22aeaa9b05ed
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: _NOS2A_1_c
is encoded by: hsa:NOS2A

metaR OCTDECCACT
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_fad55486_1ae4_4e03_908c_367e410b3f4b
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AA177072
is: SBO:0000252
boundary condition: true
name: _AA177072_1_x

metaR RE2799C
is: SBO:0000176
product: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
reactant: MODEL1310110004#
fast: false
name: RE2799
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_16be965e_8f8a_4f79_80d7_4c0909ed6f0a
is: Q9UBF8
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:5298
has only substance units: false
type: Species
name: PI4KB
is: SBO:0000252
initial amount: NaN

metaR FAOXC2452256x
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
modifier: MODEL1310110004#
name: Beta oxidation of long chain fatty acid
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110004#_3d362f24_9bac_4834_a13b_eba0ead6b78b
is: Q08828
is encoded by: hsa:107
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ADCY1
has only substance units: false
constant: false
is: SBO:0000252
type: Species

metaR r2532
product: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110004#
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
kinetic law: MODEL1310110004#
fast: false

metaM tetde5coa x
name: 5-tetradecenoylcoa
is: HMDB13109
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN

metaR GLYSARCNc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Hydrolysis of glycylsarcosine for uptake
type: Reaction

metaM succ x
initial concentration: 1.0
has only substance units: false
is: C00042
name: Succinate
initial amount: NaN
boundary condition: false
type: Species
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: SBO:0000247
is: CHEBI:30031
is: HMDB00254

metaM acgal g
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
constant: false
is: CHEBI:28037
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00212
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: N-acetyl-D-galactosamine

http://identifiers.org/biomodels.db/MODEL1310110004#_5ebf7a81_6b37_47c5_903c_bcb6c36209f1
constant: false
name: _HG2846_HT2983_1_m
initial amount: NaN
boundary condition: true
is encoded by: hsa:HG2846-HT2983
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_888b9702_5ef8_4120_913e_50e51cee9630
has only substance units: false
is encoded by: hsa:5152
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
name: PDE9A

metaR r1602
is: SBO:0000185
reversible: true
product: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110004#

metaR DNDPt29m
kinetic law: MODEL1310110004#
reversible: false
is: SBO:0000185
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000269
name: dCDP transport via dADP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false

metaR MI1345PP
fast: false
reversible: false
product: MODEL1310110004#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.86
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.56
type: Reaction
reactant: MODEL1310110004#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.3.36

metaR r2539
reactant: MODEL1310110004#
type: Reaction
is: SBO:0000185
product: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
name: Postulated transport reaction
kinetic law: MODEL1310110004#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_5de053fc_97b8_4ee0_ab80_e7326a80cda2
name: _728226_1_e
type: Species
is encoded by: hsa:728226
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN

metaR r0960
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
is described by: ECO:0000000
reversible: true
product: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_a3af3f89_4587_4bf2_8379_675fa0849572
boundary condition: true
name: SPTLC2
is: O15270
is: SBO:0000252
type: Species
is encoded by: hsa:9517
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM gdp e
is: SBO:0000247
type: Species
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
boundary condition: false
constant: false
name: GDP(3-)
has only substance units: false
is: CHEBI:58189
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_363590d5_0373_4df2_b416_72afaf4fbd83
type: Species
initial amount: NaN
constant: false
is: E9PAY8
is encoded by: hsa:8612
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: PPAP2C

metaM tsul m
initial amount: NaN
is: HMDB00257
type: Species
initial concentration: 1.0
is: CHEBI:16094
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: thiosulfate(2-)

metaM hxan e
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
has only substance units: false
boundary condition: false
type: Species
is: HMDB00157
is: SBO:0000247
is: CHEBI:17368
name: hypoxanthine

http://identifiers.org/biomodels.db/MODEL1310110004#_e03ff474_e1dd_49c4_ad1b_81b2642caaa4
name: _BF195998_1_x
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:BF195998
constant: false

metaR r2325
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110004#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
product: MODEL1310110004#
reversible: true
is: SBO:0000185
reactant: MODEL1310110004#

metaM dutp m
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:17625
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: dUTP
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: HMDB01191

http://identifiers.org/biomodels.db/MODEL1310110004#_ab4e8e6a_92a4_41f4_9ce4_7cfe84c23e48
initial concentration: NaN
is: SBO:0000252
name: AOC3
type: Species
has only substance units: false
initial amount: NaN
is: Q16853
boundary condition: true
is encoded by: hsa:8639
constant: false

metaR Htg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110004#
product: MODEL1310110004#
fast: false
type: Reaction
reactant: MODEL1310110004#
reversible: true
name: proton diffusion (Golgi)
is described by: ECO:0000000
is: SBO:0000185

metaM 3dodtricoa x
initial concentration: 1.0
is: HMDB11123
constant: false
is: SBO:0000247
is: C05279
initial amount: NaN
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
boundary condition: false
type: Species
name: 3,6,9-dodecatrienoylcoa
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_ce604f7a_dad6_4013_acee_e2d599dc46d2
name: DPM1
is encoded by: hsa:8813
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: O60762
type: Species

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

metaR DESAT16 2
reversible: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
fast: false
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.14.19.1
kinetic law: MODEL1310110004#
name: palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)

http://identifiers.org/biomodels.db/MODEL1310110004#_6dd381e4_f6d1_4e14_bb5a_185911bfd61b
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350
boundary condition: true
initial concentration: NaN
type: Species
has part: O95497
is encoded by: hsa:8876
has only substance units: false
is: SBO:0000297
has part: A8K7W0
is encoded by: hsa:8875
initial amount: NaN
constant: false

metaM dtdp c
has only substance units: false
type: Species
is: SBO:0000247
name: dTDP
is: C00363
is: CHEBI:58369
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_fucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:16094
is: HMDB00257
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
type: Species
constant: false
has only substance units: false
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
initial concentration: 1.0

metaM 5aop m
is: CHEBI:17549
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01149
boundary condition: false
is: C00430
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
initial amount: NaN
name: 5-Amino-4-oxopentanoate
has only substance units: false

metaR r2324
reversible: true
kinetic law: MODEL1310110004#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
product: MODEL1310110004#
is: SBO:0000185
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_c3e46ac8_43a6_4916_93ec_c7d2fa3b63e9
type: Species
constant: false
initial amount: NaN
is: P21589
name: NT5E
is encoded by: hsa:4907
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR r1604
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
fast: false
product: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110004#_066f5caf_0831_4ded_b585_474f79a47743
initial amount: NaN
constant: false
is: SBO:0000252
is: P18405
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6715
boundary condition: true
name: SRD5A1
type: Species

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaR FAOXC241C221x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C24:1-->C22:1)x
type: Reaction

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

metaR FAOXC122x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

metaR LSTO1r
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
is version of: http://identifiers.org/ec-code/1.14.21.6
modifier: MODEL1310110004#
reversible: false
kinetic law: MODEL1310110004#
name: Lathosterol oxidase
fast: false
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110004#

metaR r0817
reactant: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
type: Reaction

metaM gdp c
initial amount: NaN
is: SBO:0000247
type: Species
name: GDP
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
is: C00035
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:58189
constant: false

metaR CYTDt
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
fast: false
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
name: cytidine facilated transport in cytosol
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110004#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110004#_9cea25be_45a0_456d_8cd2_01343b5125e8
initial concentration: NaN
has only substance units: false
name: PANK2
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:80025
constant: false
is: Q9BZ23

http://identifiers.org/biomodels.db/MODEL1310110004#_6ebeb765_cdbb_4924_a826_8b7ae4e38b72
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: Q63HM1
name: AFMID
is encoded by: hsa:125061

metaM uacgam g
constant: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: SBO:0000247
initial concentration: 1.0
is: HMDB00290
has only substance units: false
boundary condition: false
is: CHEBI:57705
initial amount: NaN
type: Species
name: UDP-N-acetyl-alpha-D-glucosamine(2-)

http://identifiers.org/biomodels.db/MODEL1310110004#_b870b495_623d_4203_baa1_735676a1f3be
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:2592
initial concentration: NaN
type: Species
boundary condition: true
is: B2RAT6
name: GALT
has only substance units: false

metaR GALtly
product: MODEL1310110004#
type: Reaction
name: galactose efflux from lysosome
kinetic law: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000

metaR S6T16g
reversible: false
modifier: MODEL1310110004#
is described by: ECO:0000000
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_caec4a38_e3a1_4876_af7f_ac3f2315bc65
name: UCK2
type: Species
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q9BZX2
is encoded by: hsa:7371
initial concentration: NaN
initial amount: NaN

metaR r2323
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reactant: MODEL1310110004#
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction

metaM 7dhchsterol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
is: HMDB00032
type: Species
name: cholesta-5,7-dien-3beta-ol
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17759
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_ad297054_45c0_48de_a347_ed04a5f1c768
name: ENPP1
is: P22413
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:5167
initial amount: NaN
boundary condition: true

metaR r1603
reactant: MODEL1310110004#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110004#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_d26b1c02_57ac_4189_afea_a84c1b57ff32
name: GRHPR
constant: false
boundary condition: true
is: Q9UBQ7
is encoded by: hsa:9380
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false

metaM acgal c
is: HMDB00212
type: Species
initial concentration: 1.0
is: CHEBI:28037
name: N-acetyl-D-galactosamine
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132

metaM m5mpdol U r
initial amount: NaN
has only substance units: false
is: CHEBI:37634
initial concentration: 1.0
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
constant: false

metaM dtdp e
type: Species
is: SBO:0000247
is: CHEBI:58369
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: HMDB01274
initial concentration: 1.0
constant: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
boundary condition: false

metaR FAOXC12DCc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_fc5719cb_5a31_4b87_908e_63fd49c86088
is encoded by: hsa:2983
has part: Q02153
initial concentration: NaN
type: Species
is: SBO:0000297
name: GUCY1A2:GUCY1B3
has only substance units: false
has part: P33402
constant: false
is encoded by: hsa:2977
initial amount: NaN
boundary condition: true

metaR RE1303C
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7937829 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: RE1303
fast: false

metaR r2322
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110004#
product: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r0818
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
reactant: MODEL1310110004#
product: MODEL1310110004#
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110004#
reversible: false

metaR r0531
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.34
reversible: true
modifier: MODEL1310110004#
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
is: SBO:0000176
reactant: MODEL1310110004#
is described by: ECO:0000000

metaR r0644
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#

metaR r2316
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
product: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM Asn X Ser Thr r
type: Species
constant: false
is: CHEBI:28938
has only substance units: false
is: SBO:0000247
boundary condition: false
name: protein-linked asparagine residue (N-glycosylation site)
is: HMDB00051
notes: FORMULA: XH CHARGE: 0
is: C01342
initial amount: NaN
initial concentration: 1.0

metaM ksii core4 pre3 g
has only substance units: false
is: CHEBI:58053
is: C00130
is: HMDB00175
constant: false
boundary condition: false
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 3
type: Species
notes: FORMULA: C55H89N5O38X CHARGE: -1
initial concentration: 1.0
initial amount: NaN

metaR sink dd2coa LPAREN c RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: DD2COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_da78bef9_9b2c_45c3_9dab_2a89e06dfd53
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:10678
name: B3GNT2
constant: false

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaM n2m2mn l
notes: FORMULA: C42H71N3O31 CHARGE: 0
type: Species
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00742
constant: false
is: CHEBI:17588

metaR r1605
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
reactant: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
reversible: true

metaR MTHFR3
fast: false
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.5.1.20
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110004#
is described by: ECO:0000134
reactant: MODEL1310110004#
name: 5,10-methylenetetrahydrofolatereductase (NADPH)
notes: GENE_ASSOCIATION: (4524.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.20 Confidence Level: 2 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 350. NOTES:absorbed folate undergoes conversion to 5-methyl-THF within the enterocytes.

metaR GLYCLTtp
type: Reaction
name: glycolate transport into peroxisome
kinetic law: MODEL1310110004#
reversible: false
product: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
fast: false
reactant: MODEL1310110004#

metaR r0643
fast: false
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#
is described by: ECO:0000000

metaM ksii core4 l
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate II (core 4-linked)
boundary condition: false
type: Species
is: CHEBI:57255
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01014

metaR ADA
is version of: http://identifiers.org/ec-code/3.5.4.4
name: Adenosine deaminase
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
reversible: false
reactant: MODEL1310110004#
type: Reaction
fast: false
kinetic law: MODEL1310110004#

metaR FAOXC121x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

metaR r1606
product: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_ac748df8_7988_4924_84d8_b16e02a0dfe3
has only substance units: false
is: E9PCP2
type: Species
initial concentration: NaN
initial amount: NaN
name: CPT1B
boundary condition: true
is encoded by: hsa:1375
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_31fdb6a7_b35b_4666_a4e5_b4bb09ff51a5
is: SBO:0000252
constant: false
is encoded by: hsa:250
type: Species
name: ALPP
initial concentration: NaN
has only substance units: false
is: P05187
boundary condition: true
initial amount: NaN

metaR r2317
reversible: true
fast: false
kinetic law: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

metaR r2314
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110004#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110004#
fast: false

metaR r0642
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110004#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
is described by: ECO:0000000
product: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_b46be289_06b8_4a8b_9e71_2f0651640393
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: MAOA
is: Q53YE7
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:4128

metaR SCP2x
name: peroxisomal thiolase 2
reversible: false
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways version 2 analog added as per KEGG NJ
modifier: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.176
type: Reaction
is described by: ECO:0000269
product: MODEL1310110004#

metaM nrpphrsf c
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
name: Sulfate derivative of norepinephrine
is: SBO:0000247
is: HMDB02062
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/123747

metaR EICOSTETt
type: Reaction
is described by: ECO:0000000
product: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
fast: false
name: fatty acid transport via diffusion
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110004#

metaM acglcgalgbside hs g
name: GlcNAc-Gal globoside
type: Species
boundary condition: false
is: CHEBI:26174
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
initial amount: NaN
constant: false

metaM HC01603 c
has only substance units: false
is: CHEBI:57454
initial concentration: 1.0
boundary condition: false
name: 10-Formyltetrahydrofolate
type: Species
initial amount: NaN
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
is: C00234
is: SBO:0000247

metaM o2 r
constant: false
is: CHEBI:15379
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
initial amount: NaN
name: O2
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB01377

metaR GLRASE
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110004#
type: Reaction
name: glucuronolactone reductase
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110004#

metaR r1607
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110004#
is: SBO:0000185
reversible: true
reactant: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_b218fb56_2286_4dfd_af75_fe8ae8a51a9c
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
name: PDE9A
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5152

metaR M13N2Tg
reversible: false
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.101
product: MODEL1310110004#
is: SBO:0000176
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
kinetic law: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#

metaR ORNt4m
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
modifier: MODEL1310110004#
fast: false
is: SBO:0000185
product: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
type: Reaction
is described by: ECO:0000269
name: ornithine mitochondrial transport exchange with citruline
reactant: MODEL1310110004#

metaR r0641
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
type: Reaction
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.2.4
reactant: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000000

metaR r2315
reactant: MODEL1310110004#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_b25f4b2d_70f4_4b52_95f7_d8f7e05cd917
is encoded by: hsa:6560
constant: false
is: F5H066
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: SLC12A4
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_e89b9cdb_4764_4b71_b43c_08cd1b9b94e5
is: P23921
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: RRM1
is encoded by: hsa:6240
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_93822fc9_4557_44a6_8a99_13331b5a2643
name: ATP1A3:ATP1B2
constant: false
has part: P14415
is encoded by: hsa:482
initial amount: NaN
initial concentration: NaN
is: SBO:0000297
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_fe9dafe2_6380_4c4a_afda_e9bda7963de1
is: P24298
is encoded by: hsa:2875
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
name: GPT
initial concentration: NaN

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaM ala B c
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
initial concentration: 1.0
is: CHEBI:16958
is: HMDB00056
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_2e100c66_54cb_435c_8063_db770c3c2f8a
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:203
boundary condition: true
is: SBO:0000252
name: AK1
is: P00568

metaR TSTSTERONEtr
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110004#
fast: false
type: Reaction
name: testosterone intracellular transport
product: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_9bf5e2e2_6ef1_4637_bb17_70ccd037c226
is: O95427
name: PIGN
is: SBO:0000252
is encoded by: hsa:23556
boundary condition: true
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
has only substance units: false

metaR PAPStg
is: SBO:0000185
modifier: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
name: 3'-Phosphoadenylyl sufate Golgi transport
is described by: ECO:0000269
reactant: MODEL1310110004#
reversible: true
fast: false

metaR EX c6crn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hexanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_eceabe72_a307_47c0_9aa4_ecd309583ee8
is encoded by: hsa:79369
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: Q9C0J1
is: SBO:0000252
name: B3GNT4
initial amount: NaN

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR r1608
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110004#
is described by: ECO:0000000
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110004#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_e5ef451b_5e19_4073_82ba_f36404135a9a
initial concentration: NaN
is: O14561
boundary condition: true
name: NDUFAB1
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:4706

metaM pac c
initial concentration: 1.0
constant: false
is: CHEBI:18401
type: Species
is: HMDB00209
name: phenylacetate
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR PROt4
reactant: MODEL1310110004#
name: Na+/Proline-L symporter
is described by: ECO:0000269
modifier: MODEL1310110004#
reversible: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (55089.1) or (81539.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
is: SBO:0000185
type: Reaction
fast: false

metaR IZPN
type: Reaction
name: Imidazolonepropionase
kinetic law: MODEL1310110004#
is: SBO:0000176
reversible: false
reactant: MODEL1310110004#
is described by: ECO:0000000
fast: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM arachdcrn x
boundary condition: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
is: SBO:0000247
is: HMDB01064
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5462164
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_651ba20f_d08c_4d1e_8be4_9c131e3a53a5
type: Species
is: SBO:0000252
is: Q5SYN6
is encoded by: hsa:6581
initial concentration: NaN
boundary condition: true
name: SLC22A3
initial amount: NaN
constant: false
has only substance units: false

metaR r1609
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
fast: false

metaM succ m
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:30031
is: C00042
is: SBO:0000247
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: HMDB00254
boundary condition: false
name: Succinate
initial amount: NaN
has only substance units: false

metaR FAOXC11C9m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

metaM gdp n
initial amount: NaN
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: GDP(3-)
is: CHEBI:58189
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_08b3b4b1_c034_49de_9fef_44186efb0c80
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: O00142
is encoded by: hsa:7084
constant: false
has only substance units: false
boundary condition: true
name: TK2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_b1d919d3_c11e_4833_82fe_8b33de759a51
is encoded by: hsa:3098
has only substance units: false
is: Q59FD4
type: Species
name: HK1
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaM o2 n
type: Species
is: HMDB01377
initial concentration: 1.0
name: dioxygen
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
boundary condition: false
is: CHEBI:15379

metaM 3hodcoa m
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: http://identifiers.org/pubchem.compound/5280355
boundary condition: false
constant: false
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
type: Species
name: (S)-3-Hydroxyoctadecanoyl-CoA

metaR LEUKTRA4t
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000269
is: SBO:0000185
name: leukotriene A4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
reversible: true
fast: false
reactant: MODEL1310110004#
type: Reaction

metaR r0647
reactant: MODEL1310110004#
name: Spontaneous reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110004#
type: Reaction
product: MODEL1310110004#

metaM gdp m
type: Species
name: GDP
is: SBO:0000247
is: C00035
constant: false
is: HMDB01201
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false
boundary condition: false
is: CHEBI:58189
initial concentration: 1.0
initial amount: NaN

metaM ala B e
type: Species
is: CHEBI:16958
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00056
name: beta-alanine
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_6e824e77_47c4_40ec_a7dd_396d32d68b77
has only substance units: false
boundary condition: true
is encoded by: hsa:23533
initial concentration: NaN
initial amount: NaN
constant: false
name: PIK3R5
type: Species
is: SBO:0000252
is: Q8WYR1

metaM o2 m
has only substance units: false
boundary condition: false
is: CHEBI:15379
constant: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial concentration: 1.0
initial amount: NaN
name: O2
is: C00007
is: SBO:0000247
is: HMDB01377
type: Species

metaM 7thf c
is: HMDB00032
initial amount: NaN
name: heptaglutamyl folate (THF)
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
notes: FORMULA: C49H57N13O24 CHARGE: -8
is: CHEBI:17759
is: SBO:0000247
boundary condition: false

metaM ksii core4 g
name: keratan sulfate II (core 4-linked)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:57255
initial concentration: 1.0
constant: false
is: HMDB01014

metaR GLCNACASE5ly
reversible: false
product: MODEL1310110004#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.50
fast: false
type: Reaction
reactant: MODEL1310110004#
is: SBO:0000176
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
name: alpha-N-acetylglucosaminidase, lysosomal

metaR O2ter
is described by: ECO:0000000
name: O2 transport, endoplasmic reticulum
product: MODEL1310110004#
is: SBO:0000185
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
reactant: MODEL1310110004#
fast: false

metaM Asn X Ser Thr l
constant: false
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
name: protein-linked asparagine residue (N-glycosylation site)
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28938
is: HMDB00051
is: C01342
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_c1ddbc1b_532c_40e2_8d5e_7a5bc37d80a2
has part: Q9NS82
name: SLC7A10:SLC3A2
type: Species
initial concentration: NaN
is encoded by: hsa:56301
has only substance units: false
is encoded by: hsa:6520
is: SBO:0000297
initial amount: NaN
boundary condition: true
constant: false
has part: P08195

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_66ae1bc0_3988_4382_88ac_d1452df0db3a
name: RPL36A
has only substance units: false
is encoded by: hsa:6173
initial amount: NaN
boundary condition: true
is: P83881
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaM galgluside hs g
initial amount: NaN
boundary condition: false
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
constant: false
is: HMDB00295
has only substance units: false
is: SBO:0000247
is: C00015
type: Species
name: galactosyl glucosyl ceramide
is: CHEBI:58223
initial concentration: 1.0

metaR r2318
product: MODEL1310110004#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110004#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_a9bb0da6_7250_4e77_a62b_275f6f8738e8
is: SBO:0000252
name: SLC17A3
is: O00476
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:10786
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_eec9749b_9dbe_4e0d_8cf4_945da46cf836
initial amount: NaN
initial concentration: NaN
name: MGAT2
is: Q10469
boundary condition: true
has only substance units: false
is encoded by: hsa:4247
type: Species
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_299402c0_bdb5_4455_ae89_db283df7bb06
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P19174
boundary condition: true
is encoded by: hsa:5335
constant: false
initial concentration: NaN
name: PLCG1
type: Species

metaR NRPPHRSFt
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110004#
fast: false
name: norepinephrine sulfate transport (diffusion)
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaM ptdcacrn c
name: pendtadenoyl carnitine
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
initial concentration: 1.0
is: CHEBI:18303
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN

metaR RETH
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110004#
name: retinyl ester hydrolase
kinetic law: MODEL1310110004#
is: SBO:0000176
fast: false
product: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.1.3
reversible: false
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT

metaR GLACter
product: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
reversible: true
kinetic law: MODEL1310110004#
type: Reaction
fast: false
reactant: MODEL1310110004#

metaR r2319
fast: false
reversible: true
kinetic law: MODEL1310110004#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_0e90dd55_7be5_43d0_91c6_abe31dfc8c20
has part: Q99519
has part: P16278
is encoded by: hsa:2588
type: Species
initial amount: NaN
is: SBO:0000297
has part: P10619
constant: false
is encoded by: hsa:5476
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4758
name: GALNS:GLB1:NEU1:CTSA
has part: P34059
is encoded by: hsa:2720

metaR FAOXC142C122m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

metaR Htr
kinetic law: MODEL1310110004#
reversible: true
is described by: ECO:0000000
product: MODEL1310110004#
is: SBO:0000185
reactant: MODEL1310110004#
name: H transporter, endoplasmic reticulum
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaR TETDECE1CRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tetradecenoyl carnitine into extra cellular space
type: Reaction

metaM tetpent6coa x
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: tetracosapentaenoyl coenzyme A, n-6
is: C16172
type: Species
initial concentration: 1.0
constant: false
has only substance units: false

metaR FAOXC12C12OHm
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

metaR r0539
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
type: Reaction
modifier: MODEL1310110004#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
reversible: true
product: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.34
reactant: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#

metaR FAOXC2442246x
is version of: http://identifiers.org/ec-code/4.2.1.107
notes: GENE_ASSOCIATION: (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c24:4,n-6 -> c22:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reversible: false
product: MODEL1310110004#
reactant: MODEL1310110004#
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000269

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM ksii core4 e
type: Species
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial amount: NaN
name: keratan sulfate II (core 4-linked)
is: HMDB00211
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:17268
has only substance units: false

metaM 7thf e
type: Species
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C49H57N13O24 CHARGE: -8
initial amount: NaN
is: HMDB06559
name: heptaglutamyl folate (THF)
initial concentration: 1.0
is: SBO:0000247

metaR FAOXC205C184x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

metaM g2m8mpdol U r
boundary condition: false
initial amount: NaN
is: CHEBI:59093
type: Species
initial concentration: 1.0
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_e0ccfcfd_0dec_4c91_b655_b68b31e70605
constant: false
boundary condition: true
initial concentration: NaN
is: Q8TB61
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: SLC35B2
is encoded by: hsa:347734
type: Species

metaM chol c
is: SBO:0000247
boundary condition: false
is: HMDB00097
type: Species
name: Choline
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial amount: NaN
is: C00114
constant: false
has only substance units: false
is: CHEBI:15354
initial concentration: 1.0

metaM hxcoa c
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: Hexanoyl-CoA (n-C6:0CoA)
notes: FORMULA: C27H42N7O17P3S CHARGE: -4
is: SBO:0000247
type: Species
is: HMDB13130
constant: false

metaM dgtp c
is: CHEBI:16497
type: Species
is: SBO:0000247
initial concentration: 1.0
is: C00286
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
boundary condition: false
name: dGTP
initial amount: NaN
has only substance units: false
is: HMDB01440

http://identifiers.org/biomodels.db/MODEL1310110004#_c50511a6_43c7_43ea_8189_2eab18739706
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:284129
is: Q86WA9
initial concentration: NaN
name: SLC26A11
type: Species
has only substance units: false
is: SBO:0000252

metaM lneldccrn c
initial amount: NaN
is: SBO:0000247
name: Linoelaidyl carnitine
has only substance units: false
boundary condition: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
constant: false
initial concentration: 1.0
type: Species
is: HMDB06461

http://identifiers.org/biomodels.db/MODEL1310110004#_ce272760_a200_4f61_803a_89ab8be237eb
boundary condition: true
type: Species
name: MYO5B
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:4645
initial concentration: NaN
is: Q9H6Y6

http://identifiers.org/biomodels.db/MODEL1310110004#_ae3e81f2_543b_46fc_9d25_003244830517
type: Species
initial concentration: NaN
boundary condition: true
name: ACSS2
constant: false
initial amount: NaN
is: Q5QPH3
has only substance units: false
is: SBO:0000252
is encoded by: hsa:55902

http://identifiers.org/biomodels.db/MODEL1310110004#_56e2a062_ba6b_4579_8924_c2ca30d41869
initial amount: NaN
name: ACSL4
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2182
is: SBO:0000252
is: O60488
boundary condition: true

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_f85d046d_00a3_4e98_a694_a57699a5f511
boundary condition: true
initial amount: NaN
is: Q12882
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1806
constant: false
has only substance units: false
name: DPYD
type: Species

metaR UMPKn
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
name: UMP kinase, nuclear

metaR PSt3
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000269
fast: false
is: SBO:0000185
type: Reaction
reactant: MODEL1310110004#
name: phosphatidylserine transport

http://identifiers.org/biomodels.db/MODEL1310110004#_746b6109_4063_4c22_8ba1_c1c6e936799e
is encoded by: hsa:4729
boundary condition: true
initial concentration: NaN
name: NDUFV2
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is: P19404

metaR FAOXC12DCx
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_7b6bd257_7d99_4fd1_b9ab_2ab194d48c2f
has only substance units: false
name: SLC7A6
initial amount: NaN
type: Species
is: Q92536
boundary condition: true
initial concentration: NaN
is encoded by: hsa:9057
constant: false
is: SBO:0000252

metaM c10dc x
initial concentration: 1.0
name: sebacoyl carnitine
notes: FORMULA: C17H30NO6 CHARGE: -1
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00651

metaR SIAASE2ly
product: MODEL1310110004#
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
name: sialidase, lysosomal
kinetic law: MODEL1310110004#
is described by: ECO:0000000
modifier: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176

metaM hdca r
is: CHEBI:7896
is: C00249
name: Hexadecanoate (n-C16:0)
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_48ba3210_40bd_4090_aabb_ea5a82b2a69e
initial amount: NaN
name: _R51273_1_c
has only substance units: false
constant: false
is encoded by: hsa:R51273
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true

metaR PNTEH
reactant: MODEL1310110004#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
modifier: MODEL1310110004#
is described by: ECO:0000269
product: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
reversible: false
name: Hydrolase Class ( RXN R02973)
is version of: http://identifiers.org/ec-code/3.5.1.92

http://identifiers.org/biomodels.db/MODEL1310110004#_ca4cde48_7cab_4025_9fa8_b772040fbc02
has only substance units: false
initial amount: NaN
type: Species
name: PRPS1L1
initial concentration: NaN
is encoded by: hsa:221823
constant: false
boundary condition: true
is: P21108
is: SBO:0000252

metaM cys L c
boundary condition: false
constant: false
name: L-cysteine
type: Species
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: HMDB00574
initial amount: NaN
is: CHEBI:17561
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM pail5p hs n
initial amount: NaN
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_1d334bcd_0dd8_437b_9315_1a042d5f8b53
is encoded by: hsa:4758
is: Q99519
name: NEU1
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252

metaM dgtp e
is: HMDB01440
is: SBO:0000247
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:16497
boundary condition: false
initial amount: NaN
name: dGTP

metaM adpcoa c
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: HMDB04047
initial amount: NaN
has only substance units: false
type: Species
name: adipoylcoa
is: C14143
boundary condition: false

metaM akg x
is: SBO:0000247
boundary condition: false
is: HMDB00208
type: Species
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
has only substance units: false
initial amount: NaN
is: CHEBI:16810
name: 2-oxoglutarate(2-)
constant: false
initial concentration: 1.0

metaM C02528 c
boundary condition: false
is: HMDB00518
initial concentration: 1.0
name: chenodeoxycholate
has only substance units: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: CHEBI:36234
constant: false
type: Species
is: SBO:0000247
initial amount: NaN

metaR BHBt
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110004#
name: (R)-3-Hydroxybutanoate transport via H+ symport

metaR ILEt5m
product: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
name: Isoleucine mitochondrial transport
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_5e879a50_a1bf_4e3f_86d2_d746836ede6b
constant: false
has only substance units: false
is: P30084
type: Species
name: ECHS1
initial amount: NaN
is encoded by: hsa:1892
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR Htx
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
name: H transporter, peroxisome
fast: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

metaM nrpphrsf e
initial amount: NaN
notes: FORMULA: C8H11NO6S CHARGE: 0 INCHI: InChI=1/C8H11NO6S/c9-4-7(11)5-1-2-8(6(10)3-5)15-16(12,13)14/h1-3,7,10-11H,4,9H2,(H,12,13,14)/t7-/m0/s1
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB02062
is: http://identifiers.org/pubchem.compound/123747
name: Sulfate derivative of norepinephrine
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_93758a59_9206_4993_ba1b_3bb6bfb5300b
initial concentration: NaN
is encoded by: hsa:3631
type: Species
is: SBO:0000252
name: INPP4A
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false

metaM hdca l
initial concentration: 1.0
name: palmitate
has only substance units: false
initial amount: NaN
is: CHEBI:7896
constant: false
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00220

metaM dd2coa m
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: HMDB03712
has only substance units: false
is: CHEBI:57330
name: trans-dodec-2-enoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110004#_c72eea42_3c9c_4bf3_9c76_02c8a7c6f972
type: Species
initial concentration: NaN
is: O43677
name: NDUFC1
is encoded by: hsa:4717
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN

metaM CE2420 m
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
initial amount: NaN
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
has only substance units: false
initial concentration: 1.0
is: CHEBI:28387
is: HMDB11123
boundary condition: false

metaM ksi deg3 l
initial concentration: 1.0
boundary condition: false
type: Species
name: keratan sulfate I, degradation product 3
has only substance units: false
is: SBO:0000247
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
is: HMDB00573
constant: false
initial amount: NaN
is: CHEBI:30825

http://identifiers.org/biomodels.db/MODEL1310110004#_4d22f3d8_eea2_4d27_b298_ec224d90e919
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: G6PC2
is encoded by: hsa:57818
constant: false
initial amount: NaN
boundary condition: true
is: E9PAX2

metaM lneldc e
boundary condition: false
is: HMDB06270
initial concentration: 1.0
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
name: linoelaidic acid (all trans C18:2)
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
type: Species

metaR DHCR71r
is version of: http://identifiers.org/ec-code/1.3.1.21
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is described by: ECO:0000134
product: MODEL1310110004#
modifier: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: false
name: 7-dehydrocholesterol reductase
fast: false

metaM HC01231 c
constant: false
type: Species
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: CHEBI:58480
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: N-[(R)-pantothenoyl]-L-cysteinate
boundary condition: false

metaM phytcoa c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
type: Species
name: phytanoyl-CoA(4-)
is: CHEBI:57391
is: SBO:0000247
is: HMDB01359
has only substance units: false
constant: false

metaM cys L e
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00574
initial amount: NaN
name: L-cysteine
boundary condition: false
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: CHEBI:17561
is: SBO:0000247
constant: false

metaR FAOXTC122TC101m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C12:2-->C10:1)m
type: Reaction

metaM ptdcacrn m
is: CHEBI:18303
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
name: pendtadenoyl carnitine
has only substance units: false

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_46595e5b_4dc1_4d20_981c_e067028d04af
initial concentration: NaN
is: F8WAB8
type: Species
constant: false
has only substance units: false
is encoded by: hsa:115286
initial amount: NaN
is: SBO:0000252
name: SLC25A26
boundary condition: true

metaR BTND1
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:IT
name: biotinidase (biotin)
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.5.1.12
product: MODEL1310110004#

metaM pmtcrn r
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
constant: false
is: SBO:0000247
initial concentration: 1.0
name: L-palmitoylcarnitine
has only substance units: false
is: CHEBI:17490
boundary condition: false
is: HMDB00222
initial amount: NaN
type: Species

metaR BTNt2
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
name: Biotin reversible transport via proton symport
reversible: true
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
fast: false
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_c0bd3014_3191_4101_ae0d_293778100e74
has only substance units: false
constant: false
initial amount: NaN
is: B4DNK4
is encoded by: hsa:5315
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: PKM2

metaR THRGLNexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110004#
name: L-threonine/glycine reversible exchange
kinetic law: MODEL1310110004#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
is described by: ECO:0000304
fast: false

metaM succ c
is: SBO:0000247
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: CHEBI:30031
is: C00042
is: HMDB00254
initial concentration: 1.0
initial amount: NaN
name: Succinate
has only substance units: false
boundary condition: false
type: Species

metaM udpacgal l
is: SBO:0000247
boundary condition: false
is: HMDB00304
has only substance units: false
name: UDP-N-acetyl-D-galactosamine(2-)
is: CHEBI:57847
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN

metaR RE1807M
name: RE1807
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110004#
product: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.14.13.15
reactant: MODEL1310110004#
is: SBO:0000176
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

metaR RE0344C
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
product: MODEL1310110004#
is described by: ECO:0000000
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
name: RE0344
is version of: http://identifiers.org/ec-code/2.3.1.65
modifier: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_f876f38f_3bda_43a4_b6a6_157c38798f09
initial amount: NaN
boundary condition: true
is encoded by: hsa:9061
is: O43252
initial concentration: NaN
constant: false
has only substance units: false
name: PAPSS1
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_cda013d6_2dfa_42fe_8aca_7649b56165a0
constant: false
has only substance units: false
type: Species
boundary condition: true
is: P52790
name: HK3
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3101

http://identifiers.org/biomodels.db/MODEL1310110004#_4e733695_7c14_4f4d_bf46_2d89a254a768
constant: false
is: O75874
has only substance units: false
name: IDH1
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:3417
initial concentration: NaN

metaM o2 e
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
name: O2
has only substance units: false
is: SBO:0000247
is: CHEBI:15379
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01377

metaR ACt2r
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
fast: false
reactant: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
name: acetate reversible transport via proton symport
product: MODEL1310110004#
is: SBO:0000185

metaM lneldc c
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+
is: HMDB06270
initial concentration: 1.0
name: linoelaidic acid (all trans C18:2)
has only substance units: false
initial amount: NaN
constant: false

metaM 3hodcoa c
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
name: (S)-3-Hydroxyoctadecanoyl-CoA
initial amount: NaN
has only substance units: false
is: HMDB13336

http://identifiers.org/biomodels.db/MODEL1310110004#_6240fdcb_398b_48e7_b5ad_be9b9ab50dc0
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5152
has only substance units: false
name: PDE9A

metaR SARCStex
is: SBO:0000185
reactant: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:5096515 NOTES:MM
name: Sarcosine transport (extracellular to cytosol)
product: MODEL1310110004#
fast: false
reversible: false
type: Reaction

metaM chol e
boundary condition: false
is: HMDB00097
initial concentration: 1.0
initial amount: NaN
is: C00114
type: Species
has only substance units: false
is: CHEBI:15354
is: SBO:0000247
constant: false
name: Choline
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114

metaM CE2838 e
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: C01936
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
type: Species
name: maltononaose

metaR FAOXC14C12x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_ec2481c8_1c5f_4a90_9b1f_b9bfaef571e8
has only substance units: false
initial concentration: NaN
is: Q8N3E9
is encoded by: hsa:113026
type: Species
is: SBO:0000252
boundary condition: true
constant: false
name: PLCD3
initial amount: NaN

metaR r0801
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_0f8e0e3b_76da_4f74_a878_02ef718aa4b0
has part: P56385
is encoded by: hsa:9551
has part: Q08ET0
has part: P05496
has part: O75964
initial concentration: NaN
is encoded by: hsa:515
is encoded by: hsa:10476
has part: Q6IBB3
has part: A0PJH2
is encoded by: hsa:521
has part: P46459
is encoded by: hsa:522
is encoded by: hsa:10632
constant: false
is encoded by: hsa:4905
is: SBO:0000297
initial amount: NaN
boundary condition: true
name: ATP5H:ATP5L:NSF:ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:516
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_6569db9d_72e4_4c39_9c57_e7d61d876aff
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P54819
is encoded by: hsa:204
boundary condition: true
name: AK2

metaM 3aib D c
name: D-3-Amino-isobutanoate
initial amount: NaN
is: SBO:0000247
is: HMDB02299
type: Species
is: C03265
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
constant: false

metaM ksi pre19 g
is: SBO:0000247
is: CHEBI:58053
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
name: keratan sulfate I biosynthesis, precursor 19
initial concentration: 1.0
has only substance units: false
is: HMDB00175
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: C00130

metaM glcur c
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:15748
boundary condition: false
name: D-glucuronate
constant: false

metaM arachdcrn c
constant: false
name: C20:4 carnitine
is: HMDB01322
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
is: SBO:0000247
is: CHEBI:57387

metaM xu5p D c
initial concentration: 1.0
is: CHEBI:57737
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
type: Species
has only substance units: false
boundary condition: false
name: D-xylulose 5-phosphate(2-)
constant: false
is: HMDB00868
is: SBO:0000247
initial amount: NaN

metaM trdox c
is: CHEBI:18191
name: Oxidized thioredoxin
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: C00343
type: Species
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial amount: NaN

metaR PI45PLC
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
modifier: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.4.11
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000176
reversible: false

metaM c226coa m
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205479
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: C16169
type: Species
name: cervonyl coenzyme A

metaM dgtp n
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:16497
is: HMDB01440
name: dGTP
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: C00286
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286

http://identifiers.org/biomodels.db/MODEL1310110004#_df414853_d973_434b_9383_631241cd0fbd
is: F6KD01
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
name: PTEN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5728

http://identifiers.org/biomodels.db/MODEL1310110004#_51a8f309_da72_4c46_9074_75bad776bcf6
is: Q1EHB4
is encoded by: hsa:159963
initial amount: NaN
name: SLC5A12
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false

metaR GALASE5ly
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
reactant: MODEL1310110004#
name: beta-galactosidase, lysosomal
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
fast: false

metaR r2443
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110004#
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
is described by: ECO:0000000
reactant: MODEL1310110004#
product: MODEL1310110004#
reversible: false

metaR FACOAL2042
reactant: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
modifier: MODEL1310110004#
product: MODEL1310110004#
fast: false
reversible: true
kinetic law: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM tdcoa x
name: Tetradecanoyl-CoA (n-C14:0CoA)
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: C02593
is: HMDB01521
boundary condition: false
is: CHEBI:57385
constant: false
type: Species

metaM glac r
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
boundary condition: false
name: D-glucurono-6,3-lactone
type: Species
has only substance units: false
is: CHEBI:18268
constant: false
is: HMDB06355

metaM 2docohexecoa m
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
type: Species
is: http://identifiers.org/pubchem.compound/24892790
name: 2,7,10,13,16,19-docosahexenoylcoa
boundary condition: false
is: SBO:0000247

metaR DPMVDx
kinetic law: MODEL1310110004#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.1.33 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is version of: http://identifiers.org/ec-code/4.1.1.33
modifier: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110004#
type: Reaction
name: diphosphomevalonate decarboxylase

metaR FAOXC123m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

metaR FAOXC101C8x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8:0)x
type: Reaction

metaR RE3565C
kinetic law: MODEL1310110004#
name: RE3565
fast: false
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
product: MODEL1310110004#
reactant: MODEL1310110004#

metaM lys L c
constant: false
is: HMDB00182
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551
initial concentration: 1.0
boundary condition: false
name: L-lysinium(1+)

metaR MI1PP
fast: false
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
product: MODEL1310110004#
reversible: false
name: myo-inositol 1-phosphatase
kinetic law: MODEL1310110004#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.3.25
is described by: ECO:0000269

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaM galgbside hs g
initial concentration: 1.0
constant: false
is: CHEBI:18259
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0
boundary condition: false
has only substance units: false
name: galactosylgloboside

metaR NDP7g
name: nucleoside-diphosphatase (UDP), Golgi apparatus
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.6
reactant: MODEL1310110004#
type: Reaction
reversible: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (9583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:10393803,PMID:10858452,PMID:9556635 NOTES:NCD
is: SBO:0000176
product: MODEL1310110004#
modifier: MODEL1310110004#

metaM mi34p c
constant: false
is: HMDB06235
initial amount: NaN
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)4(10)6(18-20(14,15)16)5(3(1)9)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C04063
name: 1D-myo-Inositol 3,4-bisphosphate
is: CHEBI:28858
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM CE5869 e
name: lysyl-proline
notes: FORMULA: C11H22N3O3 CHARGE: 1 INCHI: InChI=1/C11H21N3O3/c12-6-2-1-4-8(13)10(15)14-7-3-5-9(14)11(16)17/h8-9H,1-7,12-13H2,(H,16,17)/p+1/t8-,9-/m1/s1 EHMN_ABBREVIATION: CE5869
has only substance units: false
constant: false
is: HMDB02710
is: SBO:0000247
is: CHEBI:27485
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_2850f508_a37b_403b_a5cc_c220377be37f
name: COX8A
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q53XN1
type: Species
constant: false
has only substance units: false
is encoded by: hsa:1351
initial concentration: NaN

metaM 7thf l
is: HMDB00032
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17759
initial amount: NaN
type: Species
notes: FORMULA: C49H57N13O24 CHARGE: -8
name: heptaglutamyl folate (THF)

metaM tetdece1crn c
initial amount: NaN
type: Species
notes: FORMULA: C21H39NO4 CHARGE: 0
is: SBO:0000247
name: tetradecenoyl carnitine
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB02014
boundary condition: false

metaR RE1525M
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110004#
is: SBO:0000176
modifier: MODEL1310110004#
name: RE1525
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_239b9258_5527_40c2_b40c_fd6328b02dd3
name: DPM2
has only substance units: false
is: O94777
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:8818
type: Species
constant: false
initial concentration: NaN

metaR r1147
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110004#
type: Reaction
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110004#
is: SBO:0000185
product: MODEL1310110004#
is described by: ECO:0000000

metaM hepcoa m
is: HMDB12969
boundary condition: false
name: heptanoylcoa
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C28H44N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_58339941_2b75_470e_952b_8b3feb093495
type: Species
constant: false
name: AHCY
is: B3KUN3
has only substance units: false
initial concentration: NaN
is encoded by: hsa:191
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM cdpdag hs m
boundary condition: false
type: Species
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
name: CDP-diacylglycerol(2-)
is: CHEBI:58332
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false

metaM 2decdicoa x
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247
initial concentration: 1.0
constant: false
name: 2,7-decadienoylcoa

metaR EX tettet6 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosatetraenoic acid n-6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_dc6c7688_e50c_4cbf_8142_dd155c095ac0
is: SBO:0000252
name: PLCB1
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q9NQ66
constant: false
is encoded by: hsa:23236
type: Species
has only substance units: false

metaM lys L e
is: HMDB00182
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: CHEBI:32551
boundary condition: false
initial concentration: 1.0
constant: false
name: L-lysinium(1+)

http://identifiers.org/biomodels.db/MODEL1310110004#_273789cf_72f3_4c2b_9eca_74d03637a163
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1892
initial amount: NaN
name: ECHS1
constant: false
has only substance units: false
is: SBO:0000252
is: P30084

metaM 7thf m
has only substance units: false
is: SBO:0000247
is: CHEBI:17759
name: heptaglutamyl folate (THF)
is: HMDB00032
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C49H57N13O24 CHARGE: -8
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_6340142d_692f_4524_ae5a_e62449764734
initial concentration: NaN
boundary condition: true
name: PNPO
constant: false
type: Species
is encoded by: hsa:55163
has only substance units: false
is: Q9NVS9
is: SBO:0000252
initial amount: NaN

metaR r1148
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
name: Active transport
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110004#

metaM dolglcp U c
is: CHEBI:15812
constant: false
boundary condition: false
initial concentration: 1.0
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false

metaR EX CE5869 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lysyl-proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_9fd4de12_4759_4cda_a2ed_40a4cd947081
initial concentration: NaN
name: FLAD1
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:80308
boundary condition: true
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_4bb8eb15_723e_44af_b6bb_1939dedbe151
is encoded by: hsa:50814
has only substance units: false
initial concentration: NaN
constant: false
name: NSDHL
is: Q15738
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN

metaM val L m
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
is: SBO:0000247
is: CHEBI:16414
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
name: L-valine
has only substance units: false
is: HMDB00883

http://identifiers.org/biomodels.db/MODEL1310110004#_1bd439ab_4bf8_48b6_a0f4_b7056c88303c
has only substance units: false
type: Species
is: Q7KYS4
name: PDE4C
constant: false
initial amount: NaN
is encoded by: hsa:5143
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR CYTK3n
kinetic law: MODEL1310110004#
fast: false
modifier: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
name: cytidylate kinase (dCMP,CTP),nuclear
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110004#
reversible: true
is described by: ECO:0000269

metaR FAOXC180
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110004#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
fast: false
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_0b8184e1_aef3_4e64_9915_763b8a17f9f2
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: MGAT3
boundary condition: true
initial amount: NaN
is encoded by: hsa:4248
type: Species
constant: false
is: Q09327

metaM tetdece1crn e
notes: FORMULA: C21H39NO4 CHARGE: 0
type: Species
is: HMDB02014
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: tetradecenoyl carnitine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_fb162a03_8307_4be3_82ef_ae5129c955f5
has only substance units: false
is: Q02338
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: BDH1
is encoded by: hsa:622
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_1f3f2ba6_69cc_446f_9512_251e02fc1b93
type: Species
initial concentration: NaN
is encoded by: hsa:84889
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q8WY07
is: SBO:0000252
name: SLC7A3
constant: false

metaM nrvnc c
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:32392
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
is: HMDB02368
initial amount: NaN
name: nervonate

http://identifiers.org/biomodels.db/MODEL1310110004#_ad185baf_ab1b_4107_9878_a403084242e4
is encoded by: hsa:2821
constant: false
name: GPI
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: P06744
boundary condition: true
initial concentration: NaN
type: Species

metaR SERGLNexR
reversible: true
product: MODEL1310110004#
is: SBO:0000185
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110004#
is described by: ECO:0000304
type: Reaction
fast: false
name: L-Serine/Glutamine reversible exchange
kinetic law: MODEL1310110004#

metaM 3hexdcoa m
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB03932
type: Species
is: C05258
initial amount: NaN
name: 3-hydroxyhexadecanoylcoa
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_5819e2b2_4bf3_448f_afc9_ae1376904fa4
boundary condition: true
name: PDE7A
type: Species
is: Q13946
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5150
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_2d2bbb3d_8007_4437_8d1b_827e49bc33ab
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: PDE9A
is encoded by: hsa:5152
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_12f9789a_7ac2_41cd_8e62_a7b051efd0df
boundary condition: true
type: Species
name: _H53099_1_m
has only substance units: false
is encoded by: hsa:H53099
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR CHOLt4
reversible: true
name: choline, sodium cotransport
is described by: ECO:0000269
modifier: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
reactant: MODEL1310110004#
fast: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction

metaR C162ACBP
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_fcf513be_6512_4e8e_a460_bf5bbff81843
is: P17174
name: GOT1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2805
constant: false
initial amount: NaN
boundary condition: true
type: Species

metaR C14STRr
name: C-14 sterol reductase
reversible: false
fast: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.1.70
reactant: MODEL1310110004#
is described by: ECO:0000134
type: Reaction
modifier: MODEL1310110004#
is: SBO:0000176

metaM 3ttetddcoa m
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
name: 3-hydroxy trans5,8tetradecadienoyl coa
is: HMDB02014
boundary condition: false
initial concentration: 1.0

metaR r1030
name: Transport reaction
fast: false
product: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110004#
is: SBO:0000185

metaR C4STMO2r
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.170
notes: GENE_ASSOCIATION: (6307.1) or (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
reversible: false
name: C-4 methyl sterol oxidase
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.13.72
reactant: MODEL1310110004#

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaR r1764
is described by: ECO:0000000
product: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110004#
reversible: false
name: Y+LAT2 Utilized transport
type: Reaction
modifier: MODEL1310110004#

metaR DOLGLCP Lter
is: SBO:0000185
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
name: Dolichyl beta-D-glucosyl phosphate flippase (liver)
type: Reaction
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110004#
fast: false

metaM nrvnc e
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB02368
has only substance units: false
initial concentration: 1.0
is: CHEBI:32392
initial amount: NaN
notes: FORMULA: C24H45O2 CHARGE: -1 INCHI: InChI=1S/C24H46O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h9-10H,2-8,11-23H2,1H3,(H,25,26)/p-1/b10-9-
name: nervonate

metaM cholcoa c
is: CHEBI:57373
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01374
name: choloyl-CoA(4-)
has only substance units: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
boundary condition: false

metaR NACHEX26ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110004#
reversible: false
fast: false
kinetic law: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_f5012669_8199_4dc0_bddc_0e1857654945
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: O00746
has only substance units: false
constant: false
name: NME4
boundary condition: true
is encoded by: hsa:4833

metaM tetpent3 e
boundary condition: false
is: SBO:0000247
is: HMDB06323
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
name: tetracosapentaenoic acid, n-3
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaR VACCt
is: SBO:0000185
reversible: true
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
fast: false
name: fatty acid transport via diffusion
is described by: ECO:0000000

metaR HACD1m
modifier: MODEL1310110004#
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
reversible: true
kinetic law: MODEL1310110004#
is: SBO:0000176
fast: false
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110004#_b6950425_a9cc_4263_a120_844175e1a3b5
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ACSS1
is encoded by: hsa:84532
type: Species
is: Q9NUB1

http://identifiers.org/biomodels.db/MODEL1310110004#_bcf5996d_5bf0_4776_a4c4_d3598edc7169
constant: false
initial concentration: NaN
is: Q96KJ9
name: COX4I2
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:84701
type: Species

metaM HC00250 e
is: CHEBI:29919
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
name: hydrosulfide
is: SBO:0000247
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
constant: false

metaM hom L e
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00719
constant: false
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
name: L-homoserine
type: Species
initial amount: NaN
is: CHEBI:15699

metaR GCCbim
reactant: MODEL1310110004#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.4.4.2
name: glycine-cleavage complex (lipoylprotein) irreversible, mitochondrial
reversible: false
is version of: http://identifiers.org/ec-code/2.1.2.10
type: Reaction
modifier: MODEL1310110004#

metaR r1612
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110004#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110004#
reversible: true

metaM HC01410 m
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:28706
name: (2E)-Hexenoyl-CoA
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
boundary condition: false
initial amount: NaN
constant: false

metaR r2331
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000

metaR r0809
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
name: Facilitated diffusion
product: MODEL1310110004#
is: SBO:0000185
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:

metaR DNDPt28m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
modifier: MODEL1310110004#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
name: dCDP transport via dGDP antiport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110004#

metaM dd2coa x
name: trans-Dodec-2-enoyl-CoA
is: SBO:0000247
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:57330
is: HMDB03712
initial concentration: 1.0
has only substance units: false

metaM glcur l
boundary condition: false
name: D-glucuronate
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
initial amount: NaN
type: Species
is: HMDB00127
initial concentration: 1.0
has only substance units: false
is: CHEBI:15748
is: SBO:0000247
constant: false

metaR NDPK4n
reversible: true
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110004#
fast: false
type: Reaction
reactant: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
product: MODEL1310110004#

metaM hexc e
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1
name: cerotate
boundary condition: false
type: Species
is: HMDB02356
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:31013
initial concentration: 1.0
has only substance units: false

metaM cdpdag hs c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:58332
boundary condition: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
is: SBO:0000247
name: CDP-diacylglycerol(2-)

metaR RE3005M
product: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
reversible: true
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000176
name: RE3005
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false

metaR r2330
is: SBO:0000185
reactant: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110004#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

http://identifiers.org/biomodels.db/MODEL1310110004#_1fe8f274_d487_4b77_9322_1516602c4b43
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:883
has only substance units: false
is: Q16773
is: SBO:0000252
initial concentration: NaN
name: CCBL1
type: Species

metaR DOLASNT Uer
is: SBO:0000176
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD
kinetic law: MODEL1310110004#
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.119
reactant: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110004#

metaM gtp c
is: CHEBI:37565
is: SBO:0000247
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial concentration: 1.0
constant: false
has only substance units: false
is: C00044
boundary condition: false
name: GTP
initial amount: NaN
is: HMDB01273
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_146027ca_c5a2_44e8_9168_6b96a55aa28c
initial concentration: NaN
type: Species
name: ACOX1
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: B4DK61
is encoded by: hsa:51

metaR r1611
reversible: true
reactant: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185

metaM ksii core4 pre9 g
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:28067
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 9
type: Species
has only substance units: false

metaM 2docopencoa x
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
type: Species
name: 2,7,10,13,16-docosapentenoylcoa
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
boundary condition: false

metaM fe3 c
name: Fe3+
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB12943
constant: false
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: Fe CHARGE: 3

metaM val L c
initial concentration: 1.0
is: HMDB00883
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:16414
is: SBO:0000247
name: L-valine
type: Species

metaR RE2349C
is version of: http://identifiers.org/ec-code/2.6.1.64
fast: false
name: RE2349
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
reactant: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#

metaR DURIt
fast: false
name: deoxyuridine transport via diffusion
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true

metaM tetpent3 c
boundary condition: false
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: HMDB06323
is: SBO:0000247
name: tetracosapentaenoic acid, n-3
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species

metaR C6CRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexanoyl carnitine into the extra cellular fluid
type: Reaction

metaR S6TASE21ly
type: Reaction
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
product: MODEL1310110004#
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_0bf04435_4d9c_444f_a2ed_2ae1693c3f4a
initial concentration: NaN
constant: false
is: SBO:0000252
is: P39656
has only substance units: false
boundary condition: true
is encoded by: hsa:1650
initial amount: NaN
type: Species
name: DDOST

metaR ACALDtm
fast: false
kinetic law: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
name: acetaldehyde mitochondrial diffusion
is described by: ECO:0000000
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
is: SBO:0000185
reversible: true

metaR FAOXC204C205x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

metaR KCCt
modifier: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
reactant: MODEL1310110004#
name: K+-Cl- cotransport
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110004#
reversible: true

metaM arachdcrn m
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: C20:4 carnitine
initial concentration: 1.0
is: CHEBI:57387
type: Species
is: HMDB01322
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
has only substance units: false
constant: false

metaR B3GNT32g
reactant: MODEL1310110004#
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
is described by: ECO:0000269
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110004#

metaM HC00250 c
is: CHEBI:29919
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: hydrosulfide
type: Species
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial amount: NaN
is: SBO:0000247
constant: false

metaR r2333
reactant: MODEL1310110004#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_435f60e2_7b88_4e0a_a75b_ac53a3b895f3
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR r1610
product: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110004#
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_5d364d0c_dd14_4337_abb9_17a3d059f616
is: SBO:0000252
is: P31040
boundary condition: true
name: SDHA
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:6389
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_124e8e2a_6fcc_48f2_bbaf_796c0754d367
is: SBO:0000252
name: GCNT2
initial amount: NaN
has only substance units: false
is: Q08M29
is encoded by: hsa:2651
initial concentration: NaN
type: Species
boundary condition: true
constant: false

metaM f1a l
initial amount: NaN
is: CHEBI:17151
is: SBO:0000247
name: F1alpha
has only substance units: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: HMDB02917

metaR CYTDK1
fast: false
modifier: MODEL1310110004#
is: SBO:0000176
reversible: false
name: ATPcytidine 5-phosphotransferase
kinetic law: MODEL1310110004#
is described by: ECO:0000254
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.1.48
product: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR SUBERCACT
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_9b305b6c_5b3e_4210_8417_a8c44d588327
type: Species
name: SCD5
constant: false
boundary condition: true
is: Q86SK9
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:79966
initial amount: NaN

metaM hexc c
name: cerotate
boundary condition: false
type: Species
is: HMDB02356
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:31013
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C26H51O2 CHARGE: -1 INCHI: InChI=1S/C26H52O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26(27)28/h2-25H2,1H3,(H,27,28)/p-1

http://identifiers.org/biomodels.db/MODEL1310110004#_56175cf7_1c6a_4771_8b8a_b8ba5e7cc6d8
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is: Q9H999
type: Species
is encoded by: hsa:79646
name: PANK3
boundary condition: true
initial amount: NaN

metaM lys L m
initial amount: NaN
has only substance units: false
is: CHEBI:32551
name: L-lysinium(1+)
constant: false
is: SBO:0000247
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
initial concentration: 1.0
type: Species
boundary condition: false

metaM gtp e
is: CHEBI:37565
constant: false
initial concentration: 1.0
name: GTP(4-)
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01273
type: Species
is: SBO:0000247

metaR r2332
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110004#_7e308657_47a9_47fe_b835_3c873923ebc4
is: SBO:0000252
boundary condition: true
name: ATP5J
type: Species
is: Q6IB54
is encoded by: hsa:522
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR PPA
reversible: false
is described by: ECO:0000269
is: SBO:0000176
name: inorganic diphosphatase
is version of: http://identifiers.org/ec-code/3.6.1.1
fast: false
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
kinetic law: MODEL1310110004#
product: MODEL1310110004#
modifier: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction

metaR FAOXC103C102x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)x
type: Reaction

metaM 2decdicoa m
initial amount: NaN
type: Species
name: 2,7-decadienoylcoa
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
constant: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaR ACACT7p
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
reversible: false
reactant: MODEL1310110004#
is described by: ECO:0000269
modifier: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
is: SBO:0000176
kinetic law: MODEL1310110004#

metaR MI1PS
kinetic law: MODEL1310110004#
name: myo-Inositol-1-phosphate synthase
product: MODEL1310110004#
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
reactant: MODEL1310110004#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.5.1.4
modifier: MODEL1310110004#
reversible: false

metaR UGALNACtg
is described by: ECO:0000269
kinetic law: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
name: UDP-GalNAc Golgi transport via CMP antiport
modifier: MODEL1310110004#
reversible: true
is: SBO:0000185

metaM val L e
boundary condition: false
is: HMDB00883
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:16414
has only substance units: false
name: L-valine
is: SBO:0000247

metaR r1616
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110004#
reversible: true
fast: false
is described by: ECO:0000000
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR FAOXC164C163x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

metaM tridcoa m
notes: FORMULA: C34H56N7O17P3S CHARGE: -4
name: tridecanoylcoa
type: Species
has only substance units: false
initial amount: NaN
is: HMDB13109
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_3a951379_50a8_40fb_a56c_2fc626427279
initial concentration: NaN
is: Q96GD0
boundary condition: true
name: PDXP
is encoded by: hsa:57026
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaM C02470 e
constant: false
is: http://identifiers.org/pubchem.compound/5485
has only substance units: false
initial amount: NaN
is: C02470
is: HMDB00881
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: Xanthurenic acid
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470

http://identifiers.org/biomodels.db/MODEL1310110004#_e27b827c_6de3_41ae_a9d0_981c5c852db6
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
name: MGAM
initial concentration: NaN
is: O43451
constant: false
type: Species
is encoded by: hsa:8972

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaM pail5p hs c
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
constant: false
is: CHEBI:57795
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR LNLNCACRNt
modifier: MODEL1310110004#
is: SBO:0000185
name: transport into the mitochondria (carnitine)
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
reactant: MODEL1310110004#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_d8e33200_01b8_4a32_9306_9bf9eb4bd779
initial amount: NaN
has only substance units: false
is encoded by: hsa:54963
type: Species
boundary condition: true
is: SBO:0000252
is: Q53HM1
name: UCKL1
initial concentration: NaN
constant: false

metaR FACOAL245 1
name: fatty-acid--CoA ligase
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110004#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#

metaR DCSPTN1t
kinetic law: MODEL1310110004#
name: fatty acid transport via diffusion
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR GTHRDt
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
type: Reaction
reversible: true
product: MODEL1310110004#
name: Glutathione transport into mitochondria

metaR r1615
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR RE2445E
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (1636.1) or (59272.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.15.1 Confidence Level: 0 AUTHORS: PMID:11244003 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.4.17.23
name: RE2445
is version of: http://identifiers.org/ec-code/3.4.15.1

metaM 3ttetddcoa c
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
initial concentration: 1.0
type: Species
name: 3-hydroxy trans5,8tetradecadienoyl coa
is: SBO:0000247
initial amount: NaN
is: HMDB02014
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_42ab02e0_0acc_4727_9f67_220c4f6dc516
initial concentration: NaN
is encoded by: hsa:6470
constant: false
is: SBO:0000252
has only substance units: false
type: Species
name: SHMT1
initial amount: NaN
boundary condition: true

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR APOC LYS BTNP
type: Reaction
name: proteolysis of apoC-Lys-btn
is: SBO:0000176
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is described by: ECO:0000000
product: MODEL1310110004#
fast: false
reactant: MODEL1310110004#

metaR r2334
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reversible: true
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_galacglcgal14acglcgalgluside_hs_g
has only substance units: false
name: i-antigen
is: SBO:0000247
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:26174

metaR DHEAtr
fast: false
reactant: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
name: Dehydroepiandrosterone transport
product: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:
reversible: true

metaR FACOAL245 2
kinetic law: MODEL1310110004#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110004#
product: MODEL1310110004#
reversible: true
fast: false
type: Reaction

metaR FAOXC123x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)x
type: Reaction

metaM adpcoa x
type: Species
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: HMDB04047
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: C14143
name: adipoylcoa

metaR r1614
type: Reaction
reversible: true
reactant: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110004#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110004#_eee883cb_9571_4404_8aa5_d52ca4bd5b8f
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: G6PC3
initial concentration: NaN
is: Q9BUM1
is encoded by: hsa:92579
type: Species
boundary condition: true

metaM glcur e
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
constant: false
is: HMDB00127
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
name: D-glucuronate

http://identifiers.org/biomodels.db/MODEL1310110004#_ebc6d4f8_3806_4677_8b1d_9b3f84418870
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: _AA419122_1_c
type: Species
is encoded by: hsa:AA419122

metaM C02470 c
is: http://identifiers.org/pubchem.compound/5485
constant: false
is: C02470
initial amount: NaN
is: HMDB00881
type: Species
boundary condition: false
name: Xanthurenic acid
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM glyald m
type: Species
is: SBO:0000247
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: CHEBI:17378
boundary condition: false
name: D-glyceraldehyde
has only substance units: false
initial amount: NaN
constant: false
is: HMDB01051
initial concentration: 1.0

metaM hom L c
type: Species
is: CHEBI:15699
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
name: L-homoserine
is: HMDB00719
boundary condition: false
constant: false
initial amount: NaN

metaR S6T17g
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110004#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000176
product: MODEL1310110004#
modifier: MODEL1310110004#

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_5de8dc81_b68d_4b26_9998_982154a7f683
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:4524
initial concentration: NaN
name: MTHFR
is: Q59GJ6
has only substance units: false
type: Species
boundary condition: true

metaR CHAT
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
type: Reaction
modifier: MODEL1310110004#
is described by: ECO:0000269
reversible: true
name: Choline O-acetyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.6
is: SBO:0000176
fast: false
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_132b896e_d471_4acb_a522_72eae88e05d6
is: Q02252
has only substance units: false
constant: false
boundary condition: true
name: ALDH6A1
is encoded by: hsa:4329
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252

metaR r1613
kinetic law: MODEL1310110004#
product: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110004#
fast: false

metaM C02528 r
initial concentration: 1.0
type: Species
constant: false
name: chenodeoxycholate
initial amount: NaN
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
has only substance units: false
is: HMDB00518
boundary condition: false
is: SBO:0000247
is: CHEBI:36234

metaM HC01444 e
has only substance units: false
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
name: Galactosylglycerol
is: CHEBI:15754
boundary condition: false
initial concentration: 1.0

metaM o2 x
is: CHEBI:15379
constant: false
has only substance units: false
is: HMDB01377
initial amount: NaN
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
name: O2

http://identifiers.org/biomodels.db/MODEL1310110004#_b6120c95_116d_462e_a00b_df10c2bbc72a
is: SBO:0000252
is: Q8IWU9
type: Species
initial concentration: NaN
is encoded by: hsa:121278
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: TPH2

metaR LTC4Sr
reactant: MODEL1310110004#
reversible: false
name: Leukotriene C4 synthase
notes: GENE_ASSOCIATION: (4056.1) or (4259.1) or (4056.2) or (4258.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 4.4.1.20 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:previous EC 2.5.1.37 EC: 4.4.1.20 NJ
is version of: http://identifiers.org/ec-code/2.5.1.18
type: Reaction
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/4.4.1.20
kinetic law: MODEL1310110004#
fast: false
product: MODEL1310110004#
is described by: ECO:0000269
is: SBO:0000176

metaM fe3 e
initial amount: NaN
name: Fe3+
notes: FORMULA: Fe CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC01847
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB12943
is: SBO:0000247
is: CHEBI:29034
constant: false
type: Species

metaM strch2 e
is: SBO:0000247
notes: FORMULA: C18H32O16 CHARGE: 0
constant: false
is: HMDB00122
initial amount: NaN
has only substance units: false
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
is: CHEBI:4167
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_38c66673_a6f3_4a3a_b5c1_a4b38cc6b3f8
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3037
constant: false
is: Q92819
initial amount: NaN
name: HAS2
is: SBO:0000252

metaM ksi pre27 g
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C00130
is: CHEBI:58053
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
initial concentration: 1.0
type: Species
constant: false
name: keratan sulfate I biosynthesis, precursor 27
boundary condition: false
is: HMDB00175

metaM 3ddcrn e
constant: false
boundary condition: false
name: 3-hydroxydodecanoylcarnitine
initial concentration: 1.0
is: C02838
is: SBO:0000247
is: HMDB00791
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C19H37NO5 CHARGE: 0

metaR PRFGS
is version of: http://identifiers.org/ec-code/6.3.5.3
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
name: phosphoribosylformylglycinamidine synthase
fast: false
notes: GENE_ASSOCIATION: (5198.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
product: MODEL1310110004#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110004#

metaM pail3p hs c
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
is: SBO:0000247
boundary condition: false
is: CHEBI:58088
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
constant: false
initial concentration: 1.0

metaR UMPK7n
fast: false
name: UMP kinase (dGTP),nuclear
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
modifier: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110004#

metaM noncoa m
initial amount: NaN
is: C01942
constant: false
type: Species
name: nonanoylcoa
is: HMDB13028
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C30H48N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110004#_9640f189_a7ef_4e98_b703_c42041dd63ff
is: P05496
initial concentration: NaN
constant: false
is encoded by: hsa:516
name: ATP5G1
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species

metaR NAGAlby
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:Beta-galactosidase B - no evidence to support this actually happens yet; added by analogy with alpha-galactosidase B (NAGAIy) NJ
name: N-acetylgalactosaminidase, beta-
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
fast: false
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_5dc28601_a454_4af2_b1e1_de559c85bd7f
initial concentration: NaN
is encoded by: hsa:131
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: P40394
name: ADH7
type: Species
constant: false
has only substance units: false

metaM ethamp c
constant: false
boundary condition: false
is: CHEBI:58190
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00224
initial amount: NaN
name: ethamp[c]
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
type: Species

metaR r0541
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110004#
product: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
is version of: http://identifiers.org/ec-code/3.6.1.5
fast: false
reactant: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_8203ae42_165f_49a3_a508_9547ae7b064a
initial amount: NaN
constant: false
is: SBO:0000252
name: SUCLA2
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8803
is: E5KS60
boundary condition: true

metaR r2326
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110004#
is: SBO:0000185
reversible: true

metaM m7masnB g
is: C04946
notes: FORMULA: C64H107N2O50X CHARGE: 0
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_3e9433b5_b643_437f_979f_1b48645229b5
name: ATP5J2
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: Q6IBB3
has only substance units: false
is encoded by: hsa:9551

metaM vacc c
is: C08367
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
type: Species
initial amount: NaN
is: CHEBI:30828
name: trans-vaccenate

metaR r1619
reactant: MODEL1310110004#
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110004#
modifier: MODEL1310110004#

metaM gthox m
constant: false
initial concentration: 1.0
type: Species
is: HMDB03337
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: CHEBI:58297
has only substance units: false
is: SBO:0000247

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaM 2dodtricoa m
is: C05279
constant: false
type: Species
name: 2,6,9-dodecatrienoylcoa
is: HMDB11123
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_d07606a1_129b_4512_b007_a34de0598900
initial concentration: NaN
name: SI
is: P14410
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6476

http://identifiers.org/biomodels.db/MODEL1310110004#_64103efb_2bb2_43e8_a21c_86d01754d36f
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: D9HTE9
boundary condition: true
type: Species
is encoded by: hsa:6576
has only substance units: false
name: SLC25A1
constant: false

metaM oh1 c
name: hydroxide ion
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
type: Species
is: C01328
notes: FORMULA: HO CHARGE: -1
is: HMDB01039

metaR r0954
reversible: true
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
fast: false
is: SBO:0000185
name: MCT 1 Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17180682 NOTES:
type: Reaction

metaM 34dhmald c
name: 3,4-Dihydroxymandelaldehyde
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: http://identifiers.org/pubchem.compound/7903
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C05577
constant: false
is: HMDB06242
type: Species

metaR DDECCRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_44548446_7025_49e0_ae0a_313c68b697a4
is encoded by: hsa:4645
initial concentration: NaN
name: MYO5B
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q9H6Y6
constant: false
is: SBO:0000252
type: Species

metaR r0653
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reversible: false
type: Reaction
product: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR r2327
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_2085d618_69ea_48cd_9941_2d58f204c46f
has only substance units: false
name: _D29675_1_c
type: Species
is encoded by: hsa:D29675
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false

metaR FRUt4
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
modifier: MODEL1310110004#
fast: false
name: D-fructose transport via sodium cotransport
kinetic law: MODEL1310110004#
type: Reaction
reversible: true
is: SBO:0000185

metaM thmmp m
notes: FORMULA: C12H16N4O4PS CHARGE: -1 INCHI: InChI=1S/C12H17N4O4PS/c1-8-11(3-4-20-21(17,18)19)22-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H3-,13,14,15,17,18,19)/p-1 EHMN_ABBREVIATION: C01081
initial amount: NaN
has only substance units: false
name: thiamine(1+) monophosphate(2-)
initial concentration: 1.0
is: CHEBI:37575
is: SBO:0000247
is: HMDB02666
boundary condition: false
constant: false
type: Species

metaR H2O2t
is: SBO:0000185
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
product: MODEL1310110004#
fast: false
name: hydrogen peroxide transport via diffusion
reactant: MODEL1310110004#
reversible: true
is described by: ECO:0000000
type: Reaction

metaM 3hexdcoa c
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
boundary condition: false
initial amount: NaN
name: 3-hydroxyhexadecanoylcoa
has only substance units: false
is: SBO:0000247
is: HMDB03932
type: Species
is: C05258
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_129dee70_2249_482a_8102_f27ffae5c77c
is: P27707
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
name: DCK
initial concentration: NaN
is encoded by: hsa:1633

http://identifiers.org/biomodels.db/MODEL1310110004#_8dd35a2e_f6cc_4b5e_b4d2_ee74b08ec8a9
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
name: _AI222095_1_e
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:AI222095

http://identifiers.org/biomodels.db/MODEL1310110004#_f9e6248e_6769_4a18_8f3e_9df9467f1bb0
is: P50213
name: IDH3A
is encoded by: hsa:3419
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
type: Species

metaR r1617
reversible: true
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
modifier: MODEL1310110004#
is: SBO:0000185
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_f09b6c3f_b5dd_4569_b8d4_b4fc8a802d43
boundary condition: true
has only substance units: false
is encoded by: hsa:5152
is: SBO:0000252
constant: false
initial concentration: NaN
name: PDE9A
initial amount: NaN
type: Species

metaR r2328
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110004#

metaM vacc e
is: CHEBI:30828
type: Species
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/p-1/b8-7+
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
name: trans-vaccenate

metaR r0656
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
kinetic law: MODEL1310110004#
product: MODEL1310110004#
name: 3-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(3-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110004#
reversible: false

metaR TRPO2
is: SBO:0000176
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110004#
fast: false
modifier: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (6999.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.13.11.11 Confidence Level: 4 AUTHORS: PMID:8666386 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.13.11.11
name: L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

metaR DTTPtn
product: MODEL1310110004#
name: dTTP diffusion in nucleus
kinetic law: MODEL1310110004#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
reactant: MODEL1310110004#
reversible: true
is described by: ECO:0000000

metaM gtp n
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP(4-)
initial concentration: 1.0
is: CHEBI:37565
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01273

http://identifiers.org/biomodels.db/MODEL1310110004#_316d0ce8_5c84_4023_bf20_6531f4a32c6a
initial amount: NaN
is encoded by: hsa:2348
type: Species
constant: false
initial concentration: NaN
has only substance units: false
name: FOLR1
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_d056da00_04ed_4771_a67c_2f8e43d06960
is: Q9UI40
type: Species
initial concentration: NaN
boundary condition: true
name: SLC24A2
has only substance units: false
is encoded by: hsa:25769
constant: false
initial amount: NaN
is: SBO:0000252

metaM phytcoa x
initial concentration: 1.0
is: SBO:0000247
name: phytanoyl-CoA(4-)
constant: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-26(2)11-8-12-27(3)13-9-14-28(4)15-10-16-29(5)21-32(50)69-20-19-43-31(49)17-18-44-39(53)36(52)41(6,7)23-62-68(59,60)65-67(57,58)61-22-30-35(64-66(54,55)56)34(51)40(63-30)48-25-47-33-37(42)45-24-46-38(33)48/h24-30,34-36,40,51-52H,8-23H2,1-7H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/t27?,28?,29?,30-,34-,35-,36+,40-/m1/s1
boundary condition: false
has only substance units: false
is: CHEBI:57391
type: Species
initial amount: NaN
is: HMDB01359

metaM glcur r
name: D-glucuronate
boundary condition: false
constant: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127
is: SBO:0000247
initial amount: NaN
is: CHEBI:15748
has only substance units: false
type: Species
initial concentration: 1.0

metaR DM fol
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaR NH4t3r
is described by: ECO:0000269
reactant: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
fast: false
type: Reaction
name: ammonia transport via proton antiport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110004#_0e252e50_a927_48b9_9a26_1bf0722c8a5b
boundary condition: true
initial amount: NaN
initial concentration: NaN
has part: E9PB82
name: ACAA1:HSD17B4:ACOX1
is encoded by: hsa:3295
has only substance units: false
constant: false
is: SBO:0000297
type: Species

metaR FAOXC181C181OHm
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C18:1OH)m
type: Reaction

metaR r0655
reversible: true
kinetic law: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.2
modifier: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110004#
fast: false
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10

metaM 4hglusa m
name: L-4-hydroxyglutamic semialdehyde
is: HMDB06556
is: CHEBI:27809
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
constant: false
boundary condition: false

metaR SIAASE3ly
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: sialidase, lysosomal
reversible: false
is described by: ECO:0000000
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
kinetic law: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110004#

metaR r1618
type: Reaction
is: SBO:0000185
product: MODEL1310110004#
is described by: ECO:0000000
modifier: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM C04849 e
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
is: CHEBI:57449
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849

metaR r2329
fast: false
kinetic law: MODEL1310110004#
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reversible: true

metaM oh1 e
type: Species
is: HMDB01039
is: C01328
initial amount: NaN
notes: FORMULA: HO CHARGE: -1
name: hydroxide ion
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false

metaR HPACtr
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110004#
name: hydroxyphenylacetate transport via diffusion
product: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_3247d33d_8dca_45f3_9946_09021c859080
type: Species
initial amount: NaN
is: P30566
is encoded by: hsa:158
constant: false
has only substance units: false
boundary condition: true
name: ADSL
initial concentration: NaN
is: SBO:0000252

metaR PHCDm
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
is version of: http://identifiers.org/ec-code/1.5.1.12
kinetic law: MODEL1310110004#
is described by: ECO:0000304
is: SBO:0000176
product: MODEL1310110004#
fast: false
modifier: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110004#_dafcf760_317a_4325_bb0f_dfd8874a94fa
has only substance units: false
initial amount: NaN
is: E9KL44
boundary condition: true
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
name: HADHA
is encoded by: hsa:3030

metaM gtp m
name: GTP
type: Species
constant: false
is: HMDB01273
is: C00044
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:37565
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_c92aa63a_2b63_481d_af14_d676e629ba16
boundary condition: true
is: SBO:0000252
name: RRM2B
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: Q7LG56
is encoded by: hsa:50484

metaR OCT11EFATP
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_e07307cb_1ce4_4523_a939_058284013466
boundary condition: true
type: Species
initial concentration: NaN
name: HK1
has only substance units: false
is encoded by: hsa:3098
is: SBO:0000252
is: P78542
initial amount: NaN
constant: false

metaM chito2pdol U c
boundary condition: false
type: Species
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:12427
constant: false

metaR ACACT10m
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
fast: false
product: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
is described by: ECO:0000134
reactant: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
type: Reaction
name: acetyl-CoA C-acetyltransferase, mitochondrial
kinetic law: MODEL1310110004#

metaM cholcoa x
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
name: choloyl-CoA(4-)
is: CHEBI:57373
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB01374
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_eb846bcf_8f84_4f4a_b63e_4433b4585786
initial amount: NaN
name: NDUFA12
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:55967
has only substance units: false
is: F8VQS7
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_1bf87f06_027e_4aab_9e06_87539433d6a5
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is: B2ZGL7
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:11343
name: MGLL
type: Species

metaM CE5788 e
initial concentration: 1.0
is: HMDB02710
is: CHEBI:27485
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
type: Species
name: kinetensin 1-7

http://identifiers.org/biomodels.db/MODEL1310110004#_ec290f9a_4f47_4236_b18e_06bfc11510b4
is encoded by: hsa:23657
has part: Q9UPY5
name: SLC7A11:SLC3A2
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000297
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_a04c0624_8e36_425f_90d9_18ba06af2426
is: P37268
type: Species
initial concentration: NaN
is encoded by: hsa:2222
has only substance units: false
initial amount: NaN
name: FDFT1
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_9757b8f0_fdba_40bd_801b_d66f562ea2cb
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:7001
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is: P32119
has only substance units: false
name: PRDX2

metaR AHCYSte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110004#
is described by: ECO:0000134
product: MODEL1310110004#
reversible: true
name: Transport of S-adenosyl-L-homocysteine
fast: false
kinetic law: MODEL1310110004#

metaM dtdp m
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:58369
constant: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
name: dTDP
initial concentration: 1.0
type: Species
is: C00363
is: HMDB01274

metaR CHOLATEt
reversible: true
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
modifier: MODEL1310110004#
fast: false
name: cholate transport via bicarbonate countertransport
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110004#
kinetic law: MODEL1310110004#

metaR RE1903R
name: RE1903
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
reactant: MODEL1310110004#
fast: false
is: SBO:0000176
product: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_a1b6b3b3_6871_4af5_ab0d_7affd446a79b
is: SBO:0000252
type: Species
has only substance units: false
is: Q9NR34
name: MAN1C1
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:57134
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_304bceea_aa20_4a52_8a01_b76386ef2018
is encoded by: hsa:AA203143
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: _AA203143_1_c
boundary condition: true
is: SBO:0000252

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_429c71c6_51de_4d77_ad76_8821381947ee
is encoded by: hsa:AA629629
type: Species
name: _AA629629_1_m
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true

metaR FAOXC226C225x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)x
type: Reaction

metaR DINt
type: Reaction
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reactant: MODEL1310110004#
fast: false
reversible: true
is described by: ECO:0000000
name: deoxyinosine transport via diffusion

metaM dtdp n
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
constant: false
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
type: Species
is: HMDB01274
is: CHEBI:58369
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_6c75b178_436a_4a50_83cb_73fbf376ab8c
is encoded by: hsa:2618
initial amount: NaN
name: GART
type: Species
is: Q59HH3
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR KAS8
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110004#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110004#
name: b-ketoacyl synthetase (palmitate, n-C16:0)
product: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110004#_4ba82832_663a_43e3_af56_cda6fb6e3bd8
is: SBO:0000252
is encoded by: hsa:51703
constant: false
is: Q9ULC5
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
name: ACSL5

http://identifiers.org/biomodels.db/MODEL1310110004#_ebc75ff9_cc75_40bb_9db3_f79ee55d6d5f
is encoded by: hsa:51179
boundary condition: true
name: HAO2
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q9NYQ3

metaR C4CRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaM glac c
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
type: Species
initial amount: NaN
name: D-glucurono-6,3-lactone
is: SBO:0000247
is: HMDB06355
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:18268

http://identifiers.org/biomodels.db/MODEL1310110004#_15d54ed6_eb27_4192_9811_92e6579d37c3
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:AA177072
name: _AA177072_1_c
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN

metaR RETNt
fast: false
reversible: true
name: retinoic acid transport
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#

metaM 3ddcrn c
boundary condition: false
initial amount: NaN
type: Species
name: 3-hydroxydodecanoylcarnitine
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00623
notes: FORMULA: C19H37NO5 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110004#_9e467716_b176_4b78_a667_a9b45c8fa889
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
name: DGAT2
is: Q96PD7
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:84649

http://identifiers.org/biomodels.db/MODEL1310110004#_ed5d6667_b3a5_4a60_a6b9_536c5fa87b9b
is encoded by: hsa:6240
has only substance units: false
has part: P31350
name: RRM1:RRM2
has part: P23921
constant: false
type: Species
is: SBO:0000297
boundary condition: true
initial amount: NaN
is encoded by: hsa:6241
initial concentration: NaN

metaM dutp c
initial concentration: 1.0
type: Species
is: CHEBI:17625
is: SBO:0000247
boundary condition: false
is: C00460
initial amount: NaN
name: dUTP
is: HMDB01191
constant: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
has only substance units: false

metaR It
is: SBO:0000185
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
kinetic law: MODEL1310110004#
fast: false
name: Iodide uniport
reversible: true
modifier: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
is described by: ECO:0000269

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_8d99c428_e176_48e4_9d3a_e81e3e2bb0bd
initial amount: NaN
is encoded by: hsa:26275
name: HIBCH
is: Q6NVY1
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR NDPK9n
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
product: MODEL1310110004#
is described by: ECO:0000269
modifier: MODEL1310110004#
is: SBO:0000176
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_641fcdc0_f54f_4910_b243_ec12ade0732f
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:27068
name: PPA2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_fcbc130b_f141_4de8_8075_233ddb73cb7b
is encoded by: hsa:114134
initial concentration: NaN
has only substance units: false
is: Q96QE2
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: SLC2A13
is: SBO:0000252

metaR AHCYStd
kinetic law: MODEL1310110004#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
name: diffusion of S-Adenosyl-L-homocysteine

metaR PSSA2 hs
fast: false
name: Phosphatidylserine synthase homo sapiens
type: Reaction
kinetic law: MODEL1310110004#
reversible: true
product: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.8.29
modifier: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ
is: SBO:0000176

metaM ksi deg29 l
is: CHEBI:12936
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C96H157N6O80S3 CHARGE: -3
initial amount: NaN
type: Species
has only substance units: false
is: HMDB00143
name: keratan sulfate I, degradation product 29

metaR r0549
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is version of: http://identifiers.org/ec-code/1.6.99.3
type: Reaction
fast: false
product: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.6.5.3
is version of: http://identifiers.org/ec-code/6.1.1.17
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:

metaR RE3421R
reversible: true
name: RE3421
reactant: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
kinetic law: MODEL1310110004#
fast: false
is described by: ECO:0000000
product: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_71028fef_3142_4e93_bea8_98ab238789fa
constant: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:4729
has only substance units: false
initial concentration: NaN
is: P19404
is: SBO:0000252
name: NDUFV2

metaR r1318
is described by: ECO:0000000
name: Transport reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
fast: false

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaM Lfmkynr c
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C11H12N2O4 CHARGE: 0 INCHI: InChI=1S/C11H12N2O4/c12-8(11(16)17)5-10(15)7-3-1-2-4-9(7)13-6-14/h1-4,6,8H,5,12H2,(H,13,14)(H,16,17)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00985 EHMN_ABBREVIATION: C02700
constant: false
is: HMDB01200
is: CHEBI:30249
name: N-formyl-L-kynurenine
initial amount: NaN

metaR GGT6
kinetic law: MODEL1310110004#
product: MODEL1310110004#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110004#
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene E4 (LTE4) to leukotriene D4 (LTE4). NJ
name: Gamma-glutamyltransferase

metaR GPIMTer L
modifier: MODEL1310110004#
reversible: false
is described by: ECO:0000000
name: GlcN-acylPI mannosyltransferase, endoplasmic reticulum
is: SBO:0000176
fast: false
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (93183.1) and (54965.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11226175,PMID:15635094 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110004#_19e0acea_cf75_42cf_add7_e2868ec7d389
initial amount: NaN
constant: false
initial concentration: NaN
is: C9JFZ1
is encoded by: hsa:8867
type: Species
name: SYNJ1
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR G6PDH2rer
is version of: http://identifiers.org/ec-code/1.1.1.47
reversible: true
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
is: SBO:0000176
fast: false
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#

metaR NTD8
reversible: false
notes: GENE_ASSOCIATION: (22978.1) or (30833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
name: 5'-nucleotidase (dGMP)
is described by: ECO:0000269
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000176
modifier: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
type: Reaction

metaM galgalthcrm hs g
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C48H86NO27FULLRCO CHARGE: 0
constant: false
name: Gal-Gal-Gal-Gal-Glc-Cer
initial concentration: 1.0
is: CHEBI:26174
has only substance units: false
initial amount: NaN

metaM ei11ecoa x
type: Species
initial concentration: 1.0
notes: FORMULA: C41H68N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
has only substance units: false
constant: false
name: 11-eicosenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110004#_34c70c45_9073_4cfd_8110_eeb748b97444
type: Species
has only substance units: false
is encoded by: hsa:53354
boundary condition: true
constant: false
name: PANK1
initial concentration: NaN
initial amount: NaN
is: Q8TE04
is: SBO:0000252

metaM CE2435 m
is: CHEBI:57795
constant: false
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
name: trans,cis-deca-2,4-dienoyl-CoA
has only substance units: false

metaM cholate c
name: Cholate
is: CHEBI:29747
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00619
constant: false

metaM c226coa c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205479
is: C16169
has only substance units: false
boundary condition: false
name: cervonyl coenzyme A
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
constant: false
type: Species
initial amount: NaN

metaM glyald c
name: D-Glyceraldehyde
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
boundary condition: false
type: Species
is: CHEBI:17378
constant: false
is: SBO:0000247
initial amount: NaN
is: C00577
has only substance units: false
is: HMDB01051
initial concentration: 1.0

metaR GGH 7THFe
reactant: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
modifier: MODEL1310110004#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (7THF), extracellular
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
kinetic law: MODEL1310110004#

metaR M7MASNBterg
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
reactant: MODEL1310110004#
is: SBO:0000185
kinetic law: MODEL1310110004#
is described by: ECO:0000000
product: MODEL1310110004#
fast: false
reversible: false
name: m7masnB transport from endoplasmic reticulum to Golgi apparatus
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_73c69f9a_668d_40b0_bef9_66b0f46718a7
name: PYCR2
is: SBO:0000252
initial concentration: NaN
is: Q96C36
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:29920
constant: false
type: Species

metaR q10h2tc
is: SBO:0000185
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
name: transport of ubiquinol into cytosol
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction

metaM hexccoa c
name: Hexacosanoyl-CoA (n-C26:0CoA)
notes: FORMULA: C47H82N7O17P3S CHARGE: -4 INCHI: InChI=1/C47H86N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-38(56)75-31-30-49-37(55)28-29-50-45(59)42(58)47(2,3)33-68-74(65,66)71-73(63,64)67-32-36-41(70-72(60,61)62)40(57)46(69-36)54-35-53-39-43(48)51-34-52-44(39)54/h34-36,40-42,46,57-58H,4-33H2,1-3H3,(H,49,55)(H,50,59)(H,63,64)(H,65,66)(H2,48,51,52)(H2,60,61,62)/p-4/t36-,40-,41-,42+,46-/m1/s1
constant: false
type: Species
has only substance units: false
boundary condition: false
is: HMDB06459
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_c0ade13c_dcdb_4b58_862e_ea58b739c6f4
name: PYCR1
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: P32322
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:5831

metaM Tn antigen l
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C8H14NO5X CHARGE: 0
name: Tn antigen
is: C04383
type: Species

metaR B3GALT3g
is described by: ECO:0000269
reversible: false
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.79
fast: false
name: Beta-1,3-galactosyltransferase 3
modifier: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#

metaM ksi deg26 l
constant: false
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
boundary condition: false
name: keratan sulfate I, degradation product 26
is: HMDB00061
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58343
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_f2a0c617_2e5f_4fd4_8b7a_a9cfe25701df
is encoded by: hsa:5049
is: SBO:0000297
has part: A8DPS7
type: Species
is encoded by: hsa:5050
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
name: PAFAH1B2:PAFAH1B3
has part: Q15102
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_1c64e8cb_6349_4d7d_87d7_66a5534a778c
has only substance units: false
is encoded by: hsa:6487
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: ST3GAL3

http://identifiers.org/biomodels.db/MODEL1310110004#_9e4d4d2c_05ae_433e_b6fb_3f096cdd6d1e
is: SBO:0000252
is: P30520
has only substance units: false
constant: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:159
name: ADSS

metaM thmmp c
is: SBO:0000247
notes: FORMULA: C12H16N4O4PS CHARGE: -1 EHMN_ABBREVIATION: C01081
is: CHEBI:37575
is: HMDB02666
initial amount: NaN
is: C01081
name: Thiamin monophosphate
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_6843181d_cf10_45a9_8889_fd0f8f758583
initial concentration: NaN
name: NDUFA6
is: SBO:0000252
is: P56556
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:4700

metaM Rtotal e
boundary condition: false
name: R total
is: HMDB00244
is: C00255
initial amount: NaN
notes: FORMULA: CO2FULLR CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:3554
constant: false
has only substance units: false
type: Species

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_3416a93a_ee0a_4c4a_b7a1_8a68f52c5f4d
is: Q8WWX8
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:115584
name: SLC5A11

http://identifiers.org/biomodels.db/MODEL1310110004#_32446d47_d916_4df5_968e_2dbf50412de9
name: ETNK2
is encoded by: hsa:55224
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is: Q9NVF9
initial concentration: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_1f72e661_5bd9_426d_bf7f_488a918b139e
type: Species
boundary condition: true
name: UPP1
is: SBO:0000252
has only substance units: false
is: Q16831
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:7378

metaM 2dodtricoa x
constant: false
type: Species
name: 2,6,9-dodecatrienoylcoa
boundary condition: false
is: SBO:0000247
is: C05279
has only substance units: false
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
is: HMDB11123
initial concentration: 1.0
initial amount: NaN

metaR METyLATthc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_f107ae6b_8860_4464_93ca_a938264a6d61
initial amount: NaN
constant: false
name: TK2
initial concentration: NaN
is: O00142
has only substance units: false
is encoded by: hsa:7084
type: Species
is: SBO:0000252
boundary condition: true

metaM xoltetrol c
is: CHEBI:17278
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
boundary condition: false
initial concentration: 1.0
is: HMDB01231
constant: false
type: Species
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol

metaR FAOXC103C102m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_36013445_6882_4e97_8478_1e926c2d0e5c
has only substance units: false
constant: false
type: Species
name: _LOC647190_1_c
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:LOC647190
is: SBO:0000252

metaM acgbgbside hs l
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
name: beta GalNAc globoside
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:17411
is: SBO:0000247
has only substance units: false
is: HMDB00215

http://identifiers.org/biomodels.db/MODEL1310110004#_41449538_ce71_4e98_ab8c_4ffac84d2464
has only substance units: false
is: SBO:0000252
is: O75355
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: ENTPD3
initial concentration: NaN
is encoded by: hsa:956

http://identifiers.org/biomodels.db/MODEL1310110004#_21484c1a_f6e9_43c2_8f98_f55cf3aeed56
name: ACAA2
type: Species
initial amount: NaN
has only substance units: false
is: P42765
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10449

metaR NTD3
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
name: 5'-nucleotidase (dCMP)
reversible: false
reactant: MODEL1310110004#
is described by: ECO:0000269
modifier: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (93034.1) or (30833.1) or (93034.2) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
kinetic law: MODEL1310110004#
is: SBO:0000176

metaM drib c
is: HMDB03224
name: 2-deoxy-D-ribose
is: CHEBI:28816
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801

metaR r1467
is: SBO:0000185
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
name: Postulated transport reaction
reversible: true
kinetic law: MODEL1310110004#
product: MODEL1310110004#
fast: false
type: Reaction

metaM trp L e
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00929
has only substance units: false
initial amount: NaN
name: L-tryptophan
is: CHEBI:16828

metaR r0650
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/4.1.1.36
modifier: MODEL1310110004#
fast: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110004#
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7

metaR r0545
reactant: MODEL1310110004#
reversible: true
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
type: Reaction
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_da3d3203_e84a_48ac_aec7_fc0b2d0d2f47
is encoded by: hsa:515
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
name: ATP5F1
is: P24539
has only substance units: false

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_9ecbb55d_c966_4ce5_99c9_971ff99b3de8
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: ENTPD1
boundary condition: true
is encoded by: hsa:953
is: Q86VV3
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_b8cafbca_5296_422b_b337_0965b07a2f6a
initial concentration: NaN
name: _X63359_1_c
boundary condition: true
is encoded by: hsa:X63359
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_e98ab8e3_f036_4997_a90a_68f26a37fb17
name: PLA2G3
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q9NZ20
boundary condition: true
type: Species
is encoded by: hsa:50487
is: SBO:0000252

metaM m7masnB r
notes: FORMULA: C64H107N2O50X CHARGE: 0
initial amount: NaN
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: C04946
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_e513efe1_5254_4ff0_be09_ba2f00407c76
constant: false
name: ND4L
is encoded by: hsa:4539
is: Q7GXZ4
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM Rtotal c
is: SBO:0000247
is: HMDB01448
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: CO2FULLR CHARGE: -1
name: R total
is: CHEBI:16189
type: Species

metaR H2O2tn
is described by: ECO:0000000
reactant: MODEL1310110004#
fast: false
name: hydrogen peroxide nuclear transport
is: SBO:0000185
type: Reaction
product: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
kinetic law: MODEL1310110004#

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR GK1
product: MODEL1310110004#
fast: false
modifier: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: guanylate kinase (GMP:ATP)
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.4.8
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110004#_ca193ff0_d2d5_4906_9e5f_dc4791e7f234
is encoded by: hsa:100
initial concentration: NaN
constant: false
name: ADA
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is: P00813

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaM 7dhchsterol c
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
has only substance units: false
name: cholesta-5,7-dien-3beta-ol
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: HMDB00032
is: CHEBI:17759

http://identifiers.org/biomodels.db/MODEL1310110004#_2f5a370e_c53f_4bbb_ba3f_36f0a64bf4da
has only substance units: false
boundary condition: true
is encoded by: hsa:23657
initial amount: NaN
name: SLC7A11
is: Q9UPY5
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252

metaR H8TAer
is described by: ECO:0000000
product: MODEL1310110004#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110004#
fast: false
name: H8 transamidase, endoplasmic reticulum
reversible: false
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD

http://identifiers.org/biomodels.db/MODEL1310110004#_b0f83157_d484_4869_b306_c20bdbbf34c7
type: Species
is: P00390
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: GSR
initial amount: NaN
is encoded by: hsa:2936

metaM naglc2p U c
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:18278
boundary condition: false
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_4b7fe126_947e_4fa9_8e79_9e1e1226c4f2
is encoded by: hsa:93034
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: NT5C1B
has only substance units: false
constant: false
initial concentration: NaN
is: Q96P26

metaR AMETt2m
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (115286.3) or (115286.2) or (115286.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14674884 NOTES:Added by RS/TV (6/17/05)
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000269
product: MODEL1310110004#
modifier: MODEL1310110004#
name: S-Adenosyl-L-methionine reversible transport, mitochondrial
type: Reaction

metaM drib e
initial amount: NaN
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
boundary condition: false
is: HMDB03224
initial concentration: 1.0
has only substance units: false
is: CHEBI:28816
is: SBO:0000247
type: Species
name: 2-deoxy-D-ribose
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_2a5cd065_3ea8_46a9_84a5_707b9effd4fd
is: P17516
is: SBO:0000252
name: AKR1C4
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:1109

metaM dece3coa x
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
constant: false
name: 3-decenoylcoa
is: http://identifiers.org/pubchem.compound/16019966

http://identifiers.org/biomodels.db/MODEL1310110004#_94f30d3b_21a7_4606_a4a3_8ac8283a07fe
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is: Q8TF08
name: COX7B2
is encoded by: hsa:170712
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR NTD5
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.1.3.5
reversible: false
fast: false
modifier: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (30833.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:4291247 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Not clear whether it is cytosolic but enzymes in this metabolism often are
type: Reaction
name: 5'-nucleotidase (dTMP)

metaR ADK1m
is version of: http://identifiers.org/ec-code/2.7.4.3
is described by: ECO:0000269
type: Reaction
product: MODEL1310110004#
name: adenylate kinase, mitochondrial
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
modifier: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

metaR r0652
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true
type: Reaction
kinetic law: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000000

metaM trp L c
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00929
constant: false
name: L-tryptophan
initial amount: NaN
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: CHEBI:16828
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_acc40478_90d6_49f2_af3a_b65261930247
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI990637
has only substance units: false
name: _AI990637_1_x
constant: false
boundary condition: true
is: SBO:0000252

metaM Tn antigen g
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
name: Tn antigen
has only substance units: false
boundary condition: false
is: C04383
notes: FORMULA: C8H14NO5X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110004#_75179e44_901a_4bfa_bd4d_a7b4c1f29995
is encoded by: hsa:220
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: P47895
is: SBO:0000252
constant: false
name: ALDH1A3

metaM bildglcur r
is: HMDB03325
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin
is: CHEBI:58471
constant: false
boundary condition: false
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_6e8af210_7de3_4a90_bee0_5be63647c9d6
initial concentration: NaN
type: Species
is encoded by: hsa:56474
initial amount: NaN
has only substance units: false
is: Q9NRF8
is: SBO:0000252
constant: false
name: CTPS2
boundary condition: true

metaM CE2424 m
has only substance units: false
initial amount: NaN
constant: false
is: HMDB11123
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28387
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424

metaM trdox m
name: Oxidized thioredoxin
initial concentration: 1.0
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
constant: false
is: SBO:0000247
type: Species
is: CHEBI:18191
has only substance units: false
initial amount: NaN
boundary condition: false

metaR H2O2tp
name: hydrogen peroxide peroxisomal transport via diffusion
reversible: true
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
fast: false
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000

metaM cholate e
has only substance units: false
is: CHEBI:29747
constant: false
type: Species
is: HMDB00619
initial concentration: 1.0
name: Cholate
boundary condition: false
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: SBO:0000247
initial amount: NaN

metaM mgacpail hs r
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
is: HMDB00220
is: CHEBI:7896
type: Species
is: SBO:0000247
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
is: C00249
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR RE0944E
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0944
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110004#

metaR r0651
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.5.1.2
type: Reaction
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
modifier: MODEL1310110004#

metaR NTD7
type: Reaction
reactant: MODEL1310110004#
is described by: ECO:0000269
product: MODEL1310110004#
fast: false
name: 5'-nucleotidase (AMP)
kinetic law: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is version of: http://identifiers.org/ec-code/3.1.3.5
modifier: MODEL1310110004#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110004#_5bf22965_5eb0_419a_9dec_300d1ced26b4
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
name: _AW277253_1_c
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:AW277253

metaM 34dhmald m
is: C05577
boundary condition: false
has only substance units: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
constant: false
type: Species
name: 3,4-Dihydroxymandelaldehyde
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7903
initial amount: NaN
is: HMDB06242

metaR DADNt4
reactant: MODEL1310110004#
name: deoxyadenosine transport via diffusion
reversible: true
fast: false
product: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110004#

metaR LNLNCACPT1
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
reactant: MODEL1310110004#
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
name: carnitine O-palmitoyltransferase
product: MODEL1310110004#
type: Reaction

metaR MDHm
reversible: true
product: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
fast: false
reactant: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.37
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
is described by: ECO:0000134
name: malate dehydrogenase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110004#_52000457_a5ae_4265_9660_46a6b71cc407
type: Species
name: TXNRD3
constant: false
has only substance units: false
is: Q86VQ6
is encoded by: hsa:114112
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM utp c
is: C00075
has only substance units: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
name: UTP
type: Species
boundary condition: false
is: HMDB00285
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:46398
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_1f7a19e4_a9f2_4c9d_9cf0_0c554d7b8938
has only substance units: false
name: _BE966236_1_c
is encoded by: hsa:BE966236
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_6365da77_ef60_41fb_8917_d6a2820a76e6
is encoded by: hsa:3939
is: P00338
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: LDHA
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaR GCCam
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.4.4.2
product: MODEL1310110004#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.10
kinetic law: MODEL1310110004#
name: glycine-cleavage complex (lipoylprotein), mitochondrial
modifier: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD

metaM ksii core2 deg6 l
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C44H72N4O33SX CHARGE: -1
is: CHEBI:12936
name: keratan sulfate II (core 2-linked), degradation product 6
type: Species
is: HMDB00143
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_c20e710c_90d3_4595_aff8_f0b2901c406d
is encoded by: hsa:8525
initial amount: NaN
has only substance units: false
name: DGKZ
initial concentration: NaN
is: SBO:0000252
is: B7Z2M9
constant: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_7ab861cb_f1d4_416b_9442_ff5667bdc6c4
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is: P12074
has only substance units: false
boundary condition: true
is encoded by: hsa:1337
initial concentration: NaN
name: COX6A1

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaM 4mop c
is: SBO:0000247
name: 4-methyl-2-oxopentanoate
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17865
is: HMDB00695
type: Species

metaM thym e
has only substance units: false
is: SBO:0000247
is: HMDB00262
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
type: Species
is: CHEBI:17821
name: thymine

metaM psyl e
is: http://identifiers.org/pubchem.compound/97364
initial concentration: 1.0
name: psyllium
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9642006H15428700O8667414 CHARGE: 0
boundary condition: false
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_5e010128_6def_42a4_8292_d71cf08abbdc
has only substance units: false
boundary condition: true
name: CHST3
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q7LGC8
is encoded by: hsa:9469

metaM orot c
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
constant: false
is: CHEBI:30839
boundary condition: false
is: SBO:0000247
is: HMDB00226
initial amount: NaN
is: C00295
has only substance units: false
initial concentration: 1.0
name: Orotate
type: Species

metaR NDPK3n
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear

metaM strdnc c
constant: false
is: C16300
is: http://identifiers.org/pubchem.compound/47205608
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB06547
type: Species
name: stearidonic acid C18:4, n-3
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
boundary condition: false
has only substance units: false

metaM gal14acglcgalgluside hs g
constant: false
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:17103
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
name: Lactoneotetraosylceramide
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_4e286cde_246a_42be_a049_6a609e9ac886
initial concentration: NaN
constant: false
initial amount: NaN
name: COX7A2L
has only substance units: false
boundary condition: true
is encoded by: hsa:9167
is: SBO:0000252
is: Q6FGA0
type: Species

metaM tetdec2crn e
constant: false
initial concentration: 1.0
type: Species
is: HMDB05066
has only substance units: false
name: tetradecadienoyl carnitine
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C21H37NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110004#_85a1d27f_bea1_41b5_8024_225cc6e8f92d
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaM HC01405 m
initial amount: NaN
is: CHEBI:28632
constant: false
is: SBO:0000247
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
has only substance units: false
name: (S)-Hydroxyoctanoyl-CoA
type: Species
boundary condition: false
initial concentration: 1.0

metaR RE1518M
is described by: ECO:0000000
fast: false
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
name: RE1518
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reversible: true
type: Reaction

metaR SIAASEly
product: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
reversible: false
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000

metaM leuktrC4 r
is: SBO:0000247
initial concentration: 1.0
is: HMDB01198
name: leukotriene C4(2-)
boundary condition: false
constant: false
type: Species
is: CHEBI:57973
has only substance units: false
initial amount: NaN
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166

metaM arachd x
name: arachidonate
initial amount: NaN
is: CHEBI:32395
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: HMDB01043
is: SBO:0000247
has only substance units: false

metaR H2MTer U
kinetic law: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110004#
reversible: false
reactant: MODEL1310110004#
is: SBO:0000176
name: H2 mannosyltransferase, endoplasmic reticulum
modifier: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110004#_b0155cad_1bde_4b7d_bd7c_91781f770df1
is: SBO:0000252
name: HPRT1
type: Species
is: P00492
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:3251
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_7f278a85_d791_48e4_a622_6d9909274a5e
name: PDE6G
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
is: P18545
constant: false
is encoded by: hsa:5148
type: Species
initial concentration: NaN

metaR ALAt2r
reactant: MODEL1310110004#
is: SBO:0000185
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
reversible: true
is described by: ECO:0000304
fast: false
name: L-alanine reversible transport via proton symport
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110004#_618d369c_3ce4_483d_ba21_fc13977f0433
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: NDUFS6
type: Species
is: Q6IBC4
is encoded by: hsa:4726

http://identifiers.org/biomodels.db/MODEL1310110004#_47e4fb5c_5b7c_4780_b1d1_0e2fc3fea739
constant: false
is: Q8IWX5
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:130367
initial concentration: NaN
has only substance units: false
name: SGPP2

http://identifiers.org/biomodels.db/MODEL1310110004#_ee6de429_cc09_4d1a_ad3c_32df18fc703d
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4882
name: NPR2

metaM so4 l
is: CHEBI:16189
name: sulfate
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
is: HMDB01448
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059

http://identifiers.org/biomodels.db/MODEL1310110004#_c5caf20c_cee3_4d64_b55a_a11f4010901a
is: O00462
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
name: MANBA
is encoded by: hsa:4126
is: SBO:0000252
constant: false

metaR NACHEX10ly
modifier: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
reversible: false
fast: false

metaM 4mop e
has only substance units: false
name: 4-methyl-2-oxopentanoate
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0
is: HMDB00695
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
boundary condition: false
is: CHEBI:17865

http://identifiers.org/biomodels.db/MODEL1310110004#_7fb9a4b5_9124_48e8_99db_3bc06c430d26
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:29922
initial concentration: NaN
name: NME7
constant: false
type: Species
is: SBO:0000252

metaM amet m
is: HMDB01185
name: S-Adenosyl-L-methionine
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: SBO:0000247
boundary condition: false
constant: false
is: C00019
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:15414
initial amount: NaN

metaR r0517
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
reversible: true

metaM dolmanp U r
name: Dolichyl phosphate D-mannose, human uterine homolog
has only substance units: false
initial amount: NaN
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:15809
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_d54d2eb3_0042_4de3_b795_828ee2b0c48c
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: P30049
name: ATP5D
constant: false
is encoded by: hsa:513
type: Species

metaR LNLNCACPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000000
name: carnitine transferase
fast: false
reactant: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
reversible: false
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_499d66cc_d28c_43cd_ae95_262bfc99f4c3
name: NDUFB1
is encoded by: hsa:4707
constant: false
type: Species
has only substance units: false
is: O75438
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM thym c
is: HMDB00262
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C00178
name: Thymine
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: CHEBI:17821
has only substance units: false

metaM strdnc e
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
initial amount: NaN
is: C16300
has only substance units: false
is: SBO:0000247
is: HMDB06547
initial concentration: 1.0
type: Species
name: stearidonic acid C18:4, n-3
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/47205608

metaM cmpacna c
is: HMDB01176
boundary condition: false
initial concentration: 1.0
is: CHEBI:57812
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128

metaM orot e
is: SBO:0000247
is: HMDB00226
boundary condition: false
initial amount: NaN
name: orotate
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
type: Species
constant: false
is: CHEBI:30839
initial concentration: 1.0
has only substance units: false

metaM fuc L l
boundary condition: false
constant: false
is: CHEBI:18287
name: L-fucose
has only substance units: false
type: Species
is: HMDB00174
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626

metaM retinal cis 13 r
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:45487
name: 13-cis-retinal
is: HMDB06220
constant: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
boundary condition: false
initial amount: NaN
has only substance units: false

metaM ksi deg31 l
is: HMDB01354
is: SBO:0000247
name: keratan sulfate I, degradation product 31
initial concentration: 1.0
boundary condition: false
is: CHEBI:57455
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C90H148N6O72S2 CHARGE: -2
constant: false

metaM tetdec2crn c
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
is: HMDB02014
name: tetradecadienoyl carnitine
boundary condition: false
is: SBO:0000247
notes: FORMULA: C21H37NO4 CHARGE: 0
initial amount: NaN

metaM dcsptn1coa m
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: HMDB06513
is: http://identifiers.org/pubchem.compound/47205483
initial amount: NaN
constant: false
type: Species
is: C16173
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR FUT911g
product: MODEL1310110004#
is described by: ECO:0000269
name: Alpha-(1,3)-fucosyltransferase
type: Reaction
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.152
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_b8cf660d_df83_4e60_8dc8_75e2cc61f382
has part: P24539
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:522
has part: P18859
is encoded by: hsa:518
boundary condition: true
constant: false
has part: O75947
type: Species
is encoded by: hsa:515
is encoded by: hsa:10476
is: SBO:0000297
has only substance units: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_f0240dc4_3392_4d3d_a51f_5a767474e6c7
constant: false
is encoded by: hsa:195814
is: SBO:0000252
has only substance units: false
boundary condition: true
is: B3KT84
initial concentration: NaN
name: SDR16C5
type: Species
initial amount: NaN

metaR r2519
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
name: Utilized transport
kinetic law: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:

metaM ala D c
has only substance units: false
name: D-alanine
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: HMDB01310
is: SBO:0000247
initial amount: NaN
is: CHEBI:15570
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_7be61e74_e608_45b1_8a01_b2aebc8e113d
is: SBO:0000252
initial amount: NaN
name: BLVRB
is: P30043
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:645
boundary condition: true
has only substance units: false

metaM 13dpg c
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
constant: false
name: 3-Phospho-D-glyceroyl phosphate
type: Species
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3535
initial concentration: 1.0
is: HMDB01270
has only substance units: false
is: SBO:0000247
is: C00236
boundary condition: false
is: CHEBI:57604

http://identifiers.org/biomodels.db/MODEL1310110004#_3c7eb1fd_3ce5_40b1_b5cf_f4cefd0a3642
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: ACADS
is: SBO:0000252
is: P16219
boundary condition: true
is encoded by: hsa:35

metaM 34hpp c
initial amount: NaN
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00707
constant: false
is: CHEBI:36242
name: 3-(4-hydroxyphenyl)pyruvate
is: SBO:0000247

metaM aps c
is: SBO:0000247
boundary condition: false
constant: false
name: 5'-adenylyl sulfate(2-)
type: Species
is: CHEBI:58243
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
is: HMDB01003
initial amount: NaN

metaR EX strch1 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
type: Reaction

metaM arachd r
type: Species
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: HMDB01043
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:32395
has only substance units: false
initial amount: NaN
name: arachidonate
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_19d96888_ac04_4604_924d_dcea5c00b5bc
is: Q15849
has only substance units: false
type: Species
is encoded by: hsa:8170
boundary condition: true
is: SBO:0000252
name: SLC14A2
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_25414f9d_9ee9_472d_b23b_4a0d56371020
type: Species
is: P48736
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: PIK3CG
initial amount: NaN
is encoded by: hsa:5294

http://identifiers.org/biomodels.db/MODEL1310110004#_7d1aab14_9127_48f6_9acb_04c0b4d1f7c3
is encoded by: hsa:3418
boundary condition: true
constant: false
name: IDH2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: P48735

metaR ALAt4
product: MODEL1310110004#
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (54407.1) or (6542.1) or (11254.1) or (6541.1) or (81539.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:tv Mendz pg. 201 Reversibility is unclear.
type: Reaction
name: Alanine-Sodium symporter
reversible: false
fast: false

metaR NACHEX25ly
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110004#
fast: false
product: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR FAOXC225C226x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

metaR CLPNDCOAtx
name: fatty acid intracellular transport
reversible: true
type: Reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110004#
fast: false
is described by: ECO:0000000

metaM glx c
type: Species
is: CHEBI:36655
initial concentration: 1.0
name: glyoxylate
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00119
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
has only substance units: false
constant: false

metaR r2518
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
fast: false
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110004#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1

http://identifiers.org/biomodels.db/MODEL1310110004#_a9407d84_6155_4f1b_bc10_db8baed5707d
has only substance units: false
name: ALG2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:85365
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_5c861011_acb4_4238_a634_a3c4db207ac9
constant: false
is: SBO:0000252
is: O95864
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:9415
initial concentration: NaN
name: FADS2

http://identifiers.org/biomodels.db/MODEL1310110004#_19aa1e96_b975_4b71_afdc_4a3bbf51d7d3
name: SULT1A2
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6799
initial amount: NaN

metaM met L c
name: L-methionine
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:16643
is: HMDB00696
type: Species
boundary condition: false
initial concentration: 1.0

metaR r1772
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
reversible: false
type: Reaction
modifier: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110004#

metaM decdicrn c
notes: FORMULA: C17H29NO4 CHARGE: 0
constant: false
initial concentration: 1.0
name: decadienoyl carnitine
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB13325
has only substance units: false
type: Species

metaM ksii core2 pre10 g
initial amount: NaN
has only substance units: false
is: CHEBI:28067
name: keratan sulfate II biosynthesis, precursor 10
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
constant: false
type: Species
is: SBO:0000247

metaM so4 e
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species
has only substance units: false
is: CHEBI:16189
name: sulfate
is: HMDB01448
constant: false
initial amount: NaN
boundary condition: false

metaM met L e
boundary condition: false
is: CHEBI:16643
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: SBO:0000247
constant: false
name: L-methionine
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00696

http://identifiers.org/biomodels.db/MODEL1310110004#_92585e37_bcfb_4a9b_929c_c6a7830f4b46
name: CROT
initial concentration: NaN
is encoded by: hsa:54677
type: Species
is: SBO:0000252
is: E7EQF2
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN

metaM asn L e
is: HMDB00168
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
is: CHEBI:17196
boundary condition: false
constant: false
initial concentration: 1.0
name: L-asparagine
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_04c16cc8_1d03_4e01_bf69_53fbf3ba5b44
boundary condition: true
constant: false
is: P49189
name: ALDH9A1
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:223
initial concentration: NaN
is: SBO:0000252

metaR RE2626C
kinetic law: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
reactant: MODEL1310110004#
is described by: ECO:0000000
name: RE2626
fast: false
type: Reaction
reversible: true

metaM 34hpp e
type: Species
is: HMDB00707
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:36242
is: SBO:0000247
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
initial amount: NaN
name: 3-(4-hydroxyphenyl)pyruvate

metaR r2517
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110004#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
fast: false
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

metaM ala D e
name: D-alanine
boundary condition: false
is: HMDB01310
is: SBO:0000247
has only substance units: false
is: CHEBI:15570
initial amount: NaN
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
type: Species
initial concentration: 1.0

metaM q10h2 m
constant: false
is: http://identifiers.org/pubchem.compound/6504740
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB13111
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
name: Ubiquinol-10
initial amount: NaN

metaR r1464
type: Reaction
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110004#
name: Active transport
is: SBO:0000185
reactant: MODEL1310110004#
fast: false

metaR EX c16dc
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecanedioic acid mono-L-carnitine ester
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_0dae186b_21b8_489f_a154_ca294e900acd
is: SBO:0000252
name: PDE4B
is: Q5TEK5
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5142

metaR FAOXTC142TC122m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

metaM cmpacna g
type: Species
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
boundary condition: false
is: HMDB01176
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57812
constant: false

metaR PDX5PO
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
kinetic law: MODEL1310110004#
name: pyridoxine 5'-phosphate oxidase
fast: false
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.4.3.5
reversible: true
reactant: MODEL1310110004#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
modifier: MODEL1310110004#

metaR GBSIDEtl
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) NJ
fast: false
reactant: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: globoside intracellular transport
product: MODEL1310110004#
reversible: true

metaM glygn4 e
type: Species
notes: FORMULA: C18H31O16X CHARGE: 0
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:4167
initial amount: NaN
is: SBO:0000247
is: HMDB00122
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})

http://identifiers.org/biomodels.db/MODEL1310110004#_7b758d68_9f5d_4499_965f_857a78a0f205
initial concentration: NaN
has only substance units: false
is: B7Z6Q4
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:3612
name: IMPA1

metaR r2516
fast: false
reversible: true
reactant: MODEL1310110004#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:
type: Reaction
is: SBO:0000185
product: MODEL1310110004#
kinetic law: MODEL1310110004#

metaR C100CPT1
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decanoylcarnitine
type: Reaction

metaR BTNDm
name: biotinidase (biotin), mitochondrial
is version of: http://identifiers.org/ec-code/3.5.1.12
reactant: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
product: MODEL1310110004#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110004#
is: SBO:0000176

metaR PTCRTD
name: diffusion of putriscine into the endothelial cells
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
reversible: true
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110004#
fast: false
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#

metaM prostge2 c
name: prostaglandin E2(1-)
is: SBO:0000247
is: CHEBI:606564
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: HMDB01220
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false

metaM abt c
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
name: L-arabinitol
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:18403
is: SBO:0000247
is: HMDB01851
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_c574055e_2c4f_431c_a738_b5015c18a57e
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:8140
is: Q8IV97
type: Species
is: SBO:0000252
name: SLC7A5

metaM hexdtrcoa m
is: SBO:0000247
name: 7,10,13-hexadecatrienoylcoa
type: Species
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
is: HMDB02288
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0

metaR NH4tn
reversible: true
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
fast: false
kinetic law: MODEL1310110004#
name: ammonia nuclear transport

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

metaR BILIRED
modifier: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.24
reversible: false
reactant: MODEL1310110004#
type: Reaction
is: SBO:0000176
name: Nad(p)h biliverdin reductase
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (645.1) or (644.1) SUBSYSTEM: Heme degradation EC Number: 1.3.1.24 Confidence Level: 0 AUTHORS: PMID:12456881,PMID:7656592,PMID:8117274 NOTES:TDV
fast: false

metaR r1020
kinetic law: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
type: Reaction
reversible: true
product: MODEL1310110004#
fast: false
is: SBO:0000185
reactant: MODEL1310110004#
name: Postulated transport reaction

metaM decdicrn e
constant: false
notes: FORMULA: C17H29NO4 CHARGE: 0
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: decadienoyl carnitine
boundary condition: false
is: HMDB13325
type: Species

metaM asn L c
name: L-asparagine
type: Species
is: SBO:0000247
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
is: CHEBI:17196
initial concentration: 1.0
is: HMDB00168
constant: false
initial amount: NaN
boundary condition: false

metaR DOLPH Uer
is described by: ECO:0000000
name: Dolichol-phosphate phosphohydrolase, human (uterus)
reversible: false
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110004#
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:

metaR FACOAL204
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
product: MODEL1310110004#
fast: false
reversible: true
reactant: MODEL1310110004#
is described by: ECO:0000269
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
modifier: MODEL1310110004#
type: Reaction

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR r2105
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_63c103aa_934a_4ceb_862d_ec99b14c41ba
is: SBO:0000252
is encoded by: hsa:10555
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is: O15120
name: AGPAT2
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_b6d4c27c_cc16_4d37_ae2f_3651aa8b6d6a
initial amount: NaN
name: NME2
is: P22392
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:4831
boundary condition: true
type: Species
has only substance units: false

metaR AG13T17g
type: Reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
modifier: MODEL1310110004#
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
product: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110004#_63da40f9_e09f_40e4_9221_f7636171e9fc
constant: false
initial concentration: NaN
boundary condition: true
name: INPP4B
is: O15327
has only substance units: false
is encoded by: hsa:8821
initial amount: NaN
is: SBO:0000252
type: Species

metaR RE2079R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
name: RE2079
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
is described by: ECO:0000000
reversible: true
fast: false

metaM rbt c
initial concentration: 1.0
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
constant: false
type: Species
initial amount: NaN
is: HMDB00508
has only substance units: false
is: CHEBI:15963
name: D-ribitol
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_b2c17cd6_ec89_4d92_9b57_bf63911ee044
is encoded by: hsa:23057
type: Species
has only substance units: false
name: NMNAT2
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR FAOXC227C226m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

metaM fad e
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:16238
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB01248
is: C00016
type: Species
name: Flavin adenine dinucleotide oxidized
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016

metaM adrn e
type: Species
constant: false
name: adrenic acid
has only substance units: false
boundary condition: false
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
is: HMDB02226
initial concentration: 1.0
is: CHEBI:53487
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_586cfe16_62e3_45ab_8034_0feef86213f6
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:AV713053
initial amount: NaN
name: _AV713053_1_m
is: SBO:0000252
type: Species
initial concentration: NaN

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaM fad c
name: Flavin adenine dinucleotide oxidized
is: HMDB01248
initial concentration: 1.0
initial amount: NaN
constant: false
is: C00016
is: CHEBI:16238
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
type: Species
boundary condition: false
has only substance units: false

metaM fuc L e
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: L-fucose
constant: false
is: CHEBI:18287
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
has only substance units: false
type: Species
is: HMDB00174

metaR r1881
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reversible: false
product: MODEL1310110004#
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110004#
reactant: MODEL1310110004#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_6a62bd20_f506_4433_bee3_5550def26938
name: _AI926493_1_c
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AI926493
initial concentration: NaN
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_f3fb812d_4832_402b_9a53_20841bd55457
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: OCRL
is encoded by: hsa:4952

metaR FACOAL205
modifier: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
reversible: true
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110004#

metaR r2104
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110004#
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_eff7e0ce_7a04_4165_930d_e743c19311e2
has part: E5KS60
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: SUCLG1:SUCLA2
is: SBO:0000297
boundary condition: true
is encoded by: hsa:8803

metaR r1179
name: EC:3.1.1.13
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110004#
reversible: false
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
fast: false

metaM pd3 c
initial amount: NaN
boundary condition: false
type: Species
constant: false
name: Previtamin D3
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1
initial concentration: 1.0
is: HMDB06500
is: SBO:0000247

metaR MEVK1x
notes: GENE_ASSOCIATION: (4598.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.1.36 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version NJ
reactant: MODEL1310110004#
reversible: false
kinetic law: MODEL1310110004#
name: mevalonate kinase (atp)
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.36

http://identifiers.org/biomodels.db/MODEL1310110004#_3eef151e_64de_4175_a809_6894fe59183c
is: O95168
name: NDUFB4
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:4710
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_0ca0d8cc_d832_4559_bd6c_918eae0ad9cc
is encoded by: hsa:3614
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: B3KRZ3
name: IMPDH1
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_f8ba75f9_3b76_4cd6_9d03_9ccab7a5d867
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:23556
initial amount: NaN
name: PIGN
is: SBO:0000252
has only substance units: false

metaR B3GNT33g
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110004#
is described by: ECO:0000269
product: MODEL1310110004#
fast: false
reversible: false
modifier: MODEL1310110004#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110004#

metaR r2107
modifier: MODEL1310110004#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110004#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_eab046fb_16e7_45ed_9938_bc06711fe6a9
type: Species
has only substance units: false
is: P17812
name: CTPS1
initial amount: NaN
is encoded by: hsa:1503
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252

metaM adrn c
initial amount: NaN
boundary condition: false
constant: false
name: adrenic acid
is: HMDB02226
is: CHEBI:53487
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false

metaM 4aphdob c
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
is: HMDB00978
has only substance units: false
type: Species
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
initial amount: NaN
is: CHEBI:58147

metaR GPIAT
fast: false
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
is: SBO:0000176
product: MODEL1310110004#
name: glucosaminylphosphatidyl inositol acetyltransferase
type: Reaction
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110004#

metaR DOLPGT2 Uer
is version of: http://identifiers.org/ec-code/2.4.1.265
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
type: Reaction
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
reversible: false
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)

http://identifiers.org/biomodels.db/MODEL1310110004#_6266bcdb_6601_4af8_8db9_e118b3893508
is: SBO:0000252
is encoded by: hsa:6568
is: Q14916
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
name: SLC17A1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_f0916dae_b99f_4b92_9e4a_c085faf35074
has part: P57054
constant: false
is encoded by: hsa:9091
is encoded by: hsa:51227
initial amount: NaN
boundary condition: true
has part: B2RAU6
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
is encoded by: hsa:5279
has only substance units: false
type: Species
is: SBO:0000297
is encoded by: hsa:5277
initial concentration: NaN

metaR r2106
type: Reaction
fast: false
modifier: MODEL1310110004#
is: SBO:0000185
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110004#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_7ea98edf_6263_4e20_8b21_d30cf82ed612
has part: O00459
is encoded by: hsa:5296
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:5290
initial amount: NaN
name: PIK3CA:PIK3R2
has part: P42336
is: SBO:0000297
type: Species
initial concentration: NaN

metaR r0224
modifier: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
kinetic law: MODEL1310110004#
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
reversible: false
reactant: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
is: SBO:0000176
is described by: ECO:0000000

metaR FACOAL203
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
name: fatty-acid--CoA ligase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110004#
is: SBO:0000176
fast: false

metaR FAOXC225C226m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

metaM lpam m
type: Species
name: lipoamide
is: CHEBI:17460
initial amount: NaN
is: HMDB00962
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
boundary condition: false
has only substance units: false
constant: false

metaM fuc L c
initial concentration: 1.0
is: HMDB00174
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
type: Species
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
initial amount: NaN
is: CHEBI:18287
name: L-fucose

metaR CYTK10n
is: SBO:0000176
name: cytidylate kinase (CMP,dGTP),nuclear
modifier: MODEL1310110004#
fast: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110004#
is described by: ECO:0000269
type: Reaction

metaM bildglcur c
is: HMDB03325
is: CHEBI:58471
constant: false
initial amount: NaN
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR S6TASE24ly
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
type: Reaction
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_9e3cc4a1_a263_4550_9684_af9d2b696ef9
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: B1AK53
name: ESPN
type: Species
is encoded by: hsa:83715

metaR C4STMO2Pr
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
name: C-4 methyl sterol oxidase
fast: false
reactant: MODEL1310110004#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.1.1.170
reversible: false
is described by: ECO:0000000
product: MODEL1310110004#

metaM 3octdeccrn e
is: HMDB13336
boundary condition: false
name: 3-hydroxyoctadecanoyl carnitine
notes: FORMULA: C25H49NO5 CHARGE: 0
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species

metaR DATPtn
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reactant: MODEL1310110004#
name: dATP diffusion in nucleus

metaR RTOTALt
reversible: true
name: RTOTAL transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaM so4 c
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
is: HMDB01448
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:16189
name: sulfate
is: SBO:0000247

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM chlstol r
has only substance units: false
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
is: HMDB06842
constant: false
name: 5alpha-cholesta-7,24-dien-3beta-ol
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16290
boundary condition: false
is: SBO:0000247

metaR r2511
kinetic law: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
name: Utilized transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110004#
type: Reaction

metaR FACOAL200
reactant: MODEL1310110004#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110004#
reversible: true
name: fatty-acid--CoA ligase
is: SBO:0000176
kinetic law: MODEL1310110004#
fast: false
product: MODEL1310110004#

metaR HSD3A1r
kinetic law: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
modifier: MODEL1310110004#
is: SBO:0000176
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110004#
reversible: true
fast: false

metaM pydx c
type: Species
initial concentration: 1.0
name: Pyridoxal
boundary condition: false
is: HMDB01545
is: C00250
is: SBO:0000247
initial amount: NaN
is: CHEBI:17310
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
constant: false
has only substance units: false

metaR r2101
is: SBO:0000185
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

metaM q10h2 c
initial concentration: 1.0
is: HMDB13111
boundary condition: false
name: Ubiquinol-10
initial amount: NaN
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6504740
has only substance units: false
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324

metaR DATPtm
is: SBO:0000185
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID: 16816105, PMID: 17403938. NOTES:
is described by: ECO:0000134
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
name: transport of dATP into mitochondria
fast: false
reversible: false

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaM ksi pre22 g
has only substance units: false
type: Species
boundary condition: false
is: HMDB00175
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
is: C00130
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58053
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 22
constant: false

metaR Asn X Ser Thrtr
is described by: ECO:0000269
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
name: Asn-X-Ser/Thr transport (from ER to lysosome)
is: SBO:0000185

metaM c12dc x
is: C05279
initial concentration: 1.0
constant: false
has only substance units: false
name: dodecanedioyl carnitine
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C19H34NO6 CHARGE: -1
is: HMDB11123

metaR CHATn
modifier: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.6
fast: false
name: Choline O-acetyltransferase
type: Reaction
reversible: true
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

metaR PTDCAt
name: fatty acid transport via diffusion
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000

metaR r0226
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:16171773,PMID:1631094,PMID:6882460,PMID:962851 NOTES:
kinetic law: MODEL1310110004#
reversible: false
product: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
is: SBO:0000176
name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase One carbon pool by folate / Folate biosynthesis EC:1.5.1.3
is described by: ECO:0000000
modifier: MODEL1310110004#

metaR r2100
fast: false
modifier: MODEL1310110004#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaM glyphe e
name: Glycylphenylalanine
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C11H14N2O3 CHARGE: 0
type: Species
is: http://identifiers.org/pubchem.compound/97415
has only substance units: false
constant: false

metaR HSAT2ly
type: Reaction
reversible: false
product: MODEL1310110004#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
kinetic law: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM 3octdeccrn c
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C25H49NO5 CHARGE: 0
initial amount: NaN
name: 3-hydroxyoctadecanoyl carnitine
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB13336

metaM lnlncgcoa m
initial concentration: 1.0
name: gamma-linolenoyl-CoA(4-)
is: CHEBI:57363
boundary condition: false
constant: false
is: HMDB06368
is: SBO:0000247
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
initial amount: NaN
has only substance units: false
type: Species

metaR C8CRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

metaR PI4PLC
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
product: MODEL1310110004#
reversible: false
kinetic law: MODEL1310110004#
name: phosphatidylinositol 4-phosphate phospholipase C
modifier: MODEL1310110004#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
is described by: ECO:0000269

metaM bildglcur e
name: bis(beta-glucosyluronate)bilirubin
initial amount: NaN
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
boundary condition: false
has only substance units: false
is: CHEBI:58471
constant: false
is: HMDB03325
type: Species
is: SBO:0000247
initial concentration: 1.0

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR NDPK7n
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110004#_05454ccf_9d83_49c5_820d_1a0b9ab620f2
name: ALG3
boundary condition: true
is encoded by: hsa:10195
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false

metaR ALAGLYexR
is: SBO:0000185
product: MODEL1310110004#
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: true
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-alanine/glycine reversible exchange
reactant: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_d37d647f_ab11_449c_9148_c02a59a08561
constant: false
has only substance units: false
is encoded by: hsa:T83654
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
name: _T83654_1_c

metaM pyam5p c
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: C00647
is: HMDB01555
is: SBO:0000247
constant: false
type: Species
is: CHEBI:58451
name: Pyridoxamine 5'-phosphate
initial amount: NaN

metaM hyptaur c
initial amount: NaN
is: HMDB00965
boundary condition: false
is: CHEBI:16668
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
constant: false
has only substance units: false
initial concentration: 1.0
name: Hypotaurine
is: SBO:0000247
type: Species

metaR S6T14g
type: Reaction
kinetic law: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110004#
is described by: ECO:0000000

metaM 56dthm c
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: HMDB00079
boundary condition: false
is: CHEBI:27468
name: 5,6-dihydrothymine
is: SBO:0000247
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906

metaM q10h2 e
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6504740
name: Ubiquinol-10
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
type: Species
is: HMDB13111
has only substance units: false

metaR r2103
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185

metaR FUCtly
reversible: false
type: Reaction
is: SBO:0000185
name: L-fucose efflux from lysosome
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:
fast: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

metaR NDPK3m
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
reactant: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000176
reversible: true

metaR r1779
modifier: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
fast: false
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_98e602f3_40a0_4094_a6bc_5a0b4f5b7ef5
constant: false
has only substance units: false
is: SBO:0000252
is: Q8IXK2
type: Species
name: GALNT12
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:79695
boundary condition: true

metaM HC01377 m
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-10(2)9-13(16)18-8-7-11(17)5-3-4-6-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05119
type: Species
constant: false
initial concentration: 1.0
name: S-(3-Methylbutanoyl)-dihydrolipoamide
is: CHEBI:27462
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_b061965c_d35e_4c96_bffe_e72d294e4c90
is encoded by: hsa:6392
has part: O14521
constant: false
is encoded by: hsa:6389
is: SBO:0000297
has part: P31040
has part: P21912
has only substance units: false
has part: Q99643
initial amount: NaN
initial concentration: NaN
name: SDHA:SDHB:SDHC:SDHD
boundary condition: true
type: Species
is encoded by: hsa:6391
is encoded by: hsa:6390

metaR 4MOPte
name: Transport of 4-methyl-2-oxopentanoate
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
fast: false
is: SBO:0000185

metaM rbt e
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
name: D-ribitol
constant: false
is: CHEBI:15963
is: HMDB00508
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
boundary condition: false

metaM 3otdcoa m
type: Species
boundary condition: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28726
name: 3-Oxotetradecanoyl-CoA
is: HMDB03935

http://identifiers.org/biomodels.db/MODEL1310110004#_8c2f6666_8c98_40e3_ac2a_8a642abde444
name: SYNJ2
initial amount: NaN
is: SBO:0000252
is: O15056
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:8871

metaM glx m
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial concentration: 1.0
is: CHEBI:36655
constant: false
initial amount: NaN
is: HMDB00119
boundary condition: false
name: glyoxylate
is: SBO:0000247
type: Species
has only substance units: false

metaM dece3coa m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
has only substance units: false
name: 3-decenoylcoa

metaR r2102
reversible: true
modifier: MODEL1310110004#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR BTNDe
name: biotinidase (biotin), extracellular
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
type: Reaction
is described by: ECO:0000269
fast: false
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.5.1.12
kinetic law: MODEL1310110004#
is: SBO:0000176
reversible: false

metaM glyphe c
constant: false
name: Glycylphenylalanine
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C11H14N2O3 CHARGE: 0
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/97415

metaM leuktrC4 e
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
type: Species
is: HMDB01198
is: CHEBI:57973
has only substance units: false
name: leukotriene C4(2-)
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_548613b8_224b_49b0_a238_f2ffcc524d96
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: _AI620219_1_c
boundary condition: true
is encoded by: hsa:AI620219

http://identifiers.org/biomodels.db/MODEL1310110004#_0922cdeb_8032_4781_a3c7_c3b019e4799c
name: _N63787_1_c
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:N63787
initial amount: NaN

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_8d7264a1_20f1_493b_a684_f2c9ad4c6cb6
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: Q16822
is encoded by: hsa:5106
name: PCK2
has only substance units: false

metaR LALDO
modifier: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
reactant: MODEL1310110004#
product: MODEL1310110004#
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
kinetic law: MODEL1310110004#
fast: false

metaM leuktrC4 c
is: HMDB01198
is: CHEBI:57973
name: leukotriene C4(2-)
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM HC02175 c
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial concentration: 1.0
is: CHEBI:27689
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
name: caprate
initial amount: NaN
constant: false

metaR UMPK6
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110004#
name: UMP kinase (dCTP)
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110004#
product: MODEL1310110004#

metaR TIGCRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaM mn l
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB06535
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
type: Species
initial concentration: 1.0
name: beta-1,4-mannose-N-acetylglucosamine

http://identifiers.org/biomodels.db/MODEL1310110004#_55fa5cb8_82ee_46cb_bacf_30e56de54224
name: ENTPD1
constant: false
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q86VV3
is encoded by: hsa:953
initial amount: NaN
is: SBO:0000252

metaR FAOXC225C204m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaR NDPK10n
fast: false
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
modifier: MODEL1310110004#
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
reversible: true

metaR r0399
kinetic law: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
fast: false
reversible: true
is: SBO:0000176
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
modifier: MODEL1310110004#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.4.2
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1

metaR TETPENT6t
type: Reaction
name: fatty acid transport via diffusion
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
is: SBO:0000185
fast: false

metaR TRPHYDRO2
reactant: MODEL1310110004#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110004#
product: MODEL1310110004#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
is version of: http://identifiers.org/ec-code/1.14.16.4
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
reversible: false
fast: false

metaM fad m
initial amount: NaN
is: CHEBI:16238
constant: false
is: HMDB01248
is: C00016
name: Flavin adenine dinucleotide oxidized
type: Species
is: SBO:0000247
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
boundary condition: false
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_01b10d04_e49a_466e_a799_ced649a1a8fc
has only substance units: false
name: ST3GAL3
initial amount: NaN
is encoded by: hsa:6487
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true

metaM doldp U r
name: Dolichol diphosphate, human uterine homolog
initial amount: NaN
is: CHEBI:15750
boundary condition: false
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
constant: false

metaR RPI
reversible: true
type: Reaction
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/5.3.1.6
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
name: ribose-5-phosphate isomerase
fast: false
reactant: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_e470e8fa_c06b_4275_ae97_79d45041ea82
initial amount: NaN
is: Q9NRX3
has only substance units: false
is encoded by: hsa:56901
is: SBO:0000252
constant: false
name: NDUFA4L2
type: Species
initial concentration: NaN
boundary condition: true

metaM dolglcp U r
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15812

metaR UMPK7
kinetic law: MODEL1310110004#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
modifier: MODEL1310110004#
name: UMP kinase (dGTP)
is: SBO:0000176
is described by: ECO:0000269

metaR MECOAS1m
reversible: true
is: SBO:0000176
modifier: MODEL1310110004#
type: Reaction
fast: false
kinetic law: MODEL1310110004#
name: mesaconate--CoA ligase (GDP-forming)
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
is described by: ECO:0000304
reactant: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.2.1.4

http://identifiers.org/biomodels.db/MODEL1310110004#_3862cb45_242e_4737_b1e3_82c418dcd4b5
is: P50993
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:477
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: ATP1A2

metaM glx x
initial amount: NaN
initial concentration: 1.0
is: CHEBI:36655
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
type: Species
is: HMDB00119
name: glyoxylate

metaR B3GNT11g
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: (10678.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
reactant: MODEL1310110004#
is described by: ECO:0000269

metaR DOLPMT2 Uer
product: MODEL1310110004#
reversible: false
kinetic law: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reactant: MODEL1310110004#
fast: false

metaM strch1 e
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]})
is: SBO:0000247
is: CHEBI:456215
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C66H112O56 CHARGE: 0
constant: false
is: HMDB00045
is: C00020
has only substance units: false

metaR S6T13g
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110004#
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reactant: MODEL1310110004#

metaR NDPK8n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
kinetic law: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
fast: false
is: SBO:0000176
product: MODEL1310110004#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
reactant: MODEL1310110004#

metaR SUCOASm
is described by: ECO:0000000
modifier: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
kinetic law: MODEL1310110004#
name: Succinate--CoA ligase (ADP-forming)
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.2.1.5
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110004#
type: Reaction
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_54362f13_15b5_45b3_b280_4cef584b404a
name: MAN1B1
is encoded by: hsa:11253
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: Q9UKM7
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_c8cfebc1_abde_4163_a9af_caecd846a304
is encoded by: hsa:5092
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
name: PCBD1
initial concentration: NaN
constant: false

metaR EX 3deccrn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydecanoyl carnitine
type: Reaction

metaR EX lgnc LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: lignoceric acid exchange
type: Reaction

metaR RPE
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110004#
name: ribulose 5-phosphate 3-epimerase
kinetic law: MODEL1310110004#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/5.1.3.1
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
is: SBO:0000176
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_3c938cd9_e3af_4aec_84ce_6bc4904d7344
boundary condition: true
initial concentration: NaN
is: Q9UEF7
has only substance units: false
name: KL
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:9365

metaR UMPK4
reactant: MODEL1310110004#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110004#
name: UMP kinase (GTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110004#
is described by: ECO:0000269
reversible: true
product: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM tym c
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB00306
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
constant: false
name: tyraminium
boundary condition: false
is: CHEBI:327995

metaR PI4PLCn
is: SBO:0000176
reversible: false
reactant: MODEL1310110004#
product: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110004#
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.11
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110004#_6490f10c_747c_4587_8402_af58824902b3
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:5152
name: PDE9A
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r0669
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
reversible: false
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:

metaR r1019
name: Postulated transport reaction
fast: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
type: Reaction
product: MODEL1310110004#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_48488ac9_5359_4d1a_9357_2118e54354e3
is encoded by: hsa:9374
name: PPT2
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: Q9UMR5

metaM tdcoa m
initial concentration: 1.0
type: Species
is: CHEBI:57385
name: Tetradecanoyl-CoA (n-C14:0CoA)
constant: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
has only substance units: false
is: HMDB01521
initial amount: NaN
boundary condition: false
is: C02593
is: SBO:0000247

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR F6Tg
is: SBO:0000176
fast: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
is described by: ECO:0000000
type: Reaction
product: MODEL1310110004#
reactant: MODEL1310110004#
name: glycoprotein 6-alpha-L-fucosyltransferase
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.68
modifier: MODEL1310110004#

metaR UMPK5
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
product: MODEL1310110004#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110004#
modifier: MODEL1310110004#
reversible: true
name: UMP kinase (dATP)
kinetic law: MODEL1310110004#
is: SBO:0000176

metaR RE0383C
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.2
name: RE0383
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110004#_5d074ed1_2de1_472f_9e18_294d5f3a8e0a
is: P16930
boundary condition: true
type: Species
is encoded by: hsa:2184
name: FAH
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR SMPD4
is described by: ECO:0000000
name: sphingomyelinase
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
fast: false
product: MODEL1310110004#
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_c32dfb83_9734_47e5_988d_e39f5718a471
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: _H77542_1_r
constant: false
is encoded by: hsa:H77542

http://identifiers.org/biomodels.db/MODEL1310110004#_d0953939_4a6d_419c_b9d2_777b0bc2259e
is encoded by: hsa:5152
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: PDE9A
is: SBO:0000252
has only substance units: false
type: Species

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

metaR FAOXC163GC142m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaM dcsptn1coa c
constant: false
boundary condition: false
type: Species
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205483
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: HMDB06513
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: C16173
initial amount: NaN

metaR FALDH
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110004#
modifier: MODEL1310110004#
name: formaldehyde dehydrogenase
product: MODEL1310110004#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_8b6670c2_56df_4cdb_82d7_f48521866b62
name: PIK3R1
is encoded by: hsa:5295
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: B3KT19

metaR ACONTm
product: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
name: Aconitate hydratase
reversible: true
kinetic law: MODEL1310110004#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/4.2.1.3
is: SBO:0000176
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_6838a323_81c9_4067_8f1a_7dbb3be21f06
constant: false
is: SBO:0000297
name: EHHADH:ACAA1:ACOX1
initial concentration: NaN
has part: Q9NY65
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:1962

metaR r0668
modifier: MODEL1310110004#
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
product: MODEL1310110004#
type: Reaction
fast: false
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.2.19
is: SBO:0000176
reactant: MODEL1310110004#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:

metaR FAOXC14C14OHm
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C14OH)m
type: Reaction

metaM CE5118 m
initial amount: NaN
is: SBO:0000247
is: CHEBI:57923
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA
boundary condition: false

metaR r0395
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:
reactant: MODEL1310110004#
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110004#
name: Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2

http://identifiers.org/biomodels.db/MODEL1310110004#_61780726_bf96_4310_aeda_0b3f4d205975
has only substance units: false
name: SLCO2A1
type: Species
is encoded by: hsa:6578
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q92959

metaR FAOXC165C164x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:5-->C16:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_fc5a2667_95d9_46d3_962f_8b00c77e6763
name: FASN
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: P49327
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2194

http://identifiers.org/biomodels.db/MODEL1310110004#_682b74d3_e9e5_4aae_98d6_7a1d525a67c3
has only substance units: false
name: PMM1
is encoded by: hsa:5372
is: SBO:0000252
type: Species
constant: false
is: A8K003
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR DOLGLCP Uter
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000185
product: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)

metaM HC01399 m
name: (S)-3-Hydroxytetradecanoyl-CoA
is: CHEBI:27466
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
type: Species
initial amount: NaN
is: SBO:0000247

metaR FAOXC101C102m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

metaM bhb c
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247
constant: false
is: HMDB00011
initial amount: NaN
name: (R)-3-hydroxybutyrate
is: CHEBI:10983

metaM amet c
name: S-Adenosyl-L-methionine
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial concentration: 1.0
type: Species
initial amount: NaN
is: C00019
is: CHEBI:15414
is: HMDB01185
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEte
is: SBO:0000185
fast: false
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
type: Reaction
is described by: ECO:0000000
name: blood group intracellular transport
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_ac0cc5d9_a649_4cd5_9e94_ba4f7a6d98fc
boundary condition: true
is encoded by: hsa:6241
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P31350
is: SBO:0000252
name: RRM2
constant: false

metaM sphmyln hs c
is: CHEBI:58216
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
type: Species
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: sphingomyelin betaine
boundary condition: false

metaM g3p c
name: Glyceraldehyde 3-phosphate
initial amount: NaN
is: C00661
has only substance units: false
initial concentration: 1.0
is: CHEBI:58027
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3930
type: Species
is: SBO:0000247
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: HMDB01112

http://identifiers.org/biomodels.db/MODEL1310110004#_54b8bcad_3265_40df_b9bb_f31d7df896f2
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AI935189
name: _AI935189_1_m

metaR TYRCBOX
fast: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
modifier: MODEL1310110004#
product: MODEL1310110004#
reversible: false
name: L-Tyrosine carboxy-lyase
type: Reaction
reactant: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.28
is described by: ECO:0000134

metaR XYLtly
product: MODEL1310110004#
fast: false
type: Reaction
is: SBO:0000185
reversible: false
name: Xylose efflux from lysosome
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
reactant: MODEL1310110004#
is described by: ECO:0000000

metaR r0394
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110004#
is described by: ECO:0000000
fast: false
reversible: true

metaM lnlncgcoa c
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:57363
type: Species
name: gamma-linolenoyl-CoA(4-)
is: HMDB06368
initial amount: NaN
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035

http://identifiers.org/biomodels.db/MODEL1310110004#_fdba3393_9fc5_45c0_80a0_e4048fbb1a66
boundary condition: true
is encoded by: hsa:5230
is: SBO:0000252
initial amount: NaN
name: PGK1
type: Species
has only substance units: false
is: P00558
initial concentration: NaN
constant: false

metaM thymd c
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
constant: false
type: Species
has only substance units: false
is: CHEBI:17748
boundary condition: false
initial concentration: 1.0
is: HMDB00273
initial amount: NaN
is: C00214
name: Thymidine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_0faee50c_f745_4b6c_9285_685f22787aa9
is: SBO:0000252
name: _642502_1_c
boundary condition: true
is encoded by: hsa:642502
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR DM dgpi prot hs r
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

metaR C18OHc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecanoylcarnitine
type: Reaction

metaM ocdececrn m
initial amount: NaN
has only substance units: false
notes: FORMULA: C25H47NO4 CHARGE: 0
constant: false
is: SBO:0000247
name: 11-octadecenoyl carnitine
is: HMDB06351
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_1b9e349a_9cc6_4020_a1af_b29687bb58cc
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6482
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: ST3GAL1
is: SBO:0000252

metaR r0666
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
reactant: MODEL1310110004#
product: MODEL1310110004#
reversible: true
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
is version of: http://identifiers.org/ec-code/1.2.4.2
is: SBO:0000176
type: Reaction
modifier: MODEL1310110004#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110004#

metaM utp n
initial amount: NaN
name: UTP(4-)
is: CHEBI:46398
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB00285
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_4767b302_1a95_42e5_92fc_4168a72cbca4
is encoded by: hsa:53354
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: PANK1
type: Species
is: Q8TE04

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaR FATP2t
is described by: ECO:0000269
modifier: MODEL1310110004#
reversible: true
name: fatty acid electroneutral transport
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
reactant: MODEL1310110004#

metaR ACACT5p
reactant: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110004#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
modifier: MODEL1310110004#
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_2a5566a1_8d6d_4f43_9c93_ba7ebec4db23
type: Species
boundary condition: true
constant: false
is: Q9NT06
initial amount: NaN
name: HMGCLL1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54511

http://identifiers.org/biomodels.db/MODEL1310110004#_7fd04a47_e73d_41b0_9215_40616288dc07
is: SBO:0000252
initial amount: NaN
is: Q92535
name: PIGC
constant: false
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5279

metaR BUP2
fast: false
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.5.1.6
reversible: false
name: beta-ureidopropionase (D-3-amino-isobutanoate forming)
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:11508704,PMID:5773299 NOTES:MM
reactant: MODEL1310110004#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000269
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
fast: false
type: Reaction
product: MODEL1310110004#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000185
name: blood group intracellular transport

metaR GLCNACASE2ly
type: Reaction
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
product: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reversible: false
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.50
name: alpha-N-acetylglucosaminidase, lysosomal
fast: false
is: SBO:0000176

metaR EX 5mthf LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 5-Methyltetrahydrofolate
type: Reaction

metaM HC00695 m
name: S-Succinyldihydrolipoamide
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
boundary condition: false
is: CHEBI:17432

http://identifiers.org/biomodels.db/MODEL1310110004#_0fd9b826_da24_481e_afd0_91f74892b71f
boundary condition: true
has only substance units: false
is encoded by: hsa:54
constant: false
is: SBO:0000252
initial amount: NaN
type: Species
is: P13686
name: ACP5
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_3a870850_db7f_43af_9ea0_486d5447020c
is encoded by: hsa:137964
boundary condition: true
name: AGPAT6
constant: false
type: Species
initial amount: NaN
is: Q86UL3
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR GRTTx
is version of: http://identifiers.org/ec-code/2.5.1.1
reversible: false
reactant: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#
fast: false
is described by: ECO:0000134
name: geranyltranstransferase
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
kinetic law: MODEL1310110004#
type: Reaction

metaM 2oxoadp m
type: Species
is: HMDB00225
name: 2-oxoadipate(2-)
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:57499
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322

metaM HC02217 c
type: Species
is: CHEBI:27647
constant: false
is: SBO:0000247
has only substance units: false
name: prostaglandin-g2
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956

metaR r0391
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
reversible: true
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110004#_f172ec8f_7b57_44b0_8c19_1eca2627b7f8
type: Species
is encoded by: hsa:622
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: BDH1
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_fa1f5bf0_6cc4_4b16_886a_991fe8b084d3
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q5HYI4
constant: false
is encoded by: hsa:6713
has only substance units: false
name: SQLE

metaR HAS2
reactant: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.212
fast: false
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
name: hyaluronan synthase
product: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_06a04c1b_0dba_4cfc_b804_f117848d74dd
name: IMPDH1
initial amount: NaN
type: Species
is: SBO:0000252
is: C9JV30
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3614
constant: false

metaR r0390
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
reversible: true
type: Reaction
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
fast: false
kinetic law: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_7fa52ed1_0cea_4e57_b100_d7c103c9f319
initial concentration: NaN
boundary condition: true
is: O95954
is encoded by: hsa:10841
constant: false
has only substance units: false
name: FTCD
type: Species
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_f8fad197_c20d_42b3_b644_228d81e75fea
name: ENTPD2
is: Q5SPY7
type: Species
is encoded by: hsa:954
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaR HAS1
fast: false
type: Reaction
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.212
reversible: false
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
name: hyaluronan synthase
reactant: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110004#

metaM 25aics c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
is: CHEBI:58443
is: SBO:0000247
boundary condition: false
is: C04823
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
is: HMDB00797
type: Species
constant: false
has only substance units: false

metaR AG13T1g
is described by: ECO:0000000
kinetic law: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
reversible: false
fast: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110004#
modifier: MODEL1310110004#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction

metaM ocdececrn c
name: 11-octadecenoyl carnitine
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C25H47NO4 CHARGE: 0
constant: false
boundary condition: false
is: HMDB06351
initial concentration: 1.0
is: SBO:0000247

metaM 2docopencoa m
boundary condition: false
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
name: 2,7,10,13,16-docosapentenoylcoa
is: http://identifiers.org/pubchem.compound/24892790
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaM ksii core4 deg4 l
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C66H108N6O48SX CHARGE: -1
name: keratan sulfate II (core 4-linked), degradation product 4
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB01354
constant: false
is: CHEBI:57455

metaR r0393
is version of: http://identifiers.org/ec-code/2.7.1.74
product: MODEL1310110004#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
kinetic law: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
fast: false
is: SBO:0000176
reversible: false
reactant: MODEL1310110004#
is described by: ECO:0000000

metaM triodthy e
is: CHEBI:18258
type: Species
is: HMDB00265
has only substance units: false
is: SBO:0000247
name: 3,3',5-triiodo-L-thyronine
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465

metaR C4DCCACT
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

metaM cs c l
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: SBO:0000247
has only substance units: false
name: chondroitin sulfate C (GalNAc6S-GlcA), free chain
initial amount: NaN
is: HMDB02183
boundary condition: false
is: CHEBI:36005

metaR FAOXC225C204x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_3c9637be_cb6f_4a9e_92ab_dcf60daf4a1d
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6487
type: Species
initial amount: NaN
boundary condition: true
constant: false
name: ST3GAL3

metaM i c
has only substance units: false
is: HMDB12238
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:16382
name: iodide
constant: false
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
type: Species
initial amount: NaN

metaM tdcoa c
initial amount: NaN
boundary condition: false
constant: false
is: HMDB01521
initial concentration: 1.0
name: Tetradecanoyl-CoA (n-C14:0CoA)
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: C02593
type: Species
is: CHEBI:57385
has only substance units: false
is: SBO:0000247

metaR r0392
product: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is: SBO:0000176
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is described by: ECO:0000000
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_ed1c564b_df7b_44bc_915d_6a82a386ef3f
is encoded by: hsa:509
initial concentration: NaN
has part: P36542
has part: A8K092
is encoded by: hsa:514
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
constant: false
has part: P06576
is: SBO:0000297
is encoded by: hsa:498
type: Species
is encoded by: hsa:513
initial amount: NaN
has only substance units: false
boundary condition: true
has part: P56381
is encoded by: hsa:506
has part: P30049

metaR r0661
is: SBO:0000176
product: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: false

metaR GGH 5DHFe
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
product: MODEL1310110004#
fast: false
name: Gamma-glutamyl hydrolase (5DHF), extracellular
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000000
reversible: false

metaM 4mop m
is: HMDB00695
type: Species
name: 4-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17865
has only substance units: false
boundary condition: false
constant: false

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_ab6b722a_9ae9_4c23_b746_6300f67250fc
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55350
type: Species
is encoded by: hsa:8875
name: VNN3:VNN2:VNN1
has part: O95498
is: SBO:0000297
constant: false
boundary condition: true

metaM bhb e
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
name: (R)-3-hydroxybutyrate
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:10983
is: HMDB00011
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_2473958e_927a_4828_8d70_1412353c8b1f
is encoded by: hsa:9091
name: PIGQ
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: Q9BRB3
is: SBO:0000252

metaM so4 m
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
constant: false
initial amount: NaN
name: sulfate
is: HMDB01448

metaR ACACT1rm
type: Reaction
fast: false
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
is: SBO:0000176
name: acetyl-CoA C-acetyltransferase, mitochondrial
reversible: true
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
is version of: http://identifiers.org/ec-code/2.3.1.9
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR r0660
product: MODEL1310110004#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.2
is: SBO:0000176
reactant: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110004#

metaR UMPK2
product: MODEL1310110004#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110004#
type: Reaction
fast: false
name: UMP kinase (CTP)
kinetic law: MODEL1310110004#
is described by: ECO:0000269
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM mag hs c
constant: false
is: CHEBI:16521
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01251
has only substance units: false
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
name: monoacylglycerol 2
initial amount: NaN
is: SBO:0000247

metaM triodthy c
has only substance units: false
boundary condition: false
name: 3,3',5-triiodo-L-thyronine
initial concentration: 1.0
is: CHEBI:18258
is: SBO:0000247
is: HMDB00265
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465

metaR SIAASE4ly
product: MODEL1310110004#
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110004#

metaM ipdp x
is: CHEBI:128769
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
name: isopentenyl diphosphate(3-)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01347
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_0f7f0288_1120_4a6b_87ee_d823b7235aaf
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is: Q70HW3
boundary condition: true
is encoded by: hsa:115286
name: SLC25A26

metaR UMPK3
reversible: true
modifier: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
kinetic law: MODEL1310110004#
name: UMP kinase (UTP)
is described by: ECO:0000269
reactant: MODEL1310110004#
is: SBO:0000176

metaM i e
constant: false
initial concentration: 1.0
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
has only substance units: false
is: SBO:0000247
is: CHEBI:16382
type: Species
name: iodide
boundary condition: false
is: HMDB12238
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_9a59ddaa_a62b_4c34_85df_130030748f8c
type: Species
is: SBO:0000252
name: MUT
is encoded by: hsa:4594
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P22033

http://identifiers.org/biomodels.db/MODEL1310110004#_d64a56e4_a0e7_46ac_ab5b_428494cfe536
name: SLC7A8:SLC3A2
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000297
has part: Q86U05
boundary condition: true
constant: false
is encoded by: hsa:23428
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_6da42dee_7c31_4f6b_9d89_aaa2c7c2638a
boundary condition: true
is encoded by: hsa:AI972237
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
name: _AI972237_1_c
type: Species

metaM CE2839 e
type: Species
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: C01936
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
is: SBO:0000247
has only substance units: false
name: maltodecaose

metaR NAHCO3 HCLt
product: MODEL1310110004#
is described by: ECO:0000269
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
modifier: MODEL1310110004#
name: bicarbonate transport (HCl/NaHCO3 exchange)
fast: false
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#

metaR NTD7e
reversible: false
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
is: SBO:0000176
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:14578500 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
fast: false
name: 5'-nucleotidase (AMP), extracellular
is described by: ECO:0000269
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_c2bb940c_f668_41c3_ac6f_56e023d21c33
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: P21912
initial concentration: NaN
has only substance units: false
name: SDHB
is encoded by: hsa:6390

http://identifiers.org/biomodels.db/MODEL1310110004#_c1e3f84d_e464_4a2f_b392_e11f46e6dbd7
name: SLC4A5
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:57835
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_08d2d5ca_f34a_4067_b0bb_1197ab809a1d
constant: false
is: SBO:0000252
name: ACLY
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:47

http://identifiers.org/biomodels.db/MODEL1310110004#_1f1c9a2c_a5bb_4ab7_91c4_c2578275b71c
constant: false
is: Q99884
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6534
has only substance units: false
type: Species
initial amount: NaN
name: SLC6A7
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_a492c513_9e76_4852_ab68_363c22bfb413
type: Species
has part: P54709
has only substance units: false
initial amount: NaN
is: SBO:0000297
name: ATP1A1:ATP1B3
has part: B7Z3U6
constant: false
is encoded by: hsa:476
initial concentration: NaN
is encoded by: hsa:483
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_7538a145_e07d_4dba_80cf_22d5a07de9a1
has only substance units: false
boundary condition: true
name: LIPA
constant: false
initial amount: NaN
is: P38571
type: Species
initial concentration: NaN
is encoded by: hsa:3988
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_51efac6a_6b91_4f54_bb44_423760413a44
is: SBO:0000252
initial amount: NaN
name: PLCL1
type: Species
is encoded by: hsa:5334
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: Q15111

metaM HC02217 e
is: CHEBI:27647
boundary condition: false
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
name: prostaglandin-g2
initial concentration: 1.0

metaM mag hs e
name: monoacylglycerol 2
boundary condition: false
is: SBO:0000247
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:32391
type: Species
is: HMDB03073

metaR FADtru
type: Reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
reversible: false
fast: false
name: FAD transporter, endoplasmic reticulum
product: MODEL1310110004#
is: SBO:0000185

metaR EX 3thexddcoacrn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans7,10-hexadecadienoyl carnitine
type: Reaction

metaR GLU5Km
name: glutamate 5-kinase (m)
fast: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (5832.1) SUBSYSTEM: Urea cycle EC Number: 2.7.2.11 Confidence Level: 2 AUTHORS: PMID:10037775 NOTES:SAB m
is described by: ECO:0000254
modifier: MODEL1310110004#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110004#
reversible: false
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.2.1.41

metaM fad r
has only substance units: false
is: HMDB01248
type: Species
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
is: SBO:0000247
is: CHEBI:16238
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_4080e06e_1337_44be_bbd1_671f5adeb1b9
boundary condition: true
is: SBO:0000252
name: ALOX5
constant: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: P09917
is encoded by: hsa:240

metaM 3aib D m
has only substance units: false
is: SBO:0000247
name: D-3-Amino-isobutanoate
initial concentration: 1.0
is: C03265
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
boundary condition: false
type: Species
is: HMDB02299
initial amount: NaN

metaR r1459
reactant: MODEL1310110004#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110004#
type: Reaction
is: SBO:0000185
name: Transport reaction
fast: false

metaR RE2659R
reactant: MODEL1310110004#
name: RE2659
type: Reaction
kinetic law: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaR CYSSNAT5tc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r0512
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
fast: false
type: Reaction
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110004#

metaR EX c8crn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_52d7f97d_5a09_423d_b970_f6ecca28cdbe
constant: false
is: Q05932
initial concentration: NaN
is encoded by: hsa:2356
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
name: FPGS

http://identifiers.org/biomodels.db/MODEL1310110004#_39870109_a352_42a2_8fd3_993a02172139
initial concentration: NaN
is: P54687
has only substance units: false
is: SBO:0000252
type: Species
name: BCAT1
initial amount: NaN
constant: false
is encoded by: hsa:586
boundary condition: true

metaM utp e
initial amount: NaN
is: CHEBI:46398
is: HMDB00285
is: SBO:0000247
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
boundary condition: false
has only substance units: false
name: UTP(4-)
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_59ba11c9_ce69_40fb_a158_91f0e34ed07e
type: Species
is: P36269
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2687
name: GGT5
boundary condition: true

metaM akg c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00208
initial amount: NaN
has only substance units: false
name: 2-Oxoglutarate
type: Species
is: C00026
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: CHEBI:16810
constant: false

metaM bhb m
constant: false
initial concentration: 1.0
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species
is: HMDB00011
initial amount: NaN
is: SBO:0000247
name: (R)-3-hydroxybutyrate
boundary condition: false
has only substance units: false
is: CHEBI:10983

http://identifiers.org/biomodels.db/MODEL1310110004#_d442082f_1239_4ca5_add2_2e2c233a4680
is: Q92820
initial concentration: NaN
is encoded by: hsa:8836
type: Species
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
name: GGH
initial amount: NaN

metaR ADPACTD
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

metaM btn c
has only substance units: false
notes: FORMULA: C10H15N2O3S CHARGE: -1
initial concentration: 1.0
is: CHEBI:3420
initial amount: NaN
boundary condition: false
is: HMDB00030
constant: false
is: SBO:0000247
is: C00120
type: Species
name: Biotin

metaM nmn c
constant: false
initial concentration: 1.0
is: C00455
boundary condition: false
name: NMN
is: SBO:0000247
is: HMDB00229
is: CHEBI:14649
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
has only substance units: false
initial amount: NaN
type: Species

metaM tethex3 e
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
name: tetracosahexaenoic acid, n-3
is: HMDB02007
initial amount: NaN
boundary condition: false
type: Species

metaM xol7ah2 c
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB06893
is: CHEBI:28047
initial amount: NaN
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
name: 5beta-cholestane-3alpha,7alpha-diol

http://identifiers.org/biomodels.db/MODEL1310110004#_bef5986c_53b6_465c_8c46_0f722e27a482
name: PIK3R5:PIK3CG
boundary condition: true
initial amount: NaN
is encoded by: hsa:23533
is: SBO:0000297
constant: false
has part: Q8WYR1
type: Species
has only substance units: false
initial concentration: NaN

metaM leu L c
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: L-leucine
is: SBO:0000247
has only substance units: false
is: HMDB00687
type: Species
is: CHEBI:15603
constant: false

metaM HC02210 c
constant: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
type: Species
name: prostaglandin-d3
is: CHEBI:34939
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaR r2111
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
reactant: MODEL1310110004#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
product: MODEL1310110004#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_712b6793_0321_421d_bbc2_ebad1c920575
is encoded by: hsa:7264
is: Q13630
type: Species
name: TSTA3
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_16c31155_4b88_46d4_9476_0156fca50d14
initial amount: NaN
name: MECR
type: Species
initial concentration: NaN
is encoded by: hsa:51102
is: Q9BV79
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR NDPK2n
fast: false
reversible: true
product: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reactant: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110004#_c6afeafd_2f01_4a92_95ed_8cbb3e2225fb
has only substance units: false
is encoded by: hsa:6240
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
name: RRM1
is: SBO:0000252
is: P23921
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_53450d2f_610a_40d9_8149_839f4eac30f6
type: Species
initial amount: NaN
is encoded by: hsa:4719
name: NDUFS1
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P28331
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_6ae02214_eb72_41b0_b2fb_d0ccf45087cf
is encoded by: hsa:594
initial concentration: NaN
is: SBO:0000252
type: Species
name: BCKDHB
initial amount: NaN
boundary condition: true
is: P21953
constant: false
has only substance units: false

metaR DM anth
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM ump n
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: UMP(2-)
type: Species
is: SBO:0000247
is: CHEBI:57865
constant: false
is: HMDB00288

metaR r2110
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110004#
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110004#
product: MODEL1310110004#

metaM ksi deg37 l
is: HMDB01354
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57455
name: keratan sulfate I, degradation product 37
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C62H104N4O46 CHARGE: 0

metaR RE3003M
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
name: RE3003
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
reversible: true
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/5.3.3.8
fast: false
is described by: ECO:0000000

metaM hs deg10 l
boundary condition: false
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
type: Species
is: CHEBI:15748
name: heparan sulfate, degradation product 10
is: HMDB00127
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM gmp c
initial concentration: 1.0
is: C00144
type: Species
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB01397
has only substance units: false
boundary condition: false
is: CHEBI:58115
name: GMP

metaR RE1796R
is version of: http://identifiers.org/ec-code/1.1.1.145
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
name: RE1796
is: SBO:0000176
product: MODEL1310110004#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
type: Reaction
modifier: MODEL1310110004#
is described by: ECO:0000000

metaM akg e
name: 2-oxoglutarate(2-)
constant: false
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
initial concentration: 1.0
is: HMDB00208
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:16810

metaR CGLYt3 2
type: Reaction
reversible: false
fast: false
modifier: MODEL1310110004#
name: Cys-Gly transport in via proton symport
is: SBO:0000185
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB
reactant: MODEL1310110004#

metaR FAOXC5OHc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_882ac5b8_0429_49c2_9528_a20b369c7d20
type: Species
name: _LOC374569_1_e
is encoded by: hsa:LOC374569
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR SEBACIDTD
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacic acid into cytosol (diffusion)
type: Reaction

metaM crtsl r
initial concentration: 1.0
is: CHEBI:17650
has only substance units: false
name: cortisol
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
boundary condition: false
notes: FORMULA: C21H30O5 CHARGE: 0 INCHI: InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00735
is: HMDB00063

metaM tethex3 c
has only substance units: false
initial concentration: 1.0
name: tetracosahexaenoic acid, n-3
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB02007
boundary condition: false
type: Species
notes: FORMULA: C24H35O2 CHARGE: -1 INCHI: InChI=1/C24H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-18H,2,5,8,11,14,19-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-,18-17-

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

metaR ACt2m
reactant: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
name: acetate mitochondrial transport via proton symport
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
is: SBO:0000185
product: MODEL1310110004#

metaM HC02210 e
boundary condition: false
name: prostaglandin-d3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
is: SBO:0000247
is: CHEBI:34939
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species

metaR ARSA
is: SBO:0000176
reversible: false
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (410.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.6.8 Confidence Level: 4 AUTHORS: PMID:2562955 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.6.8
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
fast: false
is described by: ECO:0000000
name: Arylsulfatase A

http://identifiers.org/biomodels.db/MODEL1310110004#_380b2b70_ba4c_40e2_a341_6791e8a2c953
initial amount: NaN
name: SLC16A10
initial concentration: NaN
constant: false
is encoded by: hsa:117247
boundary condition: true
is: SBO:0000252
type: Species
is: Q8TF71
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_g
is: HMDB00304
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
constant: false
name: Type IIIA glycolipid
initial concentration: 1.0
is: CHEBI:57847
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0

metaR DHCR241r
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
is version of: http://identifiers.org/ec-code/1.3.1.72
name: 24-dehydrocholesterol reductase [Precursor]
fast: false
product: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: false
modifier: MODEL1310110004#
is: SBO:0000176
type: Reaction

metaR DOCO13EFATP
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: absorption or uptake of 13-docosenoic acid into cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_260ad403_f5d3_4aa0_a1d9_82f31e5c099f
initial amount: NaN
type: Species
name: SCD
initial concentration: NaN
constant: false
is: O00767
is encoded by: hsa:6319
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR GALASE9ly
is described by: ECO:0000000
reactant: MODEL1310110004#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
type: Reaction
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110004#
is: SBO:0000176

metaM ak2lgchol hs c
initial amount: NaN
type: Species
is: C04317
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
initial concentration: 1.0
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
has only substance units: false
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/6975
is: SBO:0000247

metaM gmp e
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01397
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
has only substance units: false
is: CHEBI:58115
name: GMP(3-)
boundary condition: false

metaR GLYt7 311 r
product: MODEL1310110004#
reactant: MODEL1310110004#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
kinetic law: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
is: SBO:0000185
is described by: ECO:0000006

http://identifiers.org/biomodels.db/MODEL1310110004#_df8d788f_eea0_404b_b90d_eb94895b0844
type: Species
is: P21953
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
name: BCKDHB
constant: false
is encoded by: hsa:594
initial concentration: NaN

metaR r0680
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
reversible: true
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is version of: http://identifiers.org/ec-code/2.3.1.137
reactant: MODEL1310110004#
product: MODEL1310110004#

metaR r1788
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110004#
type: Reaction
is: SBO:0000185
product: MODEL1310110004#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false

metaM lneldccrn m
is: HMDB06461
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
name: Linoelaidyl carnitine
constant: false
type: Species
initial amount: NaN

metaM hs deg7 l
is: SBO:0000247
has only substance units: false
name: heparan sulfate, degradation product 7
initial concentration: 1.0
constant: false
is: HMDB01352
is: CHEBI:17180
boundary condition: false
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
type: Species
initial amount: NaN

metaR TCYNTt
reversible: false
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
product: MODEL1310110004#
name: Thiocyanate transport via diffusion (cytosol to extracellular)
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000

metaM elaid e
type: Species
initial concentration: 1.0
is: HMDB00573
constant: false
name: elaidate
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
is: CHEBI:30825

metaM 3octdece1crn c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C25H47NO5 CHARGE: 0
is: HMDB13336
name: 3-hydroxy-octadecenoyl carnitine
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR KSII CORE2tly
name: keratan sulfate II (core 2) transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110004#
fast: false
product: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000185
reactant: MODEL1310110004#

metaR FERO
reactant: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: (9843.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: Sareen S. Gropper, Jack L. Smith, James L. Groff (2009) Advanced nutrition and human metabolism, Wadsworth cengage learning, 5th edition, page 472-476. NOTES:
is: SBO:0000176
fast: false
name: ferroxidase
type: Reaction
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000134
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_e
has only substance units: false
is: CHEBI:15347
initial amount: NaN
is: HMDB01659
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
name: Type IIIA glycolipid
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_bfef5b17_d0f1_4657_85ec_f5265ba0ad89
has only substance units: false
constant: false
initial amount: NaN
is: P30048
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10935
name: PRDX3

metaR SPH1Pte
product: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000185
name: sph1p transport
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ

metaM ahcys m
initial concentration: 1.0
is: C00021
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00939
constant: false
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
type: Species
is: CHEBI:16680
name: S-Adenosyl-L-homocysteine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_1031484d_4097_4e70_87b2_15b4ce4d562c
name: ADSSL1
initial concentration: NaN
initial amount: NaN
is: Q8N142
is encoded by: hsa:122622
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

metaM ksi pre23 g
name: keratan sulfate I biosynthesis, precursor 23
boundary condition: false
is: SBO:0000247
is: CHEBI:28067
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR r1168
fast: false
is: SBO:0000176
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
name: EC:2.3.1.26
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
reactant: MODEL1310110004#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_ba183f08_2d10_4397_9c06_d721cdd39fb2
boundary condition: true
is encoded by: hsa:BC005314
name: _BC005314_1_x
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR CYTK1n
fast: false
kinetic law: MODEL1310110004#
name: cytidylate kinase (CMP),nuclear
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110004#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110004#_8f813313_6098_4b03_9b2b_f2ed66573206
is encoded by: hsa:AI640625
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: _AI640625_1_c
boundary condition: true
type: Species

metaR CHOLtu
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
modifier: MODEL1310110004#
product: MODEL1310110004#
reversible: true
is described by: ECO:0000269
name: Choline uniport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_9fcef76d_dbf6_4691_9fb9_03e58daaafeb
initial amount: NaN
boundary condition: true
is encoded by: hsa:10026
constant: false
type: Species
is: Q92643
name: PIGK
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaM dlnlcg e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: dihomo-gamma-linolenic acid (n-6)
type: Species
constant: false
has only substance units: false
is: HMDB02925
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
is: CHEBI:53486

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR EX ddecrn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_6901e43e_8887_45ae_a6b3_baa683d2708c
is: SBO:0000252
name: MAN2A2
is: Q9P1E4
is encoded by: hsa:4122
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_9182da5e_0f80_4c91_846b_4fd92865636d
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4724
boundary condition: true
constant: false
name: NDUFS4
is: O43181
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_6182f43a_618a_4e32_8709_cf126c1ebc3f
boundary condition: true
type: Species
is encoded by: hsa:10797
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: MTHFD2
constant: false
is: SBO:0000252
is: P13995

metaR RE1796M
reactant: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.145
kinetic law: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
name: RE1796
product: MODEL1310110004#

metaM ak2lgchol hs e
initial amount: NaN
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
is: C04317
is: http://identifiers.org/pubchem.compound/6975
constant: false
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

metaR RE1519M
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true
name: RE1519
is described by: ECO:0000000

metaR RE2625C
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
name: RE2625
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
type: Reaction
is: SBO:0000176
reversible: true

metaM 10fthf7glu e
initial amount: NaN
is: CHEBI:57454
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C50H57N13O25 CHARGE: -8
type: Species
name: 10-formyltetrahydrofolate-[Glu](7)
has only substance units: false
is: SBO:0000247
is: HMDB00972
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_af629031_7299_4029_a4d2_79f01a2d6a5a
name: AKR1A1
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:10327
constant: false
is: P14550
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_1f8e8fdb_1f01_4c11_b2fd_8a4beb97ee7b
has only substance units: false
is: Q969I6
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SLC38A4
is encoded by: hsa:55089
constant: false

metaM elaid c
is: CHEBI:30825
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1 INCHI: InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/p-1/b10-9+ HEPATONET_1.0_ABBREVIATION: HC00830
is: HMDB00573
constant: false
is: SBO:0000247
name: elaidate
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_8a05b781_6993_41e2_b4a5_b86b1a564de9
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:3158
name: HMGCS2
is: P54868
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_c
is: HMDB01659
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:15347
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
name: Type IIIA glycolipid

metaR GLCURter
reactant: MODEL1310110004#
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: glucuronate endoplasmic reticular transport
type: Reaction

metaM ru5p D r
is: HMDB00618
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
name: D-ribulose 5-phosphate(2-)
has only substance units: false
is: CHEBI:58121
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
constant: false

metaM 3octdece1crn e
is: HMDB13336
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: 3-hydroxy-octadecenoyl carnitine
initial amount: NaN
constant: false
notes: FORMULA: C25H47NO5 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110004#_0d0ee292_5477_4d28_a34b_4f58ab7709f0
constant: false
initial amount: NaN
is encoded by: hsa:AV727634
initial concentration: NaN
name: _AV727634_1_c
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaM btn e
initial amount: NaN
constant: false
type: Species
boundary condition: false
name: Biotin
is: C00120
is: SBO:0000247
is: CHEBI:3420
initial concentration: 1.0
notes: FORMULA: C10H15N2O3S CHARGE: -1
has only substance units: false
is: HMDB00030

metaM hedepecoa m
boundary condition: false
has only substance units: false
name: 2,4,7,10,13-hexadecapentenoylcoa
constant: false
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB02288

metaR ENGASE3ly
name: endo-beta-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110004#
is described by: ECO:0000000
product: MODEL1310110004#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110004#
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD

metaR THYMDtm
reversible: true
is: SBO:0000185
name: thymd transport
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:TDV
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
is described by: ECO:0000269
fast: false

metaR C10DCc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoylcarnitine
type: Reaction

metaM dlnlcg c
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
type: Species
initial amount: NaN
constant: false
name: dihomo-gamma-linolenic acid (n-6)
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:53486
boundary condition: false
is: HMDB02925
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_a3882cd3_ff49_424a_8fd3_e709fcb3ff99
is: Q308M7
is encoded by: hsa:5169
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
name: ENPP3
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_2b42fb6c_7e92_4298_838a_6719380d8bcf
is: O75874
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
name: IDH1
type: Species
is encoded by: hsa:3417

metaM leu L e
initial amount: NaN
name: L-leucine
initial concentration: 1.0
is: HMDB00687
is: CHEBI:15603
is: SBO:0000247
type: Species
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123

metaR r1010
product: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Postulated transport reaction
fast: false
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110004#
type: Reaction

metaR FAOXC142C122x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)x
type: Reaction

metaM ksi deg33 l
is: CHEBI:12936
type: Species
is: HMDB00143
boundary condition: false
notes: FORMULA: C76H125N5O62S2 CHARGE: -2
has only substance units: false
name: keratan sulfate I, degradation product 33
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0

metaM lnlncacrn m
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB06319
type: Species
name: alpha-linolenyl carnitine
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1

metaR CYTK1m
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
product: MODEL1310110004#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
name: cytidylate kinase (CMP),mitochondrial
reversible: true

metaR r1453
product: MODEL1310110004#
fast: false
is described by: ECO:0000000
reversible: true
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
type: Reaction
reactant: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_07ce7c6e_f60d_4b4d_9685_40900fb9f46d
is: SBO:0000252
initial amount: NaN
name: ACADVL
type: Species
is encoded by: hsa:37
constant: false
initial concentration: NaN
is: P49748
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_f8cbaac0_0902_4240_a83c_e088b5026710
constant: false
initial amount: NaN
name: PIGO
boundary condition: true
is: SBO:0000252
is encoded by: hsa:84720
has only substance units: false
initial concentration: NaN
type: Species

metaR SEBCOACROT
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of sebacoyl carnitine
type: Reaction

metaR PPAt
reactant: MODEL1310110004#
type: Reaction
fast: false
kinetic law: MODEL1310110004#
reversible: false
product: MODEL1310110004#
name: Propionate transport, diffusion
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV

metaM prostge1 e
type: Species
is: CHEBI:57397
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
has only substance units: false
boundary condition: false
name: prostaglandin E1(1-)
constant: false
is: HMDB01442

metaR HSD3A2r
type: Reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
reactant: MODEL1310110004#
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110004#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
kinetic law: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.225
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_c721bcc3_d7ce_4597_af5b_a3ec37bbade4
constant: false
initial amount: NaN
initial concentration: NaN
name: MTHFS
boundary condition: true
is: SBO:0000252
type: Species
is: P49914
is encoded by: hsa:10588
has only substance units: false

metaR AG13T18g
fast: false
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110004#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
reversible: false

metaM HC01406 m
is: CHEBI:28264
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: 3-Oxooctanoyl-CoA
constant: false

metaR r2525
reversible: true
type: Reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110004#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR r2311
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110004#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110004#
product: MODEL1310110004#

metaM m1mpdol U c
boundary condition: false
has only substance units: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
is: CHEBI:28067
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: SBO:0000247

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_a5f5f239_5df3_40e3_8a5f_ea5483ef135e
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
name: PROSC
is encoded by: hsa:11212
boundary condition: true
is: O94903
constant: false

metaM cholcoaone x
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:58507
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
is: HMDB06891

metaM tettet6coa x
name: tetracosatetraenoyl coenzyme A
type: Species
constant: false
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205481
is: HMDB06516
is: C16171
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_c6be3f60_94b4_4d1a_a150_9fdd7f69037b
initial amount: NaN
is encoded by: hsa:65985
constant: false
is: Q86V21
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: AACS

metaM 5pmev x
initial amount: NaN
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00670 EHMN_ABBREVIATION: C01107
type: Species
initial concentration: 1.0
is: CHEBI:58146
is: HMDB01343
is: SBO:0000247
constant: false
boundary condition: false
name: (R)-5-phosphonatomevalonate(3-)
has only substance units: false

metaR r1892
product: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110004#
reversible: false
reactant: MODEL1310110004#

metaR r2119
modifier: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
reversible: true
fast: false
kinetic law: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110004#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR GASNASE2ly
is version of: http://identifiers.org/ec-code/3.5.1.26
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110004#
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
name: glycosylasparaginase, lysosomal
product: MODEL1310110004#
reactant: MODEL1310110004#
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_2e4b0407_ad0d_4bfd_a12b_773a0df59c36
type: Species
name: PNPLA3
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:80339
is: SBO:0000252
is: Q9NST1

metaR r0974
product: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
fast: false
name: Active transport
type: Reaction
kinetic law: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110004#

metaR FAOXC165C164m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaR URIK1
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
reactant: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
is: SBO:0000176
fast: false
reversible: false
name: uridine kinase (ATP:Uridine)
is version of: http://identifiers.org/ec-code/2.7.1.48
is described by: ECO:0000269
modifier: MODEL1310110004#

metaR GALASE19ly
fast: false
is described by: ECO:0000269
reversible: false
product: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110004#
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR G12MT1 U
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#

metaR r2310
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110004#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
reversible: true
kinetic law: MODEL1310110004#

metaR r2118
product: MODEL1310110004#
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110004#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR ADEt
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000269
reversible: true
name: adenine reversible transport, cytosol
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
type: Reaction
reactant: MODEL1310110004#
fast: false
is: SBO:0000185
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_69493274_27ff_4ce3_9dee_e02cb044f034
is: SBO:0000252
has only substance units: false
boundary condition: true
name: _AI222095_1_m
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:AI222095
initial concentration: NaN

metaR G14T20g
type: Reaction
product: MODEL1310110004#
modifier: MODEL1310110004#
reactant: MODEL1310110004#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
fast: false
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD

metaR r0236
reactant: MODEL1310110004#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.6
type: Reaction
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
kinetic law: MODEL1310110004#
fast: false
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_e4170f52_1e44_4aa6_8edf_9f949bfdc5a3
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:53354
constant: false
initial concentration: NaN
initial amount: NaN
name: PANK1

http://identifiers.org/biomodels.db/MODEL1310110004#_5db622d7_978a_4647_992b_b46ed3647049
is: B1AM93
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:4702
type: Species
name: NDUFA8
is: SBO:0000252

metaR URCN
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.49
name: URCN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
reversible: false
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_d1f09d01_9dc7_48df_880a_e5c28bc29380
name: _BE042354_1_m
is encoded by: hsa:BE042354
boundary condition: true
type: Species
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR PCt
is version of: http://identifiers.org/ec-code/3.6.3.44
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110004#
is: SBO:0000185
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
product: MODEL1310110004#
name: phosphatidylcholine transporter
reactant: MODEL1310110004#
fast: false

metaR r2313
product: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110004#
type: Reaction
reversible: true
is: SBO:0000185

metaM prostge1 c
constant: false
is: HMDB01442
type: Species
is: CHEBI:57397
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
has only substance units: false
name: prostaglandin E1(1-)
initial amount: NaN
boundary condition: false

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaR FAOXC205C185m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaM dcsptn1 c
constant: false
is: http://identifiers.org/pubchem.compound/5282848
has only substance units: false
initial concentration: 1.0
is: HMDB13123
name: docosa-4,7,10,13,16-pentaenoic acid
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-

http://identifiers.org/biomodels.db/MODEL1310110004#_47520ef7_c849_488e_8a96_716fc53e49c3
is encoded by: hsa:80864
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: EGFL8
type: Species
is: Q99944
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_ce9541a7_d281_4f6c_8a67_6e6b73d40b2b
name: AKR1D1
is encoded by: hsa:6718
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: P51857

metaR B3GNT34g
is: SBO:0000176
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
type: Reaction
fast: false
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000269
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaR r2117
kinetic law: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
is described by: ECO:0000000
reversible: true
product: MODEL1310110004#
fast: false

metaM ptdca c
is: HMDB00826
type: Species
name: pentadecanoate
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/22169126
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)

http://identifiers.org/biomodels.db/MODEL1310110004#_39db7684_618d_4982_aace_5d7dfb7a512f
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3423
initial amount: NaN
is: B4DGD7
initial concentration: NaN
constant: false
boundary condition: true
name: IDS

http://identifiers.org/biomodels.db/MODEL1310110004#_b5f849ef_fded_48f4_8618_42bcb4be94ef
boundary condition: true
name: ARSA
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:410
is: SBO:0000252
is: P15289
constant: false
initial amount: NaN

metaR CHOLtn
is: SBO:0000185
name: Choline transport, nuclear through pores
reactant: MODEL1310110004#
reversible: true
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it

http://identifiers.org/biomodels.db/MODEL1310110004#_6ea51295_9f15_4e86_9f36_a7146a9d14ba
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
name: VNN2
is encoded by: hsa:8875
has only substance units: false
is: A8K7W0
type: Species
initial amount: NaN

metaM pydx5p c
is: C00018
is: CHEBI:597326
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
has only substance units: false
is: HMDB01491
constant: false
name: Pyridoxal 5'-phosphate
initial amount: NaN

metaM akg m
constant: false
boundary condition: false
initial concentration: 1.0
is: C00026
is: CHEBI:16810
is: HMDB00208
has only substance units: false
initial amount: NaN
name: 2-Oxoglutarate
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
is: SBO:0000247
type: Species

metaM ksi deg18 l
is: SBO:0000247
notes: FORMULA: C146H235N10O127S7 CHARGE: -7
type: Species
initial concentration: 1.0
constant: false
name: keratan sulfate I, degradation product 18
boundary condition: false
is: CHEBI:12936
is: HMDB00143
initial amount: NaN
has only substance units: false

metaR r2312
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true

metaM ksi pre12 g
is: SBO:0000247
is: CHEBI:58053
is: HMDB00175
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
name: keratan sulfate I biosynthesis, precursor 12
constant: false
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: C00130

metaM tetpent6coa c
initial amount: NaN
initial concentration: 1.0
is: C16172
name: tetracosapentaenoyl coenzyme A, n-6
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
type: Species
boundary condition: false

metaR r2116
product: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110004#

metaR r0973
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110004#
is: SBO:0000185
name: Facilitated diffusion
reactant: MODEL1310110004#
product: MODEL1310110004#
type: Reaction

metaR r2526
kinetic law: MODEL1310110004#
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110004#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110004#
type: Reaction

metaR FUMm
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000134
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.2
name: fumarase, mitochondrial
fast: false
modifier: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
kinetic law: MODEL1310110004#
type: Reaction

metaR r2115
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110004#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
reversible: true
fast: false

metaR CITL
name: Citrate lyase
is described by: ECO:0000000
reactant: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
fast: false
is: SBO:0000176
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_2d66bb64_8879_4380_967f_4c6b85cdf9fb
initial amount: NaN
initial concentration: NaN
name: HMGCS1
is encoded by: hsa:3157
type: Species
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252

metaR ACACt2m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110004#
type: Reaction
is: SBO:0000185
fast: false
name: Acetoacetate mitochondrial transport via H+ symport
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
modifier: MODEL1310110004#

metaM dcsptn1 e
boundary condition: false
is: http://identifiers.org/pubchem.compound/5282848
type: Species
is: HMDB13123
has only substance units: false
name: docosa-4,7,10,13,16-pentaenoic acid
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C22H33O2 CHARGE: -1 INCHI: InChI=1/C22H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16,18-19H,2-5,8,11,14,17,20-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-,19-18-
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_1f65e27e_58b4_4d85_b2c8_8c69e17b1d92
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is: O95861
name: BPNT1
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10380

metaR r2521
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
type: Reaction
name: Utilized transport
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110004#
fast: false

metaR C161OHc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyhexadecenoylcarnitine
type: Reaction

metaM maltpt e
is: HMDB01296
constant: false
boundary condition: false
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
has only substance units: false
name: maltopentaose
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C02052
is: http://identifiers.org/pubchem.compound/5141

metaR HPYRRy
fast: false
product: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:2689175,PMID:9038835 NOTES:JLR
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110004#
name: Hydroxypyruvate reductase (NADPH)
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.79
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_4402dbff_2274_4a99_bc3f_3c3fae793d2d
initial concentration: NaN
is encoded by: hsa:23517
initial amount: NaN
has only substance units: false
is: Q3MHC9
is: SBO:0000252
constant: false
name: SKIV2L2
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_6605d820_9b20_436a_b9df_c997d96c5174
has only substance units: false
initial concentration: NaN
name: CHST6
boundary condition: true
type: Species
constant: false
is encoded by: hsa:4166
is: SBO:0000252
initial amount: NaN
is: Q9GZX3

metaM gmp g
name: GMP(3-)
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:58115
is: HMDB01397
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaR HOXG
modifier: MODEL1310110004#
name: Heme oxygenase 1
is described by: ECO:0000134
product: MODEL1310110004#
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.14.99.3
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_98cff21a_042a_44ba_81d7_a486d235b5fb
type: Species
is encoded by: hsa:4713
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: NDUFB7
is: P17568
has only substance units: false

metaM ksi pre24 g
is: SBO:0000247
is: HMDB00175
initial amount: NaN
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
name: keratan sulfate I biosynthesis, precursor 24
is: C00130
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:58053

metaM HC02175 e
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:27689
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: caprate

metaR r2114
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
reversible: true

metaR FAOXC14C12m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_3c7ceda7_3aee_4a54_ab91_e5b1b7fc7cfb
boundary condition: true
name: ATP5H
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10476
is: O75947
has only substance units: false
initial amount: NaN
type: Species

metaR NDPK6n
is described by: ECO:0000304
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_ab6533a6_fdac_4bb5_b813_c029f33926bd
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: _728226_1_m
initial concentration: NaN
is encoded by: hsa:728226
has only substance units: false

metaR DNDPt11m
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
fast: false
modifier: MODEL1310110004#
reversible: false
name: dADP transport via dGDP antiport
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000269
is: SBO:0000185
type: Reaction

metaM ump r
has only substance units: false
type: Species
is: CHEBI:57865
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
name: UMP
is: HMDB00288
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105

http://identifiers.org/biomodels.db/MODEL1310110004#_2886fbf8_2b3e_4bf4_83b9_1cd27ff6dd25
has only substance units: false
has part: Q6IB04
type: Species
is: SBO:0000297
boundary condition: true
is encoded by: hsa:84720
name: PIGF:PIGO
constant: false
is encoded by: hsa:5281
initial amount: NaN
initial concentration: NaN

metaM sphings c
name: sphingosine(1+)
boundary condition: false
is: CHEBI:57756
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
initial concentration: 1.0
is: HMDB00252

http://identifiers.org/biomodels.db/MODEL1310110004#_e5fef0c7_fd10_44cd_8e24_9fa31e05cf2a
name: SLC13A1
boundary condition: true
is: Q9BZW2
initial concentration: NaN
is encoded by: hsa:6561
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252

metaM 3tetd7ecoa c
is: HMDB05066
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
name: 3-hydroxy tetradecenoyl-7-coa
is: SBO:0000247
initial concentration: 1.0
type: Species

metaM hLkynr c
initial concentration: 1.0
is: CHEBI:17380
is: HMDB11631
type: Species
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
initial amount: NaN
boundary condition: false
name: 3-hydroxy-L-kynurenine
has only substance units: false
is: SBO:0000247
constant: false

metaR SIAT9g
is version of: http://identifiers.org/ec-code/2.4.99.9
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110004#
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110004#
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
reactant: MODEL1310110004#
product: MODEL1310110004#
reversible: false

metaR r2113
reversible: true
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110004#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000

metaR r1017
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12663868,PMID:14716480,PMID:15209530,PMID:15297262,PMID:1599411,PMID:17416343,PMID:9068608 NOTES:
reversible: false
kinetic law: MODEL1310110004#
name: Vesicular transport
reactant: MODEL1310110004#
is: SBO:0000185
fast: false
is described by: ECO:0000000
product: MODEL1310110004#
type: Reaction

metaR S6T15g
is version of: http://identifiers.org/ec-code/2.8.2.21
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.17
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110004#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_58299c78_d1bd_497b_8ef8_874e7c6d056a
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: _PRO1933_1_m
is encoded by: hsa:PRO1933
boundary condition: true
has only substance units: false
constant: false
type: Species

metaR NDPK6m
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
is described by: ECO:0000254
fast: false
kinetic law: MODEL1310110004#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110004#
modifier: MODEL1310110004#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110004#

metaR NACHEX24ly
reactant: MODEL1310110004#
modifier: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176

metaR S6TASE14ly
product: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.14
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
kinetic law: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110004#

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaR BMTer U
is described by: ECO:0000000
product: MODEL1310110004#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
name: B mannosyltransferase, endoplasmic reticulum
is: SBO:0000176
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#

metaM n2m2nmn l
is: CHEBI:17588
boundary condition: false
initial concentration: 1.0
type: Species
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
is: HMDB00742
notes: FORMULA: C50H84N4O36 CHARGE: 0
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_860846dd_d302_4f45_b82a_234dddaa1d0a
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: E9PEI9
initial concentration: NaN
name: LSS
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4047

metaR DUTPDPn
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
type: Reaction
is described by: ECO:0000269
name: dUTP diphosphatase, nuclear
fast: false
kinetic law: MODEL1310110004#
reversible: false
is: SBO:0000176
modifier: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.6.1.23
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_37a11222_5e64_45e8_983d_f5b9ad5282ad
is encoded by: hsa:1491
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
name: CTH
is: SBO:0000252
initial amount: NaN
type: Species
is: P32929

metaR CYANtm
is: SBO:0000185
product: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
name: Cyanide transport via diffusion (mitochondrial)
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_a56701ab_b2d6_452d_ae40_a9fbd7415199
name: SLC9A3
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: P48764
is: SBO:0000252
is encoded by: hsa:6550
initial amount: NaN
has only substance units: false

metaM c4dc c
type: Species
has only substance units: false
notes: FORMULA: C11H18NO6 CHARGE: -1
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: C02862
is: HMDB02013
name: succinyl carnitine
is: http://identifiers.org/pubchem.compound/213144
is: SBO:0000247

metaR sink octdececoa LPAREN c RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: OCTDECECOASINK
type: Reaction

metaR r2112
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR PRO Dtde
is: SBO:0000185
name: D-proline transport, extracellular
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110004#
type: Reaction

metaR PSDm hs
kinetic law: MODEL1310110004#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.65
reactant: MODEL1310110004#
product: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: Phosphatidylserine decarboxylase

metaR r1018
is: SBO:0000185
fast: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110004#
type: Reaction
name: Transport reaction
reactant: MODEL1310110004#

metaR FUT910g
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.152
is: SBO:0000176
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000269
reversible: false
name: Alpha-(1,3)-fucosyltransferase
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ

metaR ADCim
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
name: Acetoacetate decarboxylation (irreversible), mitochondrial
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
fast: false

metaM leu L m
type: Species
is: HMDB00687
constant: false
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial amount: NaN
is: SBO:0000247
name: L-leucine
initial concentration: 1.0
is: CHEBI:15603
boundary condition: false

metaR CYTK11n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
name: cytidylate kinase (dCMP,dGTP),nuclear
is described by: ECO:0000269
fast: false
product: MODEL1310110004#

metaM hdd2coa x
has only substance units: false
name: (E)-hexadec-2-enoyl-CoA(4-)
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: CHEBI:61526
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB03945
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_14340dbe_eb7e_4eb5_98c0_0feaa9f00c59
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is: E9KL42
has only substance units: false
is encoded by: hsa:641371
initial amount: NaN
is: SBO:0000252
name: ACOT1

http://identifiers.org/biomodels.db/MODEL1310110004#_f9a430c0_6052_4286_83a3_ce4a7b1ae70c
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:217
name: ALDH2
type: Species
constant: false
is: P05091
initial amount: NaN

metaR r1912
product: MODEL1310110004#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR C6DCc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of adipoylcarnitine
type: Reaction

metaM 4nph c
is: CHEBI:57917
initial amount: NaN
is: HMDB01232
type: Species
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
boundary condition: false
constant: false
has only substance units: false
name: 4-nitrophenolate
initial concentration: 1.0
is: SBO:0000247

metaR DUTPDPm
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
modifier: MODEL1310110004#
is: SBO:0000176
fast: false
is described by: ECO:0000269
reactant: MODEL1310110004#
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.23
name: dUTP diphosphatase

metaR FUM
name: fumarase
product: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.2
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#

metaR BDMT U
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
modifier: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
reversible: false
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.142

metaM pail35p hs c
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
constant: false
is: CHEBI:57923
initial concentration: 1.0
type: Species

metaR r1008
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is: SBO:0000185
name: Facilitated diffusion
kinetic law: MODEL1310110004#
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110004#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_c94d7486_cc46_4116_85ea_e8db824d7662
initial concentration: NaN
is encoded by: hsa:11000
is: Q5K4L6
name: SLC27A3
constant: false
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN

metaR r0389
reversible: true
is: SBO:0000176
reactant: MODEL1310110004#
fast: false
is described by: ECO:0000000
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.1.3.12 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
name: Pyridoxine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.1.3.12

http://identifiers.org/biomodels.db/MODEL1310110004#_6b73b419_09e7_40d2_8a23_a265f0746398
is encoded by: hsa:3155
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: HMGCL
boundary condition: true
is: Q6IBC0

metaR EX c101crn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decenoyl carnitine
type: Reaction

metaR EX pheme LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for heme
type: Reaction

metaM ksi deg22 l
notes: FORMULA: C132H214N9O111S5 CHARGE: -5
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57455
is: HMDB01354
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: keratan sulfate I, degradation product 22

http://identifiers.org/biomodels.db/MODEL1310110004#_f3a086c4_b4e2_45ec_9e24_118be4415d0f
is: SBO:0000252
initial concentration: NaN
name: ATP1B2
constant: false
is encoded by: hsa:482
is: P14415
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN

metaR S6TASE10ly
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110004#
is described by: ECO:0000000
name: galactose-6-sulfate sulfatase, lysosomal
is: SBO:0000176
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_053bbae2_bbb4_427c_922d_73c96c5a3db1
name: PLD1
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is: Q59EA4
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5337
type: Species

metaR DOLPMT4 Uer
is: SBO:0000185
kinetic law: MODEL1310110004#
is described by: ECO:0000000
reactant: MODEL1310110004#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
fast: false
product: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_5da89d59_d7da_477b_aa8e_26f6dc9b01bf
initial concentration: NaN
is encoded by: hsa:5286
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is: O00443
name: PIK3C2A
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_a1492d95_b820_4e30_b9b4_f6936e3e99bf
type: Species
initial concentration: NaN
is encoded by: hsa:8503
has part: Q92569
is encoded by: hsa:5293
initial amount: NaN
has part: A7E2E0
name: PIK3CD:PIK3R3
has only substance units: false
is: SBO:0000297
boundary condition: true
constant: false

metaR FRDPtcr
reversible: true
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_ef5f3b58_f2f4_4f6f_b257_e0795b1f22e6
is encoded by: hsa:517
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: ATP5G2
constant: false
boundary condition: true
initial concentration: NaN
is: Q06055

metaR AMETtd
reactant: MODEL1310110004#
name: diffusion of S-Adenosyl-L-methionine
reversible: true
type: Reaction
kinetic law: MODEL1310110004#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110004#
is described by: ECO:0000134

metaM 3dodtricoa m
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
constant: false
boundary condition: false
is: C05279
initial concentration: 1.0
name: 3,6,9-dodecatrienoylcoa
has only substance units: false
is: HMDB11123
type: Species

metaR r0388
product: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 0 AUTHORS: PMID:6088736,PMID:9601034 NOTES:
is described by: ECO:0000000
name: Pyridoxamine:oxygen oxidoreductase (deaminating) Vitamin B6 metabolism EC:1.4.3.5
reactant: MODEL1310110004#
fast: false
type: Reaction

metaR URAt
reversible: true
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
modifier: MODEL1310110004#
is described by: ECO:0000269
name: uracil transport via facilated diffusion
reactant: MODEL1310110004#
fast: false
is: SBO:0000185
product: MODEL1310110004#

metaM ksii core4 deg3 l
is: HMDB00143
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: keratan sulfate II (core 4-linked), degradation product 3
initial amount: NaN
is: CHEBI:12936
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
type: Species
boundary condition: false

metaM leugly c
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
name: Leucylglycine
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/97364
initial amount: NaN
type: Species
notes: FORMULA: C8H16N2O3 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110004#_9be3b827_53e8_4297_9644_d9d9a513cfa7
is: SBO:0000252
has only substance units: false
name: _AF116616_1_m
boundary condition: true
constant: false
is encoded by: hsa:AF116616
initial amount: NaN
initial concentration: NaN
type: Species

metaM 4nph e
is: HMDB01232
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57917
type: Species
constant: false
name: 4-nitrophenolate
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870

http://identifiers.org/biomodels.db/MODEL1310110004#_ca6c6e98_b38c_4220_8977_60e80158af86
is: SBO:0000252
name: RHBG
initial amount: NaN
type: Species
boundary condition: true
is: Q9H310
has only substance units: false
is encoded by: hsa:57127
initial concentration: NaN
constant: false

metaR EX 3hdececrn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxyhexadecenoyl carnitine
type: Reaction

metaR r2308
is: SBO:0000185
type: Reaction
reactant: MODEL1310110004#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
is described by: ECO:0000000
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reversible: true

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

metaM g3m8mpdol U r
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: C05873
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
boundary condition: false

metaR CDPDAGtm
name: intracellular transport
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110004#
fast: false
is described by: ECO:0000000

metaR PPAm
is version of: http://identifiers.org/ec-code/3.6.1.1
name: inorganic diphosphatase
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
modifier: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110004#
type: Reaction
is described by: ECO:0000269
reversible: false

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaM ahcys c
is: SBO:0000247
is: CHEBI:16680
has only substance units: false
is: C00021
boundary condition: false
initial amount: NaN
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
is: HMDB00939
initial concentration: 1.0
constant: false
name: S-Adenosyl-L-homocysteine
type: Species

metaR r2309
is: SBO:0000185
reactant: MODEL1310110004#
fast: false
product: MODEL1310110004#
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000

metaR r0386
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
product: MODEL1310110004#
fast: false
is: SBO:0000176
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
name: 4-methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
is described by: ECO:0000000
reversible: false

metaR GALASE8ly
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
fast: false
reversible: false
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.4.16.5
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.18

metaR CHTNASEe
is version of: http://identifiers.org/ec-code/3.2.1.14
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (27159.2) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.14 Confidence Level: 4 AUTHORS: PMID:11085997 NOTES:NCD
modifier: MODEL1310110004#
name: chitinase, extracellular
kinetic law: MODEL1310110004#
is: SBO:0000176
fast: false
reactant: MODEL1310110004#
is described by: ECO:0000269
product: MODEL1310110004#

metaR RNDR1
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110004#
product: MODEL1310110004#
reversible: false
fast: false
kinetic law: MODEL1310110004#
is described by: ECO:0000254
name: ribonucleoside-diphosphate reductase (ADP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
type: Reaction

metaM 56dura c
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:15901
name: 5,6-dihydrouracil
has only substance units: false
initial amount: NaN
is: HMDB00076
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_fcc0fd57_7c3e_48f6_9005_852112cf58d9
name: HAO1
has only substance units: false
is: Q9UJM8
is: SBO:0000252
constant: false
is encoded by: hsa:54363
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

metaR GALASE20ly
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
modifier: MODEL1310110004#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110004#
type: Reaction

metaR RE3520E
type: Reaction
reversible: true
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.9
reactant: MODEL1310110004#
product: MODEL1310110004#
name: RE3520
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
fast: false

metaR PSFLIPm
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/3.6.3.1
name: phosphatidylserine flippase
product: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reversible: false
reactant: MODEL1310110004#

metaR ADSL1
fast: false
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/4.3.2.2
kinetic law: MODEL1310110004#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
reactant: MODEL1310110004#
is: SBO:0000176
reversible: false
name: adenylosuccinate lyase
modifier: MODEL1310110004#

metaM arachd e
is: HMDB01043
is: CHEBI:32395
name: arachidonate
has only substance units: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaM mi1p D n
type: Species
is: CHEBI:58433
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB02985
name: 1D-myo-inositol 1-phosphate(2-)
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698

metaR r0385
is: SBO:0000176
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110004#
type: Reaction
fast: false
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_5f4cdbb4_27f0_4d94_91d1_ec212e50a98a
has only substance units: false
name: SLC25A16
is: P16260
is: SBO:0000252
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:8034
initial concentration: NaN

metaM ru5p D c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
boundary condition: false
type: Species
is: CHEBI:58121
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00618
name: D-ribulose 5-phosphate(2-)

metaM ptdca e
is: SBO:0000247
constant: false
is: HMDB00826
name: pentadecanoate
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/22169126
initial concentration: 1.0
notes: FORMULA: C15H29O2 CHARGE: -1 INCHI: InChI=1/C15H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15(16)17/h2-14H2,1H3,(H,16,17)
initial amount: NaN
has only substance units: false

metaM arachd c
is: SBO:0000247
type: Species
constant: false
has only substance units: false
is: CHEBI:32395
initial amount: NaN
name: arachidonate
is: HMDB01043
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
boundary condition: false

metaR GNDer
type: Reaction
name: phosphogluconate dehydrogenase, endoplasmic reticulum
is: SBO:0000176
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
is described by: ECO:0000000
reversible: false
product: MODEL1310110004#
fast: false

metaR S3TASE2ly
reversible: true
fast: false
name: N-acetylglucosamine-3-sulfatase, lysosomal
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#

metaR DCMPDA
kinetic law: MODEL1310110004#
name: dCMP deaminase
product: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/3.5.4.12
fast: false
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110004#
type: Reaction

metaR ADSL2
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110004#
kinetic law: MODEL1310110004#
name: adenylosuccinate lyase
modifier: MODEL1310110004#
is described by: ECO:0000269
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/4.3.2.2
type: Reaction
reversible: false

metaM hdd2coa m
has only substance units: false
name: trans-Hexadec-2-enoyl-CoA
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: C05272
is: HMDB03945
constant: false
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: CHEBI:61526

metaR r0384
reversible: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
is described by: ECO:0000000
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
product: MODEL1310110004#

metaM 3tetd7ecoa m
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB05066
constant: false
name: 3-hydroxy tetradecenoyl-7-coa
initial concentration: 1.0
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_2e10fb25_4387_4afd_8d56_cc34f3f9521d
boundary condition: true
type: Species
name: IDH3G
is encoded by: hsa:3421
is: E9PDD5
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN

metaR r2108
kinetic law: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110004#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110004#

metaR RNDR4
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
is described by: ECO:0000254
modifier: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110004#
type: Reaction
name: ribonucleoside-diphosphate reductase (UDP)
fast: false

metaR r0242
product: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
is: SBO:0000176
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.1
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
type: Reaction
reactant: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:

metaR FAOXC5C5DCc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_be44fc94_1895_4018_864c_5625f7039447
constant: false
name: ACSS3
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:79611
is: Q9H6R3

http://identifiers.org/biomodels.db/MODEL1310110004#_8914f92e_fd1d_4ce4_88d2_33925b4ada9c
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5152
name: PDE9A

http://identifiers.org/biomodels.db/MODEL1310110004#_29079a76_ac14_4916_bc2c_9a94e90d19ad
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:54539
name: NDUFB11
type: Species
is: Q9NX14
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN

metaR MALSO3tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
product: MODEL1310110004#
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reversible: true
name: Malate:sulfite antiport, mitochondrial
reactant: MODEL1310110004#

metaR NACHEX11ly
kinetic law: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
reactant: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
fast: false
modifier: MODEL1310110004#

metaR r0679
fast: false
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
reactant: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33

metaR FAEL183
is: SBO:0000176
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
product: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
name: fatty-acyl-CoA elongation (n-C18:3CoA)

http://identifiers.org/biomodels.db/MODEL1310110004#_4149e3bd_4cc4_4258_92f6_570aca053b9a
initial amount: NaN
constant: false
name: CHAT
boundary condition: true
has only substance units: false
is: Q6LEN6
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1103

metaR C142ACBP
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradeca dienoyl coa from mitochondria into cytosol
type: Reaction

metaR r2109
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110004#
modifier: MODEL1310110004#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaR RNDR3
kinetic law: MODEL1310110004#
is described by: ECO:0000269
reactant: MODEL1310110004#
reversible: false
product: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000176
name: ribonucleoside-diphosphate reductase (CDP)
fast: false
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction

metaM ksi deg32 l
is: CHEBI:12936
notes: FORMULA: C82H135N5O67S2 CHARGE: -2
has only substance units: false
initial amount: NaN
name: keratan sulfate I, degradation product 32
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00143

metaM leugly e
constant: false
boundary condition: false
is: SBO:0000247
type: Species
name: Leucylglycine
is: http://identifiers.org/pubchem.compound/97364
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H16N2O3 CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_f4a78d5d_f12a_4e53_b986_b65d8058ec2d
type: Species
initial amount: NaN
name: GNS
initial concentration: NaN
is: Q7Z3X3
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2799
constant: false

metaM ksii core2 pre7 g
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: C00130
notes: FORMULA: C67H108N5O51SX CHARGE: -2
is: CHEBI:58053
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 7

http://identifiers.org/biomodels.db/MODEL1310110004#_887de2d2_7b7f_4810_93cc_e981bfc9e4bb
boundary condition: true
constant: false
name: ALDH3A1
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:218
is: SBO:0000252
initial concentration: NaN
is: P30838

http://identifiers.org/biomodels.db/MODEL1310110004#_b1b785c3_655e_44da_a237_b85c23ed6932
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
name: AMACR
boundary condition: true
is: Q3KT79
is encoded by: hsa:23600
has only substance units: false

metaM tethex3coa c
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205478
is: C16168
notes: FORMULA: C45H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4,7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38?,39-,40+,44-/m1/s1
name: tetracosahexaenoyl coenzyme A
is: HMDB06243
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species

metaM kynate c
is: HMDB00715
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
name: kynurenate
has only substance units: false
boundary condition: false
is: CHEBI:58454

metaM ksi deg11 l
name: keratan sulfate I, degradation product 11
constant: false
type: Species
is: HMDB00143
is: CHEBI:12936
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C180H289N12O158S9 CHARGE: -9

metaR r0381
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
is: SBO:0000176
fast: false
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
reversible: true
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
kinetic law: MODEL1310110004#
type: Reaction

metaR 34HPPOR
product: MODEL1310110004#
is described by: ECO:0000269
modifier: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/1.13.11.27
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

metaR FACOAL80i
reactant: MODEL1310110004#
name: fatty-acid--CoA ligase (octanoate)
product: MODEL1310110004#
modifier: MODEL1310110004#
reversible: false
kinetic law: MODEL1310110004#
is described by: ECO:0000269
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3

metaR NADPHtxu
reversible: false
type: Reaction
is: SBO:0000185
product: MODEL1310110004#
name: NADPH transporter, peroxisome
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
fast: false

metaM zym int2 r
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:52386
name: zymosterol intermediate 2
constant: false
initial amount: NaN

metaM oagd3 hs c
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: HMDB00286
type: Species
has only substance units: false
name: 9-O-Acetylated GD3
initial amount: NaN
is: C00029
is: CHEBI:58367

http://identifiers.org/biomodels.db/MODEL1310110004#_699d7b15_6eaf_4bab_b2a6_418db1afdd95
name: ODC1
constant: false
is encoded by: hsa:4953
initial amount: NaN
boundary condition: true
is: P11926
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_2a8033f1_919b_487b_b323_22c0cd7544a3
type: Species
initial amount: NaN
is encoded by: hsa:5149
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: Q13956
name: PDE6H

http://identifiers.org/biomodels.db/MODEL1310110004#_c6ddfdaa_7236_47ca_8e76_7ba538445a8d
boundary condition: true
constant: false
is encoded by: hsa:6817
initial concentration: NaN
type: Species
name: SULT1A1
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_147a746b_2f29_4683_97ec_c1b66d421eba
has only substance units: false
is encoded by: hsa:6818
initial concentration: NaN
constant: false
name: SULT1A3
type: Species
is: P50224
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR FAOXC9C7m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

metaM retn r
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
name: all-trans-retinoate
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false
is: HMDB01852
is: CHEBI:35291

metaM ump e
type: Species
is: CHEBI:57865
constant: false
initial concentration: 1.0
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00288

metaM paf hs c
is: CHEBI:36707
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
initial amount: NaN
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_de34eb44_7f60_4cc1_96f4_1efa8378d267
is: F5GY65
name: SLC25A11
type: Species
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:8402

metaR FAOXC16180m
reversible: false
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox, 1 loss of degree of unsat -> only 3 fad oxidized c16:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.99.3
name: Beta oxidation fatty acid

metaM xol7ah3 m
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB12455
boundary condition: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
has only substance units: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
type: Species
is: CHEBI:28540

http://identifiers.org/biomodels.db/MODEL1310110004#_0b088d4d_5ce8_4e54_a2bd_5ad57f01f27f
is: SBO:0000252
type: Species
is encoded by: hsa:AI971036
constant: false
boundary condition: true
name: _AI971036_1_x
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR S6TASE25ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
name: galactose-6-sulfate sulfatase, lysosomal
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110004#
reversible: true
is: SBO:0000176
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction

metaM hs deg17 l
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:21338
is: SBO:0000247
type: Species
name: heparan sulfate, degradation product 17
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
is: HMDB02704
has only substance units: false
initial concentration: 1.0

metaM g3m8masn r
is: SBO:0000247
constant: false
is: C05873
boundary condition: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
notes: FORMULA: C88H147N2O70X CHARGE: 0
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR r0523
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
fast: false
kinetic law: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110004#
reversible: false
product: MODEL1310110004#
type: Reaction
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2

http://identifiers.org/biomodels.db/MODEL1310110004#_d8b116c2_8ab6_4982_9a02_98a0b274cbfd
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:3421
name: IDH3G
is: P51553
initial amount: NaN
constant: false

metaM abt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: CHEBI:18403
is: SBO:0000247
type: Species
is: HMDB01851
initial amount: NaN
name: L-arabinitol
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaM 3pg m
is: SBO:0000247
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
is: HMDB00807
initial concentration: 1.0
type: Species
is: CHEBI:58272
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate

metaR CBASPte
reactant: MODEL1310110004#
reversible: true
is: SBO:0000185
name: Transport of N-carbamoyl-L-aspartate
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000134
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM c81crn e
notes: FORMULA: C15H27NO4 CHARGE: 0
is: SBO:0000247
type: Species
is: HMDB13324
initial amount: NaN
constant: false
boundary condition: false
name: octenoyl carnitine
initial concentration: 1.0
has only substance units: false

metaM prostge2 e
initial concentration: 1.0
is: CHEBI:606564
initial amount: NaN
has only substance units: false
type: Species
name: prostaglandin E2(1-)
boundary condition: false
is: HMDB01220
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: SBO:0000247

metaR PCHOLP hs
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.4.4
reactant: MODEL1310110004#
is described by: ECO:0000269
product: MODEL1310110004#
reversible: false
type: Reaction
fast: false
name: choline phosphatase
is: SBO:0000176
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_90ae043c_471f_4e54_a900_bc5a0fee024c
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: _J03866_1_m
is encoded by: hsa:J03866
constant: false
boundary condition: true

metaR RE1523M
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000176
modifier: MODEL1310110004#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
name: RE1523
product: MODEL1310110004#
fast: false

metaM oagd3 hs e
has only substance units: false
is: CHEBI:18421
initial concentration: 1.0
name: 9-O-Acetylated GD3
initial amount: NaN
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB02168
type: Species

metaR GLCt4
modifier: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
is described by: ECO:0000269
product: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
reversible: true
name: glucose transport via sodium symport

metaR r0522
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
fast: false
kinetic law: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
reactant: MODEL1310110004#
reversible: false
product: MODEL1310110004#
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
is: SBO:0000176
is described by: ECO:0000000

metaM CE1926 e
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
has only substance units: false
constant: false
name: gama-carboxyethyl-hydroxychroman
boundary condition: false
type: Species
is: CHEBI:15748
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00127

metaM ump g
type: Species
constant: false
is: CHEBI:57865
initial concentration: 1.0
name: UMP(2-)
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
is: SBO:0000247
is: HMDB00288
boundary condition: false
has only substance units: false

metaR INSTt2r
reversible: true
modifier: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
type: Reaction
name: inositol transport in via proton symport
product: MODEL1310110004#
is described by: ECO:0000269

metaR FUMSO4tm
reversible: true
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
name: Fumarate:sulfate antiport, mitochondrial
reactant: MODEL1310110004#
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_4f0565e3_e7d2_4e51_a869_961668d85186
type: Species
is: E9PHN8
initial concentration: NaN
is: SBO:0000252
name: HEPH
initial amount: NaN
is encoded by: hsa:9843
boundary condition: true
has only substance units: false
constant: false

metaM galacglcgalgbside hs c
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
is: HMDB00061
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
is: CHEBI:58343
constant: false
name: Gal-GlcNAc-Gal globoside
initial amount: NaN
boundary condition: false

metaM ksii core4 pre6 g
name: keratan sulfate II biosynthesis, precursor 6
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28067
notes: FORMULA: C69H111N6O51SX CHARGE: -2

metaR DMATTx
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.5.1.1
fast: false
reversible: false
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
is: SBO:0000176
is described by: ECO:0000134
name: dimethylallyltranstransferase
product: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_0bafe5bd_6414_47cb_bbd6_d361f9d1004f
has only substance units: false
type: Species
is encoded by: hsa:23439
has part: Q9UN42
has part: P50993
constant: false
name: ATP1B4:ATP1A2
boundary condition: true
initial amount: NaN
is encoded by: hsa:477
is: SBO:0000297
initial concentration: NaN

metaR FACOAL160i
modifier: MODEL1310110004#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
reversible: false
name: C160 fatty acid activation
product: MODEL1310110004#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM c81crn c
name: octenoyl carnitine
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C15H27NO4 CHARGE: 0
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB13324

metaM lnlncacrn c
is: HMDB06319
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
name: alpha-linolenyl carnitine
has only substance units: false
boundary condition: false

metaR r1447
fast: false
type: Reaction
reversible: false
name: EC:1.3.3.6
is: SBO:0000176
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110004#_5146c201_4e6e_454b_bd4e_c93a0de9e766
boundary condition: true
constant: false
is encoded by: hsa:23600
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
name: AMACR
is: Q9UHK6

metaR r0525
reversible: true
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.9 Confidence Level: 0 AUTHORS: PMID:235294,PMID:4774398 NOTES:
reactant: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110004#
type: Reaction
name: N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase; N6-(L-1,3-Dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-glutamate-forming) Lysine degradation EC:1.5.1.9
fast: false

metaM CE4876 r
name: delta12-Prostaglandin J2
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
is: CHEBI:57923

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

metaM oagd3 hs g
is: C00029
has only substance units: false
is: HMDB00286
initial amount: NaN
is: CHEBI:58367
constant: false
name: 9-O-Acetylated GD3
initial concentration: 1.0
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
type: Species
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_bb10176e_ff86_4a91_a63c_30ead63e2066
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is: P34949
type: Species
constant: false
initial concentration: NaN
name: MPI
is encoded by: hsa:4351

metaM CE4792 m
initial amount: NaN
is: SBO:0000247
name: 3-oxo-cis-8-tetradecenoyl-CoA
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
type: Species
is: CHEBI:57923
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_a332d5ff_acfc_4a2d_814d_7e94d4de739b
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:2882
boundary condition: true
name: GPX7
has only substance units: false
is: Q96SL4
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_d9f68a84_f014_46b1_a100_a04c7125bc7c
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is: Q16718
initial concentration: NaN
name: NDUFA5
is encoded by: hsa:4698
boundary condition: true
constant: false

metaR B3GNT12g
reversible: false
fast: false
modifier: MODEL1310110004#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
product: MODEL1310110004#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
notes: GENE_ASSOCIATION: (10678.1) or (10678.2) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_5d69d3f7_a4c6_4b3d_a8d7_557509b0aa9c
name: NDUFA10
has only substance units: false
constant: false
is encoded by: hsa:4705
initial concentration: NaN
initial amount: NaN
is: O95299
is: SBO:0000252
type: Species
boundary condition: true

metaM tettet6coa c
is: http://identifiers.org/pubchem.compound/47205481
has only substance units: false
is: HMDB06516
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
name: tetracosatetraenoyl coenzyme A
type: Species
is: C16171
constant: false
boundary condition: false
is: SBO:0000247

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR FAOXC160
kinetic law: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110004#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
modifier: MODEL1310110004#
reactant: MODEL1310110004#
name: Beta oxidation of long chain fatty acid

metaR DHCR72r
reactant: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.1.21
name: 7-dehydrocholesterol reductase
fast: false
modifier: MODEL1310110004#

metaR r1448
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110004#
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#
name: EC:1.3.3.6

metaR DPCOAK
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.3
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
name: dephospho-CoA kinase
modifier: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#

metaM galacglcgalgbside hs e
is: CHEBI:0
name: Gal-GlcNAc-Gal globoside
is: HMDB00143
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
boundary condition: false
is: C00124
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false

metaM ahcys e
is: C00021
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C14H20N6O5S CHARGE: 0
is: SBO:0000247
name: S-Adenosyl-L-homocysteine
is: HMDB00939
is: CHEBI:16680
initial amount: NaN

metaR DADA
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.4
reactant: MODEL1310110004#
fast: false
name: Deoxyadenosine deaminase
kinetic law: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
product: MODEL1310110004#
reversible: false

metaR FOLt2le
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000185
product: MODEL1310110004#
reversible: true
name: folate transport via anion exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_ef895092_8d97_45b2_a9d6_8777c80e57b6
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8503
type: Species
constant: false
name: PIK3R3
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q92569

http://identifiers.org/biomodels.db/MODEL1310110004#_e473cdf9_470f_4871_9ab6_570b6aa8e60b
boundary condition: true
is: SBO:0000252
is: E5KNH5
initial amount: NaN
is encoded by: hsa:4723
name: NDUFV1
constant: false
type: Species
has only substance units: false
initial concentration: NaN

metaM hcys L c
is: CHEBI:17588
type: Species
name: L-homocysteine
initial concentration: 1.0
boundary condition: false
is: HMDB00742
has only substance units: false
notes: FORMULA: C4H9NO2S CHARGE: 0 INCHI: InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00151
constant: false
is: SBO:0000247
initial amount: NaN

metaR NACHEX20ly
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110004#
reversible: false
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110004#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR RE2269E
fast: false
modifier: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.21.39
kinetic law: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
reactant: MODEL1310110004#
name: RE2269

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaR r0527
product: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
reactant: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110004#
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42

http://identifiers.org/biomodels.db/MODEL1310110004#_77b26d53_11d5_4b83_bb75_212919d35604
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: COX7A1
is: P24310
is encoded by: hsa:1346
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_29dc09c6_1a3f_4109_a368_a9495c55c1da
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:8897
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: MTMR3

http://identifiers.org/biomodels.db/MODEL1310110004#_0e413fe8_3f1f_4e65_9f16_6d6210b17e97
constant: false
is encoded by: hsa:5152
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: PDE9A
is: SBO:0000252
type: Species

metaR RE1804M
type: Reaction
product: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
reversible: true
name: RE1804
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
fast: false

metaR ITCOALm
reversible: true
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
fast: false
is: SBO:0000176
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.2.1.5
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
reactant: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_c6743c52_d189_4b81_9751_ff90a639eb7c
constant: false
is encoded by: hsa:6487
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: ST3GAL3
initial amount: NaN
type: Species

metaR EX pglyc hs LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylglycerol (homo sapiens) exchange
type: Reaction

metaM btn m
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57586
is: HMDB00030
has only substance units: false
boundary condition: false
name: biotinate
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR GLYCtm
name: glycerol transport
reversible: true
product: MODEL1310110004#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
is described by: ECO:0000000
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_e7971899_226b_4b98_a62e_064553f8bb28
has only substance units: false
is: P22304
is: SBO:0000252
initial concentration: NaN
constant: false
name: IDS
initial amount: NaN
is encoded by: hsa:3423
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_1f2ade42_748c_41a3_8cc6_3b6f8b752480
name: GALK2
type: Species
is encoded by: hsa:2585
is: SBO:0000252
constant: false
is: Q01415
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR GBSIDEte
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - The goal of this transporter is to get globoside to the EC plasma membrane NJ
reversible: true
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185
name: globoside transport
reactant: MODEL1310110004#
is described by: ECO:0000000
type: Reaction

metaR r0671
name: (R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.22
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reversible: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (2717.1) or (6173.1) SUBSYSTEM: CoA synthesis EC Number: 6.3.2.5 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:12906824,PMID:15893380 NOTES:

metaR LEUKTRA4tr
product: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
name: leukotriene intracellular transport
kinetic law: MODEL1310110004#
is described by: ECO:0000000
reactant: MODEL1310110004#
reversible: true
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_9d440865_6c6d_4403_9a5b_a3f3f58de83e
name: ATP5C1
type: Species
is: SBO:0000252
is encoded by: hsa:509
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q6I9V2
constant: false

metaM sphgn c
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: HMDB00269
name: sphinganine(1+)
is: CHEBI:57817

metaR RE2541E
kinetic law: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
reactant: MODEL1310110004#
is: SBO:0000176
type: Reaction
name: RE2541
product: MODEL1310110004#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.31
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_acglc13galacglcgal14acglcgalgluside_hs_g
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: nLc7Cer
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:26174

metaM galacglcgalgbside hs g
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: Gal-GlcNAc-Gal globoside
is: CHEBI:26174
type: Species
boundary condition: false
is: SBO:0000247
constant: false

metaM ump c
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
name: UMP
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: HMDB00288
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57865
is: C00105
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_350e2eb6_cd19_4342_b368_d83c64c66f63
is encoded by: hsa:10558
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: SPTLC1
has only substance units: false
is: O15269
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_ed9c6275_a1d3_4623_b062_b9392cf3dc29
constant: false
has only substance units: false
is: SBO:0000252
is: P80365
is encoded by: hsa:3291
type: Species
initial amount: NaN
name: HSD11B2
initial concentration: NaN
boundary condition: true

metaR FAOXC7C5m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C7-->C5)m
type: Reaction

metaR r0780
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
reversible: true
fast: false
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
product: MODEL1310110004#
is described by: ECO:0000000
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_e128b234_9129_4acf_bc90_908213907e29
is: SBO:0000297
is encoded by: hsa:4830
initial amount: NaN
type: Species
name: NME1:NME2
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaM octd11ecoa m
is: HMDB06294
type: Species
name: 11-octadecenoylcoa
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR FADH2tru
name: FADH2 transporter, endoplasmic reticulum
is described by: ECO:0000000
product: MODEL1310110004#
reversible: false
reactant: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ

metaR PROSTGH2t
product: MODEL1310110004#
reversible: true
type: Reaction
kinetic law: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
name: Prostaglandin H2 transport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is: SBO:0000185

metaR r2094
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110004#
modifier: MODEL1310110004#

metaR HISD
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110004#
reversible: false
reactant: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
product: MODEL1310110004#
fast: false
type: Reaction
name: histidase
is version of: http://identifiers.org/ec-code/4.3.1.3

metaM cl e
is: CHEBI:3966
is: HMDB00492
has only substance units: false
boundary condition: false
name: Chloride
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: Cl CHARGE: -1
type: Species
is: C00115

metaR S6T9g
product: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110004#
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
reversible: false
reactant: MODEL1310110004#
modifier: MODEL1310110004#

metaM 3hexdcrn c
type: Species
initial concentration: 1.0
is: HMDB13336
constant: false
boundary condition: false
name: 3-hydroxyhexadecanoylcarnitine
initial amount: NaN
has only substance units: false
notes: FORMULA: C23H45NO5 CHARGE: 0
is: SBO:0000247

metaM 13 cis retn r
is: HMDB06219
has only substance units: false
is: D00348
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7847414
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
constant: false
name: 13-cis-retinoate

metaR PMEVKx
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
product: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.7.4.2
fast: false
modifier: MODEL1310110004#
name: phosphomevalonate kinase
kinetic law: MODEL1310110004#

metaR r0142
reversible: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110004#
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
is: SBO:0000176
modifier: MODEL1310110004#
fast: false
product: MODEL1310110004#

metaR G14T6g
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_f1eb3260_5dc2_430c_8257_63d384dd200f
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
name: _AI601100_1_m
is encoded by: hsa:AI601100

http://identifiers.org/biomodels.db/MODEL1310110004#_ceae1576_2835_4418_9414_57cd700c0924
is encoded by: hsa:27124
name: INPP5J
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
constant: false

metaR r0781
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#
type: Reaction
reversible: true

metaM ha deg1 l
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: hyaluronan degradation product 1
has only substance units: false
boundary condition: false
is: CHEBI:16336
type: Species
notes: FORMULA: C22H33N2O16 CHARGE: -1

metaR ILETAm
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110004#
name: isoleucine transaminase, mitochondrial
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
fast: false
kinetic law: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
product: MODEL1310110004#
reactant: MODEL1310110004#

metaR SERDGLYexR
is: SBO:0000185
name: D-Serine/Glycine reversible exchange
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000304
reversible: true
type: Reaction
product: MODEL1310110004#

metaR FAOXC181C161x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C18:1-->C16:1)x
type: Reaction

metaR r1435
reactant: MODEL1310110004#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
fast: false
kinetic law: MODEL1310110004#
name: Transport reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110004#

metaM dhap c
is: HMDB01473
is: http://identifiers.org/pubchem.compound/3411
initial amount: NaN
is: C00111
initial concentration: 1.0
has only substance units: false
type: Species
name: Dihydroxyacetone phosphate
is: CHEBI:57642
is: SBO:0000247
boundary condition: false
constant: false

metaR r2093
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110004#
is described by: ECO:0000000
product: MODEL1310110004#

metaR FAOXC161C141x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_ddfa8e65_ec50_42c6_bcbb_f6f9d094dae6
is: Q9UBX3
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:1468
type: Species
name: SLC25A10
initial amount: NaN
has only substance units: false
boundary condition: true

metaM uri e
has only substance units: false
is: HMDB00296
name: Uridine
is: CHEBI:16704
is: C00299
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial amount: NaN
type: Species

metaM 3htdcoa c
boundary condition: false
constant: false
has only substance units: false
name: (S)-3-Hydroxytetradecanoyl-CoA
is: SBO:0000247
type: Species
is: HMDB02014
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0

metaR BTNPL
modifier: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is: SBO:0000176
fast: false
product: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.3.4.10
reversible: false
name: holocarboxylase synthestase (biotin protein ligase)
kinetic law: MODEL1310110004#
type: Reaction

metaM amp x
is: SBO:0000247
name: AMP
boundary condition: false
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: C00020
type: Species
is: HMDB00045
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0

metaM 3tetd7ecoacrn c
type: Species
initial concentration: 1.0
is: HMDB02014
has only substance units: false
initial amount: NaN
notes: FORMULA: C21H39NO5 CHARGE: 0
is: SBO:0000247
constant: false
name: 3-hydroxy tetradecenoyl-7-carnitine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_1fcc9912_8065_4f71_8045_1165d94cafdb
initial concentration: NaN
constant: false
name: ACP1
initial amount: NaN
is encoded by: hsa:52
boundary condition: true
is: SBO:0000252
type: Species
is: P24666
has only substance units: false

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR CBR2
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000176
name: Carbonyl reductase [NADPH] 1
reversible: false
modifier: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.1.1.189
is described by: ECO:0000269
reactant: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ

metaR r2091
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110004#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110004#

metaR H2Otm
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000269
modifier: MODEL1310110004#
fast: false
name: H2O transport, mitochondrial
reversible: true
type: Reaction
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
is: SBO:0000185

metaR SPHMDAc
fast: false
product: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12069827 NOTES:limited details on mechanism, localization, etc. See PMID: 12069827 NJ
is: SBO:0000176
reactant: MODEL1310110004#
name: sphingomyelin deacylase
reversible: false

metaR 3MOX4HOXPGALDOX NADP
is described by: ECO:0000304
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
reversible: true
product: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB

metaR r0483
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
is described by: ECO:0000000
fast: false
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
kinetic law: MODEL1310110004#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110004#
reversible: true
product: MODEL1310110004#

metaR r2092
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110004#
is: SBO:0000185
reactant: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
is described by: ECO:0000000

metaR r1660
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110004#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000

metaR NAt
reversible: true
name: sodium transport (uniport)
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000185
product: MODEL1310110004#
is described by: ECO:0000269
reactant: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (6526.1) or (6523.1) or (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:1372904,PMID:15546855,PMID:2490366,PMID:7537337,PMID:7789985,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:

metaR MG1er
is version of: http://identifiers.org/ec-code/3.2.1.106
product: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
reversible: false
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_a472c917_6a17_40c1_8b29_72fde07bb6af
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
name: ACADVL
is encoded by: hsa:37
is: P49748
type: Species
constant: false
is: SBO:0000252

metaR FAOXC61C4x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)x
type: Reaction

metaR FAS120COA
product: MODEL1310110004#
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110004#
is: SBO:0000176
name: fatty-acyl-CoA synthase (n-C12:0CoA)
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110004#_b0d17239_ab82_4ae6_9668_f9f09a227ef8
type: Species
boundary condition: true
is encoded by: hsa:36
constant: false
name: ACADSB
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: P45954
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_603275b2_882a_42af_8522_8728efcd1623
is: SBO:0000252
name: ACLY
is: P53396
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false
is encoded by: hsa:47
initial amount: NaN

metaR GUACYC
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/4.6.1.2
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000269
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.2 Confidence Level: 4 AUTHORS: PMID:10449911,PMID:10777682,PMID:11565546,PMID:11851379,PMID:1352257,PMID:14748740,PMID:15371450,PMID:7601467,PMID:7761400,PMID:7777544,PMID:7954658,PMID:8838319,PMID:9097965,PMID:9742212 NOTES:IT
is: SBO:0000176
product: MODEL1310110004#
name: guanylate cyclase

metaR r2090
is described by: ECO:0000000
fast: false
modifier: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM 3hibutcoa m
has only substance units: false
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:28259
name: (S)-3-Hydroxyisobutyryl-CoA
constant: false
is: HMDB01052

metaR RE2660C
reactant: MODEL1310110004#
reversible: true
name: RE2660
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:

metaR H2Otn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
name: H2O transport, nuclear
reactant: MODEL1310110004#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110004#
reversible: true
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_5c77f1c0_43d6_46bc_9851_143a0b7fad72
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: P27338
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: MAOB
is encoded by: hsa:4129

http://identifiers.org/biomodels.db/MODEL1310110004#_91d89a11_1347_42f5_adf1_6994d5e6809b
boundary condition: true
is encoded by: hsa:23236
constant: false
name: PLCB1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species

metaR LEUTAm
product: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
reversible: true
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
name: leucine transaminase, mitochondrial
modifier: MODEL1310110004#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is described by: ECO:0000269

metaM acgam6p c
initial amount: NaN
name: N-acetyl-D-glucosamine 6-phosphate(2-)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: CHEBI:57513
is: HMDB01062

metaR r0698
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.2.27
modifier: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true

metaM dhap e
has only substance units: false
name: glycerone phosphate(2-)
constant: false
boundary condition: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
is: HMDB01473
initial concentration: 1.0
is: CHEBI:57642
type: Species
is: SBO:0000247
initial amount: NaN

metaM uri c
constant: false
is: CHEBI:16704
is: SBO:0000247
has only substance units: false
type: Species
is: C00299
name: Uridine
initial concentration: 1.0
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
boundary condition: false
initial amount: NaN
is: HMDB00296

metaM 5fthf m
is: HMDB01562
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
name: 5-formyltetrahydrofolate(2-)
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57457

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaM 3tetd7ecoacrn e
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB02014
initial amount: NaN
type: Species
name: 3-hydroxy tetradecenoyl-7-carnitine
boundary condition: false
notes: FORMULA: C21H39NO5 CHARGE: 0

metaR DAGKn hs
type: Reaction
product: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
name: Diacylglycerol phosphate kinase (homo sapiens)
reactant: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.1.107
is: SBO:0000176
modifier: MODEL1310110004#
is described by: ECO:0000269

metaM tetdecdicoa x
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
name: 5,8-tetradecadienoylcoa
is: HMDB02288

metaR ALCD2yf
modifier: MODEL1310110004#
reactant: MODEL1310110004#
reversible: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
product: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
name: alcohol dehydrogenase (ethanol, NADP), forward reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_cbfd9772_e368_4c8b_bc54_4156da0f2002
has only substance units: false
is encoded by: hsa:51102
name: MECR
is: SBO:0000252
is: Q9BV79
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
boundary condition: true

metaR O2t
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110004#
name: o2 transport (diffusion)
kinetic law: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD

metaR r0784
type: Reaction
modifier: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
fast: false
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.1.38
is described by: ECO:0000000
reversible: true
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
product: MODEL1310110004#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110004#_08b07926_59db_49de_899d_77760b51f536
type: Species
boundary condition: true
constant: false
initial concentration: NaN
name: CHAT
is: Q6LEN6
has only substance units: false
initial amount: NaN
is encoded by: hsa:1103
is: SBO:0000252

metaR G14T10g
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
reactant: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
reversible: false
modifier: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.38

metaR H2Otg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: H2O transport, Golgi apparatus
reversible: true
fast: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

metaM dcyt e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00014
is: C00881
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
type: Species
is: SBO:0000247
has only substance units: false
name: Deoxycytidine
is: CHEBI:15698

metaR GTHRDtr
name: glutathione transport via diffusion
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - NJ
reactant: MODEL1310110004#

metaM xoldioloneh c
is: SBO:0000247
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
boundary condition: false
is: HMDB06887
is: CHEBI:2288
initial amount: NaN

metaR CITRtm
fast: false
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: citrulline mitochondrial transport via proton antiport
is described by: ECO:0000269
modifier: MODEL1310110004#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true
product: MODEL1310110004#

metaR FAOXC2251836m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
reversible: false
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
reactant: MODEL1310110004#
is described by: ECO:0000000
name: Beta oxidation of fatty acid
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM 3octpencoa m
is: SBO:0000247
name: 3,6,9,12,15-octadecapentenoylcoa
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/5280355
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_704d3a19_cf7f_4fd7_bac7_fc1183a1afb6
type: Species
is encoded by: hsa:3420
has only substance units: false
name: IDH3A:IDH3B:IDH3G
is: SBO:0000297
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

metaR HDECEACBP
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecenoylcoa from mitochondria into the cytosol
type: Reaction

metaM pail34p hs c
is: CHEBI:57658
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
has only substance units: false
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)

metaM 4abut m
is: C00334
is: HMDB00112
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:16865
name: 4-Aminobutanoate
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_2d6ab008_9528_4ece_84e3_4be2e8ed6a34
is: Q6P4B4
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PFAS
is encoded by: hsa:5198

http://identifiers.org/biomodels.db/MODEL1310110004#_046a7463_99bc_49c7_a7a2_873b01745788
has only substance units: false
initial amount: NaN
is: O15427
name: SLC16A3
boundary condition: true
constant: false
is encoded by: hsa:9123
is: SBO:0000252
type: Species
initial concentration: NaN

metaR CERT2rt
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000185
fast: false
name: ceramide transport protein
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110004#
reversible: true

metaM 10fthf5glu e
type: Species
is: CHEBI:57454
boundary condition: false
has only substance units: false
constant: false
name: 10-formyltetrahydrofolate-[Glu](5)
notes: FORMULA: C40H45N11O19 CHARGE: -6
initial concentration: 1.0
is: HMDB00972
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_c9cd8687_6707_4ede_906d_5a48942e8222
is: P21399
initial concentration: NaN
is encoded by: hsa:48
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ACO1
type: Species
boundary condition: true
constant: false

metaR ADNCYC
reversible: false
reactant: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
type: Reaction
name: adenylate cyclase
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
modifier: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.6.1.1
is described by: ECO:0000269

metaR r0782
reversible: false
is: SBO:0000176
name: GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#

metaM 3hexdcrn e
boundary condition: false
name: 3-hydroxyhexadecanoylcarnitine
type: Species
is: HMDB13336
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C23H45NO5 CHARGE: 0

metaM cl c
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:3966
name: Chloride
initial concentration: 1.0
is: SBO:0000247
is: HMDB00492
constant: false
initial amount: NaN
notes: FORMULA: Cl CHARGE: -1
is: C00115

metaM dcyt c
has only substance units: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
is: HMDB00014
name: Deoxycytidine
initial concentration: 1.0
is: C00881
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:15698
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_9508cb66_1153_4175_9e5f_44e2e07ef9b8
name: COX6B1
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P14854
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1340
constant: false

metaR BPNT
modifier: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.3.7
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
type: Reaction
reversible: false
is described by: ECO:0000269
product: MODEL1310110004#
is: SBO:0000176
fast: false
name: 3',5'-bisphosphate nucleotidase
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_27c3bf9d_a942_4157_a434_dc115144fc88
type: Species
has only substance units: false
name: ST3GAL1
initial amount: NaN
constant: false
is encoded by: hsa:6482
is: Q11201
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR Q10H2e
type: Reaction
fast: false
name: transport of ubiquinol into lymph
is described by: ECO:0000134
product: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_99130031_d2a1_4471_9082_7617eb9c6263
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
name: DGKH
type: Species
constant: false
is encoded by: hsa:160851
is: SBO:0000252
is: A8K0I1

metaM CE2705 n
name: quinonoid dihydrobiopterin
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: CHEBI:15374
is: SBO:0000247
is: HMDB02281
boundary condition: false

metaR DCK2n
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110004#
name: Deoxycytidine kinase, nuclear (UTP)
reversible: true
is: SBO:0000176
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
product: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
is version of: http://identifiers.org/ec-code/2.7.1.74

http://identifiers.org/biomodels.db/MODEL1310110004#_73b79916_4875_4fb7_8676_a26d0347bd74
has only substance units: false
name: SLC35C1
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:55343
boundary condition: true
is: B3KQH0
is: SBO:0000252

metaM C05279 m
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB11123
type: Species
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
has only substance units: false
boundary condition: false
name: trans,cis-Lauro-2,6-dienoyl-CoA
is: CHEBI:28387
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_f2f15a10_1b22_4f57_8b86_e2f80038c606
type: Species
is: Q6P1K9
is encoded by: hsa:80025
name: PANK2
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR r0783
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
type: Reaction
reversible: true

metaR r0145
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
is described by: ECO:0000000
modifier: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.8.3.1
type: Reaction
is: SBO:0000176
reversible: true
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
fast: false

metaR UMPK3n
fast: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110004#
is: SBO:0000176
name: UMP kinase (UTP),nuclear
modifier: MODEL1310110004#
product: MODEL1310110004#
type: Reaction

metaR r0480
fast: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
is: SBO:0000176
reactant: MODEL1310110004#
reversible: true
product: MODEL1310110004#
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000

metaR RE3000M
modifier: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: RE3000
type: Reaction
product: MODEL1310110004#
kinetic law: MODEL1310110004#

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR MALTSULtm
fast: false
reversible: true
modifier: MODEL1310110004#
is: SBO:0000185
type: Reaction
name: Malate:thiosulfate antiport, mitochondrial
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269

metaR r1433
reactant: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110004#
fast: false
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
reversible: false
is: SBO:0000176

metaM dgdp c
has only substance units: false
is: SBO:0000247
name: dGDP
is: CHEBI:58595
initial concentration: 1.0
constant: false
is: HMDB00960
is: C00361
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_e188db6b_136d_4202_8084_9a57db0c1730
initial amount: NaN
name: B3GALT5
boundary condition: true
is: SBO:0000252
is: Q9Y2C3
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:10317
type: Species

metaR r0788
fast: false
reversible: true
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
kinetic law: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.14.13.15
is: SBO:0000176
modifier: MODEL1310110004#

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_f552fb28_141e_4bc8_9fcc_cf54edd5ea55
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: PGM2
has only substance units: false
is encoded by: hsa:55276
type: Species
is: Q96G03

metaM retinol e
type: Species
is: CHEBI:50211
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00305
name: retinol
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_1e639d1a_d6a1_4f45_aae0_272fbd228c59
boundary condition: true
is: Q9Y673
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:29880
has only substance units: false
initial concentration: NaN
name: ALG5
initial amount: NaN

metaM lgnccoa x
initial concentration: 1.0
is: HMDB06526
type: Species
boundary condition: false
name: lignocericyl coenzyme A
has only substance units: false
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
constant: false
initial amount: NaN
is: SBO:0000247

metaR H2Ot
modifier: MODEL1310110004#
is described by: ECO:0000269
name: H2O transport via diffusion
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD
reactant: MODEL1310110004#
is: SBO:0000185
type: Reaction
product: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
fast: false

metaR ABO7g
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.37
fast: false
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
reversible: false
type: Reaction
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
reactant: MODEL1310110004#

metaM HC01403 m
constant: false
name: (S)-Hydroxydecanoyl-CoA
is: CHEBI:28325
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
is: SBO:0000247
type: Species

metaM 34dhoxmand m
initial concentration: 1.0
name: 3,4-Dihydroxymandelate
is: CHEBI:27637
is: HMDB01866
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaR GLUDym
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
name: glutamate dehydrogenase (NADP), mitochondrial
type: Reaction
product: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.4.1.3
fast: false
modifier: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110004#_3a5685a0_fd2b_4de3_954d_08a2cd2db1c8
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: P48775
is encoded by: hsa:6999
name: TDO2

metaR NaKt
reversible: false
reactant: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: (481.1 and 478.1) or (477.1 and 23439.1) or (483.1 and 476.1) or (481.1 and 480.1) or (482.1 and 478.1) or (482.1 and 476.1) or (482.1 and 477.1) or (481.1 and 476.1) or (23439.1 and 476.1) or (480.1 and 23439.1) or (481.1 and 477.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.9 Confidence Level: 4 AUTHORS: PMID:10456317,PMID:8833915,PMID:9159180 NOTES:AMF TDV (8/25/2005, stoichiometry changed)
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/3.6.3.9
modifier: MODEL1310110004#
is described by: ECO:0000269
name: Na+/K+ exchanging ATPase

metaR r0587
type: Reaction
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
kinetic law: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
reactant: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
is described by: ECO:0000000

metaR r0789
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
product: MODEL1310110004#
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.14.13.15
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: true

metaM ivcoa m
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
boundary condition: false
name: Isovaleryl-CoA
is: HMDB01113
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:57345

http://identifiers.org/biomodels.db/MODEL1310110004#_69cfd24d_ee9a_4769_879c_88b74ca1fee7
has only substance units: false
initial concentration: NaN
type: Species
is: Q8TE54
name: SLC26A7
boundary condition: true
is encoded by: hsa:115111
is: SBO:0000252
constant: false
initial amount: NaN

metaM dmnoncoa x
is: SBO:0000247
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
boundary condition: false
has only substance units: false
is: HMDB11604
constant: false
name: 4,8 dimethylnonanoyl-CoA
type: Species
initial amount: NaN
initial concentration: 1.0

metaM arachcrn m
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
name: arachidyl carnitine
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB06460
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_391c969c_07e4_47b6_9531_18996f85b905
is: Q16795
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: NDUFA9
is encoded by: hsa:4704
initial concentration: NaN
is: SBO:0000252
constant: false

metaM ksii core4 pre7 g
is: CHEBI:58053
notes: FORMULA: C75H121N6O56SX CHARGE: -2
initial concentration: 1.0
has only substance units: false
type: Species
name: keratan sulfate II biosynthesis, precursor 7
is: HMDB00175
constant: false
boundary condition: false
initial amount: NaN
is: C00130
is: SBO:0000247

metaR TCHOLAte
product: MODEL1310110004#
is: SBO:0000185
name: bile acid intracellular transport
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
kinetic law: MODEL1310110004#
is described by: ECO:0000000

metaR r1116
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
fast: false

metaM amp m
name: AMP(2-)
type: Species
is: HMDB00045
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:456215

metaR r0584
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_2c5c7aa2_0c0a_48a5_9af8_e9a45cc4d22f
constant: false
name: DPM2
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: O94777
type: Species
initial amount: NaN
is encoded by: hsa:8818
boundary condition: true

metaM zymst r
is: HMDB06271
boundary condition: false
constant: false
name: zymosterol
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
is: CHEBI:18252
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_3ae002e1_d833_4cfd_919b_c670ed28e837
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: SLC26A1
is encoded by: hsa:10861

http://identifiers.org/biomodels.db/MODEL1310110004#_6db4b0f3_599c_468c_9a22_5c05d2f4337d
is encoded by: hsa:5232
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
name: PGK2
is: SBO:0000252
is: P07205

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_3a1e5295_a6f8_4e4f_97c7_7a9eb42ed0b7
type: Species
is: P15309
is encoded by: hsa:55
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: ACPP

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR S6TASE16ly
product: MODEL1310110004#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110004#_01d1334d_71f0_43f1_87ee_5d055f06e490
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
name: ACAD8
has only substance units: false
is encoded by: hsa:27034
is: Q6ZWP6

metaR C226CPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
kinetic law: MODEL1310110004#
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110004#
name: C226 transport into the mitochondria
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
modifier: MODEL1310110004#

metaR BILDGLCURt
modifier: MODEL1310110004#
type: Reaction
is described by: ECO:0000269
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
fast: false
product: MODEL1310110004#
is: SBO:0000185
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: true

metaR r2099
reversible: true
modifier: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110004#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_19c84177_11ec_4fb0_ade7_2791f71be624
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:515
name: ATP5F1
has only substance units: false
is: SBO:0000252
boundary condition: true

metaM sebacid c
name: sebacicacid
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: C08277
is: HMDB00792
type: Species
notes: FORMULA: C10H16O4 CHARGE: -2
initial amount: NaN

metaR r1117
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
name: Facilitated diffusion
product: MODEL1310110004#
is: SBO:0000185
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:

metaR D3AIBTm
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
kinetic law: MODEL1310110004#
type: Reaction
reversible: true
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
fast: false
is: SBO:0000176
product: MODEL1310110004#

metaR ACCOAtn
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reversible: true
reactant: MODEL1310110004#
name: acetyl-CoA transport, nuclear
is: SBO:0000185

metaR G14T21g
kinetic law: MODEL1310110004#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110004#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110004#
is described by: ECO:0000000
type: Reaction

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaM retfa c
initial concentration: 1.0
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial amount: NaN
type: Species
is: HMDB00305
is: CHEBI:50211
has only substance units: false
boundary condition: false
name: fatty acid retinol
constant: false
is: SBO:0000247

metaR r0787
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
product: MODEL1310110004#
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110004#
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.1

http://identifiers.org/biomodels.db/MODEL1310110004#_22ac9949_1267_4450_9155_2af7b54a14ef
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:28232
constant: false
initial amount: NaN
initial concentration: NaN
is: Q9UIG8
is: SBO:0000252
name: SLCO3A1

metaR C226CPT1
kinetic law: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
name: carnitine C22:6 transferase
is described by: ECO:0000000
modifier: MODEL1310110004#
fast: false
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR 25HVITD3t
is described by: ECO:0000000
kinetic law: MODEL1310110004#
is: SBO:0000185
reactant: MODEL1310110004#
fast: false
reversible: false
name: 25-hydroxyvitamin D3 transport from cytoplasm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12045394 NOTES:is found in blood --> subsequently has to be transported but how? based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT. Biochemical
product: MODEL1310110004#

metaR ORNt3m
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
reversible: true
type: Reaction
modifier: MODEL1310110004#
is described by: ECO:0000269
name: ornithine mitochondrial transport via proton antiport
fast: false

metaR r2098
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
is described by: ECO:0000000
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_41893b47_f628_433f_8f37_3a09d67ee4f1
name: HMGCS1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3157
initial amount: NaN
boundary condition: true
type: Species
is: Q01581
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_126a7975_2d35_4046_bd7c_fde10c61b70c
name: ABCB4
is encoded by: hsa:5244
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_6d1ca063_6475_4ebd_a100_832a2ebeefe9
name: PKLR
is encoded by: hsa:5313
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: P30613
is: SBO:0000252
type: Species
boundary condition: true

metaM srtn e
boundary condition: false
is: SBO:0000247
is: CHEBI:350546
is: HMDB00259
name: serotonin(1+)
type: Species
has only substance units: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial amount: NaN
constant: false
initial concentration: 1.0

metaM gpi prot hs r
is: SBO:0000247
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0
is: CHEBI:7896
name: {[(Prot-PE-Man),(PE)-Man],[PE]}-Man-GlcN-acylPI
initial amount: NaN
is: C00249
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
has only substance units: false
is: HMDB00220

metaR PI34P5K
product: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.1.68
kinetic law: MODEL1310110004#
reversible: false

metaR ARGtiDF
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000269
type: Reaction
name: L-arginine transport via diffusion (extracellular to cytosol)
reversible: false
fast: false
reactant: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
product: MODEL1310110004#

metaR ACETONEt2
fast: false
is: SBO:0000185
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
product: MODEL1310110004#
type: Reaction
name: acetone transport via proton symport

metaM ac e
type: Species
is: HMDB00042
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
is: SBO:0000247
boundary condition: false
name: acetate
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:30089

metaM fald c
initial concentration: 1.0
has only substance units: false
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
boundary condition: false
is: HMDB01426
initial amount: NaN
constant: false
is: SBO:0000247
name: formaldehyde
is: CHEBI:16842
type: Species

metaR r0377
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: false
reactant: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
fast: false
type: Reaction
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
is: SBO:0000176
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:

metaM ca2 e
initial concentration: 1.0
constant: false
type: Species
is: HMDB00464
boundary condition: false
has only substance units: false
name: calcium(2+)
is: SBO:0000247
is: CHEBI:29108
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial amount: NaN

metaR r2097
reactant: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110004#
reversible: true

metaR FUT99g
is: SBO:0000176
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.152
is described by: ECO:0000269
kinetic law: MODEL1310110004#
fast: false
reversible: false
modifier: MODEL1310110004#
name: Alpha-(1,3)-fucosyltransferase
type: Reaction
reactant: MODEL1310110004#

metaR ATPtx
type: Reaction
reversible: true
product: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
name: ATP transporter, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
fast: false

metaR EX 34hpp
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaM hs deg16 l
constant: false
initial amount: NaN
is: HMDB02704
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
initial concentration: 1.0
is: CHEBI:21338
is: SBO:0000247
name: heparan sulfate, degradation product 16
boundary condition: false
has only substance units: false
type: Species

metaM 4abut e
is: SBO:0000247
notes: FORMULA: C4H9NO2 CHARGE: 0
is: HMDB00112
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C00334
is: CHEBI:3628
type: Species
boundary condition: false
name: 4-Aminobutanoate

metaR PPCOAOm
kinetic law: MODEL1310110004#
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110004#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
reversible: false
modifier: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
is described by: ECO:0000269

metaM retfa e
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
boundary condition: false
is: CHEBI:15963
name: fatty acid retinol
type: Species
is: HMDB00508

http://identifiers.org/biomodels.db/MODEL1310110004#_3392ec1a_2dab_464e_b760_5c4833457221
is: Q6IBE6
type: Species
constant: false
name: ST3GAL4
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6484
boundary condition: true
initial amount: NaN

metaR r1728
product: MODEL1310110004#
name: Y+LAT2 Utilized transport
type: Reaction
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
fast: false
modifier: MODEL1310110004#

metaR H2Otp
is described by: ECO:0000000
name: H2O transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_e59582b2_2c7a_4b35_9432_11109dca6449
is: P43034
initial amount: NaN
constant: false
name: PAFAH1B1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5048
type: Species
is: SBO:0000252
boundary condition: true

metaR ACGALtlg
type: Reaction
reversible: true
product: MODEL1310110004#
reactant: MODEL1310110004#
name: N-acetyl-galactosamine intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism - may be vesicular NJ

metaR r0027
reactant: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
is: SBO:0000176
reversible: true
modifier: MODEL1310110004#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.39
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
kinetic law: MODEL1310110004#
fast: false

metaR FAOXC61C4m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaR r2096
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000185
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
is described by: ECO:0000000

metaR FUCASEe
is: SBO:0000176
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110004#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.51
reactant: MODEL1310110004#
name: alpha-fucosidase, extracellular
reversible: false
modifier: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_452f269e_36c8_429e_85d3_0d22625ca2cf
name: ALDH2
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:217
boundary condition: true
is: P05091

metaM eipencoa x
name: 2,5,8,11,14-eicosapentaenoylcoa
initial amount: NaN
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_7852806f_bd01_4a38_ab40_401cd14ff1fc
boundary condition: true
constant: false
is encoded by: hsa:2629
initial concentration: NaN
initial amount: NaN
is: B7Z6S9
is: SBO:0000252
name: GBA
type: Species
has only substance units: false

metaR FAOXC161C141m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

metaM ksii core2 pre4 g
initial concentration: 1.0
is: CHEBI:58053
type: Species
notes: FORMULA: C53H86N4O38X CHARGE: -1
is: C00130
is: SBO:0000247
constant: false
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 4
initial amount: NaN
has only substance units: false
is: HMDB00175

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaM amp r
name: AMP
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: SBO:0000247
is: C00020
constant: false
initial concentration: 1.0
is: HMDB00045
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:456215

metaM ac c
initial amount: NaN
is: CHEBI:30089
is: SBO:0000247
is: HMDB00042
name: acetate
type: Species
constant: false
has only substance units: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
initial concentration: 1.0

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_f5eb6fab_a85b_4bce_a6bb_6766a8e3464e
type: Species
is: SBO:0000252
name: PIP5K1C
initial amount: NaN
constant: false
boundary condition: true
is: O60331
has only substance units: false
is encoded by: hsa:23396
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_dbd0ec0a_cae0_4a3b_9ea0_5855c3c32579
is encoded by: hsa:5152
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
name: PDE9A
has only substance units: false
initial amount: NaN

metaR GLCNACASE1ly
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
product: MODEL1310110004#
modifier: MODEL1310110004#
name: alpha-N-acetylglucosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.50
reversible: false
kinetic law: MODEL1310110004#
fast: false
type: Reaction
is: SBO:0000176

metaM CE2431 m
name: cis-deca-4-enoyl-CoA
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:57795
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
type: Species

metaR 34DHPLACOX
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
is: SBO:0000176
modifier: MODEL1310110004#
reactant: MODEL1310110004#
reversible: false
kinetic law: MODEL1310110004#
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB

metaM crm hs c
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false
boundary condition: false
name: N-acylsphingosine
is: CHEBI:52639

metaM ca2 c
is: SBO:0000247
is: HMDB00464
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: CHEBI:29108
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
name: calcium(2+)
constant: false
initial concentration: 1.0

metaR r2095
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110004#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185
modifier: MODEL1310110004#

metaM 4abut c
initial concentration: 1.0
name: 4-Aminobutanoate
boundary condition: false
is: HMDB00112
notes: FORMULA: C4H9NO2 CHARGE: 0
type: Species
is: CHEBI:3628
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C00334
constant: false

metaR THMP
type: Reaction
product: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
name: thiamin phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
is described by: ECO:0000000
is: SBO:0000176
reversible: false
fast: false

metaM CE5119 m
is: SBO:0000247
boundary condition: false
has only substance units: false
name: trans-3-cis-8-tetradecadienoyl-CoA
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57923
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119

metaM 3mb2coa m
name: 3-methylbut-2-enoyl-CoA(4-)
constant: false
is: HMDB01493
initial amount: NaN
is: CHEBI:57344
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM tetdecdicoa m
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
name: 5,8-tetradecadienoylcoa
boundary condition: false
constant: false
is: HMDB02288
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

metaR FUT16g
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.69
fast: false
is: SBO:0000176
reversible: false
name: Galactoside 2-alpha-L-fucosyltransferase 1
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
product: MODEL1310110004#
type: Reaction

metaR C81CPT1
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of ocetenoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_1c845f4c_5131_433b_a255_e6b20115106d
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AI656480
name: _AI656480_1_m
has only substance units: false
constant: false
initial amount: NaN

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_2f876b59_4696_4e01_8bf6_a2940b35c50c
constant: false
name: CDIPT
is: A8K3L7
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:10423
has only substance units: false

metaR EX tmndnc LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: timnodonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_5149010a_a1f1_4ea9_8a8c_a2364fea175e
is encoded by: hsa:AI934540
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: _AI934540_1_c
type: Species
boundary condition: true
initial amount: NaN

metaR ADRNCOAtx
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
type: Reaction
reactant: MODEL1310110004#
is described by: ECO:0000000
name: fatty acid intracellular transport
is: SBO:0000185
product: MODEL1310110004#
kinetic law: MODEL1310110004#

metaR r0591
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is described by: ECO:0000000
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
modifier: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
kinetic law: MODEL1310110004#
fast: false

metaM dnad c
has only substance units: false
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
constant: false
initial concentration: 1.0
is: C00857
type: Species
is: HMDB01179
boundary condition: false
is: SBO:0000247
name: Deamino-NAD+
is: CHEBI:18304
initial amount: NaN

metaR HSPGtly
reversible: false
product: MODEL1310110004#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
name: heparan sulfate transport, extracellular to lysosome
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_c008633a_c63b_436b_837f_c8655957cc93
is encoded by: hsa:6818
constant: false
name: SULT1A3
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252

metaR GLCNACPT U
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reversible: false
type: Reaction
reactant: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.8.15
modifier: MODEL1310110004#
fast: false
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD

metaM fmn c
is: CHEBI:58210
constant: false
is: SBO:0000247
type: Species
name: FMN
has only substance units: false
initial amount: NaN
is: HMDB01520
boundary condition: false
is: C00061
initial concentration: 1.0
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061

metaR r0590
kinetic law: MODEL1310110004#
reversible: false
modifier: MODEL1310110004#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
reactant: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110004#_1d3b82c7_1c4f_4542_8d35_f0466fd9cff6
is encoded by: hsa:54675
boundary condition: true
type: Species
name: CRLS1
is: Q9UJA2
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_5b96e8c8_8171_45e3_b55d_9cfc4c9c6f54
type: Species
name: ALG6
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:29929
boundary condition: true
is: Q9Y672
constant: false
initial concentration: NaN

metaM amp e
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
is: C00020
constant: false
is: HMDB00045
initial amount: NaN
name: AMP
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:456215

metaR SACCD3m
is described by: ECO:0000269
name: saccharopine dehydrogenase (NADP, L-lysine forming), mitochondrial
type: Reaction
fast: false
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.5.1.8
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.8 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
product: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000176
reversible: false
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_8132a879_4f3b_4b0d_a9d4_44b54c3f1075
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5167
name: ENPP1
boundary condition: true
has only substance units: false
constant: false
is: P22413

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR FAOXC101C102x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_a22f6639_b191_481d_9064_c597c70bc0e1
boundary condition: true
name: DGKZ
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8525
is: SBO:0000252
is: B7Z6M3
constant: false
initial amount: NaN
type: Species

metaM c16dc e
notes: FORMULA: C23H42NO6 CHARGE: -1
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB00712
initial concentration: 1.0
name: Hexadecanedioic acid mono-L-carnitine ester
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_2ada65bc_dfe0_47a7_8bfa_410956febc25
type: Species
is: P20933
constant: false
initial amount: NaN
name: AGA
is encoded by: hsa:175
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR P4507A1r
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
modifier: MODEL1310110004#
name: cytochrome P450, family 7, subfamily A, polypeptide 1
product: MODEL1310110004#
reversible: false
fast: false
kinetic law: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.13.17
reactant: MODEL1310110004#

metaM srtn c
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
is: HMDB00259
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:350546
name: serotonin(1+)

metaR NDP8ex
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
reversible: false
is version of: http://identifiers.org/ec-code/3.6.1.6
is described by: ECO:0000269
name: nucleoside-diphosphatase (UTP), extracellular
fast: false
reactant: MODEL1310110004#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110004#_d9b28967_7ec7_4e5b_9ec7_e083fce0d066
initial amount: NaN
constant: false
is: O75106
is encoded by: hsa:314
name: AOC2
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_a61d4694_268d_4e92_ad7f_fd5d65110847
boundary condition: true
has only substance units: false
is: Q16222
is encoded by: hsa:6675
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: UAP1

http://identifiers.org/biomodels.db/MODEL1310110004#_1a7ba66f_93a3_4d14_9c6e_e988ed45d795
is encoded by: hsa:515
boundary condition: true
is: SBO:0000297
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_0171121a_07fc_439b_ace4_f93c1dd637d4
has only substance units: false
name: PIGF:PIGG
initial concentration: NaN
is: SBO:0000297
has part: Q8NCI4
type: Species
initial amount: NaN
is encoded by: hsa:54872
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_07096459_a000_4713_808b_59afff329829
is encoded by: hsa:8611
is: SBO:0000252
initial amount: NaN
constant: false
is: G3XA95
has only substance units: false
name: PPAP2A
type: Species
initial concentration: NaN
boundary condition: true

metaR FACOAL224
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
modifier: MODEL1310110004#
fast: false
reversible: true
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
is described by: ECO:0000000

metaR MAL Lte
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
is: SBO:0000185
reversible: true
name: Transport of L-malate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
product: MODEL1310110004#
is described by: ECO:0000134

metaM 2mop c
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
name: 2-methyl-3-oxopropanoate
boundary condition: false
initial amount: NaN
is: HMDB01172
has only substance units: false
is: CHEBI:57700

metaM ksi deg30 l
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
name: keratan sulfate I, degradation product 30
is: HMDB00143
is: CHEBI:12936

metaM dag hs c
is: SBO:0000247
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:18035
initial concentration: 1.0
name: diglyceride
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_3128ca33_ba90_45d8_8f51_b1a3ec8652c7
is encoded by: hsa:2629
has only substance units: false
name: GBA
is: SBO:0000252
initial amount: NaN
is: B7Z6S1
type: Species
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_be13eb83_2969_41f3_944f_fdeb831e0e98
is encoded by: hsa:146712
name: B3GNTL1
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: Q67FW5
type: Species

metaR r1657
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reactant: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110004#

metaR C12DCACOT
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

metaM 3hdececrn c
is: HMDB02014
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C23H43NO5 CHARGE: 0
type: Species
name: 3-hydroxyhexadecenoylcarnitine
has only substance units: false
initial concentration: 1.0

metaR SPC HSt
name: sphingosylphosphorylcholine transport (diffusion)
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110004#
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110004#_27647f6b_8c98_4972_9026_41a4e215efde
has part: P48728
is encoded by: hsa:2653
is encoded by: hsa:275
initial amount: NaN
has part: P23434
name: DLD:GCSH:GLDC:AMT
is encoded by: hsa:2731
is: SBO:0000297
constant: false
has part: P23378
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

metaR RE0453C
product: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
name: RE0453
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000176
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:

metaR r2352
type: Reaction
product: MODEL1310110004#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110004#
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_8e08889c_2934_4b64_8b1b_570b2f4d8605
type: Species
is: Q99714
initial amount: NaN
name: HSD17B10
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:3028
boundary condition: true
initial concentration: NaN

metaR GGH 7DHFe
is described by: ECO:0000000
product: MODEL1310110004#
kinetic law: MODEL1310110004#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
fast: false
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
type: Reaction
reversible: false
reactant: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110004#

metaM core6 l
initial concentration: 1.0
boundary condition: false
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: CHEBI:12936
name: Core 6
is: HMDB00143
is: SBO:0000247
has only substance units: false

metaR GGH 10FTHF6GLUe
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
kinetic law: MODEL1310110004#
is: SBO:0000176
fast: false
reactant: MODEL1310110004#
modifier: MODEL1310110004#
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
reversible: false
product: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

metaR 4HGLSDm
name: L-4-hydroxyglutamate semialdehyde dehydrogenase, mitochondrial
modifier: MODEL1310110004#
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.5.1.12
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
reactant: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#

metaM ksi pre16 g
is: C00130
is: HMDB00175
constant: false
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 16
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:58053

metaR TETPENT3t
name: fatty acid transport via diffusion
is: SBO:0000185
kinetic law: MODEL1310110004#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_57629e75_eec5_48e5_bd50_040339b24ec8
initial amount: NaN
is: SBO:0000252
name: _AI285872_1_c
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:AI285872
has only substance units: false

metaR HEXDCRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecanoyl carnitine into extra cellular space
type: Reaction

metaM dhap x
is: HMDB01473
initial concentration: 1.0
constant: false
is: C00111
is: http://identifiers.org/pubchem.compound/3411
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:57642
name: Dihydroxyacetone phosphate
is: SBO:0000247

metaR r1658
kinetic law: MODEL1310110004#
is: SBO:0000185
product: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM c16dc c
notes: FORMULA: C23H42NO6 CHARGE: -1
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: Hexadecanedioic acid mono-L-carnitine ester
is: HMDB00712
has only substance units: false

metaM HC00319 m
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: Malonate
is: CHEBI:30794

http://identifiers.org/biomodels.db/MODEL1310110004#_4df7f415_41ce_4325_9dd3_a7180bea5c50
is: SBO:0000252
constant: false
name: HYAL3
initial concentration: NaN
is encoded by: hsa:8372
initial amount: NaN
boundary condition: true
is: O43820
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_55ac2bcc_580f_4f28_9bac_f20588da5b71
is: Q16762
is: SBO:0000252
name: TST
type: Species
has only substance units: false
is encoded by: hsa:7263
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaR FACOAL226
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
fast: false
reversible: true
type: Reaction
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110004#
is: SBO:0000176
name: fatty-acid--CoA ligase
product: MODEL1310110004#
is described by: ECO:0000000

metaR r0033
modifier: MODEL1310110004#
product: MODEL1310110004#
reversible: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
is described by: ECO:0000000
reactant: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.6.1.5

metaR DAGt
name: diacylglycerol transport
reactant: MODEL1310110004#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110004#
fast: false
product: MODEL1310110004#
is: SBO:0000185

metaM 44mctr r
initial amount: NaN
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
constant: false
initial concentration: 1.0
is: HMDB01023
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
has only substance units: false
type: Species
is: CHEBI:17813
boundary condition: false
is: SBO:0000247

metaR r2353
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110004#
fast: false
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110004#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_c87e6a93_a86a_4c82_853f_3fcdef2845dc
is: O75489
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:4722
has only substance units: false
name: NDUFS3
boundary condition: true
is: SBO:0000252

metaR GALASE18ly
reactant: MODEL1310110004#
fast: false
name: beta-galactosidase, lysosomal
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110004#
is described by: ECO:0000000

metaM ksi deg41 l
boundary condition: false
notes: FORMULA: C34H58N2O26 CHARGE: 0
is: SBO:0000247
has only substance units: false
name: keratan sulfate I, degradation product 41
is: CHEBI:12936
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00143

metaR r0594
product: MODEL1310110004#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110004#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.2.1.3

metaM r1p c
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
is: CHEBI:57720
initial concentration: 1.0
type: Species
constant: false
is: HMDB01489
name: alpha-D-Ribose 1-phosphate
is: C00442
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR ELAIDt
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110004#
is described by: ECO:0000000
product: MODEL1310110004#
fast: false

metaR r1659
reactant: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
modifier: MODEL1310110004#
reversible: true
product: MODEL1310110004#
kinetic law: MODEL1310110004#

metaM dag hs e
is: CHEBI:18035
constant: false
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
initial concentration: 1.0
name: diglyceride
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_9417ca87_47cc_40e3_82c5_464595f93467
initial amount: NaN
is: O95470
name: SGPL1
is encoded by: hsa:8879
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

metaM dolp L r
is: CHEBI:57683
name: dolichyl phosphate(2-)
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_6bf8e797_5a0e_4f94_935b_4f497c56f825
has only substance units: false
is encoded by: hsa:4720
boundary condition: true
initial amount: NaN
constant: false
name: NDUFS2
type: Species
initial concentration: NaN
is: SBO:0000252
is: B7Z792

metaR r0246
reversible: false
modifier: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
product: MODEL1310110004#
reactant: MODEL1310110004#

metaR EX gbside hs LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: globoside (homo sapiens) exchange
type: Reaction

metaR LNSTLSr
reversible: false
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
fast: false
name: lanosterol synthase
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
type: Reaction
product: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.4.99.7

metaM hdcea c
boundary condition: false
is: CHEBI:32372
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB03229
name: Hexadecenoate (n-C16:1)
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
type: Species

metaM fmn e
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB01520
notes: FORMULA: C17H19N4O9P CHARGE: -2
name: FMN
has only substance units: false
is: C00061
boundary condition: false
is: CHEBI:58210

metaM retinol c
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00305
name: retinol
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: CHEBI:50211
has only substance units: false

metaR FAOXC181C161m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:1-->C16:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_772f5974_a01f_4573_ad77_78fee5790c8e
initial concentration: NaN
is encoded by: hsa:5158
type: Species
name: PDE6B
is: SBO:0000252
boundary condition: true
is: B7Z9T9
initial amount: NaN
has only substance units: false
constant: false

metaR r0245
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
modifier: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_d40b4d59_3234_4d14_a4bd_86cbc0108428
name: GUCY2D
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: Q02846
is encoded by: hsa:3000
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_d4bbe4a7_7966_4aee_ac38_e13c31c4fe99
boundary condition: true
initial amount: NaN
name: GLDC
initial concentration: NaN
is encoded by: hsa:2731
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: P23378

http://identifiers.org/biomodels.db/MODEL1310110004#_a290533b_16a4_4041_b767_c9489087d882
constant: false
boundary condition: true
name: _W87865_1_c
initial concentration: NaN
has only substance units: false
is encoded by: hsa:W87865
initial amount: NaN
is: SBO:0000252
type: Species

metaR GGH 5THFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reversible: false
reactant: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (5THF), extracellular
kinetic law: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_c71391b7_a300_4bed_a402_c51aa49a9a50
is: SBO:0000252
name: PRPS1
type: Species
constant: false
is encoded by: hsa:5631
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: P60891

metaM tststerone r
constant: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial amount: NaN
has only substance units: false
name: testosterone
initial concentration: 1.0
is: HMDB00234
type: Species
is: CHEBI:17347
is: SBO:0000247
boundary condition: false

metaM xoltriol c
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01457
type: Species
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
constant: false
has only substance units: false
is: CHEBI:16496
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol

http://identifiers.org/biomodels.db/MODEL1310110004#_688e4a3e_6494_4d58_857b_f31d777c977e
is: P09669
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1345
initial amount: NaN
name: COX6C
is: SBO:0000252
has only substance units: false
type: Species
constant: false

metaM ddcacoa m
boundary condition: false
is: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)
is: HMDB03571
initial concentration: 1.0
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:57375

metaM HC02207 e
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
is: CHEBI:27555
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
name: prostaglandin-c2
boundary condition: false
constant: false

metaR MTHFD2m
is described by: ECO:0000254
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
reversible: true
modifier: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.9

metaM datp m
is: HMDB01532
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: C00131
name: dATP
constant: false
is: CHEBI:61404

metaR r1653
product: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110004#

metaR GLUtr
is: SBO:0000185
product: MODEL1310110004#
is described by: ECO:0000000
reactant: MODEL1310110004#
fast: false
type: Reaction
kinetic law: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, needed to transport glu-L out of ER in conversion of leuktrC4-> leuktrD4 NJ
name: intracellular transport

metaR r2356
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110004#
fast: false
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_b1df0ba6_8318_45a0_bf9b_e70928e32295
is encoded by: hsa:3704
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: ITPA
is: Q9BY32
constant: false
initial amount: NaN

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR GGH 5THFl
kinetic law: MODEL1310110004#
fast: false
modifier: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
name: Gamma-glutamyl hydrolase (5THF), lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reversible: false
is described by: ECO:0000000
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.4.19.9

http://identifiers.org/biomodels.db/MODEL1310110004#_2df92883_364a_40a2_8ba6_c31bf4e95b84
is encoded by: hsa:U37519
initial amount: NaN
name: _U37519_1_e
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true
initial concentration: NaN

metaR r0139
is: SBO:0000176
product: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.2.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5

metaR r1877
reactant: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000185
name: Y+LAT2 Utilized transport

metaM m2mpdol U c
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
constant: false
is: CHEBI:28049

metaR ACALDt
kinetic law: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
product: MODEL1310110004#
fast: false
is described by: ECO:0000000
name: acetaldehyde reversible transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185

metaR CYTK13n
reactant: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
is described by: ECO:0000269
kinetic law: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dATP),nuclear
product: MODEL1310110004#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaR ALASm
reversible: false
modifier: MODEL1310110004#
product: MODEL1310110004#
fast: false
is: SBO:0000176
reactant: MODEL1310110004#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.3.1.29
is version of: http://identifiers.org/ec-code/2.3.1.37
type: Reaction
kinetic law: MODEL1310110004#
name: 5-aminolevulinate synthase
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD

metaR LEUKTRD4t
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000185
product: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
fast: false
name: leukotriene D4 transport
reversible: true
is described by: ECO:0000269

metaR L LACt2r
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
fast: false
type: Reaction
name: L-lactate reversible transport via proton symport
reactant: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
product: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000185

metaR NACHEX27ly
modifier: MODEL1310110004#
product: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
kinetic law: MODEL1310110004#
reversible: false
is: SBO:0000176
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction

metaR r1654
reactant: MODEL1310110004#
fast: false
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110004#
product: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction

metaR r2357
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
fast: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM HC02207 c
constant: false
initial amount: NaN
name: prostaglandin-c2
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
is: CHEBI:27555
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_12efc4ca_e336_417a_99c3_5f22c8893c84
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:57835
initial concentration: NaN
type: Species
has only substance units: false
name: SLC4A5
boundary condition: true

metaR EX tetdece1crn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecenoyl carnitine
type: Reaction

metaM dolp L c
type: Species
boundary condition: false
name: dolichyl phosphate(2-)
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57683
initial concentration: 1.0
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110

metaM datp n
type: Species
is: CHEBI:61404
is: SBO:0000247
is: HMDB01532
has only substance units: false
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: C00131
initial amount: NaN
constant: false
name: dATP
boundary condition: false
initial concentration: 1.0

metaM HC00342 m
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
type: Species
name: cis-aconitate(3-)
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial amount: NaN
is: CHEBI:16383

metaR ATPtm
is: SBO:0000185
reversible: false
type: Reaction
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (291.1) or (293.1) or (292.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
product: MODEL1310110004#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110004#
name: ADP/ATP transporter, mitochondrial
kinetic law: MODEL1310110004#

metaR RE2972M
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.67
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
name: RE2972

metaM mmcoa R m
boundary condition: false
is: HMDB01269
has only substance units: false
initial concentration: 1.0
name: (R)-methylmalonyl-CoA(5-)
is: SBO:0000247
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
type: Species
is: CHEBI:57326
constant: false
initial amount: NaN

metaM 2mop m
name: 2-methyl-3-oxopropanoate
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial amount: NaN
is: CHEBI:57700
has only substance units: false
boundary condition: false
is: HMDB01172
type: Species

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_c
constant: false
is: CHEBI:18287
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
initial concentration: 1.0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
is: HMDB00174

http://identifiers.org/biomodels.db/MODEL1310110004#_05d13797_0378_4610_beef_548e00b0f773
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3284
has only substance units: false
initial amount: NaN
name: HSD3B2
is: P26439

metaM prostgh2 e
has only substance units: false
is: HMDB01381
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:57405
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
name: prostaglandin H2(1-)

metaR r2354
type: Reaction
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110004#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110004#
product: MODEL1310110004#

metaR r1655
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
fast: false
modifier: MODEL1310110004#
type: Reaction

metaM pristcoa c
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:51341
constant: false
name: pristanoyl coa
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_3ad41764_0699_4ab3_bddd_192b8fba71d1
has only substance units: false
boundary condition: true
is encoded by: hsa:8897
initial concentration: NaN
name: MTMR3
constant: false
initial amount: NaN
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_86347562_43a9_4295_8a6b_041e0ece0b44
name: PIP4K2A
type: Species
is encoded by: hsa:5305
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is: P48426
has only substance units: false
boundary condition: true

metaM pheacgln e
initial amount: NaN
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: SBO:0000247
is: CHEBI:58310
has only substance units: false
type: Species
constant: false
boundary condition: false
is: HMDB06344
initial concentration: 1.0
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate

http://identifiers.org/biomodels.db/MODEL1310110004#_d53fb3dc_a51b_49a1_b0f5_d748faf28d0a
is: Q9BVG9
boundary condition: true
is encoded by: hsa:81490
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
name: PTDSS2

metaR RE3326M
type: Reaction
notes: GENE_ASSOCIATION: (594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:2699399,PMID:9665099 NOTES:
is: SBO:0000176
reactant: MODEL1310110004#
product: MODEL1310110004#
fast: false
name: RE3326
reversible: true
modifier: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.2.4.4

metaR DTMPK
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: true
name: dTMP kinase
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.9

http://identifiers.org/biomodels.db/MODEL1310110004#_7d4866aa_7cfc_4a39_9dd7_71a77541e816
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:10554
constant: false
is: Q99943
boundary condition: true
name: AGPAT1
is: SBO:0000252
type: Species

metaM 3htdcoa m
is: HMDB02288
constant: false
name: (S)-3-Hydroxytetradecanoyl-CoA
notes: FORMULA: C35H58N7O18P3S CHARGE: -4
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0

metaM HC02024 r
notes: FORMULA: C45H76O2 CHARGE: 0 INCHI: InChI=1S/C45H76O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h11-12,14-15,26,35-36,38-42H,7-10,13,16-25,27-34H2,1-6H3/b12-11-,15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
is: CHEBI:41509
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
name: Cholesterol-ester-lin

metaR r2355
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110004#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110004#
product: MODEL1310110004#

metaM 4abut n
name: 4-Aminobutanoate
is: C00334
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0
type: Species
is: SBO:0000247
is: HMDB00112
boundary condition: false
has only substance units: false
constant: false

metaM c101crn c
type: Species
is: SBO:0000247
name: decenoyl carnitine
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C17H31NO4 CHARGE: 0
is: HMDB13205
constant: false

metaM hco3 c
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:17544
initial amount: NaN
type: Species
is: HMDB00595
initial concentration: 1.0
has only substance units: false
is: C00288
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
name: Bicarbonate

metaR r1656
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
modifier: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110004#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110004#_4893be35_95a0_4611_90ff_f38a09fd5b62
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10587
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
name: TXNRD2
has only substance units: false

metaM ksii core2 deg4 l
initial concentration: 1.0
is: CHEBI:57455
is: SBO:0000247
notes: FORMULA: C58H95N5O43SX CHARGE: -1
is: HMDB01354
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 4

metaR GGH 10FTHF7GLUe
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.19.9
reactant: MODEL1310110004#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_e
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
is: C00095
is: SBO:0000247
is: HMDB00660
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:15824
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_f0f63e08_8772_4755_b684_be64c0bdc7a6
initial concentration: NaN
name: AMT
is: P48728
is: SBO:0000252
is encoded by: hsa:275
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_6d160e3e_12f8_4260_a7b6_eaa940db7640
is: SBO:0000252
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:2584
is: P51570
initial concentration: NaN
name: GALK1

metaM 6pgl r
is: SBO:0000247
is: CHEBI:57955
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB01127
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_1d4bee14_a794_4ec0_8113_af250cd6353d
initial concentration: NaN
has only substance units: false
is: P35557
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
name: GCK
boundary condition: true
is encoded by: hsa:2645

metaM octd11ecoa c
constant: false
name: 11-octadecenoylcoa
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5280771
type: Species
boundary condition: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_87ab7b87_992c_4ef7_9bac_15fd4ccb334a
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
name: HEXB
is encoded by: hsa:3074
is: P07686
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_acglcgalacglcgal14acglcgalgluside_hs_g
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
boundary condition: false
name: (Gal)3 (Glc)1 (GlcNAc)3 (Cer)1
constant: false
type: Species
is: SBO:0000247
is: CHEBI:26174
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_d53e201c_1d64_4472_8961_3548e1be4598
is: Q9NWU1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: OXSM
is encoded by: hsa:54995
constant: false
boundary condition: true
type: Species

metaM amp c
is: C00020
is: HMDB00045
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2
name: AMP
is: SBO:0000247
constant: false
is: CHEBI:3322

metaR GLCSGLT1le
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-glucose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

metaM pheacgln c
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial amount: NaN
is: CHEBI:58310
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
constant: false
is: HMDB06344
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM 4mlacac c
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
initial amount: NaN
initial concentration: 1.0
name: 4-maleylacetoacetate
type: Species
boundary condition: false
constant: false
is: CHEBI:17105
is: HMDB02052
is: SBO:0000247
has only substance units: false

metaR 3HBCOAHLm
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
product: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000176
fast: false
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
is described by: ECO:0000000
kinetic law: MODEL1310110004#

metaR DCYTDn
is described by: ECO:0000254
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: false
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.5.4.5
fast: false
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
is: SBO:0000176
type: Reaction
name: deoxycytidine deaminase, nuclear

metaR BAAT2x
name: bile acid Coenzyme A: amino acid N-acyltransferase
kinetic law: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
reversible: false
fast: false
product: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction

metaM 2mbcoa m
is: HMDB01041
type: Species
is: CHEBI:57336
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: 2-methylbutanoyl-CoA(4-)
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
constant: false
has only substance units: false

metaR MTHFD
name: methylenetetrahydrofolate dehydrogenase (NADP)
modifier: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.5
kinetic law: MODEL1310110004#
is described by: ECO:0000134
fast: false
reversible: true

metaM ksii core4 deg1 l
initial amount: NaN
name: keratan sulfate II (core 4-linked), degradation product 1
constant: false
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
is: CHEBI:57737
is: HMDB00868
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false

metaR r1650
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
type: Species
is: SBO:0000247
is: HMDB00174
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
is: CHEBI:18287

metaM dgchol x
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:36252
is: SBO:0000247
name: glycochenodeoxycholate
is: HMDB00637
type: Species
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
has only substance units: false

metaM hco3 e
initial concentration: 1.0
is: HMDB00595
has only substance units: false
constant: false
initial amount: NaN
is: C00288
is: SBO:0000247
name: Bicarbonate
type: Species
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: CHEBI:17544
boundary condition: false

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM ddcacoa x
is: HMDB03571
type: Species
is: CHEBI:57375
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)
is: SBO:0000247
has only substance units: false

metaR DRIBt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110004#
name: deoxyribose transport via diffusion
reversible: true
product: MODEL1310110004#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110004#

metaM glc D e
boundary condition: false
name: D-glucose
type: Species
initial amount: NaN
is: CHEBI:4167
constant: false
is: HMDB00122
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040

metaR MTHFC
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.5
is described by: ECO:0000134
type: Reaction
product: MODEL1310110004#
is: SBO:0000176
modifier: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
name: methenyltetrahydrofolate cyclohydrolase
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

metaM ksii core2 pre1 g
name: keratan sulfate II biosynthesis, precursor 1
constant: false
is: CHEBI:28067
initial amount: NaN
notes: FORMULA: C33H53N3O23X CHARGE: -1
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

metaM cysam c
is: SBO:0000247
initial amount: NaN
name: cysteaminium
is: CHEBI:58029
initial concentration: 1.0
is: HMDB02991
constant: false
type: Species
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
boundary condition: false
has only substance units: false

metaR r1651
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110004#
fast: false
product: MODEL1310110004#
modifier: MODEL1310110004#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_c3e68019_8326_4ae2_aa62_105d81413033
constant: false
is: SBO:0000252
is encoded by: hsa:8883
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: NAE1
has only substance units: false
is: A8MU28

metaR RE0453M
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110004#
type: Reaction
name: RE0453
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
modifier: MODEL1310110004#
reversible: true

metaM 4fumacac c
type: Species
is: HMDB01268
boundary condition: false
initial amount: NaN
name: 4-fumarylacetoacetate(2-)
initial concentration: 1.0
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
constant: false
is: CHEBI:18034
is: SBO:0000247
has only substance units: false

metaR r2358
fast: false
reactant: MODEL1310110004#
is described by: ECO:0000000
product: MODEL1310110004#
is: SBO:0000185
kinetic law: MODEL1310110004#
reversible: true
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_78743ebb_fa82_4db9_bf57_4c2525187aa0
is encoded by: hsa:349565
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: Q96T66
has only substance units: false
constant: false
type: Species
boundary condition: true
name: NMNAT3

metaR EX glysar LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylsarcosine
type: Reaction

metaM 34dhoxmand c
name: 3,4-Dihydroxymandelate
has only substance units: false
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
is: HMDB01866
is: CHEBI:27637
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR H2Oter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110004#
name: H2O endoplasmic reticulum transport

metaR PSSA1 hs
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.8.29
fast: false
name: Phosphatidylserine synthase homo sapiens
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
is: SBO:0000176
type: Reaction
product: MODEL1310110004#
kinetic law: MODEL1310110004#

metaR r1879
reversible: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185
modifier: MODEL1310110004#
name: Y+LAT2 Utilized transport

metaR FAOXC18C18OHm
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_891969e2_93f5_4283_8b07_fb347983471c
boundary condition: true
constant: false
name: ATP5G3
initial amount: NaN
type: Species
has only substance units: false
is: P48201
is encoded by: hsa:518
is: SBO:0000252
initial concentration: NaN

metaM arachcrn c
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB06460
initial amount: NaN
name: arachidyl carnitine
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3

metaR MACACI
type: Reaction
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.18
fast: false
product: MODEL1310110004#
name: maleylacetoacetate isomerase
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: false
reactant: MODEL1310110004#

metaM ksi pre25 g
initial amount: NaN
is: SBO:0000247
constant: false
is: C00130
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
has only substance units: false
is: CHEBI:58053
boundary condition: false
is: HMDB00175
initial concentration: 1.0
type: Species
name: keratan sulfate I biosynthesis, precursor 25

metaR EX nrpphrsf LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate derivative of norepinephrine exchange
type: Reaction

metaM dmnoncoa c
constant: false
is: HMDB11604
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 4,8 dimethylnonanoyl-CoA
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
has only substance units: false

metaR r1652
product: MODEL1310110004#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110004#
fast: false
type: Reaction

metaR r2359
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reversible: true
fast: false
reactant: MODEL1310110004#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110004#_7922d2e0_f70a_48db_99b8_07cb0a006a7d
initial concentration: NaN
initial amount: NaN
type: Species
name: _AA788780_1_c
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AA788780
constant: false
has only substance units: false

metaR r0475
type: Reaction
reversible: true
product: MODEL1310110004#
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaR RE0453N
type: Reaction
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
modifier: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
is: SBO:0000176
name: RE0453
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_d247d367_c29d_4b2c_860f_0eb4f3c02aff
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: SLC16A7
constant: false
is encoded by: hsa:9194
is: Q8NEM3
initial amount: NaN

metaM prostgh2 c
is: SBO:0000247
constant: false
is: HMDB01381
initial concentration: 1.0
has only substance units: false
is: CHEBI:57405
type: Species
boundary condition: false
initial amount: NaN
name: prostaglandin H2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427

metaM xol7ah3 c
is: SBO:0000247
is: HMDB12455
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:28540
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,26-triol
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_07bae118_d2ca_4514_b701_2027d6092175
type: Species
initial concentration: NaN
name: LTC4S
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q16873
is encoded by: hsa:4056
boundary condition: true

metaM glc D c
type: Species
is: CHEBI:4167
initial amount: NaN
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false
is: HMDB00122
initial concentration: 1.0
is: SBO:0000247
name: D-glucose
boundary condition: false

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR ENGASE2ly
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
name: endo-beta-N-acetylglucosaminidase, lysosomal
product: MODEL1310110004#
is described by: ECO:0000000
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#

metaM HC00342 c
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
name: cis-aconitate(3-)
is: CHEBI:16383
boundary condition: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_5473929d_7992_4de3_a1a9_7991809779bb
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: TXNRD1
constant: false
is encoded by: hsa:7296
is: SBO:0000252

metaM pro D e
is: CHEBI:16313
type: Species
boundary condition: false
is: HMDB03411
initial amount: NaN
name: D-proline
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_7065208f_d0f5_4909_909b_92e8744f6b40
initial amount: NaN
name: ALDH3B1
type: Species
constant: false
has only substance units: false
is: P43353
boundary condition: true
initial concentration: NaN
is encoded by: hsa:221
is: SBO:0000252

metaM dolmanp U c
is: CHEBI:15809
is: SBO:0000247
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
name: Dolichyl phosphate D-mannose, human uterine homolog
type: Species

metaR CHOLESTle
is: SBO:0000176
type: Reaction
product: MODEL1310110004#
reversible: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: hydrolysis of cholesterol ester by cholesterol esterase
is version of: http://identifiers.org/ec-code/3.1.1.13
modifier: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
is described by: ECO:0000134

metaM ascb L c
is: HMDB00044
is: CHEBI:38290
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
name: L-ascorbate

http://identifiers.org/biomodels.db/MODEL1310110004#_7f8fa912_0ec8_4970_855b_dc6ded015067
constant: false
boundary condition: true
is encoded by: hsa:83697
has only substance units: false
is: SBO:0000252
is: E9PDK1
name: SLC4A9
type: Species
initial amount: NaN
initial concentration: NaN

metaR G14T11g
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
type: Reaction
reactant: MODEL1310110004#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
kinetic law: MODEL1310110004#

metaM xyl D e
is: SBO:0000247
has only substance units: false
is: CHEBI:15936
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
boundary condition: false
name: aldehydo-D-xylose

metaM 25hvitd3 c
is: SBO:0000247
name: calcidiol
is: CHEBI:17933
has only substance units: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
boundary condition: false
is: HMDB03550
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false

metaR IPDDIx
modifier: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
kinetic law: MODEL1310110004#
reversible: true
fast: false
name: isopentenyl-diphosphate D-isomerase
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.3.2

http://identifiers.org/biomodels.db/MODEL1310110004#_4dadd105_fdca_4a51_9062_b9fa0660b811
type: Species
initial concentration: NaN
name: SLC5A5
is encoded by: hsa:6528
is: Q92911
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_a7fb06ab_ef98_4cd7_b17d_159d6b495d30
name: EPX
has only substance units: false
is: P11678
constant: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:8288
is: SBO:0000252
initial concentration: NaN

metaM acnacngalgbside hs e
is: SBO:0000247
is: HMDB00223
type: Species
initial amount: NaN
name: disialyl galactosylgloboside
constant: false
is: C00036
is: CHEBI:3338
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
has only substance units: false

metaM mi145p c
is: HMDB01498
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
has only substance units: false
is: SBO:0000247
is: CHEBI:203600
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_873318ae_589e_4996_b283_be388beeace1
is encoded by: hsa:51227
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
name: PIGP

http://identifiers.org/biomodels.db/MODEL1310110004#_3966b3d4_2be6_4aef_8874_128dff6a1958
is encoded by: hsa:51557
name: LGSN
type: Species
constant: false
boundary condition: true
is: Q5TDP6
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR r0153
is: SBO:0000176
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
is described by: ECO:0000000
product: MODEL1310110004#
reversible: false
type: Reaction
modifier: MODEL1310110004#
name: CTP:pyruvate O2-phosphotransferase EC:2.7.1.40
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110004#_898f7694_00c5_4fe9_8d88_3fda37901ffe
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P14618
type: Species
is encoded by: hsa:5315
name: PKM2

metaM gdpmann c
is: SBO:0000247
name: GDP-alpha-D-mannose(2-)
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: HMDB01163
is: CHEBI:57527
has only substance units: false
type: Species

metaM hs deg12 l
constant: false
is: HMDB01352
name: heparan sulfate, degradation product 12
is: CHEBI:17180
initial amount: NaN
boundary condition: false
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR r2338
is: SBO:0000185
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
reactant: MODEL1310110004#
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
fast: false
reversible: true
is described by: ECO:0000000

metaR r0472
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
product: MODEL1310110004#
type: Reaction
is: SBO:0000176
fast: false
reversible: true
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110004#
is described by: ECO:0000000

metaR r0686
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reversible: true
reactant: MODEL1310110004#
type: Reaction
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.2.2
modifier: MODEL1310110004#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12

metaM thcholstoic x
is: HMDB03873
has only substance units: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
type: Species
is: CHEBI:18402
boundary condition: false

metaM ptrc c
boundary condition: false
is: CHEBI:326268
initial concentration: 1.0
is: HMDB01414
type: Species
name: Putrescine
has only substance units: false
constant: false
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
initial amount: NaN
is: SBO:0000247
is: C00134

metaM 2hb e
is: SBO:0000247
is: CHEBI:1148
initial concentration: 1.0
is: HMDB00008
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
name: 2-Hydroxybutyrate
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984

http://identifiers.org/biomodels.db/MODEL1310110004#_afe2ac2f_f7d5_44f5_83b8_8f7def69827f
is: Q49AT3
constant: false
initial amount: NaN
is encoded by: hsa:8706
is: SBO:0000252
has only substance units: false
type: Species
name: B3GALNT1
initial concentration: NaN
boundary condition: true

metaM ascb L e
name: L-ascorbate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:38290
is: HMDB00044
type: Species

metaM adrncoa c
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205480
constant: false
initial concentration: 1.0
is: C16170
name: adrenyl coenzyme A
boundary condition: false

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaM dgchol c
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: SBO:0000247
name: glycochenodeoxycholate
is: CHEBI:36252
has only substance units: false
is: HMDB00637

metaR F1PGT
reversible: true
reactant: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.30
fast: false
is described by: ECO:0000000
name: fucose-1-phosphate guanylyltransferase
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#

metaM 25hvitd3 e
type: Species
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17933
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3/b21-11+,22-12-/t20-,23+,24-,25+,27-/m1/s1
initial concentration: 1.0
name: calcidiol
is: HMDB03550

metaM CE5132 c
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
initial amount: NaN
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:57923
constant: false

metaM 3mox4hpac m
is: HMDB05175
initial concentration: 1.0
has only substance units: false
is: CHEBI:28111
boundary condition: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde

metaM acnacngalgbside hs c
is: C00036
boundary condition: false
is: CHEBI:3338
has only substance units: false
initial amount: NaN
is: HMDB00223
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
initial concentration: 1.0
type: Species
is: SBO:0000247
name: disialyl galactosylgloboside
constant: false

metaR FAOXC10C10OHm
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->OHC10)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_d7e2ae9e_7f8c_4de4_b382_12f7e5aa65d4
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: _AA526438_1_m
has only substance units: false
initial amount: NaN
is encoded by: hsa:AA526438
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_metaM_fucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
initial amount: NaN
is: CHEBI:61648
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
initial concentration: 1.0
has only substance units: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
boundary condition: false
constant: false
is: SBO:0000247
type: Species

metaR DOLPGT1 Uer
fast: false
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
is: SBO:0000176
type: Reaction
reversible: false
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.267
is described by: ECO:0000000
product: MODEL1310110004#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
modifier: MODEL1310110004#

metaR r0688
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
is: SBO:0000176
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR r0474
type: Reaction
product: MODEL1310110004#
is: SBO:0000176
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
fast: false
reversible: true
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_dd66ecca_40cc_4419_a22a_044dec3567f5
initial concentration: NaN
boundary condition: true
is encoded by: hsa:978
constant: false
has only substance units: false
initial amount: NaN
type: Species
name: CDA
is: SBO:0000252
is: P32320

http://identifiers.org/biomodels.db/MODEL1310110004#_421aacec_be9d_4a09_88e4_c485dfe1b54c
boundary condition: true
type: Species
is: Q16842
name: ST3GAL2
constant: false
is encoded by: hsa:6483
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_345d3541_b390_43d1_ba51_146128804f4c
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:5152
name: PDE9A
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_27eea6f2_e67e_4a97_b8ee_afb1a2781910
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: PDE9A
initial concentration: NaN
is encoded by: hsa:5152

metaM ptrc e
type: Species
name: Putrescine
is: HMDB01414
boundary condition: false
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: CHEBI:326268
is: SBO:0000247
is: C00134
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134

metaR ADK1
product: MODEL1310110004#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
reversible: true
name: adenylate kinase
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176

metaR r0156
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
modifier: MODEL1310110004#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15

http://identifiers.org/biomodels.db/MODEL1310110004#_20c06919_09b3_42f9_bf59_2316a6d1c4e4
is: P28330
is encoded by: hsa:33
is: SBO:0000252
type: Species
name: ACADL
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true

metaR S6T8g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110004#
reversible: false
is: SBO:0000176
fast: false
reactant: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#

metaR DCK1n
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reactant: MODEL1310110004#
reversible: true
modifier: MODEL1310110004#
product: MODEL1310110004#
fast: false
name: Deoxycytidine kinase, nuclear (ATP)
is version of: http://identifiers.org/ec-code/2.7.1.74
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)

metaR S6TASE11ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110004#
is described by: ECO:0000000
reactant: MODEL1310110004#
type: Reaction
reversible: true
product: MODEL1310110004#
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110004#
fast: false

metaR GTHPm
name: glutathione peroxidase, mitochondria
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is version of: http://identifiers.org/ec-code/1.11.1.15
is: SBO:0000176
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.11.1.12
fast: false
type: Reaction
kinetic law: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_e113f575_932c_4ac3_80bf_04a20f4007d1
is: Q7LG56
is encoded by: hsa:50484
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: RRM2B
has only substance units: false
type: Species
initial concentration: NaN

metaR RPEc
kinetic law: MODEL1310110004#
name: ribulose 5-phosphate 3-epimerase
is: SBO:0000176
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
type: Reaction
fast: false
product: MODEL1310110004#
reversible: true
is described by: ECO:0000134

metaM na1 c
notes: FORMULA: Na CHARGE: 1
constant: false
is: C01330
has only substance units: false
name: Sodium
initial amount: NaN
is: CHEBI:4541
initial concentration: 1.0
is: HMDB00588
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_fbcdce51_e629_4c2d_a49b_44ea75b4d9f7
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:2597
initial amount: NaN
name: GAPDH
boundary condition: true
is: E7EUT4

metaM strdnccoa x
constant: false
is: C16163
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
boundary condition: false
is: SBO:0000247
is: HMDB06519
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: stearidonyl coenzyme A
type: Species
is: http://identifiers.org/pubchem.compound/47205473

metaR HYXNt
reactant: MODEL1310110004#
is: SBO:0000185
name: Hypoxanthine transport
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
reversible: true
type: Reaction

metaM mlthf m
initial concentration: 1.0
boundary condition: false
is: CHEBI:15636
type: Species
is: C00143
name: 5,10-Methylenetetrahydrofolate
constant: false
is: HMDB01533
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143

http://identifiers.org/biomodels.db/MODEL1310110004#_aa5d2023_92ef_49a0_bbba_da251624661a
has only substance units: false
type: Species
constant: false
name: FH
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2271
boundary condition: true
is: P07954

metaM nadp x
initial amount: NaN
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate
is: C00006
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: HMDB00217
is: CHEBI:58349

http://identifiers.org/biomodels.db/MODEL1310110004#_98c15e96_2640_4d50_a1e3_2e88d1682e64
type: Species
is encoded by: hsa:4714
name: NDUFB8
initial concentration: NaN
is: SBO:0000252
is: O95169
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

metaR r0157
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
product: MODEL1310110004#
modifier: MODEL1310110004#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.2

metaM pro D c
constant: false
is: CHEBI:16313
name: D-proline
initial concentration: 1.0
type: Species
is: HMDB03411
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_22d2cd2c_2b52_48bc_a930_acc8e4beadca
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:57282
type: Species
is: B7Z1R0
initial amount: NaN
name: SLC4A10
initial concentration: NaN

metaR EX met L LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Methionine exchange
type: Reaction

metaR r0683
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
kinetic law: MODEL1310110004#
reversible: false
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaR ADK3
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
product: MODEL1310110004#
is described by: ECO:0000269
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
fast: false
is: SBO:0000176
reversible: true
name: adentylate kinase (GTP)

metaR L LACt4r
name: L-lactate reversible transport via sodium symport
reactant: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
reversible: true
kinetic law: MODEL1310110004#
is described by: ECO:0000000
product: MODEL1310110004#
type: Reaction
fast: false

metaM c101crn e
has only substance units: false
is: SBO:0000247
name: decenoyl carnitine
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: HMDB13205
notes: FORMULA: C17H31NO4 CHARGE: 0

metaM xyl D c
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
type: Species
constant: false
initial concentration: 1.0
name: aldehydo-D-xylose
has only substance units: false
is: CHEBI:15936
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM glutcoa c
is: HMDB01339
name: glutaryl-CoA(5-)
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species

metaM cspg c l
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: HMDB02183
constant: false
is: CHEBI:36005
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan
has only substance units: false
initial amount: NaN

metaM hexe3coa m
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: HMDB06522
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
initial amount: NaN
name: 3-hexenoylcoa
boundary condition: false
is: SBO:0000247

metaR HISCAT1
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR PHYCBOXL
is version of: http://identifiers.org/ec-code/4.1.1.28
type: Reaction
product: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
name: L-Phenylalanine carboxy-lyase
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
modifier: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
reversible: false
is described by: ECO:0000212

metaM acnacngalgbside hs g
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
name: disialyl galactosylgloboside
is: CHEBI:3338
is: C00036
type: Species
is: HMDB00223
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
boundary condition: false

metaR GALSGLT1le
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-Galactose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

metaR LEUKTRD4tr
type: Reaction
kinetic law: MODEL1310110004#
product: MODEL1310110004#
name: leukotriene intracellular transport
is: SBO:0000185
reversible: true
reactant: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
is described by: ECO:0000000

metaR OMPDC
reactant: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
reversible: false
name: orotidine-5'-phosphate decarboxylase
modifier: MODEL1310110004#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.10
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
type: Reaction

metaM na1 e
notes: FORMULA: Na CHARGE: 1
is: C01330
initial amount: NaN
is: CHEBI:4541
name: Sodium
has only substance units: false
is: HMDB00588
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
constant: false

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaM aacoa x
type: Species
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false
initial concentration: 1.0
is: HMDB01484
initial amount: NaN
name: acetoacetyl-CoA(4-)
is: SBO:0000247
has only substance units: false
is: CHEBI:57286
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_ec2b22b6_3a6e_4c2c_a127_e76c44bed907
name: ITPKA
type: Species
is: P23677
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:3706

metaM lgnccoa c
name: lignocericyl coenzyme A
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB06526
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false

metaR UMPK4n
is: SBO:0000176
modifier: MODEL1310110004#
name: UMP kinase (GTP),nuclear
fast: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110004#_29e8bba2_80a8_4406_a42b_943f2030be77
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
constant: false
boundary condition: true
name: DPAGT1
initial amount: NaN
is encoded by: hsa:1798
is: Q9H3H5

metaM octe5coa x
has only substance units: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 5-octenoylcoa
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_c16d82e2_7f15_4baf_9ef7_a65e4b6c071b
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
name: UGT1A8
is: Q5DSZ6
has only substance units: false
is encoded by: hsa:54576
initial amount: NaN

metaR O2St
reactant: MODEL1310110004#
product: MODEL1310110004#
reversible: true
type: Reaction
name: superoxide anion transport via diffusion (extracellular)
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR GLNtN1
is described by: ECO:0000269
product: MODEL1310110004#
modifier: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
fast: false
kinetic law: MODEL1310110004#
name: Glutamine transport (Na, H coupled)
reversible: true
is: SBO:0000185
type: Reaction

metaM lneldccoa c
initial amount: NaN
is: SBO:0000247
is: HMDB06521
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
boundary condition: false
constant: false
has only substance units: false
type: Species
is: http://identifiers.org/pubchem.compound/9543677
initial concentration: 1.0
name: linoelaidyl coenzyme A

metaM docohexcoa m
type: Species
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
name: 2,4,7,10,13,16-docosahexenoylcoa
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_ef0d5fb0_1db9_4501_af53_efb2b9e42f8c
constant: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2876
has only substance units: false
name: GPX1

metaM glutcoa m
is: CHEBI:57378
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: glutaryl-CoA(5-)
constant: false
is: HMDB01339
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527

metaM tststerone e
boundary condition: false
is: HMDB00234
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
name: testosterone
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial concentration: 1.0
has only substance units: false
is: CHEBI:17347

metaR r0774
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110004#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110004#
reactant: MODEL1310110004#

metaR LEUPHELAT2tc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaR VD3
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
is described by: ECO:0000134
type: Reaction
name: Vitamin D3 formation
is: SBO:0000176
reactant: MODEL1310110004#
reversible: true
fast: false

metaR CO2tm
type: Reaction
is described by: ECO:0000000
name: CO2 transport (diffusion), mitochondrial
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
product: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_40a011d5_c9cd_41b5_94f0_9bfeef5c9b40
initial concentration: NaN
is: Q13454
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:7991
has only substance units: false
type: Species
boundary condition: true
name: TUSC3

http://identifiers.org/biomodels.db/MODEL1310110004#_3616931f_f896_44d5_b08e_7022c897170c
is encoded by: hsa:1340
is encoded by: hsa:4514
has part: Q02221
has part: Q6FGA0
has part: Q6YFQ2
is encoded by: hsa:1339
is encoded by: hsa:4512
has part: P00414
has part: P15954
is encoded by: hsa:1347
is encoded by: hsa:1337
has part: P24311
is encoded by: hsa:1350
initial amount: NaN
is encoded by: hsa:9167
has part: H0UI06
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P14854
has part: P12074
is encoded by: hsa:1346
is encoded by: hsa:4513
boundary condition: true
is encoded by: hsa:125965
is encoded by: hsa:1329
is: SBO:0000297
has part: P13073
has part: Q7GXY8
is encoded by: hsa:84701
has part: P20674
is encoded by: hsa:9377
is encoded by: hsa:170712
has part: Q53YB7
has only substance units: false
initial concentration: NaN
is encoded by: hsa:341947
has part: Q96KJ9
has part: Q53XN1
has part: Q8TF08
is encoded by: hsa:1345
is encoded by: hsa:1327
constant: false
is encoded by: hsa:1351
type: Species
has part: P09669
has part: Q7Z4L0
has part: Q7GXZ8
is encoded by: hsa:1349
has part: P24310

metaR S6TASE17ly
is: SBO:0000176
product: MODEL1310110004#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110004#
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110004#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_ffcb6a1f_2c3e_44f1_8e0e_40b54f70fecf
is encoded by: hsa:6522
constant: false
is: SBO:0000252
boundary condition: true
type: Species
name: SLC4A2
initial concentration: NaN
is: F8W682
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_da1cd097_5ba3_4e7b_8303_e82d4c66a25f
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: Q96C36
is encoded by: hsa:29920
name: PYCR2
is: SBO:0000252

metaM 3hdececrn e
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02068
type: Species
constant: false
is: SBO:0000247
name: 3-hydroxyhexadecenoylcarnitine
notes: FORMULA: C23H43NO5 CHARGE: 0
boundary condition: false

metaR r0360
modifier: MODEL1310110004#
fast: false
is described by: ECO:0000000
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reversible: false
type: Reaction
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is: SBO:0000176
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.2.1.16
reactant: MODEL1310110004#

metaM strdnccoa m
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205473
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
is: C16163
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: stearidonyl coenzyme A
initial amount: NaN
type: Species
is: HMDB06519

metaR CO2tp
reversible: true
name: CO2 peroxisomal transport
reactant: MODEL1310110004#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000000
fast: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR r0267
reactant: MODEL1310110004#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.9
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
kinetic law: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
fast: false
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is: SBO:0000176
reversible: true
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_4abeebc4_e998_463f_b9f6_f915a1f7eca9
constant: false
is encoded by: hsa:517
is: SBO:0000297
boundary condition: true
initial amount: NaN
has part: Q06055
has only substance units: false
type: Species
initial concentration: NaN
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2

metaM 3ivcoa c
boundary condition: false
is: HMDB06870
initial amount: NaN
initial concentration: 1.0
type: Species
name: 3-hydroxyisovalerylcoa
is: http://identifiers.org/pubchem.compound/11966188
is: C05998
is: SBO:0000247
constant: false
notes: FORMULA: C26H40N7O18P3S CHARGE: -4
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_4d1a89ed_44db_4498_b8f4_064a76cb754c
constant: false
is: SBO:0000252
is: Q86YU0
is encoded by: hsa:766
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: CA7

http://identifiers.org/biomodels.db/MODEL1310110004#_a5abc331_5085_4b4c_823e_d59910970dcf
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q709F0
name: ACAD11
type: Species
initial amount: NaN
is encoded by: hsa:84129

metaR C5DCe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_888c286a_0754_4286_bcb0_7347e0a16f06
is: SBO:0000252
initial amount: NaN
type: Species
is: Q02127
is encoded by: hsa:1723
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
name: DHODH

http://identifiers.org/biomodels.db/MODEL1310110004#_3315fb75_ac69_447a_88a1_8a056ff236a4
initial amount: NaN
is encoded by: hsa:375056
is: SBO:0000252
name: MIA3
is: Q5JRA6
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species

metaM ksi deg2 l
constant: false
boundary condition: false
is: HMDB00573
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30825
name: keratan sulfate I, degradation product 2

metaM glc D r
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00122
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:4167
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false

metaR ETOHt
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
name: ethanol reversible transport
product: MODEL1310110004#
type: Reaction
reactant: MODEL1310110004#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_a40730ed_c1aa_48ba_8244_951beb0ad108
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: _AA278423_1_m
boundary condition: true
type: Species
is encoded by: hsa:AA278423
initial amount: NaN

metaM tststerone c
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: testosterone
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00234
is: CHEBI:17347

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_d4555b2b_9736_41c4_aff0_b3f82a04cb79
initial amount: NaN
type: Species
is: Q96I99
is: SBO:0000252
is encoded by: hsa:8801
initial concentration: NaN
name: SUCLG2
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_ef23351c_e3ea_4549_b9d7_014b467f39f3
is encoded by: hsa:51227
has only substance units: false
constant: false
type: Species
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
initial amount: NaN
is: SBO:0000297
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_e082b2c0_1f81_4133_9823_b4fb3a63d1fa
type: Species
is: Q76EJ3
is: SBO:0000252
name: SLC35D2
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:11046
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_766ff18a_8a66_4aca_8562_de5275044201
is: SBO:0000252
constant: false
type: Species
is: D3DWC4
is encoded by: hsa:259230
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: SGMS1
has only substance units: false

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_metaR_FUCFUCFUCGALACGLC13GALACGLCGAL14ACGLCGALGLUSIDEte
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110004#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reversible: true
name: blood group intracellular transport
reactant: MODEL1310110004#
product: MODEL1310110004#

metaR r0268
is version of: http://identifiers.org/ec-code/3.1.3.2
type: Reaction
is: SBO:0000176
reactant: MODEL1310110004#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.1
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
modifier: MODEL1310110004#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
fast: false

metaR FMNAT
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.7.2
fast: false
name: FMN adenylyltransferase
type: Reaction
modifier: MODEL1310110004#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
reversible: false
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_bcfc5ffc_ff7d_447d_bb69_45db3c551627
initial amount: NaN
is: Q9HC58
has only substance units: false
type: Species
initial concentration: NaN
name: SLC24A3
constant: false
is encoded by: hsa:57419
boundary condition: true
is: SBO:0000252

metaR r0575
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.1.48
fast: false
modifier: MODEL1310110004#
reversible: true
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
type: Reaction

metaR C10CRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decanoyl carnitine into extra cellular space
type: Reaction

metaR HEXDIACTD
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

metaM malthx e
is: http://identifiers.org/pubchem.compound/5041
name: Maltohexaose
boundary condition: false
is: SBO:0000247
is: C01936
has only substance units: false
constant: false
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
initial concentration: 1.0
type: Species
initial amount: NaN

metaR FUT15g
modifier: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
product: MODEL1310110004#
is described by: ECO:0000269
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.69
fast: false
is: SBO:0000176
name: Galactoside 2-alpha-L-fucosyltransferase 1

metaR FAOXC4C4DCc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_e7d61c27_77f5_484c_b98d_85ee336af175
initial concentration: NaN
type: Species
has only substance units: false
name: SLC24A4
is encoded by: hsa:123041
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM dgchol e
has only substance units: false
boundary condition: false
is: HMDB00637
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
type: Species
initial amount: NaN
constant: false
name: glycochenodeoxycholate
is: CHEBI:36252

http://identifiers.org/biomodels.db/MODEL1310110004#_d117a795_e223_4efa_a09d_387f7543c997
initial concentration: NaN
has only substance units: false
is encoded by: hsa:U37519
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: _U37519_1_c

metaR FAOXC16OHC16r
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaM cspg c e
initial concentration: 1.0
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
type: Species
has only substance units: false
is: HMDB00630
is: CHEBI:16040
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan
constant: false

metaR FAS160COA
is described by: ECO:0000269
product: MODEL1310110004#
is: SBO:0000176
kinetic law: MODEL1310110004#
type: Reaction
name: fatty-acyl-CoA synthase (n-C16:0CoA)
reactant: MODEL1310110004#
fast: false
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.85
reversible: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD

metaM 2hb c
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
has only substance units: false
constant: false
boundary condition: false
name: 2-Hydroxybutyrate
initial amount: NaN
is: CHEBI:1148
is: HMDB00008
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_a1a92b8f_d6b8_43cc_9f37_d97da711614e
initial amount: NaN
name: _AI697028_1_m
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:AI697028
has only substance units: false

metaR BTNt4i
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
reversible: false
product: MODEL1310110004#
is: SBO:0000185
name: Biotin uptake (antiport)
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_65202c1d_72b5_473b_8b0f_23d8b2d0eea6
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _AI824319_1_r
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI824319
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_1a0e0093_7bba_4bd4_aafd_f1dc757400ac
is: SBO:0000252
is: Q9NS82
constant: false
initial concentration: NaN
name: SLC7A10
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:56301

metaR r0779
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
reactant: MODEL1310110004#
reversible: false
product: MODEL1310110004#
type: Reaction
fast: false
is described by: ECO:0000000
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_f4a9933b_1ffc_4c38_851b_89317d8d8330
is: Q9H5J4
name: ELOVL6
has only substance units: false
is encoded by: hsa:79071
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaR GTHPe
is version of: http://identifiers.org/ec-code/1.11.1.9
product: MODEL1310110004#
reactant: MODEL1310110004#
modifier: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: (2878.1) or (257202.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:3619451 NOTES:SAB
is: SBO:0000176
fast: false
type: Reaction
name: glutathione peroxidase (e)
kinetic law: MODEL1310110004#
is described by: ECO:0000269

metaR C40CPT1
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of butyrylcarnitine
type: Reaction

metaR SUCCOAPET
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR TRDRm
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
product: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
reversible: false
is: SBO:0000176
reactant: MODEL1310110004#
is described by: ECO:0000269
name: thioredoxin reductase (NADPH)
is version of: http://identifiers.org/ec-code/1.8.1.9
modifier: MODEL1310110004#
type: Reaction

metaR r1429
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110004#

metaR PHCHGSm
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
is: SBO:0000176
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
fast: false

metaM HC00319 c
boundary condition: false
initial amount: NaN
name: Malonate
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
type: Species
is: CHEBI:30794
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_f9f20816_d49b_4ae2_aaee_6516ae3176f2
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: _LOC728997_1_c
is encoded by: hsa:LOC728997
constant: false
has only substance units: false
type: Species
initial amount: NaN

metaR RE2973C
name: RE2973
is version of: http://identifiers.org/ec-code/2.7.11.1
type: Reaction
product: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.1.137
modifier: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.153
is described by: ECO:0000000
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
is: SBO:0000176

metaR r0578
is version of: http://identifiers.org/ec-code/4.1.2.27
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
product: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is: SBO:0000176
is described by: ECO:0000000

metaR GALt2 2
name: D-galactose transport via proton symport
product: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:
type: Reaction
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110004#
is: SBO:0000185
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#

metaM 3oddcoa m
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
boundary condition: false
name: 3-Oxododecanoyl-CoA
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:27868
is: HMDB03937
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_89b7cff6_ad5a_4d04_a579_80dc618a66cd
is: Q5JZF5
initial concentration: NaN
type: Species
initial amount: NaN
name: ALAS2
is: SBO:0000252
is encoded by: hsa:212
constant: false
boundary condition: true
has only substance units: false

metaR FAOXTC182TC162m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaR PE HSter
type: Reaction
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
fast: false
name: phosphatidylethanolamine scramblase
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#

metaR r1428
is described by: ECO:0000000
fast: false
type: Reaction
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is: SBO:0000185
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true

metaR HIBDm
fast: false
reversible: true
modifier: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.1.1.31
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
reactant: MODEL1310110004#
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial

metaR NADHtru
is: SBO:0000185
reversible: false
name: NADH transporter, endoplasmic reticulum
fast: false
is described by: ECO:0000000
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110004#
type: Reaction
product: MODEL1310110004#

metaM nm2masn g
is: C05884
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C42H70N3O30X CHARGE: 0
boundary condition: false
constant: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: SBO:0000247

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

metaR biomass reaction
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185
fast: false
reversible: false
name: Generic human biomass reaction

metaR r0365
type: Reaction
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
is: SBO:0000176
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
reversible: false
is version of: http://identifiers.org/ec-code/1.3.1.72
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
modifier: MODEL1310110004#
fast: false
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_2e2607fb_ce7e_4e70_a410_df3534eccb4a
boundary condition: true
is encoded by: hsa:5831
has only substance units: false
is: SBO:0000252
name: PYCR1
initial concentration: NaN
is: A6NFM2
initial amount: NaN
type: Species
constant: false

metaR EX ptdca LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentadecanoate exchange
type: Reaction

metaR GPIDAer
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
kinetic law: MODEL1310110004#
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110004#

metaM lnlc r
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30245
constant: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
is: HMDB00673
initial amount: NaN
name: linoleate
has only substance units: false

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaR ECOAH12m
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reversible: true
type: Reaction
reactant: MODEL1310110004#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000304

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

metaR EX c81crn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for octenoyl carnitine
type: Reaction

metaR r0579
reversible: true
reactant: MODEL1310110004#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.13.11.19
type: Reaction
kinetic law: MODEL1310110004#
is: SBO:0000176
fast: false
modifier: MODEL1310110004#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_f3107f21_c0b2_4c9e_aaa8_8a4222ffe745
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:493
constant: false
is: P23634
name: ATP2B4
has only substance units: false
boundary condition: true

metaR 5ADTSTSTERONESte
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110004#
is described by: ECO:0000000
reversible: true
name: sulfonated testosterone transport

metaM mlthf c
boundary condition: false
initial concentration: 1.0
constant: false
name: 5,10-Methylenetetrahydrofolate
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: C00143
is: SBO:0000247
is: HMDB01533
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:15636

http://identifiers.org/biomodels.db/MODEL1310110004#_cecfc8e9_7e05_40ba_961f_5b1c5ee6af12
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:6582
is: SBO:0000252
has only substance units: false
boundary condition: true
is: O15244
name: SLC22A2

metaM thymd m
is: SBO:0000247
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
name: Thymidine
initial concentration: 1.0
is: CHEBI:17748
is: HMDB00273
constant: false
initial amount: NaN
type: Species
is: C00214
boundary condition: false
has only substance units: false

metaM CE4790 m
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
is: CHEBI:57923
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
type: Species
initial amount: NaN

metaM hexe3coa x
is: HMDB06522
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
name: 3-hexenoylcoa
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM ksi deg17 l
is: SBO:0000247
has only substance units: false
is: CHEBI:12936
name: keratan sulfate I, degradation product 17
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00143
type: Species
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
initial concentration: 1.0

metaM cdp m
type: Species
has only substance units: false
is: CHEBI:58069
is: HMDB01546
initial amount: NaN
is: SBO:0000247
constant: false
name: CDP(3-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaM idour l
is: CHEBI:21338
name: L-iduronate
initial concentration: 1.0
is: HMDB02704
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial amount: NaN
constant: false
has only substance units: false

metaM ksii core2 deg3 l
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
constant: false
type: Species
name: keratan sulfate II (core 2-linked), degradation product 3
is: HMDB00143
is: SBO:0000247
is: CHEBI:12936
boundary condition: false

metaM sphs1p c
type: Species
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: HMDB00277
boundary condition: false
initial amount: NaN

metaR MI34PP
notes: GENE_ASSOCIATION: (3631.2) or (3631.1) or (8821.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:7608176,PMID:9295334 NOTES:NCD
modifier: MODEL1310110004#
name: inositol-3,4-bisphosphate 4-phosphatase
product: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.66
reversible: false
is: SBO:0000176
reactant: MODEL1310110004#

metaM ksi pre3 g
name: keratan sulfate I biosynthesis, precursor 3
constant: false
type: Species
initial concentration: 1.0
is: C00130
notes: FORMULA: C93H152N6O67X CHARGE: -1
is: SBO:0000247
is: HMDB00175
initial amount: NaN
boundary condition: false
is: CHEBI:58053
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_a9cd667b_a2fe_4936_8a50_9963d9916d8d
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ATP5E
constant: false
is encoded by: hsa:514
is: P56381
has only substance units: false
type: Species
initial concentration: NaN

metaM itp e
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:57614
is: SBO:0000247
constant: false
is: HMDB00189
has only substance units: false
name: ITP(3-)
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaR r0355
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
modifier: MODEL1310110004#
reversible: false
is version of: http://identifiers.org/ec-code/4.2.1.3
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
reactant: MODEL1310110004#

metaR FAOXC142C142OHm
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C14:2OH)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_1fe4ae9e_7a89_4fc4_bf38_ff46baa25067
is encoded by: hsa:205
name: AK4
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

metaR ALAR
reversible: true
product: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000212
type: Reaction
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110004#
is: SBO:0000176
name: alanine racemase

metaR CLPNDt
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
name: fatty acid transport via diffusion
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110004#
is: SBO:0000185

metaR G13MT U
is: SBO:0000176
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.132
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
product: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000000
reversible: false

metaM dgdp n
is: SBO:0000247
is: HMDB00960
constant: false
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
name: dGDP(2-)
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58595

http://identifiers.org/biomodels.db/MODEL1310110004#_fd3ccdb8_b245_4628_bb72_a943f3600f89
initial amount: NaN
is encoded by: hsa:60490
constant: false
is: Q96CD2
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: PPCDC
boundary condition: true

metaR CYANt
reactant: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
name: Cyanide transport via diffusion (extracellular to cytosol)
is described by: ECO:0000000
type: Reaction
product: MODEL1310110004#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM

metaM tdec4ecoa m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: HMDB00792
name: trans4decenoylcoa
has only substance units: false
is: C08277
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM ksi deg14 l
boundary condition: false
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
initial concentration: 1.0
is: CHEBI:12936
name: keratan sulfate I, degradation product 14
constant: false
is: HMDB00143
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247

metaM 3oddcoa x
name: 3-Oxododecanoyl-CoA
type: Species
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
is: SBO:0000247
is: HMDB03937
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27868
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_0c47e9ea_8914_4528_b71c_c074bf3de377
is: H7C5B8
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4708
has only substance units: false
name: NDUFB2
type: Species

metaM cdp n
is: HMDB01546
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:58069
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaR HS3ly
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is described by: ECO:0000000
name: heparan-N-sulfatase, lysosomal
reversible: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
product: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/3.10.1.1

http://identifiers.org/biomodels.db/MODEL1310110004#_5b42012e_05bc_49a5_8515_09d30cb5ecaa
initial amount: NaN
is: SBO:0000252
type: Species
is: P49247
name: RPIA
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:22934
constant: false

metaM strdnccoa c
initial amount: NaN
is: SBO:0000247
is: C16163
name: stearidonyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205473
boundary condition: false
has only substance units: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
type: Species
initial concentration: 1.0
is: HMDB06519
constant: false

metaM 5dpmev x
type: Species
initial concentration: 1.0
is: HMDB01090
has only substance units: false
is: CHEBI:15899
constant: false
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
is: SBO:0000247
initial amount: NaN
name: (R)-5-Diphosphomevalonate
boundary condition: false

metaR r0354
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110004#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
product: MODEL1310110004#
is described by: ECO:0000000
reactant: MODEL1310110004#
reversible: false

metaM docohexcoa x
boundary condition: false
type: Species
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/24892790
name: 2,4,7,10,13,16-docosahexenoylcoa
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C43H62N7O17P3S CHARGE: -4
initial amount: NaN

metaR TYRt
type: Reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000269
reversible: true
product: MODEL1310110004#
name: L-tyrosine transport
fast: false
is: SBO:0000185
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
modifier: MODEL1310110004#

metaR SACCD4m
is version of: http://identifiers.org/ec-code/1.5.1.8
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.10 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
reversible: false
product: MODEL1310110004#
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000176
name: saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110004#
type: Reaction

metaR r1649
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110004#
reversible: true
is described by: ECO:0000000
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110004#
fast: false
modifier: MODEL1310110004#

metaM sphs1p e
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: HMDB00277
boundary condition: false
initial amount: NaN
is: CHEBI:60119
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
name: sphingosine 1-phosphate(1-)
has only substance units: false

metaM dgdp m
type: Species
constant: false
is: CHEBI:58595
name: dGDP(2-)
boundary condition: false
is: HMDB00960
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaM f6p c
is: C00085
is: CHEBI:57579
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00124
type: Species
name: D-Fructose 6-phosphate
initial concentration: 1.0
constant: false
is: http://identifiers.org/pubchem.compound/3385
is: SBO:0000247

metaM 3tdcrn e
type: Species
boundary condition: false
name: 3-hydroxy-tetradecanoyl carnitine
has only substance units: false
initial amount: NaN
notes: FORMULA: C21H41NO5 CHARGE: 0
is: SBO:0000247
is: HMDB13336
initial concentration: 1.0
constant: false

metaR C4tcx
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine from peroxisomes
type: Reaction

metaM accoa x
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
initial concentration: 1.0
is: C00024
initial amount: NaN
is: HMDB01206
is: SBO:0000247
is: CHEBI:57288
type: Species
name: Acetyl-CoA
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_c49c57d7_0015_4f08_86d4_447d9fab6512
name: PLCZ1
initial concentration: NaN
is encoded by: hsa:89869
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
is: Q86YW0
is: SBO:0000252

metaM aacoa c
name: Acetoacetyl-CoA
is: SBO:0000247
initial amount: NaN
is: CHEBI:57286
has only substance units: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01484
is: C00332

http://identifiers.org/biomodels.db/MODEL1310110004#_e49872ec_7bd7_4475_abc6_079af0703304
name: AMY1A
boundary condition: true
is: SBO:0000252
is: Q6NSB3
is encoded by: hsa:276
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false

metaM HC02206 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:57399
is: SBO:0000247
boundary condition: false
name: prostaglandin C1(1-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_fcb2ccdb_ddb0_4ce7_88cf_8748057cd712
has only substance units: false
is: O00483
name: NDUFA4
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4697
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_175760b0_b901_4aa5_a566_72e93cdafe7e
is encoded by: hsa:115019
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
constant: false
name: SLC26A9
is: B3KXK1
has only substance units: false

metaR GCALDD
is: SBO:0000176
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.36
product: MODEL1310110004#
fast: false
reversible: false
kinetic law: MODEL1310110004#
name: Glycolaldehyde dehydrogenase
modifier: MODEL1310110004#
is described by: ECO:0000304

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaM ivcoa c
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
name: Isovaleryl-CoA
is: HMDB01113

metaM sebacid x
is: SBO:0000247
is: C08277
initial concentration: 1.0
is: HMDB00792
boundary condition: false
has only substance units: false
name: sebacicacid
initial amount: NaN
constant: false
notes: FORMULA: C10H16O4 CHARGE: -2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_8613cfd1_8598_4339_9672_1e700093c59f
constant: false
has only substance units: false
is encoded by: hsa:85365
type: Species
initial concentration: NaN
initial amount: NaN
name: ALG2
is: SBO:0000252
is: Q9H553
boundary condition: true

metaR r1713
modifier: MODEL1310110004#
name: Y+LAT2 Utilized transport
product: MODEL1310110004#
reactant: MODEL1310110004#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_f0d03c6c_c89c_4871_a488_c46a12291753
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
name: _AL525798_1_c
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AL525798

metaR r0994
kinetic law: MODEL1310110004#
reversible: true
reactant: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
product: MODEL1310110004#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Facilitated diffusion

http://identifiers.org/biomodels.db/MODEL1310110004#_eba54d55_06be_4894_b6df_59699f7acd92
name: _AI348006_1_c
is encoded by: hsa:AI348006
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false

metaM 4izp c
constant: false
is: CHEBI:57255
is: SBO:0000247
name: 4-Imidazolone-5-propanoate
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB01014
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
boundary condition: false

metaR PYRt2p
fast: false
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD
product: MODEL1310110004#
name: pyruvate peroxisomal transport via proton symport
is described by: ECO:0000269
reactant: MODEL1310110004#
type: Reaction

metaR TSTSTERONEt
fast: false
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
reactant: MODEL1310110004#
is: SBO:0000185
name: Testosterone transport
type: Reaction
reversible: true
is described by: ECO:0000269
product: MODEL1310110004#

metaR CYTK12n
is: SBO:0000176
name: cytidylate kinase (dCMP,dCTP),nuclear
reversible: true
kinetic law: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
reactant: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
modifier: MODEL1310110004#

metaM 3tdcrn c
has only substance units: false
is: HMDB02014
constant: false
notes: FORMULA: C21H41NO5 CHARGE: 0
name: 3-hydroxy-tetradecanoyl carnitine
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR r1647
modifier: MODEL1310110004#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110004#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110004#
fast: false

metaR DGTPtn
reversible: true
reactant: MODEL1310110004#
fast: false
is: SBO:0000185
name: dGTP diffusion in nucleus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
kinetic law: MODEL1310110004#
product: MODEL1310110004#
type: Reaction

metaM HC02206 e
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
constant: false
has only substance units: false
is: CHEBI:57399
initial concentration: 1.0
type: Species
name: prostaglandin C1(1-)
is: SBO:0000247
initial amount: NaN

metaM alpro m
is: CHEBI:16882
name: S-Aminomethyldihydrolipoylprotein
boundary condition: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: CH6NS2X CHARGE: 1 EHMN_ABBREVIATION: C01242

metaR GLCAASE1ly
name: beta-glucuronidase, lysosomal
type: Reaction
reversible: false
reactant: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
kinetic law: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.31

http://identifiers.org/biomodels.db/MODEL1310110004#_c1c4c72c_dc9b_4c01_8e18_aa3158618a5e
constant: false
has only substance units: false
is: Q9Y633
initial amount: NaN
is encoded by: hsa:5136
boundary condition: true
initial concentration: NaN
name: PDE1A
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_b7daac76_ce52_43b1_a4bd_51c8ea580d9a
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10201
type: Species
has only substance units: false
is: SBO:0000252
is: O75414
constant: false
initial amount: NaN
name: NME6

metaM pail45p hs n
boundary condition: false
is: CHEBI:28910
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR r1648
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_08f63323_57c6_417f_9c82_860f3393ca8d
type: Species
is encoded by: hsa:2739
constant: false
is: Q04760
initial concentration: NaN
has only substance units: false
name: GLO1
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR 13DAMPPOX
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.4.3.21
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
type: Reaction
product: MODEL1310110004#
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.4.3.22
is: SBO:0000176
fast: false
kinetic law: MODEL1310110004#
reversible: false

metaR PYRt2r
reactant: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
is: SBO:0000185
kinetic law: MODEL1310110004#
reversible: true
name: pyruvate reversible transport via proton symport
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
product: MODEL1310110004#

metaM hexdiac r
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C16H28O4 CHARGE: -2
is: C08260
name: hexadecanediocacid
is: HMDB00672
initial amount: NaN
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_f6c61b05_2855_47c0_adb6_b4984ecdcb58
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is: B7Z4Y6
name: ALPL
type: Species
has only substance units: false
is encoded by: hsa:249
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_7df2f6c5_6dbd_43da_8a07_9ac756946fbe
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_metaR_FUCFUCFUCGALACGLC13GALACGLCGAL14ACGLCGALGLUSIDEtg
reversible: true
kinetic law: MODEL1310110004#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
product: MODEL1310110004#
name: blood group intracellular transport
reactant: MODEL1310110004#
type: Reaction
fast: false

metaR r0580
kinetic law: MODEL1310110004#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.99.7
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
reversible: true
product: MODEL1310110004#

metaR XYLt
name: D-xylose reversible transport
is: SBO:0000185
reversible: true
product: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
type: Reaction
reactant: MODEL1310110004#
modifier: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_c979a40e_9fbd_4c8f_82f7_09a3b3e44cbd
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:160851
is: Q86XP1
name: DGKH
constant: false
initial concentration: NaN
is: SBO:0000252

metaR EX c51crn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

metaR CO2t
product: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
fast: false
kinetic law: MODEL1310110004#
type: Reaction
name: CO2 transporter via diffusion
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_1373bb61_70d7_4d53_93a6_c317889d8c48
is encoded by: hsa:114805
type: Species
initial concentration: NaN
is: Q8IUC8
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: GALNT13

metaR FPGS3m
is: SBO:0000176
modifier: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (2356.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.2.17 Confidence Level: 4 AUTHORS: PMID:10777604 NOTES:IT
fast: false
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.3.2.17
name: folylpolyglutamate synthetase, mitochondrial
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_387f8a0e_5f21_4824_9e05_a59abb3550ac
is encoded by: hsa:4711
has only substance units: false
name: NDUFB5
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: O43674
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_299fd976_8cbe_49b3_9bfb_8841055d4a52
is: SBO:0000252
type: Species
name: ACAT2
is encoded by: hsa:39
has only substance units: false
is: Q9BWD1
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN

metaM citr L m
is: HMDB00904
name: L-citrulline
boundary condition: false
is: CHEBI:16349
type: Species
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
initial amount: NaN

metaR r1645
reversible: true
reactant: MODEL1310110004#
product: MODEL1310110004#
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110004#

metaR r0999
type: Reaction
name: Facilitated diffusion
kinetic law: MODEL1310110004#
is described by: ECO:0000000
reactant: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110004#
reversible: true
is: SBO:0000185

metaR FAOXC164GC163m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaM itp c
is: SBO:0000247
has only substance units: false
is: CHEBI:57614
initial concentration: 1.0
boundary condition: false
type: Species
name: ITP(3-)
initial amount: NaN
constant: false
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081

http://identifiers.org/biomodels.db/MODEL1310110004#_6885169c_7e24_44b7_a091_e5a9f1c0b9ed
name: SPTLC1:SPTLC2
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:9517
is encoded by: hsa:10558
is: SBO:0000297
has only substance units: false
initial concentration: NaN
has part: O15270
has part: O15269
constant: false

metaR r1935
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110004#
reversible: false
is described by: ECO:0000000
product: MODEL1310110004#

metaR SERGLYexR
reversible: true
product: MODEL1310110004#
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000304
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
name: L-Serine/Glycine reversible exchange
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_65269f62_ae92_4ecd_9945_ad63a8127b87
type: Species
is encoded by: hsa:2517
has only substance units: false
boundary condition: true
is: P04066
name: FUCA1
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM c5dc c
type: Species
initial concentration: 1.0
name: glutaryl carnitine
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB13130
notes: FORMULA: C12H21NO6 CHARGE: 0
boundary condition: false
constant: false

metaM ha pre1 l
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16126
name: hyaluronan biosynthesis, precursor 1

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

metaR r1646
product: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110004#
is described by: ECO:0000000
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110004#_metaR_EX_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1 exchange
type: Reaction

metaR r1862
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
reversible: false
modifier: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
name: Y+LAT2 Utilized transport

metaM pail45p hs m
initial amount: NaN
type: Species
boundary condition: false
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial concentration: 1.0

metaR r2341
is described by: ECO:0000000
kinetic law: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110004#
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction
is: SBO:0000185
reversible: true

metaR r0998
type: Reaction
is: SBO:0000185
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reversible: true
product: MODEL1310110004#
reactant: MODEL1310110004#
fast: false

metaR r0149
reversible: true
modifier: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
product: MODEL1310110004#
type: Reaction
is: SBO:0000176
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.14.13.39
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_be382c64_fa2f_481d_9930_de9170cedaa1
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:79053
initial concentration: NaN
name: ALG8
constant: false

metaR r1863
reversible: false
reactant: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000185

metaR DSAT
reactant: MODEL1310110004#
name: dihydrosphingosine N-acyltransferase
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
product: MODEL1310110004#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110004#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_18f6ea4c_8980_4b82_8d59_a05aa2e1b1d0
constant: false
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:8659
has only substance units: false
name: ALDH4A1
initial concentration: NaN
is: SBO:0000252

metaR r1643
reactant: MODEL1310110004#
modifier: MODEL1310110004#
product: MODEL1310110004#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaM dadp c
type: Species
is: HMDB01508
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:57667
has only substance units: false
name: dADP
initial concentration: 1.0
is: C00206
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
boundary condition: false

metaM octe5coa m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
name: 5-octenoylcoa
is: SBO:0000247
boundary condition: false
type: Species
constant: false
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0

metaR r2506
is: SBO:0000185
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
type: Reaction
reactant: MODEL1310110004#
fast: false
reversible: true
is described by: ECO:0000000
name: Utilized transport
product: MODEL1310110004#

metaM s2l2fn2m2masn e
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: C00255
initial amount: NaN
name: PA6
is: HMDB00244
is: CHEBI:3554
type: Species
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: SBO:0000247
constant: false

metaM dump n
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01409
initial amount: NaN
boundary condition: false
is: CHEBI:246422
name: dUMP(2-)
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365

metaR PIPLC
reversible: false
product: MODEL1310110004#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.4.11
type: Reaction
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
name: phosphatidylinositol phospholipase C
modifier: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD

metaM cdp e
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial concentration: 1.0
is: HMDB01546
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:58069
constant: false
name: CDP(3-)
initial amount: NaN

metaM itp n
name: ITP(3-)
is: HMDB00189
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:57614
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
boundary condition: false

metaR THMPPtm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:12014993 NOTES:IT
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110004#
name: Thiamine diphosphate transport in via anion antiport, mitochondria
reactant: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
reversible: false

metaM ksi pre15 g
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
is: CHEBI:58053
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00175
boundary condition: false
is: C00130
is: SBO:0000247
constant: false
name: keratan sulfate I biosynthesis, precursor 15
initial amount: NaN

metaM idour e
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
is: SBO:0000247
is: CHEBI:21338
name: L-iduronate
type: Species
is: HMDB02704
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_e8ac2bb0_ed64_4ca0_8dbd_98180c83c1a5
is: SBO:0000252
type: Species
name: PIGT
constant: false
is: Q969N2
is encoded by: hsa:51604
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM xol27oh m
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
is: HMDB02103
is: SBO:0000247
type: Species
name: 26-hydroxycholesterol
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: CHEBI:17703

metaR EX ksi deg1 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I, degradation product 1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_adf2baf3_1075_4a14_8660_2c6056fe3492
is: Q9BY07
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:57835
initial concentration: NaN
constant: false
type: Species
has only substance units: false
name: SLC4A5

http://identifiers.org/biomodels.db/MODEL1310110004#_9410deaa_52c2_42d4_9237_3d235e534e7f
is: SBO:0000252
is: Q9NY28
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
name: GALNT8
is encoded by: hsa:26290
initial concentration: NaN
type: Species

metaR r2343
kinetic law: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
type: Reaction
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110004#
is: SBO:0000185

metaR r1644
is: SBO:0000185
fast: false
product: MODEL1310110004#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110004#

metaR UDPGLCter
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
is described by: ECO:0000000
kinetic law: MODEL1310110004#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
is: SBO:0000185
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_ed22400c_ddef_451e_b58b_65790108a567
boundary condition: true
is encoded by: hsa:516
is: Q6FIH7
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ATP5G1
initial concentration: NaN
constant: false

metaR r2507
type: Reaction
name: Utilized transport
product: MODEL1310110004#
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110004#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_83cac35c_5297_4949_8149_46e7caa780c1
is: Q9HBH5
constant: false
name: RDH14
boundary condition: true
is encoded by: hsa:57665
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaM lnlc c
boundary condition: false
initial concentration: 1.0
is: HMDB00673
type: Species
is: CHEBI:30245
has only substance units: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: SBO:0000247
constant: false
initial amount: NaN
name: linoleate

http://identifiers.org/biomodels.db/MODEL1310110004#_d83d39ea_b278_4473_b688_16b7910d743b
name: NDUFS8
is encoded by: hsa:4728
initial concentration: NaN
type: Species
is: O00217
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110004#_0ee3523f_85d0_445b_868c_6150519eeb5a
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:57786
is: Q9NYW8
initial amount: NaN
has only substance units: false
name: RBAK
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_a680fa5a_66c8_4542_b379_e942aaf312c7
type: Species
constant: false
initial amount: NaN
has only substance units: false
name: _BG035985_1_c
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:BG035985

metaR ACHEe
type: Reaction
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
kinetic law: MODEL1310110004#
name: Acetylcholinesterase
reactant: MODEL1310110004#
fast: false
reversible: false
modifier: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.7
is described by: ECO:0000269

metaR RE3001M
is version of: http://identifiers.org/ec-code/1.3.1.34
product: MODEL1310110004#
is described by: ECO:0000000
name: RE3001
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
reactant: MODEL1310110004#
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false

metaR MMEm
modifier: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
name: methylmalonyl-CoA epimerase/racemase
is version of: http://identifiers.org/ec-code/5.1.99.1
product: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110004#_9d9384d5_ff82_4c54_9554_cee0b7001f14
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:9197
constant: false
name: SLC33A1
is: O00400
initial concentration: NaN

metaR DOLDPP Uer
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.6.1.43
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
product: MODEL1310110004#
modifier: MODEL1310110004#
reactant: MODEL1310110004#
reversible: false
kinetic law: MODEL1310110004#
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)

http://identifiers.org/biomodels.db/MODEL1310110004#_cd1da455_00b6_4f3c_98be_be5608612461
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: P48448
name: ALDH3B2
is encoded by: hsa:222

metaR VALt5m
is: SBO:0000185
kinetic law: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
reactant: MODEL1310110004#
name: Valine reversible mitochondrial transport
reversible: true

metaR r1641
modifier: MODEL1310110004#
fast: false
product: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#

metaR r2344
is described by: ECO:0000000
reactant: MODEL1310110004#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
fast: false
reversible: true
type: Reaction
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_23e5ba7e_4d77_46fa_8397_bbe281bfca52
name: ACAT2
boundary condition: true
is encoded by: hsa:39
is: SBO:0000252
type: Species
has only substance units: false
is: Q9BWD1
constant: false
initial amount: NaN
initial concentration: NaN

metaM mi134p c
type: Species
is: SBO:0000247
is: CHEBI:58414
boundary condition: false
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
is: HMDB01143
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0

metaR RE0452M
reactant: MODEL1310110004#
is described by: ECO:0000000
reversible: true
product: MODEL1310110004#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110004#
name: RE0452
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
type: Reaction

metaM cdp c
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
type: Species
is: HMDB01546
is: SBO:0000247
boundary condition: false
is: CHEBI:58069
name: CDP
is: C00112
constant: false

metaM saccrp L m
constant: false
name: L-saccharopinate(1-)
is: CHEBI:57951
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00279
notes: FORMULA: C11H19N2O6 CHARGE: -1 INCHI: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)/p-1/t7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00363
has only substance units: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_7c855070_2eb2_464b_b6e5_5785253a6cb1
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
name: HPGDS
is encoded by: hsa:27306
is: O60760
constant: false
is: SBO:0000252
initial amount: NaN

metaR FTHFL
name: Formate-tetrahydrofolate ligase
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.5.1.5
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#
fast: false
is described by: ECO:0000134
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (4522.1) or (286297.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110004#_3a44c4d6_fb4f_43f9_ac62_373a41b700f1
name: NME1
has only substance units: false
is: P15531
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:4830
is: SBO:0000252
boundary condition: true
constant: false

metaR r1642
fast: false
product: MODEL1310110004#
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110004#

metaM ksii core4 pre8 g
name: keratan sulfate II biosynthesis, precursor 8
is: CHEBI:58053
is: HMDB00175
notes: FORMULA: C83H134N7O61SX CHARGE: -2
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C00130
boundary condition: false
initial amount: NaN
constant: false
type: Species

metaM ksi pre6 g
constant: false
name: keratan sulfate I biosynthesis, precursor 6
is: SBO:0000247
is: CHEBI:58053
is: C00130
initial amount: NaN
boundary condition: false
is: HMDB00175
notes: FORMULA: C107H174N7O80SX CHARGE: -2
type: Species
has only substance units: false
initial concentration: 1.0

metaM dd5ecoa m
is: HMDB13028
type: Species
is: C01942
name: 5-dodecenoylcoa
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false

metaR GALASE4ly
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110004#
name: beta-galactosidase, lysosomal
product: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
is: SBO:0000176
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_2fb63629_0da4_458a_ae07_fe2c6fc3260c
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:55350
has only substance units: false
name: VNN3
constant: false
type: Species
initial amount: NaN
boundary condition: true

metaM dgcholcoa x
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24?,25-,26+,27?,28?,29?,30+,31+,34?,36+,37+,38?,42+,44-,45+/m0/s1 EHMN_ABBREVIATION: C05461
is: SBO:0000247
constant: false
is: HMDB06897
name: Chenodeoxyglycocholoyl-CoA
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C05461
type: Species

metaR EX 3ddcrn
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaM lnlc e
name: linoleate
boundary condition: false
is: HMDB00673
initial concentration: 1.0
type: Species
is: CHEBI:30245
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-

metaM nadp r
is: SBO:0000247
boundary condition: false
type: Species
constant: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate
is: CHEBI:58349
is: C00006
initial amount: NaN
initial concentration: 1.0
is: HMDB00217

http://identifiers.org/biomodels.db/MODEL1310110004#_35ff5f01_25f6_4656_aad4_ead3ccaa4fa9
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:NM 001929
name: _NM_001929_1_c
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110004#_e6106084_6e2b_476e_bffa_029a1bea66c5
name: AK2
type: Species
constant: false
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:204
initial amount: NaN
initial concentration: NaN

metaR C12OHc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

metaM accoa n
has only substance units: false
constant: false
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
name: acetyl-CoA(4-)
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:57288
initial amount: NaN

metaR r0464
reversible: true
fast: false
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000000
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
kinetic law: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
is: SBO:0000176

metaR r2346
reactant: MODEL1310110004#
product: MODEL1310110004#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction

metaM xol27oh r
initial amount: NaN
is: SBO:0000247
is: CHEBI:17703
has only substance units: false
boundary condition: false
constant: false
is: HMDB02103
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
initial concentration: 1.0
type: Species
name: 26-hydroxycholesterol

metaR G14T7g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
modifier: MODEL1310110004#
product: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_676eabe3_f12a_4c70_a344_a842f64986d1
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: _AL038231_1_c
is encoded by: hsa:AL038231
initial amount: NaN
has only substance units: false

metaM aacoa m
constant: false
type: Species
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: HMDB01484
boundary condition: false
has only substance units: false
name: acetoacetyl-CoA(4-)
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57286

metaM damp c
name: dAMP(2-)
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
is: CHEBI:58245
is: HMDB00905
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_109fea2c_078c_4776_abc6_229608e91099
boundary condition: true
constant: false
initial amount: NaN
name: SLC17A5
is: SBO:0000252
type: Species
has only substance units: false
is: Q9NRA2
is encoded by: hsa:26503
initial concentration: NaN

metaR UDPGALtg
kinetic law: MODEL1310110004#
is: SBO:0000185
type: Reaction
reversible: true
modifier: MODEL1310110004#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
fast: false
name: UDP-Gal Golgi transport via CMP antiport
reactant: MODEL1310110004#
product: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_a88f9a8b_0257_46bd_b80f_a87e2072fab3
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: TXNRD1
is: SBO:0000252
type: Species
is encoded by: hsa:7296

http://identifiers.org/biomodels.db/MODEL1310110004#_9c415b4b_c7df_43f4_9399_ee7f8034c54c
is: Q8N3T1
initial concentration: NaN
is encoded by: hsa:117248
type: Species
name: GALNTL2
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR r1640
is: SBO:0000185
modifier: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110004#
fast: false
product: MODEL1310110004#

metaM icit c
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: CHEBI:16087
constant: false
type: Species
initial concentration: 1.0
name: Isocitrate
is: HMDB00193
is: C00311
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR r2347
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110004#
product: MODEL1310110004#
fast: false
type: Reaction
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110004#

metaR r0463
type: Reaction
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
product: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
reversible: true
kinetic law: MODEL1310110004#
fast: false
is described by: ECO:0000000

metaM gua e
initial amount: NaN
type: Species
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial concentration: 1.0
is: CHEBI:16235
is: HMDB00132
is: SBO:0000247
has only substance units: false
constant: false
name: guanine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_600e7f53_1db5_4df6_9176_69eeea435a3a
constant: false
is: Q99685
name: MGLL
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:11343
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR BAAT3x
product: MODEL1310110004#
name: bile acid Coenzyme A: amino acid N-acyltransferase
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: false
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:third version analog added as per KEGG NJ
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_ed767327_3686_44f7_ac9e_4957f219f144
boundary condition: true
is encoded by: hsa:10400
initial amount: NaN
has only substance units: false
name: PEMT
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_5b85e408_2ce3_474e_a6c6_0c0e53e0cda6
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AGPAT7
has only substance units: false
initial amount: NaN
boundary condition: true
name: _AGPAT7_1_c
constant: false

metaM s2l2n2m2m l
notes: FORMULA: C84H136N6O62 CHARGE: -2
initial amount: NaN
is: HMDB00573
type: Species
is: CHEBI:30825
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
name: de-Fuc form of PA6 (w/o peptide linkage)
is: SBO:0000247

metaR GALASE12ly
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
fast: false
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
reversible: false
product: MODEL1310110004#

metaM acac m
initial concentration: 1.0
is: CHEBI:13705
boundary condition: false
is: HMDB00060
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
name: acetoacetate
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
type: Species

metaM 3ttetddcoacrn e
boundary condition: false
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
is: SBO:0000247
constant: false
is: HMDB02014
notes: FORMULA: C21H37NO5 CHARGE: 0
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR LPS2e
fast: false
is: SBO:0000176
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.1.3
reactant: MODEL1310110004#
name: lipase, extracellular
type: Reaction
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
modifier: MODEL1310110004#
reversible: false
is described by: ECO:0000000

metaR DOLPMT1 Uer
modifier: MODEL1310110004#
fast: false
type: Reaction
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is described by: ECO:0000000
reactant: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.258
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110004#
reversible: false
is: SBO:0000176

metaM ha pre1 e
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16126
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
has only substance units: false
name: hyaluronan biosynthesis, precursor 1
boundary condition: false

metaM xyl D l
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15936
is: SBO:0000247
boundary condition: false
type: Species
constant: false
name: aldehydo-D-xylose

http://identifiers.org/biomodels.db/MODEL1310110004#_4d0e5341_d742_4186_85e0_7363a8e5ef4e
constant: false
name: CANT1
initial amount: NaN
is encoded by: hsa:124583
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: Q8WVQ1

metaR 34HPPte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
name: Transport of 3-(4-hydroxyphenyl)pyruvate
kinetic law: MODEL1310110004#
fast: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110004#
product: MODEL1310110004#

metaM nadp m
initial amount: NaN
is: C00006
name: Nicotinamide adenine dinucleotide phosphate
is: HMDB00217
is: CHEBI:58349
has only substance units: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false

metaR PYRt2m
name: pyruvate mitochondrial transport via proton symport
type: Reaction
product: MODEL1310110004#
modifier: MODEL1310110004#
reactant: MODEL1310110004#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD

http://identifiers.org/biomodels.db/MODEL1310110004#_c693f80b_3750_4fcd_bb20_7fe8334f1572
boundary condition: true
is: Q96CD2
initial concentration: NaN
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: PPCDC
is encoded by: hsa:60490

metaR r2508
name: Utilized transport
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000185

metaM pail45p hs c
name: phosphatidylinositol 4,5-bisphosphate
initial concentration: 1.0
is: CHEBI:28910
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaM accoa m
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB01206
type: Species
name: Acetyl-CoA
is: C00024
initial amount: NaN
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
is: CHEBI:57288

metaR GALASE6ly
is version of: http://identifiers.org/ec-code/3.2.1.18
modifier: MODEL1310110004#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110004#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110004#_f79883ec_ee91_47fb_a99b_58dab7a88a55
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:100128062
type: Species
name: _100128062_1_m

http://identifiers.org/biomodels.db/MODEL1310110004#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaR M1316Mg
fast: false
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.114
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
modifier: MODEL1310110004#
product: MODEL1310110004#
is described by: ECO:0000000
reversible: false

metaR MI134PP
fast: false
name: inositol-1,3,4-trisphosphate 1-phosphatase
reversible: false
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.57
is: SBO:0000176
modifier: MODEL1310110004#
is described by: ECO:0000269
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_dce3a959_2349_4ac8_8a81_380e4ef93063
name: SLC6A8
constant: false
has only substance units: false
initial concentration: NaN
is: B4DIA3
is: SBO:0000252
is encoded by: hsa:6535
boundary condition: true
initial amount: NaN
type: Species

metaR GULLACter
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110004#
name: gulonolactone endoplasmic reticular transport
kinetic law: MODEL1310110004#
is: SBO:0000185
reversible: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD

metaM gua c
initial amount: NaN
type: Species
initial concentration: 1.0
is: C00242
has only substance units: false
is: CHEBI:16235
is: HMDB00132
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
name: Guanine

metaR r0990
fast: false
name: Postulated transport reaction
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
product: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

metaM dump m
is: CHEBI:246422
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
name: dUMP(2-)
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
type: Species
is: HMDB01409
initial amount: NaN

metaM 3decdicoa x
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 3,7-decadienoylcoa
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966

metaR r2509
type: Reaction
fast: false
reactant: MODEL1310110004#
is: SBO:0000185
name: Utilized transport
product: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reversible: true

metaM 3ttetddcoacrn c
is: SBO:0000247
constant: false
is: HMDB02014
type: Species
has only substance units: false
notes: FORMULA: C21H37NO5 CHARGE: 0
initial concentration: 1.0
boundary condition: false
name: 3-hydroxy trans5,8tetradecadienoyl carnitine
initial amount: NaN

metaR THMMPtm
product: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12014993,PMID:9755848 NOTES:IT
reactant: MODEL1310110004#
fast: false
is described by: ECO:0000000
name: Thiamine monophosphate transport, mitochondrial

metaM HC01223 m
constant: false
is: CHEBI:57340
type: Species
has only substance units: false
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
boundary condition: false
initial concentration: 1.0

metaM HC00591 m
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
name: 2-oxoglutaramate
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
initial concentration: 1.0
type: Species
is: CHEBI:16769

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM idour c
has only substance units: false
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial amount: NaN
is: HMDB02704
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:21338
initial concentration: 1.0
name: L-iduronate

metaR S6T7g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
kinetic law: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110004#

metaM udp e
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
name: UDP(3-)
boundary condition: false
is: CHEBI:58223
is: HMDB00295
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_42f72006_7259_4e4d_9c0c_d2f5a7ae8c44
is encoded by: hsa:2653
name: GCSH
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: P23434
constant: false
initial concentration: NaN

metaR EX CE5867 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-acetyl-seryl-aspartyl-lysyl-proline exchange
type: Reaction

metaR GTHOm
is described by: ECO:0000254
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.8.1.7
name: glutathione oxidoreductase
modifier: MODEL1310110004#
is: SBO:0000176
fast: false
product: MODEL1310110004#
reversible: false
reactant: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2

metaM hs l
is: SBO:0000247
initial concentration: 1.0
type: Species
name: heparan sulfate, free chain
boundary condition: false
has only substance units: false
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
initial amount: NaN
is: CHEBI:28815
constant: false

metaR SERDGLNexR
modifier: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
is described by: ECO:0000304
reversible: true
name: D-Serine/Glutamine reversible exchange
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false

metaM co c
initial concentration: 1.0
is: CHEBI:17245
boundary condition: false
has only substance units: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
initial amount: NaN
is: HMDB01361
name: carbon monoxide

http://identifiers.org/biomodels.db/MODEL1310110004#_33cace5b_7a63_458f_8cea_cbe138ba397c
initial amount: NaN
name: NME3
type: Species
boundary condition: true
is encoded by: hsa:4832
is: SBO:0000252
is: Q13232
has only substance units: false
initial concentration: NaN
constant: false

metaM gchola e
constant: false
boundary condition: false
name: glycocholate
is: HMDB00138
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C26H43NO6 CHARGE: 0
type: Species

metaM tetdec2coa c
initial amount: NaN
initial concentration: 1.0
name: tetradecadienoylcoa
has only substance units: false
is: SBO:0000247
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
boundary condition: false
constant: false
is: HMDB02014
type: Species

metaM dadp n
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB01508
boundary condition: false
constant: false
name: dADP(3-)
initial concentration: 1.0
is: CHEBI:57667
type: Species
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

metaM lnlncg e
name: gamma-linolenate
is: HMDB03073
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:32391

http://identifiers.org/biomodels.db/MODEL1310110004#_7f2da28c_b1a3_46e0_abd5_1dbb7814ef99
boundary condition: true
is encoded by: hsa:79087
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is: Q9BV10
name: ALG12
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_02cac1ea_e055_40be_b739_f69af3b46432
has only substance units: false
is: Q92820
constant: false
is: SBO:0000252
is encoded by: hsa:8836
boundary condition: true
initial concentration: NaN
name: GGH
type: Species
initial amount: NaN

metaR ACGAMK
reactant: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
name: N-acetylglucosamine kinase
product: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.7.1.59
is described by: ECO:0000269
reversible: false
is: SBO:0000176

metaM dttp n
is: CHEBI:37568
is: HMDB01342
constant: false
is: C00459
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
boundary condition: false
type: Species
name: dTTP
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM core4 g
initial concentration: 1.0
has only substance units: false
name: Core 4
is: CHEBI:16478
notes: FORMULA: C24H40N3O15X CHARGE: 0
constant: false
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaM accoa g
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
name: acetyl-CoA(4-)
is: HMDB01206
initial amount: NaN
constant: false
is: CHEBI:57288
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024

metaM dump c
constant: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
name: dUMP
is: CHEBI:246422
is: HMDB01409
type: Species
is: C00365
is: SBO:0000247

metaM 3hpcoa m
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: 3-hydroxypropanoyl-CoA(4-)
initial amount: NaN
has only substance units: false
is: HMDB06807
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
type: Species
is: CHEBI:58528

http://identifiers.org/biomodels.db/MODEL1310110004#_f5a10124_f8ed_49d4_9bf7_20751939684d
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:NM 013421
initial concentration: NaN
name: _NM_013421_1_m

http://identifiers.org/biomodels.db/MODEL1310110004#_e4daae8f_4c8b_4a55_9fd8_ce4d576d48d8
boundary condition: true
name: SLC6A4
is: P31645
constant: false
is encoded by: hsa:6532
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species

metaM udp g
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
is: CHEBI:58223
boundary condition: false
name: UDP(3-)
is: SBO:0000247
is: HMDB00295
initial amount: NaN
constant: false

metaR KCC2t
is: SBO:0000185
product: MODEL1310110004#
name: K+-Cl- cotransporter (NH4+)
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110004#
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110004#_ac4d3f8a_4be0_48de_80b4_b61c0dbe6452
is: P36957
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: DLST
is encoded by: hsa:1743

metaM acac e
has only substance units: false
boundary condition: false
name: acetoacetate
constant: false
is: HMDB00060
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705
initial amount: NaN
type: Species
initial concentration: 1.0

metaM acetone m
initial amount: NaN
is: CHEBI:15347
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: HMDB01659
constant: false
boundary condition: false
name: acetone
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaM co e
constant: false
is: CHEBI:17245
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
is: HMDB01361
name: carbon monoxide

http://identifiers.org/biomodels.db/MODEL1310110004#_a3d4422e_d5f5_452c_8708_e92a971375b8
name: GGT7
constant: false
initial amount: NaN
type: Species
is: A0PJJ9
is encoded by: hsa:2686
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110004#_9e100ac2_484d_4f54_a8d4_3648937dd6fd
boundary condition: true
is: P78356
constant: false
is encoded by: hsa:8396
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
name: PIP4K2B

metaM dttp m
is: C00459
initial amount: NaN
has only substance units: false
boundary condition: false
name: dTTP
initial concentration: 1.0
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
is: CHEBI:37568
type: Species
is: HMDB01342

metaM 42A3HP24DB c
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7956
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
initial amount: NaN
is: C05645
constant: false
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
boundary condition: false
initial concentration: 1.0
is: HMDB04083
has only substance units: false

metaM dolglcp L r
initial concentration: 1.0
type: Species
constant: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
is: CHEBI:15812
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1

metaR DESAT18 4
is: SBO:0000176
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)
is version of: http://identifiers.org/ec-code/1.14.19.1
reversible: false
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110004#_11f444b1_9f0c_45e8_907b_39489abeef03
constant: false
initial amount: NaN
initial concentration: NaN
name: SLC3A2
is: SBO:0000252
is: P08195
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:6520

metaM lnlncg c
is: CHEBI:32391
is: HMDB03073
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
constant: false
name: gamma-linolenate
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-

http://identifiers.org/biomodels.db/MODEL1310110004#_a02a8f25_7c23_4fef_aba7_7d64ced56848
is: Q96CA6
name: ACAA1
boundary condition: true
initial amount: NaN
is encoded by: hsa:30
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252

metaR RE1691M
is version of: http://identifiers.org/ec-code/2.8.1.1
name: RE1691
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
fast: false
product: MODEL1310110004#
kinetic law: MODEL1310110004#

metaR TTDCAtr
is: SBO:0000185
reversible: true
name: tetradecanoate (transport)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
type: Reaction

metaM udpg r
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: HMDB00286
is: CHEBI:58367
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species

metaR FAOXC164C143x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)x
type: Reaction

metaR 5MTHFt2le
product: MODEL1310110004#
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000185
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: 5-methyltetrahydrofolate transport via anion exchange

metaR TYMSFt
product: MODEL1310110004#
is: SBO:0000185
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
fast: false
is described by: ECO:0000000
name: Tyramine O-sulfate transport (diffusion)
reversible: false
reactant: MODEL1310110004#
type: Reaction

metaM ksi pre36 g
constant: false
initial amount: NaN
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
name: keratan sulfate I biosynthesis, precursor 36
is: SBO:0000247
type: Species
is: CHEBI:28067
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR C51CPT1
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tiglylcarnitine
type: Reaction

metaM acac c
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: SBO:0000247
constant: false
is: HMDB00060
initial concentration: 1.0
boundary condition: false
is: CHEBI:13705
has only substance units: false
initial amount: NaN
name: acetoacetate

http://identifiers.org/biomodels.db/MODEL1310110004#_c2713d35_c582_4179_8edb_4df2ac67db45
is encoded by: hsa:7358
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is: O60701
boundary condition: true
name: UGDH
type: Species

metaR ACOAD9m
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
kinetic law: MODEL1310110004#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
modifier: MODEL1310110004#
reactant: MODEL1310110004#
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
product: MODEL1310110004#
reversible: false

metaR FAOXTC102C101m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_2ceb05c7_83ae_4a12_8bfc_9804995e67fb
name: NDUFV1
has only substance units: false
is: E5KNH5
is encoded by: hsa:4723
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaR DGAT
is: SBO:0000176
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
is version of: http://identifiers.org/ec-code/2.3.1.20
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
fast: false
reversible: false
modifier: MODEL1310110004#
is described by: ECO:0000000
name: diacylglycerol acyltransferase
type: Reaction

metaM ksii core2 pre3 g
boundary condition: false
initial concentration: 1.0
is: CHEBI:58053
is: HMDB00175
constant: false
is: C00130
type: Species
name: keratan sulfate II biosynthesis, precursor 3
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C47H76N4O33X CHARGE: -1
has only substance units: false

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR EX leuktrC4 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Leukotriene C4 exchange
type: Reaction

metaM c8dc c
type: Species
is: C02838
has only substance units: false
initial amount: NaN
notes: FORMULA: C15H26NO6 CHARGE: -1
name: suberyl carnitine
is: HMDB00791
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false

metaR ACETONEt2m
reactant: MODEL1310110004#
is: SBO:0000185
kinetic law: MODEL1310110004#
product: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
modifier: MODEL1310110004#
name: acetone mitochondrial transport via proton symport
reversible: true

metaR LNELDCCPT2
kinetic law: MODEL1310110004#
is described by: ECO:0000000
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176
type: Reaction
name: carnitine transferase
fast: false
reversible: false
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110004#

metaR FAOXC81C61x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

metaR FAOXC15C13m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C15-->C13)m
type: Reaction

metaM dadp m
has only substance units: false
name: dADP(3-)
initial amount: NaN
is: HMDB01508
is: CHEBI:57667
type: Species
is: SBO:0000247
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0
boundary condition: false
constant: false

metaM udp l
is: SBO:0000247
initial concentration: 1.0
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
has only substance units: false
name: UDP(3-)
type: Species
initial amount: NaN
boundary condition: false
constant: false

metaR TDCHOLAte
type: Reaction
name: bile acid intracellular transport
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110004#
is: SBO:0000185
reversible: true
product: MODEL1310110004#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_076f9ad6_e5fe_42a5_a824_625b2af04cda
name: C15orf33
boundary condition: true
initial amount: NaN
is: Q96M60
has only substance units: false
is encoded by: hsa:196951
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_e2a8f938_c01b_4f88_90d1_99b7eca00124
is encoded by: hsa:641372
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q3I5F7
is: SBO:0000252
has only substance units: false
constant: false
name: ACOT6
type: Species

metaR GASNASEly
name: glycosylasparaginase, lysosomal
reversible: false
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.5.1.26
fast: false
is: SBO:0000176

metaR GLYPHEHYc
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
is: SBO:0000176
reactant: MODEL1310110004#
fast: false
is described by: ECO:0000134
type: Reaction
name: hydrolysis of glycylphenylalanine
kinetic law: MODEL1310110004#
product: MODEL1310110004#

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM hexdectecoa m
name: 2,4,7,10-hexadecatetraenoylcoa
initial concentration: 1.0
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB02288
has only substance units: false

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

metaM hexdicoa r
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
is: SBO:0000247
is: C08260
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
is: HMDB00672
name: hexadecanedioylcoa

http://identifiers.org/biomodels.db/MODEL1310110004#_0dfba421_59a7_481c_b00b_60c81b7a8be3
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is encoded by: hsa:7991
initial amount: NaN
type: Species
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000297

metaR EX fe3 LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Fe3+ exchange
type: Reaction

metaM 5oxpro c
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57606
name: 5-oxoprolinate
type: Species
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
is: HMDB00267

metaM 5oxpro e
is: SBO:0000247
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:57606
constant: false
name: 5-oxoprolinate
initial concentration: 1.0
is: HMDB00267
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_95afb103_b197_4a9b_84ab_a12f9a9d3cb4
is: P46459
name: NSF
boundary condition: true
initial amount: NaN
is encoded by: hsa:4905
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
constant: false

metaR HS4ly
type: Reaction
name: heparan-N-sulfatase, lysosomal
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.10.1.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
modifier: MODEL1310110004#
fast: false
product: MODEL1310110004#
is: SBO:0000176
reactant: MODEL1310110004#
reversible: false

metaM HC01415 m
constant: false
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: (2E)-Octenoyl-CoA
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
is: CHEBI:27537

http://identifiers.org/biomodels.db/MODEL1310110004#_0d77cfa6_f980_41e4_bf02_362f0687aa29
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3162
name: HMOX1
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q6FH11

metaM gchola c
has only substance units: false
type: Species
initial concentration: 1.0
name: glycocholate
constant: false
is: SBO:0000247
is: HMDB00138
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
boundary condition: false
is: CHEBI:58235
initial amount: NaN

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_0340ac0a_f13d_4df0_aaec_98847b276bda
is encoded by: hsa:2352
is: Q05C14
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
has only substance units: false
name: FOLR3
boundary condition: true

metaM xol7ah2al c
has only substance units: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: CHEBI:27428
is: SBO:0000247
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: HMDB06894

http://identifiers.org/biomodels.db/MODEL1310110004#_6bc8be91_2820_4499_8335_27ba090d7b4f
is: O95340
boundary condition: true
has only substance units: false
initial amount: NaN
name: PAPSS2
initial concentration: NaN
is encoded by: hsa:9060
type: Species
constant: false
is: SBO:0000252

metaR 4NPHSFte
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
reversible: true
fast: false
product: MODEL1310110004#
is: SBO:0000185
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
type: Reaction
name: xenobiotic transport

metaR RE3218C
fast: false
reactant: MODEL1310110004#
product: MODEL1310110004#
name: RE3218
is described by: ECO:0000000
modifier: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.2
kinetic law: MODEL1310110004#
reversible: true

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM ksi deg1 e
is: CHEBI:17268
name: keratan sulfate I, degradation product 1
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00211

http://identifiers.org/biomodels.db/MODEL1310110004#_3a1c3ef6_d80c_4994_a80d_f3f1e39b8379
is: P07451
is: SBO:0000252
name: CA3
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:761

http://identifiers.org/biomodels.db/MODEL1310110004#_dfa941ca_09b1_4162_82b6_25ac991d04e9
is: P25705
has only substance units: false
is encoded by: hsa:498
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ATP5A1

metaR ITCOAL1m
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
product: MODEL1310110004#
is described by: ECO:0000304
modifier: MODEL1310110004#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4

metaM CE5117 m
boundary condition: false
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57923
has only substance units: false
constant: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_9ef35c1a_f36d_4637_a8f0_1248138e25bb
is: SBO:0000252
is encoded by: hsa:5277
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: PIGA
constant: false
has only substance units: false
is: B3KUV7
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_9a44425c_f67a_4660_b241_055fbc7758d2
is: SBO:0000252
is encoded by: hsa:5279
initial amount: NaN
name: PIGC
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true

metaM udp n
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:58223
is: SBO:0000247
has only substance units: false
name: UDP(3-)
type: Species

metaR PIPLCn
reactant: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol phospholipase C, nucleus
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
modifier: MODEL1310110004#
is described by: ECO:0000000
fast: false

metaR GLNS
is described by: ECO:0000254
kinetic law: MODEL1310110004#
type: Reaction
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.15
modifier: MODEL1310110004#
product: MODEL1310110004#
name: glutamine synthetase
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110004#

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaM acetone c
name: acetone
is: SBO:0000247
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial amount: NaN
has only substance units: false
is: CHEBI:15347
type: Species
is: HMDB01659
constant: false
boundary condition: false
initial concentration: 1.0

metaR r1962
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110004#
type: Reaction
name: Y+LAT2 Utilized transport

metaR S23T4g
type: Reaction
reactant: MODEL1310110004#
product: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110004#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.99.4
kinetic law: MODEL1310110004#
name: beta-galactoside alpha-2,3-sialyltransferase

metaM ribflv e
name: Riboflavin
is: C00255
is: CHEBI:3554
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
boundary condition: false
is: HMDB00244
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_323ed6c4_8a2c_47bc_9c43_83a32082ab69
is: SBO:0000252
is encoded by: hsa:5538
constant: false
type: Species
boundary condition: true
is: Q6FGQ4
has only substance units: false
name: PPT1
initial concentration: NaN
initial amount: NaN

metaM citr L e
is: SBO:0000247
is: HMDB00904
initial amount: NaN
boundary condition: false
type: Species
name: citr_L[e]
is: CHEBI:16349
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
constant: false

metaM ivcrn e
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C12H23NO4 CHARGE: 0
boundary condition: false
name: isovaleryl carnitine
has only substance units: false
initial concentration: 1.0
is: HMDB00688
type: Species

metaM CE5101 m
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
has only substance units: false
is: CHEBI:57795
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
type: Species

metaM ddsmsterol r
is: CHEBI:27910
is: HMDB03896
type: Species
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
initial amount: NaN
boundary condition: false
name: 7-dehydrodesmosterol

metaR Coqe
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of q10
reactant: MODEL1310110004#
is described by: ECO:0000134
product: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
is: SBO:0000185
reversible: true

metaR r1302
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
kinetic law: MODEL1310110004#
product: MODEL1310110004#
name: Vesicular transport
reversible: true

metaR ABO9g
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
modifier: MODEL1310110004#
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110004#
fast: false
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
is described by: ECO:0000269
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.1.37
product: MODEL1310110004#

metaM sphs1p r
is: SBO:0000247
type: Species
is: HMDB00277
initial amount: NaN
is: CHEBI:60119
initial concentration: 1.0
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
has only substance units: false
name: sphingosine 1-phosphate(1-)
boundary condition: false
constant: false

metaR r1418
is: SBO:0000176
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
reactant: MODEL1310110004#
fast: false
type: Reaction
is described by: ECO:0000000

metaM biliverd c
initial concentration: 1.0
name: biliverdin(2-)
constant: false
notes: FORMULA: C33H32N4O6 CHARGE: -2 INCHI: InChI=1S/C33H34N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-15,35H,1-2,9-12H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14-,28-15- EHMN_ABBREVIATION: C00500
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:57991
is: HMDB01008
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_28f2894a_60e0_4aaa_b960_494fbe598c2c
is encoded by: hsa:257068
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: Q0VAA5
is: SBO:0000252
boundary condition: true
name: PLCXD2

metaR GALNTg
is version of: http://identifiers.org/ec-code/2.4.1.41
fast: false
reversible: false
reactant: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
is: SBO:0000176
modifier: MODEL1310110004#
is described by: ECO:0000000
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
name: GalNAc transferase, Golgi apparatus

metaR LNELDCCPT1
modifier: MODEL1310110004#
is: SBO:0000176
name: carnitine O-palmitoyltransferase
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_095e0990_ca41_40f0_8d5c_0e58d969b9ef
is: SBO:0000252
initial concentration: NaN
name: PDE7A
is encoded by: hsa:5150
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaR AKR1D2
product: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.1.3
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
is described by: ECO:0000269
reactant: MODEL1310110004#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110004#_e69de111_16f3_479e_8159_3860b20ba892
name: VNN2
boundary condition: true
initial amount: NaN
is encoded by: hsa:8875
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is: O95498
has only substance units: false

metaR r1961
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110004#
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
reactant: MODEL1310110004#
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110004#
product: MODEL1310110004#

metaR CYTDtm
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
type: Reaction
modifier: MODEL1310110004#
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110004#
is described by: ECO:0000269
product: MODEL1310110004#
name: cytidine facilated transport in mitochondria

metaR ILEt4
modifier: MODEL1310110004#
type: Reaction
reversible: false
name: L-isoleucine transport in via sodium symport
is: SBO:0000185
reactant: MODEL1310110004#
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110004#
is described by: ECO:0000304
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_2840539f_c508_4729_b0ee_307396673f39
is: SBO:0000252
initial amount: NaN
name: ATP2B2
is encoded by: hsa:491
constant: false
is: Q4J699
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_e77b4856_2b0c_451f_8228_36a05d3955be
name: NPR1
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:4881
is: P16066
initial amount: NaN
has only substance units: false

metaR LEUKTRB4t
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110004#
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110004#
reactant: MODEL1310110004#
name: leukotriene B4 transport

http://identifiers.org/biomodels.db/MODEL1310110004#_4159ab52_40c2_4159_b50e_08e31a5b8fb6
name: ALDH2
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
is: P05091
has only substance units: false
constant: false
is encoded by: hsa:217

http://identifiers.org/biomodels.db/MODEL1310110004#_077afc7b_e5d9_46a3_94a5_de3e5bf95a8a
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
name: GLB1
is encoded by: hsa:2720
initial concentration: NaN
is: P16278
constant: false

metaM acetone e
type: Species
initial amount: NaN
name: acetone
has only substance units: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
boundary condition: false
is: SBO:0000247
is: CHEBI:15347
initial concentration: 1.0
is: HMDB01659
constant: false

metaM ivcrn c
is: HMDB00688
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C12H23NO4 CHARGE: 0
boundary condition: false
has only substance units: false
constant: false
name: isovaleryl carnitine
initial concentration: 1.0
type: Species

metaR H3ETer
product: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
kinetic law: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
is: SBO:0000176
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum
reversible: false
is described by: ECO:0000304
fast: false

metaM citr L c
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00904
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:16349
name: L-citrulline
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0

metaM ksi pre29 g
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
name: keratan sulfate I biosynthesis, precursor 29
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:28067
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110004#_e3888941_cb30_48ec_9874_ee0ea9b60c04
is: SBO:0000252
name: FOLR1
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:2348
constant: false
is: P15328

http://identifiers.org/biomodels.db/MODEL1310110004#_22783f72_4a1d_4f4c_af36_37f96d05521c
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:1757
has only substance units: false
initial amount: NaN
is: A8K596
initial concentration: NaN
name: SARDH

metaM mthgxl c
initial concentration: 1.0
name: methylglyoxal
is: CHEBI:17158
initial amount: NaN
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
has only substance units: false
constant: false
boundary condition: false
is: HMDB01167
is: SBO:0000247
type: Species

metaR GLCNACASE3ly
name: alpha-N-acetylglucosaminidase, lysosomal
fast: false
product: MODEL1310110004#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110004#
reversible: false
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110004#
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.50

http://identifiers.org/biomodels.db/MODEL1310110004#_33b98b04_3298_4684_b45a_3faf2b6f8618
is: P23368
is: SBO:0000252
boundary condition: true
type: Species
name: ME2
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:4200

metaR GALSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
fast: false
product: MODEL1310110004#
reversible: true
kinetic law: MODEL1310110004#
name: galactocerebroside intracellular transport
is: SBO:0000185
reactant: MODEL1310110004#
is described by: ECO:0000000
type: Reaction

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

metaR DDECE1CRNe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

metaM m4mpdol U r
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
is: CHEBI:37633
type: Species
boundary condition: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
has only substance units: false

metaR IDOAASE3ly
kinetic law: MODEL1310110004#
fast: false
product: MODEL1310110004#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.76
reactant: MODEL1310110004#
is: SBO:0000176
name: alpha-L-iduronidase, lysosomal
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_b29d8180_c0a7_40a4_a264_201883966285
constant: false
name: PHPT1
is: SBO:0000252
is: Q9P019
boundary condition: true
is encoded by: hsa:29085
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110004#_ac806972_b935_4a33_bbe6_f0c8d7b6a79b
initial concentration: NaN
is: Q6NZ59
has only substance units: false
is encoded by: hsa:522
initial amount: NaN
boundary condition: true
type: Species
name: ATP5J
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_9dc1b2f1_ecdb_45e3_9341_de9c396350f3
name: SULT1A1
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6817
type: Species
has only substance units: false

metaR ATP1ter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110004#
type: Reaction
fast: false
reversible: true
product: MODEL1310110004#
is described by: ECO:0000000
name: ADP/ATP transporter, endoplasmic reticulum
is: SBO:0000185
kinetic law: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_d5e3ba7e_d894_4a3c_98c7_284ab4cf712d
initial amount: NaN
has part: B4E3E9
is encoded by: hsa:4967
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
name: DLD:DLST:OGDH:PDHX
type: Species
is: SBO:0000297

http://identifiers.org/biomodels.db/MODEL1310110004#_ae1f3bb6_7ad3_49eb_bb7d_1daf7e14b924
constant: false
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5336
initial amount: NaN
is: P16885
name: PLCG2
boundary condition: true
is: SBO:0000252

metaM udp r
is: HMDB00295
is: SBO:0000247
name: UDP
constant: false
is: CHEBI:58223
boundary condition: false
is: C00015
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110004#_9c3a1e87_521a_42b1_9f56_4615b716f85e
has only substance units: false
initial concentration: NaN
name: CRAT
initial amount: NaN
constant: false
is encoded by: hsa:1384
is: SBO:0000252
boundary condition: true
is: P43155
type: Species

metaR DOLPMT U
reversible: false
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
modifier: MODEL1310110004#
type: Reaction
name: Dolichyl-phosphate D-mannosyltransferase (uterus)
reactant: MODEL1310110004#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.83
kinetic law: MODEL1310110004#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110004#_cc6a9024_ae67_4348_acb3_4b7b422fe616
constant: false
initial amount: NaN
is encoded by: hsa:8818
boundary condition: true
name: DPM2
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaM icit m
initial amount: NaN
is: HMDB00193
type: Species
name: Isocitrate
is: CHEBI:16087
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: C00311
is: SBO:0000247
constant: false

metaR GALSIDEtl
name: galactocerebroside intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
product: MODEL1310110004#
kinetic law: MODEL1310110004#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110004#
reversible: true
type: Reaction

metaM 3decdicoa m
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
constant: false
initial amount: NaN
name: 3,7-decadienoylcoa
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
type: Species
is: SBO:0000247

metaR MI3PP
kinetic law: MODEL1310110004#
name: myo-inositol 3-phosphatase
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
fast: false
reversible: false
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.3.25
product: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:NCD

metaM dectricoa x
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
name: 2,4,7-decatrienoylcoa
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966

metaR VITD3t2
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110004#
type: Reaction
product: MODEL1310110004#
name: Vitamin D3 uptake
fast: false
reactant: MODEL1310110004#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT

metaM psylchol e
name: psillium-glycocholic acid complex
initial amount: NaN
is: http://identifiers.org/pubchem.compound/97364
constant: false
is: SBO:0000247
notes: FORMULA: C9642032H15428743NO8667420 CHARGE: 0
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species

metaR DHCR243r
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
is described by: ECO:0000134
reactant: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/1.3.1.72
type: Reaction
fast: false
is: SBO:0000176
name: 24-dehydrocholesterol reductase [Precursor]
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: false

metaM retinol 9 cis c
is: SBO:0000247
is: CHEBI:17336
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: 9-cis-retinol
is: HMDB06217
has only substance units: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_04b5317b_f82e_47f9_8956_73311a0b4691
is: Q8IZH9
name: GCH1
initial amount: NaN
is encoded by: hsa:2643
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

metaR LNLCCRNt
kinetic law: MODEL1310110004#
fast: false
product: MODEL1310110004#
reversible: false
modifier: MODEL1310110004#
reactant: MODEL1310110004#
name: transport into the mitochondria (carnitine)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
type: Reaction

metaM dhea c
has only substance units: false
is: HMDB00077
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
name: 3beta-hydroxyandrost-5-en-17-one
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
is: CHEBI:28689

metaR ARACHDCOAtx
reversible: true
type: Reaction
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110004#
fast: false
name: fatty acid intracellular transport

metaM c5dc e
constant: false
name: glutaryl carnitine
boundary condition: false
notes: FORMULA: C12H21NO6 CHARGE: 0
is: SBO:0000247
type: Species
is: HMDB13130
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaR NACHEX13ly
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
is described by: ECO:0000000
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110004#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_95310267_cacd_41c4_aa6f_d2b4ac31e7f7
initial amount: NaN
boundary condition: true
type: Species
name: HADH
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:3033
initial concentration: NaN
is: Q16836

metaR FAOXC17C15m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C17-->C15)m
type: Reaction

metaM accoa c
constant: false
is: C00024
is: CHEBI:57288
has only substance units: false
initial amount: NaN
name: Acetyl-CoA
is: HMDB01206
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110004#_b7cf762a_276b_437c_886d_60d3a9ed959b
is: P09417
initial amount: NaN
is encoded by: hsa:5860
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: QDPR

metaR HGNTOR
product: MODEL1310110004#
reactant: MODEL1310110004#
reversible: false
is version of: http://identifiers.org/ec-code/1.13.11.5
fast: false
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
type: Reaction
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
is: SBO:0000176
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#

metaR r0560
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
product: MODEL1310110004#
kinetic law: MODEL1310110004#
reversible: false
reactant: MODEL1310110004#
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
type: Reaction

metaR r1301
fast: false
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110004#
name: Vesicular transport
type: Reaction
kinetic law: MODEL1310110004#
reversible: false
is: SBO:0000185

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaR PI345P5P
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
product: MODEL1310110004#
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
reversible: false
modifier: MODEL1310110004#
type: Reaction
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.3.36
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
fast: false
is: SBO:0000176

metaR RE3524R
reversible: true
product: MODEL1310110004#
type: Reaction
is described by: ECO:0000000
name: RE3524
kinetic law: MODEL1310110004#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
fast: false
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_ba873cb3_5197_4dfa_9510_c514971c44f5
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: P49327
type: Species
has only substance units: false
name: FASN
boundary condition: true
is encoded by: hsa:2194

http://identifiers.org/biomodels.db/MODEL1310110004#_5a0a1241_ade9_4037_8f1a_e15cb595dda4
is: P50226
initial concentration: NaN
is: SBO:0000252
name: SULT1A2
initial amount: NaN
boundary condition: true
is encoded by: hsa:6799
has only substance units: false
constant: false
type: Species

metaR NRPPHRtu
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000269
product: MODEL1310110004#
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
name: Norepinephrine uniport

metaR DESAT24 1
is: SBO:0000176
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
reversible: false
product: MODEL1310110004#
fast: false
modifier: MODEL1310110004#
name: fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)
is described by: ECO:0000269
kinetic law: MODEL1310110004#
type: Reaction

metaM nadp c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
name: Nicotinamide adenine dinucleotide phosphate
constant: false
initial amount: NaN
is: HMDB00217
has only substance units: false
is: C00006

metaM eitetcoa m
name: 5,8,11,14-eicosatetraenoylcoa
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C41H62N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
has only substance units: false
constant: false
type: Species
boundary condition: false

metaR FAOXC121C101m
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:1-->C10:1)m
type: Reaction

metaR UGT1A10r
reactant: MODEL1310110004#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.17
product: MODEL1310110004#
type: Reaction
modifier: MODEL1310110004#
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
is described by: ECO:0000134
is: SBO:0000176
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified

metaR UMPK5n
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110004#
type: Reaction
kinetic law: MODEL1310110004#
is described by: ECO:0000269
is: SBO:0000176
name: UMP kinase (dATP),nuclear
reversible: true
modifier: MODEL1310110004#
reactant: MODEL1310110004#

http://identifiers.org/biomodels.db/MODEL1310110004#_9379ccbe_0cae_478a_a9b0_9198071af3c8
has only substance units: false
initial concentration: NaN
is: F8WDN9
type: Species
constant: false
is encoded by: hsa:27068
initial amount: NaN
name: PPA2
is: SBO:0000252
boundary condition: true

metaM ribflv c
initial amount: NaN
type: Species
is: C00255
is: CHEBI:3554
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial concentration: 1.0
is: HMDB00244
name: Riboflavin

metaR AMACR2p
name: alpha-methylacyl-CoA racemase (reductase)
product: MODEL1310110004#
reactant: MODEL1310110004#
modifier: MODEL1310110004#
is described by: ECO:0000304
reversible: false
notes: GENE_ASSOCIATION: (23600.1) or (23600.2) SUBSYSTEM: Bile acid synthesis EC Number: 5.1.99.4 Confidence Level: 2 AUTHORS: NOTES:should be analogous to AMACRp as per KEGG - in this case: reductase not a racemase NJ
is version of: http://identifiers.org/ec-code/5.1.99.4
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110004#
fast: false

metaR TYRTA
is: SBO:0000176
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reversible: true
fast: false
name: tyrosine transaminase
is described by: ECO:0000269
product: MODEL1310110004#
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
modifier: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.6.1.1

metaR r1964
type: Reaction
is: SBO:0000185
product: MODEL1310110004#
is described by: ECO:0000000
reactant: MODEL1310110004#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110004#
kinetic law: MODEL1310110004#
name: Y+LAT2 Utilized transport

metaR PTPATe
product: MODEL1310110004#
reversible: true
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110004#
is: SBO:0000176
type: Reaction
name: PTPATe
reactant: MODEL1310110004#

metaR r1744
type: Reaction
is described by: ECO:0000000
product: MODEL1310110004#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false
kinetic law: MODEL1310110004#
is: SBO:0000185
modifier: MODEL1310110004#
reactant: MODEL1310110004#
reversible: false

metaR C141OHe
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C14:1-OH
type: Reaction

metaM h2o m
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
is: C00001
constant: false
name: H2O
is: CHEBI:15377
is: HMDB02111
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR r1633
kinetic law: MODEL1310110004#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110004#
is described by: ECO:0000000
is: SBO:0000185

metaR r0571
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.17 Confidence Level: 0 AUTHORS: PMID:3071714,PMID:6885824 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.8
reversible: true
kinetic law: MODEL1310110004#
is described by: ECO:0000000
reactant: MODEL1310110004#
is: SBO:0000176
product: MODEL1310110004#
name: (S)-Methylmalonyl-CoA hydrolase Propanoate metabolism EC:3.1.2.17
modifier: MODEL1310110004#
fast: false
type: Reaction

metaR r2376
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110004#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#

metaM his L e
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: L-histidine
is: CHEBI:15971
type: Species
is: HMDB00177
constant: false
initial concentration: 1.0
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
has only substance units: false

metaM xol7ah2al m
is: HMDB06894
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:27428
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110004#_582f9bb4_dcac_47d0_8738_608a401f237d
is encoded by: hsa:10637
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: LEFTY1
is: O75610
has only substance units: false

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_8fb89f38_355d_490f_a942_d44d180273e6
initial amount: NaN
is: Q93099
is encoded by: hsa:3081
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
name: HGD

metaR r0570
is described by: ECO:0000000
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
reversible: true
is: SBO:0000176
reactant: MODEL1310110004#
is version of: http://identifiers.org/ec-code/6.3.3.2
modifier: MODEL1310110004#
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
product: MODEL1310110004#
fast: false
kinetic law: MODEL1310110004#
type: Reaction

metaR MG3er
type: Reaction
fast: false
kinetic law: MODEL1310110004#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
is described by: ECO:0000000
reactant: MODEL1310110004#
reversible: false
is: SBO:0000176
product: MODEL1310110004#

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110004#_b7ce880a_156a_4e3b_9e48_e22c9dfa5b4a
boundary condition: true
constant: false
type: Species
is encoded by: hsa:1607
is: SBO:0000252
has only substance units: false
name: DGKB
initial amount: NaN
initial concentration: NaN

metaR r1634
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110004#
fast: false
reactant: MODEL1310110004#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110004#
reversible: true

metaM adrncoa x
type: Species
is: C16170
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205480
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
name: adrenyl coenzyme A
boundary condition: false
constant: false
initial concentration: 1.0

metaM h2o n
boundary condition: false
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
is: SBO:0000247
initial concentration: 1.0
is: HMDB02111
initial amount: NaN
name: water
type: Species
constant: false

metaM em2emgacpail hs r
notes: FORMULA: C53H100N3O35P3FULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
is: CHEBI:16240
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB03125
boundary condition: false
constant: false
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)

metaR FAOXC5C3x
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C5-->C3)m
type: Reaction

metaM 2mb2coa c
name: 2-methylcrotonoyl-CoA(4-)
constant: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1
is: SBO:0000247
initial amount: NaN
is: HMDB02054
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false

metaR r2377
fast: false
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110004#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110004#
reactant: MODEL1310110004#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction

metaR C30CPT1
kinetic law: MODEL1310110004#
product: MODEL1310110004#
reactant: MODEL1310110004#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of propionylcarnitine
type: Reaction

metaM 5tedtricoa m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB02288
initial amount: NaN
name: 5,8,11-tetradecatrienoylcoa
constant: false
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4

metaM so3 c
initial amount: NaN
type: Species
boundary condition: false
name: Sulfite
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:17137
constant: false
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: HMDB00240
has only substance units: false
is: C00094

metaR GLUPRT
is: SBO:0000176
name: glutamine phosphoribosyldiphosphate amidotransferase
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
is version of: http://identifiers.org/ec-code/2.4.2.14
product: MODEL1310110004#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110004#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110004#_c06687cc_34ab_4cf1_adc1_abb7ce2d3438
has only substance units: false
type: Species
name: _AI435857_1_x
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI435857
constant: false

http://identifiers.org/biomodels.db/MODEL1310110004#_e5087121_0d14_492b_891b_803b15eb379b
initial concentration: NaN
name: OGDH
is: Q02218
is encoded by: hsa:4967
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaR SUCOAS1m
reversible: true
modifier: MODEL1310110004#
is described by: ECO:0000000
type: Reaction
fast: false
name: Succinate--CoA ligase (GDP-forming)
reactant: MODEL1310110004#
kinetic law: MODEL1310110004#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
product: MODEL1310110004#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4

http://identifiers.org/biomodels.db/MODEL1310110004#_d7eeec10_5df1_4842_8b1b_2e78d8e69693
constant: false
is encoded by: hsa:3421
name: IDH3A:IDH3B:IDH3G
is encoded by: hsa:3420
is: SBO:0000297
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
has part: O43837
has part: P51553

http://identifiers.org/biomodels.db/MODEL1310110004#_adab7f53_bc1a_4f2d_8319_301e95dc3ed6
initial amount: NaN
type: Species
has only substance units: false
is: P42765
is encoded by: hsa:10449
initial concentration: NaN
constant: false
is: SBO:0000252
name: ACAA2
boundary condition: true