metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaR CYSGLYexR
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
fast: false
reversible: true
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
name: L-cysteine/glycine reversible exchanger
reactant: MODEL1310110003#
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_ade301b3_0126_4ba5_aa3a_625565281173
initial concentration: NaN
type: Species
is encoded by: hsa:37
is: SBO:0000252
name: ACADVL
is: P49748
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_b2aac495_f463_4bae_a3ee_4499d3d31f34
initial concentration: NaN
constant: false
is: P09622
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
name: DLD
is encoded by: hsa:1738

metaM HC02216 e
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
boundary condition: false
has only substance units: false
name: prostaglandin-f2beta
initial concentration: 1.0
is: CHEBI:28922

http://identifiers.org/biomodels.db/MODEL1310110003#_270bcf08_4e4e_4d62_979f_01fd0b5a3eb3
name: UROC1
type: Species
is: SBO:0000252
boundary condition: true
is: Q68CJ7
is encoded by: hsa:131669
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_92844bb5_141f_4859_a3dd_885eef4c71fe
type: Species
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
name: B3GNT4
is: Q9C0J1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:79369

http://identifiers.org/biomodels.db/MODEL1310110003#_a217de33_4982_4e3b_bcd8_d153e07ea98f
initial concentration: NaN
type: Species
is: Q9H0I9
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:84076
name: TKTL2

metaR GMAND
product: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.47
fast: false
modifier: MODEL1310110003#
name: GDP-D-mannose dehydratase
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR

http://identifiers.org/biomodels.db/MODEL1310110003#_f693193f_d47d_455b_8f82_cbb6746fc086
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P21953
boundary condition: true
name: BCKDHB
constant: false
is encoded by: hsa:594
type: Species
initial amount: NaN

metaR r2100
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r2325
fast: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
product: MODEL1310110003#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110003#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR GLCAASE8ly
type: Reaction
reactant: MODEL1310110003#
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110003#
product: MODEL1310110003#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.31

metaR r1604
product: MODEL1310110003#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110003#

metaM udpgal c
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: HMDB00302
is: CHEBI:58439
name: UDP-D-galactose(2-)

http://identifiers.org/biomodels.db/MODEL1310110003#_16da7508_4b3a_4541_a534_1940a68f105e
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: MAN1A1
is encoded by: hsa:4121
type: Species
boundary condition: true
is: P33908

metaR r2538
fast: false
product: MODEL1310110003#
type: Reaction
name: Utilized transport
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true

metaR RE2972M
kinetic law: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.67
modifier: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
name: RE2972
product: MODEL1310110003#
is: SBO:0000176
fast: false
reactant: MODEL1310110003#

metaM strch2 e
notes: FORMULA: C18H32O16 CHARGE: 0
boundary condition: false
is: CHEBI:4167
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
constant: false
is: HMDB00122
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species

metaM ncam c
constant: false
type: Species
notes: FORMULA: C6H6N2O CHARGE: 0
name: Nicotinamide
is: C00153
boundary condition: false
is: CHEBI:0
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB01406
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_0e665eaf_6f7a_406a_ae7a_397c77ee0a42
is: Q96M32
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:122481
is: SBO:0000252
name: AK7
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_827d8ba7_9238_429b_884f_bc1e20d9ecd1
boundary condition: true
is encoded by: hsa:AA664770
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _AA664770_1_m
constant: false
is: SBO:0000252
type: Species

metaM tdcoa m
boundary condition: false
constant: false
is: CHEBI:57385
type: Species
initial amount: NaN
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: SBO:0000247
is: HMDB01521
has only substance units: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial concentration: 1.0
is: C02593

metaM C02528 c
constant: false
is: SBO:0000247
is: CHEBI:36234
has only substance units: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: HMDB00518
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: chenodeoxycholate
type: Species

metaR PTPATe
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
fast: false
name: PTPATe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true

metaM 2amac c
name: 2-aminoacrylic acid
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C3H5NO2 CHARGE: 0 INCHI: InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00906 EHMN_ABBREVIATION: C02218
type: Species
is: HMDB03609
is: CHEBI:17123
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_195c2962_97ac_4d1c_a062_59bed80605a8
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
name: _AI090874_1_c
is encoded by: hsa:AI090874
is: SBO:0000252

metaM arachdcoa m
initial amount: NaN
initial concentration: 1.0
name: arachidonoyl-CoA(4-)
is: CHEBI:57368
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB06523
constant: false
has only substance units: false
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249

metaR DUTPDPn
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.6.1.23
fast: false
reversible: false
name: dUTP diphosphatase, nuclear
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
modifier: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
is described by: ECO:0000269
is: SBO:0000176

metaR r2324
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaR r2101
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
product: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reversible: true

metaR r1603
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_dc4ff5d0_db65_4375_a538_75864467e61d
is: Q86SF2
has only substance units: false
name: GALNT7
initial amount: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:51809
is: SBO:0000252
initial concentration: NaN

metaR ACACT1rm
is described by: ECO:0000000
modifier: MODEL1310110003#
reactant: MODEL1310110003#
name: acetyl-CoA C-acetyltransferase, mitochondrial
fast: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (3030.1) and (3032.1) or (38.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:TDV
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.9

metaM lthstrl r
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
name: 5alpha-cholest-7-en-3beta-ol
is: CHEBI:17168
constant: false
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
boundary condition: false
is: HMDB01170

metaR AG13T3g
type: Reaction
product: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110003#
reversible: false
is: SBO:0000176
fast: false
modifier: MODEL1310110003#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaM m7masnB g
is: SBO:0000247
notes: FORMULA: C64H107N2O50X CHARGE: 0
constant: false
initial concentration: 1.0
is: C05881
type: Species
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_7a526ce2_60d8_4503_8303_896b1f8b7249
boundary condition: true
is encoded by: hsa:8801
has part: Q96I99
is encoded by: hsa:8802
has only substance units: false
has part: P53597
name: SUCLG2:SUCLG1
initial concentration: NaN
type: Species
is: SBO:0000297
initial amount: NaN
constant: false

metaM uri e
has only substance units: false
type: Species
initial concentration: 1.0
is: CHEBI:16704
is: C00299
boundary condition: false
is: HMDB00296
is: SBO:0000247
constant: false
name: Uridine
initial amount: NaN
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299

http://identifiers.org/biomodels.db/MODEL1310110003#_e0ca511e_4f37_4198_a2de_f9dce1f89c81
constant: false
is encoded by: hsa:23428
name: SLC7A8:SLC3A2
has only substance units: false
is: SBO:0000297
type: Species
initial amount: NaN
boundary condition: true
has part: Q86U05
initial concentration: NaN

metaM sph1p e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB01383
is: CHEBI:57939
type: Species
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_34dfa49b_a1bb_499c_9236_e33e7df0774c
boundary condition: true
has only substance units: false
initial concentration: NaN
name: SLC26A4
is: O43511
is: SBO:0000252
is encoded by: hsa:5172
constant: false
initial amount: NaN
type: Species

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_493975ca_aeba_4d45_b805_cbeb44400684
initial concentration: NaN
name: BDH1
is encoded by: hsa:622
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaM HC02216 c
is: CHEBI:28922
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
name: prostaglandin-f2beta
initial concentration: 1.0

metaM sql r
is: CHEBI:15440
constant: false
is: HMDB00256
initial amount: NaN
is: SBO:0000247
type: Species
name: squalene
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM rib D c
is: CHEBI:16988
is: SBO:0000247
is: HMDB00283
name: D-ribose
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
boundary condition: false

metaM CE4790 m
has only substance units: false
initial concentration: 1.0
is: HMDB00127
type: Species
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
is: SBO:0000247
boundary condition: false
is: CHEBI:15748
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
initial amount: NaN
constant: false

metaR r1606
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110003#
product: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#

metaM gmp c
has only substance units: false
initial amount: NaN
is: C00144
constant: false
is: HMDB01397
name: GMP
type: Species
initial concentration: 1.0
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: SBO:0000247
boundary condition: false
is: CHEBI:58115

metaR PCHOL HSter
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
product: MODEL1310110003#
kinetic law: MODEL1310110003#
name: phosphatidylcholine scramblase
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110003#

metaR r1683
reversible: false
product: MODEL1310110003#
name: Y+LAT2 Utilized transport
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110003#
is described by: ECO:0000000
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#

metaM CE1926 e
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
is: CHEBI:15748
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00127
name: gama-carboxyethyl-hydroxychroman
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR r0553
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110003#
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:

metaR 4HOXPACDOX NADP
reversible: true
product: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
kinetic law: MODEL1310110003#
is: SBO:0000176
reactant: MODEL1310110003#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase

http://identifiers.org/biomodels.db/MODEL1310110003#_2fec4494_bd61_40a8_8fb3_95f917858bb6
is: Q92536
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:9057
constant: false
boundary condition: true
name: SLC7A6

metaR r2327
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110003#
product: MODEL1310110003#

metaR GLYtm
fast: false
name: glycine passive transport to mitochondria
type: Reaction
is described by: ECO:0000000
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
is: SBO:0000185

metaM ncam e
type: Species
notes: FORMULA: C6H6N2O CHARGE: 0
is: C00153
is: CHEBI:0
boundary condition: false
initial amount: NaN
name: Nicotinamide
initial concentration: 1.0
is: HMDB01406
is: SBO:0000247
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_d9f20965_b52f_4448_a855_5c4b13a05c17
type: Species
initial amount: NaN
is: P41247
constant: false
is: SBO:0000252
name: PNPLA4
initial concentration: NaN
has only substance units: false
is encoded by: hsa:8228
boundary condition: true

metaR HEX1
reactant: MODEL1310110003#
reversible: false
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
kinetic law: MODEL1310110003#
name: hexokinase (D-glucose:ATP)
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.1.2
is: SBO:0000176
type: Reaction
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.1.1
fast: false

metaR C204CRNt
name: arachidonic acid transport into the mitochondria
reactant: MODEL1310110003#
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
fast: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
type: Reaction

metaR DTMPK
is: SBO:0000176
fast: false
kinetic law: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.9
reactant: MODEL1310110003#
type: Reaction
name: dTMP kinase
product: MODEL1310110003#

metaM glyphe c
boundary condition: false
initial concentration: 1.0
constant: false
name: Glycylphenylalanine
has only substance units: false
is: http://identifiers.org/pubchem.compound/97415
notes: FORMULA: C11H14N2O3 CHARGE: 0
initial amount: NaN
type: Species
is: SBO:0000247

metaR r2326
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
fast: false
reactant: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110003#

metaR r1605
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110003#
product: MODEL1310110003#
fast: false
type: Reaction
kinetic law: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaM HC01361 e
boundary condition: false
type: Species
name: Dihydroneopterin
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:17001
initial concentration: 1.0
notes: FORMULA: C9H13N5O4 CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 EHMN_ABBREVIATION: C04874
constant: false

metaR r0552
is version of: http://identifiers.org/ec-code/1.3.5.1
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
modifier: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
reversible: true

metaR GLYBtm
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
is: SBO:0000185
reversible: true
name: Glycine betaine transport via diffusion (mitochondria to cytosol)
type: Reaction
reactant: MODEL1310110003#
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_a24d2f2f_6af9_4399_afb3_bc954e45cf05
constant: false
name: SLCO1A2
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P46721
has only substance units: false
is encoded by: hsa:6579
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_034eb4e0_9d50_455b_aa12_e95af4e97669
initial amount: NaN
name: PLCD1
is: P51178
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:5333
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM cyan e
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
type: Species
constant: false
is: HMDB02084
is: SBO:0000247
has only substance units: false
name: hydrogen cyanide
is: CHEBI:18407

metaM dha e
type: Species
initial concentration: 1.0
name: glycerone
constant: false
initial amount: NaN
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
has only substance units: false
is: HMDB01882
is: CHEBI:16016
is: SBO:0000247
boundary condition: false

metaR LYSOXp
fast: false
name: L-lysine oxidase, peroxisomal
is described by: ECO:0000000
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
type: Reaction
product: MODEL1310110003#
reversible: false
is: SBO:0000176
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_c8b4896d_4375_40a3_aaa2_f269c69ce9f1
initial amount: NaN
is encoded by: hsa:2882
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: GPX7
is: Q96SL4

metaR r2321
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
type: Reaction
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185

metaR RTOTALt
reactant: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
reversible: true
name: RTOTAL transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110003#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_5f188b52_0d0e_4d45_8950_2ecd35b89d4d
name: CPT1C
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is: Q8TCG5
is encoded by: hsa:126129

metaM HC01397 m
has only substance units: false
is: CHEBI:27402
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: (S)-3-Hydroxyhexadecanoyl-CoA
constant: false
is: SBO:0000247
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258

http://identifiers.org/biomodels.db/MODEL1310110003#_1057a81b_6ae8_44ae_8f19_48b9e5a2abba
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4706
initial amount: NaN
name: NDUFAB1
is: O14561
type: Species
constant: false
boundary condition: true

metaR r2534
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185
product: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
reactant: MODEL1310110003#
type: Reaction
is described by: ECO:0000000

MODEL1310110003#
species: metaM pe hs c
species: metaM lac L c
species: metaM andrstandn r
species: metaM HC01115 c
species: metaM 3pg m
species: metaM pacald c
species: metaM dhap c
species: metaM acac c
species: metaM hs deg25 l
species: metaM dgdp m
species: metaM pail hs c
species: metaM CE2424 m
species: metaM nh4 c
species: metaM HC02023 r
species: metaM itp c
species: metaM acngalgbside hs g
species: metaM odecoa r
species: metaM btn c
species: metaM retfa e
species: metaM C02470 c
species: metaM citr L e
species: metaM nrpphr e
species: metaM ala D x
species: metaM pail45p hs m
species: metaM hs deg19 l
species: metaM glc D g
species: metaM 3php c
species: metaM gluside hs r
species: metaM asn L e
type: SBMLUnitsDef
species: metaM h2o r
species: metaM CE2433 m
species: metaM amp m
species: metaM udpgal c
species: metaM Lpipecol x
species: metaM duri n
species: metaM ksi pre20 g
species: metaM dag hs n
species: metaM ksi pre2 g
species: metaM 5thf e
species: metaM 4fumacac c
species: metaM xoltetrol c
species: metaM dudp c
species: metaM udp g
species: metaM glcur c
species: metaM arachd e
species: metaM ipdp x
species: metaM eicostetcoa c
species: metaM xol7ah3 m
species: metaM chol n
species: metaM ksi pre23 g
species: metaM leugly c
species: metaM 2dr1p c
species: metaM hdca l
species: metaM 2dr5p c
species: metaM CE2420 m
species: metaM gln L c
stoichiometry: 0.385872
species: metaM 4ppcys c
species: metaM dhlam m
species: metaM taur c
species: metaM pro L e
species: metaM tsul m
species: metaM pi e
species: metaM his L c
species: metaM lpam m
species: metaM ksi pre25 g
species: metaM arach c
species: metaM gthrd e
species: metaM tdchola c
species: metaM ksi pre3 g
species: metaM fol c
species: metaM hs l
species: metaM gal e
species: metaM CE2839 e
species: metaM HC02216 c
species: metaM dcyt n
species: metaM arachcrn c
species: metaM pristcoa x
species: metaM C05280 m

http://identifiers.org/biomodels.db/MODEL1310110003#_cc37f3cb_3698_4d29_9679_a5ebde74209c
is: Q6P1K9
name: PANK2
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:80025
has only substance units: false
initial amount: NaN

metaR LPCOXp
is version of: http://identifiers.org/ec-code/1.5.3.1
fast: false
is described by: ECO:0000269
name: L-pipecolate oxidase, peroxisomal
modifier: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
type: Reaction
reversible: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:

metaM strdnc c
boundary condition: false
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205608
type: Species
is: HMDB06547
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C16300
name: stearidonic acid C18:4, n-3
constant: false

metaM ksii core2 pre1 g
constant: false
boundary condition: false
is: CHEBI:28067
type: Species
notes: FORMULA: C33H53N3O23X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 1
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM dtmp e
name: dTMP(2-)
is: CHEBI:26999
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
type: Species
is: HMDB01227
is: SBO:0000247

metaR RE2349C
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.6.1.64
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
name: RE2349
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:8908429 NOTES:IT - removed H[c] on right hand side even though no charged formula for Kegg compound but same as reaction RE1233C
reversible: true
fast: false
product: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_cb62e2b4_fb65_47dc_8c10_bad2b9492e51
name: UCK1
boundary condition: true
is encoded by: hsa:83549
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: Q5JT09
is: SBO:0000252
initial amount: NaN

metaR DOPAt4 2 r
is described by: ECO:0000269
type: Reaction
product: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
is: SBO:0000185
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
name: Dopamine reversible transport in via sodium symport (1:2)

metaR MTHFCm
modifier: MODEL1310110003#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.3
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:12937168 NOTES:NCD
reactant: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000269
product: MODEL1310110003#
reversible: true
name: methenyltetrahydrifikate cyclohydrolase, mitochondrial
type: Reaction
kinetic law: MODEL1310110003#

metaR r1018
is: SBO:0000185
name: Transport reaction
fast: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
type: Reaction
kinetic law: MODEL1310110003#
reversible: true
is described by: ECO:0000000
product: MODEL1310110003#

metaR r1600
reversible: true
is: SBO:0000185
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110003#
is described by: ECO:0000000
fast: false

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR r0672
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110003#
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
reversible: true
is: SBO:0000176
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
is described by: ECO:0000000
product: MODEL1310110003#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_cdb11b99_da11_4051_af34_f97c7ff54786
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:60482
initial concentration: NaN
boundary condition: true
name: SLC5A7
is: Q9GZV3
constant: false

metaR PRO1xm
is: SBO:0000176
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
reversible: false
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
name: proline oxidase (NAD), mitochondrial
is version of: http://identifiers.org/ec-code/1.5.99.8
is described by: ECO:0000254
product: MODEL1310110003#
fast: false
type: Reaction
modifier: MODEL1310110003#

metaR r2320
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
kinetic law: MODEL1310110003#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM ptrc e
constant: false
has only substance units: false
name: Putrescine
is: SBO:0000247
is: CHEBI:326268
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: C00134
type: Species
is: HMDB01414
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134

metaM oaa m
type: Species
constant: false
is: C00036
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:16452
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
name: Oxaloacetate
is: HMDB00223

metaR r2535
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110003#
fast: false
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_4e6a4741_7fb9_4d3d_9002_9ceb53877daf
name: AFMID
has only substance units: false
constant: false
is: Q63HM1
is encoded by: hsa:125061
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR DOLPMT2 Uer
product: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110003#
fast: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is described by: ECO:0000000

metaM glyphe e
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/97415
name: Glycylphenylalanine
notes: FORMULA: C11H14N2O3 CHARGE: 0
has only substance units: false
is: SBO:0000247
constant: false

metaR LEUKTRE4t
is described by: ECO:0000000
product: MODEL1310110003#
type: Reaction
name: leukotriene E4 transport
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_180d19b0_12b1_444b_833c_e2e6f651ab3a
is: B2RBR4
has only substance units: false
is: SBO:0000252
name: SLC20A2
initial concentration: NaN
is encoded by: hsa:6575
constant: false
boundary condition: true
initial amount: NaN
type: Species

metaM aicar e
initial amount: NaN
notes: FORMULA: C9H13N4O8P CHARGE: -2
type: Species
has only substance units: false
is: HMDB01517
is: CHEBI:58475
constant: false
is: C04677
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_0b75a496_c8cf_4b77_94ab_7de9e8c98a5e
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: _AA629629_1_m
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:AA629629

metaM cit m
boundary condition: false
constant: false
is: SBO:0000247
is: C00158
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
type: Species
initial amount: NaN
is: HMDB00094
name: Citrate
initial concentration: 1.0
has only substance units: false
is: CHEBI:16947

http://identifiers.org/biomodels.db/MODEL1310110003#_95c97965_f049_4fd0_9b9e_4fbc3ff1e785
name: _AI656480_1_m
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI656480
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_95315c29_c526_4595_84b5_b6d77c991300
boundary condition: true
has part: P22392
type: Species
is encoded by: hsa:4831
initial concentration: NaN
name: NME1:NME2
initial amount: NaN
is: SBO:0000297
constant: false
has part: P15531
is encoded by: hsa:4830
has only substance units: false

metaM g3m8mpdol U r
is: C05873
has only substance units: false
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_2e1b4996_158e_4fc4_9838_0db8e8a2b4e1
name: GPX1
is: SBO:0000252
is encoded by: hsa:2876
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P07203
initial amount: NaN

metaR r1682
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
reversible: false
is described by: ECO:0000000
fast: false
modifier: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
name: Y+LAT2 Utilized transport

metaR UDPACGALtl
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
fast: false
product: MODEL1310110003#
name: udpacgal intracellular transport
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaM strdnc e
has only substance units: false
is: HMDB06547
constant: false
name: stearidonic acid C18:4, n-3
initial amount: NaN
is: C16300
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/47205608
boundary condition: false
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
type: Species

metaM man1p c
name: D-Mannose 1-phosphate
is: SBO:0000247
is: HMDB06330
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:35374
initial concentration: 1.0
type: Species

metaR r1602
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185

metaR r2323
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110003#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM CE2420 m
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28387
constant: false
has only substance units: false
is: HMDB11123
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
boundary condition: false
initial amount: NaN
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
type: Species

metaM oagd3 hs c
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
boundary condition: false
has only substance units: false
is: HMDB01514
is: CHEBI:17315
is: C00329
initial concentration: 1.0
name: 9-O-Acetylated GD3

metaM but e
constant: false
is: HMDB00039
is: CHEBI:17968
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
name: butyrate
initial amount: NaN
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: SBO:0000247

metaM gmp g
is: HMDB01397
constant: false
type: Species
name: GMP(3-)
initial amount: NaN
boundary condition: false
is: CHEBI:58115
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
initial concentration: 1.0
has only substance units: false
is: SBO:0000247

metaM dcmp n
initial concentration: 1.0
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
has only substance units: false
is: SBO:0000247
name: dCMP(2-)
constant: false
is: CHEBI:57566
type: Species
initial amount: NaN
boundary condition: false
is: HMDB01202

metaR MDHm
type: Reaction
reversible: true
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
reactant: MODEL1310110003#
fast: false
name: malate dehydrogenase, mitochondrial
is version of: http://identifiers.org/ec-code/1.1.1.37
is described by: ECO:0000134
product: MODEL1310110003#

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_77ea2303_f7ef_4688_a543_e1aa5d5124ad
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:57468
is: Q9H2X9
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
name: SLC12A5

metaR r0557
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110003#
is described by: ECO:0000000
name: Glutaryl-CoA:dihydrolipoamide S-succinyltransferase Lysine degradation EC:2.3.1.61
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:9620315 NOTES:
product: MODEL1310110003#
reversible: false
reactant: MODEL1310110003#
modifier: MODEL1310110003#

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaM dtmp c
constant: false
is: HMDB01227
is: C00364
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: dTMP
is: CHEBI:26999
boundary condition: false

metaM HC00591 c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
constant: false
name: 2-oxoglutaramate
is: SBO:0000247
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
has only substance units: false
is: CHEBI:16769

metaR DGULND
type: Reaction
reversible: true
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
name: dehydro-L-gulonate decarboxylase
is described by: ECO:0000000
product: MODEL1310110003#

metaM ca2 c
type: Species
initial amount: NaN
constant: false
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
is: CHEBI:29108
has only substance units: false
initial concentration: 1.0
name: calcium(2+)
is: SBO:0000247
is: HMDB00464
boundary condition: false

metaR UGALGTg
notes: GENE_ASSOCIATION: (3906.1) and (2683.1) or (8704.2) or (8704.1) SUBSYSTEM: Galactose metabolism EC Number: 2.4.1.22 Confidence Level: 4 AUTHORS: PMID:11419947 NOTES:NCD
name: UDPgalactose:D-glucose 4-beta-D-galactosyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110003#
reversible: false
is described by: ECO:0000134
reactant: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_9a2480d2_3b37_4921_a586_e51eb3daf5ae
name: GALNT10
is encoded by: hsa:55568
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: Q86SR1
initial amount: NaN
is: SBO:0000252
type: Species

metaR DM 4abut LPAREN n RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: PMID: 16643338 NOTES:GABA in the intestine may aid in differentiation and proliferation of epithelial cells. GABA intake by oral administration has been shown to alleviate stress, worry and anxiety and additionally it can also improve human immunity (PMID: 16971751). However the PAT1 transporter located at the apical side of enterocytes have very low affinity for GABA. I have presumed that this oral GABA is used within intestine (unless administered at high very high pharmacological doses, GABA exit from the enterocytes may be mediated by other specifc transporters).
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for 4-Aminobutanoate(n)
type: Reaction

metaR ORNt4m
kinetic law: MODEL1310110003#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
is: SBO:0000185
name: ornithine mitochondrial transport exchange with citruline
product: MODEL1310110003#
type: Reaction

metaM mi1p D n
initial concentration: 1.0
is: CHEBI:58433
name: 1D-myo-inositol 1-phosphate(2-)
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
type: Species
boundary condition: false
is: HMDB02985

metaR r0556
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
reversible: true
product: MODEL1310110003#
is: SBO:0000176
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.14.19.1
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
is described by: ECO:0000000
fast: false
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61

http://identifiers.org/biomodels.db/MODEL1310110003#_51ecd153_7326_418f_a6c8_a077a8f43ce9
constant: false
is encoded by: hsa:FLJ44968
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
name: _FLJ44968_1_m

metaR r2322
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_9728371e_60c4_4672_b6ba_3e56657b7bba
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10991
has only substance units: false
constant: false
name: SLC38A3
initial amount: NaN
is: Q99624
boundary condition: true
type: Species

metaR r1459
product: MODEL1310110003#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110003#
name: Transport reaction
type: Reaction
reactant: MODEL1310110003#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:

metaM h2o2 c
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
has only substance units: false
constant: false
initial amount: NaN
is: C00027
is: CHEBI:16240
boundary condition: false
type: Species
name: Hydrogen peroxide

metaR GLUDym
is described by: ECO:0000269
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.4.1.3
reactant: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110003#
product: MODEL1310110003#
name: glutamate dehydrogenase (NADP), mitochondrial

metaM retn c
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852
type: Species
is: CHEBI:35291
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: all-trans-retinoate

metaM HC01842 c
initial amount: NaN
is: CHEBI:31997
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
name: Phosphodimethylethanolamine

metaM sph1p c
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
initial concentration: 1.0
has only substance units: false
is: HMDB01383
is: CHEBI:57939
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120

metaR PROt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is: SBO:0000185
name: L-proline reversible transport via proton symport
reactant: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
fast: false
modifier: MODEL1310110003#
is described by: ECO:0000304

metaM aicar c
constant: false
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
initial amount: NaN
boundary condition: false
is: HMDB01517
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: C04677
type: Species
is: CHEBI:58475

metaM urcan c
has only substance units: false
is: CHEBI:17771
type: Species
name: Urocanate
initial amount: NaN
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
boundary condition: false
is: C00785
is: SBO:0000247
is: HMDB00301
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_754264fd_4a7d_4135_9b0e_d4610d010679
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: _AL038231_1_c
is encoded by: hsa:AL038231
boundary condition: true
constant: false

metaR AG13T5g
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110003#
type: Reaction
fast: false
product: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false

metaR ADSS
fast: false
modifier: MODEL1310110003#
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
reactant: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000134
name: adenylosuccinate synthase
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/6.3.4.4

metaR NAGA2ly
is version of: http://identifiers.org/ec-code/3.2.1.49
name: N-acetylgalactosaminidase, alpha-
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
kinetic law: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_6d368268_313a_461b_8350_ab7d13fb9027
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: NDUFS2
is encoded by: hsa:4720
constant: false
is: SBO:0000252
is: B7Z792
initial concentration: NaN

metaR r2537
type: Reaction
product: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
is described by: ECO:0000000
name: Utilized transport
reversible: true
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#

metaR r0224
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reversible: false
reactant: MODEL1310110003#
product: MODEL1310110003#
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
is: SBO:0000176

metaR r1019
kinetic law: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
is: SBO:0000185
name: Postulated transport reaction
type: Reaction
reactant: MODEL1310110003#
fast: false
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_a0850f3c_fff8_4049_95a0_c39c4e64a022
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is: P14672
name: SLC2A4
is encoded by: hsa:6517
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_d2edda81_7c4d_4b45_b5de_e77c44e48ae2
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q8N142
name: ADSSL1
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:122622
initial amount: NaN

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

metaR RE3005M
name: RE3005
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.107
product: MODEL1310110003#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
modifier: MODEL1310110003#

metaM asn L c
initial amount: NaN
is: CHEBI:17196
boundary condition: false
has only substance units: false
constant: false
name: L-asparagine
initial concentration: 1.0
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: HMDB00168
type: Species
is: SBO:0000247

metaR r2108
type: Reaction
product: MODEL1310110003#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110003#
is described by: ECO:0000000
fast: false
reversible: true
modifier: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_8a353742_c125_4f92_b1ef_3b6d685cf471
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is: Q5JZF5
initial concentration: NaN
is encoded by: hsa:212
name: ALAS2

metaR r1567
reactant: MODEL1310110003#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_cc1b04f3_5793_45f3_8a3e_cd54847b9ce2
initial amount: NaN
is: P28331
is encoded by: hsa:4719
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false
initial concentration: NaN
name: NDUFS1

metaR METyLATthc
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Methionine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_f183625a_fbed_44fa_bd18_a818374c1596
is encoded by: hsa:10195
initial concentration: NaN
type: Species
constant: false
name: ALG3
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM tdcoa c
type: Species
constant: false
is: C02593
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
has only substance units: false
is: CHEBI:57385
initial concentration: 1.0
initial amount: NaN
is: HMDB01521
is: SBO:0000247
boundary condition: false
name: Tetradecanoyl-CoA (n-C14:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110003#_99d1657e_467b_4761_9fb2_e9bad67fa520
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: P82251
boundary condition: true
name: SLC7A9
is: SBO:0000252
is encoded by: hsa:11136
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_51fb5eaa_a93d_443c_b5f5_73968d01fdad
type: Species
is: SBO:0000252
initial amount: NaN
name: _BC005314_1_x
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:BC005314

metaM ca2 e
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00464
is: CHEBI:29108
type: Species
name: calcium(2+)
is: SBO:0000247
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
initial concentration: 1.0
constant: false

metaM dgchol e
constant: false
has only substance units: false
type: Species
is: HMDB00637
boundary condition: false
is: CHEBI:36252
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
name: glycochenodeoxycholate
initial amount: NaN

metaR CAATPS
modifier: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
kinetic law: MODEL1310110003#
is described by: ECO:0000269
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.3.8
product: MODEL1310110003#
reversible: false
name: Ca ATPase

http://identifiers.org/biomodels.db/MODEL1310110003#_b43674c4_d792_4598_919a_22ad883cf850
is: B4DJQ3
type: Species
name: SHMT2
is encoded by: hsa:6472
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_bf4ea4be_7310_4daf_9271_61d8eac1b941
has only substance units: false
constant: false
is encoded by: hsa:7360
name: UGP2
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: Q16851

metaM 2hb c
initial amount: NaN
has only substance units: false
is: HMDB00008
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
name: 2-Hydroxybutyrate
is: CHEBI:1148
type: Species
initial concentration: 1.0

metaM ser D c
boundary condition: false
name: D-serine
initial concentration: 1.0
is: SBO:0000247
is: HMDB03406
type: Species
initial amount: NaN
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
is: CHEBI:16523
has only substance units: false
constant: false

metaM 42A3HP24DB c
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
is: HMDB04083
has only substance units: false
type: Species
is: C05645
constant: false
is: http://identifiers.org/pubchem.compound/7956
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate

metaR r0559
type: Reaction
reversible: true
fast: false
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110003#
is described by: ECO:0000000
modifier: MODEL1310110003#
product: MODEL1310110003#

metaM gluside hs g
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
name: D-glucosyl-N-acylsphingosine
is: CHEBI:18368
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM prostgi2 c
type: Species
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin I2(1-)
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
is: HMDB01335
has only substance units: false
initial amount: NaN
is: CHEBI:57403
constant: false

metaR THYOXt
kinetic law: MODEL1310110003#
reversible: true
is described by: ECO:0000269
name: T4 transport via bicarbonate countertransport
product: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_53534f1d_6713_41b0_9118_4630a58076e5
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: Q16773
is: SBO:0000252
is encoded by: hsa:883
name: CCBL1

metaM ura e
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: CHEBI:17568
is: SBO:0000247
is: HMDB00300
has only substance units: false
name: uracil
constant: false
boundary condition: false

metaM but c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: SBO:0000247
type: Species
is: CHEBI:17968
initial amount: NaN
constant: false
name: butyrate
boundary condition: false
is: HMDB00039

metaM oagd3 hs e
initial concentration: 1.0
is: HMDB02168
boundary condition: false
type: Species
name: 9-O-Acetylated GD3
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:18421
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2

metaR r0974
reactant: MODEL1310110003#
type: Reaction
reversible: true
is: SBO:0000185
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110003#
name: Active transport

http://identifiers.org/biomodels.db/MODEL1310110003#_3dd9420c_dd38_4aba_81d9_ab012c641c4b
is: SBO:0000252
is: B3KVA3
boundary condition: true
has only substance units: false
is encoded by: hsa:112724
initial concentration: NaN
name: RDH13
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_2c6f991b_72f6_433b_befe_0821f8c1e7fc
is: SBO:0000252
type: Species
is: O15244
initial amount: NaN
is encoded by: hsa:6582
has only substance units: false
boundary condition: true
name: SLC22A2
constant: false
initial concentration: NaN

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_5224c5ec_ab7a_44d2_aec1_1d91280eda3f
initial amount: NaN
is: SBO:0000252
constant: false
name: PLCXD2
type: Species
has only substance units: false
is encoded by: hsa:257068
is: Q0VAA5
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_5dd541f6_127c_409e_a584_9fc937110238
is: Q5JRA6
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
name: MIA3
is encoded by: hsa:375056

metaR r2109
product: MODEL1310110003#
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
modifier: MODEL1310110003#

metaM coa c
notes: FORMULA: C21H32N7O16P3S CHARGE: -4
type: Species
has only substance units: false
is: C00010
is: SBO:0000247
initial concentration: 1.0
is: HMDB01423
constant: false
name: Coenzyme A
initial amount: NaN
boundary condition: false
is: CHEBI:3312

metaR NACHEX27ly
fast: false
is described by: ECO:0000269
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.2.1.52
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
type: Reaction
modifier: MODEL1310110003#
reactant: MODEL1310110003#

metaR r1566
fast: false
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM dhlam m
initial concentration: 1.0
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:17694
is: HMDB00985
name: dihydrolipoamide

metaM retn e
initial concentration: 1.0
initial amount: NaN
is: HMDB01852
name: all-trans-retinoate
has only substance units: false
constant: false
is: CHEBI:35291
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: SBO:0000247
type: Species

metaR PI45PLC
reactant: MODEL1310110003#
reversible: false
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
modifier: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.4.11
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
kinetic law: MODEL1310110003#
fast: false
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_1cb9f3dd_8d74_417b_ac8d_f5f2b633c2e5
constant: false
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:8803
boundary condition: true
name: SUCLG1:SUCLA2
has part: E5KS60
has only substance units: false
type: Species
initial concentration: NaN

metaM h2o2 e
initial amount: NaN
type: Species
is: HMDB03125
is: CHEBI:16240
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: hydrogen peroxide
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false

metaR r0558
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_af55e13e_9be0_494b_bef0_848a278307b7
boundary condition: true
has only substance units: false
is: SBO:0000252
is: A6NDW6
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:79053
initial amount: NaN
name: ALG8

http://identifiers.org/biomodels.db/MODEL1310110003#_bd440940_e717_40dc_9c01_1a08e7ca15ef
boundary condition: true
name: SLC19A3
is: SBO:0000252
type: Species
has only substance units: false
is: Q9BZV2
initial amount: NaN
is encoded by: hsa:80704
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_2867382e_a4ea_4245_9f76_acdd3592470b
initial amount: NaN
has only substance units: false
is: B4DFS7
constant: false
type: Species
is encoded by: hsa:2530
boundary condition: true
name: FUT8
initial concentration: NaN
is: SBO:0000252

metaM hom L c
is: CHEBI:15699
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN
name: L-homoserine
is: HMDB00719
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_3daacace_97b3_45be_b1fa_56d67fbaa172
is encoded by: hsa:160728
is: Q8N695
name: SLC5A8
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252

metaM acnam c
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00230
boundary condition: false
is: CHEBI:35418
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
name: N-acetylneuraminate

metaR RE1233C
is described by: ECO:0000000
kinetic law: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.6.1.64
reversible: true
modifier: MODEL1310110003#
name: RE1233
fast: false

metaR S6T8g
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110003#
reversible: false
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaM HC10852 r
has only substance units: false
constant: false
is: CHEBI:61540
is: SBO:0000247
type: Species
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b10-9-/t26-,30-,31-,32+,36-/m1/s1 EHMN_ABBREVIATION: CE0852
initial concentration: 1.0
boundary condition: false
name: palmitoleyl-CoA(4-)
initial amount: NaN

metaM C05965 e
type: Species
is: CHEBI:57444
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: HMDB04243
has only substance units: false
name: 12(S)-HPETE(1-)

metaM arachdcoa x
initial concentration: 1.0
name: arachidonoyl-CoA(4-)
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: HMDB06523
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
boundary condition: false
is: SBO:0000247
is: CHEBI:57368

metaR FAS160COA
modifier: MODEL1310110003#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
reactant: MODEL1310110003#
name: fatty-acyl-CoA synthase (n-C16:0CoA)
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reversible: false
is: SBO:0000176
fast: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#

metaR GAMt1r
is: SBO:0000185
kinetic law: MODEL1310110003#
type: Reaction
reversible: true
modifier: MODEL1310110003#
is described by: ECO:0000269
fast: false
name: glucosamine transport (uniport)
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
reactant: MODEL1310110003#

metaM gdp n
boundary condition: false
is: CHEBI:58189
initial concentration: 1.0
type: Species
is: HMDB01201
name: GDP(3-)
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

metaR r1569
reactant: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110003#
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110003#
fast: false

metaM dgchol c
initial amount: NaN
has only substance units: false
constant: false
type: Species
boundary condition: false
is: HMDB00637
initial concentration: 1.0
name: glycochenodeoxycholate
is: CHEBI:36252
is: SBO:0000247
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472

metaM 2hb e
initial concentration: 1.0
boundary condition: false
is: HMDB00008
type: Species
name: 2-Hydroxybutyrate
is: SBO:0000247
constant: false
is: CHEBI:1148
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
initial amount: NaN
has only substance units: false

metaM oagd3 hs g
is: C00329
initial concentration: 1.0
constant: false
name: 9-O-Acetylated GD3
is: SBO:0000247
is: CHEBI:17315
initial amount: NaN
has only substance units: false
type: Species
is: HMDB01514
boundary condition: false
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2

metaM c226coa x
is: http://identifiers.org/pubchem.compound/47205479
type: Species
initial concentration: 1.0
name: cervonyl coenzyme A
constant: false
has only substance units: false
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: SBO:0000247
is: C16169
initial amount: NaN
boundary condition: false

metaR RE0926E
reversible: true
fast: false
product: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction
kinetic law: MODEL1310110003#
name: RE0926
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_840014d8_849a_487f_896c_cff0fef4f377
type: Species
initial amount: NaN
name: DGKG
is encoded by: hsa:1608
is: P49619
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaR PNP
name: purine-nucleoside phosphorylase
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14704851,PMID:9030766 NOTES:IT
type: Reaction
fast: false
modifier: MODEL1310110003#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110003#

metaM prostgi2 e
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01335
initial amount: NaN
boundary condition: false
name: prostaglandin I2(1-)
is: CHEBI:57403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312
constant: false
has only substance units: false

metaR r2106
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110003#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR EX ump LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UMP exchange
type: Reaction

metaM ser D e
boundary condition: false
has only substance units: false
name: D-serine
initial concentration: 1.0
is: SBO:0000247
is: HMDB03406
type: Species
initial amount: NaN
constant: false
is: CHEBI:16523
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1

metaM ura c
is: CHEBI:17568
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: SBO:0000247
initial concentration: 1.0
is: HMDB00300
is: C00106
initial amount: NaN
boundary condition: false
name: Uracil
constant: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_a3d4fb6a_9aec_46c3_af16_116a24328465
has only substance units: false
is encoded by: hsa:55967
boundary condition: true
name: NDUFA12
is: F8VQS7
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_a164411c_40aa_413f_826f_589988e73b96
name: _AU149534_1_c
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:AU149534
initial amount: NaN
has only substance units: false

metaR r2107
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110003#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110003#
is described by: ECO:0000000
modifier: MODEL1310110003#
reversible: true
product: MODEL1310110003#

metaR r0166
reactant: MODEL1310110003#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#
product: MODEL1310110003#
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
type: Reaction
is: SBO:0000176

metaR HSAT3ly
fast: false
is described by: ECO:0000000
is: SBO:0000185
reversible: false
name: heparan-glucosaminide N-acetyltransferase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#

metaM cyan m
constant: false
boundary condition: false
has only substance units: false
name: hydrogen cyanide
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
initial concentration: 1.0
is: HMDB02084
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:18407

http://identifiers.org/biomodels.db/MODEL1310110003#_369f279b_8ba6_4c9b_ba68_da639b347361
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
name: MTHFD2
constant: false
initial concentration: NaN
is encoded by: hsa:10797
is: P13995
initial amount: NaN

metaM 3pg m
is: CHEBI:58272
is: SBO:0000247
is: HMDB00807
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaM methf m
has only substance units: false
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
is: HMDB01354
is: SBO:0000247
name: (6R)-5,10-methenyltetrahydrofolate
is: CHEBI:57455
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR GTHRDt
name: Glutathione transport into mitochondria
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#
fast: false

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

metaM dcmp c
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
type: Species
is: HMDB01202
name: dCMP
is: C00239
boundary condition: false
is: CHEBI:57566

metaM gdp m
is: HMDB01201
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
initial amount: NaN
is: CHEBI:58189
constant: false
is: C00035
initial concentration: 1.0
name: GDP

metaR r1568
product: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110003#
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_fd2c448c_001c_46ac_b9c0_6611f9ac7ccc
is: Q9UNU6
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:1582
initial concentration: NaN
has only substance units: false
name: CYP8B1
is: SBO:0000252

metaM triodthy e
is: CHEBI:18258
name: 3,3',5-triiodo-L-thyronine
is: HMDB00265
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
initial amount: NaN
is: SBO:0000247

metaM tyr L e
has only substance units: false
is: CHEBI:17895
name: L-tyrosine
is: SBO:0000247
constant: false
is: HMDB00158
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085

http://identifiers.org/biomodels.db/MODEL1310110003#_5d1be64b_2ebb_47b9_89c7_679946d7c5ff
constant: false
is: P51687
initial amount: NaN
is encoded by: hsa:6821
has only substance units: false
type: Species
name: SUOX
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM bildglcur c
constant: false
initial amount: NaN
type: Species
is: HMDB03325
has only substance units: false
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin
initial concentration: 1.0
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
boundary condition: false
is: CHEBI:58471

metaM hom L e
constant: false
initial concentration: 1.0
initial amount: NaN
name: L-homoserine
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: SBO:0000247
boundary condition: false
is: CHEBI:15699
is: HMDB00719
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_5ab2c9c3_ec51_49cc_b515_b0979dd95fd1
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: P21399
is encoded by: hsa:48
name: ACO1

http://identifiers.org/biomodels.db/MODEL1310110003#_4513fb83_1adc_4c23_963e_e09473c01554
initial concentration: NaN
is encoded by: hsa:7372
is: SBO:0000252
name: UMPS
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: A8K5J1
has only substance units: false

metaR DUDPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110003#
is: SBO:0000185
reversible: true
name: dUDP nuclear transport

http://identifiers.org/biomodels.db/MODEL1310110003#_9a7967dc_fac7_4a07_9e46_8103401f5235
is: SBO:0000252
type: Species
is: Q9H6Y6
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:4645
name: MYO5B

metaM lcts e
is: CHEBI:17716
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
boundary condition: false
type: Species
constant: false
name: Lactose
is: C00243
initial amount: NaN
has only substance units: false
is: HMDB00186
initial concentration: 1.0
is: SBO:0000247

metaR r1010
is described by: ECO:0000000
name: Postulated transport reaction
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110003#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#

metaM acngalgbside hs g
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:16523
is: HMDB03406
is: SBO:0000247
initial concentration: 1.0
name: sialyl galactosylgloboside
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1

metaR r2104
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110003#
modifier: MODEL1310110003#

metaM dtmp m
constant: false
is: HMDB01227
is: SBO:0000247
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial concentration: 1.0
name: dTMP
is: CHEBI:26999
type: Species
boundary condition: false
is: C00364
initial amount: NaN
has only substance units: false

metaM ksi pre17 g
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 17
is: CHEBI:28067
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C157H252N11O127S5X CHARGE: -6

metaM dlnlcgcoa c
name: dihomo-gamma-linolenyl coenzyme A
is: CHEBI:27979
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
has only substance units: false
initial amount: NaN
type: Species

metaM gluside hs c
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:18368
type: Species
name: D-glucosyl-N-acylsphingosine

metaR HISCAT1
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaR S6T1g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
fast: false
product: MODEL1310110003#
is described by: ECO:0000000
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reversible: false
is: SBO:0000176

metaM dheas e
is: CHEBI:57905
initial amount: NaN
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
is: HMDB01032
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555

http://identifiers.org/biomodels.db/MODEL1310110003#_84dcd420_e7fe_48db_b500_c06bd447919a
constant: false
is: P23786
name: CPT2
is encoded by: hsa:1376
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252

metaR r0679
fast: false
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.16
reactant: MODEL1310110003#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
product: MODEL1310110003#

metaR r2105
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110003#
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR r2053
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
modifier: MODEL1310110003#
fast: false
type: Reaction
reactant: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR r0339
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.2.22
type: Reaction
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is: SBO:0000176
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.2.2
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110003#
fast: false
reversible: false

metaR HEX7
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
is described by: ECO:0000304
name: hexokinase (D-fructose:ATP)
is version of: http://identifiers.org/ec-code/2.7.1.1
is: SBO:0000176
reversible: false
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.1.2
type: Reaction
fast: false
reactant: MODEL1310110003#

metaM dudp c
initial concentration: 1.0
is: CHEBI:60471
is: HMDB01000
is: SBO:0000247
is: C01346
constant: false
name: dUDP
type: Species
boundary condition: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial amount: NaN
has only substance units: false

metaM mthgxl c
initial concentration: 1.0
is: HMDB01167
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
name: methylglyoxal
is: CHEBI:17158
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_12a7bbc6_8f0f_47a5_a96a_10d682ad4065
is: P47895
is encoded by: hsa:220
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: ALDH1A3
type: Species
has only substance units: false
initial concentration: NaN

metaM coa g
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: coenzyme A(4-)
is: HMDB01423
is: CHEBI:57287
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaM homoval m
initial concentration: 1.0
boundary condition: false
is: HMDB00118
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:545959
name: Homovanillate
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
is: SBO:0000247

metaM h2o2 m
boundary condition: false
is: CHEBI:16240
is: HMDB03125
initial amount: NaN
constant: false
is: SBO:0000247
is: C00027
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
name: Hydrogen peroxide
has only substance units: false
type: Species

metaM tyr L c
name: L-tyrosine
is: CHEBI:17895
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00158
boundary condition: false
type: Species
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_c30994c8_d1f8_4f47_b95f_ddd15c0a2490
has only substance units: false
initial amount: NaN
is encoded by: hsa:4247
name: MGAT2
initial concentration: NaN
is: Q10469
constant: false
type: Species
boundary condition: true
is: SBO:0000252

metaR G14T4g
kinetic law: MODEL1310110003#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110003#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176

metaR LDH D
is: SBO:0000176
kinetic law: MODEL1310110003#
name: D-lactate dehydrogenase
reactant: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/1.1.2.4
reversible: true
type: Reaction
is described by: ECO:0000304
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
product: MODEL1310110003#

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_2c14316f_897f_4578_8392_db9f6f5d2655
type: Species
constant: false
initial amount: NaN
is: P08195
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: SLC3A2
has only substance units: false
is encoded by: hsa:6520

metaR r2102
modifier: MODEL1310110003#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#

metaM tym c
is: SBO:0000247
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
constant: false
boundary condition: false
initial amount: NaN
name: tyraminium
type: Species
initial concentration: 1.0
is: HMDB00306
has only substance units: false
is: CHEBI:327995

metaM n2m2nmasn l
boundary condition: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C58H96N5O40X CHARGE: 0
type: Species
initial concentration: 1.0
constant: false
is: C04946
has only substance units: false

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

metaR RE1516M
fast: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
modifier: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: RE1516
is version of: http://identifiers.org/ec-code/1.3.99.13
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_ad76fff1_a04b_4bc0_902d_ad88e8b2df0a
constant: false
is: G3V4L5
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:89874
name: SLC25A21

metaR G14T17g
is: SBO:0000176
fast: false
reversible: false
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaM lcts g
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-3-5(15)6(16)9(19)12(22-3)23-10-4(2-14)21-11(20)8(18)7(10)17/h3-20H,1-2H2/t3-,4-,5+,6+,7-,8-,9-,10-,11?,12+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00220 EHMN_ABBREVIATION: C00243
is: SBO:0000247
name: lactose
is: HMDB00186
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:17716

http://identifiers.org/biomodels.db/MODEL1310110003#_78be77d2_9d04_44eb_9035_fc4ba5abaf0c
constant: false
type: Species
boundary condition: true
is: P54819
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: AK2
is encoded by: hsa:204

metaM 6dhf e
is: SBO:0000247
is: HMDB06563
constant: false
initial concentration: 1.0
name: hexaglutamyl folate (DHF)
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
boundary condition: false
has only substance units: false
initial amount: NaN
type: Species

metaR PIt7
modifier: MODEL1310110003#
is: SBO:0000185
name: phosphate transport in/out via three Na+ symporter
fast: false
reactant: MODEL1310110003#
is described by: ECO:0000269
kinetic law: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT

metaR HEX4
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
fast: false
product: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.2
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.1.1
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: false
name: hexokinase (D-mannose:ATP)

metaR RE3627M
type: Reaction
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
name: RE3627
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110003#
is: SBO:0000176
reversible: true

metaR GLYtp
fast: false
type: Reaction
kinetic law: MODEL1310110003#
reversible: true
is described by: ECO:0000000
name: glycine passive transport to peroxisome
is: SBO:0000185
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV

metaM nm2masn g
type: Species
notes: FORMULA: C42H70N3O30X CHARGE: 0
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
initial concentration: 1.0
is: C05884
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_9fcdf0c0_566b_4d69_b143_2052c1ca9e8d
name: SLC35D2
type: Species
initial concentration: NaN
initial amount: NaN
is: Q76EJ3
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:11046

metaR ADSK
is version of: http://identifiers.org/ec-code/2.7.1.25
reactant: MODEL1310110003#
is described by: ECO:0000269
fast: false
type: Reaction
kinetic law: MODEL1310110003#
name: adenylyl-sulfate kinase
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
product: MODEL1310110003#
modifier: MODEL1310110003#

metaM coa e
is: CHEBI:57287
boundary condition: false
has only substance units: false
is: HMDB01423
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
name: Coenzyme A
is: C00010
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

http://identifiers.org/biomodels.db/MODEL1310110003#_b26099fc_99e9_4e0f_8748_a2530ea56ab8
is encoded by: hsa:9058
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: E7ETH5
initial amount: NaN
name: SLC13A2
boundary condition: true

metaR r0443
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000176
reversible: false
product: MODEL1310110003#
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.42
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21

metaM dheas c
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
type: Species
is: CHEBI:57905
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
is: HMDB01032

http://identifiers.org/biomodels.db/MODEL1310110003#_8055a326_de0a_42e4_ae84_8660d2d336bb
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: NDUFS6
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:4726
constant: false
is: Q6IBC4

http://identifiers.org/biomodels.db/MODEL1310110003#_05a052a2_a4be_447b_8a78_661d06ec5b8a
is encoded by: hsa:10317
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
name: B3GALT5
constant: false
has only substance units: false

metaR HISD
is: SBO:0000176
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
product: MODEL1310110003#
is described by: ECO:0000269
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.3.1.3
modifier: MODEL1310110003#
reversible: false
name: histidase
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_a250d792_bf79_4a9f_8e3e_e9d4918d06a3
has only substance units: false
initial amount: NaN
is: Q92959
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6578
constant: false
type: Species
is: SBO:0000252
name: SLCO2A1

metaR r0973
fast: false
name: Facilitated diffusion
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is: SBO:0000185
product: MODEL1310110003#

metaM f6p c
name: D-Fructose 6-phosphate
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:57579
constant: false
is: C00085
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3385
is: HMDB00124

metaR PEAMNO
is version of: http://identifiers.org/ec-code/1.4.3.22
modifier: MODEL1310110003#
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.4
is: SBO:0000176
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.4.3.21
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
name: Phenethylamine oxidase
kinetic law: MODEL1310110003#

metaR r2103
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: true
is: SBO:0000185
reactant: MODEL1310110003#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_a32618fd_efd1_4a4f_97c6_17b09b4b99d1
initial amount: NaN
has only substance units: false
name: _AA532636_1_m
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:AA532636
boundary condition: true
initial concentration: NaN

metaR DURItn
is described by: ECO:0000000
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110003#
name: deoxyuridine transport in nucleus
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaM mthgxl e
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
constant: false
is: CHEBI:17158
boundary condition: false
name: methylglyoxal
initial amount: NaN
type: Species
is: HMDB01167

metaR EX Rtotal3 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 3 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_13cf5f89_1e87_4f02_8a61_00587857db01
is: SBO:0000252
is encoded by: hsa:5313
type: Species
has only substance units: false
is: P30613
initial amount: NaN
initial concentration: NaN
name: PKLR
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_016c898f_75f6_4cf5_8739_a3a973c08166
is: P21108
constant: false
initial amount: NaN
is encoded by: hsa:221823
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: PRPS1L1

metaR RE1522M
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
fast: false
name: RE1522
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110003#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_a202e5bc_bb66_42cb_8b40_73a03f722a87
boundary condition: true
constant: false
name: SDS
type: Species
is encoded by: hsa:10993
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P20132
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_5da14927_c093_4a23_ad77_67f91a04e61e
has only substance units: false
name: ACSS2
initial concentration: NaN
is encoded by: hsa:55902
initial amount: NaN
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: Q5QPH3

http://identifiers.org/biomodels.db/MODEL1310110003#_a2dbb9cf_7a03_4e08_a67a_056af019a582
initial amount: NaN
boundary condition: true
name: NMRK1
constant: false
is: SBO:0000252
is encoded by: hsa:54981
has only substance units: false
is: Q9NWW6
type: Species
initial concentration: NaN

metaR PIt8
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
product: MODEL1310110003#
name: phosphate transport in/out via Na+ symporter
kinetic law: MODEL1310110003#
reversible: true
is described by: ECO:0000006
fast: false
type: Reaction
modifier: MODEL1310110003#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_05dabddd_0afc_4d5c_8d97_7afb55135d60
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is: P14618
name: PKM2
is encoded by: hsa:5315
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_bc4a0945_7286_410d_96f1_872af3a00746
boundary condition: true
type: Species
is encoded by: hsa:9377
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P20674
initial amount: NaN
name: COX5A

metaM CE5119 m
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
is: HMDB00127
is: SBO:0000247
type: Species
initial amount: NaN
name: trans-3-cis-8-tetradecadienoyl-CoA
is: CHEBI:15748

http://identifiers.org/biomodels.db/MODEL1310110003#_aa04251e_bd2b_45cb_bfa7_4a5af02f124f
name: SLC2A2
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:6514
is: SBO:0000252
is: P11168
initial amount: NaN
constant: false

metaM n2m2nmasn e
initial amount: NaN
is: SBO:0000247
type: Species
is: C04946
boundary condition: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
constant: false
initial concentration: 1.0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
has only substance units: false

metaM odecoa m
name: Octadecenoyl-CoA (n-C18:1CoA)
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
is: CHEBI:57387
boundary condition: false
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01322
initial concentration: 1.0
is: SBO:0000247

metaM h2o2 n
is: SBO:0000247
name: hydrogen peroxide
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB03125
is: CHEBI:16240
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial amount: NaN
constant: false

metaR RE3628M
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3628
modifier: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/5.3.3.8
product: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is described by: ECO:0000000
type: Reaction
reversible: true

metaR HDCEAtr
type: Reaction
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110003#
product: MODEL1310110003#
name: fatty acid transport via diffusion

metaM 3m4hpga c
is: SBO:0000247
has only substance units: false
is: C05583
is: HMDB04061
notes: FORMULA: C9H10O4 CHARGE: 0 INCHI: InChI=1/C9H10O4/c1-13-9-4-6(8(12)5-10)2-3-7(9)11/h2-5,8,11-12H,1H3 HEPATONET_1.0_ABBREVIATION: HC01520 EHMN_ABBREVIATION: C05583
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7909
constant: false

metaM g1m8mpdol U r
is: SBO:0000247
is: CHEBI:59093
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
type: Species
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
initial concentration: 1.0

metaM 3pg c
initial amount: NaN
constant: false
is: SBO:0000247
is: C00197
is: HMDB00807
is: http://identifiers.org/pubchem.compound/3497
initial concentration: 1.0
name: 3-Phospho-D-glycerate
has only substance units: false
boundary condition: false
is: CHEBI:58272
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_92638527_2c9a_41a7_b93c_fcb3fac7aeb0
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: P00558
name: PGK1
is encoded by: hsa:5230
is: SBO:0000252

metaR r0817
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
fast: false
reversible: true
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
is: SBO:0000185
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
is described by: ECO:0000000

metaR RE0512M
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE0512
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
reactant: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
kinetic law: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_d9552f56_d0b3_4b81_8985_08bd22aaa0f1
constant: false
name: SLC5A5
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:6528
initial concentration: NaN
initial amount: NaN
is: Q92911

metaM CE2424 m
initial amount: NaN
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
type: Species
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB11123
boundary condition: false
is: CHEBI:28387
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_3677bc8e_d34c_42e5_9bdf_db5f40eae481
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:768
name: CA9
is: Q16790
type: Species
constant: false

metaR SO4t4 2
fast: false
modifier: MODEL1310110003#
is: SBO:0000185
reversible: true
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
name: sulfate transport via sodium symport
type: Reaction
reactant: MODEL1310110003#

metaM hs deg4 l
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: heparan sulfate, degradation product 4
is: CHEBI:16126
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_5b0880ad_1b21_4440_9732_46cc37bde35f
constant: false
type: Species
is encoded by: hsa:4124
name: MAN2A1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: Q16706

metaM gtp c
initial concentration: 1.0
initial amount: NaN
constant: false
is: C00044
name: GTP
has only substance units: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
type: Species
is: SBO:0000247
is: HMDB01273
is: CHEBI:37565
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_175527ec_4cda_4c3e_8ceb_9539c5c48e1f
is: P08195
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6520
name: SLC3A2
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM C02528 r
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
is: HMDB00518
name: chenodeoxycholate
type: Species
is: CHEBI:36234
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247

metaM mi1p D c
is: CHEBI:58433
type: Species
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
boundary condition: false
has only substance units: false
is: HMDB02985
name: 1D-myo-inositol 1-phosphate(2-)
constant: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_43922ad5_bb8d_4c05_87fa_76e3609e9145
initial amount: NaN
constant: false
is: O00767
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6319
boundary condition: true
initial concentration: NaN
name: SCD

http://identifiers.org/biomodels.db/MODEL1310110003#_78cc9c5e_fd2d_440b_8f6a_3fd348837823
is encoded by: hsa:53354
initial amount: NaN
name: PANK1
is: SBO:0000252
has only substance units: false
is: Q8TE04
boundary condition: true
initial concentration: NaN
constant: false
type: Species

metaR DOLDPP Uer
reversible: false
type: Reaction
product: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD
kinetic law: MODEL1310110003#
fast: false
is described by: ECO:0000000
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
is version of: http://identifiers.org/ec-code/3.6.1.43

metaR 34HPPte
fast: false
reversible: true
type: Reaction
is described by: ECO:0000134
is: SBO:0000185
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
name: Transport of 3-(4-hydroxyphenyl)pyruvate
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM gudac c
initial amount: NaN
constant: false
notes: FORMULA: C3H7N3O2 CHARGE: 0 INCHI: InChI=1S/C3H7N3O2/c4-3(5)6-1-2(7)8/h1H2,(H,7,8)(H4,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00439 EHMN_ABBREVIATION: C00581
is: HMDB00128
boundary condition: false
has only substance units: false
is: CHEBI:16344
type: Species
initial concentration: 1.0
is: SBO:0000247
name: guanidinoacetic acid

http://identifiers.org/biomodels.db/MODEL1310110003#_894d67af_a72e_415a_b3b2_0f0812265b5d
is encoded by: hsa:53919
initial concentration: NaN
has only substance units: false
name: SLCO1C1
initial amount: NaN
is: Q5JPA4
boundary condition: true
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_d3555b51_51f7_4907_9340_aba3881753b8
constant: false
has only substance units: false
is: SBO:0000252
name: ALDH3B1
initial concentration: NaN
type: Species
is encoded by: hsa:221
is: P43353
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_4d397844_5be7_4909_8a59_b58842dcb495
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P53597
name: SUCLG1
has only substance units: false
type: Species
is encoded by: hsa:8802
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_ac1257ec_6c25_47c6_a607_0d24457cbb38
name: HIBCH
type: Species
has only substance units: false
constant: false
boundary condition: true
is: Q6NVY1
is: SBO:0000252
is encoded by: hsa:26275
initial concentration: NaN
initial amount: NaN

metaR AG13T13g
is: SBO:0000176
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaM lnlncg r
initial concentration: 1.0
name: gamma-linolenate
has only substance units: false
constant: false
is: CHEBI:32391
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: SBO:0000247
boundary condition: false
is: HMDB03073
initial amount: NaN
type: Species

metaR EX mthgxl LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Methylglyoxal exchange
type: Reaction

metaR r1560
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
fast: false
reversible: true

metaM pa hs r
is: CHEBI:57739
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
constant: false
initial amount: NaN
name: phosphatidate(2-)
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416

http://identifiers.org/biomodels.db/MODEL1310110003#_47076511_2c00_430b_94ab_7f71b994b199
is encoded by: hsa:8867
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is: O43426
has only substance units: false
constant: false
name: SYNJ1

metaR r0819
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
modifier: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_4942097a_8edd_410f_8b51_63757289c74b
has only substance units: false
constant: false
is encoded by: hsa:AV717590
name: _AV717590_1_c
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM ksi pre9 g
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00175
is: CHEBI:58053
initial concentration: 1.0
constant: false
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
type: Species
is: C00130
name: keratan sulfate I biosynthesis, precursor 9
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_8d00adb2_2715_42e3_887c_0a46177859d9
boundary condition: true
constant: false
is encoded by: hsa:10201
has only substance units: false
initial concentration: NaN
name: NME6
initial amount: NaN
is: O75414
type: Species
is: SBO:0000252

metaM mi1345p c
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:57895
has only substance units: false
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
initial amount: NaN
initial concentration: 1.0
type: Species
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
is: HMDB01059

metaR r1707
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
reversible: false
modifier: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
name: Y+LAT2 Utilized transport
fast: false

metaR MANt4
name: D-mannose transport via sodium cotransport
kinetic law: MODEL1310110003#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is: SBO:0000185
reversible: true
reactant: MODEL1310110003#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_5ae6ba68_611c_4887_8275_6326269ebe80
has only substance units: false
is: E7EPT3
initial amount: NaN
boundary condition: true
type: Species
name: ALDH7A1
is: SBO:0000252
is encoded by: hsa:501
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_c1821514_d6e2_4cca_9434_3931698c03e2
is: Q9HC21
initial amount: NaN
name: SLC25A19
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:60386

metaM bildglcur e
is: CHEBI:58471
boundary condition: false
has only substance units: false
name: bis(beta-glucosyluronate)bilirubin
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB03325
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787

http://identifiers.org/biomodels.db/MODEL1310110003#_ddead30f_091b_4e41_944f_8e6bb94c576b
initial concentration: NaN
is: SBO:0000252
is: Q6IB80
name: NDUFB3
is encoded by: hsa:4709
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaR r1561
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_e17d57db_bae2_421c_94e7_14372287c8d5
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:89869
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: Q86YW0
name: PLCZ1

metaM ksi pre6 g
type: Species
boundary condition: false
is: C00130
name: keratan sulfate I biosynthesis, precursor 6
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C107H174N7O80SX CHARGE: -2
is: CHEBI:58053
is: HMDB00175

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaR DGNSKm
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.113
product: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
modifier: MODEL1310110003#
reversible: false
fast: false
is: SBO:0000176
name: deoxyguanosine kinase

http://identifiers.org/biomodels.db/MODEL1310110003#_33e3fede_2728_451c_b1c0_6cfa912ed9dd
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: ALDH4A1
type: Species
is encoded by: hsa:8659
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_990fea87_694a_442b_afe0_a4da73b9a28b
constant: false
is encoded by: hsa:7371
is: SBO:0000252
is: Q9BZX2
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: UCK2
initial amount: NaN

metaM hs deg7 l
constant: false
type: Species
has only substance units: false
name: heparan sulfate, degradation product 7
initial concentration: 1.0
notes: FORMULA: C67H99N4O80S8 CHARGE: -9
is: SBO:0000247
initial amount: NaN
is: CHEBI:15699
is: HMDB00719
boundary condition: false

metaM gd3 hs g
has only substance units: false
name: GD3
is: CHEBI:28424
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR PRISTCOAtx
fast: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
reversible: true
name: pristcoa peroxisomal transport
kinetic law: MODEL1310110003#
type: Reaction

metaR r1562
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false
reversible: true

metaM Rtotal2 c
is: SBO:0000247
has only substance units: false
name: R total 2 position
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: HMDB00095
is: C00055
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
is: CHEBI:60377

metaR NH4t3r
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
modifier: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
name: ammonia transport via proton antiport
is: SBO:0000185

metaM kynate c
constant: false
is: HMDB00715
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
name: kynurenate
has only substance units: false
boundary condition: false
is: CHEBI:58454

metaR PROSTGD2t
type: Reaction
modifier: MODEL1310110003#
fast: false
is described by: ECO:0000269
product: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
reversible: true
name: prostaglandin transport via bicarbonate countertransport
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ

metaR r0753
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
reversible: true
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_5bd567d3_7708_4dc2_b1f0_e2c3665e1de4
is: SBO:0000252
constant: false
type: Species
name: LDHC
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3948

http://identifiers.org/biomodels.db/MODEL1310110003#_a691d1b1_6c61_45ce_a010_3a69d38f57fb
is: P49915
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8833
boundary condition: true
has only substance units: false
name: GMPS
initial concentration: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_11634b5f_a357_4321_a288_c867383f66cd
is: SBO:0000252
is: O43175
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:26227
name: PHGDH

metaM retn r
initial concentration: 1.0
has only substance units: false
is: CHEBI:35291
is: HMDB01852
initial amount: NaN
is: SBO:0000247
constant: false
name: all-trans-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
boundary condition: false
type: Species

metaR r0062
product: MODEL1310110003#
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.1 Confidence Level: 0 AUTHORS: PMID:11322891,PMID:12545200,PMID:16951743,PMID:34392,PMID:6151837,PMID:7696329 NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.1.17
reactant: MODEL1310110003#
reversible: false
name: Acetyl-CoA hydrolase Pyruvate metabolism EC:3.1.2.1
fast: false

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_07c11767_6924_4184_be28_fb7ff30a52d1
boundary condition: true
name: SGPL1
type: Species
initial amount: NaN
has only substance units: false
is: O95470
initial concentration: NaN
is encoded by: hsa:8879
constant: false
is: SBO:0000252

metaR HSD3A1r
kinetic law: MODEL1310110003#
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
modifier: MODEL1310110003#
reversible: true
type: Reaction
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.225
is described by: ECO:0000269
reactant: MODEL1310110003#

metaM ksi pre28 g
boundary condition: false
is: C00130
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00175
constant: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 28
initial concentration: 1.0
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
is: CHEBI:58053

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_ab9ce4c2_865e_423c_a77d_b1c61c93f59f
boundary condition: true
is: B3KU59
initial amount: NaN
is encoded by: hsa:6547
constant: false
type: Species
has only substance units: false
name: SLC8A3
is: SBO:0000252
initial concentration: NaN

metaM dcholcoa c
boundary condition: false
initial amount: NaN
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
has only substance units: false
initial concentration: 1.0
name: chenodeoxycholoyl coenzyme a
is: SBO:0000247
is: HMDB06292
type: Species
constant: false
is: CHEBI:28701

metaR LEUKTRD4t
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
is described by: ECO:0000269
name: leukotriene D4 transport
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction

metaM m7masnB r
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C64H107N2O50X CHARGE: 0
has only substance units: false
is: C05881
constant: false

metaR r1563
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_7725074a_53a9_41f5_915e_95088c24335e
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
name: NDUFA9
is: Q16795
is encoded by: hsa:4704
constant: false
has only substance units: false

metaM 4hoxpacd c
name: (4-hydroxyphenyl)acetaldehyde
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
is: HMDB03767
constant: false
has only substance units: false
type: Species
is: CHEBI:15621
boundary condition: false

metaR r0752
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
reversible: true
product: MODEL1310110003#
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is: SBO:0000176
type: Reaction

metaR r0330
reversible: false
modifier: MODEL1310110003#
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is described by: ECO:0000000
reactant: MODEL1310110003#
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:

metaM ach c
is: HMDB00895
boundary condition: false
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
name: acetylcholine
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_e7c797e0_aa55_4638_87d5_2b69f05c5bdc
is: SBO:0000252
name: MCEE
has only substance units: false
is encoded by: hsa:84693
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: Q96PE7
boundary condition: true

metaR r0755
is described by: ECO:0000000
product: MODEL1310110003#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (37.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:1898068 NOTES:
fast: false
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_155c3eb5_dde9_4059_a7f0_35d5bf9fae3f
constant: false
has part: P04843
has part: P04844
boundary condition: true
type: Species
is encoded by: hsa:6185
is encoded by: hsa:6184
is encoded by: hsa:1650
initial amount: NaN
name: DAD1:DDOST:RPN1:RPN2
has part: P39656
is: SBO:0000297
has part: Q53G02
initial concentration: NaN
is encoded by: hsa:1603
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_5893ea0c_bbf0_4cc3_b2e0_fc5452773d56
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6470
constant: false
name: SHMT1

metaR r0899
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
reversible: true
product: MODEL1310110003#
is: SBO:0000185
fast: false
name: Amino acid transporter ATB0+ Facilitated diffusion
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_dc1958f5_0143_4729_8633_7125e5f94cd5
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: _R06874_1_r
boundary condition: true
is encoded by: hsa:R06874
type: Species

metaM coa m
has only substance units: false
name: Coenzyme A
is: CHEBI:57287
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
is: C00010
constant: false

metaR r1117
type: Reaction
reversible: true
name: Facilitated diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
reactant: MODEL1310110003#
fast: false
product: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#

metaR DM T antigen g
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaM cl c
has only substance units: false
is: HMDB00492
type: Species
constant: false
name: Chloride
is: SBO:0000247
initial concentration: 1.0
is: C00115
boundary condition: false
notes: FORMULA: Cl CHARGE: -1
initial amount: NaN
is: CHEBI:3966

metaR r1564
is described by: ECO:0000000
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR O2St
is: SBO:0000185
reversible: true
name: superoxide anion transport via diffusion (extracellular)
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reactant: MODEL1310110003#
type: Reaction

metaM Rtotal2 e
notes: FORMULA: CO2FULLR2 CHARGE: -1
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
is: C00255
name: R total 2 position
is: HMDB00244
is: CHEBI:3554
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_e6c18234_0c8c_4b3f_887e_c58af71c5a56
constant: false
initial amount: NaN
type: Species
is: Q8N3T1
is encoded by: hsa:117248
has only substance units: false
initial concentration: NaN
name: GALNTL2
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_3b9cc30d_d7ef_4a22_be5e_fa8f5814429a
initial concentration: NaN
is encoded by: hsa:248
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
constant: false
name: ALPI
is: P09923

metaR H2O2syn
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: false
type: Reaction
product: MODEL1310110003#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.6.3.1
fast: false
modifier: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (53905.1) or (50506.1) or (53905.2) SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15677770,PMID:15972824 NOTES:SAB lumped reaction--first O2 goes to superoxide radical, then dismutes to H2O2
name: Hydrogen peroxide synthesis (NADPH dependent)

metaR r0754
modifier: MODEL1310110003#
fast: false
name: 3-Methoxy-4-hydroxyphenylacetaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110003#
reversible: true
is: SBO:0000176
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_47e3f2fb_613c_4c92_bb8e_b21588e8dc7b
initial amount: NaN
constant: false
boundary condition: true
is: Q7GXZ4
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4539
has only substance units: false
type: Species
name: ND4L

metaR CYTK6n
type: Reaction
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110003#
name: cytidylate kinase (CMP,CTP),nuclear
fast: false
is: SBO:0000176

metaM paf hs e
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
type: Species
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:36707
initial amount: NaN
has only substance units: false

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR LYStip
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
type: Reaction
name: L-lysine transport, peroxisomal (irreversible)
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaM coa n
is: HMDB01423
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:57287
boundary condition: false
name: coenzyme A(4-)
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010

metaR DHAAt1r
fast: false
type: Reaction
name: dehydroascorbate transport (uniport)
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110003#
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
reactant: MODEL1310110003#
reversible: true

metaR EX pi LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphate exchange
type: Reaction

metaR r1565
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#

metaR r1116
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
type: Reaction
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR LEUPHELAT2tc
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM ach e
has only substance units: false
boundary condition: false
is: CHEBI:15355
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
name: acetylcholine
is: HMDB00895
initial concentration: 1.0

metaR RE2079R
kinetic law: MODEL1310110003#
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: true
product: MODEL1310110003#
name: RE2079
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
type: Reaction
reactant: MODEL1310110003#

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaM 7dhchsterol r
has only substance units: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
is: CHEBI:17759
name: cholesta-5,7-dien-3beta-ol
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: HMDB00032

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_79d04831_fbf8_4e13_8210_82ac54d88b84
is: P27707
has only substance units: false
initial amount: NaN
name: DCK
type: Species
is: SBO:0000252
is encoded by: hsa:1633
constant: false
initial concentration: NaN
boundary condition: true

metaR XYLUR
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
is described by: ECO:0000269
fast: false
product: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
name: xylulose reductase
kinetic law: MODEL1310110003#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.10

metaM lnlncg l
boundary condition: false
has only substance units: false
is: HMDB03073
initial concentration: 1.0
is: SBO:0000247
type: Species
name: gamma-linolenate
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
is: CHEBI:32391
initial amount: NaN
constant: false

metaR r1453
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_5949fe8e_3203_462d_a484_6f6ff2b24db9
has only substance units: false
is: B7Z5T8
initial concentration: NaN
name: CPT1B
initial amount: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:1375
is: SBO:0000252

metaM lnlccoa r
boundary condition: false
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5462164
name: linoleic coenzyme A
is: HMDB01064
initial amount: NaN
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_b215d9ff_37a5_42ac_8b7c_90af7d10c386
type: Species
is encoded by: hsa:8801
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
name: SUCLG2
is: Q96I99
constant: false

metaR MALSO4tm
name: Malate:sulfate antiport, mitochondrial
reversible: true
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
type: Reaction
is: SBO:0000185
is described by: ECO:0000269

metaR CITtam
kinetic law: MODEL1310110003#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
name: citrate transport, mitochondrial
type: Reaction
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000185
product: MODEL1310110003#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110003#_c34e5718_fc8c_4528_baa6_b32646089b9c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
type: Species
is encoded by: hsa:1607
boundary condition: true
name: DGKB

http://identifiers.org/biomodels.db/MODEL1310110003#_8ee6373f_e62e_47d8_9d96_f6569b781d71
has only substance units: false
name: NDUFV2
is encoded by: hsa:4729
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P19404
is: SBO:0000252
type: Species

metaR MGSA
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
name: methylglyoxal synthase
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_42e74e5a_8288_40bf_9204_f44c675374a7
initial amount: NaN
is encoded by: hsa:8776
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
name: MTMR1
has only substance units: false
is: Q13613
type: Species

metaM 5adtststerones c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
is: HMDB06278
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
name: 5alpha-Dihydrotestosterone sulfate

metaM pail5p hs n
type: Species
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial concentration: 1.0
is: CHEBI:57795
boundary condition: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_71ada82a_e48d_4a22_8b38_2f53a35c1e23
name: SDHB
is: SBO:0000252
is encoded by: hsa:6390
has only substance units: false
initial concentration: NaN
constant: false
is: P21912
type: Species
initial amount: NaN
boundary condition: true

metaR RBTt
product: MODEL1310110003#
is: SBO:0000185
reversible: false
name: ribitol transport via passive diffusion
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reactant: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#

metaR NDPK5n
fast: false
is described by: ECO:0000304
reversible: true
is: SBO:0000176
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
product: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_7f512675_4983_45bb_872b_2e03bc823d75
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:57835
name: SLC4A5
initial amount: NaN

metaM peamn c
is: HMDB12275
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
is: CHEBI:225237
name: 2-phenylethanaminium
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_57229e9e_3ab3_49a2_8d58_d306ed288840
is encoded by: hsa:9481
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
is: F5GWR4
constant: false
type: Species
initial amount: NaN
name: SLC25A27

metaR TSULt4 3
name: thiosulfate transport via sodium symport
product: MODEL1310110003#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
reversible: true
is described by: ECO:0000269

metaM dudp m
is: HMDB01000
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:60471
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
name: dUDP(3-)
has only substance units: false
is: SBO:0000247

metaR r1455
is described by: ECO:0000000
type: Reaction
name: Transport reaction
product: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reversible: false
kinetic law: MODEL1310110003#

metaR M4MPDOL Uter
fast: false
type: Reaction
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
name: m4mpdol flippase
reversible: false
is: SBO:0000185

metaM HC02180 e
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:28728
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial amount: NaN
name: thromboxane-b2

http://identifiers.org/biomodels.db/MODEL1310110003#_c55d98f8_cd92_4a94_b1c5_fa8fb3d9a10b
type: Species
boundary condition: true
is: Q9H0N5
constant: false
is encoded by: hsa:84105
is: SBO:0000252
has only substance units: false
name: PCBD2
initial concentration: NaN
initial amount: NaN

metaM n2m2masn g
is: C11530
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C50H83N4O35X CHARGE: 0
initial concentration: 1.0
constant: false
has only substance units: false
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
type: Species
boundary condition: false

metaR CYTK12n
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
modifier: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
name: cytidylate kinase (dCMP,dCTP),nuclear
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM ksi pre15 g
has only substance units: false
is: HMDB00175
is: SBO:0000247
boundary condition: false
is: C00130
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
name: keratan sulfate I biosynthesis, precursor 15
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:58053
constant: false

metaM h2o2 x
initial concentration: 1.0
is: CHEBI:16240
type: Species
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
is: SBO:0000247
boundary condition: false
constant: false
name: Hydrogen peroxide
has only substance units: false
is: HMDB03125

metaR r0812
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
product: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
kinetic law: MODEL1310110003#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.41
modifier: MODEL1310110003#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_a4c3b0b7_e50e_442a_aea3_00f23e80bd31
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: ND6
constant: false
is: Q7GXZ1
initial amount: NaN
type: Species
is encoded by: hsa:4541
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_cbda278f_98df_4730_a16c_9c3e36eb9a1f
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
name: PRDX2
type: Species
is encoded by: hsa:7001

metaM HC00460 c
type: Species
has only substance units: false
is: CHEBI:58044
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: 2,5-dihydroxybenzoate
notes: FORMULA: C7H5O4 CHARGE: -1 INCHI: InChI=1S/C7H6O4/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,8-9H,(H,10,11)/p-1 EHMN_ABBREVIATION: C00628
constant: false

metaR r0750
reversible: true
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:3459552 NOTES:
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.85
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_3b91e911_16d0_4d45_b16b_3b926e72300f
constant: false
initial amount: NaN
boundary condition: true
name: _AA788780_1_c
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AA788780
has only substance units: false

metaM itaccoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
boundary condition: false
is: CHEBI:57381
is: SBO:0000247
is: HMDB03377
name: itaconyl-CoA(5-)
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN

metaR CHATn
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.6
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
is: SBO:0000176
type: Reaction
name: Choline O-acetyltransferase
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_234097a7_c0be_4ed9_bc2f_8e88de2046ce
initial amount: NaN
is encoded by: hsa:5105
name: PCK1
is: P35558
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_6a077794_143c_4880_a5d0_7a92026456d1
name: DGUOK
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q16854
type: Species
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:1716

metaR r1456
name: Transport reaction
fast: false
product: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
reversible: false
kinetic law: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#

metaM dudp n
type: Species
is: HMDB01000
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0
name: dUDP(3-)
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:60471

http://identifiers.org/biomodels.db/MODEL1310110003#_b3ee8105_f852_4e9c_b739_e10d8ce44c90
boundary condition: true
is encoded by: hsa:124935
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
constant: false
is: Q8N370
name: SLC43A2
initial amount: NaN

metaR MM7B2g
is: SBO:0000176
product: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.2.1.113
kinetic law: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reversible: false
is described by: ECO:0000000
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
modifier: MODEL1310110003#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_63436d59_c84b_4ae7_8a9e_28caccc3f62c
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: NDUFV2
initial concentration: NaN
is: P19404
has only substance units: false
is encoded by: hsa:4729
type: Species

metaR PSSA1 hs
notes: GENE_ASSOCIATION: (9791.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylcholine as substrate NJ
reversible: true
type: Reaction
name: Phosphatidylserine synthase homo sapiens
modifier: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000269
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.8.29
is: SBO:0000176

metaM HC02187 c
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: reverse-triiodthyronine
is: SBO:0000247
type: Species
is: CHEBI:28774
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)

http://identifiers.org/biomodels.db/MODEL1310110003#_80858ff8_0ae3_4c1d_a37b_78dd274cca70
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: _AI222095_1_m
type: Species
is encoded by: hsa:AI222095
constant: false
initial concentration: NaN

metaM 34dhpha c
has only substance units: false
name: (3,4-dihydroxyphenyl)acetate
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB01336
initial concentration: 1.0
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-2-1-5(3-7(6)10)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 EHMN_ABBREVIATION: C01161
boundary condition: false
is: CHEBI:17612

metaM coa r
is: CHEBI:57287
boundary condition: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: SBO:0000247
initial concentration: 1.0
is: HMDB01423
initial amount: NaN
constant: false
name: Coenzyme A
has only substance units: false
type: Species
is: C00010

metaM hgentis c
initial amount: NaN
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
type: Species
is: HMDB00130
initial concentration: 1.0
constant: false
is: CHEBI:16169
has only substance units: false
boundary condition: false
name: homogentisate
is: SBO:0000247

metaR r2532
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110003#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_bf778072_f25f_4562_a342_f77856901f5d
has only substance units: false
is encoded by: hsa:55349
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: CHDH
constant: false
is: Q8NE62
initial concentration: NaN

metaM HC01522 c
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
name: Gentisate aldehyde
type: Species
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
is: CHEBI:28508

http://identifiers.org/biomodels.db/MODEL1310110003#_01735dc3_86d9_4628_9d3e_fc108ae03dbb
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: ALDH3A1
type: Species
has only substance units: false
is: P30838
constant: false
initial concentration: NaN
is encoded by: hsa:218

http://identifiers.org/biomodels.db/MODEL1310110003#_0f122116_9176_4d9b_8d64_0bd69d6ec02f
is encoded by: hsa:126328
is: SBO:0000252
boundary condition: true
type: Species
is: C9JT23
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
name: NDUFA11

metaM cyan c
is: CHEBI:18407
type: Species
name: hydrogen cyanide
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB02084
has only substance units: false

metaM g1p e
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
name: alpha-D-glucose 1-phosphate(2-)
is: CHEBI:58601
is: HMDB01586
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM methf c
notes: FORMULA: C20H20N7O6 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
name: 5,10-Methenyltetrahydrofolate
is: HMDB01354
has only substance units: false
boundary condition: false
is: C00445
is: CHEBI:57455
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0

metaM coa x
initial amount: NaN
constant: false
is: CHEBI:57287
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: HMDB01423
name: Coenzyme A
has only substance units: false
is: C00010
type: Species

metaR r2328
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
reversible: true
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110003#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaR IPDDIx
is described by: ECO:0000134
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
name: isopentenyl-diphosphate D-isomerase
is version of: http://identifiers.org/ec-code/5.3.3.2
kinetic law: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
reversible: true
is: SBO:0000176
fast: false
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_e8b3002b_0e25_4adc_8c6e_b9e63a7fa4c6
initial amount: NaN
is encoded by: hsa:7001
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false
is: P32119
name: PRDX2

metaR DHFR
fast: false
is described by: ECO:0000254
kinetic law: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
reactant: MODEL1310110003#
modifier: MODEL1310110003#
name: dihydrofolate reductase
product: MODEL1310110003#

metaM lnlccoa m
name: linoleic coenzyme A
has only substance units: false
type: Species
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5462164
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB01064

http://identifiers.org/biomodels.db/MODEL1310110003#_075e7913_b7c2_45f3_b0ab_9961bd6c2677
is: SBO:0000252
boundary condition: true
constant: false
name: HK1
initial amount: NaN
is: P19367
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:3098

metaR r1450
product: MODEL1310110003#
is: SBO:0000176
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
fast: false
name: EC:1.3.3.6

metaM hdca e
notes: FORMULA: C16H31O2 CHARGE: -1
is: C00249
boundary condition: false
is: CHEBI:0
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00220
name: Hexadecanoate (n-C16:0)
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_aacf74aa_ff32_49e3_8507_864737574705
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
type: Species
name: _642502_1_c
initial concentration: NaN
is encoded by: hsa:642502

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_9aafa619_95c0_4f70_9049_8f7fbe9d159a
name: _X63359_1_c
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:X63359
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM 7thf e
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB06559
initial amount: NaN
constant: false
notes: FORMULA: C49H57N13O24 CHARGE: -8
name: heptaglutamyl folate (THF)
has only substance units: false

metaM 2mp2coa m
is: HMDB01011
name: 2-Methylprop-2-enoyl-CoA
is: CHEBI:27754
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
initial amount: NaN
boundary condition: false
constant: false
type: Species

metaR r2329
product: MODEL1310110003#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
kinetic law: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR EX sbt DASH d LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Sorbitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_a5b8a95a_ae27_4641_a5ac_063f727f6bc3
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: UROD
is encoded by: hsa:7389
initial concentration: NaN
type: Species
has only substance units: false
is: P06132

metaM udpgal g
is: CHEBI:58439
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00302
name: UDP-D-galactose(2-)
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0

metaR r0813
product: MODEL1310110003#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.9
is described by: ECO:0000000
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110003#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16847695,PMID:16983557 NOTES:
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_210f62e6_57be_4568_8558_e213368a09e3
is: Q9UBF8
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:5298
has only substance units: false
is: SBO:0000252
type: Species
name: PI4KB
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_0427e184_481e_45c3_8239_01ee3ff253bb
constant: false
type: Species
is: SBO:0000252
is: P11182
initial amount: NaN
initial concentration: NaN
name: DBT
has only substance units: false
is encoded by: hsa:1629
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_de5fd7f8_83aa_418a_9ad6_f212613129af
type: Species
has only substance units: false
is: Q9BY49
name: PECR
is encoded by: hsa:55825
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_9f383782_2f02_409d_83d9_08f96aa4bc2a
constant: false
name: SLCO3A1
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:28232
boundary condition: true
initial concentration: NaN
is: Q9UIG8

metaM HC02187 e
is: SBO:0000247
name: reverse-triiodthyronine
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:28774
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
type: Species
has only substance units: false

metaM g1p c
boundary condition: false
is: C00103
type: Species
initial amount: NaN
is: CHEBI:58601
name: D-Glucose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
initial concentration: 1.0
is: HMDB01586
is: SBO:0000247
constant: false
has only substance units: false

metaM odecoa c
type: Species
initial amount: NaN
name: Octadecenoyl-CoA (n-C18:1CoA)
is: HMDB01322
is: CHEBI:3793
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
initial concentration: 1.0

metaM uri c
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: C00299
constant: false
is: HMDB00296
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:16704
initial amount: NaN
name: Uridine
type: Species
is: SBO:0000247

metaR MTHFD2
reversible: true
is: SBO:0000176
modifier: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
notes: GENE_ASSOCIATION: (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:2786332 NOTES:NCD
kinetic law: MODEL1310110003#
type: Reaction
is described by: ECO:0000134
product: MODEL1310110003#
name: methylenetetrahydrofolate dehydrogenase (NAD)

http://identifiers.org/biomodels.db/MODEL1310110003#_aa0bfc79_74ed_4ec7_b931_e24ef9a29deb
type: Species
has only substance units: false
is encoded by: hsa:6574
constant: false
name: SLC20A1
initial concentration: NaN
initial amount: NaN
is: Q8WUM9
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_fae3d903_72f6_4f11_8fc5_ba19ee0f3a39
constant: false
is encoded by: hsa:226
has only substance units: false
name: ALDOA
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is: P04075

http://identifiers.org/biomodels.db/MODEL1310110003#_3049b558_d283_4d30_ad94_46c436315550
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: CA12
boundary condition: true
is encoded by: hsa:771

metaM ksii core2 pre10 g
constant: false
type: Species
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 10
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:28067
is: SBO:0000247

metaR C3STDH1Pr
kinetic law: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.1.1.170
reversible: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ
type: Reaction
fast: false
modifier: MODEL1310110003#
name: C-3 sterol dehydrogenase (4-methylzymosterol)
reactant: MODEL1310110003#

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM c226coa m
name: cervonyl coenzyme A
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
is: http://identifiers.org/pubchem.compound/47205479
is: C16169
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_439b81a2_8b15_4499_8c8b_16277eb82f1e
boundary condition: true
type: Species
name: FUT8
is encoded by: hsa:2530
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q546E0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_66a8dbad_2cb9_481f_924d_03356d9dfd44
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7296
has only substance units: false
type: Species
name: TXNRD1
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_7203b4bb_4083_471a_bba3_93bf89ea0d9c
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2639
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: GCDH
constant: false
is: Q92947

metaM lnlncg e
constant: false
initial amount: NaN
is: HMDB03073
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: CHEBI:32391
name: gamma-linolenate
boundary condition: false
has only substance units: false

metaR C4STMO1r
kinetic law: MODEL1310110003#
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110003#
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
type: Reaction
notes: GENE_ASSOCIATION: (6307.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:EC 1.-.-.- NCD ER version NJ
is version of: http://identifiers.org/ec-code/1.14.13.72
modifier: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#

metaR C4STMO2Pr
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:double check rxn specifics - see lit ref: Marijanovic, Molecular Endocrinology 2003 17:1715-1725 ER version NJ
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000176
fast: false
name: C-4 methyl sterol oxidase
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.170
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_132c1fcc_dc02_4065_9d88_1657a6151f25
is: Q9UHI5
boundary condition: true
is encoded by: hsa:23428
has only substance units: false
name: SLC7A8
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN

metaR HDCAtr
name: fatty acid transport via diffusion
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
reversible: true
reactant: MODEL1310110003#
type: Reaction

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_07334e0b_33a1_45f8_8bb1_34ac5213968c
initial concentration: NaN
initial amount: NaN
type: Species
name: SLC27A2
has only substance units: false
is: SBO:0000252
is: O14975
is encoded by: hsa:11001
boundary condition: true
constant: false

metaR PROD2m
name: Proline dehydrogenase (m)
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
reversible: false
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.5.99.8
type: Reaction
is: SBO:0000176
reactant: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
fast: false

metaR XYLTt
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
is: SBO:0000185
reversible: true
fast: false
type: Reaction
name: Xylitol transport via passive diffusion

metaM hdca c
initial amount: NaN
boundary condition: false
is: CHEBI:7896
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
name: palmitate
is: HMDB00220
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

metaR DHCR243r
is: SBO:0000176
kinetic law: MODEL1310110003#
name: 24-dehydrocholesterol reductase [Precursor]
fast: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
reversible: false
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.3.1.72
modifier: MODEL1310110003#
is described by: ECO:0000134
reactant: MODEL1310110003#
type: Reaction

metaM 5adtststerones e
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
constant: false
initial amount: NaN
name: 5alpha-Dihydrotestosterone sulfate
is: HMDB06278
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_f19b7945_5534_4c76_9bb1_f34ac6595078
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:6535
is: SBO:0000252
initial concentration: NaN
name: SLC6A8
is: B4DIA3

metaM C04849 e
type: Species
initial amount: NaN
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
has only substance units: false
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
boundary condition: false
is: SBO:0000247
is: CHEBI:57449
initial concentration: 1.0

metaM arachdcoa c
boundary condition: false
name: arachidonoyl-CoA(4-)
is: HMDB06523
initial amount: NaN
type: Species
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:57368

http://identifiers.org/biomodels.db/MODEL1310110003#_9775f3d4_234c_4cbe_8416_fe2c7679ea5b
is encoded by: hsa:249
initial amount: NaN
name: ALPL
is: B7Z4Y6
has only substance units: false
boundary condition: true
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaR HCO3 CLt
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
reactant: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
reversible: true
fast: false
product: MODEL1310110003#
name: bicarbonate transport (Cl-/HCO3- exchange)
is: SBO:0000185
kinetic law: MODEL1310110003#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110003#_58e395eb_5ded_42f6_8944_cf3d9f1ecc1f
is encoded by: hsa:27068
type: Species
is: F8WDN9
initial amount: NaN
constant: false
name: PPA2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_2b7b289a_32fa_4021_bf8e_f160495ce939
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: FOLR1
constant: false
is encoded by: hsa:2348
initial amount: NaN

metaM xyl D l
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
constant: false
is: SBO:0000247
type: Species
is: CHEBI:15936
name: aldehydo-D-xylose
initial amount: NaN

metaR IDOAASE1ly
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.76
is: SBO:0000176
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
type: Reaction
name: alpha-L-iduronidase, lysosomal
product: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_08f4d1a2_fd40_4629_8d72_feef01a2a44b
is: SBO:0000252
is: O95169
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:4714
name: NDUFB8
boundary condition: true
type: Species

metaM ach n
has only substance units: false
is: HMDB00895
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
is: CHEBI:15355
is: SBO:0000247
name: acetylcholine

metaM bildglcur r
initial amount: NaN
boundary condition: false
is: CHEBI:58471
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: HMDB03325
has only substance units: false
is: SBO:0000247
name: bis(beta-glucosyluronate)bilirubin

metaM dcacoa m
is: HMDB06404
type: Species
name: Decanoyl-CoA (n-C10:0CoA)
constant: false
is: C05274
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
is: CHEBI:61430
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_babad1b3_c6ae_4270_bfae_2a16824d02ab
is: SBO:0000252
constant: false
is encoded by: hsa:765
boundary condition: true
has only substance units: false
name: CA6
initial concentration: NaN
is: Q5FC00
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_1511f7ea_3971_4070_97be_bc9b5b8a2314
is: D3DX95
constant: false
is encoded by: hsa:1103
type: Species
name: CHAT
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM pa hs n
boundary condition: false
name: phosphatidate(2-)
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
is: CHEBI:57739
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_eff4816a_ee09_415d_a578_a9854492f5d6
initial amount: NaN
is encoded by: hsa:AA576959
name: _AA576959_1_c
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR r2110
is: SBO:0000185
fast: false
is described by: ECO:0000000
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_4c296b89_3c93_454f_bb23_f9a5e7649c14
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110003#_96e01a64_5cef_4d2a_9b4d_5968a69f0399
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:219
name: ALDH1B1
is: P30837
constant: false

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaM Tn antigen g
constant: false
type: Species
is: C04383
notes: FORMULA: C8H14NO5X CHARGE: 0
name: Tn antigen
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_8f4c6d74_10fe_4542_95e5_29017bbf55b8
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: _AA081045_1_c
constant: false
has only substance units: false
is encoded by: hsa:AA081045

http://identifiers.org/biomodels.db/MODEL1310110003#_92a0a488_6afb_4b08_9021_11225b2f762a
is: P28329
is: SBO:0000252
is encoded by: hsa:1103
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: CHAT
boundary condition: true
type: Species
constant: false

metaR PYRt2p
reactant: MODEL1310110003#
fast: false
reversible: true
kinetic law: MODEL1310110003#
is described by: ECO:0000269
modifier: MODEL1310110003#
type: Reaction
name: pyruvate peroxisomal transport via proton symport
product: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12705896,PMID:12739169,PMID:9786900 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110003#_42e11e9d_2b2a_4d91_ad4f_3c5bc12ecc93
boundary condition: true
constant: false
initial concentration: NaN
is: Q9UHW9
name: SLC12A6
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:9990
type: Species

metaR MM5cg
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
fast: false
product: MODEL1310110003#
reversible: false
modifier: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
kinetic law: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.113

metaR r1671
is: SBO:0000185
type: Reaction
reversible: true
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
product: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0541
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
is: SBO:0000176
modifier: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110003#
product: MODEL1310110003#

metaM chsterol m
has only substance units: false
is: SBO:0000247
is: CHEBI:16113
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial concentration: 1.0
is: HMDB00067
name: cholesterol
type: Species

metaM pa hs c
initial amount: NaN
is: CHEBI:57739
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
has only substance units: false
type: Species
name: phosphatidate(2-)

metaM man6p c
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB01078
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: D-Mannose 6-phosphate
constant: false
is: CHEBI:17369

metaR r2111
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
type: Reaction

metaM pmtcoa r
is: CHEBI:3454
boundary condition: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
initial amount: NaN
constant: false
is: C00154
type: Species
is: SBO:0000247
name: Palmitoyl-CoA (n-C16:0CoA)
initial concentration: 1.0
has only substance units: false
is: HMDB01338

http://identifiers.org/biomodels.db/MODEL1310110003#_29fcc3b2_f740_464f_867c_ec4bb29ebcec
constant: false
initial amount: NaN
is encoded by: hsa:BE966236
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _BE966236_1_c

metaM adp c
is: http://identifiers.org/pubchem.compound/3310
name: ADP
is: C00008
type: Species
is: HMDB01341
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:16761
initial amount: NaN

metaM atp n
type: Species
initial concentration: 1.0
initial amount: NaN
name: ATP(3-)
constant: false
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
has only substance units: false
is: CHEBI:57299
is: HMDB00538
is: SBO:0000247

metaR EX xolest2 hs LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: cholesterol ester (from FULLR2) exchange
type: Reaction

metaM m4masn g
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C46H77N2O35X CHARGE: 0
type: Species
has only substance units: false
constant: false
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: C05881
is: SBO:0000247
initial amount: NaN

metaM q10 c
name: ubiquinone-10
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: CHEBI:46245
is: HMDB01072

metaM pep m
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
name: Phosphoenolpyruvate
is: CHEBI:18021
boundary condition: false
type: Species
constant: false
is: C00074
initial amount: NaN
is: HMDB00263
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaR AG13T4g
modifier: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000176
reversible: false

metaR r0170
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
type: Reaction
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
modifier: MODEL1310110003#

metaR r1299
fast: false
product: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
is: SBO:0000185
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
name: Vesicular transport

metaM chsterol l
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00067
name: cholesterol
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: CHEBI:16113

metaM 5aizc c
is: CHEBI:58564
boundary condition: false
is: SBO:0000247
is: C04751
initial amount: NaN
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
type: Species
has only substance units: false
is: HMDB06273
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_9acc9f4d_6f31_477a_83dd_78e8f187d935
is encoded by: hsa:64077
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: LHPP
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: Q9H008

metaR r2338
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
is: SBO:0000185
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.19.1

metaM csn e
is: SBO:0000247
has only substance units: false
is: CHEBI:16040
is: HMDB00630
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
name: cytosine
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_27129665_9597_4970_bb10_750dc45a89d0
initial concentration: NaN
is encoded by: hsa:56623
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q9NRR6
type: Species
is: SBO:0000252
name: INPP5E
constant: false

metaM malttr e
constant: false
is: HMDB01262
boundary condition: false
initial amount: NaN
is: CHEBI:27931
has only substance units: false
initial concentration: 1.0
name: maltotriose
notes: FORMULA: C18H32O16 CHARGE: 0 INCHI: InChI=1S/C18H32O16/c19-1-4-7(22)8(23)12(27)17(31-4)34-15-6(3-21)32-18(13(28)10(15)25)33-14-5(2-20)30-16(29)11(26)9(14)24/h4-29H,1-3H2/t4-,5-,6-,7-,8+,9-,10-,11-,12-,13-,14-,15-,16+,17-,18-/m1/s1 EHMN_ABBREVIATION: C01835
type: Species
is: C01835
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_d6c3327c_eaeb_4335_8ea1_5d057b00ef1f
initial amount: NaN
name: GCSH
type: Species
initial concentration: NaN
is: P23434
is encoded by: hsa:2653
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252

metaR r0688
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction

metaR RE1517M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.3.99.13
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
reversible: true
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#
name: RE1517
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110003#

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaM dcholcoa x
is: HMDB06292
initial amount: NaN
name: chenodeoxycholoyl coenzyme a
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
has only substance units: false
is: CHEBI:28701

http://identifiers.org/biomodels.db/MODEL1310110003#_80918107_acf1_4853_9ed7_093d892d7120
is: SBO:0000252
name: EHHADH
type: Species
is encoded by: hsa:1962
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q9NY65
constant: false
initial concentration: NaN

metaM dcacoa c
is: C05274
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: false
is: HMDB06404
is: CHEBI:61430
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
name: Decanoyl-CoA (n-C10:0CoA)

metaR r2112
type: Reaction
reversible: true
kinetic law: MODEL1310110003#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
product: MODEL1310110003#
is described by: ECO:0000000

metaR N4Tg
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is: SBO:0000176
type: Reaction
name: N-acetylgalactosamine 4-beta-galactosyltransferase, Golgi apparatus
reactant: MODEL1310110003#
is described by: ECO:0000000
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110003#_cb17b6e3_d260_4f97_a94c_769c6a4e73a6
is encoded by: hsa:3158
is: P54868
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: HMGCS2
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_57b946b6_cbd4_4a87_b296_f224e9f9eb40
has only substance units: false
initial concentration: NaN
is: O43181
constant: false
is encoded by: hsa:4724
name: NDUFS4
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species

metaM sphs1p c
constant: false
has only substance units: false
type: Species
name: sphingosine 1-phosphate(1-)
is: CHEBI:60119
is: HMDB00277
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124

metaR r0002
is described by: ECO:0000000
type: Reaction
product: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
name: Active transport
kinetic law: MODEL1310110003#
is: SBO:0000185

metaM atp r
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:57299
initial amount: NaN
is: SBO:0000247
is: C00002
is: HMDB00538
name: ATP(4-)
type: Species
has only substance units: false

metaR ILETA
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reactant: MODEL1310110003#
is: SBO:0000176
modifier: MODEL1310110003#
is described by: ECO:0000269
fast: false
name: isoleucine transaminase
is version of: http://identifiers.org/ec-code/2.6.1.42
kinetic law: MODEL1310110003#
type: Reaction
reversible: true

metaR r2526
reactant: MODEL1310110003#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110003#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaR GAPD
kinetic law: MODEL1310110003#
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.2.1.12
reactant: MODEL1310110003#
name: glyceraldehyde-3-phosphate dehydrogenase
is: SBO:0000176
product: MODEL1310110003#
type: Reaction
fast: false

metaR F6Tg
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
modifier: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.68
name: glycoprotein 6-alpha-L-fucosyltransferase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_3dc6183f_2275_49e2_ace6_feacfdb644a5
initial amount: NaN
is: A0S0A7
is encoded by: hsa:4846
name: NOS3
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
constant: false

metaM lnlncg c
type: Species
name: gamma-linolenate
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
is: CHEBI:32391
is: SBO:0000247
boundary condition: false
is: HMDB03073
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_8b8a27a0_946e_4993_be3c_f5174430ca71
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2678
is: SBO:0000252
constant: false
initial amount: NaN
is: P19440
name: GGT1
has only substance units: false
type: Species

metaR r1931
is: SBO:0000185
kinetic law: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110003#
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
reversible: false
product: MODEL1310110003#
modifier: MODEL1310110003#

metaM hs deg20 l
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:16126
name: heparan sulfate, degradation product 20
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_223a4718_dd5e_4bed_8b6c_74d2a8134d6d
is: P07686
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
name: HEXB
type: Species
boundary condition: true
is encoded by: hsa:3074

metaR LTD4DP
fast: false
name: Leukotriene D4 dipeptidase
kinetic law: MODEL1310110003#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110003#
reversible: true
is described by: ECO:0000000
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ

metaM q10 e
constant: false
boundary condition: false
name: ubiquinone-10
is: SBO:0000247
is: CHEBI:46245
initial concentration: 1.0
is: HMDB01072
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

metaM citr L e
is: CHEBI:16349
is: SBO:0000247
constant: false
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
has only substance units: false
initial amount: NaN
name: citr_L[e]
type: Species
initial concentration: 1.0
is: HMDB00904
boundary condition: false

metaR SADT
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.25
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
product: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
name: sulfate adenylyltransferase
reversible: false

metaR EX 10fthf6glu LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](6) exchange
type: Reaction

metaR DOLPMT4 Uer
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
reversible: false
is described by: ECO:0000000
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_ca4d3ae8_5644_466b_8892_3c02b1d5e0f9
has only substance units: false
type: Species
is encoded by: hsa:27068
boundary condition: true
constant: false
initial amount: NaN
name: PPA2
initial concentration: NaN
is: SBO:0000252

metaR S6TASE2ly
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
product: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
kinetic law: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal

metaR PYRt2m
name: pyruvate mitochondrial transport via proton symport
fast: false
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6987111 NOTES:IF changed name from "tm" to "t2m" - NCD
is: SBO:0000185
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#

metaR GCHOLAt2
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
fast: false
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: (6554.1) or (6555.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12851823,PMID:7592981,PMID:8132774,PMID:9109432 NOTES:electrogenic uptake NJ
modifier: MODEL1310110003#
name: glycocholate transport via sodium cotransport

metaR DM fol
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaM gthrd m
constant: false
is: CHEBI:57925
is: HMDB00125
name: glutathionate(1-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false

metaM acald c
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00990
type: Species
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:15343
name: acetaldehyde

metaR ACHtn
name: Acetylcholin transport, nuclear trhough pores
fast: false
is described by: ECO:0000000
product: MODEL1310110003#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction

metaR GUAt
product: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000269
name: Guanine transport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
fast: false
type: Reaction
kinetic law: MODEL1310110003#

metaM csn c
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:16040
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00630
name: cytosine

http://identifiers.org/biomodels.db/MODEL1310110003#_01368bdf_d7a7_4067_9337_b50abd9f4897
name: SMPD3
is encoded by: hsa:55512
constant: false
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
is: A8K0T6
initial concentration: NaN
initial amount: NaN

metaM nh4 x
is: HMDB00051
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
name: Ammonium
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:28938
is: C01342
type: Species
constant: false

metaR ALADGLYexR
product: MODEL1310110003#
is: SBO:0000185
fast: false
reversible: true
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110003#
name: D-alanine/glycine reversible exchange
reactant: MODEL1310110003#
modifier: MODEL1310110003#

metaR CMPACNAtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reversible: false
is: SBO:0000185
product: MODEL1310110003#
name: CMP-Sia nuclear export

http://identifiers.org/biomodels.db/MODEL1310110003#_fbe84461_197f_4b20_8deb_3f37a58d1e0f
is encoded by: hsa:284111
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
name: SLC13A5
is: Q86YT5
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_b92ea8d1_2366_48dd_9e10_fae4a8674e7e
constant: false
boundary condition: true
is: P31937
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:11112
initial concentration: NaN
name: HIBADH
is: SBO:0000252

metaM pmtcoa m
has only substance units: false
is: CHEBI:57379
name: Palmitoyl-CoA (n-C16:0CoA)
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
is: C00154
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
is: HMDB01338

http://identifiers.org/biomodels.db/MODEL1310110003#_8cd591ce_5caa_4e0f_948b_c2d381d1f7b8
is: P03897
boundary condition: true
type: Species
name: ND3
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4537
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_bb9f0148_48a3_46ba_8bdc_559ac3a083e8
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: IVD
boundary condition: true
is encoded by: hsa:3712
type: Species
is: B3KVI7
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_1a456a1c_5ffe_418c_afbb_363a325f86fb
is: Q308M7
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:5169
initial concentration: NaN
name: ENPP3

metaM ksi pre30 g
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:58053
has only substance units: false
type: Species
is: C00130
name: keratan sulfate I biosynthesis, precursor 30
is: HMDB00175
is: SBO:0000247
boundary condition: false
notes: FORMULA: C219H350N15O184S9X CHARGE: -10

metaR LNLCCRNt
kinetic law: MODEL1310110003#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110003#
fast: false
product: MODEL1310110003#
type: Reaction

metaR GTHPm
modifier: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.11.1.12
fast: false
name: glutathione peroxidase, mitochondria
is version of: http://identifiers.org/ec-code/1.11.1.15
is described by: ECO:0000269
reactant: MODEL1310110003#

metaM gtp n
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01273
has only substance units: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: CHEBI:37565
boundary condition: false
name: GTP(4-)

metaM occoa m
name: Octanoyl-CoA (n-C8:0CoA)
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial amount: NaN
is: SBO:0000247
is: CHEBI:57386
constant: false
is: C01944
is: HMDB01070
type: Species

metaR r0545
modifier: MODEL1310110003#
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: true
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
type: Reaction

metaM dutp c
constant: false
boundary condition: false
is: CHEBI:17625
name: dUTP
initial concentration: 1.0
initial amount: NaN
type: Species
is: C00460
has only substance units: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
is: SBO:0000247
is: HMDB01191

metaR GLNLASEer
is: SBO:0000176
type: Reaction
reversible: true
is described by: ECO:0000000
name: gluconolactonase, endoplasmic reticulum
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD

metaM c226coa c
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: cervonyl coenzyme A
type: Species
initial amount: NaN
is: C16169
constant: false
is: http://identifiers.org/pubchem.compound/47205479
is: SBO:0000247

metaR RE3004M
is described by: ECO:0000000
name: RE3004
reversible: true
is: SBO:0000176
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.1.35

metaM 3oddcoa m
is: HMDB03937
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
name: 3-Oxododecanoyl-CoA
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:27868

metaR r0686
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.2.2
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
reactant: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
fast: false
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is described by: ECO:0000000
modifier: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

metaM pe hs r
initial amount: NaN
is: SBO:0000247
is: CHEBI:16038
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
type: Species
name: phosphatidylethanolamine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_d593dee6_2718_4bf2_8c5e_60a209e72a60
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:AL048840
is: SBO:0000252
constant: false
type: Species
name: _AL048840_1_c
initial concentration: NaN

metaR HPACtr
is: SBO:0000185
name: hydroxyphenylacetate transport via diffusion
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
type: Reaction
reactant: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_79a6204b_de37_4a25_832e_5a7720f17803
constant: false
boundary condition: true
name: BCKDHB
initial concentration: NaN
is encoded by: hsa:594
initial amount: NaN
has only substance units: false
is: P21953
is: SBO:0000252
type: Species

metaR ACALDtm
reversible: true
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
name: acetaldehyde mitochondrial diffusion
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
fast: false

metaR XOL27OHtm
name: 27 hydroxy cholesterol transport
reactant: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
type: Reaction
reversible: true
fast: false

metaR H2Otp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110003#
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110003#
product: MODEL1310110003#
name: H2O transport, peroxisomal

metaM acald e
name: acetaldehyde
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:15343
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
constant: false
is: HMDB00990

metaR NAIt
reversible: true
reactant: MODEL1310110003#
name: Na+ / iodide cotransport
product: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
fast: false
type: Reaction
is: SBO:0000185

metaR HSPASEly
is: SBO:0000176
name: heparan sulfate proteoglycan protease, lysosome (endosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:12782143,PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#
type: Reaction

metaR r2334
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM dgsn m
name: Deoxyguanosine
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: HMDB00085
is: CHEBI:17172
is: C00330
has only substance units: false
is: SBO:0000247
constant: false

metaM gtp m
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP
constant: false
is: CHEBI:37565
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01273
has only substance units: false
initial concentration: 1.0
is: C00044

http://identifiers.org/biomodels.db/MODEL1310110003#_6606339c_c423_4973_95f0_0dde74efeadb
initial concentration: NaN
name: ABAT
type: Species
has only substance units: false
is: P80404
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:18
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_9fac43e6_0894_4129_af7e_49f841003071
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:343
is: SBO:0000252
has only substance units: false
is: O94778
name: AQP8

metaR r2525
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110003#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#

metaM udpg r
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
type: Species
constant: false
is: CHEBI:58367
initial amount: NaN
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
is: HMDB00286
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_960579d1_089a_4f42_84c9_5c4966c4b515
constant: false
name: ENPP3
has only substance units: false
is encoded by: hsa:5169
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is: Q308M7

metaM retinal 11 cis c
constant: false
type: Species
boundary condition: false
is: HMDB02152
name: 11-cis-retinal
is: SBO:0000247
initial amount: NaN
is: CHEBI:16066
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+

http://identifiers.org/biomodels.db/MODEL1310110003#_f767e8b4_51bc_44f5_af34_d8f8c2ee6bfe
type: Species
name: GCDH
is: Q92947
has only substance units: false
is encoded by: hsa:2639
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_849ba202_c87e_43fe_9855_e333602fe410
is: O95258
is encoded by: hsa:9016
name: SLC25A14
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR CMPSASn
reversible: false
is: SBO:0000176
modifier: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.7.43
fast: false
is described by: ECO:0000304
name: CMP sialic acid synthase, nuclear
kinetic law: MODEL1310110003#
type: Reaction

metaR PYRt2r
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
type: Reaction
product: MODEL1310110003#
is: SBO:0000185
reversible: true
fast: false
name: pyruvate reversible transport via proton symport
is described by: ECO:0000269

metaR r2193
is: SBO:0000185
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110003#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM atp m
boundary condition: false
is: HMDB00538
type: Species
name: ATP(4-)
is: CHEBI:57299
initial amount: NaN
initial concentration: 1.0
is: C00002
constant: false
has only substance units: false
is: SBO:0000247

metaR r2333
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true
fast: false
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
kinetic law: MODEL1310110003#
is: SBO:0000185

metaR H2Otm
product: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#
name: H2O transport, mitochondrial
modifier: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
is described by: ECO:0000269
type: Reaction

metaM CE5854 e
name: gama-CEHC-glucuronide
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
has only substance units: false
constant: false
is: CHEBI:27485
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB02710
initial concentration: 1.0

metaM acetone m
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
name: acetone
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:15347
is: HMDB01659
has only substance units: false
initial amount: NaN

metaM g1m8masn r
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C76H127N2O60X CHARGE: 0
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false
is: SBO:0000247
is: C05875

metaM HC01603 c
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
is: C00234
has only substance units: false
constant: false
type: Species
boundary condition: false
name: 10-Formyltetrahydrofolate
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_ccdc06f8_74f4_4672_abce_8336f0bb82ae
initial amount: NaN
is encoded by: hsa:492
is: Q16720
name: ATP2B3
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false

metaR r1298
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110003#
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110003#
name: Vesicular transport
fast: false
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_b330c5a9_aaa8_486b_afd8_dc98874095e7
has only substance units: false
type: Species
is: SBO:0000252
name: _AI291895_1_c
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI291895
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_42dab861_8e97_4e97_b7d0_3eb2910f39cb
is: SBO:0000252
is: P55916
name: UCP3
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7352

metaR ST8SIA12
kinetic law: MODEL1310110003#
name: Beta-galactoside alpha-2,3-sialyltransferase
reversible: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.8
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reactant: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
fast: false
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_6ba9b081_78b3_414b_a7d3_ddb99d5484fb
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: P82251
constant: false
has only substance units: false
name: SLC7A9
type: Species
is encoded by: hsa:11136
initial concentration: NaN

metaM biocyt e
is: C05552
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB03134
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7886
name: Biocytin

metaM HC02180 c
constant: false
name: thromboxane-b2
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
initial amount: NaN
is: CHEBI:28728
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_6e85f4a9_f232_4758_a3a5_3034b46032ad
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:AV717590
type: Species
name: _AV717590_1_m

http://identifiers.org/biomodels.db/MODEL1310110003#_140d4f10_5a05_4fd3_848a_38e662a8008e
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:223
name: ALDH9A1
is: P49189
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaR H2Otn
reversible: true
product: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110003#
type: Reaction
name: H2O transport, nuclear
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110003#
fast: false

metaM 1p3h5c m
is: HMDB01369
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
constant: false
is: CHEBI:6151
is: SBO:0000247
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false

metaR r0437
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.13
reactant: MODEL1310110003#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_f1b12dbf_d207_4df3_8bb2_eadfd8f4783a
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4722
has only substance units: false
is: O75489
name: NDUFS3
constant: false

metaR r2332
product: MODEL1310110003#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
kinetic law: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110003#
is described by: ECO:0000000
type: Reaction

metaR URIK1
name: uridine kinase (ATP:Uridine)
type: Reaction
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
is: SBO:0000176
reactant: MODEL1310110003#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.1.48

metaR DOPACHRMISO
modifier: MODEL1310110003#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.14.18.1
product: MODEL1310110003#
name: L-dopachrome isomerase 1
is described by: ECO:0000269
is: SBO:0000176
reversible: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (7299.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.18.1 Confidence Level: 4 AUTHORS: PMID:5294951 NOTES:SAB
kinetic law: MODEL1310110003#

metaR r0683
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
reversible: false
product: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
fast: false
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
modifier: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM chsterol r
boundary condition: false
type: Species
is: HMDB00067
initial amount: NaN
name: cholesterol
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:16113

http://identifiers.org/biomodels.db/MODEL1310110003#_5599f9a3_3ccc_472e_a5f8_c401954b0625
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P45954
is encoded by: hsa:36
constant: false
name: ACADSB
type: Species
is: SBO:0000252

metaR AG13T6g
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_b4df861d_90e1_4347_a992_35d2eb7d2433
name: NDUFA2
is: O43678
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:4695
boundary condition: true
initial concentration: NaN
constant: false

metaR r1670
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
is described by: ECO:0000000
fast: false
modifier: MODEL1310110003#
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM aacoa m
is: HMDB01484
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial concentration: 1.0
constant: false
is: CHEBI:57286
is: SBO:0000247
has only substance units: false
name: acetoacetyl-CoA(4-)

metaM xol25oh r
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
initial amount: NaN
has only substance units: false
constant: false
is: HMDB06247
type: Species
boundary condition: false
name: 25-hydroxycholesterol
is: SBO:0000247
is: CHEBI:42977
initial concentration: 1.0

metaR GLCNACASE1ly
reactant: MODEL1310110003#
name: alpha-N-acetylglucosaminidase, lysosomal
product: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
modifier: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.50
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_b0aca556_0515_4f36_9b57_82b090be94df
has only substance units: false
initial concentration: NaN
name: PRPS1L1
is: SBO:0000252
is encoded by: hsa:221823
constant: false
type: Species
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_1448bb7c_e069_40b8_baca_5acd097067f9
boundary condition: true
is encoded by: hsa:8818
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: DPM2
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_bd6a9bff_11ba_498e_a692_3714d77349b4
is: SBO:0000252
constant: false
has only substance units: false
type: Species
is encoded by: hsa:2954
initial amount: NaN
boundary condition: true
name: GSTZ1
initial concentration: NaN

metaR ST8SIA11
reversible: false
type: Reaction
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.99.8
reactant: MODEL1310110003#
product: MODEL1310110003#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#
name: Beta-galactoside alpha-2,3-sialyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ

metaR VALt5m
reversible: true
name: Valine reversible mitochondrial transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
product: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110003#
type: Reaction

metaR RPE
is described by: ECO:0000000
kinetic law: MODEL1310110003#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/5.1.3.1
name: ribulose 5-phosphate 3-epimerase
reactant: MODEL1310110003#
fast: false
is: SBO:0000176
product: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP

metaM chsterol e
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
boundary condition: false
type: Species
name: cholesterol
is: CHEBI:16113
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00067
is: SBO:0000247

metaM pi r
is: C00009
name: hydrogenphosphate
has only substance units: false
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM grdp x
initial concentration: 1.0
is: HMDB01285
initial amount: NaN
is: CHEBI:58057
has only substance units: false
type: Species
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
constant: false
boundary condition: false
name: geranyl diphosphate(3-)
is: SBO:0000247

metaR DPCOAK
modifier: MODEL1310110003#
reversible: false
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (80347.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.7.3
product: MODEL1310110003#
is: SBO:0000176
name: dephospho-CoA kinase

http://identifiers.org/biomodels.db/MODEL1310110003#_4e24f5d9_547c_4bb7_8a04_7eae3cc617d8
type: Species
is encoded by: hsa:57835
is: SBO:0000252
name: SLC4A5
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false

metaM etoh e
is: HMDB00108
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
is: CHEBI:16236
boundary condition: false
name: ethanol
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_38bfea73_dba9_45dd_ba52_6724d04057bc
type: Species
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:84706
initial concentration: NaN
is: SBO:0000252
name: GPT2
is: Q8TD30
has only substance units: false

metaR r2118
modifier: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#

metaR r0179
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000000
kinetic law: MODEL1310110003#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
reversible: true
reactant: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:

metaM dcholcoa r
type: Species
name: chenodeoxycholoyl coenzyme a
initial amount: NaN
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28701
has only substance units: false
boundary condition: false
is: HMDB06292

metaM atp x
is: HMDB00538
initial amount: NaN
boundary condition: false
name: ATP(4-)
has only substance units: false
type: Species
initial concentration: 1.0
is: C00002
is: CHEBI:57299
is: SBO:0000247
constant: false

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaR r0549
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.6.5.3
kinetic law: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
fast: false
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.6.99.3
modifier: MODEL1310110003#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/6.1.1.17
is: SBO:0000176

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_7db012fd_d2af_477e_b1ee_5064b5bafa90
boundary condition: true
is: P78330
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: PSPH
is encoded by: hsa:5723
type: Species

metaM acetone c
type: Species
is: CHEBI:15347
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01659
name: acetone
has only substance units: false

metaR r2331
product: MODEL1310110003#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110003#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110003#

metaR r1020
is described by: ECO:0000000
reversible: true
name: Postulated transport reaction
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
product: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
fast: false

metaM HC01409 m
initial amount: NaN
boundary condition: false
is: CHEBI:27540
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
name: Hexanoyl-CoA
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_e6fa0d94_05d2_43a6_8ee6_4624f5dad08f
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:4512
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: COX1
type: Species
is: Q7GXY8

metaR r2195
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110003#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
is described by: ECO:0000000
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110003#
modifier: MODEL1310110003#

metaM HC01115 c
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
name: NeuNGc
is: CHEBI:29025
initial amount: NaN
constant: false
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410

metaR DOLGLCP Uter
kinetic law: MODEL1310110003#
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
is: SBO:0000185
reversible: false
reactant: MODEL1310110003#
fast: false
is described by: ECO:0000000
product: MODEL1310110003#
type: Reaction

metaR r2119
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110003#
is described by: ECO:0000000
modifier: MODEL1310110003#
reversible: true
product: MODEL1310110003#

metaM gthrd c
initial amount: NaN
is: HMDB00125
is: C00051
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
type: Species
constant: false
is: CHEBI:57925
boundary condition: false
name: Reduced glutathione
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_38871b77_8f96_4550_9c12_70954011a1ce
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: ACHE
initial concentration: NaN
has only substance units: false
is encoded by: hsa:43
is: P22303

metaM h2o c
constant: false
has only substance units: false
boundary condition: false
is: HMDB02111
type: Species
initial concentration: 1.0
name: H2O
is: C00001
is: CHEBI:3303
initial amount: NaN
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0

metaR r0321
product: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
reversible: false
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is version of: http://identifiers.org/ec-code/6.3.5.2
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
kinetic law: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_af3f103f_8200_4d64_bb42_b2dad4fe3b61
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: Q7GXY9
is: SBO:0000252
initial amount: NaN
name: ND2
boundary condition: true
is encoded by: hsa:4536

metaR D LACt2
type: Reaction
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
modifier: MODEL1310110003#
is described by: ECO:0000269
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
reversible: true
name: D-lactate transport via proton symport
is: SBO:0000185

metaR r0178
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/2.5.1.21
product: MODEL1310110003#
is described by: ECO:0000000
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
reversible: true

metaR r0060
type: Reaction
reversible: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110003#
name: L-serine ammonia-lyase Glycine, serine and threonine metabolism EC:4.3.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.3.1.17 Confidence Level: 0 AUTHORS: PMID:4433562 NOTES:
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#

metaR RE1530C
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
product: MODEL1310110003#
is: SBO:0000176
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
name: RE1530
type: Reaction
reversible: true
is described by: ECO:0000000

metaR ECOAH9m
is described by: ECO:0000304
type: Reaction
fast: false
reversible: true
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
modifier: MODEL1310110003#
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110003#
is: SBO:0000176
reactant: MODEL1310110003#

metaM nh4 m
type: Species
is: SBO:0000247
name: Ammonium
initial concentration: 1.0
has only substance units: false
is: HMDB00051
constant: false
initial amount: NaN
is: C01342
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: CHEBI:28938

metaR r2330
is: SBO:0000185
reactant: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110003#
reversible: true
product: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2

metaM fad e
type: Species
is: C00016
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:16238
initial amount: NaN
is: HMDB01248
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
name: Flavin adenine dinucleotide oxidized

metaM chsterol c
initial concentration: 1.0
constant: false
is: CHEBI:16113
name: cholesterol
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
boundary condition: false
is: HMDB00067
initial amount: NaN

metaM aacoa c
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
has only substance units: false
initial concentration: 1.0
constant: false
name: Acetoacetyl-CoA
is: C00332
initial amount: NaN
is: SBO:0000247
is: HMDB01484
type: Species
boundary condition: false
is: CHEBI:57286

http://identifiers.org/biomodels.db/MODEL1310110003#_a21ce247_ed5e_421f_aac8_10943fee8a7c
is: P36969
initial amount: NaN
name: GPX4
constant: false
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:2879

http://identifiers.org/biomodels.db/MODEL1310110003#_3175557f_d4fb_451d_a824_adecddac8ae5
boundary condition: true
type: Species
initial concentration: NaN
name: _D29675_1_c
has only substance units: false
is encoded by: hsa:D29675
constant: false
initial amount: NaN
is: SBO:0000252

metaR r1109
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_7ca18f16_c4c5_4151_be9a_22469da5071b
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:6554
has only substance units: false
is: SBO:0000252
is: B2RA41
type: Species
name: SLC10A1

http://identifiers.org/biomodels.db/MODEL1310110003#_b933c016_1c08_450f_920c_b6cd98b5ad85
is encoded by: hsa:594
is encoded by: hsa:1629
initial amount: NaN
type: Species
boundary condition: true
name: DBT:DLD:BCKDHA:BCKDHB
has only substance units: false
initial concentration: NaN
has part: P11182
has part: P21953
is: SBO:0000297
constant: false
has part: B4DP47
is encoded by: hsa:593

metaM CE2417 m
is: CHEBI:28387
type: Species
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
constant: false
initial amount: NaN
is: HMDB11123
initial concentration: 1.0
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM etoh c
notes: FORMULA: C2H6O CHARGE: 0 INCHI: InChI=1S/C2H6O/c1-2-3/h3H,2H2,1H3 HEPATONET_1.0_ABBREVIATION: HC00377 EHMN_ABBREVIATION: C00469
has only substance units: false
initial amount: NaN
name: ethanol
initial concentration: 1.0
is: CHEBI:16236
type: Species
is: HMDB00108
is: SBO:0000247
constant: false
boundary condition: false

metaR LEUt4
notes: GENE_ASSOCIATION: (81539.1) or (84889.1) or (6520.1) or (6542.1) or (6541.1) or (11254.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10391915,PMID:10891391,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:1376926,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
name: L-leucine transport in via sodium symport
reactant: MODEL1310110003#
type: Reaction
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110003#
fast: false
is: SBO:0000185
modifier: MODEL1310110003#
product: MODEL1310110003#

metaR S6T9g
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110003#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110003#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_0a371aa4_917b_4fdc_8b0f_0127a8f019c1
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:1632
type: Species
boundary condition: true
name: ECI1
is: SBO:0000252
is: P42126
initial amount: NaN

metaM Ssq23epx r
initial amount: NaN
type: Species
is: CHEBI:15441
has only substance units: false
is: SBO:0000247
boundary condition: false
name: (S)-2,3-epoxysqualene
initial concentration: 1.0
constant: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
is: HMDB01188

metaR r0434
fast: false
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is: SBO:0000176
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
product: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110003#
reactant: MODEL1310110003#

metaR ECOAH12m
kinetic law: MODEL1310110003#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is described by: ECO:0000304
type: Reaction
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
reactant: MODEL1310110003#
fast: false
modifier: MODEL1310110003#

metaM nh4 n
name: ammonium
is: CHEBI:28938
boundary condition: false
has only substance units: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
initial concentration: 1.0

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaR r2197
modifier: MODEL1310110003#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110003#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false

metaR r1106
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
kinetic law: MODEL1310110003#
name: Postulated transport reaction
type: Reaction

metaR r1579
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaR UMPK2n
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (CTP),nuclear
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_f013477b_f0c4_4b3a_b0b2_19943f1931dd
boundary condition: true
type: Species
initial concentration: NaN
name: PLCB1
initial amount: NaN
has only substance units: false
is encoded by: hsa:23236
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_0cc85200_4ae2_4e5f_ac16_ff61f4a77a34
name: KL
boundary condition: true
initial amount: NaN
type: Species
is: Q9UEF7
is encoded by: hsa:9365
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN

metaR r1578
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000

metaR EX 5dhf LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (DHF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_e9d6b205_ee0f_452f_ae7e_60ee1cdbb9d5
is: P20020
has only substance units: false
is encoded by: hsa:490
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
name: ATP2B1

metaM CE4872 c
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
initial concentration: 1.0
is: HMDB00127
type: Species
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
has only substance units: false
is: CHEBI:15748
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_fe8d2077_459e_4cd7_a2de_1a1409a163bf
name: ALG1
boundary condition: true
is: SBO:0000252
is: Q9BT22
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:56052
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_a84fe4cc_65f4_4bb4_ad4f_f26613f90271
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:10423
is: O14735
name: CDIPT
is: SBO:0000252
constant: false

metaR RE3272N
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
name: RE3272
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
reversible: true

metaR RE3568C
fast: false
product: MODEL1310110003#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110003#
is described by: ECO:0000000
name: RE3568
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110003#

metaM q10 m
is: HMDB01072
boundary condition: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:46245
is: SBO:0000247
constant: false
initial amount: NaN
name: ubiquinone-10

http://identifiers.org/biomodels.db/MODEL1310110003#_9f3f2199_d9eb_426d_9578_26c8505e8224
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:6555
is: Q12908
initial concentration: NaN
name: SLC10A2
initial amount: NaN
has only substance units: false

metaM gthrd e
name: glutathionate(1-)
type: Species
constant: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00125
has only substance units: false

metaR EX HC01444 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Galactosylglycerol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_362dadac_ab75_4d26_98b7_1e3e00d72774
is: SBO:0000252
type: Species
is encoded by: hsa:117247
initial concentration: NaN
name: SLC16A10
is: Q8TF71
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

metaR r0963
reversible: false
name: Facilitated diffusion
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14739191,PMID:14977409,PMID:14998787,PMID:16109384,PMID:16171773,PMID:16750224 NOTES:
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_d2fef1a2_d370_466f_9b78_edb4bef2f2bf
initial concentration: NaN
is encoded by: hsa:H45672
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: _H45672_1_m
type: Species

metaM mpdol U c
is: CHEBI:18396
initial concentration: 1.0
boundary condition: false
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20

http://identifiers.org/biomodels.db/MODEL1310110003#_cececb51_6eb2_4e29_82d9_3ba06df9bca5
boundary condition: true
type: Species
is encoded by: hsa:146712
has only substance units: false
constant: false
is: Q67FW5
name: B3GNTL1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR MTHFD2m
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.9
is described by: ECO:0000254
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
product: MODEL1310110003#

metaR r2196
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaR RPI
type: Reaction
reversible: true
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
is: SBO:0000176
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/5.3.1.6
fast: false
is described by: ECO:0000000
name: ribose-5-phosphate isomerase
modifier: MODEL1310110003#
reactant: MODEL1310110003#

metaM g6p c
is: CHEBI:61548
is: HMDB01401
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
name: D-Glucose 6-phosphate
has only substance units: false
is: C00092

http://identifiers.org/biomodels.db/MODEL1310110003#_f25f8094_4c1f_46f1_bdf2_7dd3251690dc
initial amount: NaN
is: B1AM93
boundary condition: true
name: NDUFA8
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4702

metaM fad c
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: C00016
is: SBO:0000247
is: CHEBI:16238
constant: false
initial amount: NaN
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: HMDB01248
name: Flavin adenine dinucleotide oxidized

http://identifiers.org/biomodels.db/MODEL1310110003#_fc290b0f_21ba_4e02_ad52_e84317888c0d
is: SBO:0000252
name: ACSL3
initial concentration: NaN
is encoded by: hsa:2181
constant: false
is: O95573
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true

metaM cl e
is: SBO:0000247
is: C00115
name: Chloride
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: Cl CHARGE: -1
is: CHEBI:3966
is: HMDB00492
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_0ee709f2_c1f6_46bc_ba80_2a9f218d463e
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:6515
is: P11169
initial amount: NaN
initial concentration: NaN
name: SLC2A3
constant: false
is: SBO:0000252

metaR EX ha LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_2e7a57ed_3df9_417c_b9f9_417e1e1ef08f
is encoded by: hsa:23057
initial concentration: NaN
name: NMNAT2
constant: false
is: Q9BZQ4
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

metaR r0960
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
reactant: MODEL1310110003#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_a3f0dfb1_3425_4245_8fa1_028c7b26e39c
constant: false
boundary condition: true
initial amount: NaN
is: A1L4Q0
name: DGKE
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8526
has only substance units: false
type: Species

metaM Tn antigen l
is: SBO:0000247
notes: FORMULA: C8H14NO5X CHARGE: 0
boundary condition: false
name: Tn antigen
is: C04383
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaR EX glyphe LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylphenylalaine
type: Reaction

metaR NADS2
name: NAD synthase (glutamine-hydrolysing)
reversible: false
is: SBO:0000176
product: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/6.3.5.1
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_5f5afab7_1bdd_4f2d_97fc_e9171d24822d
initial amount: NaN
is: SBO:0000252
is: P78542
constant: false
type: Species
is encoded by: hsa:3098
name: HK1
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_2f8c156a_623a_4d86_9410_2626998c7d24
is: SBO:0000252
boundary condition: true
is: D9HTE9
initial concentration: NaN
type: Species
name: SLC25A1
has only substance units: false
is encoded by: hsa:6576
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_bd74bfd0_036d_4d4b_ab4d_2a5e54af20ce
is: SBO:0000252
name: NME1
is encoded by: hsa:4830
initial amount: NaN
type: Species
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_d785fe1f_6d25_4231_a665_1dadcb9a3712
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:222
has only substance units: false
type: Species
is: P48448
name: ALDH3B2
constant: false
initial concentration: NaN

metaM nmn c
constant: false
is: C00455
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
name: NMN
is: CHEBI:14649
is: HMDB00229
type: Species
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
has only substance units: false

metaR r2199
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110003#
fast: false
type: Reaction
modifier: MODEL1310110003#
is described by: ECO:0000000
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
is: SBO:0000185

metaM sphs1p e
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false
initial amount: NaN
is: CHEBI:60119
is: HMDB00277
name: sphingosine 1-phosphate(1-)
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_288e9495_c70f_455f_877a_09875365992e
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: ACO1
boundary condition: true
is encoded by: hsa:48
initial amount: NaN
is: SBO:0000252
is: P21399

metaM retinol e
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00305
name: retinol
is: SBO:0000247
constant: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
type: Species
is: CHEBI:50211

metaR r2114
kinetic law: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_ac473854_df70_4785_8925_312574f2e2d0
is: P52824
name: DGKQ
type: Species
is encoded by: hsa:1609
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR ACNMLr
reversible: true
name: N-Acetylneuraminate lyase (reversible)
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 4.1.3.3 Confidence Level: 2 AUTHORS: NOTES:JLR
kinetic law: MODEL1310110003#
is: SBO:0000176
reactant: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_c2a4fadd_bb46_49f8_a65d_58d2455db9d3
initial concentration: NaN
is encoded by: hsa:43
name: ACHE
type: Species
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_b8f62a91_a650_4fa5_8e01_60241fbbabe7
is encoded by: hsa:160287
has only substance units: false
constant: false
boundary condition: true
is: Q6ZMR3
initial amount: NaN
type: Species
name: LDHAL6A
is: SBO:0000252
initial concentration: NaN

metaR MMEm
modifier: MODEL1310110003#
is: SBO:0000176
fast: false
reversible: true
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.1.99.1
name: methylmalonyl-CoA epimerase/racemase
product: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_b0ca6c7f_8c0b_4900_b288_07070ec74fa3
is encoded by: hsa:8527
is: Q16760
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
constant: false
name: DGKD
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_e1aac743_c79d_4bf6_b3d8_3657ae276475
initial amount: NaN
is: P48065
type: Species
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:6539
has only substance units: false
name: SLC6A12

metaR P4508B13r
reversible: false
reactant: MODEL1310110003#
name: sterol 12-alpha-hydroxylase (nadh)
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.14.13.95
is described by: ECO:0000269
kinetic law: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (1582.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ - added, substrates by analogy to other xol hydroxylase reactions (NADH and NADPH can both be used)
is: SBO:0000176
modifier: MODEL1310110003#
type: Reaction

metaM citr L c
has only substance units: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:16349
is: HMDB00904
constant: false
name: L-citrulline
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277

http://identifiers.org/biomodels.db/MODEL1310110003#_f6b81708_3eee_413d_a32b_e91be705b10d
is: P11586
name: MTHFD1
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:4522
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN

metaM 1p3h5c c
initial concentration: 1.0
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: HMDB01369
is: SBO:0000247
constant: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
is: CHEBI:6151

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_708a94e9_41d9_4c20_956f_86869dee2843
has only substance units: false
is encoded by: hsa:52
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ACP1
is: Q59EH3
type: Species

metaR r0739
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
type: Reaction
reversible: true
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: PMID:5487878,PMID:6338006,PMID:6379302 NOTES:
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.85
name: alcohol dehydrogenase Bile acid biosynthesis EC:1.1.1.1

metaR r2198
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110003#
reversible: true
fast: false
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110003#

metaR r2115
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
is: SBO:0000185
reactant: MODEL1310110003#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_a63ad740_8a73_4959_9aae_7aea74757794
type: Species
name: ACAD8
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is: Q6ZWP6
initial concentration: NaN
is encoded by: hsa:27034

http://identifiers.org/biomodels.db/MODEL1310110003#_def642fa_295d_4aa4_bcd6_f5808793896c
initial amount: NaN
is encoded by: hsa:6648
type: Species
is: SBO:0000252
boundary condition: true
name: SOD2
initial concentration: NaN
has only substance units: false
is: P04179
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_30a10510_74c0_4a4d_92a8_71ab1650563c
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaM acald m
boundary condition: false
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
type: Species
is: HMDB00990
initial amount: NaN
has only substance units: false
is: CHEBI:15343
constant: false
is: SBO:0000247
name: acetaldehyde

metaM 4mlacac c
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB02052
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1- HEPATONET_1.0_ABBREVIATION: HC00635 EHMN_ABBREVIATION: C01036
is: CHEBI:17105
name: 4-maleylacetoacetate
boundary condition: false

metaM pi x
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00973
type: Species
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
name: hydrogenphosphate
has only substance units: false
is: CHEBI:43474

http://identifiers.org/biomodels.db/MODEL1310110003#_9224bb05_11e4_4fec_bcb1_6542a69e00d5
constant: false
name: MGAT1
is encoded by: hsa:4245
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
is: P26572

metaR MI134P4P
reactant: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
type: Reaction
fast: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: false
is described by: ECO:0000000
name: inositol-1,3,4-trisphosphate 4-phosphatase

metaR CITRtm
kinetic law: MODEL1310110003#
type: Reaction
name: citrulline mitochondrial transport via proton antiport
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
fast: false

metaR LNLCt
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110003#
name: Linoleic acid (n-C18:2) transport in via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
type: Reaction

metaM core2 g
type: Species
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:15876
name: Core 2
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_272942b7_9947_4d1b_be34_97c9add7f6f8
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2731
constant: false
is: P23378
name: GLDC
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_2e476c6d_587c_4fd7_8da7_a08b6825b1e5
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3635
constant: false
type: Species
initial concentration: NaN
is: Q92835
name: INPP5D

http://identifiers.org/biomodels.db/MODEL1310110003#_245a6509_40c3_4b95_bc81_22ca1bb45ec7
boundary condition: true
type: Species
constant: false
is encoded by: hsa:9517
has only substance units: false
is: SBO:0000252
name: SPTLC2
initial amount: NaN
is: O15270
initial concentration: NaN

metaR G14T3g
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110003#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
product: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_b9294cdb_6d07_453a_9ab6_44a890067d53
initial amount: NaN
name: ALDH3A1
has only substance units: false
initial concentration: NaN
is: P30838
constant: false
boundary condition: true
type: Species
is encoded by: hsa:218
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_c854587f_8cdc_41a9_bb1b_549a3b2b2380
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:276
name: AMY1A
is: P04745

metaM pmtcoa c
constant: false
notes: FORMULA: C37H62N7O17P3S CHARGE: -4
has only substance units: false
type: Species
is: HMDB01338
name: Palmitoyl-CoA (n-C16:0CoA)
is: C00154
is: CHEBI:3454
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR ENGASE2ly
reactant: MODEL1310110003#
name: endo-beta-N-acetylglucosaminidase, lysosomal
is: SBO:0000176
kinetic law: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110003#_80180675_0619_48f2_81b2_b65ab44d4a3d
name: PANK1
type: Species
constant: false
is encoded by: hsa:53354
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_bf6be227_210f_4043_a431_533b88dcd67a
has only substance units: false
is: SBO:0000252
name: SLC5A3
boundary condition: true
constant: false
initial concentration: NaN
is: P53794
is encoded by: hsa:6526
type: Species
initial amount: NaN

metaR PGDI
type: Reaction
fast: false
modifier: MODEL1310110003#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.18
reactant: MODEL1310110003#
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/5.3.99.2
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
name: Prostaglandin-H2 D-isomerase [Precursor]
reversible: true

metaR r2116
is: SBO:0000185
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110003#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_31398aa9_9876_445c_b4cb_fb98fb967f41
name: HPD
boundary condition: true
initial amount: NaN
is: B3KQ63
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:3242

http://identifiers.org/biomodels.db/MODEL1310110003#_abbd43d6_a250_4b2d_9eb4_5e6c7174f334
is: Q96DU7
constant: false
name: ITPKC
initial amount: NaN
is encoded by: hsa:80271
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

metaM acetone e
has only substance units: false
is: HMDB01659
is: SBO:0000247
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
name: acetone
is: CHEBI:15347

metaM retinol c
initial concentration: 1.0
name: retinol
initial amount: NaN
is: HMDB00305
is: SBO:0000247
constant: false
has only substance units: false
type: Species
is: CHEBI:50211
boundary condition: false
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3

metaM fmn c
initial concentration: 1.0
name: FMN
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
initial amount: NaN
is: CHEBI:58210
is: C00061
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB01520
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_5472f2b3_61fd_47b0_9a69_bcccc0a45a96
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
name: MGLL
initial concentration: NaN
is: SBO:0000252
is: B2ZGL7
type: Species
is encoded by: hsa:11343

metaR r0281
is version of: http://identifiers.org/ec-code/5.3.1.6
is described by: ECO:0000000
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
modifier: MODEL1310110003#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:

metaR MANtg
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110003#
type: Reaction
name: mannose efflux from Golgi apparatus
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110003#
reversible: false
product: MODEL1310110003#

metaR RE3626M
fast: false
kinetic law: MODEL1310110003#
is: SBO:0000176
type: Reaction
reversible: false
name: RE3626
is version of: http://identifiers.org/ec-code/1.3.3.6
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110003#

metaR VALTA
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
name: valine transaminase
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000269
reversible: true

metaR ACt2m
kinetic law: MODEL1310110003#
name: acetate mitochondrial transport via proton symport
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
product: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
is: SBO:0000185

metaR 3MOBt2im
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
type: Reaction
reversible: false
is described by: ECO:0000000
is: SBO:0000185
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM

metaR P450SCC1m
product: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
type: Reaction
fast: false
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
name: cholesterol monooxygenase
reactant: MODEL1310110003#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_0afe177d_3b3a_4767_82ce_334d05928538
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
name: GPX1
initial amount: NaN
is encoded by: hsa:2876
boundary condition: true
constant: false

metaR q10tm
fast: false
is described by: ECO:0000134
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
name: transport of ubiquinone into mitochondria
type: Reaction
kinetic law: MODEL1310110003#

metaR r2117
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM odecoa r
initial concentration: 1.0
type: Species
is: CHEBI:57387
constant: false
name: oleoyl-CoA(4-)
has only substance units: false
initial amount: NaN
is: HMDB01322
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,26-28,32-34,38,49-50H,4-10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-/t28-,32-,33-,34+,38-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
boundary condition: false
is: SBO:0000247

metaR GTHP
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.11.1.15
type: Reaction
name: glutathione peroxidase
kinetic law: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/1.11.1.9
product: MODEL1310110003#
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.12
is described by: ECO:0000134
modifier: MODEL1310110003#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_416d784b_f2e4_4d9f_92f7_ed251a8ece50
has only substance units: false
constant: false
is: SBO:0000252
type: Species
name: IDI1
boundary condition: true
initial concentration: NaN
is: Q13907
is encoded by: hsa:3422
initial amount: NaN

metaM udpg e
is: CHEBI:58367
initial amount: NaN
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
initial concentration: 1.0
is: SBO:0000247
is: HMDB00286
boundary condition: false
has only substance units: false
type: Species
constant: false

metaR r0747
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000176
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific); 3alpha,7alpha-Dihydroxy-5beta-cholestane:NADP+ oxidoreductase Bile acid biosynthesis EC:1.1.1.50
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:1554355,PMID:1591235,PMID:3459552 NOTES:
type: Reaction
fast: false
product: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_9098334c_d0b8_4531_b315_5062947b9375
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is: Q6IA69
constant: false
name: NADSYN1
initial amount: NaN
is encoded by: hsa:55191

metaR NMNATr
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110003#
name: nicotinamide-nucleotide adenylyltransferase
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.1

http://identifiers.org/biomodels.db/MODEL1310110003#_1550386e_ff72_4c13_9d32_c5ba35223279
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: P18283
boundary condition: true
is encoded by: hsa:2877
name: GPX2
is: SBO:0000252
initial amount: NaN

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

metaR O2Stx
is: SBO:0000185
reactant: MODEL1310110003#
fast: false
type: Reaction
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
reversible: true
is described by: ECO:0000000
name: superoxide anion transport via diffusion (peroxisome)
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_091abae4_41f0_4c6b_a2e7_df97ddf7bba4
has only substance units: false
type: Species
is encoded by: hsa:R33828
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: _R33828_1_c
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_6e789338_3d63_4ecc_9532_5cfc1a3ddd6b
name: SLC25A10
is: Q9UBX3
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1468
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_0b6f1c9f_4c72_42b3_b7cd_cd3919a62ba6
boundary condition: true
is: P17050
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: NAGA
type: Species
has only substance units: false
is encoded by: hsa:4668

metaM akg m
is: CHEBI:16810
type: Species
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
boundary condition: false
initial concentration: 1.0
is: HMDB00208
is: SBO:0000247
name: 2-Oxoglutarate
has only substance units: false
is: C00026
constant: false
initial amount: NaN

metaR PIter
name: phosphate transport, endoplasmic reticulum
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
is described by: ECO:0000212
modifier: MODEL1310110003#
fast: false
product: MODEL1310110003#

metaR CYTK10
fast: false
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110003#
kinetic law: MODEL1310110003#
name: cytidylate kinase (CMP,dGTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110003#
is: SBO:0000176
reversible: true

metaM dhf e
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial concentration: 1.0
type: Species
name: dihydrofolate(2-)
has only substance units: false
is: SBO:0000247
is: HMDB01056
constant: false
boundary condition: false
is: CHEBI:57451
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_df3c3002_b980_422b_9d3c_ff6b77704eb9
is: Q6FG42
name: NDUFA7
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:4701
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR ACt2r
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false
is described by: ECO:0000000
reversible: true
name: acetate reversible transport via proton symport
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
reactant: MODEL1310110003#

metaM ha pre1 l
initial concentration: 1.0
has only substance units: false
name: hyaluronan biosynthesis, precursor 1
boundary condition: false
initial amount: NaN
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
is: SBO:0000247
is: CHEBI:16126
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_a29a5f35_8869_4d4c_954d_a12b48051f64
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
name: LHPP
is: Q9H008
is encoded by: hsa:64077
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_76c99988_f09e_4643_ab86_f95af39ef9e3
is: O43677
has only substance units: false
is encoded by: hsa:4717
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
name: NDUFC1

metaR HS2ly
is: SBO:0000176
name: heparan-N-sulfatase, lysosomal
fast: false
reversible: false
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.10.1.1
kinetic law: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
product: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction

metaM sbt D e
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
initial concentration: 1.0
is: HMDB00247
type: Species
name: D-glucitol
constant: false
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM HC01444 e
is: CHEBI:15754
type: Species
is: SBO:0000247
boundary condition: false
name: Galactosylglycerol
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401

metaR ACNACNGALGBSIDEte
type: Reaction
name: acnacngalgbside hs transport
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reversible: true
fast: false
product: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
reactant: MODEL1310110003#

metaR 4MOPt2im
is described by: ECO:0000000
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
name: 4-methyl-2-oxopentanoate mitochondrial transport via proton symport
is: SBO:0000185
reversible: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_616440e7_3d0b_42c2_81fe_d5754c0cbffd
is: Q15392
boundary condition: true
initial amount: NaN
name: DHCR24
type: Species
has only substance units: false
is encoded by: hsa:1718
initial concentration: NaN
constant: false
is: SBO:0000252

metaR EX malt LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_7ebcbb18_08b4_40a0_92b6_b53cf658c617
initial concentration: NaN
type: Species
is encoded by: hsa:1345
constant: false
is: SBO:0000252
name: COX6C
initial amount: NaN
boundary condition: true
is: P09669
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_3cb9cd86_1469_4e96_b9cd_2d4991a6ee7f
is encoded by: hsa:2643
has only substance units: false
is: SBO:0000252
constant: false
is: Q8IZH9
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: GCH1
type: Species

metaR r0055
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.2.7
reversible: true
fast: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.2.8
type: Reaction
is: SBO:0000176
is described by: ECO:0000000

metaM gluside hs r
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false
initial amount: NaN
is: CHEBI:18368
name: D-glucosyl-N-acylsphingosine

metaR r1573
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_7c86cac8_4373_4932_807e_81b5108e436e
initial concentration: NaN
is encoded by: hsa:6550
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: SLC9A3
is: SBO:0000252
is: P48764

metaR CHSTEROLt3
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110003#
reversible: true
product: MODEL1310110003#
fast: false
type: Reaction
kinetic law: MODEL1310110003#
name: cholesterol intracellular transport
is described by: ECO:0000000

metaM sphs1p r
is: HMDB00277
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: SBO:0000247
has only substance units: false
name: sphingosine 1-phosphate(1-)
constant: false
initial concentration: 1.0
is: CHEBI:60119

metaR TYROXDAc
is: SBO:0000176
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
reversible: false
product: MODEL1310110003#
is described by: ECO:0000269
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.4.3.4
fast: false

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_a2f1d6dd_9b80_49e4_b37b_fb266679f9bb
name: _NM_001929_1_c
is encoded by: hsa:NM 001929
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_9adf99c7_ac14_44dc_8486_e53818961eb7
is encoded by: hsa:54995
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: Q9NWU1
name: OXSM

http://identifiers.org/biomodels.db/MODEL1310110003#_e9cf6c0f_b0cf_481d_b958_1dfd4f9901e3
initial amount: NaN
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: ACOX1
is: B4DK61
is encoded by: hsa:51
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_586df858_116c_4276_8715_66c11f676349
is: E7EPT3
constant: false
is encoded by: hsa:501
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
name: ALDH7A1
type: Species

metaR ACCOAtn
kinetic law: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110003#
name: acetyl-CoA transport, nuclear

metaR CYANtm
is: SBO:0000185
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:assumed to be readily diffusible MM
reactant: MODEL1310110003#
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
name: Cyanide transport via diffusion (mitochondrial)
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_fab17b7f_4fd7_45a3_a370_7a69f66345d7
has only substance units: false
name: DGKH
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:160851
type: Species
is: A8K0I1

metaM gdp g
is: HMDB01201
constant: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:58189
name: GDP(3-)
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM pi m
is: CHEBI:43474
initial concentration: 1.0
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
is: C00009
constant: false
has only substance units: false
is: HMDB00973
type: Species
initial amount: NaN
boundary condition: false
name: hydrogenphosphate

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_243127b3_468b_443d_bd60_e9cbe9d323b8
type: Species
is: Q96EK6
boundary condition: true
initial amount: NaN
is encoded by: hsa:64841
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
name: GNPNAT1

metaR HIBDm
product: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
fast: false
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.31
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110003#_4353f8dd_940c_4bd6_97e4_289d8b835a73
boundary condition: true
initial concentration: NaN
name: HK1
is encoded by: hsa:3098
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
is: B3KXY9
type: Species

metaM 3hmp m
is: SBO:0000247
type: Species
is: HMDB00023
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:11805
name: 3-hydroxy-2-methylpropanoate
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188

metaR BAAT1x
type: Reaction
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 4 AUTHORS: NOTES:glycine or taurine as substrates, produces glycocholic or taurocholic acids respectively NJ
fast: false
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
name: bile acid Coenzyme A: amino acid N-acyltransferase
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176

metaR r1570
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_960b0a03_0ee8_4167_8759_28518798f59c
name: DLAT:DLD:PDHA1:PDHB:PDHX
type: Species
constant: false
is encoded by: hsa:5160
boundary condition: true
is: SBO:0000297
initial concentration: NaN
has only substance units: false
initial amount: NaN
has part: P08559

metaM dgsn c
is: SBO:0000247
constant: false
is: C00330
name: Deoxyguanosine
type: Species
is: CHEBI:17172
boundary condition: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
has only substance units: false
is: HMDB00085
initial amount: NaN
initial concentration: 1.0

metaM dutp m
is: HMDB01191
initial amount: NaN
name: dUTP
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:17625
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false

metaR CYTK7n
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (CMP,UTP),nuclear
is: SBO:0000176
type: Reaction
modifier: MODEL1310110003#
product: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#

metaR r0744
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 4.2.1.107 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
reactant: MODEL1310110003#
is: SBO:0000176
name: (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl- CoA hydro-lyase Bile acid biosynthesis EC:4.2.1.107
reversible: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_37fa59a9_6f13_496e_824a_0378ec2bb019
is: Q6FGV9
is encoded by: hsa:10654
constant: false
has only substance units: false
boundary condition: true
type: Species
name: PMVK
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR ACETONEt2
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
name: acetone transport via proton symport
product: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000269
fast: false
reactant: MODEL1310110003#
reversible: true
type: Reaction
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#

metaM sbt D c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: D-glucitol
type: Species
is: HMDB00247
is: CHEBI:17924
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1

metaR XOLDIOLONEt
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
type: Reaction

metaR r1571
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
fast: false
is: SBO:0000185
kinetic law: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaR EX hspg LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heparan sulfate proteoglycan exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_ae42f6f6_a7db_478f_8c07_b575227c7542
name: ACSL5
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is: Q9ULC5
initial amount: NaN
is encoded by: hsa:51703
initial concentration: NaN
boundary condition: true

metaR G14T16g
kinetic law: MODEL1310110003#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
modifier: MODEL1310110003#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_a5ac3fd0_7f16_4c11_a473_6927a3561165
constant: false
is: O95954
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:10841
name: FTCD

metaM dutp n
has only substance units: false
name: dUTP
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17625
is: HMDB01191
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
type: Species

metaR ACALDt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110003#
name: acetaldehyde reversible transport
reversible: true
fast: false
product: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#

metaR EX dhdascb LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dehydroascorbide(1-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_8ce976cf_4665_443f_8bde_0d5ec83251ad
is: SBO:0000252
name: DAD1
is: Q53G02
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:1603

http://identifiers.org/biomodels.db/MODEL1310110003#_be28489b_66ad_4eaf_b484_344e1e7143b5
is: Q9HBH5
is encoded by: hsa:57665
initial amount: NaN
type: Species
initial concentration: NaN
name: RDH14
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false

metaR RE1523M
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
type: Reaction
name: RE1523

metaM acnam n
is: CHEBI:35418
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: N-acetylneuraminate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
constant: false
is: HMDB00230

metaR r0743
name: hydroxysteroid (17-beta) dehydrogenase 4 Bile acid biosynthesis EC:1.1.1.35
is described by: ECO:0000000
product: MODEL1310110003#
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11330072 NOTES:
type: Reaction
modifier: MODEL1310110003#

metaM pe hs c
is: CHEBI:16038
boundary condition: false
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0
name: phosphatidylethanolamine
initial concentration: 1.0

metaM so3 c
initial concentration: 1.0
boundary condition: false
name: Sulfite
is: CHEBI:17137
type: Species
is: HMDB00240
constant: false
is: SBO:0000247
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: C00094
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_1b76f23e_0ae9_490f_9d06_0554159481bb
is encoded by: hsa:125965
initial amount: NaN
boundary condition: true
name: COX6B2
initial concentration: NaN
is: SBO:0000252
is: Q6YFQ2
type: Species
constant: false
has only substance units: false

metaM bhb e
has only substance units: false
is: HMDB00011
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
type: Species
name: (R)-3-hydroxybutyrate
initial concentration: 1.0
is: CHEBI:10983
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089

http://identifiers.org/biomodels.db/MODEL1310110003#_0d8a89dc_e619_4be3_af1d_9024951ba71e
boundary condition: true
constant: false
is: O95395
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:9245
initial concentration: NaN
name: GCNT3
initial amount: NaN

metaR CYTK14
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,UTP)
type: Reaction
kinetic law: MODEL1310110003#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110003#
is: SBO:0000176
modifier: MODEL1310110003#

metaM succoa m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
boundary condition: false
is: HMDB01022
name: Succinyl-CoA
is: SBO:0000247
constant: false
is: CHEBI:57292
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_ca5fef04_8ea2_4806_a977_94e8acd9d577
type: Species
constant: false
is: P56556
name: NDUFA6
initial amount: NaN
is encoded by: hsa:4700
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR UAG4E
fast: false
type: Reaction
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110003#
reactant: MODEL1310110003#
name: UDP-N-acetylglucosamine 4-epimerase
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/5.1.3.2
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_09d89fb8_8f0e_40c0_937d_536ad6356f23
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
name: SLC26A6
is: Q9NQU1
type: Species
initial amount: NaN
is encoded by: hsa:65010
is: SBO:0000252

metaR ARACHCRNt
is: SBO:0000185
kinetic law: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
product: MODEL1310110003#
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000
fast: false
reversible: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR UDPGLCter
kinetic law: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
reactant: MODEL1310110003#
fast: false
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
is: SBO:0000185
reversible: true

metaR r1576
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_fbdba1cd_9968_448a_979d_496b0d8f50bd
initial concentration: NaN
is: Q6GTM5
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6309
initial amount: NaN
constant: false
boundary condition: true
type: Species
name: SC5DL

metaR UDPtl
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
reversible: true
kinetic law: MODEL1310110003#
name: udp intracellular transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_d2887062_2b44_43e9_8ad1_51557f0c1488
is: Q96KJ9
is encoded by: hsa:84701
has only substance units: false
type: Species
initial concentration: NaN
name: COX4I2
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_8c8f7732_22fe_4812_baf6_d7f2213ed9f9
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: PANK2
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:80025

http://identifiers.org/biomodels.db/MODEL1310110003#_e06dd74a_d74e_443e_94e2_291af766883f
is: SBO:0000252
constant: false
is: P15531
name: NME1
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4830
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_5316f026_570c_4a59_b1ee_c1df73afed99
boundary condition: true
is encoded by: hsa:4708
is: SBO:0000252
name: NDUFB2
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: H7C5B8
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_3c6b4766_16d4_41b0_8abf_c55af956bb27
initial amount: NaN
is: SBO:0000252
name: GGT2
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:728441
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_46b0e780_9996_4131_b4e4_2f9848c4b9a6
is: Q99519
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:4758
name: NEU1
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR GASNASE2ly
type: Reaction
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.5.1.26
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000176
name: glycosylasparaginase, lysosomal
reversible: false
product: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false

metaM HC02172 c
boundary condition: false
name: Zinc
notes: FORMULA: Zn CHARGE: 2 INCHI: InChI=1S/Zn/q+2
is: CHEBI:29105
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR r0051
fast: false
is described by: ECO:0000000
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
product: MODEL1310110003#
kinetic law: MODEL1310110003#
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
reactant: MODEL1310110003#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
is: SBO:0000176

metaR CYTK13
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
fast: false
name: cytidylate kinase (dCMP,dATP)
reactant: MODEL1310110003#
is described by: ECO:0000269

metaM Rtotal3 e
is: CHEBI:3554
initial amount: NaN
is: C00255
name: R total 3 position
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: HMDB00244
has only substance units: false
is: SBO:0000247
notes: FORMULA: CO2FULLR3 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110003#_6b987b7f_7f56_4870_b7bf_849b9f092486
constant: false
is encoded by: hsa:6584
is: O76082
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: SLC22A5

metaM xylt c
boundary condition: false
initial amount: NaN
name: xylitol
initial concentration: 1.0
constant: false
is: CHEBI:17151
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
has only substance units: false
is: HMDB02917
is: SBO:0000247

metaM q10h2 m
boundary condition: false
constant: false
type: Species
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
has only substance units: false
is: HMDB13111
name: Ubiquinol-10
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6504740
is: SBO:0000247

metaM pi n
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
is: SBO:0000247
is: CHEBI:43474
name: hydrogenphosphate
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB00973

http://identifiers.org/biomodels.db/MODEL1310110003#_b2077daf_82dc_4b66_8bac_ffe6d84fdfe8
has only substance units: false
name: SLC23A2
initial concentration: NaN
initial amount: NaN
type: Species
is: Q9UGH3
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9962
constant: false

metaR PACCOAL
name: phenylacetate-CoA ligase
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 6.2.1.30 Confidence Level: 2 AUTHORS: NOTES:JLR
product: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110003#

metaR RE1448N
name: RE1448
fast: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 0 AUTHORS: PMID:7556092,PMID:9367831 NOTES:

metaR DNDPt35m
is described by: ECO:0000269
fast: false
name: dGDP transport via dADP antiport
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
is: SBO:0000185
reversible: false
modifier: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaM triodthy c
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
constant: false
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00265
boundary condition: false
name: 3,3',5-triiodo-L-thyronine
is: CHEBI:18258
initial concentration: 1.0

metaR DURIPP
reactant: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
name: deoxyuridine phosphorylase
is version of: http://identifiers.org/ec-code/2.4.2.1
is version of: http://identifiers.org/ec-code/2.4.2.3
fast: false
is described by: ECO:0000269
reversible: true

metaR RE0958E
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
name: RE0958
type: Reaction
product: MODEL1310110003#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110003#

metaR FRDPtcr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
is described by: ECO:0000134
is: SBO:0000185
fast: false
kinetic law: MODEL1310110003#
type: Reaction
reversible: true
product: MODEL1310110003#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
reactant: MODEL1310110003#

metaM udpg c
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
is: C00029
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:58367
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: UDPglucose
has only substance units: false
is: HMDB00286

http://identifiers.org/biomodels.db/MODEL1310110003#_9d1ff9e5_ce23_419a_9303_43f97615735a
is: SBO:0000252
boundary condition: true
name: HAS2
type: Species
is encoded by: hsa:3037
is: Q92819
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN

metaM 4mop m
type: Species
is: SBO:0000247
is: HMDB00695
initial amount: NaN
boundary condition: false
name: 4-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: CHEBI:17865
initial concentration: 1.0
has only substance units: false
constant: false

metaM pe hs e
is: CHEBI:16038
initial concentration: 1.0
name: phosphatidylethanolamine
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
type: Species
has only substance units: false

metaM bhb c
constant: false
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
type: Species
is: HMDB00011
has only substance units: false
is: CHEBI:10983
initial amount: NaN
name: (R)-3-hydroxybutyrate
boundary condition: false
initial concentration: 1.0

metaR CYTK13n
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
product: MODEL1310110003#
name: cytidylate kinase (dCMP,dATP),nuclear
reactant: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#

metaR CHSTEROLt2
fast: false
name: cholesterol intracellular transport
kinetic law: MODEL1310110003#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
is: SBO:0000185

metaM dhf c
initial amount: NaN
is: CHEBI:57451
name: 7,8-Dihydrofolate
has only substance units: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB01056
is: C00415
constant: false
initial concentration: 1.0

metaM pyr x
name: pyruvate
is: C00022
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/3324
is: HMDB00243
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: SBO:0000247
is: CHEBI:15361

metaR r0741
modifier: MODEL1310110003#
name: 5beta-Cholestane-3alpha,7alpha,12alpha-triol,NADPH:oxygen oxidoreductase (26-hydroxylating) Bile acid biosynthesis EC:1.14.13.15
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.15 Confidence Level: 0 AUTHORS: PMID:1591235,PMID:271969,PMID:4026854,PMID:7077149 NOTES:IT - HepatoNet mapping of HC01455 to dhochoylcoa was wrong, xoltetrol is correct mapping. Therefore, r0742 is identical to P45027A11m and r0741 is cytosol version of P45027A11m
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
reversible: true

metaR AG13T14g
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
type: Reaction
modifier: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR EX glysar LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylsarcosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_438ace42_f822_4c08_87bf_0a6d52277148
initial concentration: NaN
is: Q1EHB4
initial amount: NaN
name: SLC5A12
is: SBO:0000252
has only substance units: false
is encoded by: hsa:159963
boundary condition: true
type: Species
constant: false

metaR CYTK12
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110003#
fast: false
reversible: true
type: Reaction
modifier: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000269
is: SBO:0000176
name: cytidylate kinase (dCMP,dCTP)

metaR ADK1m
kinetic law: MODEL1310110003#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD
product: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
name: adenylate kinase, mitochondrial
modifier: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3

metaM dcdp m
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
name: dCDP(3-)
is: CHEBI:58593
is: SBO:0000247
is: HMDB01245
type: Species
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR r1574
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_38c5713e_6cca_4650_9ebc_df443b9dd6a1
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6524
type: Species
constant: false
has only substance units: false
is: P31639
initial concentration: NaN
name: SLC5A2

metaR GRTTx
name: geranyltranstransferase
reversible: false
fast: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.10 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
kinetic law: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.1
is described by: ECO:0000134

metaM rnam c
notes: FORMULA: C11H15N2O5 CHARGE: 1 INCHI: InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1 EHMN_ABBREVIATION: C03150
is: SBO:0000247
type: Species
is: CHEBI:15927
has only substance units: false
name: N-Ribosylnicotinamide
constant: false
is: HMDB00855
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR r0809
reversible: true
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1550832,PMID:8438778 NOTES:
is: SBO:0000185
reactant: MODEL1310110003#
type: Reaction
name: Facilitated diffusion
is described by: ECO:0000000
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.85
modifier: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#

metaM ditp n
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
name: dITP(4-)
initial amount: NaN
type: Species
is: HMDB03537
is: CHEBI:61382

metaM HC02172 e
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
name: Zinc
boundary condition: false
is: CHEBI:29105
notes: FORMULA: Zn CHARGE: 2 INCHI: InChI=1S/Zn/q+2
constant: false
initial concentration: 1.0

metaM hs deg23 l
type: Species
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
constant: false
notes: FORMULA: C31H49NO29S CHARGE: -2
boundary condition: false
is: CHEBI:21338
initial amount: NaN
initial concentration: 1.0
is: HMDB02704
is: SBO:0000247
has only substance units: false

metaR EX pchol hs LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Phosphatidylcholine (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_2fed46d2_c01f_46f1_87d8_92fb83d8ed28
initial amount: NaN
is: Q9NPB1
constant: false
has only substance units: false
type: Species
is encoded by: hsa:56953
initial concentration: NaN
name: NT5M
is: SBO:0000252
boundary condition: true

metaR CYTK11
reactant: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
name: cytidylate kinase (dCMP,dGTP)
is described by: ECO:0000269
product: MODEL1310110003#
is: SBO:0000176
modifier: MODEL1310110003#

metaM dcdp n
name: dCDP(3-)
is: CHEBI:58593
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01245
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705

metaR CHSTEROLt1
reactant: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000304
type: Reaction
name: cholesterol intracellular transport
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (10948.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12070139,PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ. NS: transport from lysozyme to mitochondria?
kinetic law: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
fast: false

metaM Rtotal3 c
is: SBO:0000247
is: CHEBI:16189
name: R total 3 position
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: CO2FULLR3 CHARGE: -1
is: HMDB01448

http://identifiers.org/biomodels.db/MODEL1310110003#_f91ca911_5174_4ad0_bb83_af6cd99e4cef
constant: false
is: SBO:0000252
is: Q9NPH0
name: ACP6
boundary condition: true
is encoded by: hsa:51205
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species

metaM acgam r
type: Species
is: CHEBI:17411
name: N-acetyl-D-glucosamine
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: HMDB00215
initial amount: NaN
has only substance units: false

metaR r1575
is: SBO:0000185
reactant: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110003#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_997da0b8_2614_4600_ae7d_597def771872
initial amount: NaN
is: Q9H6Y6
has only substance units: false
name: MYO5B
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:4645
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_0e7f44d9_e482_4646_a22b_0848aa859b9b
is encoded by: hsa:50484
type: Species
is: SBO:0000252
is: Q7LG56
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: RRM2B
initial concentration: NaN

metaR r1467
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
name: Postulated transport reaction
kinetic law: MODEL1310110003#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110003#
fast: false
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_afed44dd_b94d_4acc_87a9_6fd8be05b6d5
is encoded by: hsa:349565
is: Q96T66
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
name: NMNAT3
is: SBO:0000252
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_58515252_535e_424d_a2f2_8658dbbafd09
is encoded by: hsa:10195
is: Q92685
has only substance units: false
boundary condition: true
is: SBO:0000252
name: ALG3
initial amount: NaN
initial concentration: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_bacf3e42_5672_4c0a_8934_d847039fdc9e
initial amount: NaN
is: A0S0A7
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
name: NOS3
is encoded by: hsa:4846
initial concentration: NaN
constant: false

metaM akg e
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 2-oxoglutarate(2-)
type: Species
is: CHEBI:16810
initial concentration: 1.0
is: HMDB00208
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
boundary condition: false

metaR AG13T7g
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000

metaM andrstrn r
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB00031
is: CHEBI:16032
name: androsterone

metaR r2521
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
name: Utilized transport
is described by: ECO:0000000
kinetic law: MODEL1310110003#
fast: false

metaM glu5sa m
is: HMDB02104
is: SBO:0000247
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
name: L-Glutamate 5-semialdehyde
initial concentration: 1.0
initial amount: NaN
constant: false
is: C01165
has only substance units: false
type: Species
is: CHEBI:17232
boundary condition: false

metaM pi c
name: hydrogenphosphate
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00973
notes: FORMULA: HO4P CHARGE: -2
is: CHEBI:43474
has only substance units: false
is: C00009
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_15d52058_9189_4e69_81c4_4b07e67cfc0d
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:84889
boundary condition: true
is: Q8WY07
initial amount: NaN
name: SLC7A3
constant: false

metaM Lcystin c
is: CHEBI:16283
initial concentration: 1.0
type: Species
is: HMDB00192
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: L-cystine
constant: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1

metaM 5dpmev c
is: HMDB01090
is: SBO:0000247
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1
constant: false
boundary condition: false
initial amount: NaN
name: (R)-5-Diphosphomevalonate
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_c1e751c0_d0f2_4069_afda_f3f49326ebb7
is encoded by: hsa:1716
initial concentration: NaN
is: E5KSL6
boundary condition: true
name: DGUOK
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaM spmd c
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
boundary condition: false
name: Spermidine
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:57834
type: Species
is: C00315
is: HMDB01257
initial concentration: 1.0

metaR DURAD
is version of: http://identifiers.org/ec-code/1.3.1.2
reversible: true
reactant: MODEL1310110003#
name: dihydrouracil dehydrogenase (NADP)
product: MODEL1310110003#
fast: false
type: Reaction
modifier: MODEL1310110003#
is described by: ECO:0000269
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is: SBO:0000176

metaR r2520
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110003#
fast: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#

metaM imp c
initial concentration: 1.0
name: IMP
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
is: CHEBI:58053
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: HMDB00175
constant: false
boundary condition: false
is: C00130

metaM chito2pdol U c
is: SBO:0000247
is: CHEBI:12427
boundary condition: false
constant: false
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaM asp L e
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: HMDB00191
type: Species
is: CHEBI:29991
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
name: L-aspartate(1-)

metaM ins e
initial amount: NaN
is: C00294
is: CHEBI:17596
boundary condition: false
name: Inosine
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
is: HMDB00195
has only substance units: false

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR NDPK4n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000304
reversible: true
fast: false
reactant: MODEL1310110003#

metaM hs deg12 l
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:15699
is: SBO:0000247
name: heparan sulfate, degradation product 12
is: HMDB00719
boundary condition: false
initial amount: NaN
notes: FORMULA: C55H82N3O64S6 CHARGE: -7
type: Species

metaM prpncoa m
initial concentration: 1.0
is: CHEBI:57367
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
constant: false
has only substance units: false
name: acryloyl-CoA(4-)
is: HMDB02307
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894

metaM r5p c
is: C00117
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
constant: false
is: CHEBI:18189
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: alpha-D-Ribose 5-phosphate
type: Species
is: HMDB00618

http://identifiers.org/biomodels.db/MODEL1310110003#_e762236e_5f4d_428a_b644_29896a9dae00
constant: false
has only substance units: false
type: Species
is encoded by: hsa:203
name: AK1
is: P00568
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_6763eab2_65a0_46d0_876f_4834d596109b
has only substance units: false
is encoded by: hsa:6487
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: ST3GAL3

http://identifiers.org/biomodels.db/MODEL1310110003#_11856db1_ac37_47af_bd17_04cf0d44a84f
is: SBO:0000252
name: PECR
is encoded by: hsa:55825
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q9BY49
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_87962f28_50f6_4e49_aa7b_c484bb33bc79
name: _286297_1_c
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:286297
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species

metaR CH25H
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
name: cholesterol 25-hydroxylase
fast: false
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.14.99.38
reversible: false
product: MODEL1310110003#

metaM citr L m
initial amount: NaN
is: SBO:0000247
is: CHEBI:16349
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00904
name: L-citrulline
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
has only substance units: false
constant: false

metaM ditp c
initial concentration: 1.0
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: dITP(4-)
is: HMDB03537
has only substance units: false
constant: false
is: CHEBI:61382

metaM CE2433 m
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
boundary condition: false
is: CHEBI:57795
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
constant: false
type: Species

metaM pi e
type: Species
name: hydrogenphosphate
initial concentration: 1.0
is: HMDB00973
is: C00009
is: CHEBI:43474
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247

metaR ALDD2xm
is described by: ECO:0000134
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
kinetic law: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
modifier: MODEL1310110003#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110003#

metaR r0009
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.1
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
modifier: MODEL1310110003#
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
product: MODEL1310110003#
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110003#

metaR RE0915E
product: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
name: RE0915
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.2.1.17
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1

http://identifiers.org/biomodels.db/MODEL1310110003#_9898de39_d5a1_4b74_b1aa_b47b5fa0c28b
constant: false
boundary condition: true
initial amount: NaN
name: RDH12
is: SBO:0000252
is: Q96NR8
is encoded by: hsa:145226
initial concentration: NaN
type: Species
has only substance units: false

metaR CMPACNAtg
product: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
name: CMP-Sia Golgi transport via CMP antiport
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_297a91ef_9915_45a2_a644_c9b7a1ed34a6
initial concentration: NaN
name: ACO2
boundary condition: true
is: Q99798
constant: false
is encoded by: hsa:50
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_a5518cea_0217_45fe_837d_82cbc2b26285
is: SBO:0000252
is: P31350
type: Species
has only substance units: false
name: RRM2
is encoded by: hsa:6241
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR r1466
fast: false
reactant: MODEL1310110003#
name: EC:2.3.1.86
is: SBO:0000176
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110003#

metaM xylt e
has only substance units: false
is: CHEBI:17151
name: xylitol
initial amount: NaN
is: HMDB02917
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_69c17d91_a0a9_4e12_93a7_3d7c4851082a
is encoded by: hsa:956
name: ENTPD3
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: O75355
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_a143769f_5d1f_45ca_9028_6e9082dd5a73
initial amount: NaN
is encoded by: hsa:AI697028
constant: false
type: Species
boundary condition: true
name: _AI697028_1_m
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_670c1635_e4a3_4406_9b98_bfde70464306
is: SBO:0000252
name: NDUFA3
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:4696
is: O95167
initial amount: NaN
has only substance units: false
type: Species

metaM spmd e
has only substance units: false
initial concentration: 1.0
is: C00315
boundary condition: false
is: HMDB01257
is: CHEBI:57834
type: Species
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
name: Spermidine
initial amount: NaN
is: SBO:0000247
constant: false

metaR r0680
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.137
product: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaR SUCCt4 2
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
name: succinate transport via sodium symport
fast: false
product: MODEL1310110003#

metaM asp L c
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:29991
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: HMDB00191
boundary condition: false
name: L-aspartate(1-)

metaR EX ile L LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Isoleucine exchange
type: Reaction

metaM pro D c
initial concentration: 1.0
name: D-proline
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:16313
is: SBO:0000247
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
constant: false
is: HMDB03411

metaR DGK2m
reactant: MODEL1310110003#
reversible: true
fast: false
is: SBO:0000176
kinetic law: MODEL1310110003#
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
product: MODEL1310110003#

metaM ins c
is: HMDB00195
is: C00294
boundary condition: false
name: Inosine
initial amount: NaN
is: CHEBI:17596
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_f9b64323_b387_4006_95ea_ffeb18131701
initial concentration: NaN
is: Q674R7
initial amount: NaN
has only substance units: false
name: ATG9B
type: Species
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:285973

metaM C05280 m
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,11-12,20-22,26-28,32,43-44H,4-7,10,13-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,12-11-/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05280
name: cis,cis-3,6-Dodecadienoyl-CoA
initial amount: NaN
is: CHEBI:28002
is: SBO:0000247
is: HMDB03952
type: Species
initial concentration: 1.0
boundary condition: false
constant: false

metaR BETALDHxm
type: Reaction
reversible: false
product: MODEL1310110003#
name: betaine-aldehyde dehydrogenase, mitochondrial
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_16d9534b_d9a6_4385_90f6_4ed8df596b03
is: Q3KQV9
name: UAP1L1
boundary condition: true
is encoded by: hsa:91373
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
constant: false

metaR 34DHPHEt
type: Reaction
fast: false
name: 3,4-Dihydroxy-L-phenylalanine transport
is: SBO:0000185
is described by: ECO:0000269
product: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:NCD

metaM dgsn e
is: C00330
name: Deoxyguanosine
is: CHEBI:17172
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: HMDB00085
has only substance units: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330

metaR AKR1D2
fast: false
is: SBO:0000176
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000269
product: MODEL1310110003#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
is version of: http://identifiers.org/ec-code/1.3.1.3
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_f3250c1a_897b_4ed5_a110_621025a417be
initial amount: NaN
type: Species
has only substance units: false
is: P51648
initial concentration: NaN
name: ALDH3A2
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:224

metaM g6p r
initial amount: NaN
boundary condition: false
is: C00092
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:61548
name: D-Glucose 6-phosphate
type: Species
constant: false
is: HMDB01401
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_7fdbc850_750e_46e0_bde6_5a63c7060d41
has only substance units: false
is: SBO:0000252
name: _AI620219_1_m
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:AI620219
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_eb7524e5_e011_40f7_85d0_9600c523086c
constant: false
is encoded by: hsa:1635
has only substance units: false
is: SBO:0000252
is: P32321
type: Species
boundary condition: true
name: DCTD
initial concentration: NaN
initial amount: NaN

metaR OAGD3te
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
fast: false
is: SBO:0000185
name: oagd3 hs transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ

metaM pi g
constant: false
type: Species
is: CHEBI:43474
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00973
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009

metaM bhb m
initial amount: NaN
constant: false
is: CHEBI:10983
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00011

http://identifiers.org/biomodels.db/MODEL1310110003#_40cc3ef4_90e7_4e59_a66f_30d643f1a436
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:U37519
boundary condition: true
is: SBO:0000252
name: _U37519_1_m
constant: false
initial concentration: NaN

metaR r1925
modifier: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110003#
fast: false
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_3bbfa486_3802_44ca_a370_9a8b0cc0eefd
initial concentration: NaN
initial amount: NaN
is: P05062
is encoded by: hsa:229
boundary condition: true
constant: false
type: Species
has only substance units: false
name: ALDOB
is: SBO:0000252

metaR ACACt2m
modifier: MODEL1310110003#
reversible: true
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD
fast: false
reactant: MODEL1310110003#
name: Acetoacetate mitochondrial transport via H+ symport
is: SBO:0000185
product: MODEL1310110003#
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_246092a6_73c5_4392_a333_0f8059bd114f
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:3425
is: SBO:0000252
is: P35475
name: IDUA
type: Species
initial concentration: NaN
initial amount: NaN

metaM q10h2 e
name: Ubiquinol-10
constant: false
type: Species
is: SBO:0000247
is: HMDB13111
boundary condition: false
has only substance units: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/6504740
initial amount: NaN

metaR RIBt
product: MODEL1310110003#
type: Reaction
fast: false
name: ribose transport via diffusion
kinetic law: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
is: SBO:0000185
reversible: true
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_eae37ba3_1a75_4d44_980e_c3647609eeab
is encoded by: hsa:570
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: BAAT
constant: false
initial amount: NaN
is: Q14032

metaR BPNT
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.3.7
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000269
reversible: false
name: 3',5'-bisphosphate nucleotidase
reactant: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#

metaM abt c
constant: false
is: CHEBI:18403
name: L-arabinitol
is: HMDB01851
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_b78883e5_5abc_4e69_8e07_d967b6538cbb
name: NDUFS5
type: Species
is encoded by: hsa:4725
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: Q6IBA0
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_29ecc746_be9e_4228_80cb_4c3b06286dfd
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:D29675
has only substance units: false
boundary condition: true
initial concentration: NaN
name: _D29675_1_e

http://identifiers.org/biomodels.db/MODEL1310110003#_a0fb4072_4c69_4dd1_90e5_31321b986b90
is encoded by: hsa:220
initial concentration: NaN
constant: false
is: P47895
type: Species
name: ALDH1A3
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false

metaR r1464
product: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
name: Active transport
type: Reaction
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
reversible: true
fast: false
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_7a9eb2f5_c027_4cee_8b5b_8d141832f517
name: DGUOK
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:1716
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false

metaM phe L e
is: CHEBI:17295
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00159
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
has only substance units: false
constant: false
name: L-phenylalanine

metaR GULNDer
kinetic law: MODEL1310110003#
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
type: Reaction
name: gulonate dehydrogenase, endoplasmic reticulum
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_882c3b5c_9573_4e98_b973_5082abf82206
initial concentration: NaN
type: Species
is encoded by: hsa:AI620219
is: SBO:0000252
boundary condition: true
name: _AI620219_1_c
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_22dbdf7e_4ea1_4c9a_b5db_90915769a99f
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: _NM_013421_1_e
constant: false
is encoded by: hsa:NM 013421
type: Species

metaM pro D e
type: Species
initial amount: NaN
initial concentration: 1.0
name: D-proline
has only substance units: false
boundary condition: false
is: CHEBI:16313
constant: false
is: HMDB03411
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
is: SBO:0000247

metaR PAPStg
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
is described by: ECO:0000269
fast: false
reversible: true
is: SBO:0000185
modifier: MODEL1310110003#
name: 3'-Phosphoadenylyl sufate Golgi transport
kinetic law: MODEL1310110003#

metaM dcdp c
type: Species
is: HMDB01245
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
name: dCDP
is: CHEBI:58593
boundary condition: false
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C00705
has only substance units: false
initial amount: NaN

metaR HSPGtly
reversible: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
name: heparan sulfate transport, extracellular to lysosome

metaM ksi pre13 g
is: SBO:0000247
is: HMDB00175
constant: false
name: keratan sulfate I biosynthesis, precursor 13
boundary condition: false
is: CHEBI:58053
is: C00130
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
type: Species
initial amount: NaN

metaR O2Stn
is described by: ECO:0000000
name: superoxide anion transport via diffusion (nucleus)
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110003#
is: SBO:0000185
type: Reaction
reversible: true
reactant: MODEL1310110003#
fast: false

metaM akg c
constant: false
is: SBO:0000247
initial amount: NaN
is: C00026
initial concentration: 1.0
boundary condition: false
is: HMDB00208
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species
is: CHEBI:16810
name: 2-Oxoglutarate
has only substance units: false

metaM ibcoa m
name: isobutyryl-CoA(4-)
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: HMDB01243
is: SBO:0000247
boundary condition: false
is: CHEBI:57338
has only substance units: false

metaM occoa c
is: HMDB01070
is: SBO:0000247
name: Octanoyl-CoA (n-C8:0CoA)
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:57386
boundary condition: false
is: C01944

metaM so3 m
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: CHEBI:17137
initial amount: NaN
name: hydrogensulfite
boundary condition: false
is: HMDB00240
is: SBO:0000247

metaM dlnlcgcoa r
type: Species
boundary condition: false
is: C03595
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
name: dihomo-gamma-linolenyl coenzyme A
initial amount: NaN
is: CHEBI:27979
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_bd711a2f_cfc5_476b_8728_97c34a80ea53
is: E5KNH5
name: NDUFV1
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:4723
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_819bef55_7e25_4428_9029_d3fb442b373a
initial concentration: NaN
name: CA4
initial amount: NaN
type: Species
is encoded by: hsa:762
boundary condition: true
is: SBO:0000252
constant: false
is: Q6FHI7
has only substance units: false

metaM gdp c
is: C00035
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:58189
initial concentration: 1.0
has only substance units: false
name: GDP
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_68679a6b_3ae1_406a_b7cf_ab17fb3d17d1
is encoded by: hsa:26290
name: GALNT8
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is: Q9NY28
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_90084695_9d97_4b51_b7a2_0c26138493de
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6582
constant: false
name: SLC22A2
type: Species

metaR URIt5le
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
is: SBO:0000185
name: uridine transport in via sodium symport (1:2)
modifier: MODEL1310110003#
reversible: false
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_b726e7ef_444e_437f_b341_99a6bd1bff5f
is encoded by: hsa:5238
initial concentration: NaN
is: SBO:0000252
is: B4DX94
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
name: PGM3

http://identifiers.org/biomodels.db/MODEL1310110003#_7ad388c1_4b15_4683_bdb3_fc61358a3a53
constant: false
has only substance units: false
name: _AI653169_1_c
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:AI653169
is: SBO:0000252

metaR OAGD3tg
type: Reaction
reversible: true
reactant: MODEL1310110003#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110003#
product: MODEL1310110003#
name: oagd3 hs intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is described by: ECO:0000000

metaR CORE2GTg
reversible: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
reactant: MODEL1310110003#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.102
modifier: MODEL1310110003#
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_8fac9205_7ecb_44e1_b8f5_196b2f722b91
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:LOC728997
name: _LOC728997_1_c
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_b66d513e_6237_4ae9_98f4_bc7d6b287f1b
initial amount: NaN
is encoded by: hsa:55276
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: Q96G03
boundary condition: true
name: PGM2
constant: false

metaM q10h2 c
initial amount: NaN
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
constant: false
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB13111
is: http://identifiers.org/pubchem.compound/6504740
name: Ubiquinol-10

metaR KSII CORE2t
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
name: keratan sulfate II (core2) transport, golgi to extracellular
is: SBO:0000185
type: Reaction

metaR BILDGLCURtr
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
name: glucuronidated compound transport
type: Reaction
reactant: MODEL1310110003#
is: SBO:0000185
product: MODEL1310110003#

metaR O2Stm
reactant: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
reversible: true
product: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
name: superoxide anion transport via diffusion (mitochondria)
is: SBO:0000185
is described by: ECO:0000000

metaM maltpt e
has only substance units: false
boundary condition: false
name: maltopentaose
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
is: HMDB01296
type: Species
is: http://identifiers.org/pubchem.compound/5141
constant: false
is: SBO:0000247
is: C02052

http://identifiers.org/biomodels.db/MODEL1310110003#_033df98c_ee0a_4982_912f_1c3dac165684
type: Species
name: NIT2
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: Q9NQR4
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:56954

http://identifiers.org/biomodels.db/MODEL1310110003#_5b59adf6_3e53_4e57_8c41_1b690f9f7cfa
type: Species
name: FLAD1
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:80308
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_6632cfde_4c34_4e82_ba10_19a3a78d4def
type: Species
name: _NOS2A_1_c
is: SBO:0000252
has only substance units: false
is encoded by: hsa:NOS2A
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR S6T15g
reversible: false
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.21
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.8.2.17
fast: false

metaM m1mpdol U c
boundary condition: false
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
initial amount: NaN
has only substance units: false
is: CHEBI:28067
initial concentration: 1.0
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
is: SBO:0000247
type: Species

metaM abt e
has only substance units: false
is: CHEBI:18403
type: Species
constant: false
is: HMDB01851
is: SBO:0000247
name: L-arabinitol
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial concentration: 1.0

metaR r0181
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reactant: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
product: MODEL1310110003#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR B MANNASEly
fast: false
is described by: ECO:0000000
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: false
name: beta-mannosidase, lysosomal
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.25

metaM HC00591 m
initial concentration: 1.0
name: 2-oxoglutaramate
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
type: Species
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
is: CHEBI:16769

metaR PHCDm
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.12
modifier: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000304
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
fast: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: false
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_b96c0e36_d799_4c89_9ab9_b2661150835b
has only substance units: false
constant: false
name: PPT2
is: Q9UMR5
is encoded by: hsa:9374
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_349d8b8f_90da_4c81_9467_7a6a22166928
is: Q9Y259
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:1120
type: Species
has only substance units: false
initial concentration: NaN
name: CHKB

metaR RE1807M
reactant: MODEL1310110003#
reversible: true
type: Reaction
name: RE1807
is version of: http://identifiers.org/ec-code/1.14.13.15
product: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

metaM phe L c
is: HMDB00159
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17295
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
has only substance units: false
name: L-phenylalanine

metaR ACCOAC
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_12d6b2e1_0576_4a07_a9dd_27b76c7f13f5
name: UCP1
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P25874
is encoded by: hsa:7350
has only substance units: false

metaR r0801
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
fast: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110003#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
kinetic law: MODEL1310110003#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110003#
product: MODEL1310110003#

metaM malthx e
constant: false
initial concentration: 1.0
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
boundary condition: false
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
type: Species
is: C01936
is: SBO:0000247
name: Maltohexaose

metaR OROTGLUt
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
is: SBO:0000185
name: OROTGLUt
reversible: true
kinetic law: MODEL1310110003#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_4c6db359_fbcb_4e9d_a0cf_f781fa0ae567
constant: false
boundary condition: true
name: ALPPL2
is encoded by: hsa:251
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P10696

metaM HC02207 c
initial concentration: 1.0
is: CHEBI:27555
boundary condition: false
has only substance units: false
name: prostaglandin-c2
constant: false
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial amount: NaN
is: SBO:0000247

metaR r1434
is: SBO:0000185
name: Transport reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_51ea9e33_0239_4e1e_b7d6_4632e3b5cd39
is: P21439
initial amount: NaN
type: Species
is encoded by: hsa:5244
name: ABCB4
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN

metaM dadp c
is: HMDB01508
constant: false
is: CHEBI:57667
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: dADP
is: C00206
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206

metaM xylu L c
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00751
is: SBO:0000247
name: L-xylulose
initial amount: NaN
is: CHEBI:17399
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
has only substance units: false

metaM fol e
initial amount: NaN
constant: false
is: HMDB00121
notes: FORMULA: C19H18N7O6 CHARGE: -1
name: Folate
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species

metaR r0841
name: Free diffusion
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
reversible: true
reactant: MODEL1310110003#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.271
fast: false
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
modifier: MODEL1310110003#
type: Reaction

metaR RE3556C
is: SBO:0000176
product: MODEL1310110003#
is described by: ECO:0000000
name: RE3556
fast: false
type: Reaction
kinetic law: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
reactant: MODEL1310110003#

metaR PROSTGF2t
fast: false
name: prostaglandin uniport
reactant: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
product: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269

metaR RE3003M
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
reactant: MODEL1310110003#
reversible: true
name: RE3003
type: Reaction
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/5.3.3.8
kinetic law: MODEL1310110003#
is described by: ECO:0000000

metaR TAGt
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
name: triacylglycerol transport
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_5509a463_6ad9_4c8c_8885_75c6dce72866
boundary condition: true
is: Q6UWQ5
is: SBO:0000252
is encoded by: hsa:84569
name: LYZL1
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
type: Species

metaM ocdcea e
has only substance units: false
boundary condition: false
is: CHEBI:0
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H33O2 CHARGE: -1
is: SBO:0000247
type: Species
is: C00712
is: HMDB00207
name: octadecenoate (n-C18:1)
constant: false

metaM tmndnccoa c
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
name: timnodonyl coenzyme A
is: HMDB06514

metaR EX succ LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Succinate exchange
type: Reaction

metaR r0579
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
reversible: true
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.13.11.19
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000

metaR r0426
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
is: SBO:0000176
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
modifier: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.5.1.34
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_4f909745_8a04_4db9_afda_16b1c7484ab8
is: Q9NQ66
initial concentration: NaN
has only substance units: false
name: PLCB1
initial amount: NaN
is encoded by: hsa:23236
constant: false
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_62a88974_0c2a_49d0_82f7_a9877442c6cf
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:R14373
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: _R14373_1_x

metaM ethamp c
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
boundary condition: false
type: Species
is: HMDB00224
is: SBO:0000247
is: CHEBI:58190
initial concentration: 1.0
has only substance units: false
constant: false
name: ethamp[c]
initial amount: NaN

metaM cmpacna c
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
boundary condition: false
is: HMDB01176
type: Species
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
initial concentration: 1.0

metaR r2120
is described by: ECO:0000000
modifier: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
product: MODEL1310110003#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_f5a535e7_e5a1_48a2_9985_be65368a42dd
initial amount: NaN
is encoded by: hsa:5162
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: P11177
name: PDHB
boundary condition: true
constant: false

metaR r1433
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
reactant: MODEL1310110003#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
is: SBO:0000176
product: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
is described by: ECO:0000000

metaM udpacgal c
name: UDP-N-acetyl-D-galactosamine(2-)
is: SBO:0000247
is: HMDB00304
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: CHEBI:57847
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial concentration: 1.0

metaR FALDH
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
modifier: MODEL1310110003#
type: Reaction
reversible: true
fast: false
name: formaldehyde dehydrogenase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_19fd2d18_7d76_4c28_9d7b_af1e0a6755a0
name: CA7
initial concentration: NaN
is: Q86YU0
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:766
initial amount: NaN
type: Species
is: SBO:0000252

metaM ribflv c
type: Species
has only substance units: false
is: HMDB00244
is: CHEBI:3554
constant: false
is: C00255
name: Riboflavin
notes: FORMULA: C17H20N4O6 CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR r0202
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
is: SBO:0000176
fast: false
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
reversible: true
reactant: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
kinetic law: MODEL1310110003#

metaM utp c
type: Species
boundary condition: false
constant: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: CHEBI:46398
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: UTP
is: HMDB00285
is: C00075

metaR PHYCBOXL
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.1.1.28
is: SBO:0000176
reactant: MODEL1310110003#
modifier: MODEL1310110003#
name: L-Phenylalanine carboxy-lyase
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
product: MODEL1310110003#
fast: false
is described by: ECO:0000212

metaR r0578
type: Reaction
product: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
modifier: MODEL1310110003#
fast: false
reversible: true
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
kinetic law: MODEL1310110003#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.2.27

metaM ocdcea c
is: C00712
has only substance units: false
is: HMDB00207
name: octadecenoate (n-C18:1)
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:0
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C18H33O2 CHARGE: -1

metaR r0425
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
name: EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.17.1.4
is: SBO:0000176
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110003#

metaR r2344
type: Reaction
name: Organic anion transporter 5 Utilized transport
reactant: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110003#
fast: false
reversible: true
is described by: ECO:0000000

metaR r1088
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
name: Active transport
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_32cf4801_3ebe_40d3_ab6e_5d2f047e10a3
boundary condition: true
has only substance units: false
is: P37059
type: Species
initial concentration: NaN
is encoded by: hsa:3294
is: SBO:0000252
name: HSD17B2
constant: false
initial amount: NaN

metaM nadp r
is: HMDB00217
is: C00006
is: SBO:0000247
is: CHEBI:58349
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate
boundary condition: false

metaR r0842
name: Postulated transport reaction
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.3.1.72
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
product: MODEL1310110003#
is described by: ECO:0000000
modifier: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#
fast: false
type: Reaction
reversible: true

metaR RE2660C
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
fast: false
name: RE2660
reversible: true
is: SBO:0000176

metaR r2121
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#

metaM xan c
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00292
initial concentration: 1.0
is: C00385
constant: false
name: Xanthine
type: Species
is: CHEBI:17712
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
boundary condition: false

metaR r2511
kinetic law: MODEL1310110003#
fast: false
is: SBO:0000185
reactant: MODEL1310110003#
is described by: ECO:0000000
name: Utilized transport
reversible: true
product: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_db51021c_eee2_474a_928b_b0cce8c8a2a2
initial concentration: NaN
has only substance units: false
is: Q16795
is encoded by: hsa:4704
initial amount: NaN
name: NDUFA9
type: Species
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_c7235de7_5ffc_404c_ba07_2a35a7fa0a73
constant: false
is: A0PJJ9
initial concentration: NaN
is encoded by: hsa:2686
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
name: GGT7
type: Species

metaM succ x
name: Succinate
type: Species
constant: false
is: C00042
initial amount: NaN
is: CHEBI:30031
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00254
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_c4df592d_9ab9_4d65_b55d_f5e333765e53
has only substance units: false
name: PTS
is: SBO:0000252
constant: false
is encoded by: hsa:5805
type: Species
is: Q03393
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaR FMNAT
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
reversible: false
product: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
is: SBO:0000176
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.7.2
kinetic law: MODEL1310110003#
name: FMN adenylyltransferase

http://identifiers.org/biomodels.db/MODEL1310110003#_78b8112b_8c23_4738_9382_93f9d6f20f3a
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
name: SLC6A2
is encoded by: hsa:6530
is: Q96KH8
constant: false
initial amount: NaN
is: SBO:0000252

metaM HC02207 e
boundary condition: false
type: Species
is: CHEBI:27555
name: prostaglandin-c2
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-14,17-18,21H,2-3,5-6,8-11,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C05955
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_7a769782_87d9_4203_aa7a_a59c496f6ef4
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is: P78381
initial amount: NaN
name: SLC35A2
is encoded by: hsa:7355
has only substance units: false
is: SBO:0000252

metaR CLFORtex
name: chloride transport via formate countertransport
type: Reaction
modifier: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
fast: false
reversible: false
kinetic law: MODEL1310110003#
is described by: ECO:0000304
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB

metaR r2347
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110003#
fast: false
reversible: true
reactant: MODEL1310110003#
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
product: MODEL1310110003#
is: SBO:0000185

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR COAtg
name: CoA transport in Golgi via diffusion
type: Reaction
reactant: MODEL1310110003#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
kinetic law: MODEL1310110003#
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_2b4756ec_e3d5_4fd9_be2c_f2353c56abda
is: SBO:0000252
is: Q9Y6K8
initial concentration: NaN
is encoded by: hsa:26289
constant: false
name: AK5
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_4d833f7e_f998_4b2d_aa06_2fb00b2ed82f
initial concentration: NaN
name: PLCB4
is: SBO:0000252
is: E2QRH8
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:5332
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_04fece99_f2b4_4acd_b3cc_7a9f3f813043
has only substance units: false
constant: false
name: DUOX1
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:53905
is: Q9NRD9

metaM nadph m
is: C00005
is: CHEBI:57783
type: Species
constant: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
boundary condition: false
has only substance units: false
is: HMDB00221
initial concentration: 1.0

metaR PI345P5P
fast: false
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.36
modifier: MODEL1310110003#
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_64e910b1_0502_46f6_96a0_cac91089e401
type: Species
name: SGPP1
constant: false
boundary condition: true
is: Q9BX95
is encoded by: hsa:81537
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaM tag hs e
initial amount: NaN
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
name: triglyceride
type: Species
is: CHEBI:17855
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false

metaM tag hs c
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2 CHARGE: 0
type: Species
is: SBO:0000247
name: triglyceride
is: CHEBI:17855
has only substance units: false

metaR SERGLYexR
is: SBO:0000185
fast: false
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
name: L-Serine/Glycine reversible exchange
modifier: MODEL1310110003#
type: Reaction
reversible: true
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_8e517f65_28bb_4974_816a_b53a42c6538c
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
boundary condition: true
is encoded by: hsa:79053
initial amount: NaN
name: ALG8

metaM glc D g
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:4167
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false
type: Species
is: HMDB00122

metaM acgam1p c
is: SBO:0000247
constant: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256
type: Species
initial amount: NaN
is: CHEBI:7125
is: HMDB01367
name: N-Acetyl-D-glucosamine 1-phosphate
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR r1435
reactant: MODEL1310110003#
is: SBO:0000185
name: Transport reaction
type: Reaction
reversible: false
is described by: ECO:0000000
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
kinetic law: MODEL1310110003#

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaM utp e
constant: false
boundary condition: false
name: UTP(4-)
initial amount: NaN
is: SBO:0000247
is: CHEBI:46398
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial concentration: 1.0
has only substance units: false
is: HMDB00285
type: Species

metaR TRDR
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
product: MODEL1310110003#
type: Reaction
is described by: ECO:0000269
name: thioredoxin reductase (NADPH)
reactant: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.9
is: SBO:0000176
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: false

metaM ribflv e
has only substance units: false
is: HMDB00244
constant: false
is: CHEBI:3554
is: C00255
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: Riboflavin
type: Species
notes: FORMULA: C17H20N4O6 CHARGE: 0

metaM cholp c
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
name: choline phosphate(1-)
is: CHEBI:295975
has only substance units: false
constant: false
type: Species
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588

metaR r2346
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110003#
name: Organic anion transporter 5 Utilized transport
type: Reaction
product: MODEL1310110003#
fast: false

metaM ksii core2 pre4 g
initial amount: NaN
is: HMDB00175
is: C00130
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 4
has only substance units: false
is: CHEBI:58053
constant: false
type: Species
notes: FORMULA: C53H86N4O38X CHARGE: -1
is: SBO:0000247
boundary condition: false

metaM acgam c
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:17411
has only substance units: false
is: SBO:0000247
name: N-acetyl-D-glucosamine
is: HMDB00215
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
boundary condition: false
constant: false

metaR r2514
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
kinetic law: MODEL1310110003#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_ac81d943_3ec4_4ebd_b610_25aec6e136f3
has only substance units: false
initial concentration: NaN
name: ST3GAL3
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6487
initial amount: NaN
type: Species
constant: false

metaR LACZe
modifier: MODEL1310110003#
product: MODEL1310110003#
fast: false
type: Reaction
name: b-galactosidase, extracellular
reversible: false
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.108
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (3938.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:5774109 NOTES:Some enzymes in this group hydrolyse a-L-arabinosides; some animal enzymes also hydrolyse b-D-fucosides and b-D-glucosides; cf. EC 3.2.1.108 lactase

metaM eicostetcoa c
constant: false
has only substance units: false
type: Species
boundary condition: false
is: C16164
is: SBO:0000247
name: eicosatetranoyl coenzyme A
initial amount: NaN
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,28-30,34-36,40,51-52H,4,7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-/t30-,34-,35-,36?,40-/m1/s1
initial concentration: 1.0

metaR r1661
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110003#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110003#

metaR r2409
fast: false
reversible: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110003#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110003#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

http://identifiers.org/biomodels.db/MODEL1310110003#_32d249aa_c995_4095_af2a_b4a68e8984e5
type: Species
initial amount: NaN
is encoded by: hsa:56606
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
name: SLC2A9
initial concentration: NaN

metaR r0575
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.48
kinetic law: MODEL1310110003#
type: Reaction
fast: false
modifier: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
product: MODEL1310110003#
is: SBO:0000176
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
is described by: ECO:0000000

metaM phaccoa c
is: HMDB06503
name: phenylacetyl-CoA(4-)
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57390
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_e0595596_7e3a_481a_bf9f_89a341ead5da
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
name: SLC4A3
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:6508

http://identifiers.org/biomodels.db/MODEL1310110003#_aff66e2b_6a54_4ed4_bafa_db96b72118f9
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:9963
has only substance units: false
initial concentration: NaN
name: SLC23A1

metaM HC00342 m
type: Species
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
name: cis-aconitate(3-)
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:16383
is: SBO:0000247

metaM cmpacna g
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: HMDB01176
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_9e2a3711_cfbc_4a87_9f51_9133f5a9229e
initial concentration: NaN
is: P07741
boundary condition: true
type: Species
is encoded by: hsa:353
name: APRT
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM udpacgal g
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
is: CHEBI:57847
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: HMDB00304
has only substance units: false
name: UDP-N-acetyl-D-galactosamine(2-)
boundary condition: false
initial concentration: 1.0

metaM pyr m
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
constant: false
name: pyruvate
is: HMDB00243
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C00022
is: CHEBI:15361
type: Species
is: http://identifiers.org/pubchem.compound/3324
initial concentration: 1.0

metaR COAtm
is: SBO:0000185
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
reactant: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
reversible: true
name: CoA transporter
modifier: MODEL1310110003#
is described by: ECO:0000269
type: Reaction
product: MODEL1310110003#

metaR M7MASNBterg
fast: false
reversible: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
name: m7masnB transport from endoplasmic reticulum to Golgi apparatus

metaR GALt1r
kinetic law: MODEL1310110003#
fast: false
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
name: galactose transport (uniport)
type: Reaction
reactant: MODEL1310110003#
modifier: MODEL1310110003#

metaR r0615
is described by: ECO:0000000
product: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.168
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is: SBO:0000176
reactant: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:

metaR r2124
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110003#

metaR ADCim
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110003#
product: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
name: Acetoacetate decarboxylation (irreversible), mitochondrial
is: SBO:0000176

metaM i c
constant: false
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: CHEBI:16382
initial concentration: 1.0
initial amount: NaN
is: HMDB12238
name: iodide

metaM 20ahchsterol m
is: HMDB06283
has only substance units: false
is: SBO:0000247
is: CHEBI:1296
initial amount: NaN
boundary condition: false
constant: false
name: 20-hydroxycholesterol
initial concentration: 1.0
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500

metaR HIStiDF
reversible: false
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110003#
product: MODEL1310110003#
name: L-histidine transport via diffusion (extracellular to cytosol)
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_af18ef6e_b4c7_47f9_8829_4df5c9041381
boundary condition: true
name: INPPL1
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is: O15357
constant: false
is encoded by: hsa:3636

metaR r1662
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
fast: false

metaM CE2839 e
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5041
name: maltodecaose
has only substance units: false
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
type: Species
is: C01936

metaM orot e
has only substance units: false
name: orotate
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00226
is: CHEBI:30839
is: SBO:0000247
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
type: Species
initial concentration: 1.0

metaR S6T3g
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110003#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.17
is version of: http://identifiers.org/ec-code/2.8.2.21

http://identifiers.org/biomodels.db/MODEL1310110003#_fa140c4e_def4_4f74_ada7_a80656b83cbd
boundary condition: true
name: COX7A2L
is: Q6FGA0
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9167
has only substance units: false
constant: false
initial concentration: NaN

metaR SPODMx
is: SBO:0000176
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
reversible: false
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.15.1.1
name: superoxide dismutase, peroxisome
modifier: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_72046ac5_4141_4b39_b1bd_7bc99ef10424
is encoded by: hsa:6487
has only substance units: false
type: Species
name: ST3GAL3
is: Q5T4Y1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaR LSTO2r
name: Lathosterol oxidase
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
product: MODEL1310110003#
reversible: false
is version of: http://identifiers.org/ec-code/1.14.21.6
reactant: MODEL1310110003#

metaM 5mthf e
notes: FORMULA: C20H24N7O6 CHARGE: -1
constant: false
is: CHEBI:3729
name: 5-Methyltetrahydrofolate
type: Species
is: HMDB01396
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00440
is: SBO:0000247

metaR HISTAtu
type: Reaction
name: Histamine uniport
modifier: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000269
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110003#
reversible: true
product: MODEL1310110003#

metaM ksii core2 pre6 g
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
name: keratan sulfate II biosynthesis, precursor 6
notes: FORMULA: C61H98N5O46SX CHARGE: -2
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:28067

metaM hs deg21 l
boundary condition: false
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
initial concentration: 1.0
is: CHEBI:16126
has only substance units: false
notes: FORMULA: C37H55NO38S2 CHARGE: -4
constant: false
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_47de8ffd_4eb6_4b7c_976a_71f4de4f0fbc
initial amount: NaN
name: _AI971036_1_c
has only substance units: false
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:AI971036
initial concentration: NaN

metaR COAtn
reversible: true
name: coenzyme A transport, nuclear
product: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110003#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_2d26ab8a_2571_4ec7_a50c_374cfe7d4f52
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:BE966236
type: Species
constant: false
name: _BE966236_1_m
initial amount: NaN
has only substance units: false

metaR r2125
is described by: ECO:0000000
kinetic law: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
modifier: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
product: MODEL1310110003#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaM arachdcrn x
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01064
name: C20:4 carnitine
has only substance units: false
is: http://identifiers.org/pubchem.compound/5462164
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_e120d8d8_1d63_495a_9601_9e3a49362990
is encoded by: hsa:1891
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: ECH1
initial concentration: NaN
constant: false
is: Q13011

metaR r0616
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110003#
fast: false
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reactant: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110003#

metaM strdnccoa m
is: C16163
is: SBO:0000247
type: Species
is: HMDB06519
constant: false
initial concentration: 1.0
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
has only substance units: false
name: stearidonyl coenzyme A
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205473

metaR PPAt
kinetic law: MODEL1310110003#
reversible: false
is described by: ECO:0000000
name: Propionate transport, diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
reactant: MODEL1310110003#
is: SBO:0000185
product: MODEL1310110003#
type: Reaction
fast: false

metaM fol c
has only substance units: false
constant: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
is: SBO:0000247
is: HMDB00121
initial amount: NaN
initial concentration: 1.0
name: Folate
type: Species
boundary condition: false

metaR S6T14g
type: Reaction
modifier: MODEL1310110003#
fast: false
product: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110003#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110003#_83d98534_b456_4a6b_90e2_c08e88fcd6c7
initial amount: NaN
initial concentration: NaN
is: P19961
has only substance units: false
constant: false
is encoded by: hsa:280
boundary condition: true
is: SBO:0000252
name: AMY2B
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_e9a94f73_d581_42fd_a9fc_1f9a7b5a2d41
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is: P28330
is encoded by: hsa:33
boundary condition: true
initial amount: NaN
has only substance units: false
name: ACADL

http://identifiers.org/biomodels.db/MODEL1310110003#_e285801b_377e_4094_8a4d_bc433c8ea1a2
is: Q99714
is encoded by: hsa:3028
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: HSD17B10

metaR G14T2g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
reactant: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110003#

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaR TYRTA
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
type: Reaction
product: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
name: tyrosine transaminase
fast: false
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110003#
is described by: ECO:0000269

metaR r2122
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110003#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110003#
type: Reaction
fast: false
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_ddbe2b7c_6494_4e08_ba77_7322f8b56ad4
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI222095
has only substance units: false
name: _AI222095_1_e
type: Species
initial concentration: NaN

metaM HC02023 r
boundary condition: false
is: SBO:0000247
has only substance units: false
name: Cholesterol-ester-ol
is: CHEBI:46898
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0

metaR r0617
is: SBO:0000176
fast: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
product: MODEL1310110003#
reversible: true
type: Reaction
kinetic law: MODEL1310110003#
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is described by: ECO:0000000

metaM 3mop m
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 3-methyl-2-oxopentanoate
is: CHEBI:28654
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
is: HMDB00491

metaM nadp m
is: C00006
is: CHEBI:58349
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00217
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
constant: false
boundary condition: false
has only substance units: false
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0

metaM HC01231 c
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
name: N-[(R)-pantothenoyl]-L-cysteinate
is: SBO:0000247
is: CHEBI:58480
constant: false
initial amount: NaN

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaM dd2coa m
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:57330
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
name: trans-dodec-2-enoyl-CoA(4-)
is: SBO:0000247
is: HMDB03712

http://identifiers.org/biomodels.db/MODEL1310110003#_7062d76c_eca2_4ae9_86e4_b682472cae05
boundary condition: true
constant: false
is encoded by: hsa:2879
type: Species
is: SBO:0000252
is: P36969
initial amount: NaN
name: GPX4
initial concentration: NaN
has only substance units: false

metaR r1660
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
type: Reaction
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_a25e86c7_0af6_40f8_919a_31c4e56f9b25
name: ACAT2
boundary condition: true
is encoded by: hsa:39
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is: Q9BWD1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_cc0d5ae8_89b9_421e_96b1_6afcbfd903af
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:9154
has only substance units: false
is: Q96PL7
name: SLC28A1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_e0920b5c_065b_454b_b85a_eca53528b266
is encoded by: hsa:T83654
name: _T83654_1_m
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false

metaR r2517
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110003#
fast: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1

metaM cholp g
is: CHEBI:295975
constant: false
boundary condition: false
name: choline phosphate(1-)
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
is: C00588
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM xoltetrol c
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:17278
constant: false
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
is: HMDB01231
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_c6456f06_8e6e_4a58_936b_00f33b65dba3
has part: O15270
has only substance units: false
is: SBO:0000297
is encoded by: hsa:9517
constant: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
name: SPTLC1:SPTLC2
is encoded by: hsa:10558
has part: O15269

metaR NDP7er
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110003#
reversible: false
is: SBO:0000176

metaR ACCOAgt
reversible: true
is: SBO:0000185
product: MODEL1310110003#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
fast: false
modifier: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
name: acetyl-coa transport
kinetic law: MODEL1310110003#

metaM lys L x
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:32551
has only substance units: false
initial amount: NaN
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
boundary condition: false
name: L-lysinium(1+)

metaR LEUKTRA4t
product: MODEL1310110003#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
name: leukotriene A4 transport
reactant: MODEL1310110003#
is described by: ECO:0000269
kinetic law: MODEL1310110003#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_5996286d_c814_4442_baaa_f3be90cefd8e
constant: false
name: B3GNT3
is: Q9Y2A9
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10331
has only substance units: false

metaM 5mthf c
name: 5-Methyltetrahydrofolate
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:3729
type: Species
boundary condition: false
is: HMDB01396
initial amount: NaN
notes: FORMULA: C20H24N7O6 CHARGE: -1
is: C00440

metaR NRPPHRtu
modifier: MODEL1310110003#
is described by: ECO:0000269
name: Norepinephrine uniport
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_0a56bbe5_3fdb_4f88_a419_623ab755fd80
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:9016
name: SLC25A14
initial concentration: NaN
constant: false

metaR r0618
kinetic law: MODEL1310110003#
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
product: MODEL1310110003#
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
is described by: ECO:0000000
is: SBO:0000176

metaR r2123
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110003#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
modifier: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_4fd32210_e1f2_409f_8fa3_998a6e07969f
initial concentration: NaN
constant: false
type: Species
is: Q9NY65
is encoded by: hsa:1962
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: EHHADH

metaM anth c
has only substance units: false
initial concentration: 1.0
is: HMDB01123
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: SBO:0000247
name: anthranilate
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:16567
type: Species

metaM 6a2ohxnt x
name: 6-amino-2-oxohexanoic acid
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:17534
is: HMDB12151
constant: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
is: SBO:0000247

metaM ksi pre24 g
constant: false
is: C00130
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 24
is: HMDB00175
initial concentration: 1.0
is: CHEBI:58053
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
has only substance units: false

metaR r2128
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaR r0724
fast: false
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.1.33
type: Reaction
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#
kinetic law: MODEL1310110003#

metaR r0149
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.14.13.39
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
reversible: true
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
type: Reaction
is described by: ECO:0000000
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_7af8d156_39e8_49f6_9df4_fe0580c45964
has only substance units: false
is encoded by: hsa:4952
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: OCRL
is: Q01968
constant: false
initial amount: NaN

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR LTA4H
reactant: MODEL1310110003#
name: Leukotriene A-4 hydrolase
modifier: MODEL1310110003#
is: SBO:0000176
type: Reaction
fast: false
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.3.2.6
reversible: false
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
product: MODEL1310110003#
is described by: ECO:0000134

metaR DCK1n
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction
modifier: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000269
reactant: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000176
name: Deoxycytidine kinase, nuclear (ATP)
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_dc1fc5ff_ce59_4f68_9ffa_25db9d607b82
name: _BE042354_1_m
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:BE042354
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_224ddad0_7fe3_48bb_af52_e85e24cf42a7
is encoded by: hsa:2589
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
name: GALNT1
is: Q10472
initial concentration: NaN

metaR DOLASNT Uer
is version of: http://identifiers.org/ec-code/2.4.1.119
is described by: ECO:0000000
fast: false
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
is: SBO:0000176
modifier: MODEL1310110003#
reversible: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD
product: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR FAS140COA
modifier: MODEL1310110003#
reversible: false
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110003#
name: fatty-acyl-CoA synthase (n-C14:0CoA)
is: SBO:0000176

metaM L dpchrm c
constant: false
boundary condition: false
has only substance units: false
name: L-dopachromate
initial amount: NaN
is: HMDB01430
is: CHEBI:57509
is: SBO:0000247
notes: FORMULA: C9H6NO4 CHARGE: -1 INCHI: InChI=1S/C9H7NO4/c11-7-2-4-1-6(9(13)14)10-5(4)3-8(7)12/h2-3,6,10H,1H2,(H,13,14)/p-1/t6-/m0/s1 EHMN_ABBREVIATION: C01693
type: Species
initial concentration: 1.0

metaR r2518
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.1
reversible: true
product: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17173541 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_252fc2e9_c110_4136_a682_34c10dc4c446
name: _U37519_1_c
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:U37519

metaR RE0935E
is version of: http://identifiers.org/ec-code/3.2.1.1
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reversible: true
modifier: MODEL1310110003#
name: RE0935
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
type: Reaction

metaM anth e
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
constant: false
type: Species
initial amount: NaN
is: HMDB01123
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16567
name: anthranilate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_2c2a1f4b_384d_41c1_89b2_93b27d0cf798
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
name: _NOS2A_1_e
is encoded by: hsa:NOS2A
type: Species
initial amount: NaN

metaR EX idp LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: IDP exchange
type: Reaction

metaM HC01712 m
notes: FORMULA: C13H22NO4S2 CHARGE: -1 INCHI: InChI=1S/C13H23NO4S2/c14-11(15)5-2-1-4-10(19)8-9-20-13(18)7-3-6-12(16)17/h10,19H,1-9H2,(H2,14,15)(H,16,17) EHMN_ABBREVIATION: C06157
initial concentration: 1.0
is: SBO:0000247
type: Species
name: S-Glutaryldihydrolipoamide
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:28391

metaR GGH 7THFe
is: SBO:0000176
kinetic law: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110003#
fast: false
name: Gamma-glutamyl hydrolase (7THF), extracellular
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.4.19.9
modifier: MODEL1310110003#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_89018c90_3195_41a2_8307_ccbc75599720
type: Species
is: SBO:0000252
is encoded by: hsa:51181
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: DCXR
is: Q7Z4W1
constant: false
boundary condition: true

metaR AG13T1g
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110003#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
modifier: MODEL1310110003#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_877d156f_47a7_42a3_a57c_d09099fae665
initial amount: NaN
is encoded by: hsa:55967
constant: false
boundary condition: true
name: NDUFA12
is: F8VQS7
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species

metaM 4mop e
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:17865
initial concentration: 1.0
constant: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
boundary condition: false
name: 4-methyl-2-oxopentanoate
is: SBO:0000247
is: HMDB00695

metaR r2519
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
reactant: MODEL1310110003#
reversible: true
name: Utilized transport
is: SBO:0000185

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

metaR r2129
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
is: SBO:0000185
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
fast: false
is described by: ECO:0000000

metaM thr L c
is: HMDB00167
name: L-threonine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16857
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_6483f810_6237_4fbb_86fb_c131b05ee82a
initial amount: NaN
is: Q9BZX2
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:7371
initial concentration: NaN
boundary condition: true
name: UCK2

http://identifiers.org/biomodels.db/MODEL1310110003#_2ecb2ecd_c5cf_47b7_a91d_0f2e5ede4989
name: GMDS
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2762
has only substance units: false
is: O60547
type: Species

metaR r0726
type: Reaction
kinetic law: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000176
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.1.33

http://identifiers.org/biomodels.db/MODEL1310110003#_ead2e2a2_6b6d_4829_b04c_e5de73af3ee6
is: Q9NQR4
constant: false
is: SBO:0000252
is encoded by: hsa:56954
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
name: NIT2
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_b6093b97_dd15_4dde_bdb3_013aa57ee0e8
is: SBO:0000252
name: AKR1D1
is encoded by: hsa:6718
is: P51857
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_ea801e0e_cab8_410a_b5cd_b18da19fb64f
constant: false
is: SBO:0000252
has only substance units: false
name: ALDH2
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:217
boundary condition: true
is: P05091

http://identifiers.org/biomodels.db/MODEL1310110003#_d388da32_ae22_45f1_b085_16432e83e48c
constant: false
is: SBO:0000252
has only substance units: false
name: CA13
is encoded by: hsa:377677
initial concentration: NaN
initial amount: NaN
type: Species
is: Q8N1Q1
boundary condition: true

metaR NADH2 u10m
product: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
name: NADH dehydrogenase, mitochondrial
reactant: MODEL1310110003#
reversible: false
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.6.5.3
is: SBO:0000185
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
is version of: http://identifiers.org/ec-code/1.6.99.3

metaR r2126
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110003#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_ce05d923_3742_4b0b_94f8_dfb5a6201ff3
name: SLC7A2
is: P52569
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:6542
initial concentration: NaN
has only substance units: false

metaR SPODMn
fast: false
name: superoxide dismutase, nuclear
product: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/1.15.1.1
is: SBO:0000176
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_2472acde_c8c7_44ec_b85a_f1c873e85fa1
has only substance units: false
name: SLC38A4
type: Species
is: SBO:0000252
is encoded by: hsa:55089
is: Q969I6
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR UMPKn
name: UMP kinase, nuclear
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
reactant: MODEL1310110003#
is: SBO:0000176
fast: false
product: MODEL1310110003#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR BTNt2
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
reversible: true
fast: false
is described by: ECO:0000269
reactant: MODEL1310110003#
name: Biotin reversible transport via proton symport
type: Reaction
product: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#

metaR GK1
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.8
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110003#
name: guanylate kinase (GMP:ATP)
modifier: MODEL1310110003#

metaR RE1709N
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.96
is: SBO:0000176
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false
name: RE1709
reversible: true
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_72d05f4c_e617_4a66_bc1e_abf3b630b4d9
constant: false
type: Species
name: ALAS1
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: Q5JAM2
is: SBO:0000252
is encoded by: hsa:211
has only substance units: false

metaM acgam l
constant: false
is: HMDB00215
boundary condition: false
name: N-acetyl-D-glucosamine
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:17411
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140

metaR HMGCOASi
reactant: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (3157.1) or (3157.2) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:1358203 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission Made irreversible to match KEGG data for S. aureus
name: Hydroxymethylglutaryl CoA synthase (ir)
is described by: ECO:0000269
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.3.10
reversible: false
type: Reaction
kinetic law: MODEL1310110003#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_1013a13e_f562_4d9a_baf7_d161afdff9d7
is encoded by: hsa:200010
is: E9PAK4
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
name: SLC5A9
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_3d01e0f4_2a25_4476_9496_87f50c703fbe
is encoded by: hsa:51557
name: LGSN
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is: Q5TDP6

http://identifiers.org/biomodels.db/MODEL1310110003#_8e8d5d2e_2aeb_47ee_a4d6_3e0cc3057429
boundary condition: true
is encoded by: hsa:6241
initial concentration: NaN
constant: false
has only substance units: false
name: RRM1:RRM2
is encoded by: hsa:6240
initial amount: NaN
has part: P23921
is: SBO:0000297
has part: P31350
type: Species

metaR r2127
product: MODEL1310110003#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110003#
type: Reaction
fast: false
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110003#

metaM mmcoa R m
boundary condition: false
name: (R)-methylmalonyl-CoA(5-)
is: SBO:0000247
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
is: HMDB01269
is: CHEBI:57326
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaR r0208
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13
fast: false
is: SBO:0000176
reactant: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.4.1.1
reversible: true
kinetic law: MODEL1310110003#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_7eb961d9_acdb_4780_b102_94dd8d1e0c94
is: SBO:0000252
constant: false
name: CBS
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:875
is: Q9NTF0
initial amount: NaN

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaM glyc R m
is: HMDB00139
initial concentration: 1.0
is: CHEBI:16659
name: D-glycerate
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
has only substance units: false
boundary condition: false
type: Species

metaR SPODMm
reversible: false
is described by: ECO:0000304
type: Reaction
is version of: http://identifiers.org/ec-code/1.15.1.1
is: SBO:0000176
reactant: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
kinetic law: MODEL1310110003#
fast: false
product: MODEL1310110003#
name: superoxide dismutase

metaR PEPCK
notes: GENE_ASSOCIATION: (5105.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:17211624,PMID:17888579,PMID:17888580,PMID:8325643 NOTES:17888579 - kinetic characterization of human cytosolic form; 8325643 - homology to rat; 17211624 - immunohistochemistry for expression
is described by: ECO:0000134
fast: false
reactant: MODEL1310110003#
reversible: false
type: Reaction
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.1.1.32
product: MODEL1310110003#
is: SBO:0000176
name: Phosphoenolpyruvate carboxykinase (GTP)
kinetic law: MODEL1310110003#

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

metaR RE3520E
type: Reaction
is version of: http://identifiers.org/ec-code/1.11.1.9
kinetic law: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2880.1) or (257202.1) or (2882.1) or (2878.1) SUBSYSTEM: Arachidonic acid metabolism EC Number: 1.11.1.9 Confidence Level: 0 AUTHORS: PMID:10224163,PMID:2377602,PMID:3942774,PMID:9837935 NOTES:
name: RE3520
reversible: true
reactant: MODEL1310110003#
fast: false
modifier: MODEL1310110003#

metaM ala B m
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
constant: false
initial concentration: 1.0
is: HMDB00056
is: SBO:0000247
boundary condition: false
is: CHEBI:16958
has only substance units: false
type: Species
name: beta-alanine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_2c1d1bba_7d2d_482f_952d_da6390b6395c
initial amount: NaN
name: GMPR
constant: false
is: P36959
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2766
boundary condition: true

metaM 4mop c
is: HMDB00695
type: Species
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
initial concentration: 1.0
initial amount: NaN
name: 4-methyl-2-oxopentanoate
is: CHEBI:17865
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

metaM i e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: CHEBI:16382
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: HMDB12238
name: iodide
boundary condition: false
is: SBO:0000247

metaM thr L e
type: Species
constant: false
name: L-threonine
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: CHEBI:16857
is: HMDB00167
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_1b94858b_8cf7_4504_afd7_892ea6e6e0c1
is: P32019
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:3633
name: INPP5B
boundary condition: true

metaR FOLR2
fast: false
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.5.1.3
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
modifier: MODEL1310110003#
is: SBO:0000176
name: folate reductase
is described by: ECO:0000254
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_bba000c3_39e1_4ede_9292_dbf797311e4e
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
name: _AA278423_1_m
initial concentration: NaN
is encoded by: hsa:AA278423
has only substance units: false

metaM pyr e
is: HMDB00243
type: Species
boundary condition: false
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
initial concentration: 1.0
constant: false
is: CHEBI:15361
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: pyruvate

metaM ksi pre1 g
name: keratan sulfate I biosynthesis, precursor 1
is: CHEBI:58053
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C79H129N5O57X CHARGE: -1
is: C00130
is: HMDB00175
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_e03510e8_849d_4e7e_9d0d_c45a04f47389
is: SBO:0000252
name: _AI697028_1_e
boundary condition: true
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI697028

metaR r2341
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
type: Reaction
kinetic law: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110003#
is: SBO:0000185
reversible: true

metaM 3mox4hpac m
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB05175
is: SBO:0000247
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
initial amount: NaN
is: CHEBI:28111
type: Species
has only substance units: false

metaM nadph c
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
is: HMDB00221
is: CHEBI:57783
is: C00005
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_d7fc9cee_3a81_474e_83d6_f7e7e8d27543
is: Q9H903
name: MTHFD2L
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:441024

http://identifiers.org/biomodels.db/MODEL1310110003#_804f44cf_ab63_44b7_bac4_74fe24a55ba3
is encoded by: hsa:23563
has only substance units: false
type: Species
initial amount: NaN
is: Q9GZS9
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: CHST5

metaR r0728
kinetic law: MODEL1310110003#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
is described by: ECO:0000000
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#

metaR r0145
reactant: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
product: MODEL1310110003#
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.8.3.1
is: SBO:0000176
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39

metaM pheacgln e
constant: false
initial concentration: 1.0
is: HMDB06344
has only substance units: false
is: SBO:0000247
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial amount: NaN
boundary condition: false
is: CHEBI:58310
type: Species

metaR r0093
fast: false
reversible: false
type: Reaction
name: UDPglucose pyrophosphohydrolase Pyrimidine metabolism / Starch and sucrose metabolism EC:3.6.1.45
product: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.5.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.6.1.45 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484,PMID:12429023,PMID:12846830,PMID:1315502,PMID:2822037,PMID:2848456,PMID:3001038,PMID:4403504,PMID:7532398,PMID:7860751,PMID:8001561 NOTES:
is: SBO:0000176
modifier: MODEL1310110003#

metaR r0422
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110003#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110003#
product: MODEL1310110003#

metaM HC01231 m
is: SBO:0000247
boundary condition: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
initial concentration: 1.0
is: CHEBI:58480
type: Species
constant: false
initial amount: NaN
name: N-[(R)-pantothenoyl]-L-cysteinate
has only substance units: false

metaM m4mpdol U r
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
is: CHEBI:37633
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110003#_dac862d0_7d89_458b_9db8_a731e840c496
boundary condition: true
is encoded by: hsa:53905
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: DUOX1

metaR r1177
reactant: MODEL1310110003#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.1.1.13 Confidence Level: 0 AUTHORS: PMID:11230747,PMID:8112342 NOTES:
type: Reaction
product: MODEL1310110003#
is described by: ECO:0000000
name: EC:3.1.1.13
is: SBO:0000176
kinetic law: MODEL1310110003#
fast: false

metaM dtdp c
boundary condition: false
is: HMDB01274
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369
has only substance units: false
name: dTDP
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C00363
constant: false

metaM 3ohdcoa m
type: Species
is: HMDB06402
initial concentration: 1.0
has only substance units: false
is: CHEBI:57349
is: SBO:0000247
constant: false
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial amount: NaN
boundary condition: false
name: 3-oxopalmitoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110003#_2ef92f32_abd9_4b05_8177_4af30c8058c3
is: SBO:0000252
name: _2544_1_c
constant: false
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:2544
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_82a9f4a5_2975_47f7_920d_10b20e06b2b0
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:728637
constant: false
type: Species
initial concentration: NaN
name: _728637_1_c

http://identifiers.org/biomodels.db/MODEL1310110003#_9eb664c0_1a36_4f0f_8f81_b3ff47ee2b7c
type: Species
is: P32320
constant: false
is encoded by: hsa:978
has only substance units: false
initial amount: NaN
name: CDA
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_4352d2b7_59e3_4445_a5fe_ac1bc4fa80fa
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: P05091
has only substance units: false
name: ALDH2
constant: false
is: SBO:0000252
is encoded by: hsa:217

http://identifiers.org/biomodels.db/MODEL1310110003#_08f1feaa_36f5_462e_acaf_d3cab17b6d82
is: Q8TDY1
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8706
name: B3GALNT1
is: SBO:0000252
constant: false

metaM CE2418 m
is: HMDB11123
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
initial amount: NaN
is: CHEBI:28387
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_6da2ec9f_2895_42d1_9419_7722da246dd2
has only substance units: false
initial amount: NaN
is encoded by: hsa:7167
boundary condition: true
is: SBO:0000252
is: Q53HE2
initial concentration: NaN
constant: false
type: Species
name: TPI1

metaR PROSTGE1t
is described by: ECO:0000269
reversible: true
fast: false
kinetic law: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110003#
name: prostaglandin transport via bicarbonate countertransport
type: Reaction
reactant: MODEL1310110003#
product: MODEL1310110003#

metaR 5ADTSTSTERONEtr
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
reactant: MODEL1310110003#
name: 5 alpha dihydrotesterone intracellular transport
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_21e89cf3_b331_4aff_b1a8_6083fa069068
is: Q9NRX3
type: Species
constant: false
boundary condition: true
name: NDUFA4L2
initial concentration: NaN
is encoded by: hsa:56901
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaR G14T11g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
reactant: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.38

http://identifiers.org/biomodels.db/MODEL1310110003#_a596e8d7_73d2_4b35_82b9_478eaf0455b8
type: Species
initial amount: NaN
is: B7Z7I0
name: TKTL1
constant: false
has only substance units: false
is encoded by: hsa:8277
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR EX asn L LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-asparagine
type: Reaction

metaM glc D e
is: HMDB00122
initial amount: NaN
boundary condition: false
is: CHEBI:4167
has only substance units: false
constant: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: SBO:0000247
name: D-glucose
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_aed0c5ad_abc3_4718_8abc_90b3c8fe8ac1
is: O75610
boundary condition: true
name: LEFTY1
type: Species
initial concentration: NaN
is encoded by: hsa:10637
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_b8d01716_0a9c_453d_beb0_b5bce6bb4d2f
is encoded by: hsa:4830
name: NME1:NME2
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000297
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_259c23a1_99b6_4599_bb6b_eaf77949d21c
is: P28329
initial amount: NaN
has only substance units: false
name: CHAT
constant: false
type: Species
is encoded by: hsa:1103
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaM pyr c
boundary condition: false
is: HMDB00243
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1
is: http://identifiers.org/pubchem.compound/3324
initial concentration: 1.0
is: C00022
constant: false
has only substance units: false
is: CHEBI:15361
initial amount: NaN
is: SBO:0000247
name: pyruvate

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_718320b9_35ae_4975_b7e1_ed2f6a4de862
has only substance units: false
is: P30825
name: SLC7A1
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6541
type: Species
boundary condition: true

metaM dctp c
has only substance units: false
initial amount: NaN
is: HMDB00998
is: SBO:0000247
type: Species
is: CHEBI:16311
initial concentration: 1.0
is: C00458
constant: false
boundary condition: false
name: dCTP
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458

metaR IDOAASE2ly
type: Reaction
reversible: false
fast: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.2.1.76
name: alpha-L-iduronidase, lysosomal
product: MODEL1310110003#
kinetic law: MODEL1310110003#

metaR GluForTx
product: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
is version of: http://identifiers.org/ec-code/2.1.2.5
kinetic law: MODEL1310110003#
name: Glutamate formimidoyltransferase
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reversible: false
fast: false
reactant: MODEL1310110003#

metaR TDCHOLAte
type: Reaction
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110003#
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaR r2343
type: Reaction
reactant: MODEL1310110003#
fast: false
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR CYTK4n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
reversible: true
product: MODEL1310110003#
name: cytidylate kinase (dCMP,GTP),nuclear
fast: false
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM 56dthm c
constant: false
initial amount: NaN
is: CHEBI:27468
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906
name: 5,6-dihydrothymine
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00079

http://identifiers.org/biomodels.db/MODEL1310110003#_81d52b48_605f_4b8e_99c9_69fa65829b08
is: P33897
initial concentration: NaN
type: Species
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:215
name: ABCD1

metaR r1880
modifier: MODEL1310110003#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110003#
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110003#
is described by: ECO:0000000

metaM pheacgln c
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: HMDB06344
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: CHEBI:58310

http://identifiers.org/biomodels.db/MODEL1310110003#_3db709a8_c179_4467_9077_85d5b1318613
name: AOC2
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species
is encoded by: hsa:314
initial concentration: NaN
has only substance units: false

metaM dolglcp U r
constant: false
is: SBO:0000247
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:15812
initial amount: NaN

metaM dtdp e
is: HMDB01274
has only substance units: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial concentration: 1.0
boundary condition: false
is: CHEBI:58369
is: SBO:0000247
type: Species
constant: false
initial amount: NaN

metaR RE1525M
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.107
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
name: RE1525
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110003#
reactant: MODEL1310110003#

metaM zym int2 r
initial amount: NaN
boundary condition: false
name: zymosterol intermediate 2
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:52386
constant: false
is: SBO:0000247
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110003#_136cd77a_b633_43aa_9672_617f2bd3cb7b
constant: false
is: P27338
initial concentration: NaN
name: MAOB
boundary condition: true
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:4129

metaM ksi pre8 g
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 8
constant: false
type: Species
is: CHEBI:28067
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
initial amount: NaN

metaM HC00822 l
initial concentration: 1.0
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
is: CHEBI:28681
constant: false
name: Chitobiose
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN

metaM dhea r
boundary condition: false
is: HMDB00077
initial amount: NaN
type: Species
initial concentration: 1.0
has only substance units: false
name: 3beta-hydroxyandrost-5-en-17-one
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
is: SBO:0000247
constant: false
is: CHEBI:28689

metaM 3dsphgn c
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
is: HMDB01480
has only substance units: false
boundary condition: false
is: CHEBI:58299

metaR r0295
kinetic law: MODEL1310110003#
fast: false
is: SBO:0000176
reactant: MODEL1310110003#
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:

metaM ha pre1 e
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
has only substance units: false
boundary condition: false
is: CHEBI:16126
constant: false
initial amount: NaN
type: Species
name: hyaluronan biosynthesis, precursor 1

metaR r0423
type: Reaction
fast: false
product: MODEL1310110003#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
modifier: MODEL1310110003#
reactant: MODEL1310110003#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR r0142
is described by: ECO:0000000
fast: false
type: Reaction
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
product: MODEL1310110003#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110003#_c5d20364_49f6_44cf_a390_9aea5d6f5c69
initial concentration: NaN
constant: false
is encoded by: hsa:54407
boundary condition: true
is: Q96QD8
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: SLC38A2

http://identifiers.org/biomodels.db/MODEL1310110003#_95b81f89_3cf0_429d_9cd6_5fcb98de6aee
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
name: _AV727634_1_c
initial amount: NaN
is encoded by: hsa:AV727634
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_cfb27c08_3cef_4908_b7d6_7683febe69b8
has only substance units: false
name: _AA278423_1_c
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:AA278423
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM glc D c
constant: false
type: Species
initial amount: NaN
is: CHEBI:4167
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
boundary condition: false
name: D-glucose
is: HMDB00122
initial concentration: 1.0

metaR ACETONEt2m
is: SBO:0000185
reactant: MODEL1310110003#
name: acetone mitochondrial transport via proton symport
fast: false
kinetic law: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
type: Reaction
product: MODEL1310110003#

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

metaR ASCBt
kinetic law: MODEL1310110003#
reversible: true
product: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
type: Reaction
is: SBO:0000185
fast: false
name: L-ascorbate transport via facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD

metaR r0086
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
fast: false
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.1.3
reactant: MODEL1310110003#

metaM bilirub e
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00054
name: bilirubin(2-)
is: CHEBI:57977
constant: false
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_37ca34dd_ec45_495e_8891_22ff4dcae878
is encoded by: hsa:7296
name: TXNRD1
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false

metaR r1586
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_708b605e_9818_4bb6_a48c_48bc3b85e0d7
is: P15291
initial amount: NaN
constant: false
boundary condition: true
name: B4GALT1
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2683
type: Species

metaR r0355
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110003#
reversible: false
product: MODEL1310110003#
is: SBO:0000176
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.3

metaM pep c
name: Phosphoenolpyruvate
constant: false
is: SBO:0000247
is: C00074
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
initial concentration: 1.0
type: Species
is: HMDB00263
boundary condition: false
is: CHEBI:18021

http://identifiers.org/biomodels.db/MODEL1310110003#_eae24815_b9fe_4332_a56a_7922a0e3d256
initial amount: NaN
constant: false
is: E7EUT4
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2597
boundary condition: true
has only substance units: false
name: GAPDH
type: Species

metaM gln L c
type: Species
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: L-glutamine
is: HMDB00641
is: CHEBI:18050
constant: false
initial amount: NaN

metaR R group phosphotase 1
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000000
name: R group phosphotase 1
type: Reaction
reversible: false
fast: false
is: SBO:0000176

metaR HAS2
kinetic law: MODEL1310110003#
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110003#
is: SBO:0000185
reversible: false
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.212
name: hyaluronan synthase

metaR EX dheas LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dehydroepiandrosterone sulfate exchange
type: Reaction

metaM guln c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
name: L-gulonate
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
has only substance units: false
constant: false
is: HMDB03290
boundary condition: false
is: CHEBI:13115

metaM ump c
is: HMDB00288
is: C00105
name: UMP
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaM HC02214 e
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:28852
name: prostaglandin-f1alpha
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_ce41b379_0289_485e_8820_52ec30b1ae09
is: Q9P0J0
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: NDUFA13
is encoded by: hsa:51079

metaM m2mpdol U c
constant: false
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:28049
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
is: SBO:0000247
initial amount: NaN
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0

metaM nadp c
is: SBO:0000247
is: C00006
initial amount: NaN
type: Species
constant: false
boundary condition: false
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false
is: HMDB00217
initial concentration: 1.0
is: CHEBI:58349
name: Nicotinamide adenine dinucleotide phosphate

http://identifiers.org/biomodels.db/MODEL1310110003#_b664cc44_d49c_4b28_b370_46a35f21e330
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2686
name: GGT7
initial amount: NaN
constant: false
has only substance units: false
is: A0PJJ9
type: Species
boundary condition: true

metaM dtdp n
initial amount: NaN
is: HMDB01274
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:58369
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
type: Species
constant: false
boundary condition: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate

metaR r1587
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
reversible: true
kinetic law: MODEL1310110003#
is: SBO:0000185
fast: false

metaM mi14p c
is: HMDB00968
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
is: CHEBI:58282
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_787072db_c844_46f4_acaf_f6a1f023d880
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2348
type: Species
initial concentration: NaN
constant: false
name: FOLR1
has only substance units: false
boundary condition: true

metaR CREATt4 2 r
product: MODEL1310110003#
name: Creatine transport (sodium symport) (2:1)
fast: false
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction
reactant: MODEL1310110003#
is described by: ECO:0000269
kinetic law: MODEL1310110003#
reversible: true
is: SBO:0000185
modifier: MODEL1310110003#

metaR PIPLC
is described by: ECO:0000000
type: Reaction
fast: false
name: phosphatidylinositol phospholipase C
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
modifier: MODEL1310110003#
reversible: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_5da08e09_f41e_4d49_b1db_f9f69a96d0ad
initial concentration: NaN
name: A4GALT
has only substance units: false
constant: false
is: Q9NPC4
is: SBO:0000252
is encoded by: hsa:53947
type: Species
initial amount: NaN
boundary condition: true

metaR r0354
reversible: false
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110003#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is: SBO:0000176
reactant: MODEL1310110003#

metaR r0085
product: MODEL1310110003#
reversible: false
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3

metaR r0942
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
is: SBO:0000185

metaM lys L c
initial concentration: 1.0
is: HMDB00182
boundary condition: false
name: L-lysinium(1+)
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
has only substance units: false
initial amount: NaN
is: CHEBI:32551
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_8212da9a_c693_4e16_82dc_a51772915268
initial amount: NaN
is: P56181
has only substance units: false
is encoded by: hsa:4731
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
boundary condition: true
name: NDUFV3

http://identifiers.org/biomodels.db/MODEL1310110003#_3dbd48f4_67c6_4855_99a2_813bfcf85215
type: Species
is: P61457
initial amount: NaN
is encoded by: hsa:5092
constant: false
has only substance units: false
is: SBO:0000252
name: PCBD1
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_af0250d8_5bb4_490b_92fd_6f0f254ec432
is encoded by: hsa:171425
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: Q8N0X4
has only substance units: false
type: Species
name: CLYBL
constant: false

metaM CE5161 r
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB00127
initial concentration: 1.0
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
constant: false
type: Species
is: CHEBI:15748
has only substance units: false

metaM btn e
notes: FORMULA: C10H15N2O3S CHARGE: -1
initial amount: NaN
type: Species
name: Biotin
is: C00120
initial concentration: 1.0
is: SBO:0000247
is: HMDB00030
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:3420

metaR NDPK3n
type: Reaction
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
product: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_dfddbdc3_ae73_40d4_9d59_2c183e49e3c4
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AF116616
name: _AF116616_1_m
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_f8fc7293_36a1_44bb_b10b_dc0475fb1932
is encoded by: hsa:38
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: ACAT1
is: P24752

http://identifiers.org/biomodels.db/MODEL1310110003#_b3d3f894_fcd2_4487_8fc2_b9c9132ffa1f
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: E9PCI1
has only substance units: false
is: SBO:0000252
is encoded by: hsa:53
type: Species
name: ACP2

metaM arachdcrn m
is: CHEBI:57387
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
type: Species
is: HMDB01322
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: C20:4 carnitine
is: SBO:0000247
has only substance units: false

metaR r1588
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110003#
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#

metaM bilirub c
type: Species
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:57977
is: HMDB00054
constant: false
has only substance units: false
name: bilirubin(2-)
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
initial amount: NaN

metaM ala B e
has only substance units: false
type: Species
is: CHEBI:16958
name: beta-alanine
is: HMDB00056
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
initial concentration: 1.0

metaM ump e
is: SBO:0000247
is: HMDB00288
is: CHEBI:57865
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
name: UMP(2-)

metaM lnlncacoa c
is: HMDB06290
type: Species
initial concentration: 1.0
is: CHEBI:51985
constant: false
boundary condition: false
initial amount: NaN
name: alpha-Linolenoyl-CoA
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_a58c416c_4f7e_43cc_95f8_ca19d1ef4554
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: PANK2
is: SBO:0000252
is: Q6P1K9
has only substance units: false
boundary condition: true
is encoded by: hsa:80025

http://identifiers.org/biomodels.db/MODEL1310110003#_b6f48b4e_6a70_41c5_8526_6b3807ea5b80
is encoded by: hsa:10678
boundary condition: true
type: Species
is: Q9NY97
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: B3GNT2
has only substance units: false
constant: false

metaR LEUKTRF4t
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110003#
fast: false
type: Reaction
product: MODEL1310110003#
name: leukotriene F4 transport
reversible: true
is: SBO:0000185

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR AG13T15g
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
fast: false
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#

metaM sarcs c
notes: FORMULA: C3H7NO2 CHARGE: 0
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: Sarcosine
constant: false
boundary condition: false
is: CHEBI:3513
is: HMDB00271
is: SBO:0000247
is: C00213

metaR GLYBt4 2 r
product: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000269
name: Betaine transport (sodium symport) (2:1)
notes: GENE_ASSOCIATION: (6539.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110003#

metaM forglu c
is: CHEBI:18327
has only substance units: false
initial amount: NaN
type: Species
is: C00439
is: HMDB00854
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
name: N-Formimidoyl-L-glutamate
constant: false
boundary condition: false

metaR FAOXC80
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000176
type: Reaction
fast: false
name: Beta oxidation of med/long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM CE2422 m
boundary condition: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
is: HMDB11123
initial amount: NaN
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
initial concentration: 1.0
is: CHEBI:28387
has only substance units: false
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_94d481ac_de82_4da8_80eb_bf4aaa7b0208
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:2222
constant: false
name: FDFT1
has only substance units: false
is: P37268

metaR DHCHOLESTANATEtm
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction

metaM nac c
name: Nicotinate
is: HMDB01488
is: CHEBI:0
constant: false
notes: FORMULA: C6H4NO2 CHARGE: -1
initial amount: NaN
is: C00253
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_0c74c737_7bef_4f71_8561_d8e917bfb4ee
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: MVD
type: Species
is encoded by: hsa:4597
is: P53602
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_669ab591_3dd0_455c_8f8d_b6f9404c984d
boundary condition: true
type: Species
initial concentration: NaN
constant: false
name: MOGS
is: SBO:0000252
is encoded by: hsa:7841
is: F5H6D0
has only substance units: false
initial amount: NaN

metaM hLkynr c
boundary condition: false
constant: false
notes: FORMULA: C10H12N2O4 CHARGE: 0 INCHI: InChI=1S/C10H12N2O4/c11-6(10(15)16)4-8(14)5-2-1-3-7(13)9(5)12/h1-3,6,13H,4,11-12H2,(H,15,16)/t6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01079 EHMN_ABBREVIATION: C03227
type: Species
has only substance units: false
name: 3-hydroxy-L-kynurenine
is: HMDB11631
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17380
is: SBO:0000247

metaR GUAPRT
is version of: http://identifiers.org/ec-code/2.4.2.8
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: false
is: SBO:0000176
modifier: MODEL1310110003#
product: MODEL1310110003#
name: guanine phosphoribosyltransferase
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110003#_c89d9a87_7599_4201_b9c3_6282917088bf
constant: false
initial concentration: NaN
name: NDUFC2
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is: Q549M5
is encoded by: hsa:4718
type: Species

metaR SMPD3g
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
is: SBO:0000176
type: Reaction
is described by: ECO:0000304
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.4.12
kinetic law: MODEL1310110003#
reversible: false
reactant: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_dce9c60b_a1f5_4857_9864_493e19cb7671
is encoded by: hsa:4712
initial amount: NaN
constant: false
has part: Q5VYT2
is: SBO:0000297
is encoded by: hsa:4731
type: Species
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR r1589
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110003#
fast: false
is described by: ECO:0000000

metaM o2s x
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
constant: false
type: Species
is: CHEBI:18421
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB02168
name: superoxide
boundary condition: false
has only substance units: false

metaM ethamp r
is: CHEBI:58190
is: HMDB00224
is: SBO:0000247
has only substance units: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
initial amount: NaN
constant: false
name: O-phosphonatoethanaminium(1-)
boundary condition: false
initial concentration: 1.0
type: Species

metaM hco3 m
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
is: C00288
initial amount: NaN
is: SBO:0000247
is: CHEBI:17544
boundary condition: false
is: HMDB00595
name: Bicarbonate

metaM gar c
constant: false
is: C03838
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:58457
initial amount: NaN
type: Species
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
is: HMDB02022
name: N1-(5-Phospho-D-ribosyl)glycinamide
initial concentration: 1.0

metaM pchol hs e
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: Phosphatidylcholine
is: CHEBI:16110
boundary condition: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_e7bd074b_10af_49b6_a897_27b0c3ceeb87
is: P35557
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:2645
initial amount: NaN
has only substance units: false
name: GCK

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaM lys L e
is: SBO:0000247
name: L-lysinium(1+)
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00182
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_afa0b24c_0fe1_4608_bb4b_c8098bd87ccc
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5052
boundary condition: true
name: PRDX1

metaM hspg l
is: CHEBI:17899
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: HMDB01993
has only substance units: false
name: heparan sulfate proteoglycan
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247

metaM btn c
has only substance units: false
name: Biotin
boundary condition: false
is: HMDB00030
initial amount: NaN
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: SBO:0000247
is: CHEBI:3420
initial concentration: 1.0
constant: false
type: Species
is: C00120

metaR r0944
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
fast: false
reversible: true
reactant: MODEL1310110003#
product: MODEL1310110003#
name: Active transport
kinetic law: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_86c1676f_cc32_4f91_870d_e9a5f85c3d81
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
name: _AI972237_1_c
is encoded by: hsa:AI972237

metaR 5ADTSTSTERONEte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
fast: false
name: 5 alpha dihydrotesterone transport
product: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction

metaM glac r
constant: false
is: CHEBI:18268
initial concentration: 1.0
type: Species
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
boundary condition: false
name: D-glucurono-6,3-lactone
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB06355

metaR URIt4
name: uridine transport in via sodium symport
is described by: ECO:0000269
reversible: false
fast: false
is: SBO:0000185
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (9154.2) or (9154.1) or (64078.1) or (9153.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:SAB
product: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#

metaM arachcoa e
initial concentration: 1.0
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
is: CHEBI:15527
name: arachidyl coenzyme A
constant: false
boundary condition: false
type: Species
is: HMDB04258
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaM glu L m
is: CHEBI:29985
constant: false
name: L-glutamate(1-)
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
type: Species
has only substance units: false
is: HMDB00148

metaM CE5162 r
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: HMDB00127
is: SBO:0000247
name: trans,cis-2,9-octadecadienoyl-CoA
constant: false
initial amount: NaN
is: CHEBI:15748
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
type: Species

metaM CE5786 e
type: Species
is: HMDB02710
is: CHEBI:27485
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: kinetensin
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786

http://identifiers.org/biomodels.db/MODEL1310110003#_8f363aea_3579_42a4_ae45_f80b83a9067c
type: Species
has only substance units: false
is encoded by: hsa:3099
is: P52789
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
name: HK2
is: SBO:0000252

metaM ump g
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247
is: HMDB00288
name: UMP(2-)
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:57865
initial concentration: 1.0
boundary condition: false

metaM ala B c
boundary condition: false
is: HMDB00056
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:16958
initial concentration: 1.0
constant: false
has only substance units: false
name: beta-alanine

metaR ACGAMK
name: N-acetylglucosamine kinase
kinetic law: MODEL1310110003#
is described by: ECO:0000269
type: Reaction
fast: false
is: SBO:0000176
reversible: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.59
reactant: MODEL1310110003#
modifier: MODEL1310110003#

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaM retinal cis 13 r
is: HMDB06220
has only substance units: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:45487
name: 13-cis-retinal

metaM 2dr1p c
boundary condition: false
has only substance units: false
name: 2-Deoxy-D-ribose 1-phosphate
is: HMDB01351
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:58576
type: Species
is: C00672
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial amount: NaN

metaR GLNtm
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
is: SBO:0000185
name: L-glutamine transport via electroneutral transporter
is described by: ECO:0000000
reversible: false
type: Reaction
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_c11c23da_429e_401a_97f7_2b6e745205ca
boundary condition: true
is encoded by: hsa:64834
constant: false
is: Q9BW60
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ELOVL1

metaR UMPK7n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
name: UMP kinase (dGTP),nuclear
is described by: ECO:0000269
reversible: true
product: MODEL1310110003#
is: SBO:0000176

metaR SQLSr
is described by: ECO:0000134
name: Squalene synthase
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.5.1.21
product: MODEL1310110003#
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110003#_84d5a800_e5fb_4449_8d03_b773acf34249
is: SBO:0000252
is encoded by: hsa:53354
boundary condition: true
has only substance units: false
name: PANK1
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_f52e13e3_1171_4fb4_add0_2602e3a610e7
boundary condition: true
is: SBO:0000252
name: ALDH7A1
has only substance units: false
constant: false
type: Species
initial concentration: NaN
is: E7EPT3
initial amount: NaN
is encoded by: hsa:501

http://identifiers.org/biomodels.db/MODEL1310110003#_2bb4b299_5cf3_4418_b28e_fd4316a8b10f
name: _H53099_1_m
is encoded by: hsa:H53099
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaR GLYCTDle
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110003#
reactant: MODEL1310110003#
name: difussion of glycerol accross the brush border membrane
kinetic law: MODEL1310110003#
is described by: ECO:0000134
reversible: true
fast: false
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_c8aa8e05_daca_45d7_83fa_06d8b320a2cf
is encoded by: hsa:AI631997
name: _AI631997_1_m
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_4c2fd6e7_a22c_4555_8890_88c475e3d383
is encoded by: hsa:9651
constant: false
has only substance units: false
is: SBO:0000252
name: PLCH2
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: O75038
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_0daeff5f_915c_4244_bdb8_1e5c4451975a
name: _AI285872_1_c
boundary condition: true
is encoded by: hsa:AI285872
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN

metaR SUCD1m
is version of: http://identifiers.org/ec-code/1.3.5.1
type: Reaction
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
name: succinate dehydrogenase
is: SBO:0000176
reversible: true
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110003#_d37caa00_c435_4b53_9b1d_a569eac0737c
constant: false
is: SBO:0000252
boundary condition: true
name: PPCS
initial amount: NaN
type: Species
is: Q9HAB8
has only substance units: false
initial concentration: NaN
is encoded by: hsa:79717

metaM CE0693 m
is: CHEBI:28387
name: 3-oxolaur-6-cis-enoyl-CoA
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB11123
type: Species

metaR r1583
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
fast: false
reversible: true

metaM mev R c
name: (R)-mevalonate
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00227
initial concentration: 1.0
is: CHEBI:36464
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
constant: false

metaM mescoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:27969
initial amount: NaN
is: C06028
name: Mesaconyl-CoA
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_f82cc1ea_d096_4219_83d8_9bce9559e8e1
constant: false
type: Species
is: Q05C14
is encoded by: hsa:2352
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: FOLR3
boundary condition: true

metaR S2TASE2ly
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.6.13
is described by: ECO:0000000
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reactant: MODEL1310110003#
reversible: false
kinetic law: MODEL1310110003#
type: Reaction
name: iduronate-2-sulfatase, lysosomal
fast: false
is: SBO:0000176

metaM dgmp e
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
has only substance units: false
is: CHEBI:57673
is: HMDB01044
type: Species
name: dGMP(2-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_dbe29347_928c_461a_bd4d_c92770dc68c8
boundary condition: true
is encoded by: hsa:5337
name: PLD1
initial amount: NaN
constant: false
initial concentration: NaN
is: Q59EA4
type: Species
is: SBO:0000252
has only substance units: false

metaR r0127
reactant: MODEL1310110003#
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.5.4.16
name: L-Asparagine amidohydrolase Alanine and aspartate metabolism / Cyanoamino acid metabolism / Nitrogen metabolism EC:3.5.1.1 EC:3.5.1.38
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.38 Confidence Level: 0 AUTHORS: PMID:4311065,PMID:4894450 NOTES:
modifier: MODEL1310110003#
is described by: ECO:0000000
type: Reaction

metaR TRIODTHYt2
product: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
reversible: true
modifier: MODEL1310110003#
name: T3 transport via facilitated diffusion
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110003#_12c86bba_535e_4bc1_b3cd_05f4b92ef2b7
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:4710
is: O95168
has only substance units: false
name: NDUFB4
boundary condition: true

metaM HC02217 c
type: Species
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
boundary condition: false
name: prostaglandin-g2
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27647
has only substance units: false

metaM glysar e
has only substance units: false
is: http://identifiers.org/pubchem.compound/93131
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0
name: Glycylsarcosine
boundary condition: false
initial amount: NaN

metaR r0946
type: Reaction
product: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM ser L e
is: SBO:0000247
constant: false
is: CHEBI:17115
is: HMDB00187
name: L-serine
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false

metaM glysar c
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/93131
boundary condition: false
constant: false
notes: FORMULA: C5H10N2O3 CHARGE: 0
initial concentration: 1.0
name: Glycylsarcosine
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_dea11c7b_77d0_478a_853b_3b11f64610a8
boundary condition: true
is encoded by: hsa:2593
has only substance units: false
name: GAMT
initial concentration: NaN
type: Species
is: Q14353
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_09ec3164_b2e8_4c8b_bcba_3112e45e2eaa
is encoded by: hsa:54
type: Species
initial amount: NaN
name: ACP5
is: P13686
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_6641f8f2_d8bb_44ee_bcfc_9197964b44a0
constant: false
is: SBO:0000252
is encoded by: hsa:223
boundary condition: true
initial amount: NaN
name: ALDH9A1
has only substance units: false
is: P49189
initial concentration: NaN
type: Species

metaM f1a g
notes: FORMULA: C22H37N2O15X CHARGE: 0
is: HMDB02917
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: F1alpha
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:17151
type: Species

metaM HC02214 c
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:28852
is: SBO:0000247
initial amount: NaN
constant: false
name: prostaglandin-f1alpha
notes: FORMULA: C20H35O5 CHARGE: -1 INCHI: InChI=1S/C20H36O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-19,21-23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-,19+/m0/s1
initial concentration: 1.0

metaR r1584
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185
reactant: MODEL1310110003#

metaM dtdp m
is: HMDB01274
is: C00363
name: dTDP
initial concentration: 1.0
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:58369
initial amount: NaN

metaR BDMT U
reactant: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.142
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110003#
is described by: ECO:0000000
kinetic law: MODEL1310110003#
reversible: false
product: MODEL1310110003#

metaR R group phosphotase 3
reactant: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
reversible: false
fast: false
name: R group phosphotase 3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
product: MODEL1310110003#

metaR RE2999M
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/5.3.3.8
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
modifier: MODEL1310110003#
is: SBO:0000176
name: RE2999
kinetic law: MODEL1310110003#
is described by: ECO:0000000

metaM nh4 e
type: Species
initial concentration: 1.0
is: HMDB00051
name: ammonium
has only substance units: false
is: SBO:0000247
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
is: CHEBI:28938
constant: false
boundary condition: false

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaM 2maacoa m
initial concentration: 1.0
is: SBO:0000247
name: 2-methylacetoacetyl-CoA(4-)
is: HMDB01157
has only substance units: false
type: Species
notes: FORMULA: C26H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-13,15,18-20,24,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01101 EHMN_ABBREVIATION: C03344
initial amount: NaN
is: CHEBI:57335
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_e531f224_6998_4048_a77d_76e1a814a438
is: Q9H0P0
is: SBO:0000252
is encoded by: hsa:51251
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: NT5C3
constant: false

metaR RE1447N
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
name: RE1447
is: SBO:0000176
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:

metaM ksi pre35 g
is: CHEBI:28067
has only substance units: false
is: SBO:0000247
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
constant: false
name: keratan sulfate I biosynthesis, precursor 35

http://identifiers.org/biomodels.db/MODEL1310110003#_d50c0f8e_71a7_45db_ba39_aba031637a68
type: Species
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:400410
is: Q9HBF5
has only substance units: false
initial concentration: NaN
name: ST20
is: SBO:0000252

metaM arachcoa c
constant: false
boundary condition: false
is: HMDB04258
type: Species
is: CHEBI:15527
has only substance units: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial concentration: 1.0
is: SBO:0000247
name: arachidyl coenzyme A
initial amount: NaN

metaR r0735
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110003#
reversible: true
is: SBO:0000176
reactant: MODEL1310110003#
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38

http://identifiers.org/biomodels.db/MODEL1310110003#_da3357c1_c1b5_4471_8624_20539ce33f3c
name: NDUFB7
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4713
has only substance units: false
is: P17568
is: SBO:0000252
type: Species
constant: false
boundary condition: true

metaM gln L e
is: HMDB00641
is: SBO:0000247
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
has only substance units: false
constant: false
is: CHEBI:18050
initial amount: NaN
name: L-glutamine
boundary condition: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_0d88a706_4830_4583_96a9_6f593a878395
initial concentration: NaN
is encoded by: hsa:3295
boundary condition: true
constant: false
type: Species
name: HSD17B4
is: SBO:0000252
initial amount: NaN
is: E9PB82
has only substance units: false

metaM hs deg5 l
initial concentration: 1.0
is: HMDB00158
initial amount: NaN
is: CHEBI:17895
has only substance units: false
boundary condition: false
name: heparan sulfate, degradation product 5
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C67H97N4O86S10 CHARGE: -11

http://identifiers.org/biomodels.db/MODEL1310110003#_3ba745ee_64d2_41e6_986c_cc0effab951c
constant: false
type: Species
name: PYCRL
has only substance units: false
is: SBO:0000252
is: Q53H96
boundary condition: true
initial amount: NaN
is encoded by: hsa:65263
initial concentration: NaN

metaR FADH2ETC
is: SBO:0000176
reversible: false
product: MODEL1310110003#
name: Complex II reaction for respiratory chain
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_e153b9a4_5b96_411a_94a8_718fe27e7b85
is: O76062
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false
name: TM7SF2
is encoded by: hsa:7108
type: Species
initial concentration: NaN

metaR DNDPt8m
fast: false
is: SBO:0000185
modifier: MODEL1310110003#
name: dADP transport via dUDP antiport
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
reversible: false
kinetic law: MODEL1310110003#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaM dgmp c
name: dGMP
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:57673
type: Species
is: C00362
is: HMDB01044
initial concentration: 1.0
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362

metaR r1585
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
kinetic law: MODEL1310110003#
reversible: true

metaR R group phosphotase 2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
type: Reaction
is: SBO:0000176
name: R group phosphotase 2
product: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: false

metaM HC00822 e
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: Chitobiose
is: CHEBI:28681
is: SBO:0000247
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674
constant: false

metaR RE1447M
is: SBO:0000176
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.41
fast: false
name: RE1447
type: Reaction
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
kinetic law: MODEL1310110003#
reversible: true
product: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#

metaR r0129
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.40
product: MODEL1310110003#
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_ab959a77_fe8c_451a_b866_656f7aebcc02
constant: false
is: SBO:0000252
is: Q7Z4L0
initial concentration: NaN
is encoded by: hsa:341947
name: COX8C
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true

metaM HC02217 e
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:27647
constant: false
boundary condition: false
name: prostaglandin-g2
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956

metaM ser L c
initial amount: NaN
name: L-serine
is: CHEBI:17115
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00187
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_ce312aad_2a53_401e_9a03_18c1ac71b7e9
initial concentration: NaN
is encoded by: hsa:3032
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: HADHB
has only substance units: false
type: Species
constant: false
is: P55084

metaM thcholstoic c
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: SBO:0000247
has only substance units: false
is: HMDB03873
constant: false
initial amount: NaN
type: Species
is: CHEBI:18402
boundary condition: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722

metaM sucsal m
initial amount: NaN
is: HMDB01259
is: CHEBI:57706
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
has only substance units: false
type: Species
initial concentration: 1.0
name: Succinic semialdehyde
constant: false
is: SBO:0000247
boundary condition: false

metaM glc D r
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
is: HMDB00122
initial amount: NaN
name: D-glucose
is: CHEBI:4167
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_224d7875_0077_41a9_8e87_86848d0a749d
type: Species
has only substance units: false
name: PTGS2
boundary condition: true
is: SBO:0000252
constant: false
is: P35354
is encoded by: hsa:5743
initial concentration: NaN
initial amount: NaN

metaR r0838
is described by: ECO:0000000
reactant: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
type: Reaction
name: Free diffusion
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
fast: false
modifier: MODEL1310110003#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.4

metaM sarcs m
type: Species
notes: FORMULA: C3H7NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00197 EHMN_ABBREVIATION: C00213
is: C00213
boundary condition: false
is: HMDB00271
constant: false
name: Sarcosine
is: CHEBI:15611
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_85b7714a_7a30_4758_8f32_eecfec8e53df
name: MAOA
constant: false
is: Q53YE7
initial amount: NaN
type: Species
is encoded by: hsa:4128
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR COAtr
product: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
name: COA transporter, endoplasmic reticulum
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true
fast: false

metaM hs deg16 l
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
name: heparan sulfate, degradation product 16
initial amount: NaN
notes: FORMULA: C49H72N2O54S4 CHARGE: -6
is: SBO:0000247
is: CHEBI:21338
is: HMDB02704

metaM nh4 c
is: SBO:0000247
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: C01342
is: CHEBI:28938
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00051
name: Ammonium
initial concentration: 1.0
type: Species

metaM hdd2coa m
type: Species
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB03945
initial concentration: 1.0
has only substance units: false
name: trans-Hexadec-2-enoyl-CoA
initial amount: NaN
is: CHEBI:61526
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: C05272

metaR CYSSNAT5tc
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_7a226b2e_a239_4176_9f03_ee2bc17626c9
boundary condition: true
is: SBO:0000252
name: PYCRL
is: Q53H96
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:65263
has only substance units: false
constant: false
type: Species

metaR CERT1gt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
reactant: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000304
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
is: SBO:0000185
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
name: ceramide transport protein

http://identifiers.org/biomodels.db/MODEL1310110003#_86e7273c_7755_427c_bda4_c7aac464d754
is encoded by: hsa:11182
boundary condition: true
has only substance units: false
name: SLC2A6
is: SBO:0000252
is: Q9UGQ3
initial concentration: NaN
type: Species
constant: false
initial amount: NaN

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_ca2e1fe9_9001_4bfd_8342_ce6cc52cb554
initial amount: NaN
boundary condition: true
is: O95992
initial concentration: NaN
name: CH25H
has only substance units: false
is encoded by: hsa:9023
constant: false
type: Species
is: SBO:0000252

metaR r1666
is described by: ECO:0000000
modifier: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: true
name: Y+LAT2 Utilized transport

metaR r0570
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
product: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.3.3.2
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176
modifier: MODEL1310110003#

metaR HSAT1ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is described by: ECO:0000000
name: heparan-glucosaminide N-acetyltransferase, lysosomal
reversible: false
fast: false
reactant: MODEL1310110003#
type: Reaction
is: SBO:0000185
product: MODEL1310110003#
kinetic law: MODEL1310110003#

metaM atp e
is: HMDB00538
name: ATP(4-)
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:57299
is: SBO:0000247
type: Species
initial concentration: 1.0
is: C00002
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_3bd15ace_d74e_4ef7_9506_9b1776b1f0e1
initial amount: NaN
is encoded by: hsa:4714
is: O95169
name: NDUFB8
constant: false
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_43e1f755_d9d9_4787_af59_d244cde56ab6
is encoded by: hsa:1215
is: SBO:0000252
boundary condition: true
type: Species
is: Q4FEB3
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: CMA1

metaR KCC2t
is: SBO:0000185
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
reactant: MODEL1310110003#
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
name: K+-Cl- cotransporter (NH4+)
product: MODEL1310110003#
is described by: ECO:0000269
fast: false
type: Reaction
reversible: true

metaM inost c
is: SBO:0000247
is: HMDB00211
initial amount: NaN
is: CHEBI:17268
constant: false
type: Species
has only substance units: false
name: myo-inositol
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
boundary condition: false

metaR A4GALTg
is: SBO:0000176
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
is version of: http://identifiers.org/ec-code/2.4.1.228
reactant: MODEL1310110003#
name: Lactosylceramide 4-alpha-galactosyltransferase
modifier: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000269
kinetic law: MODEL1310110003#
fast: false
type: Reaction
reversible: false

metaR RE3421R
type: Reaction
name: RE3421
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
product: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110003#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_617bebe7_393b_4ac9_9ec7_c24dffb91c6f
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10327
name: AKR1A1

http://identifiers.org/biomodels.db/MODEL1310110003#_d268b3e3_f26a_41ad_8374_0a3adf8bc415
boundary condition: true
name: _H17063_1_m
initial amount: NaN
is encoded by: hsa:H17063
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
constant: false

metaR NAHCO3 HCLt
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
is: SBO:0000185
type: Reaction
reactant: MODEL1310110003#
name: bicarbonate transport (HCl/NaHCO3 exchange)
is described by: ECO:0000269
modifier: MODEL1310110003#

metaR r1500
is: SBO:0000185
type: Reaction
reactant: MODEL1310110003#
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
fast: false
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#

metaR TDCHOLAtx
name: bile acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110003#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_012ae75b_d395_424a_aa64_c912d43daa19
name: SCD5
constant: false
type: Species
is encoded by: hsa:79966
is: Q86SK9
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR ILEtec
product: MODEL1310110003#
is: SBO:0000185
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
is described by: ECO:0000269
type: Reaction
name: L-isoleucine transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110003#
reversible: true
fast: false
reactant: MODEL1310110003#

metaR SARDHm
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176
fast: false
product: MODEL1310110003#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.99.1
is described by: ECO:0000269
name: Sarcosine dehydrogenase (m)
type: Reaction
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable

http://identifiers.org/biomodels.db/MODEL1310110003#_dc900fc4_b223_4bdc_a740_ec0fb387d61d
initial concentration: NaN
name: ADSL
type: Species
is: P30566
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:158
initial amount: NaN
is: SBO:0000252

metaR r1665
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_6c509aae_9459_4194_a20d_ee19481565ba
initial concentration: NaN
type: Species
name: TXNRD1
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:7296

metaM ksi pre31 g
constant: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 31
is: CHEBI:58053
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C227H363N16O189S9X CHARGE: -10
is: C00130
type: Species
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_14bf1849_887f_4530_b3b9_c91e67daf1ce
has only substance units: false
boundary condition: true
constant: false
is: B7Z6M3
type: Species
initial concentration: NaN
name: DGKZ
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8525

http://identifiers.org/biomodels.db/MODEL1310110003#_5145f390_fb68_461a_857e_dcf53fd901b1
has only substance units: false
initial concentration: NaN
boundary condition: true
name: SLC24A3
is: Q9HC58
constant: false
initial amount: NaN
is encoded by: hsa:57419
is: SBO:0000252
type: Species

metaM 6thf e
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/169691
is: SBO:0000247
constant: false
boundary condition: false
name: hexaglutamyl folate (THF)
initial concentration: 1.0
type: Species
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1

metaM chtn e
type: Species
is: CHEBI:17029
initial amount: NaN
notes: FORMULA: C24H41N3O16 CHARGE: 0 INCHI: InChI=1S/C24H41N3O16/c1-7(31)25-13-18(36)20(11(5-29)39-22(13)38)42-24-15(27-9(3)33)19(37)21(12(6-30)41-24)43-23-14(26-8(2)32)17(35)16(34)10(4-28)40-23/h10-24,28-30,34-38H,4-6H2,1-3H3,(H,25,31)(H,26,32)(H,27,33)/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02118
has only substance units: false
is: SBO:0000247
boundary condition: false
name: chitin
is: HMDB03362
constant: false
initial concentration: 1.0

metaM xoltriol c
is: HMDB01457
boundary condition: false
has only substance units: false
is: CHEBI:16496
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454

metaR GGH 5DHFe
type: Reaction
kinetic law: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.4.19.9
name: Gamma-glutamyl hydrolase (5DHF), extracellular
is: SBO:0000176
fast: false
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reversible: false

metaR COAtp
name: coenzyme A transport, peroxisomal
is described by: ECO:0000000
kinetic law: MODEL1310110003#
is: SBO:0000185
reversible: true
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110003#
fast: false

metaR NADtx
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000134
name: transport of NAD into peroxisome
product: MODEL1310110003#
type: Reaction

metaR GBA
notes: GENE_ASSOCIATION: (2629.2) or (2629.3) or (2629.4) or (2629.5) or (2629.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 0 AUTHORS: PMID:15982918 NOTES:NJ
type: Reaction
reactant: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000176
name: Glucosylceramidase
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.2.1.45
product: MODEL1310110003#
fast: false
reversible: false
modifier: MODEL1310110003#

metaR r1664
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110003#
is: SBO:0000185
product: MODEL1310110003#
reversible: true
type: Reaction
reactant: MODEL1310110003#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_47b3a136_b7b2_46b3_bf3f_4c2586f49ec7
constant: false
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false
name: CTPS2
initial amount: NaN
initial concentration: NaN
is: Q9NRF8
is encoded by: hsa:56474

metaR r1580
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110003#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_18bf3cf3_9e02_479f_b3b1_41f7382b7c06
name: RPE
is: Q53TV9
has only substance units: false
initial amount: NaN
is encoded by: hsa:6120
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species

metaM dhap x
is: http://identifiers.org/pubchem.compound/3411
type: Species
is: SBO:0000247
constant: false
is: HMDB01473
is: C00111
initial concentration: 1.0
has only substance units: false
name: Dihydroxyacetone phosphate
boundary condition: false
initial amount: NaN
is: CHEBI:57642

metaR FAOXC226205m
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is: SBO:0000176
fast: false
modifier: MODEL1310110003#
name: Beta oxidation of long chain fatty acid
reversible: false

metaM atp c
boundary condition: false
initial amount: NaN
is: HMDB00538
constant: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:30616
name: ATP(4-)
is: C00002
has only substance units: false

metaR r1936
is described by: ECO:0000000
product: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: false
name: Y+LAT2 Utilized transport

metaR RE1903R
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
is: SBO:0000176
name: RE1903
product: MODEL1310110003#

metaR RE3198C
fast: false
is: SBO:0000176
reversible: true
product: MODEL1310110003#
name: RE3198
reactant: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11744399 NOTES:
kinetic law: MODEL1310110003#

metaM inost e
is: CHEBI:17268
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
has only substance units: false
boundary condition: false
constant: false
name: myo-inositol
initial concentration: 1.0
type: Species
is: HMDB00211
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_b678eac0_2a1d_468f_b1c2_f73b65242ec0
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is: P30520
initial concentration: NaN
is encoded by: hsa:159
type: Species
name: ADSS

metaR AICARte
is described by: ECO:0000134
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
reversible: true
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_bea3b4ed_7788_42ed_b7b9_bc6452f2919c
constant: false
initial amount: NaN
is: SBO:0000252
name: ACAD10
has only substance units: false
boundary condition: true
is encoded by: hsa:80724
initial concentration: NaN
is: G3XAJ0
type: Species

metaR r0839
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.70
product: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
reactant: MODEL1310110003#
is: SBO:0000185
modifier: MODEL1310110003#
reversible: true
fast: false
name: Postulated transport reaction

metaM ksi pre18 g
initial concentration: 1.0
has only substance units: false
is: CHEBI:58053
boundary condition: false
type: Species
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
initial amount: NaN
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 18
is: SBO:0000247
constant: false
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110003#_51ccf9f3_619f_4228_a837_2b11e6d0d0e7
is encoded by: hsa:374907
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: B3GNT8
initial amount: NaN
has only substance units: false

metaM fald c
is: CHEBI:16842
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: formaldehyde
is: SBO:0000247
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
type: Species
is: HMDB01426

metaR CORE6GTg
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.102
type: Reaction
fast: false
reversible: false
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110003#_4566fa6a_f965_4877_8553_813054e65363
constant: false
boundary condition: true
is encoded by: hsa:3157
is: SBO:0000252
type: Species
has only substance units: false
name: HMGCS1
initial amount: NaN
initial concentration: NaN

metaM HC00342 c
is: CHEBI:16383
constant: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
name: cis-aconitate(3-)
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR S3TASE3ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
fast: false
reversible: true
name: N-acetylglucosamine-3-sulfatase, lysosomal
kinetic law: MODEL1310110003#

metaM tmndnccoa m
has only substance units: false
constant: false
is: HMDB06514
is: SBO:0000247
name: timnodonyl coenzyme A
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
type: Species
boundary condition: false

metaR r1581
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_fe7336c5_bdd8_4dbf_ab5b_b4b0a5285c4f
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:6546
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: SLC8A1
is: F6VPY9

metaR ARGtiDF
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
name: L-arginine transport via diffusion (extracellular to cytosol)
is described by: ECO:0000269
reversible: false
type: Reaction

MODEL1310110003
reaction: metaR M4MPDOL Uter
species: metaM h2o x
species: metaM anth e
reaction: metaR THRGLYexR
reaction: metaR DNDPt33m
species: metaM pmtcrn r
reaction: metaR Asn X Ser Thrtr
reaction: metaR ASNtN1
species: metaM hs deg13 l
species: metaM dtdp c
reaction: metaR URIt4
reaction: metaR EX ala B LPAREN e RPAREN
reaction: metaR NICRNS
reaction: metaR r2371
species: metaM cmp e
species: metaM co2 e
reaction: metaR r2332
reaction: metaR r0735
reaction: metaR RE2999M
species: metaM m2mpdol U c
species: metaM icit c
species: metaM gsn c
species: metaM HC02214 c
reaction: metaR PCm
reaction: metaR r1418
reaction: metaR r1020
reaction: metaR r0841
species: metaM dtmp e
reaction: metaR RE1845X
reaction: metaR COAtp
reaction: metaR DNDPt35m
species: metaM C04849 e
species: metaM datp n
reaction: metaR RTOTAL2t
reaction: metaR r1377
species: metaM ipdp c
reaction: metaR G14T16g
reaction: metaR r2115
reaction: metaR r1400
species: metaM crn r
reaction: metaR r1051
reaction: metaR MG2er
species: metaM leu L e
species: metaM h2o c
species: metaM val L e
reaction: metaR r1565
reaction: metaR r0400
species: metaM tdcoa c
reaction: metaR r2526
reaction: metaR r0295
species: metaM HC00900 c
species: metaM glac r
reaction: metaR UMPK6n
species: metaM dgmp m
species: metaM hco3 m
reaction: metaR SPH1Pte
species: metaM malt e
species: metaM ksi pre24 g
reaction: metaR G14T10g
species: metaM dcholcoa c
reaction: metaR RE1810M
species: metaM andrstandn r
species: metaM HC02175 e
reaction: metaR r1634
reaction: metaR r0911
reaction: metaR PGS
species: metaM lnlncg r
species: metaM dutp c
reaction: metaR r1585
reaction: metaR 3MOX4HOXPGALDOX NADP
species: metaM acnam c
reaction: metaR GLYSNAT5tc
reaction: metaR r2386
species: metaM dgchol c
reaction: metaR EX ade LPAREN e RPAREN
reaction: metaR r2331
species: metaM arachcoa m
species: metaM chsterol m
reaction: metaR EX for LPAREN e RPAREN
reaction: metaR RE2660N

metaM arachdcrn c
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
is: SBO:0000247
type: Species
is: CHEBI:57387
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: HMDB01322
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_55a15b7c_ac61_4f78_88e0_100deb77b6e1
is: SBO:0000297
has part: P82251
has part: Q07837
is encoded by: hsa:11136
has only substance units: false
is encoded by: hsa:6519
name: SLC7A9:SLC3A1
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

metaM hspg e
name: heparan sulfate proteoglycan
initial concentration: 1.0
constant: false
is: HMDB00719
has only substance units: false
is: CHEBI:15699
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C79H113N5O101S12X CHARGE: -13

metaR DHEAtr
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: 2.8.2.2 Confidence Level: 1 AUTHORS: PMID:11535246,PMID:1588921 NOTES:
type: Reaction
name: Dehydroepiandrosterone transport
is described by: ECO:0000269
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_ce4afbcf_9a7f_4a4f_97fc_70e43eee6601
is: O00330
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: PDHX
type: Species
is encoded by: hsa:8050
initial concentration: NaN
constant: false

metaM g2m8mpdol U r
is: CHEBI:59093
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
constant: false
initial concentration: 1.0
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_db27e5b9_8789_4aa9_bb57_ca0e45d61d60
is: O95045
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
name: UPP2
is encoded by: hsa:151531
is: SBO:0000252
type: Species
initial amount: NaN

metaR UGALNACtg
is described by: ECO:0000269
modifier: MODEL1310110003#
reversible: true
fast: false
product: MODEL1310110003#
type: Reaction
is: SBO:0000185
name: UDP-GalNAc Golgi transport via CMP antiport
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
kinetic law: MODEL1310110003#

metaM nadph r
is: SBO:0000247
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
is: CHEBI:57783
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: HMDB00221
type: Species
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false
is: C00005

metaM m4mpdol U c
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
boundary condition: false
is: CHEBI:37633
initial amount: NaN
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: SBO:0000247
constant: false
type: Species

metaR INSt
name: Inosine transport (diffusion)
reactant: MODEL1310110003#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
kinetic law: MODEL1310110003#
fast: false
product: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_977cc981_3be4_45ad_a61d_7322c1842641
has only substance units: false
is encoded by: hsa:219
type: Species
constant: false
is: SBO:0000252
name: ALDH1B1
is: P30837
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM glyc R c
type: Species
is: HMDB00139
initial concentration: 1.0
is: CHEBI:16659
constant: false
initial amount: NaN
name: D-glycerate
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR r0834
modifier: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.4.16

metaR Asn X Ser Thrtr
fast: false
product: MODEL1310110003#
reversible: true
is: SBO:0000185
name: Asn-X-Ser/Thr transport (from ER to lysosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_a07f9e40_a626_4237_8e6f_7f8d17c76fe6
name: NDUFA4
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4697
type: Species
is: O00483
initial concentration: NaN
constant: false
boundary condition: true

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_9716cf55_80c8_4a82_b0d7_22e97ff3010c
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: SMPD3
is: Q9NY59
initial concentration: NaN
is encoded by: hsa:55512

metaM dolglcp U c
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: CHEBI:15812
has only substance units: false
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog

metaR AG13T8g
is described by: ECO:0000000
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
reversible: false

metaM hs deg18 l
is: SBO:0000247
boundary condition: false
type: Species
name: heparan sulfate, degradation product 18
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:15699
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
is: HMDB00719

http://identifiers.org/biomodels.db/MODEL1310110003#_c44bf7a5_7569_45ca_ad07_7402515fef6a
boundary condition: true
initial amount: NaN
name: SLC25A15
is: SBO:0000252
has only substance units: false
is: Q9Y619
constant: false
type: Species
is encoded by: hsa:10166
initial concentration: NaN

metaR HXPRT
fast: false
product: MODEL1310110003#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.8
reactant: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
reversible: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine (see GUAPRT) and 6-mercaptopurine can replace hypoxanthine
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_107048ca_6de2_473a_af7e_5bc9f8e0ebc5
name: SLC7A10:SLC3A2
is encoded by: hsa:56301
boundary condition: true
has part: Q9NS82
constant: false
is encoded by: hsa:6520
initial concentration: NaN
initial amount: NaN
has only substance units: false
has part: P08195
type: Species
is: SBO:0000297

metaM CE2431 m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
name: cis-deca-4-enoyl-CoA
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:57795
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR GLYAMDTRc
fast: false
product: MODEL1310110003#
is described by: ECO:0000269
is: SBO:0000176
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.4.1
modifier: MODEL1310110003#
name: glycine amidinotransferase (c)
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (2628.1) SUBSYSTEM: Urea cycle EC Number: 2.1.4.1 Confidence Level: 4 AUTHORS: PMID:8547310 NOTES:SAB c

metaM hs deg9 l
boundary condition: false
has only substance units: false
is: HMDB06355
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C61H87N3O76S8 CHARGE: -10
name: heparan sulfate, degradation product 9
is: CHEBI:18268
constant: false

metaM ser L m
is: HMDB00187
name: L-serine
is: SBO:0000247
is: CHEBI:17115
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
boundary condition: false

metaR r1669
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
kinetic law: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
type: Reaction
fast: false
is: SBO:0000185
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110003#_4f909b02_a393_49a4_adf4_0387b8357d1d
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:23057
initial amount: NaN
name: NMNAT2
boundary condition: true
constant: false

metaM HC02206 c
name: prostaglandin C1(1-)
boundary condition: false
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
constant: false
type: Species
initial amount: NaN
is: CHEBI:57399
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_af44f067_bc11_4447_93b0_1825209dbb44
constant: false
name: GART
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2618
initial concentration: NaN
initial amount: NaN
is: P22102
type: Species
boundary condition: true

metaR RE2660N
is version of: http://identifiers.org/ec-code/4.2.1.96
type: Reaction
reactant: MODEL1310110003#
reversible: true
name: RE2660
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
product: MODEL1310110003#

metaM dgmp m
name: dGMP
type: Species
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: C00362
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:57673
initial amount: NaN
is: HMDB01044
has only substance units: false
constant: false

metaR 3HKYNAKGAT
reversible: false
product: MODEL1310110003#
fast: false
type: Reaction
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
name: 3-Hydroxy-L-kynurenine:2-oxoglutarate aminotransferase
is described by: ECO:0000304
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.7
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 2 AUTHORS: PMID:13357462 NOTES:SAB
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.6.1.64

metaM f1a l
has only substance units: false
is: CHEBI:17151
boundary condition: false
is: HMDB02917
notes: FORMULA: C22H37N2O15X CHARGE: 0
constant: false
is: SBO:0000247
type: Species
name: F1alpha
initial concentration: 1.0
initial amount: NaN

metaR ASCBt4
notes: GENE_ASSOCIATION: (9962.2) or (9963.1) or (9962.1) or (9963.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10471399,PMID:10556483,PMID:10556521,PMID:10631088,PMID:15705056 NOTES:NCD
reactant: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#
name: L-ascorbate transport via proton symport
type: Reaction
reversible: true
product: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000269
fast: false

metaR GGH 6THFe
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
name: Gamma-glutamyl hydrolase (6THF), extracellular
product: MODEL1310110003#
is described by: ECO:0000000
modifier: MODEL1310110003#
fast: false
type: Reaction
reversible: false

metaR VLCSp
modifier: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: false
is: SBO:0000176
name: Very-long-chain-fatty-acid-CoA ligase
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110003#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ

metaR SERtN1
reversible: true
reactant: MODEL1310110003#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000269
name: Serine transport (Na, H coupled)
fast: false
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_fef594e3_0c4a_4c56_9e0a_4cd72f5c1176
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: SLC9A5
is encoded by: hsa:6553
is: Q9NSW9

http://identifiers.org/biomodels.db/MODEL1310110003#_4cfc5f99_b86d_4c18_87c0_acbbfb2daa9d
name: GBA
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:2629
type: Species
initial amount: NaN
has only substance units: false

metaM ksi pre22 g
has only substance units: false
is: HMDB00175
initial concentration: 1.0
initial amount: NaN
is: C00130
constant: false
name: keratan sulfate I biosynthesis, precursor 22
is: CHEBI:58053
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
type: Species
boundary condition: false
is: SBO:0000247

metaM dadp m
constant: false
name: dADP(3-)
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:57667
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
is: SBO:0000247
is: HMDB01508
initial concentration: 1.0

metaR CO2tm
name: CO2 transport (diffusion), mitochondrial
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
kinetic law: MODEL1310110003#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110003#
is: SBO:0000185

metaR P5CRm
fast: false
name: pyrroline-5-carboxylate reductase (m)
type: Reaction
reversible: false
kinetic law: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000304
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (5831.1) or (5831.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 2 AUTHORS: NOTES:
modifier: MODEL1310110003#
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.5.1.2

metaR r1668
reversible: true
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110003#
reactant: MODEL1310110003#
fast: false

metaM HC00718 c
has only substance units: false
name: N-methylethanolaminium phosphate(1-)
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
initial amount: NaN
boundary condition: false
is: CHEBI:57781
type: Species

metaM pchol hs r
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:16110
boundary condition: false
initial concentration: 1.0
type: Species
name: Phosphatidylcholine
constant: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157

metaR DAGKn hs
notes: GENE_ASSOCIATION: (8525.1) or (9162.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.7.1.107
name: Diacylglycerol phosphate kinase (homo sapiens)
reactant: MODEL1310110003#
type: Reaction
reversible: true
modifier: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#
is described by: ECO:0000269

metaR It
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000269
reactant: MODEL1310110003#
fast: false
is: SBO:0000185
type: Reaction
name: Iodide uniport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_1b50f99d_904d_4203_b933_1c45092b33c9
is: SBO:0000252
name: NDUFB9
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
is: Q9Y6M9
boundary condition: true
is encoded by: hsa:4715

metaM gln L m
is: HMDB00641
constant: false
name: L-glutamine
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: CHEBI:18050

http://identifiers.org/biomodels.db/MODEL1310110003#_a4390cb9_3db5_4c26_beed_5d2101c33c78
constant: false
name: ACOT7
boundary condition: true
type: Species
is encoded by: hsa:11332
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: O00154

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR GLYt7 211 r
product: MODEL1310110003#
name: glycine reversible transport via sodium and chloride symport (2:1:1)
is: SBO:0000185
type: Reaction
modifier: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110003#
fast: false
is described by: ECO:0000269

metaR GLCNACPT U
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
reversible: false
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.8.15
type: Reaction
reactant: MODEL1310110003#
product: MODEL1310110003#
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
kinetic law: MODEL1310110003#

metaR r1431
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1
fast: false
type: Reaction
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
reactant: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
kinetic law: MODEL1310110003#

metaM 5fthf m
initial amount: NaN
is: HMDB01562
initial concentration: 1.0
type: Species
name: 5-formyltetrahydrofolate(2-)
has only substance units: false
is: CHEBI:57457
is: SBO:0000247
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
boundary condition: false

metaR DNDPt23m
name: dTDP transport via dGTP antiport
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
reactant: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110003#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110003#_d1da4b8c_a754_4f3d_ac4d_6915b84b2b1c
boundary condition: true
name: GOT1
initial amount: NaN
is encoded by: hsa:2805
has only substance units: false
is: P17174
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN

metaM dadp n
type: Species
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O9P2/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(23-7)2-22-26(20,21)24-25(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)/p-3/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial concentration: 1.0
has only substance units: false
name: dADP(3-)
is: CHEBI:57667
is: SBO:0000247
is: HMDB01508
constant: false
initial amount: NaN
boundary condition: false

metaR r0835
is: SBO:0000185
modifier: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
type: Reaction
product: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.5.4.16
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_8c52db81_8658_4c25_975e_d458a364faf2
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2182
boundary condition: true
constant: false
is: Q5JWV8
name: ACSL4

metaM HC02206 e
type: Species
is: CHEBI:57399
name: prostaglandin C1(1-)
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686

metaR r1667
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110003#
fast: false
type: Reaction
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_75869d52_4e4f_4468_b542_b72931f7b0b4
constant: false
is: E9PCP2
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: CPT1B
initial amount: NaN
is encoded by: hsa:1375
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_ed20263f_9f01_46b4_98d4_e77b1d444f42
initial amount: NaN
initial concentration: NaN
is: Q9BZW2
constant: false
is: SBO:0000252
is encoded by: hsa:6561
type: Species
boundary condition: true
has only substance units: false
name: SLC13A1

metaR 34DHXMANDACOX
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (221.1) or (218.1) or (220.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110003#
reversible: false
modifier: MODEL1310110003#

metaR ITPtn
name: ITP nuclear transport
product: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#

metaR RTOTAL2t
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
fast: false
product: MODEL1310110003#
type: Reaction
name: RTOTAL2 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_fd42b92e_3f4e_464d_ae55_4286fba448dd
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:1503
boundary condition: true
is: P17812
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: CTPS1

http://identifiers.org/biomodels.db/MODEL1310110003#_6d79fe80_ac11_4481_b164_70e7a1d39925
constant: false
is encoded by: hsa:30833
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: Q8TCD5
name: NT5C
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_e4f7ee2a_5ba3_4df3_b400_3b9c1fc07412
constant: false
initial amount: NaN
is: Q9BZ23
is encoded by: hsa:80025
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
name: PANK2

http://identifiers.org/biomodels.db/MODEL1310110003#_8d9c0d43_982b_4459_bfb6_889b67a35401
is encoded by: hsa:276
name: AMY1A
boundary condition: true
is: Q6NSB3
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR r1008
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
fast: false
reversible: false
is: SBO:0000185
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_f78d6f83_e054_4c36_adbb_e608c8654eab
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
name: FOLR1
is: P15328
constant: false
is encoded by: hsa:2348

metaR NTD5m
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110003#
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110003#
name: 5'-nucleotidase (dTMP), mitochondrial
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.3.5
reactant: MODEL1310110003#

metaM m8mpdol U r
has only substance units: false
initial amount: NaN
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
type: Species
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
is: CHEBI:59093

http://identifiers.org/biomodels.db/MODEL1310110003#_1dc982b6_22ef_44a0_b867_65a5bcd5097e
is encoded by: hsa:8560
type: Species
name: DEGS1
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: O15121
initial concentration: NaN

metaM h m
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: proton
is: C00080
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

metaR GLNtN1
name: Glutamine transport (Na, H coupled)
product: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
reversible: true
modifier: MODEL1310110003#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827

metaM 6pgl r
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01127
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
type: Species
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
is: CHEBI:57955
initial amount: NaN
constant: false

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR LEUGLYHYc
name: hydrolysis of leucylglycine
reversible: true
fast: false
product: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.

http://identifiers.org/biomodels.db/MODEL1310110003#_09006fe1_6b79_4178_9be2_715371ab649e
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: P23786
is: SBO:0000252
constant: false
is encoded by: hsa:1376
name: CPT2

metaR r2130
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110003#
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110003#

metaR DOLP Uter
kinetic law: MODEL1310110003#
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
reversible: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
name: dolichol phosphate flippase (uterus)
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_2e1beb7e_8c12_4d64_809a_88354e15600f
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:3906
initial concentration: NaN
type: Species
is: SBO:0000297
name: B4GALT1:LALBA
has part: P00709

metaR r2359
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
reversible: true
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport

metaR MTHFD
name: methylenetetrahydrofolate dehydrogenase (NADP)
is described by: ECO:0000134
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.5.1.5
notes: GENE_ASSOCIATION: (4522.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
type: Reaction
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000176
reversible: true
fast: false
product: MODEL1310110003#

metaR GMPR
is described by: ECO:0000269
is: SBO:0000176
name: GMP reductase
reversible: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.7.1.7
modifier: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:

metaR GGH 10FTHF5GLUe
name: Gamma-glutamyl hydrolase (10FTHF5GLU), extracellular
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.4.19.9
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
fast: false
reversible: false
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#

metaM guln r
initial amount: NaN
boundary condition: false
type: Species
name: L-gulonate
is: SBO:0000247
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
has only substance units: false
is: CHEBI:13115
constant: false
is: HMDB03290
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_a8d753a6_e6ce_41d4_99a2_4c0d4a5f2e8e
initial amount: NaN
boundary condition: true
is encoded by: hsa:55293
is: Q8IX04
is: SBO:0000252
constant: false
initial concentration: NaN
name: UEVLD
has only substance units: false
type: Species

metaR r0494
kinetic law: MODEL1310110003#
is described by: ECO:0000000
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
type: Reaction
is: SBO:0000176
product: MODEL1310110003#
reactant: MODEL1310110003#

metaM glu L c
is: HMDB00148
boundary condition: false
initial concentration: 1.0
name: L-glutamate(1-)
is: CHEBI:29985
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_4490bbe5_7ad8_4af0_94a5_5c971ed87976
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
name: ATIC
constant: false
initial concentration: NaN
is encoded by: hsa:471
is: SBO:0000252
is: P31939

metaM h l
is: SBO:0000247
constant: false
is: C00080
type: Species
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: "
name: proton
boundary condition: false
is: CHEBI:24636
initial concentration: 1.0

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

metaM glac c
initial amount: NaN
name: D-glucurono-6,3-lactone
initial concentration: 1.0
boundary condition: false
is: HMDB06355
constant: false
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:18268
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1

metaR r2131
is: SBO:0000185
modifier: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_126b955a_73c9_4ead_9d7b_08e8923843b0
initial amount: NaN
has only substance units: false
is: P14324
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2224
constant: false
initial concentration: NaN
name: FDPS
type: Species

metaM dpcoa c
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
name: Dephospho-CoA
is: CHEBI:57328
is: C00882
is: HMDB01373
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882

metaR GLCNACASE3ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reversible: false
kinetic law: MODEL1310110003#
fast: false
is described by: ECO:0000000
product: MODEL1310110003#
name: alpha-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.2.1.50
type: Reaction

metaR r2358
fast: false
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is described by: ECO:0000000

metaR PROSTGI2t
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
reversible: true
reactant: MODEL1310110003#
name: Prostaglandin I2 transport
product: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#
type: Reaction

metaM retfa c
type: Species
has only substance units: false
constant: false
name: fatty acid retinol
boundary condition: false
is: CHEBI:50211
is: HMDB00305
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaR AMETr
name: S-Adenosyl-L-methionine intracellular diffusion
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
is: SBO:0000185
reversible: true

metaR RE0453C
type: Reaction
kinetic law: MODEL1310110003#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
reactant: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
name: RE0453
product: MODEL1310110003#

metaR SUCOASm
is version of: http://identifiers.org/ec-code/6.2.1.5
name: Succinate--CoA ligase (ADP-forming)
is version of: http://identifiers.org/ec-code/6.2.1.4
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
type: Reaction
reactant: MODEL1310110003#
reversible: true
fast: false
product: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110003#

metaR C226CRNt
name: C226 transport into the mitochondria
kinetic law: MODEL1310110003#
reversible: false
type: Reaction
reactant: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000000
product: MODEL1310110003#
fast: false

metaR GLCt4
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000269
name: glucose transport via sodium symport
reactant: MODEL1310110003#
reversible: true
is: SBO:0000185
modifier: MODEL1310110003#
fast: false
type: Reaction

metaR r1384
reversible: true
type: Reaction
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
fast: false
product: MODEL1310110003#
name: Guanosine aminohydrolase EC:3.5.4.15
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.15 Confidence Level: 0 AUTHORS: PMID:10348987,PMID:14725335 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_75444b5d_ebb2_4b99_964e_bfa96b1f4fee
is encoded by: hsa:114134
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SLC2A13
type: Species
initial concentration: NaN
has only substance units: false
is: Q96QE2

metaM 2mop c
initial concentration: 1.0
type: Species
name: 2-methyl-3-oxopropanoate
constant: false
is: HMDB01172
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial amount: NaN
is: CHEBI:57700
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR q10h2tc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110003#
fast: false
is described by: ECO:0000134
name: transport of ubiquinol into cytosol
is: SBO:0000185
kinetic law: MODEL1310110003#
reversible: true
type: Reaction
product: MODEL1310110003#

metaR RE1342C
reversible: true
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110003#
name: RE1342
type: Reaction
reactant: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
kinetic law: MODEL1310110003#

metaR r2132
modifier: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110003#
reversible: true
product: MODEL1310110003#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110003#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM ksi pre7 g
is: CHEBI:58053
notes: FORMULA: C115H187N8O85SX CHARGE: -2
is: HMDB00175
has only substance units: false
constant: false
is: SBO:0000247
is: C00130
boundary condition: false
type: Species
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 7
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_d79102bd_0b0e_4158_bc50_82a0e1038dee
is encoded by: hsa:51292
initial concentration: NaN
constant: false
is: Q86T14
has only substance units: false
name: GMPR2
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN

metaR r2357
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110003#
reversible: true
fast: false
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185

metaM fadh2 m
is: C01352
is: SBO:0000247
boundary condition: false
is: CHEBI:58307
name: Flavin adenine dinucleotide reduced
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01197
initial amount: NaN
type: Species

metaM HC01610 e
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:28607
has only substance units: false
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
name: CoproporphyrinogenI
initial amount: NaN
type: Species
initial concentration: 1.0

metaM sphmyln hs g
is: SBO:0000247
name: sphingomyelin betaine
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:58216
type: Species

metaM h n
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:24636
boundary condition: false
is: SBO:0000247
name: proton
initial concentration: 1.0

metaM mi145p c
has only substance units: false
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
is: SBO:0000247
is: HMDB01498
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)
is: CHEBI:203600
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_51ec7021_5a1d_49cf_9601_fdafe886832d
initial concentration: NaN
type: Species
is: Q9NR34
is encoded by: hsa:57134
boundary condition: true
initial amount: NaN
name: MAN1C1
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_be5b76ec_ea62_4c99_b164_323a0a796b79
has only substance units: false
is encoded by: hsa:1375
initial concentration: NaN
initial amount: NaN
name: CPT1B
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is: Q92523

http://identifiers.org/biomodels.db/MODEL1310110003#_32ac2e7e_a1ae_4205_aed6_b165f6c531ed
initial amount: NaN
has only substance units: false
name: GGT1
is: P19440
boundary condition: true
constant: false
is encoded by: hsa:2678
type: Species
is: SBO:0000252
initial concentration: NaN

metaM hdca l
is: CHEBI:7896
is: SBO:0000247
initial amount: NaN
name: palmitate
is: HMDB00220
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
type: Species
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249

http://identifiers.org/biomodels.db/MODEL1310110003#_6c463a0a_b4cb_4093_b4e2_489a9a1c68c2
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is: Q99944
boundary condition: true
name: EGFL8
is encoded by: hsa:80864
type: Species

metaR BILIRUBt2
type: Reaction
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110003#
reversible: true
is described by: ECO:0000269
fast: false
modifier: MODEL1310110003#
is: SBO:0000185
name: bilirubin transport via bicarbonate countertransport

metaR r0413
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
name: dATP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40
product: MODEL1310110003#

metaR r2356
is described by: ECO:0000000
kinetic law: MODEL1310110003#
fast: false
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_dad7f243_8702_425b_95ae_dc725d843f91
is encoded by: hsa:7352
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: UCP3
constant: false
has only substance units: false

metaM malt e
is: C00208
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
constant: false
name: Maltose
initial concentration: 1.0
is: HMDB00163
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:17306
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_4ba4a64b_28a1_4639_9ef1_ac9e03432456
initial concentration: NaN
is encoded by: hsa:2875
initial amount: NaN
constant: false
type: Species
is: P24298
name: GPT
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR r2133
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_b40173bb_1b17_490e_95c4_6f6145ac79c1
has only substance units: false
is: O94903
is: SBO:0000252
initial amount: NaN
name: PROSC
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:11212
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_2015c96b_40ed_40d0_b5e5_553f0f19f8ba
name: ACADVL
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:37
is: P49748

http://identifiers.org/biomodels.db/MODEL1310110003#_080898af_d4fd_41df_9003_81f427c2710c
constant: false
name: HADHB
is encoded by: hsa:3032
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P55084
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_58560f8d_60ea_4442_bd53_eba6ecbfcfb0
is: SBO:0000252
name: PPA1
has only substance units: false
is: Q15181
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5464
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_7395c64c_3f96_458e_b318_37f1053bebc2
type: Species
name: _HG2846_HT2983_1_c
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:HG2846-HT2983

metaR MANtly
is: SBO:0000185
reactant: MODEL1310110003#
reversible: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
type: Reaction
product: MODEL1310110003#
is described by: ECO:0000000
name: mannose efflux from lysosome
fast: false

metaR ALADGLNexR
reversible: true
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110003#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
name: L-alanine/glutamine reversible exchange

http://identifiers.org/biomodels.db/MODEL1310110003#_509d1b5c_2e56_4f32_8c39_7e272482c775
is: SBO:0000252
name: GART
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2618
initial amount: NaN
is: Q59HH3
boundary condition: true
constant: false
type: Species

metaM CE2705 c
boundary condition: false
initial concentration: 1.0
constant: false
name: quinonoid dihydrobiopterin
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:52328
initial amount: NaN
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705

http://identifiers.org/biomodels.db/MODEL1310110003#_2e9f3afd_6deb_454c_b835_7abc783633c1
initial amount: NaN
has only substance units: false
is encoded by: hsa:4514
name: COX3
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: P00414
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_b238e38e_5930_4e1f_b419_c5a247350db4
is: P48448
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: ALDH3B2
is encoded by: hsa:222
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_ab3f7826_5075_4708_b230_577f7cef7f4a
is: Q9NPB1
initial concentration: NaN
is encoded by: hsa:56953
type: Species
is: SBO:0000252
name: NT5M
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true

metaM ksi g
is: CHEBI:57255
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
constant: false
is: SBO:0000247
initial amount: NaN
type: Species
name: keratan sulfate I
initial concentration: 1.0
is: HMDB01014
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_0369ce8a_0bb6_41ea_81fe_f278a10aedd6
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10246
is: O00624
type: Species
boundary condition: true
constant: false
has only substance units: false
name: SLC17A2
initial amount: NaN

metaR PI34P5K
reactant: MODEL1310110003#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
is version of: http://identifiers.org/ec-code/2.7.1.68
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
kinetic law: MODEL1310110003#
reversible: false
modifier: MODEL1310110003#
product: MODEL1310110003#

metaR S6T2g
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000

metaR CMPSAS
type: Reaction
notes: GENE_ASSOCIATION: (55907.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.43 Confidence Level: 2 AUTHORS: PMID:9689047 NOTES:NCD
name: CMP sialic acid synthase
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.7.43
fast: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: false
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000176

metaR CHOLATEt
kinetic law: MODEL1310110003#
is: SBO:0000185
reversible: true
type: Reaction
modifier: MODEL1310110003#
reactant: MODEL1310110003#
name: cholate transport via bicarbonate countertransport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
fast: false
product: MODEL1310110003#

metaR FAOXC140
type: Reaction
product: MODEL1310110003#
is: SBO:0000176
reactant: MODEL1310110003#
name: Beta oxidation of long chain fatty acid
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211

http://identifiers.org/biomodels.db/MODEL1310110003#_ead9258a_c4cc_43cf_ac4f_820e735f422e
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:728226
name: _728226_1_m
constant: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_3b9bafec_0bb5_43cb_960f_fd13972b4a41
is: Q5SYN6
initial concentration: NaN
is encoded by: hsa:6581
boundary condition: true
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: SLC22A3

metaR RETHe
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinyl ester hydrolase, extracellular
fast: false
reactant: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_b97c0e5b_60fb_44bc_a538_49c758b57532
is encoded by: hsa:AI934540
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
constant: false
name: _AI934540_1_c

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_e30edc2c_d9b2_4f1a_a09f_10c3dfd99e46
boundary condition: true
name: HADHA
type: Species
initial concentration: NaN
constant: false
is: E9KL44
is: SBO:0000252
is encoded by: hsa:3030
has only substance units: false
initial amount: NaN

metaR GLYPHEHYc
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
name: hydrolysis of glycylphenylalanine
reactant: MODEL1310110003#
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.

http://identifiers.org/biomodels.db/MODEL1310110003#_6522965b_1e4a_4d89_9668_47aef5ab2b59
boundary condition: true
name: LEFTY1
is: O75610
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:10637

http://identifiers.org/biomodels.db/MODEL1310110003#_5f24de5c_fa9a_412f_ba33_c258137dbfc7
has only substance units: false
boundary condition: true
type: Species
name: ADH6
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:130
is: SBO:0000252
is: P28332

http://identifiers.org/biomodels.db/MODEL1310110003#_d354cb56_1b62_4db8_b065_4e17bac4a0f4
initial amount: NaN
is: Q11203
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:6487
boundary condition: true
name: ST3GAL3
has only substance units: false
initial concentration: NaN

metaR PEPCKm
name: Phosphoenolpyruvate carboxykinase (GTP)
type: Reaction
reversible: false
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.1.1.32
fast: false
is described by: ECO:0000000
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
is: SBO:0000176
modifier: MODEL1310110003#
product: MODEL1310110003#

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaR OAADC
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: oxaloacetate decarboxylase
type: Reaction

metaR DM atp c
is described by: ECO:0000134
is: SBO:0000176
reversible: false
reactant: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
kinetic law: MODEL1310110003#
type: Reaction
name: DM_atp(c)
product: MODEL1310110003#

metaR LSTO1r
kinetic law: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ
is version of: http://identifiers.org/ec-code/1.14.21.6
product: MODEL1310110003#
name: Lathosterol oxidase
is: SBO:0000176
reactant: MODEL1310110003#
reversible: false
type: Reaction
is described by: ECO:0000269

metaM mescon m
is: HMDB00749
constant: false
initial amount: NaN
name: Mesaconate
boundary condition: false
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
has only substance units: false
is: CHEBI:36986
is: SBO:0000247
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_599c3aae_7432_4d16_a5e5_b452f25173e5
name: HMGCS2
initial concentration: NaN
is: P54868
type: Species
constant: false
is encoded by: hsa:3158
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR S6T13g
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
reversible: false
fast: false
modifier: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110003#
type: Reaction
is described by: ECO:0000000

metaR r1380
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:12162789,PMID:9291139,PMID:9638657 NOTES:
reversible: true
name: delta24-sterol reductase Biosynthesis of steroids EC:1.3.1.72
reactant: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110003#
product: MODEL1310110003#

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR r2136
fast: false
reversible: false
is: SBO:0000185
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reactant: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
kinetic law: MODEL1310110003#

metaM hs deg22 l
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
has only substance units: false
boundary condition: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB02704
notes: FORMULA: C37H56NO35S CHARGE: -3
is: CHEBI:21338

metaR r0603
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.12
type: Reaction
reversible: true
fast: false
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
modifier: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_164e7cb2_914d_4a89_92b8_f985e96c003c
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
name: SLC6A10P
has only substance units: false
boundary condition: true
is encoded by: hsa:386757

http://identifiers.org/biomodels.db/MODEL1310110003#_89f9e287_89e3_47ff_9a3c_6d59a360d63b
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: _AI926493_1_c
is encoded by: hsa:AI926493
type: Species
initial concentration: NaN

metaM ksi e
has only substance units: false
is: CHEBI:17268
boundary condition: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
name: keratan sulfate I
initial amount: NaN
initial concentration: 1.0
is: HMDB00211
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_ff0e6797_c740_4bf9_af22_a79372cfa6ae
initial amount: NaN
name: ACSL1
is: SBO:0000252
constant: false
is: P33121
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:2180
initial concentration: NaN

metaR EX arachd LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: nC20:4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_9fa946a7_1aca_4425_ab23_c6dc3be35dbb
is encoded by: hsa:125
initial amount: NaN
has only substance units: false
name: ADH1B
is: P00325
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
boundary condition: true

metaR HS4ly
product: MODEL1310110003#
is: SBO:0000176
fast: false
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
reversible: false
name: heparan-N-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.10.1.1
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
modifier: MODEL1310110003#
is described by: ECO:0000000

metaM CE2838 e
initial amount: NaN
name: maltononaose
has only substance units: false
type: Species
constant: false
is: C01936
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838

metaM dsmsterol r
constant: false
name: desmosterol
is: CHEBI:17737
is: HMDB02719
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00847 EHMN_ABBREVIATION: C01802
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaR ASNtN1
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
name: Asparagine transport (Na, H coupled)
modifier: MODEL1310110003#
reversible: true
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_c9ec2346_a831_490f_b922_870f8f7f0013
name: AMY2A
initial amount: NaN
is encoded by: hsa:279
boundary condition: true
type: Species
has only substance units: false
constant: false
is: P04746
is: SBO:0000252
initial concentration: NaN

metaM sphmyln hs c
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
name: sphingomyelin betaine
has only substance units: false
constant: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:58216

http://identifiers.org/biomodels.db/MODEL1310110003#_97ccfe41_8f34_4c08_8702_3cd72ef78f56
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:954
is: Q5SPY7
name: ENTPD2
boundary condition: true
is: SBO:0000252

metaR r1381
reversible: true
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
reactant: MODEL1310110003#
name: 5alpha-Cholest-7-en-3beta-ol delta7-delta8-isomerase Biosynthesis of steroids EC:5.3.3.5
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_e8a547ba_1109_463f_8418_9ed461d07333
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:6547
name: SLC8A3
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_f2b3f890_0e1e_4d7a_82a2_59bf3bd919fb
type: Species
initial amount: NaN
is: Q16842
has only substance units: false
is: SBO:0000252
is encoded by: hsa:6483
constant: false
name: ST3GAL2
boundary condition: true
initial concentration: NaN

metaR r1650
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110003#
is: SBO:0000185
modifier: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#

metaR ADK1
reversible: true
name: adenylate kinase
is: SBO:0000176
modifier: MODEL1310110003#
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.3
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction

metaR MTHFC
notes: GENE_ASSOCIATION: (4522.1) or (100287639.1) or (441024.1) SUBSYSTEM: Folate metabolism EC Number: 3.5.4.9 Confidence Level: 4 AUTHORS: PMID:2786332 NOTES:Human Y/N: Y
reversible: true
modifier: MODEL1310110003#
name: methenyltetrahydrofolate cyclohydrolase
is version of: http://identifiers.org/ec-code/3.5.4.9
is version of: http://identifiers.org/ec-code/1.5.1.5
product: MODEL1310110003#
fast: false
type: Reaction
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110003#_b2b50e23_06b2_4df3_ad6a_2e61319c061a
is encoded by: hsa:2591
boundary condition: true
type: Species
is: SBO:0000252
name: GALNT3
constant: false
initial amount: NaN
is: Q14435
has only substance units: false
initial concentration: NaN

metaR GGH 10FTHF7GLUe
product: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
fast: false
modifier: MODEL1310110003#
reversible: false
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
kinetic law: MODEL1310110003#

metaR r2137
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
kinetic law: MODEL1310110003#
type: Reaction
fast: false
modifier: MODEL1310110003#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_d0b88b7c_849a_4a9d_9ee8_fee4be72d616
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
constant: false
is encoded by: hsa:8703
is: SBO:0000252
has only substance units: false
is: A8K5Z0
name: B4GALT3

metaM retfa e
is: SBO:0000247
type: Species
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00508
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
has only substance units: false
is: CHEBI:15963
initial concentration: 1.0
name: fatty acid retinol

http://identifiers.org/biomodels.db/MODEL1310110003#_2911d4da_7fcf_4134_86e8_2448dd6045d5
initial concentration: NaN
boundary condition: true
name: CMPK1
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:51727
type: Species
is: B2R6S5
has only substance units: false

metaR 34HPPOR
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110003#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.13.11.27
kinetic law: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
reversible: false

metaM 3hpcoa m
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
constant: false
is: HMDB06807
is: CHEBI:58528
name: 3-hydroxypropanoyl-CoA(4-)
has only substance units: false

metaR r0714
type: Reaction
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reversible: false
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35

http://identifiers.org/biomodels.db/MODEL1310110003#_31de0b48_e761_4c89_925f_f186b5e6ea0e
initial amount: NaN
is: O75489
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
name: NDUFS3
is encoded by: hsa:4722
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_1e1bb88e_4514_48c2_bf24_aaca1f319020
initial amount: NaN
name: ATP2B4
is: P23634
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:493
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR HOMt4
notes: GENE_ASSOCIATION: (6541.1) or (84889.1) or (6542.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
name: L-homoserine via sodium symport
product: MODEL1310110003#
reversible: false
fast: false
reactant: MODEL1310110003#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_4e2d5d09_a292_46db_a107_6ddbf74c4821
initial amount: NaN
is encoded by: hsa:7991
initial concentration: NaN
name: TUSC3
is: SBO:0000252
constant: false
has only substance units: false
type: Species
boundary condition: true

metaR r2508
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
reversible: true
product: MODEL1310110003#
name: Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110003#_d642c00f_21f1_47f1_b2e6_abaf7464d64b
type: Species
name: SLC8A3
initial amount: NaN
is encoded by: hsa:6547
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false

metaM h e
notes: FORMULA: H CHARGE: 1 INCHI: "
constant: false
name: proton
type: Species
is: CHEBI:24636
is: http://identifiers.org/pubchem.compound/3380
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C00080
boundary condition: false

metaR DESAT18 10
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C18:2CoA -> n-C18:3CoA)
reactant: MODEL1310110003#
fast: false
type: Reaction
kinetic law: MODEL1310110003#
reversible: false
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is described by: ECO:0000000
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_4c72ea99_d693_4ecb_8787_5fe60ef06ed5
has only substance units: false
is: Q99798
is encoded by: hsa:50
initial amount: NaN
name: ACO2
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

metaM dgdp m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
constant: false
initial amount: NaN
name: dGDP(2-)
is: HMDB00960
type: Species
boundary condition: false
is: CHEBI:58595

metaR r1167
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.3.1.26 Confidence Level: 0 AUTHORS: PMID:2760547,PMID:7822296,PMID:9242919 NOTES:
product: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
name: EC:2.3.1.26
fast: false
reversible: false
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#

metaR KAS8
name: b-ketoacyl synthetase (palmitate, n-C16:0)
modifier: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
reversible: false
reactant: MODEL1310110003#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
is: SBO:0000176

metaM 2mop m
initial concentration: 1.0
name: 2-methyl-3-oxopropanoate
has only substance units: false
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
initial amount: NaN
boundary condition: false
is: CHEBI:57700
is: HMDB01172

metaR RE0453N
reactant: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
product: MODEL1310110003#
name: RE0453
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
kinetic law: MODEL1310110003#
fast: false

metaM ala L m
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:16977
name: L-alanine
is: SBO:0000247
constant: false
is: HMDB00161
initial amount: NaN
has only substance units: false

metaM hdca r
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
initial concentration: 1.0
has only substance units: false
is: HMDB00220
is: CHEBI:7896
is: SBO:0000247
is: C00249
type: Species
name: Hexadecanoate (n-C16:0)
boundary condition: false
constant: false
initial amount: NaN

metaM h c
is: http://identifiers.org/pubchem.compound/3380
is: C00080
boundary condition: false
notes: FORMULA: H CHARGE: 1 INCHI: "
has only substance units: false
constant: false
type: Species
name: proton
initial amount: NaN
initial concentration: 1.0
is: CHEBI:24636
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_d68cc9dd_931d_4027_a28e_917bf58bd94e
type: Species
is: P23219
has only substance units: false
is encoded by: hsa:5742
boundary condition: true
initial concentration: NaN
constant: false
name: PTGS1
is: SBO:0000252
initial amount: NaN

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaR ADK3
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
modifier: MODEL1310110003#
fast: false
is described by: ECO:0000269
product: MODEL1310110003#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adentylate kinase (GTP)
type: Reaction

metaR r2139
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
modifier: MODEL1310110003#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185
reversible: true
product: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_bb732c74_0d0f_4185_a3c6_ca3184740f5e
initial amount: NaN
name: _AI348006_1_c
boundary condition: true
is encoded by: hsa:AI348006
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species

metaR RE3050R
name: RE3050
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
reversible: true
is: SBO:0000176
reactant: MODEL1310110003#
product: MODEL1310110003#

metaR GALt4
type: Reaction
kinetic law: MODEL1310110003#
name: galactose transport via sodium symport
is described by: ECO:0000269
product: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
is: SBO:0000185
fast: false
reactant: MODEL1310110003#

metaR r2509
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110003#
reactant: MODEL1310110003#
name: Utilized transport
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_86b400d5_52da_4d2c_8db6_21467fbb4a25
initial amount: NaN
is: SBO:0000252
name: NAE1
is encoded by: hsa:8883
boundary condition: true
type: Species
initial concentration: NaN
is: A8MU28
constant: false
has only substance units: false

metaR PROSTGE2t
modifier: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
fast: false
reversible: true
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110003#

metaR G14T10g
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110003#_776524b6_fac6_4e63_b1e4_3524062ae2cc
type: Species
boundary condition: true
has only substance units: false
is: Q99714
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:3028
initial concentration: NaN
name: HSD17B10

http://identifiers.org/biomodels.db/MODEL1310110003#_bc9a2319_1f75_4d2e_a607_3e309b19d11d
is: P12074
constant: false
boundary condition: true
name: COX6A1
initial concentration: NaN
is encoded by: hsa:1337
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN

metaR AG13T2g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
modifier: MODEL1310110003#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110003#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_c722d994_3dbc_47a6_9c46_24aab6a26a44
name: SGSH
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6448
is: P51688
initial amount: NaN
constant: false

metaM dgdp n
is: SBO:0000247
is: HMDB00960
constant: false
boundary condition: false
is: CHEBI:58595
initial amount: NaN
initial concentration: 1.0
name: dGDP(2-)
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
type: Species
has only substance units: false

metaR GCHOLAtx
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
name: bile acid intracellular transport
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
type: Reaction
fast: false
product: MODEL1310110003#

metaR DIDPtn
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
name: dIDP nuclear transport

http://identifiers.org/biomodels.db/MODEL1310110003#_6332a490_17a2_4e7f_86c0_1a895632327b
initial amount: NaN
is encoded by: hsa:3033
constant: false
initial concentration: NaN
name: HADH
type: Species
is: Q16836
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_0e6776e4_0162_4639_9411_02b7d7bd5d1c
constant: false
name: VNN3:VNN2:VNN1
initial concentration: NaN
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:55350
has only substance units: false
boundary condition: true
type: Species

metaM h g
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
is: CHEBI:24636
name: proton
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false

metaR r2506
reversible: true
fast: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
name: Utilized transport

metaM leuktrA4 c
type: Species
name: leukotriene A4(1-)
has only substance units: false
is: SBO:0000247
is: CHEBI:57463
boundary condition: false
is: HMDB01337
initial amount: NaN
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
constant: false
initial concentration: 1.0

metaR PNTOte
is described by: ECO:0000134
type: Reaction
product: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
is: SBO:0000185
name: Transport of (R)-Pantothenate
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_9dfba430_68b1_4fe5_83c6_f0013ceca162
type: Species
is: SBO:0000252
initial concentration: NaN
name: _AI640625_1_c
is encoded by: hsa:AI640625
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

metaR DM anth
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_f3b91493_f258_4447_be91_8db5a3f434dd
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI440329
type: Species
name: _AI440329_1_r
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false

metaM oh1 c
initial concentration: 1.0
name: hydroxide ion
notes: FORMULA: HO CHARGE: -1
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
is: HMDB01039
is: C01328

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaM ksi pre27 g
name: keratan sulfate I biosynthesis, precursor 27
constant: false
boundary condition: false
notes: FORMULA: C205H328N14O171S8X CHARGE: -9
is: CHEBI:58053
is: HMDB00175
is: C00130
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247

metaR UAGDP
type: Reaction
kinetic law: MODEL1310110003#
is: SBO:0000176
modifier: MODEL1310110003#
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.7.23
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:
name: UDP-N-acetylglucosamine diphosphorylase
is described by: ECO:0000269
fast: false
reactant: MODEL1310110003#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110003#_e816b7d1_c962_443d_bd54_ccc3ba866192
is encoded by: hsa:AI469183
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: _AI469183_1_x
initial concentration: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_f34ca4c2_ec1f_4a99_a707_d08372ac1cc2
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: C9JC79
is encoded by: hsa:6342
name: SCP2
boundary condition: true
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_a434363c_195a_4358_b9cc_251ef7d8f2d1
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:51292
name: GMPR2
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaR B3GALT3g
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.79
name: Beta-1,3-galactosyltransferase 3
fast: false
product: MODEL1310110003#
reversible: false
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
kinetic law: MODEL1310110003#
is described by: ECO:0000269
reactant: MODEL1310110003#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_861a9fc8_ef3a_4696_abcd_ed5247bcbf3e
initial amount: NaN
is: P52790
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:3101
name: HK3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_4825e40f_bd16_4340_bb4e_7b80dca78e9b
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:29968
name: PSAT1
is: SBO:0000252

metaR r2507
kinetic law: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110003#
name: Utilized transport
reactant: MODEL1310110003#
reversible: true

metaR ALAt4
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: false
type: Reaction
name: Alanine-Sodium symporter
is: SBO:0000185
fast: false
reactant: MODEL1310110003#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (54407.1) or (6542.1) or (11254.1) or (6541.1) or (81539.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:tv Mendz pg. 201 Reversibility is unclear.
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_579057e9_6fe8_4efd_9d06_2927687d44da
is encoded by: hsa:221
type: Species
constant: false
is: P43353
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ALDH3B1
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_c0d63da4_9f3d_4b8a_98b5_2cd0feba8181
boundary condition: true
is encoded by: hsa:84532
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is: Q9NUB1
initial amount: NaN
name: ACSS1

http://identifiers.org/biomodels.db/MODEL1310110003#_1571dcd9_9242_47fe_941b_b5e13a062974
is encoded by: hsa:51292
name: GMPR2
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is: Q9P2T1
initial concentration: NaN

metaM HC02208 e
name: prostaglandin-d1
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
type: Species
is: CHEBI:27696
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM pail34p hs c
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
is: CHEBI:57658
is: SBO:0000247

metaM leuktrA4 e
type: Species
is: HMDB01337
initial concentration: 1.0
name: leukotriene A4(1-)
initial amount: NaN
is: CHEBI:57463
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
boundary condition: false
constant: false

metaR CDS
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.7.41
reversible: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (1040.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:ER membrane - but on cytosolic surface NJ
modifier: MODEL1310110003#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110003#
type: Reaction
is: SBO:0000176
name: phosphatidate cytidylyltransferase

metaR r2355
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110003#
fast: false
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110003#
reversible: true

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaR r0718
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.181
type: Reaction
fast: false
reversible: false

metaR DCK2n
is described by: ECO:0000269
kinetic law: MODEL1310110003#
is: SBO:0000176
name: Deoxycytidine kinase, nuclear (UTP)
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.1.74
product: MODEL1310110003#

metaR SERHL
reversible: false
fast: false
product: MODEL1310110003#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:2674117 NOTES:MM
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.3.1.17
reactant: MODEL1310110003#
name: L-Serine hydro-lyase
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#

metaM fadh2 r
has only substance units: false
initial concentration: 1.0
is: HMDB01197
constant: false
is: CHEBI:58307
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
name: FADH2(2-)
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR r1163
type: Reaction
fast: false
reversible: false
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
reactant: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15297262 NOTES:
kinetic law: MODEL1310110003#

metaR HISSNAT5tc
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_7ac87ab3_a09f_48b0_99d8_5e45e1c012d6
initial amount: NaN
constant: false
is: Q6LEN5
is encoded by: hsa:1103
name: CHAT
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR H2Oter
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: H2O endoplasmic reticulum transport
product: MODEL1310110003#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR r0083
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
kinetic law: MODEL1310110003#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.42
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
modifier: MODEL1310110003#
type: Reaction
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#

metaR r0940
name: Free diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
fast: false
reactant: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_2e999e70_a458_4289_962a_786220bd4bbe
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:3156
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P04035
name: HMGCR
type: Species

metaM for r
has only substance units: false
type: Species
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
boundary condition: false
initial concentration: 1.0
is: HMDB00142
initial amount: NaN
is: SBO:0000247
is: CHEBI:15740
constant: false
is: C00058
name: Formate

metaR r0941
product: MODEL1310110003#
is described by: ECO:0000000
fast: false
type: Reaction
name: Free diffusion
kinetic law: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:

metaR r2354
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
reversible: true
kinetic law: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110003#
reactant: MODEL1310110003#
fast: false

metaR FOLTle
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: folate uptake into the enterocytes
type: Reaction

metaM prostge1 e
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: CHEBI:57397
initial amount: NaN
type: Species
name: prostaglandin E1(1-)
is: HMDB01442
constant: false
initial concentration: 1.0

metaM HC02208 c
name: prostaglandin-d1
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
type: Species
is: CHEBI:27696
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_208fd7b0_a84d_4c6c_ae13_7824f0092d09
boundary condition: true
is encoded by: hsa:6487
name: ST3GAL3
is: Q96L53
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

metaM oh1 e
is: SBO:0000247
is: HMDB01039
boundary condition: false
is: C01328
initial concentration: 1.0
constant: false
name: hydroxide ion
initial amount: NaN
notes: FORMULA: HO CHARGE: -1
has only substance units: false
type: Species

metaR ASPPROASCT1
fast: false
is: SBO:0000185
is described by: ECO:0000134
name: aspartate intake by system ASCT-1 transporter
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (6509.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 14502423, PMID: 11824937, Kim E. Barrett, Mark Donowitz (2001) Gastrointestinal transport: Molecular physiology, Academic press, A harcourt science and technology company, chapter 10, pages 389-391. NOTES:ASCT-1 transport system operates at the basolateral surface, acts as an amino acid exchanger. Preferred substrates are small neutral amino acids, however shown to have transport proline and hydroxy-proline. At acidic ph also transports aspartate and glutamate. the ASCT-1 operates in a similar mechanism as ASCT-2.
reversible: false
modifier: MODEL1310110003#

metaM 3aib D c
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
constant: false
boundary condition: false
is: C03265
is: HMDB02299
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: D-3-Amino-isobutanoate

metaM 3hmbcoa m
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01356
is: CHEBI:57312
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
constant: false
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
type: Species
initial amount: NaN
initial concentration: 1.0

metaR r0345
fast: false
type: Reaction
is described by: ECO:0000000
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
kinetic law: MODEL1310110003#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.13
modifier: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110003#_1404925c_e3f8_4248_b8b1_e4c8f6734437
is: SBO:0000252
has only substance units: false
name: ST3GAL3
boundary condition: true
type: Species
constant: false
is encoded by: hsa:6487
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_4c1b92c1_ebc8_4420_864e_6ff49c5d4923
constant: false
initial concentration: NaN
is: P31350
has only substance units: false
name: RRM2
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:6241
boundary condition: true

metaR r2353
name: Organic anion transporter 5 Utilized transport
fast: false
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_e774cc4a_8fd5_4154_8982_7cd32b408705
constant: false
name: SLC26A6
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:65010
is: Q548A7
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

metaR G16MT U
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110003#_b267065c_905a_4e39_b246_d586eb87d0b5
type: Species
is encoded by: hsa:197257
has only substance units: false
is: SBO:0000252
name: LDHD
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: Q86WU2

metaM 34dhpac c
type: Species
notes: FORMULA: C8H8O3 CHARGE: 0 INCHI: InChI=1S/C8H8O3/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,4-5,10-11H,3H2 EHMN_ABBREVIATION: C04043
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:27978
is: HMDB03791
has only substance units: false
initial amount: NaN
name: 3,4-Dihydroxyphenylacetaldehyde
is: SBO:0000247

metaR r0716
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reactant: MODEL1310110003#
product: MODEL1310110003#
kinetic law: MODEL1310110003#

metaR M13N2Tg
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.101
modifier: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_8b531458_296f_4227_873b_a95931061790
is: SBO:0000252
type: Species
initial concentration: NaN
is: B3KNC1
name: UPB1
is encoded by: hsa:51733
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

metaM n2m2nmn l
initial concentration: 1.0
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
initial amount: NaN
is: HMDB00939
is: CHEBI:16680
boundary condition: false
type: Species
notes: FORMULA: C50H84N4O36 CHARGE: 0
constant: false
is: SBO:0000247
has only substance units: false

metaR O2t
name: o2 transport (diffusion)
kinetic law: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
reversible: true
fast: false
reactant: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_85e4d864_a68a_4e3d_a629_5ef2db707b69
is: SBO:0000252
is: P35219
constant: false
boundary condition: true
is encoded by: hsa:767
initial concentration: NaN
type: Species
initial amount: NaN
name: CA8
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_5dbe07ad_6d05_413c_8c5b_bbea108efe9e
is encoded by: hsa:50614
boundary condition: true
initial concentration: NaN
is: Q9HCQ5
is: SBO:0000252
name: GALNT9
constant: false
has only substance units: false
type: Species
initial amount: NaN

metaM pchol hs c
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
is: CHEBI:16110
has only substance units: false
is: SBO:0000247
name: Phosphatidylcholine

metaR OMPDC
reactant: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.10
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
is: SBO:0000176
fast: false
modifier: MODEL1310110003#
reversible: false
is described by: ECO:0000269
name: orotidine-5'-phosphate decarboxylase
product: MODEL1310110003#
kinetic law: MODEL1310110003#

metaR CGLYt3 2
kinetic law: MODEL1310110003#
name: Cys-Gly transport in via proton symport
fast: false
reactant: MODEL1310110003#
type: Reaction
is: SBO:0000185
is described by: ECO:0000304
reversible: false
product: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB

metaR RE1796M
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
product: MODEL1310110003#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.145
fast: false
type: Reaction
modifier: MODEL1310110003#
name: RE1796
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000

metaR r0157
product: MODEL1310110003#
fast: false
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/6.3.4.2
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
modifier: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
reactant: MODEL1310110003#
is described by: ECO:0000000

metaM g2m8masn r
boundary condition: false
notes: FORMULA: C82H137N2O65X CHARGE: 0
type: Species
initial concentration: 1.0
is: C05874
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)

http://identifiers.org/biomodels.db/MODEL1310110003#_71970971_dba8_4257_aae9_cef7aa088a28
is: Q8NFF5
name: FLAD1
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:80308
initial concentration: NaN
boundary condition: true

metaR r0410
is: SBO:0000176
reversible: true
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
reactant: MODEL1310110003#
product: MODEL1310110003#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction

metaR r2352
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
product: MODEL1310110003#
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false

metaR r2465
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12748859 NOTES:
reactant: MODEL1310110003#
fast: false
type: Reaction
name: Cation Diffusion Facilitator (CDF) TCDB:2.A.4.2.3
product: MODEL1310110003#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000

metaR CSND
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
reactant: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#
is described by: ECO:0000000
fast: false
type: Reaction
name: Cytosine deaminase
kinetic law: MODEL1310110003#
reversible: false

metaR AHCYStr
fast: false
is: SBO:0000185
product: MODEL1310110003#
is described by: ECO:0000000
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
type: Reaction
reversible: true
name: S-Adenosyl-L-homocysteine intracellular diffusion

metaR RE1526M
type: Reaction
reactant: MODEL1310110003#
name: RE1526
product: MODEL1310110003#
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is: SBO:0000176

metaM prostge1 c
boundary condition: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
is: SBO:0000247
is: CHEBI:57397
name: prostaglandin E1(1-)
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01442
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_bc9e37da_4714_4f39_8d48_f8b053e4ed9d
type: Species
constant: false
name: AK4
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:205

metaR GLUDxm
type: Reaction
reactant: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.4.1.3
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
name: glutamate dehydrogenase (NAD) (mitochondrial)

metaR ARGLYSex
modifier: MODEL1310110003#
is described by: ECO:0000269
reactant: MODEL1310110003#
type: Reaction
name: Arginine/Lysine exchanger (Arg in)
product: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
fast: false
reversible: false
is: SBO:0000185

metaR XYLt
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
modifier: MODEL1310110003#
name: D-xylose reversible transport
fast: false
kinetic law: MODEL1310110003#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269

metaR RE3624M
modifier: MODEL1310110003#
is described by: ECO:0000000
name: RE3624
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
type: Reaction
product: MODEL1310110003#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.6
is: SBO:0000176
reactant: MODEL1310110003#

metaM glu L e
has only substance units: false
type: Species
constant: false
is: HMDB00148
name: L-glutamate(1-)
is: CHEBI:29985
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H8NO4 CHARGE: -1 INCHI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00034 EHMN_ABBREVIATION: C00025
is: SBO:0000247

metaM arachcoa m
is: SBO:0000247
name: arachidyl coenzyme A
constant: false
type: Species
is: CHEBI:15527
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB04258
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041

metaR r0130
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
reversible: true
product: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
kinetic law: MODEL1310110003#
type: Reaction

metaR IMPC
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
reversible: true
type: Reaction
modifier: MODEL1310110003#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.3
kinetic law: MODEL1310110003#
is described by: ECO:0000269
product: MODEL1310110003#
name: IMP cyclohydrolase
reactant: MODEL1310110003#

metaR r0156
reversible: false
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is version of: http://identifiers.org/ec-code/2.7.1.40
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
kinetic law: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
product: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
is: SBO:0000176

metaR r0082
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.2
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (2875.1) or (84706.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:
kinetic law: MODEL1310110003#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
type: Reaction

metaR ILEt5m
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
name: Isoleucine mitochondrial transport

metaM strch1 e
is: CHEBI:456215
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]})
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C66H112O56 CHARGE: 0
has only substance units: false
is: SBO:0000247
is: C00020
is: HMDB00045
boundary condition: false
initial concentration: 1.0

metaM 4abutn e
type: Species
boundary condition: false
is: CHEBI:58264
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
constant: false
is: HMDB01080
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: 4-ammoniobutanal

metaR DGK1
product: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.8
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110003#
type: Reaction
is described by: ECO:0000269
name: deoxyguanylate kinase (dGMP:ATP)
kinetic law: MODEL1310110003#

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_3bdab5c6_813d_489e_8ab8_f975f27f1658
is encoded by: hsa:6647
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P00441
type: Species
name: SOD1
initial amount: NaN
boundary condition: true

metaM leuktrD4 c
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: SBO:0000247
name: Leukotriene D4
type: Species
is: CHEBI:28666
is: HMDB03080

metaR CBR2
product: MODEL1310110003#
reactant: MODEL1310110003#
reversible: false
fast: false
modifier: MODEL1310110003#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (873.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.197 Confidence Level: 4 AUTHORS: PMID:8740524,PMID:9740676 NOTES:multiple EC EC 1.1.1.189 EC 1.1.1.197 NJ
name: Carbonyl reductase [NADPH] 1
is version of: http://identifiers.org/ec-code/1.1.1.189
kinetic law: MODEL1310110003#

metaR r0340
type: Reaction
fast: false
product: MODEL1310110003#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.1.38
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110003#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
reversible: false
modifier: MODEL1310110003#
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_bfb0a675_649c_40fe_9273_179a75754433
has only substance units: false
is: SBO:0000252
name: NDUFAB1
is encoded by: hsa:4706
is: O14561
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN

metaM xol27oh r
type: Species
is: CHEBI:17703
initial concentration: 1.0
name: 26-hydroxycholesterol
is: HMDB02103
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN

metaM asn L e
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
is: CHEBI:17196
name: L-asparagine
initial concentration: 1.0
is: HMDB00168
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247

metaR PNTEH
is: SBO:0000176
reactant: MODEL1310110003#
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.5.1.92
reversible: false
fast: false
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
modifier: MODEL1310110003#
name: Hydrolase Class ( RXN R02973)

metaM ala L e
boundary condition: false
is: HMDB00161
constant: false
has only substance units: false
is: CHEBI:16977
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
type: Species
name: L-alanine

http://identifiers.org/biomodels.db/MODEL1310110003#_92150b11_df77_4f31_b019_56db31a93285
type: Species
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:57379
is: SBO:0000252
name: AICDA
boundary condition: true
is: Q546Y9

http://identifiers.org/biomodels.db/MODEL1310110003#_2c86c0b6_e56a_400d_8f74_973467546fcf
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:6567
name: SLC16A2
is: P36021
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_df013071_c489_4598_b93f_9bd755fdb955
boundary condition: true
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:10317
initial amount: NaN
name: B3GALT5
has only substance units: false

metaR NDPK2n
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
modifier: MODEL1310110003#
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000269

metaM ksii core2 pre3 g
notes: FORMULA: C47H76N4O33X CHARGE: -1
constant: false
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 3
is: SBO:0000247
is: C00130
is: HMDB00175
is: CHEBI:58053
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species

metaR r0932
name: Transport reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaR LDH L
modifier: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.27
kinetic law: MODEL1310110003#
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
name: L-lactate dehydrogenase
product: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#

metaR r1659
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110003#
reversible: true
product: MODEL1310110003#
is described by: ECO:0000000

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_ea48dd3e_2db0_4fbc_b67f_af7a7e5296f1
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
name: SLC17A4
is: Q9Y2C5
is encoded by: hsa:10050

metaR HSD3A2r
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
type: Reaction
fast: false
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.1.225
is: SBO:0000176
reactant: MODEL1310110003#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_9a86a40a_dc06_4cd7_abf0_6e85af681168
name: _AI769281_1_e
has only substance units: false
is encoded by: hsa:AI769281
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

metaM nicrnt c
is: C01185
is: CHEBI:57502
is: HMDB01132
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
name: Nicotinate D-ribonucleotide
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
constant: false

metaR r0074
is: SBO:0000176
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/6.2.1.1
is described by: ECO:0000000
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
kinetic law: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_5e6ea1a7_f8b1_4f27_91ba_901530c1e019
is encoded by: hsa:6391
initial amount: NaN
has only substance units: false
name: SDHA:SDHB:SDHC:SDHD
has part: Q99643
is encoded by: hsa:6390
boundary condition: true
is encoded by: hsa:6392
has part: P31040
has part: P21912
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:6389
constant: false
has part: O14521
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_4acd6554_7980_432b_8a69_b6f07360f3f4
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: MTMR6
type: Species
initial concentration: NaN
is: Q9Y217
is encoded by: hsa:9107
has only substance units: false

metaR TSTSTERONEtr
type: Reaction
product: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
name: testosterone intracellular transport
reversible: true
kinetic law: MODEL1310110003#

metaR r1598
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110003#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaM 10fthf m
is: HMDB00972
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
name: 10-formyltetrahydrofolate(2-)
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454

metaR GLCter
name: glucose transport, endoplasmic reticulum
kinetic law: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110003#_63e30f35_d936_44b1_a8aa_ee4a8dea9e8d
name: IMPA1
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is: B7Z6Q4
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:3612

metaM dgdp c
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:58595
is: SBO:0000247
is: C00361
initial concentration: 1.0
is: HMDB00960
initial amount: NaN
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
name: dGDP

metaR r0931
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
name: Transport reaction
kinetic law: MODEL1310110003#
fast: false
reversible: false
product: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110003#

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

metaM Lpipecol x
type: Species
is: SBO:0000247
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
initial amount: NaN
initial concentration: 1.0
is: CHEBI:30913
name: L-pipecolic acid
boundary condition: false
has only substance units: false
is: HMDB00716
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_d0efb40a_224d_477c_b30c_d330f2f860c8
is: P42765
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: ACAA2
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:10449
constant: false

metaM 3mop c
name: 3-methyl-2-oxopentanoate
has only substance units: false
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
boundary condition: false
is: SBO:0000247
is: HMDB00491
type: Species
initial amount: NaN
is: CHEBI:28654
initial concentration: 1.0
constant: false

metaM CE2705 n
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
is: CHEBI:15374
constant: false
is: SBO:0000247
is: HMDB02281
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: quinonoid dihydrobiopterin

metaR 4ABUTtcn
is: SBO:0000185
reversible: false
is described by: ECO:0000134
product: MODEL1310110003#
name: transport of GABA
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.
reactant: MODEL1310110003#
fast: false
type: Reaction

metaM ala L c
constant: false
is: HMDB00161
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:16977
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
name: L-alanine
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_92184af8_28a7_4d16_a252_889fac2f1a2b
has part: O95497
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:8876
name: VNN3:VNN2:VNN1
is encoded by: hsa:55350
boundary condition: true
is encoded by: hsa:8875
constant: false
has only substance units: false
initial concentration: NaN
type: Species
has part: A8K7W0

metaR r1599
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110003#
type: Reaction

metaR DMATTx
is: SBO:0000176
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.5.1.1
modifier: MODEL1310110003#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (2224.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.1 Confidence Level: 4 AUTHORS: PMID:8188698 NOTES:peroxisomal version - NJ
name: dimethylallyltranstransferase

http://identifiers.org/biomodels.db/MODEL1310110003#_f48521dc_38ec_4229_b209_04b49a5d707c
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:34
is: P11310
name: ACADM
initial amount: NaN
type: Species

metaM ksi pre33 g
initial concentration: 1.0
type: Species
is: HMDB00175
boundary condition: false
is: C00130
constant: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 33
initial amount: NaN
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_5fff715b_32af_4537_9995_cd1a536d93bd
initial concentration: NaN
name: SLC8A3
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:6547
constant: false
is: SBO:0000252
initial amount: NaN

metaR DNDPt22m
name: dTDP transport via dUDP antiport
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110003#
is described by: ECO:0000269
product: MODEL1310110003#
reactant: MODEL1310110003#
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_4055ea89_6633_4293_a4f6_bd96f5b2b11d
initial amount: NaN
boundary condition: true
name: GCNT4
is: SBO:0000252
is encoded by: hsa:51301
is: Q9P109
has only substance units: false
initial concentration: NaN
type: Species
constant: false

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_5df7daf6_c66e_4ddf_9e0a_6271e2ce2384
boundary condition: true
is: O60331
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:23396
has only substance units: false
constant: false
name: PIP5K1C
is: SBO:0000252

metaR GTHDH
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15970797,PMID:16399380 NOTES:NCD. activity catalyzed by GSTO2-2
reversible: false
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
name: Glutathione dehydrogenase (dehydroascorbate reductase)
fast: false
is described by: ECO:0000134
product: MODEL1310110003#
type: Reaction
is: SBO:0000176

metaR CYTK5n
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
kinetic law: MODEL1310110003#
is described by: ECO:0000269
name: cytidylate kinase (CMP),nuclear
type: Reaction
product: MODEL1310110003#
modifier: MODEL1310110003#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_a529c145_e675_4747_a021_72317aaa6333
name: PRPS2
type: Species
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:5634
is: SBO:0000252
is: P11908

metaM 5forthf c
name: 5-Formiminotetrahydrofolate
is: HMDB01534
constant: false
type: Species
is: C00664
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57456
initial amount: NaN
notes: FORMULA: C20H22N8O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00483 EHMN_ABBREVIATION: C00664
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_174128a1_6f00_43fa_b824_3b1c8462530e
initial amount: NaN
name: SLC6A9
type: Species
boundary condition: true
is: P48067
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6536

http://identifiers.org/biomodels.db/MODEL1310110003#_1a411c82_83cf_4be9_97ca_997ad6c8da45
type: Species
initial concentration: NaN
is encoded by: hsa:3030
boundary condition: true
constant: false
is: E9KL44
name: HADHA
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR r1596
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#

metaR UGLCNACtg
name: UDP-GlcNAc Golgi transport via CMP antiport
type: Reaction
reversible: true
modifier: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (11046.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15082721,PMID:15607426 NOTES:NCD
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_6e32045a_4ff1_4b76_b24b_bdf7239a70f4
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4357
type: Species
has only substance units: false
initial amount: NaN
is: P25325
constant: false
name: MPST

metaR PNTK
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110003#
name: pantothenate kinase
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.33
product: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
fast: false
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_cb9dacb2_ba7d_4dbf_b7bd_9964ee42ea1d
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
name: LALBA
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:3906
is: P00709

metaM itp e
is: HMDB00189
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial amount: NaN
has only substance units: false
is: CHEBI:57614
is: SBO:0000247
boundary condition: false
name: ITP(3-)

metaR EX malcoa LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: malonyl-CoA(4-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_a814b655_c748_489e_a3e0_13f3cd00b54e
is: P14920
name: DAO
is encoded by: hsa:1610
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR FAS120COA
kinetic law: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.85
name: fatty-acyl-CoA synthase (n-C12:0CoA)
fast: false
product: MODEL1310110003#
is described by: ECO:0000269
modifier: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction

metaR r0937
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Transport reaction
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110003#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_966242d8_83a8_4585_9c61_5d727243a382
is: SBO:0000252
boundary condition: true
name: B3GNT8
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:374907
is: Q7Z7M8

metaR SUCCt2m
kinetic law: MODEL1310110003#
type: Reaction
name: succinate transport, mitochondrial
is: SBO:0000185
reactant: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
product: MODEL1310110003#
fast: false
modifier: MODEL1310110003#

metaM glyc m
is: C00116
is: HMDB00131
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial amount: NaN
type: Species
is: CHEBI:17754
name: Glycerol
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM CE2250 e
constant: false
notes: FORMULA: C43H72N7O18P3S CHARGE: -4 INCHI: InChI=1S/C43H76N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-31(51)26-34(53)72-25-24-45-33(52)22-23-46-41(56)38(55)43(2,3)28-65-71(62,63)68-70(60,61)64-27-32-37(67-69(57,58)59)36(54)42(66-32)50-30-49-35-39(44)47-29-48-40(35)50/h29-30,32,36-38,42,54-55H,4-28H2,1-3H3,(H,45,52)(H,46,56)(H,60,61)(H,62,63)(H2,44,47,48)(H2,57,58,59)/t32-,36-,37-,38+,42-/m1/s1 EHMN_ABBREVIATION: CE2250
is: SBO:0000247
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:52328
name: 3-oxodocosanoyl-CoA
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_9842cc8c_7009_42cd_b572_b5419fd6a086
has only substance units: false
type: Species
initial concentration: NaN
name: _7359_1_c
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:7359

metaR CYTK1
fast: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110003#
reactant: MODEL1310110003#
name: cytidylate kinase (CMP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM h x
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/3380
name: proton
type: Species
initial amount: NaN
is: C00080

http://identifiers.org/biomodels.db/MODEL1310110003#_bdc0a76b_56e3_4742_a3a4_e4a41e1be252
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q99884
name: SLC6A7
type: Species
constant: false
is encoded by: hsa:6534
boundary condition: true

metaR r1597
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_688be898_a8d9_4f60_9688_58da19fed4fb
has only substance units: false
is: SBO:0000252
name: MLYCD
boundary condition: true
type: Species
initial concentration: NaN
is: O95822
is encoded by: hsa:23417
initial amount: NaN
constant: false

metaM cgly e
is: SBO:0000247
is: HMDB00078
initial amount: NaN
is: CHEBI:4047
initial concentration: 1.0
type: Species
name: L-cysteinylglycine
boundary condition: false
constant: false
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_edbe0522_479b_427d_b7d2_b0a199f74319
initial amount: NaN
type: Species
has only substance units: false
name: PRDX3
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:10935
boundary condition: true
is: E9PH29

metaR GAO1g
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
reversible: false
name: Ganglioside O-acetylation
product: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
modifier: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110003#_b7dcff85_6f94_42a3_b0eb_998e313e61fc
is encoded by: hsa:4702
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: NDUFA8
type: Species
is: B1AM93
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_2c8ddb2e_73ca_46f0_abfc_4f5df35e0ef8
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

metaM 3uib c
initial concentration: 1.0
is: CHEBI:1670
initial amount: NaN
name: 3-Ureidoisobutyrate
constant: false
has only substance units: false
notes: FORMULA: C5H9N2O3 CHARGE: -1 INCHI: InChI=1S/C5H10N2O3/c1-3(4(8)9)2-7-5(6)10/h3H,2H2,1H3,(H,8,9)(H3,6,7,10) HEPATONET_1.0_ABBREVIATION: HC01371 EHMN_ABBREVIATION: C05100
is: SBO:0000247
type: Species
is: HMDB02031
boundary condition: false

metaM m6mpdol U r
type: Species
is: CHEBI:37635
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C1605H2640N20O520P20 CHARGE: -20

http://identifiers.org/biomodels.db/MODEL1310110003#_ce2072a6_cf3e_4640_8a3f_1ceeb5574085
constant: false
boundary condition: true
is: P07205
is encoded by: hsa:5232
initial amount: NaN
name: PGK2
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR r0722
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
fast: false
modifier: MODEL1310110003#
reactant: MODEL1310110003#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/4.2.3.12
is: SBO:0000176
product: MODEL1310110003#
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_7662ba2c_fb5e_4059_a16f_931a7597c5ab
is encoded by: hsa:8704
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
name: B4GALT2
is: SBO:0000252
has only substance units: false
constant: false

metaR r0936
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Transport reaction
reversible: false
reactant: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#
fast: false
is described by: ECO:0000000
type: Reaction

metaM HC00900 c
initial concentration: 1.0
is: CHEBI:30860
name: Methylmalonate
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false

metaR ARACHt
reactant: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: fatty acid transport via diffusion
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: true

metaR FAOXC1811603m
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
is: SBO:0000176
name: Beta oxidation fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110003#

metaR CYTK2
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
modifier: MODEL1310110003#
name: cytidylate kinase (dCMP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110003#
is: SBO:0000176

metaR GLUTCOADHm
reversible: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
name: glutaryl-CoA dehydrogenase (mitochondria)
is: SBO:0000176
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.3.99.7
fast: false
type: Reaction
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#

metaR GCC2cm
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
kinetic law: MODEL1310110003#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.4.4.2
is: SBO:0000176
name: glycine-cleavage complex (lipoamide), mitochondrial
product: MODEL1310110003#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_ff78bac6_4264_45c0_8cdc_703736935a7a
is: Q07837
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6519
is: SBO:0000252
type: Species
name: SLC3A1

metaR SERPT
is: SBO:0000176
fast: false
reactant: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.50
kinetic law: MODEL1310110003#
reversible: false
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
modifier: MODEL1310110003#
name: serine C-palmitoyltransferase

metaR r1594
reversible: true
reactant: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110003#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_d519c73c_9989_4f0d_af4b_671621e61c45
is: Q8TD20
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
name: SLC2A12
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:154091

metaR SCPx
name: peroxisomal thiolase 2
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:SCP has two transcripts, second isoform specific to peroxisomes, first is specific for cyt and mit need to double check stoichiometry - reaction cofactors (additional coa + release of prop coa) from BM (Roche) Biochemical Pathways NJ
is described by: ECO:0000269
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110003#
product: MODEL1310110003#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.176

metaM itp c
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
has only substance units: false
type: Species
is: HMDB00189
constant: false
is: CHEBI:57614
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: ITP(3-)
initial concentration: 1.0

metaR EX retinol LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinol exchange
type: Reaction

metaR LNLNCGt
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion

metaR BHBtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#
reversible: true
type: Reaction
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_114fecfc_b877_4d3d_b049_952364838bee
name: PANK1
type: Species
is encoded by: hsa:53354
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: Q8TE04
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_6ca1454d_b61b_4146_8983_0f4cecbc3985
initial amount: NaN
is encoded by: hsa:30
initial concentration: NaN
has only substance units: false
name: ACAA1
is: Q96CA6
type: Species
constant: false
is: SBO:0000252
boundary condition: true

metaM CE0785 m
has only substance units: false
initial concentration: 1.0
is: CHEBI:57795
name: cis,cis-myristo-5,8-dienoyl-CoA
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
type: Species

metaR DCMPDA
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true
is: SBO:0000176
type: Reaction
fast: false
name: dCMP deaminase
is version of: http://identifiers.org/ec-code/3.5.4.12
is described by: ECO:0000254
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD

metaM dpcoa m
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 3'-dephospho-CoA(2-)
type: Species
constant: false
is: SBO:0000247
is: CHEBI:57328
is: HMDB01373
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
initial amount: NaN

metaM ksi pre19 g
constant: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 19
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: C00130
is: CHEBI:58053
is: SBO:0000247
notes: FORMULA: C171H275N12O137S5X CHARGE: -6

metaR DOLPMT U
type: Reaction
product: MODEL1310110003#
reversible: false
modifier: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.83
is: SBO:0000176
name: Dolichyl-phosphate D-mannosyltransferase (uterus)

metaR ACGAM6PSi
reactant: MODEL1310110003#
product: MODEL1310110003#
fast: false
type: Reaction
name: N-acetylglucosamine-6-phosphate synthase
is version of: http://identifiers.org/ec-code/2.3.1.4
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (64841.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.3.1.4 Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: false
is described by: ECO:0000304

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaR r1595
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110003#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110003#
product: MODEL1310110003#
fast: false

metaM cgly c
is: SBO:0000247
is: HMDB00078
is: CHEBI:4047
initial concentration: 1.0
name: L-cysteinylglycine
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_8bfd7901_e76c_4d80_9bbc_07cefdee72d6
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
name: _AA502753_1_m
is encoded by: hsa:AA502753
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_d468f13c_c511_47ee_89c4_a8c968f0e0a2
boundary condition: true
is: Q6IBA0
initial amount: NaN
has only substance units: false
name: NDUFS5
is: SBO:0000252
is encoded by: hsa:4725
type: Species
initial concentration: NaN
constant: false

metaR RE2649C
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.2
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
is described by: ECO:0000000
reversible: true
name: RE2649
modifier: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.65
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_689a34eb_5347_4b33_b55e_d6f8a791902b
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is: P49327
name: FASN
boundary condition: true
is encoded by: hsa:2194
initial concentration: NaN

metaR r0720
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
reversible: false
fast: false
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_eddafa59_0579_4988_80ab_07740362f03a
name: SDHA
initial concentration: NaN
is: P31040
type: Species
is encoded by: hsa:6389
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false

metaR CO2ter
kinetic law: MODEL1310110003#
name: CO2 endoplasmic reticular transport via diffusion
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110003#
product: MODEL1310110003#
fast: false
reversible: true

metaM 3mb2coa m
boundary condition: false
is: CHEBI:57344
name: 3-methylbut-2-enoyl-CoA(4-)
is: SBO:0000247
initial concentration: 1.0
is: HMDB01493
has only substance units: false
constant: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_059ddbea_8036_4254_94f1_77041759fb51
type: Species
is: Q9Y666
is: SBO:0000252
constant: false
is encoded by: hsa:10723
initial concentration: NaN
boundary condition: true
has only substance units: false
name: SLC12A7
initial amount: NaN

metaR r1717
product: MODEL1310110003#
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#
reversible: false
is: SBO:0000185
modifier: MODEL1310110003#

metaM 3aib D m
has only substance units: false
initial concentration: 1.0
is: HMDB02299
is: C03265
type: Species
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
initial amount: NaN
is: SBO:0000247
name: D-3-Amino-isobutanoate
boundary condition: false

metaR r0934
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
fast: false
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3

metaM ksi pre32 g
is: CHEBI:28067
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 32
notes: FORMULA: C227H362N16O192S10X CHARGE: -11

metaR r0139
type: Reaction
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
modifier: MODEL1310110003#
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110003#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_b985e392_7688_45d2_b2bd_fa28933f21a4
type: Species
initial amount: NaN
is: O94777
name: DPM2
has only substance units: false
is encoded by: hsa:8818
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR r0829
modifier: MODEL1310110003#
product: MODEL1310110003#
reversible: true
is version of: http://identifiers.org/ec-code/4.1.1.37
fast: false
is: SBO:0000185
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110003#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_55b58e1e_a30f_40a4_8d9b_bc5777529489
constant: false
has only substance units: false
initial concentration: NaN
is: Q6IBB5
type: Species
is: SBO:0000252
is encoded by: hsa:4694
initial amount: NaN
boundary condition: true
name: NDUFA1

metaM stcoa m
name: Stearoyl-CoA (n-C18:0CoA)
constant: false
type: Species
initial concentration: 1.0
is: HMDB01114
initial amount: NaN
is: C00412
is: SBO:0000247
is: CHEBI:57394
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
has only substance units: false
boundary condition: false

metaM m7mpdol U r
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:37636
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
initial concentration: 1.0
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
constant: false
has only substance units: false

metaM CE5101 m
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
constant: false
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:57795

metaR r0614
reactant: MODEL1310110003#
fast: false
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
product: MODEL1310110003#
is described by: ECO:0000000
kinetic law: MODEL1310110003#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_e864197c_9011_422c_8759_9a138c044744
constant: false
has only substance units: false
boundary condition: true
name: VNN2
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is: O95498
is encoded by: hsa:8875

metaM 4abutn m
boundary condition: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
has only substance units: false
name: 4-ammoniobutanal
is: CHEBI:58264
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB01080
constant: false

metaR AG13T9g
fast: false
is described by: ECO:0000000
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is: SBO:0000176
product: MODEL1310110003#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR KSIt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: keratan sulfate I transport, golgi to extracellular
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110003#
is described by: ECO:0000000
reversible: false

metaR r1652
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110003#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is: SBO:0000185
product: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
modifier: MODEL1310110003#

metaR r0560
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
fast: false
is: SBO:0000176
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
reversible: false
type: Reaction
product: MODEL1310110003#
is described by: ECO:0000000

metaR r1592
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110003#
fast: false
is: SBO:0000185
type: Reaction

metaM orot c
initial amount: NaN
name: Orotate
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
is: C00295
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:30839
is: HMDB00226

metaM dctp n
is: HMDB00998
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
is: CHEBI:16311
name: dCTP
boundary condition: false
constant: false
is: C00458
initial concentration: 1.0

metaR CYTK6
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
type: Reaction
kinetic law: MODEL1310110003#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is: SBO:0000176
name: cytidylate kinase (CMP,CTP)
reactant: MODEL1310110003#
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_94f14c0e_27be_4395_b2bd_2b6ad84bac0d
is: B7Z792
boundary condition: true
initial concentration: NaN
name: NDUFS2
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:4720

metaR MALTe
is: SBO:0000176
product: MODEL1310110003#
reversible: false
name: alpha-glucosidase, extracellular
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.20
is described by: ECO:0000269
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
fast: false
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_4a00c4f4_b07b_4c72_88eb_a04510961713
is encoded by: hsa:204
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: AK2

http://identifiers.org/biomodels.db/MODEL1310110003#_eb49c093_fca2_4316_b776_f5698d5e1c26
is: SBO:0000252
name: SLC36A1
constant: false
boundary condition: true
is: Q1LZ56
type: Species
is encoded by: hsa:206358
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM 5thf e
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C39H45N11O18 CHARGE: -6
name: pentaglutamyl folate (THF)
type: Species
is: HMDB06487

metaM 13dpg c
name: 3-Phospho-D-glyceroyl phosphate
is: C00236
is: http://identifiers.org/pubchem.compound/3535
is: HMDB01270
constant: false
type: Species
initial concentration: 1.0
is: CHEBI:57604
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236

metaM retinal cis 9 c
has only substance units: false
name: all-trans-retinal
constant: false
is: HMDB01358
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
is: CHEBI:17898
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0

metaM e4p c
has only substance units: false
initial concentration: 1.0
is: CHEBI:16897
constant: false
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB01321
boundary condition: false
name: D-Erythrose 4-phosphate
is: C00279

metaM 3hibutcoa m
is: HMDB01052
has only substance units: false
initial amount: NaN
is: CHEBI:28259
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
name: (S)-3-Hydroxyisobutyryl-CoA
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000

metaR UAG2EMAi
is: SBO:0000176
reactant: MODEL1310110003#
fast: false
reversible: false
name: UDP-N-acetyl-D-glucosamine 2-epimerase (Hydrolysis)
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/5.1.3.14
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.14 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835 NOTES:

metaM HC01104 e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
type: Species
name: 4-nitrophenyl phosphate(2-)
has only substance units: false
is: CHEBI:61146

metaR S23T3g
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
is version of: http://identifiers.org/ec-code/2.4.99.6
is: SBO:0000176
kinetic law: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
type: Reaction
product: MODEL1310110003#
is described by: ECO:0000000
modifier: MODEL1310110003#
reversible: false
reactant: MODEL1310110003#

metaR GCHOLAte
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
reversible: true
name: bile acid intracellular transport

metaM lnlnca c
has only substance units: false
name: alpha-linolenate
initial amount: NaN
is: SBO:0000247
is: CHEBI:32387
is: HMDB01388
initial concentration: 1.0
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
boundary condition: false
type: Species
constant: false

metaM utp n
has only substance units: false
name: UTP(4-)
is: SBO:0000247
is: CHEBI:46398
type: Species
constant: false
boundary condition: false
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
initial concentration: 1.0
is: HMDB00285
initial amount: NaN

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR r1651
modifier: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_86078c8f_b63a_4d4d_b99b_692d729d9f8c
constant: false
type: Species
is encoded by: hsa:641371
initial concentration: NaN
name: ACOT1
boundary condition: true
initial amount: NaN
is: E9KL42
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_ca35e62a_ade7_48dd_8df3_94c8c7b67f1a
constant: false
is: SBO:0000252
boundary condition: true
name: _AA614647_1_c
is encoded by: hsa:AA614647
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_d58e6704_4e98_46b8_80cf_1ecff5a27258
initial amount: NaN
initial concentration: NaN
is: Q49AT3
type: Species
is encoded by: hsa:8706
name: B3GALNT1
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaM thym e
is: CHEBI:17821
constant: false
is: HMDB00262
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
has only substance units: false
is: SBO:0000247
name: thymine
initial amount: NaN
type: Species

metaR CYTK7
is: SBO:0000176
is described by: ECO:0000269
name: cytidylate kinase (CMP,UTP)
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110003#
fast: false
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true

metaR TSTSTERONEt
product: MODEL1310110003#
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
is described by: ECO:0000269
is: SBO:0000185
name: Testosterone transport

metaR AHEXASE2ly
kinetic law: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#
name: beta-N-acetylhexosaminidase, lysosomal
reversible: false
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction

metaM 10fthf e
has only substance units: false
constant: false
initial amount: NaN
is: HMDB00972
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
type: Species
initial concentration: 1.0
is: CHEBI:57454
name: 10-formyltetrahydrofolate(2-)
is: SBO:0000247

metaR r1593
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_dbda75e4_f930_463f_9a64_2c72bf3bc0eb
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:224
name: ALDH3A2
is: SBO:0000252
initial concentration: NaN
type: Species
is: P51648

metaM Rtotal e
constant: false
is: SBO:0000247
is: CHEBI:3554
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: HMDB00244
initial concentration: 1.0
name: R total
is: C00255
notes: FORMULA: CO2FULLR CHARGE: -1

metaR CYTK3
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000269
product: MODEL1310110003#
is: SBO:0000176
modifier: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
name: cytidylate kinase (CMP)(GTP)
fast: false

metaM udpacgal l
initial amount: NaN
is: HMDB00304
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: CHEBI:57847

metaR ADNt
modifier: MODEL1310110003#
fast: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
name: adenosine facilated transport in cytosol
reactant: MODEL1310110003#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269
is: SBO:0000185

metaM doldp U r
is: CHEBI:15750
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: Dolichol diphosphate, human uterine homolog
type: Species
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_37dd80f3_6f1f_4bbf_947b_52ec6b438fe6
initial concentration: NaN
type: Species
is: O95497
constant: false
is encoded by: hsa:8876
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: VNN1

http://identifiers.org/biomodels.db/MODEL1310110003#_feddac5d_1ad4_491f_8914_eff3cc45fb7e
initial amount: NaN
has only substance units: false
boundary condition: true
name: TPI1P2
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:286016
type: Species

metaM cit e
has only substance units: false
name: citrate(3-)
boundary condition: false
type: Species
is: CHEBI:16947
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0
constant: false
is: HMDB00094
initial amount: NaN
is: SBO:0000247

metaR r1590
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110003#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_75f19eaf_c007_4c7e_9dc5_dccbb62d3ae9
is encoded by: hsa:1346
type: Species
name: COX7A1
is: P24310
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR r1654
is described by: ECO:0000000
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_6ca03c5a_074c_4764_94fe_9b850418f3d4
initial amount: NaN
name: ALDH9A1
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: P49189
boundary condition: true
is encoded by: hsa:223
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_5c4e9b6f_7089_4077_9711_30687f323dbe
is encoded by: hsa:570
initial amount: NaN
is: SBO:0000252
is: Q14032
boundary condition: true
name: BAAT
constant: false
initial concentration: NaN
type: Species
has only substance units: false

metaR EX retfa LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: fatty acid retinol exchange
type: Reaction

metaM rib D e
boundary condition: false
initial concentration: 1.0
is: HMDB00283
is: SBO:0000247
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
constant: false
has only substance units: false
is: CHEBI:16988
initial amount: NaN
type: Species
name: D-ribose

metaR CYTK4
is: SBO:0000176
modifier: MODEL1310110003#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000269
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
reversible: true
name: cytidylate kinase (dCMP)(GTP)

metaM for e
type: Species
is: CHEBI:15740
initial concentration: 1.0
boundary condition: false
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
constant: false
has only substance units: false
name: formate
is: SBO:0000247
is: HMDB00142
initial amount: NaN

metaM lnlnca e
initial amount: NaN
is: SBO:0000247
is: HMDB01388
is: CHEBI:32387
has only substance units: false
name: alpha-linolenate
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
constant: false

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

metaM ksi pre11 g
name: keratan sulfate I biosynthesis, precursor 11
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:28067
is: SBO:0000247
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
has only substance units: false
initial amount: NaN
constant: false

metaR DCYTt
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true
is: SBO:0000185
name: deoxycytidine transport via diffusion
is described by: ECO:0000000

metaR ATP1ter
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110003#
name: ADP/ATP transporter, endoplasmic reticulum
reactant: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110003#
is described by: ECO:0000000

metaR NADtpu
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
type: Reaction
reversible: false
product: MODEL1310110003#
is: SBO:0000185
name: NAD transporter, peroxisome
fast: false
reactant: MODEL1310110003#
is described by: ECO:0000000

metaR r1591
product: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110003#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110003#

metaR r1653
reactant: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
is described by: ECO:0000000

metaR CYTK5
modifier: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
name: cytidylate kinase (dCMP)
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110003#
fast: false
reversible: true

metaR B3GNT39g
modifier: MODEL1310110003#
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110003#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
reactant: MODEL1310110003#
product: MODEL1310110003#

metaR PI4PLC
reversible: false
is described by: ECO:0000269
product: MODEL1310110003#
fast: false
type: Reaction
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.4.11
kinetic law: MODEL1310110003#
name: phosphatidylinositol 4-phosphate phospholipase C
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
reactant: MODEL1310110003#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_c23e5424_0ab2_495d_9f4a_9bc45e438952
is: P00915
name: CA1
is encoded by: hsa:759
has only substance units: false
boundary condition: true
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM 10fthf c
type: Species
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
has only substance units: false
initial amount: NaN
name: 10-Formyltetrahydrofolate
is: CHEBI:57454
is: HMDB00972
initial concentration: 1.0
is: SBO:0000247
is: C00234
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_0a814697_6e14_4f30_b1dd_6bb08ca54c25
is: B3KUK6
boundary condition: true
name: NT5C1B
is encoded by: hsa:93034
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
constant: false

metaR FUMSO4tm
reactant: MODEL1310110003#
is described by: ECO:0000269
type: Reaction
reversible: true
modifier: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Fumarate:sulfate antiport, mitochondrial
fast: false
is: SBO:0000185
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_0eca27ac_30fc_4528_b9fa_be142ec690be
initial concentration: NaN
type: Species
is encoded by: hsa:AI191472
has only substance units: false
initial amount: NaN
boundary condition: true
name: _AI191472_1_c
is: SBO:0000252
constant: false

metaM glyc e
constant: false
initial concentration: 1.0
name: Glycerol
is: CHEBI:17754
boundary condition: false
is: HMDB00131
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00116
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_deef2207_c916_4940_8a58_d77ab79e5913
name: ADSSL1
is: B3KTV4
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:122622
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR DGAT
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
modifier: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (8694.1) or (84649.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11481335 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
reversible: false
type: Reaction
name: diacylglycerol acyltransferase
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.20

metaR r1656
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_c3ebe710_bfd3_494b_a8ec_b9b876fe423b
type: Species
name: SLC16A8
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:23539
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: O95907

metaM itp n
boundary condition: false
type: Species
is: HMDB00189
has only substance units: false
name: ITP(3-)
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
is: CHEBI:57614

metaM fadh2 c
name: FADH2(2-)
constant: false
type: Species
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H35N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,32,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H2,33,34,42,43)/p-2/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58307
has only substance units: false
is: HMDB01197

metaM cholate c
is: CHEBI:29747
has only substance units: false
is: SBO:0000247
name: Cholate
type: Species
initial amount: NaN
is: HMDB00619
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
initial concentration: 1.0
constant: false
boundary condition: false

metaR CITtbm
is: SBO:0000185
modifier: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
product: MODEL1310110003#
is described by: ECO:0000269
kinetic law: MODEL1310110003#
fast: false
name: citrate transport, mitochondrial
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF

metaM Rtotal c
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01448
is: CHEBI:16189
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: CO2FULLR CHARGE: -1
name: R total

metaM l2fn2m2masn g
notes: FORMULA: C68H113N4O49X CHARGE: 0
is: CHEBI:28067
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
has only substance units: false
constant: false

metaM xol27oh m
is: SBO:0000247
has only substance units: false
is: CHEBI:17703
initial amount: NaN
constant: false
is: HMDB02103
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
initial concentration: 1.0
type: Species
boundary condition: false
name: 26-hydroxycholesterol

metaM thyox L c
constant: false
type: Species
is: CHEBI:18332
initial concentration: 1.0
name: L-thyroxine
initial amount: NaN
is: HMDB00248
has only substance units: false
boundary condition: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
is: SBO:0000247

metaR r2019
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_dd87ceba_b71d_4722_bb96_8fe7d4946568
initial concentration: NaN
is encoded by: hsa:4126
is: O00462
type: Species
initial amount: NaN
boundary condition: true
name: MANBA
has only substance units: false
is: SBO:0000252
constant: false

metaR PPAm
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
reactant: MODEL1310110003#
name: inorganic diphosphatase
is version of: http://identifiers.org/ec-code/3.6.1.1
reversible: false
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
is: SBO:0000176
product: MODEL1310110003#

metaM cit c
constant: false
name: Citrate
initial amount: NaN
is: C00158
boundary condition: false
is: HMDB00094
initial concentration: 1.0
is: CHEBI:16947
is: SBO:0000247
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_bea4c090_ec23_43b0_a632_6b6f691f421f
is encoded by: hsa:35
name: ACADS
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
is: P16219
is: SBO:0000252
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_66fa4ae1_45ac_433c_9f83_cab81eece515
is encoded by: hsa:2629
has only substance units: false
is: B7Z6S1
initial concentration: NaN
boundary condition: true
constant: false
name: GBA
initial amount: NaN
type: Species
is: SBO:0000252

metaM hs deg6 l
constant: false
name: heparan sulfate, degradation product 6
is: SBO:0000247
is: HMDB00719
initial amount: NaN
notes: FORMULA: C67H98N4O83S9 CHARGE: -10
is: CHEBI:15699
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_f625efc6_1b17_4937_b74f_59504238a96d
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3038
type: Species
is: O00219
name: HAS3

http://identifiers.org/biomodels.db/MODEL1310110003#_0f850a1c_65b6_41e6_ad2d_b4cdf6a221cc
has only substance units: false
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:1606
name: DGKA
is: P23743

http://identifiers.org/biomodels.db/MODEL1310110003#_a66dcac4_60a3_472c_883f_53128411606d
constant: false
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: SLC25A1
is: D9HTE9
initial amount: NaN
is encoded by: hsa:6576
initial concentration: NaN

metaR 2HBt2
reactant: MODEL1310110003#
modifier: MODEL1310110003#
name: 2-hydroxybutyrate cotransport with proton
is described by: ECO:0000269
fast: false
reversible: true
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_4998c555_6629_48e8_88f8_382859f78380
is encoded by: hsa:9197
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
is: O00400
has only substance units: false
name: SLC33A1

http://identifiers.org/biomodels.db/MODEL1310110003#_0cf4846e_7262_4611_9323_273035537b36
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: Q9Y2D0
constant: false
has only substance units: false
name: CA5B
initial concentration: NaN
is encoded by: hsa:11238

metaM for c
initial concentration: 1.0
is: HMDB00142
initial amount: NaN
boundary condition: false
is: C00058
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
type: Species
has only substance units: false
is: CHEBI:15740
name: Formate
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_6300d444_35fe_479d_87e9_f63c7c5bfcbc
name: AMY1B
initial amount: NaN
has only substance units: false
is: P04745
is encoded by: hsa:277
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true

metaM leugly c
boundary condition: false
notes: FORMULA: C8H16N2O3 CHARGE: 0
is: http://identifiers.org/pubchem.compound/97364
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: Leucylglycine
constant: false
is: SBO:0000247

metaM dhea c
initial concentration: 1.0
constant: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
initial amount: NaN
name: 3beta-hydroxyandrost-5-en-17-one
is: HMDB00077
has only substance units: false
type: Species
is: CHEBI:28689
boundary condition: false
is: SBO:0000247

metaR S3TASE2ly
product: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
reversible: true
reactant: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: N-acetylglucosamine-3-sulfatase, lysosomal
kinetic law: MODEL1310110003#

metaM thcrm hs g
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:24636
constant: false
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
initial amount: NaN
boundary condition: false
type: Species
name: trihexosyl ceramide

metaR r1655
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110003#
is: SBO:0000185
modifier: MODEL1310110003#
fast: false

metaM strdnccoa c
is: http://identifiers.org/pubchem.compound/47205473
type: Species
has only substance units: false
is: HMDB06519
constant: false
initial amount: NaN
is: C16163
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
name: stearidonyl coenzyme A

metaM ahdt e
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
is: CHEBI:58462
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895
initial concentration: 1.0
has only substance units: false
is: HMDB00980
type: Species
constant: false

metaM pram c
is: SBO:0000247
initial amount: NaN
is: HMDB01128
has only substance units: false
type: Species
is: CHEBI:58681
boundary condition: false
name: 5-Phospho-beta-D-ribosylamine
constant: false
is: C03090
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
initial concentration: 1.0

metaM glyc c
type: Species
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
initial concentration: 1.0
name: Glycerol
constant: false
is: C00116
is: HMDB00131
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:17754
boundary condition: false

metaR r0822
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
fast: false
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR THYOXt2
product: MODEL1310110003#
is described by: ECO:0000269
name: T4 transport via facilitated diffusion
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110003#
is: SBO:0000185

metaM cmpacna n
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:57812
has only substance units: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
name: CMP-N-acetyl-beta-neuraminate(2-)
is: HMDB01176
boundary condition: false
initial concentration: 1.0

metaM cholate e
initial amount: NaN
is: HMDB00619
constant: false
is: SBO:0000247
is: CHEBI:29747
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
name: Cholate
initial concentration: 1.0

metaR r1658
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
is described by: ECO:0000000

metaR 3MOBte
name: Transport of 3-methyl-2-oxobutanoate
kinetic law: MODEL1310110003#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
fast: false

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR DNDPt33m
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
reversible: false
is described by: ECO:0000269
type: Reaction
name: dGDP transport via dUDP antiport
is: SBO:0000185
kinetic law: MODEL1310110003#
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_32f91114_61a1_4cdc_8c0e_17455d4b0467
boundary condition: true
name: _AL525798_1_c
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:AL525798
constant: false
has only substance units: false
is: SBO:0000252

metaR EX ribflv LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Riboflavin
type: Reaction

metaM dpcoa e
is: HMDB01373
initial amount: NaN
is: C00882
is: SBO:0000247
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
name: Dephospho-CoA
is: CHEBI:57328

metaR r2141
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
modifier: MODEL1310110003#
fast: false

metaM h r
is: http://identifiers.org/pubchem.compound/3380
name: proton
initial concentration: 1.0
boundary condition: false
is: C00080
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:24636
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080

metaR CYTK8
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
product: MODEL1310110003#
is described by: ECO:0000269
name: cytidylate kinase (CMP,dATP)
type: Reaction
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
modifier: MODEL1310110003#
is: SBO:0000176
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_d0785679_e114_4b64_9954_9f85d6809c39
is encoded by: hsa:23517
constant: false
name: SKIV2L2
type: Species
has only substance units: false
is: Q3MHC9
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM Rtotalcoa c
has only substance units: false
is: HMDB01448
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
name: R total Coenzyme A
initial concentration: 1.0
is: CHEBI:16189
boundary condition: false
initial amount: NaN
type: Species
constant: false
is: SBO:0000247

metaR MG3er
reactant: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
is described by: ECO:0000000
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
reversible: false
type: Reaction
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD

http://identifiers.org/biomodels.db/MODEL1310110003#_e6312164_1005_49cf_a6c9_a885d28c3a1e
boundary condition: true
is encoded by: hsa:7264
constant: false
initial concentration: NaN
initial amount: NaN
is: Q13630
name: TSTA3
has only substance units: false
is: SBO:0000252
type: Species

metaM thyox L e
is: SBO:0000247
initial amount: NaN
is: HMDB00248
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:18332
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
name: L-thyroxine

metaR r0821
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
reactant: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:17173541,PMID:18406340,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.85
is: SBO:0000185

metaR r1657
reactant: MODEL1310110003#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110003#
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
is described by: ECO:0000000
type: Reaction

metaM leugly e
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/97364
notes: FORMULA: C8H16N2O3 CHARGE: 0
boundary condition: false
name: Leucylglycine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_0238a7ad_8807_44f1_a8d4_1bcd0421ee75
is encoded by: hsa:158
initial amount: NaN
has only substance units: false
name: ADSL
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
type: Species

metaR HSD3B12r
product: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.145
reversible: false
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
notes: GENE_ASSOCIATION: (3284.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12832414 NOTES:kinetic studies done with recombinant human cDNA transfected into baculovirus
is: SBO:0000176
reactant: MODEL1310110003#
is described by: ECO:0000134

metaR HISt4
is: SBO:0000185
notes: GENE_ASSOCIATION: (11254.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10930503 NOTES:SAB
type: Reaction
name: L-histidine transport in via sodium symport
modifier: MODEL1310110003#
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: false
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_cda50abc_9ab0_4515_8df3_41d66be5772b
is encoded by: hsa:92745
name: SLC38A5
boundary condition: true
is: SBO:0000252
is: Q8WUX1
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaR r2018
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110003#
is described by: ECO:0000000
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
is: SBO:0000185
reversible: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR r2140
reactant: MODEL1310110003#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM 4mzym int1 r
is: HMDB06927
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
constant: false
name: 4-Methylzymosterol intermediate 1
initial concentration: 1.0
has only substance units: false

metaR S6TASE1ly
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
type: Reaction
reversible: true
kinetic law: MODEL1310110003#

metaR CYTK9
is: SBO:0000176
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
reactant: MODEL1310110003#
name: cytidylate kinase (CMP,dCTP)
modifier: MODEL1310110003#
product: MODEL1310110003#

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaM thym c
is: C00178
has only substance units: false
initial amount: NaN
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
initial concentration: 1.0
is: SBO:0000247
name: Thymine
is: HMDB00262
type: Species
boundary condition: false
constant: false
is: CHEBI:17821

http://identifiers.org/biomodels.db/MODEL1310110003#_2dd92d5c_7386_43d9_8003_fb2202dc6569
has only substance units: false
boundary condition: true
initial concentration: NaN
name: CHAT
is: Q6LEN6
is encoded by: hsa:1103
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

metaR RTOTAL3t
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
name: RTOTAL3 transport
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110003#

metaR CYSTSERex
notes: GENE_ASSOCIATION: (6519.1 and 11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:SAB see PMID 14770310
fast: false
product: MODEL1310110003#
is described by: ECO:0000269
type: Reaction
name: L-cystine/glycine exchanger (cystine in)
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#

metaR BALAtmr
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reversible: true
fast: false
name: Beta-alanine reversible mitochondrial transport (diffusion)
type: Reaction
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
is: SBO:0000185

metaM leuktrD4 e
is: CHEBI:28666
is: SBO:0000247
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
name: Leukotriene D4
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: HMDB03080
type: Species
boundary condition: false

metaR HSD3B3r
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.145
name: 3 beta-hydroxysteroid dehydrogenase type 1
type: Reaction
product: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3284.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11384872,PMID:14643063 NOTES:see PMID: 14643063 specific cofactors/etc have not yet been determined - largely inferred NJ
fast: false
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000269
reactant: MODEL1310110003#

metaM HC00319 c
initial amount: NaN
type: Species
is: CHEBI:30794
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
name: Malonate
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_4636bb1e_b18d_4f74_a944_14a9f7577441
has only substance units: false
is encoded by: hsa:8501
constant: false
is: SBO:0000252
initial amount: NaN
name: SLC43A1
is: O75387
boundary condition: true
initial concentration: NaN
type: Species

metaR RDH1a
name: retinol dehydrogenase (all-trans,NADPH)
is: SBO:0000176
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.1.300
reactant: MODEL1310110003#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.1.105
type: Reaction
kinetic law: MODEL1310110003#
fast: false
reversible: true

metaR r1643
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0780
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110003#
reversible: true
is: SBO:0000176
product: MODEL1310110003#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16

metaM 3hpp m
initial amount: NaN
constant: false
is: CHEBI:16510
is: HMDB00700
name: 3-hydroxypropionate
type: Species
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM xol7ah c
boundary condition: false
type: Species
constant: false
name: 7alpha-hydroxy-5beta-cholestan-3-one
initial concentration: 1.0
initial amount: NaN
is: HMDB06892
has only substance units: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
is: SBO:0000247
is: CHEBI:2290

metaR THFtm
type: Reaction
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
kinetic law: MODEL1310110003#
is: SBO:0000185
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110003#

metaM leuktrE4 c
constant: false
is: HMDB02200
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: CHEBI:57462
initial concentration: 1.0
type: Species
initial amount: NaN
name: leukotriene E4(1-)
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM stcoa c
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: CHEBI:57394
has only substance units: false
name: Stearoyl-CoA (n-C18:0CoA)
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: C00412
is: HMDB01114
is: SBO:0000247

metaR r1377
kinetic law: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
reactant: MODEL1310110003#
fast: false
product: MODEL1310110003#
is: SBO:0000176
type: Reaction
reversible: true
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22

metaR RE3241R
product: MODEL1310110003#
reversible: false
name: RE3241
type: Reaction
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:

metaR r0480
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reactant: MODEL1310110003#

metaM man e
initial concentration: 1.0
is: HMDB00169
name: D-Mannose
type: Species
is: SBO:0000247
is: C00159
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
constant: false
is: CHEBI:16024
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_0ccfce07_aa99_451a_96fe_7030bcb77dc9
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
name: AK2
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:204
is: P54819

metaM ocdca e
is: CHEBI:25629
is: SBO:0000247
constant: false
is: HMDB00827
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
name: octadecanoate (n-C18:0)
initial concentration: 1.0
is: C01530
boundary condition: false

metaM pmtcrn c
constant: false
boundary condition: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: CHEBI:17490
is: HMDB00222
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
name: L-palmitoylcarnitine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_021df50f_da02_4a8f_b26a_f58f2c8e69c2
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is: O15269
is encoded by: hsa:10558
name: SPTLC1
initial amount: NaN
has only substance units: false

metaM 4ppcys c
constant: false
boundary condition: false
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
is: C04352
type: Species
has only substance units: false
is: CHEBI:59458
initial amount: NaN
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial concentration: 1.0
is: HMDB01117
is: SBO:0000247

metaR HS3ly
modifier: MODEL1310110003#
reversible: false
name: heparan-N-sulfatase, lysosomal
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.10.1.1
fast: false
product: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_0f431ab7_243a_4d80_b664_bffe5cf88d62
has only substance units: false
is: O75715
initial concentration: NaN
is encoded by: hsa:2880
name: GPX5
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_bc3db88f_cae5_455e_9784_f19d0359db86
constant: false
is: Q9Y6L6
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
name: SLCO1B1
is encoded by: hsa:10599

metaR RE1804M
name: RE1804
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110003#
is: SBO:0000176
reactant: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
modifier: MODEL1310110003#
product: MODEL1310110003#
reversible: true
type: Reaction
fast: false

metaR AG13T12g
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is described by: ECO:0000000

metaM gthox c
type: Species
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
initial concentration: 1.0
name: Oxidized glutathione
is: C00127
is: HMDB03337
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:58297
initial amount: NaN
is: SBO:0000247

metaR r1644
type: Reaction
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: true
is: SBO:0000185
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_47bacadd_cd7d_4ace_b24f_9c25d9c2fab6
boundary condition: true
has only substance units: false
name: MTMR2
type: Species
is encoded by: hsa:8898
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: A6NN98

metaR r0781
fast: false
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.17
is version of: http://identifiers.org/ec-code/4.2.1.107
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110003#
is: SBO:0000176
modifier: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
type: Reaction

metaM 5adtststerone e
constant: false
is: SBO:0000247
is: CHEBI:16330
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 17beta-hydroxy-5alpha-androstan-3-one
type: Species
is: HMDB02961
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
initial amount: NaN

metaM CE5788 e
name: kinetensin 1-7
initial amount: NaN
is: CHEBI:27485
has only substance units: false
boundary condition: false
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB02710
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_901e87f9_6819_4554_901c_c628b23ae621
initial concentration: NaN
has only substance units: false
is: P30084
name: ECHS1
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:1892
type: Species
boundary condition: true

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaR SO4CLtex2
kinetic law: MODEL1310110003#
is: SBO:0000185
product: MODEL1310110003#
type: Reaction
fast: false
name: sulfate transport via chloride countertransport (2:1)
is described by: ECO:0000304
reversible: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110003#
modifier: MODEL1310110003#

metaM gua e
type: Species
initial amount: NaN
is: CHEBI:16235
has only substance units: false
name: guanine
boundary condition: false
is: HMDB00132
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242

http://identifiers.org/biomodels.db/MODEL1310110003#_ef0568f8_f285_4308_9fc6_d81a02addb4f
constant: false
is: SBO:0000252
is encoded by: hsa:57786
name: RBAK
type: Species
is: Q9NYW8
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM dump n
constant: false
name: dUMP(2-)
is: CHEBI:246422
initial amount: NaN
initial concentration: 1.0
is: HMDB01409
type: Species
boundary condition: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: SBO:0000247
has only substance units: false

metaM maltttr e
is: C02052
boundary condition: false
constant: false
has only substance units: false
name: Maltotetraose
is: SBO:0000247
is: HMDB01296
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
initial amount: NaN
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5141

http://identifiers.org/biomodels.db/MODEL1310110003#_06512426_f9c6_4607_b563_3adcf1027bd0
name: HKDC1
is encoded by: hsa:80201
has only substance units: false
initial concentration: NaN
type: Species
is: B3KT70
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_91c87537_51cb_42aa_8020_55f6185b247b
name: GGT5
constant: false
is: SBO:0000252
is encoded by: hsa:2687
boundary condition: true
initial amount: NaN
is: P36269
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_769e71f0_6204_4440_b43a_a37e42a12701
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:10449
name: ACAA2
boundary condition: true
constant: false
initial concentration: NaN
is: P42765
is: SBO:0000252

metaR PUNP1
is described by: ECO:0000269
product: MODEL1310110003#
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Adenosine)

metaR CHOLtn
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000
name: Choline transport, nuclear through pores
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
kinetic law: MODEL1310110003#

metaR FATP2t
product: MODEL1310110003#
name: fatty acid electroneutral transport
reversible: true
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110003#

metaR S3TASE1ly
kinetic law: MODEL1310110003#
name: N-acetylglucosamine-3-sulfatase, lysosomal
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_1305194d_dceb_4512_ac87_f5c3e665fdb5
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:123041
name: SLC24A4
type: Species
boundary condition: true

metaR r0782
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: PMID:10410995,PMID:2428310,PMID:9603974 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110003#
reversible: false
type: Reaction
product: MODEL1310110003#
name: GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing) Fructose and mannose metabolism EC:1.1.1.271
reactant: MODEL1310110003#

metaR r0591
modifier: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
fast: false
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaM man g
constant: false
initial concentration: 1.0
is: CHEBI:16024
name: D-mannose
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: SBO:0000247
is: HMDB00169

http://identifiers.org/biomodels.db/MODEL1310110003#_3ce334ea_06c7_4db1_aa90_967fb902f880
initial concentration: NaN
name: GALNT2
is: Q10471
is: SBO:0000252
type: Species
is encoded by: hsa:2590
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_beb318a9_49cc_4bac_bc55_7e95e99fa7fb
is encoded by: hsa:222
type: Species
is: P48448
constant: false
name: ALDH3B2
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_71b7683f_d07b_43eb_9ef3_e38b7fe4a106
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: AICDA
type: Species
is: Q546Y9
is encoded by: hsa:57379
initial concentration: NaN

metaR THYMt
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
is: SBO:0000185
name: thymine reversible transport via facilated diffusion
fast: false
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
is described by: ECO:0000269

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM ocdca c
is: CHEBI:25629
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
constant: false
is: HMDB00827
initial amount: NaN
name: stearate
initial concentration: 1.0
boundary condition: false

metaR r0707
reversible: true
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.168
product: MODEL1310110003#
type: Reaction
fast: false
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_6324f2b0_5b44_4a44_a002_91409668104b
is: O14556
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:26330
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
name: GAPDHS

metaR NCNt
reactant: MODEL1310110003#
is described by: ECO:0000269
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110003#
name: Na+/Ca2+-NH4+ exchange
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
fast: false

metaR r1645
is: SBO:0000185
reversible: true
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110003#
is described by: ECO:0000000
fast: false
product: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR TYRDOPO
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (7299.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.18.1 Confidence Level: 4 AUTHORS: PMID:5294951 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110003#
reversible: false
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.14.18.1
name: Tyrosine:dopa oxidase
modifier: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000176

metaM ha e
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
is: CHEBI:16336
constant: false
name: hyaluronan

http://identifiers.org/biomodels.db/MODEL1310110003#_c23afe41_78c1_416a_9d0d_6d58ffc01533
type: Species
boundary condition: true
is: Q9H845
is encoded by: hsa:28976
initial concentration: NaN
name: ACAD9
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_d4064132_c96f_4720_909d_cdbe585b0903
name: _AA526438_1_c
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:AA526438
constant: false
initial concentration: NaN
initial amount: NaN

metaR r0512
type: Reaction
product: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.4.1
fast: false
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
reversible: true

metaR RE3218C
is: SBO:0000176
name: RE3218
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.6.2
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#
reversible: true
product: MODEL1310110003#
type: Reaction

metaM dhcholestanate x
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: SBO:0000247
is: CHEBI:16577
constant: false
has only substance units: false
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
is: HMDB00359

http://identifiers.org/biomodels.db/MODEL1310110003#_ac238621_e8da_42dd_92bd_c762fd150e04
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
name: PPAP2A
is encoded by: hsa:8611
is: G3XA95
constant: false
initial concentration: NaN

metaR r0400
name: N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.2.4.4
notes: GENE_ASSOCIATION: (594.1) or (641649.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11522391,PMID:12192086 NOTES:
fast: false

metaM 5adtststerone c
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB02961
is: CHEBI:16330
name: 17beta-hydroxy-5alpha-androstan-3-one

metaR r0783
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
reversible: true
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
is: SBO:0000176
reactant: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM thbpt4acam n
name: 4a-hydroxytetrahydrobiopterin
is: HMDB02281
is: CHEBI:15374
is: SBO:0000247
type: Species
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN

metaM succ m
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: Succinate
has only substance units: false
constant: false
is: CHEBI:30031
is: HMDB00254
type: Species
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
boundary condition: false
is: C00042

metaM dhcrm hs c
has only substance units: false
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
is: CHEBI:31488
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
name: dihydroceramide
type: Species

metaR r0590
fast: false
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110003#
reversible: false
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110003#
is: SBO:0000176

metaR r1378
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
product: MODEL1310110003#
fast: false
is described by: ECO:0000000
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284

metaM HC01410 m
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: (2E)-Hexenoyl-CoA
is: CHEBI:28706
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_04942c94_6965_4964_9e4e_8b3b4b28bed3
type: Species
constant: false
is encoded by: hsa:29085
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: PHPT1
is: Q9P019
has only substance units: false
boundary condition: true

metaR RE2625C
is: SBO:0000176
kinetic law: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
fast: false
product: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is described by: ECO:0000000
name: RE2625

metaR r0706
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
fast: false
type: Reaction
modifier: MODEL1310110003#
is: SBO:0000176
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.3.99.10

metaR r1646
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110003#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110003#
reversible: true
fast: false
modifier: MODEL1310110003#

metaR CYSGLTH
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110003#
fast: false
name: Glutathione:cystine oxidoreductase

metaR r0638
is version of: http://identifiers.org/ec-code/2.8.1.2
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110003#
name: trans-Dodec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction

metaM ppa c
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
has only substance units: false
name: propionate
is: CHEBI:17272
type: Species
is: HMDB00237
initial amount: NaN

metaM ppi c
constant: false
is: SBO:0000247
is: HMDB00250
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: HO7P2 CHARGE: -3
is: C00013
name: Diphosphate
boundary condition: false
is: CHEBI:0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_9990f400_7c67_47f8_9dae_66371c6fb796
is: O95528
boundary condition: true
constant: false
name: SLC2A10
is encoded by: hsa:81031
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR CITL
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: false
name: Citrate lyase
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
product: MODEL1310110003#
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_7beb293b_c861_4454_b58f_ce4cba3d94bb
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR SPH1Pte
product: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
reactant: MODEL1310110003#
name: sph1p transport

metaR RE0944E
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.1
reactant: MODEL1310110003#
reversible: true
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false
name: RE0944
kinetic law: MODEL1310110003#
is: SBO:0000176

metaR r0784
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15

http://identifiers.org/biomodels.db/MODEL1310110003#_aff0da46_5c36_457a_b472_88c1de3a4316
has only substance units: false
constant: false
is encoded by: hsa:5052
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
name: PRDX1
boundary condition: true

metaR UROLACer
product: MODEL1310110003#
name: uronolactonase, endoplasmic reticulum
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110003#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110003#

metaR GDPFUCtg
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
type: Reaction
name: GDPFuc Golgi transport via CMP antiport
modifier: MODEL1310110003#
reversible: true

metaR FADH2tru
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
name: FADH2 transporter, endoplasmic reticulum
reactant: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110003#
fast: false
product: MODEL1310110003#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110003#_65c2736f_24a2_436c_ac8a_24cc35f6d3d4
initial amount: NaN
is encoded by: hsa:1798
boundary condition: true
is: SBO:0000252
constant: false
name: DPAGT1
initial concentration: NaN
type: Species
has only substance units: false

metaR MAN6PI
type: Reaction
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/5.3.1.8
name: mannose-6-phosphate isomerase
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_e2231609_cfba_4537_a6e6_85e8480db099
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: _AI935189_1_m
boundary condition: true
is encoded by: hsa:AI935189
is: SBO:0000252
type: Species

metaM bilglcur c
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
is: CHEBI:57767
initial amount: NaN
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)
initial concentration: 1.0

metaM arachcrn c
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
constant: false
type: Species
is: HMDB06460
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: arachidyl carnitine
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_5886f921_ba32_4b1d_b45e_267eb6a79524
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:NM 013421
name: _NM_013421_1_m
boundary condition: true

metaM 34dhmald c
is: SBO:0000247
boundary condition: false
is: C05577
type: Species
initial concentration: 1.0
is: HMDB06242
initial amount: NaN
name: 3,4-Dihydroxymandelaldehyde
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
has only substance units: false
is: http://identifiers.org/pubchem.compound/7903
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_265cf5ab_2911_4c3c_857c_530f45b3d965
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: FDFT1
is: P37268
type: Species
has only substance units: false
is encoded by: hsa:2222

metaR UGT1A10r
kinetic law: MODEL1310110003#
is described by: ECO:0000134
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
is version of: http://identifiers.org/ec-code/2.4.1.17
type: Reaction
reactant: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
is: SBO:0000176
reversible: true
product: MODEL1310110003#

metaM orn e
boundary condition: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: C01602
is: CHEBI:0
type: Species
is: SBO:0000247
is: HMDB00214
constant: false
name: Ornithine
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR CAt7r
reactant: MODEL1310110003#
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000269
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6547.6) or (6547.4) or (6547.2) or (6546.1) or (6547.1) or (6547.5) or (6543.1) or (6547.3) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12406570,PMID:2484986 NOTES:MM
name: calcium / sodium antiporter (1:3), reversible
is: SBO:0000185
product: MODEL1310110003#
fast: false

metaR r0596
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
modifier: MODEL1310110003#
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false

metaR r1640
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
is: SBO:0000185

metaM gdpfuc g
boundary condition: false
constant: false
is: CHEBI:57984
is: SBO:0000247
is: HMDB01095
initial amount: NaN
has only substance units: false
name: GDP-L-fucose(2-)
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
initial concentration: 1.0
type: Species

metaR CERT2rt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
reactant: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.7.11.1
name: ceramide transport protein

metaM idour c
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:21338
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
type: Species
name: L-iduronate
is: HMDB02704
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_d12d52ce_d5e2_41d1_a6aa_4738b4f07e7f
is: SBO:0000252
has only substance units: false
is encoded by: hsa:160851
initial amount: NaN
constant: false
boundary condition: true
name: DGKH
is: Q86XP1
initial concentration: NaN
type: Species

metaR PUNP5
is version of: http://identifiers.org/ec-code/2.4.2.1
product: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Inosine)
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase

http://identifiers.org/biomodels.db/MODEL1310110003#_90466e75_0eab_4bc6_8b8f_0234022a578b
initial concentration: NaN
initial amount: NaN
is: Q8TF08
is encoded by: hsa:170712
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
name: COX7B2
type: Species

metaR VALTAm
modifier: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.42
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
name: valine transaminase, mitochondiral
is: SBO:0000176
reversible: true
type: Reaction
is described by: ECO:0000269

metaR r1418
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
kinetic law: MODEL1310110003#
type: Reaction
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_81ca8de3_91d6_4f5d_a780_e73c096b6b06
is: SBO:0000252
type: Species
is: Q01959
constant: false
name: SLC6A3
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6531

metaR CHAT
modifier: MODEL1310110003#
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: Choline O-acetyltransferase
kinetic law: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
reactant: MODEL1310110003#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.6

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR CO2t
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110003#
reversible: true
name: CO2 transporter via diffusion
product: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
type: Reaction

metaM man c
is: HMDB00169
type: Species
is: SBO:0000247
is: C00159
has only substance units: false
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial concentration: 1.0
initial amount: NaN
constant: false
name: D-Mannose
is: CHEBI:16024

metaR F1Atg
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
fast: false
product: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
name: F1alpha transport (from golgi to lysosome)
is: SBO:0000185

metaM icit c
initial concentration: 1.0
initial amount: NaN
constant: false
name: Isocitrate
is: HMDB00193
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: SBO:0000247
is: C00311
is: CHEBI:16087

http://identifiers.org/biomodels.db/MODEL1310110003#_7422e291_8728_476e_8dcc_91932844cb34
is encoded by: hsa:83697
type: Species
constant: false
initial amount: NaN
is: E9PDK1
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: SLC4A9
boundary condition: true

metaM leuktrE4 e
is: CHEBI:57462
is: HMDB02200
initial amount: NaN
constant: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: leukotriene E4(1-)

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_19d72dde_f09e_4cd8_898a_bd74f1e230d2
is: SBO:0000252
initial concentration: NaN
name: ACAD8
is: Q6ZWP6
constant: false
is encoded by: hsa:27034
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false

metaM xol7aone m
is: HMDB01993
initial concentration: 1.0
is: CHEBI:17899
type: Species
name: 7alpha-hydroxycholest-4-en-3-one
has only substance units: false
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR TKT2
fast: false
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.2.1.1
type: Reaction
reactant: MODEL1310110003#
name: transketolase
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
is: SBO:0000176
modifier: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
reversible: true

metaR r1641
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110003#
fast: false
type: Reaction
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0860
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
product: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/4.1.2.27
is described by: ECO:0000000
name: Utilized transport
kinetic law: MODEL1310110003#

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

metaR PUNP4
kinetic law: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
name: purine-nucleoside phosphorylase (Deoxyguanosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is: SBO:0000176
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110003#

metaM glyb m
type: Species
initial amount: NaN
name: glycine betaine
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB00043
initial concentration: 1.0
is: CHEBI:17750
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719

metaM b2coa m
is: CHEBI:57332
initial concentration: 1.0
name: crotonoyl-CoA(4-)
constant: false
boundary condition: false
initial amount: NaN
is: HMDB02009
is: SBO:0000247
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
type: Species
has only substance units: false

metaR r0926
reactant: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110003#
reversible: false
type: Reaction
kinetic law: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:4358819 NOTES:
name: Postulated transport reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_fa63d9bb_aebb_4046_a7f9_c50315b95355
is: B7Z1R0
initial concentration: NaN
boundary condition: true
is encoded by: hsa:57282
constant: false
type: Species
is: SBO:0000252
name: SLC4A10
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_b2a69310_3859_439b_a7fc_c10ce74d2ee7
is encoded by: hsa:10400
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
name: PEMT
boundary condition: true
type: Species
has only substance units: false

metaR BILGLCURtr
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
type: Reaction
reversible: true
is: SBO:0000185
name: glucuronidated compound transport
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
fast: false

metaM trdox c
constant: false
has only substance units: false
type: Species
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
is: C00343
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: Oxidized thioredoxin
boundary condition: false
is: CHEBI:18191

metaM bilglcur e
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
initial amount: NaN
is: CHEBI:57767
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)

metaM orn c
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: C01602
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00214
constant: false
boundary condition: false
is: CHEBI:0
initial concentration: 1.0
initial amount: NaN
name: Ornithine

metaM crn r
boundary condition: false
initial amount: NaN
is: CHEBI:16347
is: HMDB00062
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
name: (R)-carnitine
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_dfd440b1_0eeb_40ba_a7b2_5d821f39a166
has only substance units: false
is encoded by: hsa:2990
is: SBO:0000252
boundary condition: true
name: GUSB
initial concentration: NaN
type: Species
initial amount: NaN
is: P08236
constant: false

metaR r0594
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
product: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
is described by: ECO:0000000
type: Reaction

metaR r1642
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110003#
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185

metaR r0517
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
reversible: true
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR PUNP3
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110003#
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110003#
name: purine-nucleoside phosphorylase (Guanosine)
modifier: MODEL1310110003#
product: MODEL1310110003#

metaR PROSTGH2t
type: Reaction
name: Prostaglandin H2 transport
product: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110003#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
kinetic law: MODEL1310110003#

metaR r0787
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
is described by: ECO:0000000
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.1.1
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:

metaR CYTK2n
is described by: ECO:0000269
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
name: cytidylate kinase (dCMP),nuclear
modifier: MODEL1310110003#

metaR r0634
reactant: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
name: Octanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
reversible: true
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.4.1
kinetic law: MODEL1310110003#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:

metaM ksi pre29 g
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
initial concentration: 1.0
is: CHEBI:28067
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 29
constant: false

metaR PROSTGE2t2
kinetic law: MODEL1310110003#
name: prostaglandin uniport
is: SBO:0000185
reversible: true
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
modifier: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
is described by: ECO:0000269
fast: false

metaR CHOLtu
fast: false
product: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
is: SBO:0000185
modifier: MODEL1310110003#
is described by: ECO:0000269
name: Choline uniport
reactant: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev

metaR DNDPt10m
modifier: MODEL1310110003#
is: SBO:0000185
reversible: false
product: MODEL1310110003#
name: dADP transport via dCDP antiport
type: Reaction
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
kinetic law: MODEL1310110003#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_a6e8284b_5d67_449b_b7c4_15fd41951198
initial concentration: NaN
name: LDHB
initial amount: NaN
constant: false
is encoded by: hsa:3945
is: P07195
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_521cd090_39b0_410b_993c_7c32bac5fadb
initial amount: NaN
is: SBO:0000252
type: Species
is: P00338
name: LDHA
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:3939

metaM malcoa c
initial amount: NaN
is: SBO:0000247
constant: false
is: C00083
name: Malonyl-CoA
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
boundary condition: false
type: Species
is: HMDB01175
has only substance units: false
initial concentration: 1.0
is: CHEBI:57384

metaR INSTt4 2
type: Reaction
product: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
reversible: true
name: inositol transport via sodium symport
notes: GENE_ASSOCIATION: (115584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12039040,PMID:12133831 NOTES:NCD
is described by: ECO:0000006
modifier: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#

metaR r2371
kinetic law: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
type: Reaction
reactant: MODEL1310110003#

metaR r0788
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
reactant: MODEL1310110003#
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
modifier: MODEL1310110003#

metaM s7p c
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
is: SBO:0000247
name: Sedoheptulose 7-phosphate
initial concentration: 1.0
is: C05382
has only substance units: false
is: HMDB01068
is: CHEBI:57483
boundary condition: false
constant: false
type: Species
initial amount: NaN

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_ae35a3ec_a002_4cb6_acd7_595c9ae63f03
has only substance units: false
is: Q01581
is encoded by: hsa:3157
initial amount: NaN
constant: false
type: Species
name: HMGCS1
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_76b36dbf_16c4_4b30_891f_ef7f74c9225a
is encoded by: hsa:1347
has part: Q53YB7
is encoded by: hsa:84701
constant: false
is encoded by: hsa:1346
has part: P15954
has part: P14854
has part: Q6YFQ2
is encoded by: hsa:125965
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
has part: P12074
has part: P00414
has part: Q53XN1
is: SBO:0000297
has only substance units: false
is encoded by: hsa:1349
has part: P20674
has part: P13073
has part: Q8TF08
is encoded by: hsa:1329
initial concentration: NaN
is encoded by: hsa:9377
is encoded by: hsa:1350
has part: Q7GXY8
has part: P24311
is encoded by: hsa:4513
has part: Q7Z4L0
type: Species
is encoded by: hsa:4512
is encoded by: hsa:1337
has part: P24310
is encoded by: hsa:341947
has part: Q6FGA0
is encoded by: hsa:170712
has part: Q7GXZ8
is encoded by: hsa:1351
is encoded by: hsa:1345
has part: H0UI06
has part: Q96KJ9
initial amount: NaN
has part: Q02221
is encoded by: hsa:1327
is encoded by: hsa:9167
has part: P09669
is encoded by: hsa:4514
is encoded by: hsa:1339
boundary condition: true
is encoded by: hsa:1340

metaM hdcea c
boundary condition: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB03229
is: CHEBI:32372
name: Hexadecenoate (n-C16:1)
type: Species
initial amount: NaN
initial concentration: 1.0

metaR r0488
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
reactant: MODEL1310110003#
product: MODEL1310110003#
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
reversible: true
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#

metaR PPNCL3
reversible: false
is described by: ECO:0000269
product: MODEL1310110003#
type: Reaction
fast: false
name: phosphopantothenate-cysteine ligase
is: SBO:0000176
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/6.3.2.5
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_dfde6e14_7ab7_4061_874e_6b8ff8c9efe8
type: Species
name: SLC17A3
boundary condition: true
is: O00476
constant: false
is: SBO:0000252
is encoded by: hsa:10786
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_a0bd64a6_5bf2_4a4a_874b_956c44d5f226
has only substance units: false
is encoded by: hsa:3098
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: A8K7J7
type: Species
is: SBO:0000252
name: HK1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_fa317bac_227e_4ff3_aaa9_e08cfb8ee53a
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
name: CMAS
is encoded by: hsa:55907
is: Q8NFW8
initial amount: NaN
has only substance units: false
type: Species

metaR CITt4 2
is: SBO:0000185
modifier: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9058.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:8946005,PMID:8967342 NOTES:NCD
reactant: MODEL1310110003#
reversible: true
name: citrate transport via sodium symport
fast: false
type: Reaction
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_3b16def8_3d2d_4db6_b167_5dd320ce8c0d
name: ACADM
is: P11310
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:34
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaR RIBt2
reactant: MODEL1310110003#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
type: Reaction
is described by: ECO:0000000
name: ribose transport in via proton symporter
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: false

metaM thbpt4acam c
is: SBO:0000247
name: 4a-hydroxytetrahydrobiopterin
initial amount: NaN
is: HMDB02281
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:15374
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951

http://identifiers.org/biomodels.db/MODEL1310110003#_905f1bdd_4b16_4d87_a6d6_db1a8c5db434
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:27306
is: O60760
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
name: HPGDS
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_05901635_78f5_4783_9c7e_117d4902d40a
constant: false
initial concentration: NaN
initial amount: NaN
is: Q9H2U2
name: PPA2
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:27068

http://identifiers.org/biomodels.db/MODEL1310110003#_b0ab4f82_747a_4fa0_8cf4_08efbe6be787
is: SBO:0000252
is encoded by: hsa:2746
initial amount: NaN
name: GLUD1
is: E9KL48
constant: false
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

metaR r1527
kinetic law: MODEL1310110003#
reversible: false
is: SBO:0000185
reactant: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110003#
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.1
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:

metaR RPEc
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
reversible: true
reactant: MODEL1310110003#
name: ribulose 5-phosphate 3-epimerase
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
kinetic law: MODEL1310110003#
product: MODEL1310110003#

metaM prostge2 c
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: prostaglandin E2(1-)
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: CHEBI:606564
is: HMDB01220
constant: false
has only substance units: false

metaM dopa c
is: SBO:0000247
is: CHEBI:59905
initial amount: NaN
name: dopaminium(1+)
is: HMDB00073
constant: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false

metaR r0789
kinetic law: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
is: SBO:0000176
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.14.13.15

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

metaR 1PPDCRp
reactant: MODEL1310110003#
fast: false
type: Reaction
is: SBO:0000176
reversible: false
name: delta1-piperideine-2-carboxylate reductase, perixosomal
product: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
kinetic law: MODEL1310110003#

metaM HC02203 c
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:27820
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
name: prostaglandin-a2
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

metaM 4hphac c
name: 4-hydroxyphenylacetate
initial amount: NaN
is: HMDB00020
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
is: CHEBI:48999

metaM udpglcur c
initial amount: NaN
is: CHEBI:58052
name: UDP-D-glucuronate
constant: false
is: C00167
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00935

metaM glyb c
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:17750
initial amount: NaN
is: SBO:0000247
is: HMDB00043
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
constant: false
boundary condition: false
name: glycine betaine

http://identifiers.org/biomodels.db/MODEL1310110003#_f106dee3_9bc5_4bb3_aa87_d590d66e51f9
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
name: ALDH4A1
constant: false
has only substance units: false
is encoded by: hsa:8659
is: P30038
boundary condition: true

metaR NODe
kinetic law: MODEL1310110003#
type: Reaction
fast: false
reactant: MODEL1310110003#
product: MODEL1310110003#
name: NODe
reversible: true
is: SBO:0000185
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM m2mn l
initial amount: NaN
is: HMDB06537
initial concentration: 1.0
type: Species
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_9816f993_2ece_4735_b08a_5b13bb0e6b0e
constant: false
type: Species
is encoded by: hsa:6240
is: SBO:0000252
name: RRM1
is: P23921
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR GCC2am
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
name: glycine-cleavage complex (lipoamide), mitochondrial
reversible: true
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/2.1.2.10

http://identifiers.org/biomodels.db/MODEL1310110003#_cfdd97c7_ce72_4c13_ace0_598e99fbe9be
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:6482
type: Species
name: ST3GAL1
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_0d5483a8_fdee_450d_a845_30cc478a41df
initial concentration: NaN
is encoded by: hsa:D87002
type: Species
name: _D87002_1_m
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false

metaM cys L c
initial concentration: 1.0
name: L-cysteine
boundary condition: false
has only substance units: false
is: HMDB00574
is: SBO:0000247
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: CHEBI:17561
constant: false
initial amount: NaN
type: Species

metaM malcoa e
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: malonyl-CoA(4-)
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
type: Species
is: HMDB01175
boundary condition: false
is: CHEBI:57384
initial concentration: 1.0

metaM aps c
has only substance units: false
type: Species
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
initial amount: NaN
is: HMDB01003
constant: false
is: CHEBI:58243
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 5'-adenylyl sulfate(2-)

metaM ksi pre5 g
has only substance units: false
initial concentration: 1.0
is: CHEBI:28067
initial amount: NaN
constant: false
notes: FORMULA: C101H164N7O75SX CHARGE: -2
name: keratan sulfate I biosynthesis, precursor 5
is: SBO:0000247
type: Species
boundary condition: false

metaR r0407
fast: false
product: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.5
reversible: true
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
name: Sedoheptulose 1,7-bisphosphate D-glyceraldehyde-3-phosphate-lyase Carbon fixation EC:4.1.2.13
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 4.1.2.13 Confidence Level: 0 AUTHORS: PMID:10214945,PMID:2198022,PMID:4052378,PMID:4084320,PMID:6952783 NOTES:
type: Reaction

metaM glyc3p c
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB00126
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: Glycerol 3-phosphate
is: C00093
constant: false
is: CHEBI:57597

metaR PMTCOAtx
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
kinetic law: MODEL1310110003#
reversible: true
type: Reaction
reactant: MODEL1310110003#
product: MODEL1310110003#
name: fatty acid intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110003#_0751eb0b_6927_4485_afce_8d0bc65c1bf8
constant: false
is encoded by: hsa:175
initial amount: NaN
initial concentration: NaN
type: Species
is: P20933
boundary condition: true
is: SBO:0000252
name: AGA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_98aaf926_0ff8_43ea_91c2_61feb7f14bd7
type: Species
is encoded by: hsa:4713
name: NDUFB7
is: P17568
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_f2d8c8ae_aa2f_42b4_880a_15ac7202dea8
is encoded by: hsa:4696
constant: false
name: NDUFA3
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: O95167
has only substance units: false
initial concentration: NaN

metaM ps hs c
initial amount: NaN
type: Species
is: CHEBI:18303
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
constant: false
name: ps_hs[c]
boundary condition: false

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

metaR DHCRD1
modifier: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
name: dihydroceramide desaturase
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110003#_2609dcbb_8b11_44ab_a367_92bcc8594359
has only substance units: false
is encoded by: hsa:9154
boundary condition: true
type: Species
initial amount: NaN
is: O00337
name: SLC28A1
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_9f520e9c_a2ec_4936_be63_dd90956f2c72
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5167
is: P22413
constant: false
name: ENPP1
has only substance units: false
is: SBO:0000252
type: Species

metaR PGLer
is: SBO:0000176
is described by: ECO:0000269
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.47
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
product: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
name: 6-phosphogluconolactonase, endoplasmic reticulum
kinetic law: MODEL1310110003#

metaM prostge2 e
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
name: prostaglandin E2(1-)
is: HMDB01220
is: CHEBI:606564
constant: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: SBO:0000247

metaR AICART
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000269
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.1.2.3
name: phosphoribosylaminoimidazolecarboxamide formyltransferase

http://identifiers.org/biomodels.db/MODEL1310110003#_713ba51b_f38c_4e27_b79a_0532167053c1
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is: Q8IZV5
initial concentration: NaN
name: RDH10
is encoded by: hsa:157506
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_2783f29c_5896_422a_9506_98b5debad8a7
is: SBO:0000252
is encoded by: hsa:2582
type: Species
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: Q38G75
initial amount: NaN
name: GALE

metaM ps hs e
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:18303
boundary condition: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
constant: false
name: phosphatidylserine
type: Species
initial amount: NaN

metaM CE4876 r
name: delta12-Prostaglandin J2
boundary condition: false
is: CHEBI:15748
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00127
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_6c7b05c8_0c66_4fcd_990d_0c5f0f528856
initial amount: NaN
is encoded by: hsa:6549
name: SLC9A2
is: Q9UBY0
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species

metaM HC02203 e
initial concentration: 1.0
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
is: CHEBI:27820
type: Species
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: prostaglandin-a2

metaM dopa e
is: SBO:0000247
has only substance units: false
is: HMDB00073
boundary condition: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:59905
name: dopaminium(1+)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_c62c805c_a671_4b9a_85ba_8254344041fc
is: O00483
boundary condition: true
is encoded by: hsa:4697
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: NDUFA4
initial amount: NaN
initial concentration: NaN

metaR r0408
reactant: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
name: ATP:Sedoheptulose 7-phosphate 1-phosphotransferase EC:2.7.1.11
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.4.3.5
reversible: true
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (AI934540.1) or (55163.1) or (W74642.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:4084320,PMID:4272358 NOTES:

metaR ILETAm
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
modifier: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
reversible: true
reactant: MODEL1310110003#
name: isoleucine transaminase, mitochondrial
type: Reaction
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_9be86540_dcb8_421b_81de_810ae70992d3
boundary condition: true
constant: false
is encoded by: hsa:7108
name: TM7SF2
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: O76062

metaM succ e
name: succinate(2-)
type: Species
is: HMDB00254
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
initial concentration: 1.0
constant: false
is: CHEBI:30031
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247

metaR r0630
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
reversible: true
modifier: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.2
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.3.1
is: SBO:0000176

metaR EX 34dhphe LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxy-L-phenylalanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_6a04a023_4947_4dd5_9755_59f66237c59c
type: Species
is encoded by: hsa:4728
boundary condition: true
name: NDUFS8
constant: false
is: O00217
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR RETFA
is: SBO:0000176
fast: false
name: retinol acyltransferase
type: Reaction
reactant: MODEL1310110003#
reversible: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT

metaR RE1573M
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
name: RE1573
fast: false
product: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.8

metaR MG1er
reversible: false
is: SBO:0000176
modifier: MODEL1310110003#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
fast: false
type: Reaction
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (7841.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.106 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.2.1.106
product: MODEL1310110003#

metaR FAOXC16080m
is described by: ECO:0000269
reversible: false
is: SBO:0000176
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110003#
name: Beta oxidation of long chain fatty acid
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110003#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_d8fb9787_8d8d_4135_968b_37ef4782042d
name: GALNS
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2588
is: P34059
has only substance units: false
type: Species
initial concentration: NaN
constant: false
boundary condition: true

metaM 44mctr r
is: CHEBI:17813
initial concentration: 1.0
type: Species
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
constant: false
is: HMDB01023
initial amount: NaN
has only substance units: false
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
is: SBO:0000247
boundary condition: false

metaR r1647
product: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR r2145
kinetic law: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110003#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
fast: false

metaR 2AMADPTm
type: Reaction
kinetic law: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
fast: false
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
is described by: ECO:0000269
reactant: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185

metaM arachcrn m
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB06460
has only substance units: false
name: arachidyl carnitine
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_0d2a1eff_9a9e_4c11_99df_92336720a177
has only substance units: false
is: B3KVI7
name: IVD
is encoded by: hsa:3712
type: Species
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252

metaR L LACt2r
type: Reaction
reversible: true
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:11827462,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
name: L-lactate reversible transport via proton symport
product: MODEL1310110003#
is described by: ECO:0000269
kinetic law: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
is: SBO:0000185

metaM thf c
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
has only substance units: false
is: HMDB01846
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
name: 5,6,7,8-Tetrahydrofolate
is: C00101
type: Species
is: CHEBI:57453
boundary condition: false

metaM cys L e
name: L-cysteine
is: HMDB00574
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C3H7NO2S CHARGE: 0 INCHI: InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00099
is: CHEBI:17561

http://identifiers.org/biomodels.db/MODEL1310110003#_9be96836_dd81_4703_9a3a_44f993fded22
name: ALPP
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is: P05187
initial amount: NaN
is encoded by: hsa:250

http://identifiers.org/biomodels.db/MODEL1310110003#_f7adca7b_44e7_4b26_b588_a5f830b2a54f
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:BF195998
name: _BF195998_1_x
is: SBO:0000252
constant: false
initial amount: NaN

metaR TCYNTtm
fast: false
kinetic law: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
name: Thiocyanate transport via diffusion (mitochondrial)
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
is described by: ECO:0000000
is: SBO:0000185
reversible: false

metaR GLACter
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
name: D-glucurono-6,3-lactone transport, endoplasmic reticulum
is described by: ECO:0000000
product: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:3779687 NOTES:NCD
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_62a5e7fc_1ec0_41a5_a6ad_9c1b22aacdbc
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:55350
type: Species
initial concentration: NaN
name: VNN3
initial amount: NaN
constant: false

metaM zymst r
has only substance units: false
name: zymosterol
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01451 EHMN_ABBREVIATION: C05437
boundary condition: false
initial concentration: 1.0
is: HMDB06271
is: SBO:0000247
initial amount: NaN
is: CHEBI:18252
constant: false

metaR PPCOAOm
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
kinetic law: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
fast: false
reversible: false
reactant: MODEL1310110003#
modifier: MODEL1310110003#

metaR HIStN1
name: Histidine transport (Na, H coupled)
reactant: MODEL1310110003#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
product: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
is described by: ECO:0000269
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_54760264_f8d3_4f2e_a695_15c614ec705d
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:128
initial concentration: NaN
is: Q6IRT1
initial amount: NaN
is: SBO:0000252
constant: false
name: ADH5

metaR UMPK
fast: false
reversible: true
kinetic law: MODEL1310110003#
name: UMP kinase
type: Reaction
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176

metaR G14T13g
modifier: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reactant: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000176
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaM ppa e
boundary condition: false
is: HMDB00237
is: CHEBI:17272
initial amount: NaN
constant: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
initial concentration: 1.0
has only substance units: false
name: propionate
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_6f3876e5_06f5_4709_9943_a361f22cdcb4
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:54963
is: Q53HM1
is: SBO:0000252
name: UCKL1
initial amount: NaN
initial concentration: NaN
type: Species

metaR r2144
kinetic law: MODEL1310110003#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true

metaR CHOLtr
kinetic law: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: choline intracellular transport
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
reversible: true

metaR r1648
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110003#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_15736699_c357_4e1a_8131_8d069fe8c970
boundary condition: true
type: Species
is encoded by: hsa:55902
initial concentration: NaN
name: ACSS2
initial amount: NaN
constant: false
is: Q96FY7
is: SBO:0000252
has only substance units: false

metaR RE2799C
product: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
reactant: MODEL1310110003#
type: Reaction
reversible: true
name: RE2799
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110003#

metaM dcyt n
has only substance units: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
is: SBO:0000247
initial amount: NaN
name: 2'-deoxycytidine
is: HMDB00014
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:15698

metaR ORNtiDF
notes: GENE_ASSOCIATION: (6542.1) or (6541.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
name: ornithine transport via diffusion (extracellular to cytosol)
fast: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110003#
reversible: false
product: MODEL1310110003#

metaM orn m
name: Ornithine
is: C01602
type: Species
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
initial concentration: 1.0
has only substance units: false
is: CHEBI:46912
is: SBO:0000247
is: HMDB00214

metaM crn x
initial amount: NaN
is: HMDB00062
is: C00318
is: SBO:0000247
initial concentration: 1.0
name: L-Carnitine
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
has only substance units: false
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_26921b36_d90a_40e2_a821_ad204885b5f6
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is: P43007
name: SLC1A4
is encoded by: hsa:6509
initial amount: NaN
has only substance units: false

metaR r0483
reversible: true
product: MODEL1310110003#
reactant: MODEL1310110003#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_670b5585_44ed_44d3_b208_736e3b2a5d4c
is: SBO:0000252
constant: false
is: E7ET30
initial amount: NaN
name: AK3
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:50808
has only substance units: false

metaM succ c
is: HMDB00254
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
boundary condition: false
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:30031
name: Succinate
is: SBO:0000247
is: C00042

http://identifiers.org/biomodels.db/MODEL1310110003#_b1ab5392_4c37_4262_b90a_8f10f2a1150f
name: ACOT2
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:10965
initial amount: NaN
constant: false
is: SBO:0000252
is: P49753

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

metaR r1649
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110003#
type: Reaction
reversible: true
modifier: MODEL1310110003#
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_22a30317_b885_4ff5_90a3_555a27b24411
initial amount: NaN
has part: P23434
has part: P48728
has only substance units: false
has part: P23378
initial concentration: NaN
is encoded by: hsa:2653
boundary condition: true
is encoded by: hsa:2731
is: SBO:0000297
constant: false
name: DLD:GCSH:GLDC:AMT
is encoded by: hsa:275
has part: P09622
is encoded by: hsa:1738
type: Species

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_6815659a_71ff_47bb_8c58_62c6d33136a0
is: SBO:0000252
name: SGPL1
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:8879
initial concentration: NaN
type: Species
is: O95470

metaR DOLPMT3 Uer
fast: false
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.260
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110003#
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000000

metaM thf e
boundary condition: false
is: HMDB01846
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
type: Species
is: CHEBI:57453

http://identifiers.org/biomodels.db/MODEL1310110003#_46984523_5b96_4efb_aebe_49469a33f57f
is encoded by: hsa:1103
has only substance units: false
is: Q6LEN6
boundary condition: true
initial amount: NaN
name: CHAT
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

metaR DPMVDc
name: diphosphomevalonate decarboxylase, cytosol
reversible: false
notes: GENE_ASSOCIATION: (4597.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added t product for elemental balancing.
is: SBO:0000176
type: Reaction
reactant: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.1.1.33
is described by: ECO:0000134
kinetic law: MODEL1310110003#
product: MODEL1310110003#

metaR CITt4 4
type: Reaction
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
is described by: ECO:0000006
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true
name: citrate transport via sodium symport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_76f7e5d2_f1eb_4668_98f6_884446f451ac
type: Species
is encoded by: hsa:AI761708
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: _AI761708_1_m
initial concentration: NaN
constant: false

metaR r1375
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
type: Reaction
product: MODEL1310110003#
name: Transport reaction
reactant: MODEL1310110003#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110003#_836da970_1655_4ec7_91a7_1d9b8002ebef
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:10559
is: P78382
name: SLC35A1
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

metaR CHOLPtg
reversible: true
reactant: MODEL1310110003#
fast: false
is described by: ECO:0000000
product: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - no strong evidence to indicate further lysosomal or golgi metabolism NJ
name: choline phosphate intracellular transport

metaM hdcea e
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB03229
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:32372
name: Hexadecenoate (n-C16:1)

metaR r1754
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
modifier: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
product: MODEL1310110003#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#

metaR NTD7
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
is version of: http://identifiers.org/ec-code/3.1.3.5
name: 5'-nucleotidase (AMP)
product: MODEL1310110003#
type: Reaction
reversible: false
reactant: MODEL1310110003#
fast: false
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#

metaR r1755
product: MODEL1310110003#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
fast: false
reactant: MODEL1310110003#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110003#_93978fe6_da00_4df3_9bf9_e523e27ddeb9
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10905
is: SBO:0000252
initial amount: NaN
name: MAN1A2
type: Species
is: O60476
boundary condition: true
constant: false

metaM 2oxoadp m
is: HMDB00225
boundary condition: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
name: 2-oxoadipate(2-)
is: CHEBI:57499

metaM ksi pre26 g
is: SBO:0000247
constant: false
name: keratan sulfate I biosynthesis, precursor 26
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
type: Species
boundary condition: false
is: CHEBI:28067
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM ala D x
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:15570
is: HMDB01310
name: D-alanine
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
constant: false

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

metaR G5SADrm
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: true
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
fast: false
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110003#

metaR PPD2CSPp
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
reactant: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reversible: false
product: MODEL1310110003#
name: PPD2CSPp
fast: false
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_aff0a40d_9bb2_483f_bb6f_a6a5eb52361e
boundary condition: true
name: _LOC374569_1_e
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:LOC374569

metaM 4aphdob c
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
boundary condition: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
has only substance units: false
is: HMDB00978
is: CHEBI:58147
initial concentration: 1.0
initial amount: NaN

metaR r2142
reactant: MODEL1310110003#
product: MODEL1310110003#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
modifier: MODEL1310110003#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
fast: false
kinetic law: MODEL1310110003#
type: Reaction

metaM xol7aone c
boundary condition: false
is: CHEBI:17899
name: 7alpha-hydroxycholest-4-en-3-one
initial amount: NaN
is: HMDB01993
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
is: SBO:0000247
type: Species
constant: false

metaR r1374
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
type: Reaction
name: EC:3.2.1.14
fast: false
product: MODEL1310110003#
reversible: false
is described by: ECO:0000000

metaM gua c
boundary condition: false
is: HMDB00132
type: Species
initial concentration: 1.0
is: C00242
is: CHEBI:16235
has only substance units: false
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: SBO:0000247
initial amount: NaN
name: Guanine
constant: false

metaR r1487
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
product: MODEL1310110003#
name: EC:6.2.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: true

metaR EX ins LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Inosine exchange
type: Reaction

metaR GARFT
reversible: true
type: Reaction
reactant: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
modifier: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000176
name: phosphoribosylglycinamide formyltransferase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.2

metaM HC01403 m
is: CHEBI:28325
name: (S)-Hydroxydecanoyl-CoA
initial amount: NaN
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_d8cfde9f_89c5_4379_a7ef_551ed41df9de
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:18
type: Species
has only substance units: false
name: ABAT

metaM glyb e
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
initial amount: NaN
name: glycine betaine
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00043
is: SBO:0000247
constant: false
type: Species
is: CHEBI:17750

metaR S6T12g
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110003#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
reversible: false

metaM gchola x
type: Species
notes: FORMULA: C26H43NO6 CHARGE: 0 INCHI: InChI=1S/C26H43NO6/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33)/p-1/t14-,15+,16-,17-,18+,19+,20-,21+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
is: SBO:0000247
name: glycocholate
boundary condition: false
has only substance units: false
is: HMDB00138
constant: false
is: CHEBI:58235
initial amount: NaN
initial concentration: 1.0

metaM 4hphac e
initial amount: NaN
name: 4-hydroxyphenylacetate
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:48999
is: HMDB00020
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_d340c17a_591f_4a82_8697_a1a68c5884c1
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:115584
is: Q8WWX8
type: Species
initial amount: NaN
is: SBO:0000252
name: SLC5A11
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_5a4ff1c8_1919_41e6_b8df_63d0faf1409a
type: Species
is: P21589
is: SBO:0000252
initial amount: NaN
constant: false
name: NT5E
has only substance units: false
is encoded by: hsa:4907
boundary condition: true
initial concentration: NaN

metaM tcynt c
name: thiocyanate
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
initial amount: NaN
is: CHEBI:18022
is: SBO:0000247
type: Species
is: HMDB01453

metaM fn2m2masn g
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
is: CHEBI:32984
type: Species
boundary condition: false
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
has only substance units: false
constant: false

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_0866df49_ffa0_4f17_8dfb_7460483e7fd3
initial amount: NaN
constant: false
has only substance units: false
name: UCP2
is: SBO:0000252
is: P55851
initial concentration: NaN
boundary condition: true
is encoded by: hsa:7351
type: Species

metaM arg L m
type: Species
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial concentration: 1.0
is: HMDB00517
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
name: L-argininium(1+)
is: SBO:0000247
is: CHEBI:32682

http://identifiers.org/biomodels.db/MODEL1310110003#_e685ce66_8636_4dcc_b4bb_486d48bbaa69
initial concentration: NaN
is encoded by: hsa:6185
type: Species
is: P04844
boundary condition: true
initial amount: NaN
name: RPN2
is: SBO:0000252
constant: false
has only substance units: false

metaM C05279 m
constant: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false
is: CHEBI:28387
boundary condition: false
is: SBO:0000247
name: trans,cis-Lauro-2,6-dienoyl-CoA
is: HMDB11123

http://identifiers.org/biomodels.db/MODEL1310110003#_f3cc9976_2f90_4e63_84b9_ca408643bd2a
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: P22352
is encoded by: hsa:2878
name: GPX3
is: SBO:0000252

metaM crn c
is: C00318
has only substance units: false
is: HMDB00062
name: L-Carnitine
constant: false
type: Species
is: CHEBI:16347
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaR r2089
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
product: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110003#

metaR r2006
product: MODEL1310110003#
fast: false
reversible: false
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
is: SBO:0000185

metaM gdpmann c
has only substance units: false
initial concentration: 1.0
is: CHEBI:57527
name: GDP-alpha-D-mannose(2-)
initial amount: NaN
is: SBO:0000247
is: HMDB01163
type: Species
boundary condition: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_c9ab6c3a_9ebf_4942_812c_62546fbbe01c
type: Species
initial concentration: NaN
is: SBO:0000252
is: O00400
is encoded by: hsa:9197
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: SLC33A1

metaM betald c
boundary condition: false
is: CHEBI:15710
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
name: betaine aldehyde
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
constant: false
initial amount: NaN
is: HMDB01252

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM core6 l
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: SBO:0000247
has only substance units: false
is: CHEBI:12936
boundary condition: false
constant: false
type: Species
is: HMDB00143
name: Core 6
initial amount: NaN
initial concentration: 1.0

metaR UMPK6
type: Reaction
reversible: true
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110003#
modifier: MODEL1310110003#
name: UMP kinase (dCTP)

metaM uacgam g
boundary condition: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
type: Species
constant: false
is: HMDB00290
is: SBO:0000247
is: CHEBI:57705
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_b6f9a5aa_9109_4c6e_b737_1c4c326a50e7
name: SLC17A5
type: Species
initial amount: NaN
is: Q9NRA2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:26503
has only substance units: false
initial concentration: NaN
constant: false

metaM CE4794 m
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
initial amount: NaN
is: SBO:0000247
is: HMDB00127
constant: false
is: CHEBI:15748
name: cis-6-dodecenoyl-CoA
has only substance units: false

metaR r2366
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
type: Reaction
kinetic law: MODEL1310110003#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_58612cf5_3c08_4fe0_b154_7f706be4c8bd
boundary condition: true
type: Species
is: Q5JT09
initial amount: NaN
name: UCK1
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:83549
has only substance units: false

metaM clpndcoa c
name: clupanodonyl CoA
is: HMDB06267
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
constant: false
has only substance units: false
is: C16166
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205476
initial concentration: 1.0

metaM icit m
initial concentration: 1.0
initial amount: NaN
name: Isocitrate
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00193
constant: false
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: C00311
is: CHEBI:16087

http://identifiers.org/biomodels.db/MODEL1310110003#_e01f6597_afd4_4cce_bbc6_2e3db5fed112
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:622
name: BDH1

metaM glcur l
is: HMDB00127
constant: false
name: D-glucuronate
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
has only substance units: false
type: Species

metaM taur x
is: CHEBI:15891
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C2H7NO3S CHARGE: 0 INCHI: InChI=1S/C2H7NO3S/c3-1-2-7(4,5)6/h1-3H2,(H,4,5,6) HEPATONET_1.0_ABBREVIATION: HC00222 EHMN_ABBREVIATION: C00245
name: taurine
boundary condition: false
type: Species
is: HMDB00251

http://identifiers.org/biomodels.db/MODEL1310110003#_924db991_d9ec_45a4_9a36_1f5fcbdc987f
is: SBO:0000252
is encoded by: hsa:2720
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: GLB1
has only substance units: false
is: P16278
constant: false
type: Species

metaR GLNt4
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB
kinetic law: MODEL1310110003#
name: L-glutamine reversible transport via sodium symport
product: MODEL1310110003#
reversible: false
modifier: MODEL1310110003#
fast: false
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110003#
is: SBO:0000185

metaM ru5p D c
is: HMDB00618
initial amount: NaN
name: D-ribulose 5-phosphate(2-)
is: SBO:0000247
is: CHEBI:58121
type: Species
has only substance units: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
initial concentration: 1.0
boundary condition: false
constant: false

metaR NOt
is described by: ECO:0000000
kinetic law: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
reversible: true
reactant: MODEL1310110003#
is: SBO:0000185
fast: false
name: NO transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaR r2367
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110003#
fast: false
type: Reaction
reversible: true
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110003#

metaR MANt1r
modifier: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
name: mannose transport (uniport)
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD
type: Reaction
product: MODEL1310110003#

metaR UMPK7
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (dGTP)
fast: false
is: SBO:0000176
modifier: MODEL1310110003#
is described by: ECO:0000269
reversible: true

metaM hco3 c
is: CHEBI:17544
name: Bicarbonate
initial amount: NaN
boundary condition: false
type: Species
is: C00288
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: SBO:0000247
has only substance units: false
is: HMDB00595
initial concentration: 1.0
constant: false

metaR r0267
reactant: MODEL1310110003#
type: Reaction
reversible: true
kinetic law: MODEL1310110003#
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.9
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
product: MODEL1310110003#
is: SBO:0000176
fast: false
modifier: MODEL1310110003#

metaM tcynt e
type: Species
is: HMDB01453
initial amount: NaN
initial concentration: 1.0
name: thiocyanate
constant: false
boundary condition: false
is: CHEBI:18022
is: SBO:0000247
has only substance units: false
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaM 34dhmald m
type: Species
is: C05577
is: HMDB06242
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/7903
initial amount: NaN
has only substance units: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: SBO:0000247
name: 3,4-Dihydroxymandelaldehyde
constant: false

metaR 3DSPHR
is version of: http://identifiers.org/ec-code/1.1.1.102
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110003#
reactant: MODEL1310110003#
name: 3-Dehydrosphinganine reductase
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
fast: false

metaR EX n2m2nmasn LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R exchange
type: Reaction

metaM HC00361 c
type: Species
has only substance units: false
name: sedoheptulose 1,7-bisphosphate(4-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C7H12O13P2 CHARGE: -4 INCHI: InChI=1S/C7H16O13P2/c8-3(1-19-21(13,14)15)5(10)7(12)6(11)4(9)2-20-22(16,17)18/h3,5-8,10-12H,1-2H2,(H2,13,14,15)(H2,16,17,18)/p-4/t3-,5-,6-,7-/m1/s1 EHMN_ABBREVIATION: C00447
initial amount: NaN
is: CHEBI:58335
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_9ef2d120_303d_4364_9a1c_7808d305802d
initial amount: NaN
is encoded by: hsa:92483
name: LDHAL6B
is: Q9BYZ2
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false

metaR UGCG
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
reversible: false
fast: false
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.80
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
name: Ceramide glucosyltransferase
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_a6f6f273_ec0e_400f_aea4_2149c2d9c529
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
name: PANK3
is: Q9H999
is encoded by: hsa:79646
constant: false
type: Species
is: SBO:0000252

metaR HEX10
modifier: MODEL1310110003#
product: MODEL1310110003#
reversible: false
fast: false
is described by: ECO:0000212
is: SBO:0000176
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
is version of: http://identifiers.org/ec-code/2.7.1.2
reactant: MODEL1310110003#
name: hexokinase (D-glucosamine:ATP)
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.1.1
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_cf559646_0816_42da_a301_09afe35414ec
initial amount: NaN
has only substance units: false
is: Q96P26
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
name: NT5C1B
is encoded by: hsa:93034

metaR 3MOX4HOXPGALDOX
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NAD+ oxidoreductase
reversible: false
is: SBO:0000176
modifier: MODEL1310110003#
fast: false
is described by: ECO:0000304
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#

metaR r0027
is version of: http://identifiers.org/ec-code/1.14.13.39
kinetic law: MODEL1310110003#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110003#
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
modifier: MODEL1310110003#
reversible: true
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
product: MODEL1310110003#

metaM HC01496 m
type: Species
constant: false
is: CHEBI:28095
name: 2-Amino-3-oxoadipate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
is: SBO:0000247
boundary condition: false
has only substance units: false

metaR PCm
reversible: false
kinetic law: MODEL1310110003#
name: pyruvate carboxylase
modifier: MODEL1310110003#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/6.4.1.1
product: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
is: SBO:0000176

metaR O2ter
fast: false
reactant: MODEL1310110003#
reversible: true
is: SBO:0000185
name: O2 transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_c052047f_1455_434c_880b_65a2172b6b71
is: Q16222
initial amount: NaN
type: Species
is encoded by: hsa:6675
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: UAP1
constant: false

metaM galgluside hs g
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
boundary condition: false
is: C00015
constant: false
initial concentration: 1.0
type: Species
is: HMDB00295
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: galactosyl glucosyl ceramide
is: CHEBI:58223

metaM 4hpro LT m
is: CHEBI:18095
boundary condition: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: trans-4-hydroxy-L-proline
constant: false
is: HMDB00725

metaR r2364
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110003#
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR r0268
is version of: http://identifiers.org/ec-code/3.1.3.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
type: Reaction
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.3.1
fast: false
reversible: true
reactant: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2

metaM 13 cis retn r
boundary condition: false
is: HMDB06219
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
is: SBO:0000247
name: 13-cis-retinoate
is: D00348
is: http://identifiers.org/pubchem.compound/7847414
has only substance units: false
constant: false

metaM idour l
is: HMDB02704
is: CHEBI:21338
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
name: L-iduronate
initial amount: NaN
boundary condition: false
has only substance units: false

metaR GLUPRT
name: glutamine phosphoribosyldiphosphate amidotransferase
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.14
product: MODEL1310110003#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
kinetic law: MODEL1310110003#
is: SBO:0000176
modifier: MODEL1310110003#
reactant: MODEL1310110003#
fast: false

metaM hco3 e
initial concentration: 1.0
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
is: HMDB00595
initial amount: NaN
has only substance units: false
is: C00288
is: CHEBI:17544
boundary condition: false
type: Species
is: SBO:0000247
name: Bicarbonate
constant: false

metaM pmtcrn r
has only substance units: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
constant: false
is: HMDB00222
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: L-palmitoylcarnitine
type: Species
is: CHEBI:17490

metaR 3HCO3 NAt
type: Reaction
name: 3HCO3_NAt
is: SBO:0000185
fast: false
is described by: ECO:0000134
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
reversible: true
kinetic law: MODEL1310110003#

metaR PAPtg
product: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
name: adenosine 3',5'-bisphosphate Golgi transport
reactant: MODEL1310110003#
fast: false

metaR RE0452M
type: Reaction
kinetic law: MODEL1310110003#
name: RE0452
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
fast: false
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110003#
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_1325c0c1_a3e3_4e46_80ec_8901dfb57ec1
constant: false
has only substance units: false
is encoded by: hsa:5730
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
name: PTGDS
is: SBO:0000252
is: P41222

metaR r2365
name: Organic anion transporter 5 Utilized transport
reversible: true
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_b48b05a4_f428_458f_bb0c_1fec5e193e8c
constant: false
initial concentration: NaN
initial amount: NaN
name: ACAD11
boundary condition: true
is: SBO:0000252
is encoded by: hsa:84129
is: Q709F0
has only substance units: false
type: Species

metaM dhdascb c
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
initial concentration: 1.0
is: CHEBI:58070
is: HMDB01264
has only substance units: false
boundary condition: false
is: SBO:0000247
name: dehydroascorbide(1-)

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR DITPtn
kinetic law: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110003#
fast: false
reversible: true
name: dITP nuclear transport
is: SBO:0000185
product: MODEL1310110003#

metaR r0021
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000000
reactant: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
reversible: true
type: Reaction
kinetic law: MODEL1310110003#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_ac5defed_6896_4acb_b947_0cc215f7f4f8
initial amount: NaN
initial concentration: NaN
is: Q53YB7
constant: false
name: COX5B
boundary condition: true
is encoded by: hsa:1329
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_280a9dc1_ca70_476e_8500_90803c2f0540
name: IK
initial amount: NaN
is: Q13123
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:3550

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR SERDGLYexR
is described by: ECO:0000304
product: MODEL1310110003#
kinetic law: MODEL1310110003#
name: D-Serine/Glycine reversible exchange
reversible: true
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110003#
type: Reaction
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_884fe0e1_04f1_4d76_9146_23c28551fa20
boundary condition: true
has only substance units: false
initial amount: NaN
name: PLCD3
constant: false
type: Species
is encoded by: hsa:113026
initial concentration: NaN
is: SBO:0000252
is: Q8N3E9

metaR r0265
type: Reaction
product: MODEL1310110003#
reversible: false
kinetic law: MODEL1310110003#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:8908517 NOTES:
is: SBO:0000176
name: ATP:D-galactose 1-phosphotransferase Galactose metabolism EC:2.7.1.6
reactant: MODEL1310110003#

metaR BDHm
kinetic law: MODEL1310110003#
product: MODEL1310110003#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
is: SBO:0000176
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.30
fast: false
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_d1751db7_b458_4281_8794_1ab809c44fe6
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:123041
name: SLC24A4
boundary condition: true
is: Q8NFF2
is: SBO:0000252
initial amount: NaN
type: Species

metaR UDPDOLPT U
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
modifier: MODEL1310110003#
reversible: false
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.117
fast: false
is described by: ECO:0000000

metaM uacgam c
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
type: Species
constant: false
is: HMDB00290
has only substance units: false
initial concentration: 1.0
is: CHEBI:57705

metaM retinal c
is: SBO:0000247
boundary condition: false
is: HMDB01358
is: CHEBI:15035
initial amount: NaN
type: Species
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
name: retinal
initial concentration: 1.0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_6697f591_2f89_4b18_9529_56f579520cb9
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:788
has only substance units: false
name: SLC25A20
type: Species
is: O43772
initial amount: NaN
constant: false

metaR r2085
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110003#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
fast: false
product: MODEL1310110003#
reversible: true

metaR S23T2g
type: Reaction
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110003#
is: SBO:0000176
fast: false
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
reactant: MODEL1310110003#
reversible: false
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.99.4
product: MODEL1310110003#

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

metaR DCYTDn
kinetic law: MODEL1310110003#
name: deoxycytidine deaminase, nuclear
modifier: MODEL1310110003#
reversible: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:IT
is version of: http://identifiers.org/ec-code/3.5.4.5
fast: false
is described by: ECO:0000254
is: SBO:0000176
product: MODEL1310110003#
type: Reaction

metaR RE1533M
name: RE1533
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
kinetic law: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false

metaR r2362
fast: false
reversible: true
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#

metaM hs deg14 l
is: CHEBI:16126
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: heparan sulfate, degradation product 14
constant: false
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
has only substance units: false

metaM chlstol r
boundary condition: false
is: HMDB06842
is: CHEBI:16290
has only substance units: false
is: SBO:0000247
name: 5alpha-cholesta-7,24-dien-3beta-ol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR r2009
is described by: ECO:0000000
kinetic law: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110003#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
fast: false
product: MODEL1310110003#
modifier: MODEL1310110003#

metaM Rtotal3coa c
notes: FORMULA: CO2FULLR3C21H31N7O15P3S CHARGE: -4
boundary condition: false
is: CHEBI:16189
initial amount: NaN
initial concentration: 1.0
is: HMDB01448
name: R total 3 Coenzyme A
is: SBO:0000247
constant: false
type: Species
has only substance units: false

metaR r0022
is: SBO:0000176
modifier: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.8.1.7
fast: false
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is described by: ECO:0000000
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
kinetic law: MODEL1310110003#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_0c69d9f4_8a44_4c7f_8922_a546ebfa8718
is: O15305
is encoded by: hsa:5373
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: PMM2
initial amount: NaN
constant: false
has only substance units: false

metaM pmtcrn x
is: HMDB00222
name: L-palmitoylcarnitine
is: SBO:0000247
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
has only substance units: false
is: CHEBI:17490
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_99e68105_9a6d_44ac_a3c6_1691de397e0f
is: P26439
name: HSD3B2
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:3284
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM ksii core2 pre5 g
is: C00130
boundary condition: false
is: HMDB00175
type: Species
is: SBO:0000247
constant: false
name: keratan sulfate II biosynthesis, precursor 5
has only substance units: false
initial concentration: 1.0
is: CHEBI:58053
initial amount: NaN
notes: FORMULA: C61H99N5O43X CHARGE: -1

metaR MALtm
type: Reaction
name: malate transport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
modifier: MODEL1310110003#
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000269

metaM cmp e
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
is: HMDB00095
type: Species
name: CMP(2-)
is: CHEBI:60377
constant: false
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM co2 e
boundary condition: false
initial concentration: 1.0
is: C00011
type: Species
is: HMDB01967
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
constant: false
has only substance units: false
name: CO2
is: SBO:0000247
initial amount: NaN
is: CHEBI:16526

http://identifiers.org/biomodels.db/MODEL1310110003#_32710c22_778f_417e_afde_dcc8cd4313c6
constant: false
is encoded by: hsa:6522
initial amount: NaN
boundary condition: true
is: F8W682
type: Species
initial concentration: NaN
name: SLC4A2
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_4d998c4c_4fad_4a22_9c8a_00f89e3599fb
initial amount: NaN
type: Species
has only substance units: false
name: LPL
initial concentration: NaN
boundary condition: true
is: P06858
constant: false
is: SBO:0000252
is encoded by: hsa:4023

metaR MANter
name: mannose efflux from endoplasmic reticulum
product: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000

metaR CHSTEROLtrc
name: transport of cholesterol into the cytosol
is: SBO:0000185
fast: false
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.

metaM pail hs c
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
has only substance units: false
constant: false
name: 1-phosphatidyl-1D-myo-inositol(1-)
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:57880
initial concentration: 1.0
initial amount: NaN

metaM bilglcur r
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
constant: false
initial concentration: 1.0
is: CHEBI:57767
initial amount: NaN
name: mono(glucosyluronic acid)bilirubin(2-)
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_1e8a4dc5_98ab_4839_b0e7_9ad92f041b6d
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:9963
boundary condition: true
is: Q9UHI7
has only substance units: false
constant: false
initial concentration: NaN
name: SLC23A1

http://identifiers.org/biomodels.db/MODEL1310110003#_6c099aae_a2b7_45ae_95b0_df8ce5b1de5e
has only substance units: false
initial concentration: NaN
name: GALNT4
boundary condition: true
is encoded by: hsa:8693
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is: Q8N4A0

metaR r2363
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110003#

metaR r2086
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_5157f020_3759_48dc_90d9_652b747c6df1
name: _AI990637_1_x
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI990637
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_0b9df29d_d5d7_41ef_a9ba_81112d71c4e0
has only substance units: false
is encoded by: hsa:C7orf24
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: _C7orf24_1_m
type: Species
initial concentration: NaN
constant: false

metaR NDPK10n
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
type: Reaction
modifier: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
reactant: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
is: SBO:0000176

metaR r1156
fast: false
reversible: true
is: SBO:0000176
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
reactant: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
kinetic law: MODEL1310110003#

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaM glcur e
is: CHEBI:15748
boundary condition: false
initial amount: NaN
is: HMDB00127
name: D-glucuronate
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191

http://identifiers.org/biomodels.db/MODEL1310110003#_f7dc980c_b8bb_4888_857e_4afc040f0e4a
is: SBO:0000252
is encoded by: hsa:125206
name: SLC5A10
is: A0PJK1
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
type: Species

metaR H2CO3D
is: SBO:0000176
type: Reaction
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.1
product: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
fast: false
name: carboxylic acid dissociation
kinetic law: MODEL1310110003#
reversible: true
is described by: ECO:0000000

metaR GLCt1r
product: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000269
name: glucose transport (uniport)
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:

metaR G6PDH1rer
reversible: true
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.1.47
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
is: SBO:0000176
modifier: MODEL1310110003#
is described by: ECO:0000269
type: Reaction

metaR r1973
is: SBO:0000185
kinetic law: MODEL1310110003#
reversible: false
reactant: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110003#
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_e1ded18a_2785_49a3_bee5_0ce2f9a7bd46
initial amount: NaN
has only substance units: false
name: NDUFB5
is: O43674
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4711

metaR r2087
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: true
is: SBO:0000185
reactant: MODEL1310110003#

metaM cmp g
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP(2-)
initial concentration: 1.0
constant: false
is: CHEBI:60377
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB00095
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_be927665_1cad_4c08_8208_3f17b7bbc57a
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:79646
is: Q9H999
has only substance units: false
name: PANK3
is: SBO:0000252

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR CERT1rt
fast: false
is: SBO:0000185
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
name: ceramide transport protein
is described by: ECO:0000304
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
reversible: true

metaR PIPLCn
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.4.11
reversible: false
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
fast: false
is: SBO:0000176
name: phosphatidylinositol phospholipase C, nucleus
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
modifier: MODEL1310110003#
type: Reaction

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaR r2360
fast: false
reversible: true
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110003#
is: SBO:0000185
product: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110003#

metaR HMGCOAtm
is described by: ECO:0000000
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
fast: false
type: Reaction
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
reversible: true
is: SBO:0000185
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_c46b7c1b_ffed_4bc0_baf8_ecfa03d4fc6c
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: NDUFB10
constant: false
initial amount: NaN
is: A8K761
type: Species
is encoded by: hsa:4716

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_c7a99ed8_09b7_47b8_8212_7bdb3526e65b
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
name: DTYMK
initial concentration: NaN
type: Species
is encoded by: hsa:1841
is: P23919
initial amount: NaN

metaR SQLEr
is described by: ECO:0000134
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.14.13.132
reversible: false
type: Reaction
name: Squalene epoxidase, endoplasmic reticular (NADP)
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (6713.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.99.7 Confidence Level: 4 AUTHORS: PMID:1964954 NOTES:NCD
product: MODEL1310110003#
fast: false
is: SBO:0000176
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_19585a40_b3f0_42ea_befd_2640c39b4ad8
name: _728226_1_e
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:728226
has only substance units: false
boundary condition: true

metaR SPMTDe
is described by: ECO:0000134
type: Reaction
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: SPMTDe
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
reversible: true

metaM thf m
is: HMDB01846
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00101
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
type: Species
name: 5,6,7,8-Tetrahydrofolate
constant: false
is: CHEBI:57453

metaM ivcoa m
is: HMDB01113
boundary condition: false
is: CHEBI:57345
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
name: Isovaleryl-CoA
has only substance units: false
is: SBO:0000247
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939

http://identifiers.org/biomodels.db/MODEL1310110003#_5e3c879f_4b94_4161_90bc_7ddc41a04a11
is: Q8N5Z0
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:51166
initial amount: NaN
has only substance units: false
name: AADAT

metaR C3STKR2r
product: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
reversible: false
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
name: C-3 sterol keto reductase (zymosterol)

http://identifiers.org/biomodels.db/MODEL1310110003#_e663a8d7_1bee_4627_b239_43f81ad398fc
is encoded by: hsa:100287639
has only substance units: false
is: SBO:0000252
name: _100287639_1_c
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
boundary condition: true

metaM amp x
has only substance units: false
constant: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
type: Species
boundary condition: false
is: C00020
is: HMDB00045
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:456215
name: AMP

metaM pail345p hs c
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
initial amount: NaN
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
has only substance units: false
is: CHEBI:57836
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: SBO:0000247

metaR ALCD2yf
is: SBO:0000176
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (10327.1) or (10327.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:11003211,PMID:14576493,PMID:19382904,PMID:19382905 NOTES:NCD
reversible: false
fast: false
is described by: ECO:0000134
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
type: Reaction
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.1.2
reactant: MODEL1310110003#
product: MODEL1310110003#

metaM mag hs c
name: monoacylglycerol 2
type: Species
is: SBO:0000247
constant: false
is: HMDB12130
boundary condition: false
is: CHEBI:16987
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
initial amount: NaN

metaR DCTPtn
name: dCTP diffusion in nucleus
kinetic law: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110003#
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110003#

metaR r2361
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110003#
reversible: true
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaR r2088
product: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110003#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaM ksii core2 pre9 g
constant: false
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: keratan sulfate II biosynthesis, precursor 9
initial amount: NaN
is: CHEBI:28067

metaM hyptaur c
type: Species
initial amount: NaN
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:16668
is: HMDB00965
name: Hypotaurine

metaM glyald c
is: CHEBI:17378
name: D-Glyceraldehyde
boundary condition: false
has only substance units: false
is: HMDB01051
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
constant: false
is: C00577

metaR NDPK1n
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110003#
reversible: true
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
product: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000134
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR r2081
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaM gdpfuc c
type: Species
is: CHEBI:57984
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB01095
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
boundary condition: false
name: GDP-L-fucose(2-)

http://identifiers.org/biomodels.db/MODEL1310110003#_4fdb59ca_5b31_43f4_833c_3e8899a29a74
has only substance units: false
is encoded by: hsa:4758
constant: false
has part: Q99519
has part: P16278
name: GALNS:GLB1:NEU1:CTSA
boundary condition: true
initial amount: NaN
is encoded by: hsa:5476
is encoded by: hsa:2720
initial concentration: NaN
is: SBO:0000297
type: Species
is encoded by: hsa:2588
has part: P10619
has part: P34059

metaM acgam6p c
is: HMDB01062
initial amount: NaN
type: Species
is: SBO:0000247
name: N-acetyl-D-glucosamine 6-phosphate(2-)
constant: false
is: CHEBI:57513
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM ak2lgchol hs e
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
boundary condition: false
type: Species
constant: false
initial amount: NaN
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6975
is: C04317

metaM xol7aone r
has only substance units: false
is: CHEBI:17899
is: SBO:0000247
name: 7alpha-hydroxycholest-4-en-3-one
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01993
constant: false
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_ef40f76e_4dbf_4383_b05b_5416a419231b
initial amount: NaN
is: B4DYG5
has only substance units: false
type: Species
initial concentration: NaN
name: PI4KA
is encoded by: hsa:5297
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_02babbaa_c715_48dc_9e3b_3b2c07455fb3
constant: false
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:6568
initial concentration: NaN
boundary condition: true
name: SLC17A1
initial amount: NaN
is: Q14916

http://identifiers.org/biomodels.db/MODEL1310110003#_2dbeb52d_02bd_43d4_b62a_5c8369cc175e
boundary condition: true
is encoded by: hsa:85365
constant: false
type: Species
initial concentration: NaN
name: ALG2
is: Q9H553
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaR VALtec
reversible: true
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
modifier: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
name: L-valine transport via diffusion (extracellular to cytosol)
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110003#
fast: false
is described by: ECO:0000269

metaM glcur c
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: HMDB00127
initial concentration: 1.0
is: CHEBI:15748
has only substance units: false
is: SBO:0000247
name: D-glucuronate
type: Species
constant: false
boundary condition: false
initial amount: NaN

metaM 34dhoxmand m
initial concentration: 1.0
is: CHEBI:27637
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB01866
has only substance units: false
name: 3,4-Dihydroxymandelate
type: Species

metaM co2 r
initial concentration: 1.0
type: Species
is: HMDB01967
name: CO2
is: SBO:0000247
is: C00011
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: CHEBI:16526

metaR NDPK1m
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
kinetic law: MODEL1310110003#
reversible: true
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
is described by: ECO:0000254
reactant: MODEL1310110003#
is: SBO:0000176
fast: false
modifier: MODEL1310110003#
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_f61bc9f1_6f95_4016_84b5_7f1a867293aa
boundary condition: true
initial concentration: NaN
is encoded by: hsa:54344
is: SBO:0000252
type: Species
has only substance units: false
name: DPM3
initial amount: NaN
is: Q86TM7
constant: false

metaM arg L e
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
name: L-argininium(1+)
initial amount: NaN
is: HMDB00517
type: Species
initial concentration: 1.0
is: CHEBI:32682

metaR r2082
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110003#
fast: false

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaM gchola c
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58235
has only substance units: false
constant: false
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
initial amount: NaN
name: glycocholate
boundary condition: false
type: Species
is: HMDB00138

metaR PCt
reversible: true
modifier: MODEL1310110003#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110003#
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.6.3.44
name: phosphatidylcholine transporter
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
fast: false

metaR 34DHXMANDACOX NADP
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110003#
is described by: ECO:0000269
modifier: MODEL1310110003#
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase
notes: GENE_ASSOCIATION: (221.1) or (222.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10424772,PMID:12616643 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110003#_471f9a8b_2a1e_45a6_8557_566d65ee0667
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: NAGLU
is encoded by: hsa:4669
constant: false
is: SBO:0000252
has only substance units: false
is: P54802

http://identifiers.org/biomodels.db/MODEL1310110003#_9ab32d28_a914_4223_a580_9a82184fc89b
boundary condition: true
type: Species
is encoded by: hsa:10935
is: P30048
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: PRDX3

metaR AMY1e
type: Reaction
is: SBO:0000176
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.2.1.1
is described by: ECO:0000000
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (6520.1) or (280.1) or (278.1) or (276.1) or (277.1) or (6519.1 and 11136.1) or (276.2) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110003#
reversible: false
reactant: MODEL1310110003#
fast: false
name: alpha-amylase, extracellular (strch1 -> strch2)

metaM dcyt c
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: SBO:0000247
has only substance units: false
is: CHEBI:15698
type: Species
boundary condition: false
initial concentration: 1.0
name: Deoxycytidine
is: C00881
is: HMDB00014
constant: false
initial amount: NaN

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaR MI1345PP
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.86
is: SBO:0000176
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.56
reactant: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.36
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
product: MODEL1310110003#
reversible: false
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
fast: false

metaR PUNP7
name: purine-nucleoside phosphorylase (Xanthosine)
reactant: MODEL1310110003#
fast: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
is: SBO:0000176
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.2.1

metaR r0509
kinetic law: MODEL1310110003#
product: MODEL1310110003#
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110003#

metaM eandrstrn r
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C19H28O3 CHARGE: 0 INCHI: InChI=1S/C19H28O3/c1-18-7-5-12(20)9-11(18)3-4-13-14(18)6-8-19(2)15(13)10-16(21)17(19)22/h3,12-16,20-21H,4-10H2,1-2H3/t12-,13+,14-,15-,16+,18-,19-/m0/s1 EHMN_ABBREVIATION: C05139
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:27771
is: HMDB00352
boundary condition: false
name: 16alpha-hydroxydehydroepiandrosterone

metaM tcynt m
initial amount: NaN
is: SBO:0000247
constant: false
name: thiocyanate
initial concentration: 1.0
notes: FORMULA: CNS CHARGE: -1 INCHI: InChI=1S/CHNS/c2-1-3/h3H/p-1 EHMN_ABBREVIATION: C01755
has only substance units: false
is: HMDB01453
type: Species
boundary condition: false
is: CHEBI:18022

metaR r1977
kinetic law: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110003#
name: Y+LAT2 Utilized transport
product: MODEL1310110003#
fast: false
reactant: MODEL1310110003#

metaM idour e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/p-1/t2-,3+,4-,5+/m0/s1
name: L-iduronate
is: HMDB02704
initial concentration: 1.0
has only substance units: false
is: CHEBI:21338
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_dc4be77d_9787_40c2_a6da_4a0ac11e5995
is: SBO:0000252
type: Species
has only substance units: false
name: AK4
constant: false
is: P27144
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:205
boundary condition: true

metaR FAEL205
name: fatty-acyl-CoA elongation (n-C20:5CoA)
modifier: MODEL1310110003#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reversible: false
reactant: MODEL1310110003#
is: SBO:0000176

metaR r2083
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000185
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_da459a68_d9b4_41f9_9399_836e3e64ed47
name: PLCB4
initial amount: NaN
boundary condition: true
is encoded by: hsa:5332
initial concentration: NaN
is: Q15147
constant: false
is: SBO:0000252
type: Species
has only substance units: false

metaM HC00250 e
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
name: hydrosulfide
initial concentration: 1.0
has only substance units: false
is: CHEBI:29919
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_2eba1afc_bfa4_4e09_9e4c_1f0d70c3ebaa
has only substance units: false
initial concentration: NaN
is: B3KTQ4
name: B3GALNT1
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:8706
type: Species

metaM paps c
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
initial concentration: 1.0
boundary condition: false
is: CHEBI:58339
is: HMDB01134
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
has only substance units: false
type: Species
constant: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_220b277c_b8ed_4060_9de2_32b5a6755440
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:23007
is: Q4KWH8
type: Species
initial amount: NaN
name: PLCH1
initial concentration: NaN

metaR DGSNt
product: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
reversible: true
is: SBO:0000185
name: deoyguanosine transport via diffusion
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
reactant: MODEL1310110003#

metaM gthox m
boundary condition: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:58297
is: SBO:0000247
is: HMDB03337
constant: false

metaM ha l
initial amount: NaN
constant: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:16336
has only substance units: false
name: hyaluronan
type: Species

metaR S6T4g
is: SBO:0000176
kinetic law: MODEL1310110003#
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_a27b1461_d123_4232_9d35_d18c7e3bde35
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaM 4ppcys m
constant: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
type: Species
is: CHEBI:59458
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: HMDB01117

metaM pser L c
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C3H5NO6P CHARGE: -3 INCHI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00621
is: HMDB01721
initial amount: NaN
is: CHEBI:15811
is: SBO:0000247
boundary condition: false
has only substance units: false
name: O-Phospho-L-serine

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaM nrpphr e
type: Species
initial amount: NaN
is: CHEBI:33569
name: Norepinephrine
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB00216
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_04c4e30e_8b04_45fe_8353_646bb2300b6b
constant: false
type: Species
has only substance units: false
boundary condition: true
name: HK1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:3098
is: Q59FD4
is: SBO:0000252

metaM gchola e
initial amount: NaN
initial concentration: 1.0
type: Species
name: glycocholate
is: SBO:0000247
boundary condition: false
is: HMDB00138
constant: false
notes: FORMULA: C26H43NO6 CHARGE: 0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_7c43a962_2d8c_4e3c_afa0_481f7db8dbc8
is: SBO:0000252
is: P14618
initial amount: NaN
boundary condition: true
name: PKM2
has only substance units: false
constant: false
type: Species
is encoded by: hsa:5315
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_7a309e57_560b_4a4e_b18e_e350dfaa534f
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1350
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: COX7C
is: P15954

metaR r2084
reversible: true
reactant: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110003#

metaR DM ethamp r
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaM 10fthf6glu e
has only substance units: false
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
type: Species
is: SBO:0000247
constant: false
is: CHEBI:57454
is: HMDB00972
initial amount: NaN
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](6)
boundary condition: false

metaR PMEVKc
reactant: MODEL1310110003#
name: phosphomevalonate kinase, cytosol
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). Reactions till farnesyl pyrophosphate operates in cytosol, however, further steps including squalene synthase operates in E.R (Harpers illustrated Biochemistry (2009) 28th edition, Lange medical publications, chapter 26, page 224-227). all the cholesterol synthesis enzymes have also been found in peroxisomes (PMID: 12121718), no evidence for enterocyte sub-cellular sites, so cytosolic reactions have been added according to Harper book. one proton added to substrate for elemental balancing.
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.2
product: MODEL1310110003#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110003#_4fc6b621_8df9_4541_a361_19072a2d5c2c
constant: false
is: O75874
initial amount: NaN
has only substance units: false
name: IDH1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:3417

metaR r2439
name: Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP), TCDB:2.A.53.2.2
reversible: false
fast: false
is described by: ECO:0000000
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12759755 NOTES:
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
type: Reaction

metaM crn m
name: L-Carnitine
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00062
boundary condition: false
is: CHEBI:16347
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
is: C00318
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_f0a440cf_2a40_4f22_b7a4_b20d455f5d02
is encoded by: hsa:64078
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
name: SLC28A3
initial concentration: NaN
initial amount: NaN
is: Q9HAS3
constant: false

metaR DHPM2
reversible: false
type: Reaction
kinetic law: MODEL1310110003#
name: dihydropyrimidinase (dihydrothymine)
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110003#
product: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 2 AUTHORS: NOTES:Also acts on dihydrothymine and hydantoin. Found not specific evidence in PubMed, but Dihydropyrimidinase is supposed to be in cytosol and catalyze this reaction. Old information

metaR NDPK9n
fast: false
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
type: Reaction
is: SBO:0000176
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110003#
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
kinetic law: MODEL1310110003#

metaM dcyt e
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: CHEBI:15698
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
name: Deoxycytidine
is: C00881
is: HMDB00014
constant: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_bf2e398e_df5b_4804_8573_13d9b3212f88
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:1892
name: ECHS1
is: P30084
is: SBO:0000252
type: Species
initial concentration: NaN

metaR DESAT20 2
fast: false
modifier: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
is described by: ECO:0000000
name: fatty acyl-CoA desaturase (n-C20:4CoA -> n-C20:5CoA)
kinetic law: MODEL1310110003#
reversible: false
product: MODEL1310110003#
is: SBO:0000176

metaM co2 m
has only substance units: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
boundary condition: false
is: C00011
is: HMDB01967
is: SBO:0000247
name: CO2
is: CHEBI:16526
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_4c0be9b0_0c01_4143_8e53_baa9dd2eb2bf
name: CDS1
initial concentration: NaN
is encoded by: hsa:1040
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q92903
type: Species

metaM pglyc hs c
name: pglyc_hs[c]
has only substance units: false
notes: FORMULA: CHARGE: 0
is: HMDB02704
initial amount: NaN
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:21338
is: SBO:0000247
boundary condition: false

metaR r2002
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
is: SBO:0000185
fast: false
modifier: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_bd829e24_23b5_49e5_9861_67342ed85227
is: O43181
is: SBO:0000252
name: NDUFS4
is encoded by: hsa:4724
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

metaR UMPK2
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false
type: Reaction
modifier: MODEL1310110003#
reversible: true
name: UMP kinase (CTP)
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14

http://identifiers.org/biomodels.db/MODEL1310110003#_cd29c22b_a138_49c6_9846_fe244780fc54
boundary condition: true
constant: false
is: P49902
initial amount: NaN
has only substance units: false
type: Species
name: NT5C2
is encoded by: hsa:22978
initial concentration: NaN
is: SBO:0000252

metaR GLCAASE9ly
reversible: false
is: SBO:0000176
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110003#
name: beta-glucuronidase, lysosomal
type: Reaction
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110003#_a33eda2f_b8bd_4501_a057_1c7fc2e03e6f
constant: false
is: P09417
has only substance units: false
initial concentration: NaN
boundary condition: true
name: QDPR
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5860

http://identifiers.org/biomodels.db/MODEL1310110003#_962c8ca6_9903_4758_8531_d3f81247aef3
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:AW299740
initial concentration: NaN
name: _AW299740_1_m
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_52b78647_89d5_4b3c_8204_4707b0b55406
is: Q9GZX3
type: Species
name: CHST6
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:4166

http://identifiers.org/biomodels.db/MODEL1310110003#_63da26e5_12ca_4a53_a787_7fed1ac47bac
type: Species
is: P40926
initial amount: NaN
constant: false
is: SBO:0000252
name: MDH2
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:4191

http://identifiers.org/biomodels.db/MODEL1310110003#_94c94433_b3aa_4158_8775_525a5026f978
initial concentration: NaN
has part: O95498
is: SBO:0000297
is encoded by: hsa:55350
initial amount: NaN
name: VNN3:VNN2:VNN1
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:8875
type: Species

metaM ipdp c
is: HMDB01347
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:128769
is: C00129
name: Isopentenyl diphosphate
initial amount: NaN
notes: FORMULA: C5H9O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
constant: false
is: SBO:0000247

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_390d06c2_c8cc_45ab_a434_5d08e247d780
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI480132
type: Species
name: _AI480132_1_c
constant: false
initial amount: NaN

metaM HC00250 c
constant: false
is: CHEBI:29919
name: hydrosulfide
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_b4d6658d_2de7_4103_931b_9fab2fff55bb
is encoded by: hsa:10948
name: STARD3
type: Species
initial amount: NaN
has only substance units: false
is: B4DUY1
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR UMPK3
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reversible: true
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (UTP)

metaR r0627
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:
fast: false
is described by: ECO:0000000
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
is: SBO:0000176
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#

metaM dhdascb e
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
is: CHEBI:58070
name: dehydroascorbide(1-)
type: Species
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: HMDB01264
initial concentration: 1.0
has only substance units: false

metaR MMCDm
is: SBO:0000176
is described by: ECO:0000212
reactant: MODEL1310110003#
name: Methylmalonyl-CoA decarboxylase, mitochondrial
modifier: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.9

metaM 3hbcoa m
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
initial amount: NaN
is: HMDB01166
type: Species
is: CHEBI:57316
has only substance units: false
name: (S)-3-hydroxybutanoyl-CoA(4-)
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false

metaM amp r
is: HMDB00045
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
is: CHEBI:456215
name: AMP
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: C00020
has only substance units: false
type: Species
initial concentration: 1.0

metaM core6 g
constant: false
type: Species
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false
name: Core 6
initial amount: NaN
is: C04383

metaR MMTSADm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
type: Reaction
kinetic law: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#
reactant: MODEL1310110003#
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
reversible: false
is described by: ECO:0000000

metaM nrpphr c
boundary condition: false
initial concentration: 1.0
is: CHEBI:33569
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
has only substance units: false
initial amount: NaN
is: HMDB00216
type: Species
name: Norepinephrine
is: SBO:0000247
constant: false

metaM cmp n
name: CMP(2-)
is: SBO:0000247
is: HMDB00095
type: Species
constant: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:60377

metaR ARACHDt2
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
type: Reaction
product: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110003#
fast: false
name: fatty acid transport via diffusion

http://identifiers.org/biomodels.db/MODEL1310110003#_a46e1b86_c23e_427b_9c6b_da84117ab8f6
is: Q16718
constant: false
initial concentration: NaN
is encoded by: hsa:4698
type: Species
is: SBO:0000252
name: NDUFA5
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_5e990233_bb80_4cbb_8dbb_2cabea6d90c3
constant: false
is encoded by: hsa:412
is: SBO:0000252
type: Species
boundary condition: true
is: P08842
name: STS
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_2b0db7ce_d64e_4138_b8a0_0afb56b0f101
boundary condition: true
name: SLC6A14
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
is: Q9UN76
is: SBO:0000252
is encoded by: hsa:11254
type: Species

metaR r1260
reversible: false
reactant: MODEL1310110003#
name: EC:6.2.1.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#

metaR FATP3t
reversible: true
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000269
name: fatty acid electroneutral transport
product: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is: SBO:0000185
type: Reaction
fast: false

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_abb872e6_7824_450f_8d2f_c7d589b1b1ca
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
name: SLC7A10
is encoded by: hsa:56301
is: Q9NS82
constant: false
boundary condition: true
has only substance units: false

metaR SUCCTD
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaR FTCD
product: MODEL1310110003#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.1.2.5
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Folate metabolism EC Number: 4.3.1.4 Confidence Level: 4 AUTHORS: PMID:14697341 NOTES:IT
name: formimidoyltransferase cyclodeaminase
reversible: false
type: Reaction
kinetic law: MODEL1310110003#
fast: false

metaM ksii core2 pre2 g
name: keratan sulfate II biosynthesis, precursor 2
has only substance units: false
constant: false
notes: FORMULA: C39H63N3O28X CHARGE: -1
boundary condition: false
is: CHEBI:58053
is: C00130
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00175
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_42ee6fbd_7ab7_4391_8c49_42ec09829a8f
is: SBO:0000252
is encoded by: hsa:51095
initial amount: NaN
boundary condition: true
name: TRNT1
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: Q96Q11

metaM 3mox4hoxm c
type: Species
is: CHEBI:27622
is: SBO:0000247
constant: false
is: HMDB00291
initial amount: NaN
name: 3-Methoxy-4-hydroxymandelate
boundary condition: false
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
has only substance units: false
initial concentration: 1.0

metaR UMPK4
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
product: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
is described by: ECO:0000269
modifier: MODEL1310110003#
name: UMP kinase (GTP)
type: Reaction

metaR r2368
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110003#
type: Reaction
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_ce03d616_8070_4af3_9ddc_b0c9c63b896a
initial amount: NaN
name: CA14
is: A8K3J4
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:23632
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_3032373c_80e4_4696_b3b2_74d7ac5217bb
is encoded by: hsa:AA081045
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: _AA081045_1_m

http://identifiers.org/biomodels.db/MODEL1310110003#_9f8868e5_66de_4f9c_84d5_e51884bdfff1
has only substance units: false
name: CHST1
type: Species
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is: O43916
is encoded by: hsa:8534
initial concentration: NaN

metaM HC00319 m
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:30794
name: Malonate
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial amount: NaN

metaR ADPtx
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
product: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
name: ADP transporter, peroxisomal
is: SBO:0000185

metaM 5dhf e
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
is: SBO:0000247
name: pentaglutamyl folate (DHF)
initial amount: NaN
constant: false
has only substance units: false
is: HMDB06487
type: Species
initial concentration: 1.0
boundary condition: false

metaM 5aop m
initial amount: NaN
is: SBO:0000247
is: C00430
name: 5-Amino-4-oxopentanoate
constant: false
boundary condition: false
is: HMDB01149
is: CHEBI:17549
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_233d4cc9_26b6_4bae_b433_4b1f0e164947
has only substance units: false
name: HSD3B1
is: P14060
initial concentration: NaN
is encoded by: hsa:3283
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR LNLCCPT2
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
product: MODEL1310110003#
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110003#

metaR LNLNCAt
is: SBO:0000185
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion

metaM HC01111 c
type: Species
name: Galactose-1P
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3+,4+,5-,6?/m1/s1
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: CHEBI:37480

metaM 44mzym r
boundary condition: false
name: 14-demethyllanosterol
initial amount: NaN
is: CHEBI:18364
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01286
type: Species
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108

metaM malcoa r
name: malonyl-CoA(4-)
constant: false
is: HMDB01175
has only substance units: false
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
initial concentration: 1.0
boundary condition: false
is: CHEBI:57384
type: Species
is: SBO:0000247
initial amount: NaN

metaR EX creat LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Creatine exchange
type: Reaction

metaM mi13p c
boundary condition: false
initial concentration: 1.0
name: 1D-myo-Inositol 1,3-bisphosphate
is: HMDB06234
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: CHEBI:18225
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
initial amount: NaN

metaR PRAGSr
is version of: http://identifiers.org/ec-code/2.1.2.2
product: MODEL1310110003#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110003#
fast: false
name: phosphoribosylglycinamide synthase
type: Reaction
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM T antigen g
name: T antigen (core 1)
type: Species
notes: FORMULA: C14H24NO10X CHARGE: 0
is: SBO:0000247
is: CHEBI:22783
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

metaR 5ADTSTSTERONESte
kinetic law: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
is: SBO:0000185
fast: false
type: Reaction
name: sulfonated testosterone transport
product: MODEL1310110003#
is described by: ECO:0000000

metaR ICDHy
reversible: false
name: isocitrate dehydrogenase (NADP)
is version of: http://identifiers.org/ec-code/1.1.1.42
is described by: ECO:0000269
fast: false
modifier: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176

metaR r0629
product: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.4.1
is described by: ECO:0000000
fast: false
modifier: MODEL1310110003#
is: SBO:0000176
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.6.1.22
type: Reaction
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65

metaR DESAT20 1
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
reversible: false
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
product: MODEL1310110003#

metaM cdpdag hs c
is: SBO:0000247
is: CHEBI:58332
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
type: Species
name: CDP-diacylglycerol(2-)
initial amount: NaN
initial concentration: 1.0

metaR r2080
fast: false
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
product: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110003#

metaR UMPK5
type: Reaction
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110003#
product: MODEL1310110003#
name: UMP kinase (dATP)
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR r2369
product: MODEL1310110003#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110003#
fast: false
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110003#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR GNDer
reversible: false
kinetic law: MODEL1310110003#
is: SBO:0000176
reactant: MODEL1310110003#
fast: false
is described by: ECO:0000000
name: phosphogluconate dehydrogenase, endoplasmic reticulum
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_9943fca5_5473_4df4_a7cd_1cc4fdb7ff44
type: Species
name: CHAT
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:1103
is: SBO:0000252
is: Q6LEN5

metaM arg L c
constant: false
is: HMDB00517
name: L-argininium(1+)
boundary condition: false
is: CHEBI:32682
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN

metaR G14T9g
fast: false
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
product: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176

metaM ksi pre20 g
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:28067
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
is: SBO:0000247
has only substance units: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 20
type: Species

metaR LNLCCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110003#
reactant: MODEL1310110003#
name: carnitine O-palmitoyltransferase
type: Reaction
product: MODEL1310110003#
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110003#

metaM betald m
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
has only substance units: false
constant: false
initial amount: NaN
name: betaine aldehyde
type: Species
is: HMDB01252
is: SBO:0000247
is: CHEBI:15710

http://identifiers.org/biomodels.db/MODEL1310110003#_3d3cacee_64d0_4736_aea7_56c34c2e1f18
has only substance units: false
is encoded by: hsa:4712
is: Q5VYT2
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: NDUFB6

http://identifiers.org/biomodels.db/MODEL1310110003#_64f98119_4ecb_43c9_b78c_e596edaaf000
type: Species
is encoded by: hsa:4710
name: NDUFB4
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
is: SBO:0000252
is: O95168

metaM ksi pre4 g
is: SBO:0000247
notes: FORMULA: C101H165N7O72X CHARGE: -1
boundary condition: false
type: Species
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 4
is: CHEBI:58053
initial amount: NaN
constant: false
has only substance units: false
is: C00130
initial concentration: 1.0

metaM CE5121 m
is: CHEBI:57449
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: trans-3-decenoyl-CoA
is: SBO:0000247
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM dump c
is: SBO:0000247
has only substance units: false
is: HMDB01409
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
is: C00365
is: CHEBI:246422
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: dUMP
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_34518641_1ffc_4fa1_9ced_6e4603e46d0a
is encoded by: hsa:347734
initial amount: NaN
initial concentration: NaN
is: Q8TB61
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: SLC35B2
boundary condition: true

metaR r0377
modifier: MODEL1310110003#
product: MODEL1310110003#
reversible: false
reactant: MODEL1310110003#
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.4.3
is: SBO:0000176
kinetic law: MODEL1310110003#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_18737401_c37c_4a30_8d4b_f39d4a0a8b84
is encoded by: hsa:586
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: P54687
name: BCAT1
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_63977ff4_facb_4eb2_83ab_d1d41965aff3
is encoded by: hsa:8034
is: SBO:0000252
boundary condition: true
name: SLC25A16
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: P16260

http://identifiers.org/biomodels.db/MODEL1310110003#_26a13f68_7cfb_45cd_8228_50050a7821eb
is: Q6P4B4
initial concentration: NaN
name: PFAS
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:5198
has only substance units: false
constant: false
is: SBO:0000252

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR RE3242R
type: Reaction
reactant: MODEL1310110003#
fast: false
reversible: true
kinetic law: MODEL1310110003#
name: RE3242
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
modifier: MODEL1310110003#

metaM ptth m
is: HMDB03426
name: pantetheine
boundary condition: false
type: Species
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:16753

metaM ppcoa x
initial concentration: 1.0
is: CHEBI:57392
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: HMDB01275
is: SBO:0000247
name: Propanoyl-CoA
initial amount: NaN
has only substance units: false
boundary condition: false
is: C00100
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_a1ddcb54_d129_4a3b_a810_92e7987ff200
boundary condition: true
is: O95139
is encoded by: hsa:4712
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: NDUFB6
has only substance units: false

metaR RDH2a
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.300
is: SBO:0000176
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
name: retinol dehydrogenase (9-cis,NADPH)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.105
reversible: true
kinetic law: MODEL1310110003#
fast: false
modifier: MODEL1310110003#

metaR r1633
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110003#
fast: false
product: MODEL1310110003#
is: SBO:0000185

metaM 56dura c
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:15901
initial concentration: 1.0
constant: false
is: HMDB00076
name: 5,6-dihydrouracil
is: SBO:0000247

metaR G14T12g
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
reversible: false

metaM cysam c
is: CHEBI:58029
boundary condition: false
name: cysteaminium
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
constant: false
is: HMDB02991

metaM leuktrF4 c
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
initial concentration: 1.0
name: leukotriene F4
boundary condition: false
constant: false
is: HMDB06465
is: CHEBI:27491

metaM mal L m
is: CHEBI:15589
is: SBO:0000247
initial amount: NaN
name: (S)-malate(2-)
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial concentration: 1.0
constant: false
is: HMDB00156
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_519a7e69_efc2_490f_8ceb_2e7012d1c706
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: SLC27A1
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:376497
is: Q6PCB7

metaR EX dgsn LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyguanosine
type: Reaction

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_180c37b7_ea21_4b58_b48d_d6f566a3e6b9
is encoded by: hsa:9057
initial amount: NaN
is: SBO:0000297
has part: Q92536
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
name: SLC3A2:SLC7A6
type: Species

metaR r2443
reactant: MODEL1310110003#
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
fast: false
reversible: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110003#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_e467062b_bcb4_45dc_90e5_fe7a8a07bb41
is encoded by: hsa:11253
name: MAN1B1
is: SBO:0000252
is: Q9UKM7
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_f3b45331_0e6a_46ce_af04_6cb3484a7f2b
is: SBO:0000252
is: P47989
boundary condition: true
name: XDH
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:7498
initial amount: NaN
constant: false

metaM dolp U c
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
is: SBO:0000247
constant: false
initial concentration: 1.0
name: dolichyl phosphate(2-)

metaR ARACHCPT2
fast: false
product: MODEL1310110003#
is described by: ECO:0000000
name: carnitine transferase
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110003#
reversible: false
is: SBO:0000176
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_08464c99_ad13_492a_85c5_f4872798a7bb
initial amount: NaN
boundary condition: true
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:1593
is: Q02318
name: CYP27A1
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_21d3be2b_cd6d_420c_94be_2901023b7fc2
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
name: _AI924226_1_m
is encoded by: hsa:AI924226
has only substance units: false
initial concentration: NaN

metaM Rtotal2coa c
boundary condition: false
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:60377
notes: FORMULA: CO2FULLR2C21H31N7O15P3S CHARGE: -4
is: HMDB00095
is: C00055
initial concentration: 1.0
name: R total 2 coenzyme A
is: SBO:0000247

metaM gullac r
is: CHEBI:17587
name: L-gulono-1,4-lactone
initial concentration: 1.0
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
type: Species
is: HMDB03466
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_d5f2ce1c_ad70_4826_856f_c9d9daa9d14b
is encoded by: hsa:5106
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
name: PCK2
boundary condition: true
is: Q16822
constant: false

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR GLCURtly
name: glucuronate transport into lysososme
kinetic law: MODEL1310110003#
fast: false
reversible: true
modifier: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD

metaM ump r
type: Species
name: UMP
initial amount: NaN
is: SBO:0000247
is: CHEBI:57865
boundary condition: false
is: HMDB00288
has only substance units: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial concentration: 1.0
constant: false

metaR r1634
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110003#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110003#

metaR ARGtm
reversible: true
kinetic law: MODEL1310110003#
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
name: arginine mitochondrial transport via ornithine carrier
fast: false
modifier: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
type: Reaction

metaM 34dhoxmand c
type: Species
is: CHEBI:27637
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
has only substance units: false
is: HMDB01866
constant: false
name: 3,4-Dihydroxymandelate
initial amount: NaN
boundary condition: false

metaM ksi pre16 g
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 16
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
is: C00130
type: Species
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
is: HMDB00175
is: CHEBI:58053

metaM tststerone c
constant: false
type: Species
boundary condition: false
initial amount: NaN
name: testosterone
is: HMDB00234
initial concentration: 1.0
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: SBO:0000247
has only substance units: false
is: CHEBI:17347

http://identifiers.org/biomodels.db/MODEL1310110003#_01c9b706_f792_486d_a032_5f0718e5c90f
is: SBO:0000252
name: _AV713053_1_m
has only substance units: false
is encoded by: hsa:AV713053
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
boundary condition: true

metaR TPI
fast: false
reactant: MODEL1310110003#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110003#
reversible: true
is described by: ECO:0000134
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
is version of: http://identifiers.org/ec-code/5.3.1.1
kinetic law: MODEL1310110003#
name: triose-phosphate isomerase

metaM ksii core2 pre7 g
type: Species
name: keratan sulfate II biosynthesis, precursor 7
is: C00130
is: CHEBI:58053
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C67H108N5O51SX CHARGE: -2
is: HMDB00175
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false

metaM mn l
name: beta-1,4-mannose-N-acetylglucosamine
is: HMDB06535
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_5a352a94_ddaa_4052_8049_d6fa6aa21354
initial concentration: NaN
is: Q7GXZ8
is encoded by: hsa:4513
initial amount: NaN
is: SBO:0000252
name: COX2
boundary condition: true
has only substance units: false
constant: false
type: Species

metaM na1 r
is: CHEBI:29101
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
is: HMDB00588
boundary condition: false
constant: false
initial amount: NaN
type: Species
name: sodium(1+)
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_7de6c902_c81d_4489_9700_fb02d0eff100
has only substance units: false
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:594
constant: false
name: DBT:DLD:BCKDHA:BCKDHB
has part: Q9BQL0
initial concentration: NaN
type: Species
boundary condition: true

metaR r1631
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110003#
reversible: true
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false
type: Reaction

metaM prostgd2 r
is: HMDB01403
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
initial concentration: 1.0
is: CHEBI:57406
type: Species
constant: false
name: prostaglandin D2(1-)
has only substance units: false
is: SBO:0000247

metaR EX tag hs LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: triacylglycerol (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_1b72feb4_bc0e_46c1_9adb_dca66d35d50c
is encoded by: hsa:285973
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is: Q674R7
name: ATG9B
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_743a6a4c_23bf_4018_8348_e25d1c79f40f
has only substance units: false
is encoded by: hsa:377841
boundary condition: true
type: Species
is: Q5MY95
initial amount: NaN
initial concentration: NaN
name: ENTPD8
is: SBO:0000252
constant: false

metaR DRPA
type: Reaction
fast: false
name: deoxyribose-phosphate aldolase
is described by: ECO:0000000
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is: SBO:0000176
reactant: MODEL1310110003#
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_6c411752_941e_47f5_8699_9552df98a8eb
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:9061
type: Species
name: PAPSS1
boundary condition: true
initial concentration: NaN
is: O43252

metaR HGNTOR
fast: false
type: Reaction
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.13.11.5
reversible: false
modifier: MODEL1310110003#
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110003#
is described by: ECO:0000269
product: MODEL1310110003#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_36fa5ff7_3386_499d_9975_10e65c12834b
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q6IBC4
has only substance units: false
is encoded by: hsa:4726
name: NDUFS6
constant: false

metaM Ser Gly Ala X Gly l
is: CHEBI:16347
boundary condition: false
is: HMDB00062
constant: false
notes: FORMULA: XH CHARGE: 0
type: Species
is: SBO:0000247
is: C00318
initial concentration: 1.0
has only substance units: false
name: protein-linked serine residue (glycosaminoglycan attachment site)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_122a6acf_3f84_4ed8_b27f_fbe7ee23dc7e
initial amount: NaN
constant: false
is encoded by: hsa:1737
is: SBO:0000252
type: Species
is: Q86YI5
boundary condition: true
name: DLAT
has only substance units: false
initial concentration: NaN

metaM bilirub r
initial amount: NaN
type: Species
is: HMDB00054
constant: false
is: CHEBI:57977
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
is: SBO:0000247
boundary condition: false
name: bilirubin(2-)

metaR r0647
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
is: SBO:0000176
name: Spontaneous reaction
type: Reaction
fast: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
reversible: true

metaM nm4masn g
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C54H90N3O40X CHARGE: 0
initial amount: NaN
type: Species
is: C05882
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: SBO:0000247
constant: false

metaR APAT2rm
is described by: ECO:0000212
type: Reaction
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
fast: false
product: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.6.1.19
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
modifier: MODEL1310110003#

metaM HC02193 e
constant: false
name: glycolithocholate
type: Species
has only substance units: false
is: CHEBI:60008
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C26H42NO4 CHARGE: -1 INCHI: InChI=1S/C26H43NO4/c1-16(4-9-23(29)27-15-24(30)31)20-7-8-21-19-6-5-17-14-18(28)10-12-25(17,2)22(19)11-13-26(20,21)3/h16-22,28H,4-15H2,1-3H3,(H,27,29)(H,30,31)/p-1/t16-,17-,18-,19+,20-,21+,22+,25+,26-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110003#_d14e068f_068a_49fe_bcfb_8ba9511d9a7b
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:8612
constant: false
is: E9PAY8
name: PPAP2C

metaR LEUTA
name: leucine transaminase
type: Reaction
is described by: ECO:0000269
fast: false
reversible: true
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.6.1.42
is: SBO:0000176
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_94c54549_777c_4b12_9af8_3c3a98346821
initial concentration: NaN
is encoded by: hsa:2629
is: P04062
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
name: GBA
boundary condition: true

metaR CLPNDCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
name: fatty acid intracellular transport
reversible: true
type: Reaction
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110003#

metaR r0580
kinetic law: MODEL1310110003#
is: SBO:0000176
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
is described by: ECO:0000000
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.7
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
modifier: MODEL1310110003#

metaR r1632
modifier: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110003#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110003#
reversible: true
is: SBO:0000185
reactant: MODEL1310110003#
type: Reaction

metaM msa m
name: 3-oxopropanoate
constant: false
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:33190
initial concentration: 1.0
is: HMDB11111
is: SBO:0000247

metaR OCDCEAtr
is described by: ECO:0000000
reactant: MODEL1310110003#
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
type: Reaction
is: SBO:0000185
fast: false

metaM dag hs n
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:18035
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02055
name: diglyceride

metaR CYTK3n
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
name: cytidylate kinase (dCMP,CTP),nuclear
modifier: MODEL1310110003#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true

metaR EX pheacgln LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-N-Phenylacetyl-L-glutamine exchange
type: Reaction

metaM no c
is: C00533
name: Nitric oxide
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
is: CHEBI:16480
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB03378
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_5c037855_0a10_47e7_9801_cbc8d7e1b4c3
name: _AU149534_1_m
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:AU149534
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252

metaR r1745
is described by: ECO:0000000
reactant: MODEL1310110003#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: false
product: MODEL1310110003#

metaR MI1PS
fast: false
is described by: ECO:0000269
is: SBO:0000176
name: myo-Inositol-1-phosphate synthase
product: MODEL1310110003#
reversible: false
notes: GENE_ASSOCIATION: (51477.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 5.5.1.4 Confidence Level: 4 AUTHORS: PMID:12941308 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/5.5.1.4
modifier: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#

metaR MI145PK
reversible: false
fast: false
is described by: ECO:0000269
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.1.127
is: SBO:0000176
name: inositol-1,4,5-trisphosphate 3-kinase
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction

metaM xtsn c
boundary condition: false
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
is: SBO:0000247
is: HMDB00299
constant: false
initial amount: NaN
is: CHEBI:18107
type: Species
has only substance units: false
initial concentration: 1.0
name: xanthosine

metaM tststerone e
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: testosterone
is: CHEBI:17347
initial concentration: 1.0
is: HMDB00234

metaM hs deg24 l
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:16126
constant: false
notes: FORMULA: C31H50NO26 CHARGE: -1
type: Species
name: GlcNAc-GlcA-(Gal)2-Xyl

metaM amp m
boundary condition: false
type: Species
is: CHEBI:456215
is: HMDB00045
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial concentration: 1.0
constant: false
name: AMP(2-)

http://identifiers.org/biomodels.db/MODEL1310110003#_04cf38ce_6bb3_4878_8e0b_66ce7fd230d6
constant: false
is encoded by: hsa:R39999
has only substance units: false
name: _R39999_1_c
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_28085225_ce7f_4d67_8f7d_02c1a54c2f24
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
name: _AU149534_1_e
constant: false
is encoded by: hsa:AU149534
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_6865ce96_22ef_4937_a0cb_4c53951443ea
initial concentration: NaN
constant: false
is: Q15392
boundary condition: true
type: Species
is: SBO:0000252
name: DHCR24
has only substance units: false
initial amount: NaN
is encoded by: hsa:1718

metaM gly c
is: CHEBI:3339
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00123
is: C00037
initial amount: NaN
boundary condition: false
name: Glycine
is: SBO:0000247
constant: false
notes: FORMULA: C2H5NO2 CHARGE: 0

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_9df6c4e8_c810_4a39_b34d_a19b8ea2bf83
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

metaR MI145PP
is version of: http://identifiers.org/ec-code/3.1.3.56
reactant: MODEL1310110003#
fast: false
name: inositol-1,4,5-trisphosphate 5-phosphatase
is: SBO:0000176
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.36
is version of: http://identifiers.org/ec-code/3.1.3.86
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_dd2a0488_8e02_40ff_8160_0cd4af79d6fe
name: NDUFA13
is: SBO:0000252
type: Species
is: Q9P0J0
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:51079

http://identifiers.org/biomodels.db/MODEL1310110003#_60f2e6f0_5249_4194_90a5_0e06106fa161
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: _AA081045_1_e
is encoded by: hsa:AA081045
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaM glyc3p x
name: Glycerol 3-phosphate
is: HMDB00126
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
type: Species
is: C00093
is: CHEBI:57597
initial amount: NaN
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false

metaR biomass reaction
name: biomass_reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
reactant: MODEL1310110003#
product: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
reversible: false
type: Reaction
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110003#_a0f3836e_93b8_4dde_bd09_25461deef04b
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is: Q9BY07
initial concentration: NaN
is encoded by: hsa:57835
name: SLC4A5
boundary condition: true
type: Species

metaM HC02193 c
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:60008
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C26H42NO4 CHARGE: -1 INCHI: InChI=1S/C26H43NO4/c1-16(4-9-23(29)27-15-24(30)31)20-7-8-21-19-6-5-17-14-18(28)10-12-25(17,2)22(19)11-13-26(20,21)3/h16-22,28H,4-15H2,1-3H3,(H,27,29)(H,30,31)/p-1/t16-,17-,18-,19+,20-,21+,22+,25+,26-/m1/s1
name: glycolithocholate

http://identifiers.org/biomodels.db/MODEL1310110003#_051e07ec_0a0b_4039_8536_6254ab4ada64
type: Species
name: PANK4
boundary condition: true
has only substance units: false
is encoded by: hsa:55229
initial concentration: NaN
is: SBO:0000252
is: Q9NVE7
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_02245128_4e6c_43c2_ab79_1876a933b2c7
is: SBO:0000252
initial concentration: NaN
name: B4GALT2
type: Species
has only substance units: false
is encoded by: hsa:8704
initial amount: NaN
constant: false
boundary condition: true
is: O60909

metaM HC02204 c
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
name: prostaglandin-b1
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: CHEBI:27624

metaM ipdp x
name: isopentenyl diphosphate(3-)
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h1,3-4H2,2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00127 EHMN_ABBREVIATION: C00129
has only substance units: false
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB01347
is: CHEBI:128769

metaR r0504
modifier: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
type: Reaction
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.3.10
kinetic law: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:

metaR M1316Mg
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
kinetic law: MODEL1310110003#
type: Reaction
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.114
product: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_4a80cb33_4ba7_4734_9e60_e6266b5ef59d
boundary condition: true
has only substance units: false
name: AK4
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:205
constant: false
type: Species

metaM ump n
type: Species
name: UMP(2-)
is: CHEBI:57865
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: HMDB00288
has only substance units: false
constant: false
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_b4d2618e_7fa5_439b_8ff6_00fb5bd1658a
type: Species
is: SBO:0000252
name: _AL050025_1_c
is encoded by: hsa:AL050025
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM pail4p hs n
initial concentration: 1.0
has only substance units: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial amount: NaN
constant: false
is: CHEBI:58178
is: SBO:0000247
boundary condition: false

metaR r1630
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110003#
is described by: ECO:0000000
kinetic law: MODEL1310110003#
fast: false
reversible: true
reactant: MODEL1310110003#
is: SBO:0000185
type: Reaction

metaM C05957 r
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-13+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05957
type: Species
is: HMDB02710
has only substance units: false
name: Prostaglandin J2
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:27485
constant: false

metaR RE2269E
is version of: http://identifiers.org/ec-code/3.4.21.39
fast: false
name: RE2269
modifier: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
product: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#
reversible: true

metaM HC02210 c
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
is: CHEBI:34939
constant: false
name: prostaglandin-d3
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM creat e
initial concentration: 1.0
is: CHEBI:16919
is: HMDB00064
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
constant: false
name: creatine
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_2b3a4ed5_85bc_452b_85e2_1f9790170fe2
boundary condition: true
is encoded by: hsa:6307
is: A8MYF6
constant: false
is: SBO:0000252
initial amount: NaN
name: MSMO1
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_1e5d3be8_d73f_474c_ba09_3bd465c3765b
type: Species
constant: false
initial amount: NaN
is: O15056
initial concentration: NaN
boundary condition: true
name: SYNJ2
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8871

metaM tsul e
initial amount: NaN
type: Species
is: HMDB00257
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:16094
name: thiosulfate(2-)
constant: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
has only substance units: false

metaM prpp e
has only substance units: false
boundary condition: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
initial amount: NaN
is: CHEBI:58017
initial concentration: 1.0
constant: false
is: HMDB00280
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
is: SBO:0000247
type: Species

metaR IDOURtly
type: Reaction
modifier: MODEL1310110003#
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#
name: iduronate transport into lysososme
kinetic law: MODEL1310110003#
is: SBO:0000185
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD

http://identifiers.org/biomodels.db/MODEL1310110003#_7e960a86_e71e_41f1_ac4c_371c74d27da0
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:144195
boundary condition: true
name: SLC2A14
constant: false
is: Q8TDB8
initial concentration: NaN
initial amount: NaN

metaM pan4p e
is: CHEBI:47942
is: HMDB01416
is: SBO:0000247
constant: false
initial amount: NaN
name: Pantetheine 4'-phosphate
boundary condition: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2
has only substance units: false
is: C01134
type: Species
initial concentration: 1.0

metaR r0915
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110003#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
is described by: ECO:0000000

metaR XOL7AH2tm
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110003#
is described by: ECO:0000000

metaM no e
is: C00533
name: Nitric oxide
is: CHEBI:16480
constant: false
notes: FORMULA: NO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00415 EHMN_ABBREVIATION: C00533
initial concentration: 1.0
is: HMDB03378
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_93c82581_2d35_4c26_a06a_a6634bb35556
name: RDH16
is encoded by: hsa:8608
boundary condition: true
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is: O75452
initial amount: NaN
initial concentration: NaN

metaR MI1PP
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.25
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
modifier: MODEL1310110003#
fast: false
type: Reaction
name: myo-inositol 1-phosphatase

http://identifiers.org/biomodels.db/MODEL1310110003#_0794abb1_1df1_43f1_8fe1_146ac76d6952
initial amount: NaN
is encoded by: hsa:3036
constant: false
is: SBO:0000252
is: Q8IYH3
boundary condition: true
initial concentration: NaN
type: Species
name: HAS1
has only substance units: false

metaR r0796
kinetic law: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
type: Reaction
reactant: MODEL1310110003#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
is described by: ECO:0000000
modifier: MODEL1310110003#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
fast: false

metaR TYRCBOX
is: SBO:0000176
product: MODEL1310110003#
is described by: ECO:0000134
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.28
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
type: Reaction
reactant: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
name: L-Tyrosine carboxy-lyase
modifier: MODEL1310110003#

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaR 3HLYTCL
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/4.1.1.28
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110003#
name: 3-Hydroxy-L-tyrosine carboxy-lyase

http://identifiers.org/biomodels.db/MODEL1310110003#_61a89485_3ae6_4420_8c50_2b03f3f870cf
is: SBO:0000252
initial amount: NaN
is: Q96AT9
constant: false
name: RPE
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:6120

metaM gly e
constant: false
boundary condition: false
is: HMDB00123
is: C00037
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0
type: Species
name: Glycine
is: CHEBI:3339
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_77dd2d0d_2b4a_4c8a_aa03_3bea0c594768
is: Q9UFY1
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
name: PLCG1
is encoded by: hsa:5335
initial concentration: NaN
has only substance units: false
type: Species

metaM hs deg13 l
name: heparan sulfate, degradation product 13
type: Species
is: HMDB00719
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:15699
constant: false
notes: FORMULA: C55H83N3O61S5 CHARGE: -6
initial amount: NaN

metaR FACOAL1832
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
fast: false
is: SBO:0000176
product: MODEL1310110003#
reversible: true
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C
modifier: MODEL1310110003#

metaR r1429
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
type: Reaction
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110003#
reactant: MODEL1310110003#
name: Free diffusion
kinetic law: MODEL1310110003#
is described by: ECO:0000000

metaM HC01412 m
has only substance units: false
name: trans-tetradec-2-enoyl-CoA(4-)
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
is: CHEBI:61405
initial concentration: 1.0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_7f6a1fd9_80d6_4991_93ec_38831acf4a3f
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:93034
constant: false
has only substance units: false
is: Q96P26
name: NT5C1B
is: SBO:0000252

metaR r0502
is described by: ECO:0000000
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.1.113
is: SBO:0000176
modifier: MODEL1310110003#
product: MODEL1310110003#
fast: false

metaR NTD11
modifier: MODEL1310110003#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110003#
reversible: false
name: 5'-nucleotidase (IMP)
is version of: http://identifiers.org/ec-code/3.1.3.5
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000269
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) SUBSYSTEM: Purine catabolism EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:11133996 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31

metaR MACACI
name: maleylacetoacetate isomerase
is: SBO:0000176
product: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.18
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
reversible: false
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_b1d88b4a_6c66_4a35_a915_24c22a60bfbc
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:314
type: Species
is: O75106
initial amount: NaN
name: AOC2
has only substance units: false

metaR AIRCr
product: MODEL1310110003#
name: phosphoribosylaminoimidazole carboxylase
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/6.3.2.6
modifier: MODEL1310110003#
fast: false
reversible: true
reactant: MODEL1310110003#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_51517b10_0cc0_4f97_9457_a6cb594a887f
name: GCNT1
is encoded by: hsa:2650
is: SBO:0000252
is: Q02742
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
constant: false

metaM o2s n
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
is: HMDB02168
name: superoxide
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18421
constant: false
type: Species
initial amount: NaN

metaR VALLAT1tc
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaR r0584
fast: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is: SBO:0000176
product: MODEL1310110003#
reversible: true
type: Reaction
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9

metaR r0797
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
name: glycine N-choloyltransferase EC:2.3.1.65
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110003#
is: SBO:0000176
type: Reaction

metaM creat c
initial concentration: 1.0
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
boundary condition: false
is: CHEBI:16919
is: HMDB00064
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: creatine
constant: false
type: Species

metaM thcholstoic x
constant: false
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:18402
initial concentration: 1.0
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
type: Species
has only substance units: false
is: HMDB03873

http://identifiers.org/biomodels.db/MODEL1310110003#_0411a54b_70fb_429d_b332_643612e6f80f
initial amount: NaN
name: DGUOK
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
is: E5KSL6
is encoded by: hsa:1716
type: Species

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaM prpp c
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
boundary condition: false
is: CHEBI:58017
initial amount: NaN
initial concentration: 1.0
is: C00119
is: HMDB00280
constant: false
name: 5-Phospho-alpha-D-ribose 1-diphosphate
type: Species
is: SBO:0000247
has only substance units: false

metaR NDPK10
modifier: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#
reactant: MODEL1310110003#
name: nucleoside-diphosphate kinase (ATP:dIDP)
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
kinetic law: MODEL1310110003#
is described by: ECO:0000134
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction

metaM tsul c
type: Species
initial amount: NaN
name: thiosulfate(2-)
is: HMDB00257
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:16094
has only substance units: false
constant: false
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320

metaR r0917
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
type: Reaction

metaR ARACHCPT1
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
name: carnitine transferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
product: MODEL1310110003#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaM dolmanp U c
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
constant: false
type: Species
name: Dolichyl phosphate D-mannose, human uterine homolog
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15809
boundary condition: false
has only substance units: false

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM ksi pre25 g
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: C00130
is: CHEBI:58053
has only substance units: false
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 25
boundary condition: false
notes: FORMULA: C199H319N14O163S7X CHARGE: -8

metaR EX ascb L LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Ascorbate exchange
type: Reaction

metaR r0644
is described by: ECO:0000000
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
product: MODEL1310110003#
reversible: true
fast: false
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction

metaR EX leuktrD4 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene D4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_d1ab2903_8fe8_4bf5_a3b0_44431107a78e
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:AI373818
initial concentration: NaN
name: _AI373818_1_m
has only substance units: false
boundary condition: true

metaM pan4p c
is: CHEBI:47942
name: Pantetheine 4'-phosphate
is: HMDB01416
is: SBO:0000247
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
is: C01134
initial concentration: 1.0
type: Species
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134

metaR RE2626C
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is: SBO:0000176
reactant: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
fast: false
name: RE2626
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_6eac3626_e1f4_4ba1_a855_56333f6b8cc3
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: _8781_1_c
is encoded by: hsa:8781
initial amount: NaN
type: Species
constant: false

metaR DOPAtu
product: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
reversible: true
name: Dopamine uniport
is described by: ECO:0000269

metaR KYNAKGAT
is: SBO:0000176
fast: false
reversible: false
name: L-Kynurenine:2-oxoglutarate aminotransferase
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.64
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.7

metaR r1427
product: MODEL1310110003#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
kinetic law: MODEL1310110003#
reversible: false
reactant: MODEL1310110003#
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction

metaR GULLACter
fast: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
name: gulonolactone endoplasmic reticular transport
reactant: MODEL1310110003#
type: Reaction
reversible: false
product: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_d86a73c0_6a89_4e90_83b9_962a3e67e970
is encoded by: hsa:4538
type: Species
name: ND4
is: P03905
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_823c9893_f70b_45af_a486_04a94ad4a424
is: B2RDZ2
is: SBO:0000252
constant: false
is encoded by: hsa:55312
initial amount: NaN
name: RFK
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_0ab101bc_3864_479a_bc05_a1e3fbb1a2fa
name: NOS1
type: Species
is: B4DG68
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4842

metaM 4hpro LT c
name: trans-4-hydroxy-L-proline
is: HMDB00725
type: Species
initial amount: NaN
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:18095
constant: false
is: SBO:0000247

metaM amp c
name: AMP
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: HMDB00045
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
is: C00020
initial amount: NaN
is: CHEBI:3322

metaM leuktrC4 c
type: Species
name: leukotriene C4(2-)
boundary condition: false
initial amount: NaN
is: HMDB01198
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: CHEBI:57973
is: SBO:0000247

metaR PDHm
is: SBO:0000176
name: pyruvate dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.4.1
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (1738.1 and 8050.1) and (5161.1 and 5162.1) and (1737.1) or (1738.1 and 8050.1) and (5160.1 and 5162.1) and (1737.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.3.1.12 Confidence Level: 0 AUTHORS: PMID:12372595,PMID:16436377 NOTES:12372595 - expression; 16436377 - biochemical, tissue-specific
modifier: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/2.3.1.12
product: MODEL1310110003#
is described by: ECO:0000134
fast: false
reactant: MODEL1310110003#
reversible: false

metaM co2 c
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species
is: C00011
notes: FORMULA: CO2 CHARGE: 0
boundary condition: false
is: HMDB01967
has only substance units: false
initial amount: NaN
name: CO2
is: CHEBI:3313

metaM cmp c
is: CHEBI:60377
initial concentration: 1.0
name: CMP
constant: false
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: C00055
is: HMDB00095

metaR r0641
reactant: MODEL1310110003#
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.4
modifier: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
kinetic law: MODEL1310110003#
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2
type: Reaction
is described by: ECO:0000000

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaR r0474
reactant: MODEL1310110003#
product: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
reversible: true
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaM Ser Thr l
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0
is: HMDB00224
constant: false
type: Species
initial amount: NaN
is: CHEBI:58190
is: SBO:0000247
name: protein-linked serine or threonine residue (O-glycosylation site)
has only substance units: false
boundary condition: false

metaR FAEL183
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
is described by: ECO:0000000
product: MODEL1310110003#
kinetic law: MODEL1310110003#
name: fatty-acyl-CoA elongation (n-C18:3CoA)
reversible: false
modifier: MODEL1310110003#
is: SBO:0000176
fast: false
reactant: MODEL1310110003#
type: Reaction

metaM o2s m
is: C00704
constant: false
is: HMDB02168
type: Species
name: Superoxide anion
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:18421
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704

http://identifiers.org/biomodels.db/MODEL1310110003#_41ab9d64_b1bf_4ce7_b83c_2fb0ea82a305
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: _AI345944_1_m
is encoded by: hsa:AI345944

metaM Sfglutth c
initial concentration: 1.0
constant: false
is: HMDB01550
name: S-formylglutathionate(1-)
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
boundary condition: false
is: CHEBI:57688
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_de52a25d_e779_4a3a_8d81_53b3fa651718
name: ABCB4
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5244
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_f7012f79_9cae_43ee_89d3_844d3832a13a
constant: false
is encoded by: hsa:4698
initial amount: NaN
boundary condition: true
has only substance units: false
name: NDUFA5
is: Q16718
type: Species
initial concentration: NaN
is: SBO:0000252

metaR r0911
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110003#
name: Facilitated diffusion
product: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:
reactant: MODEL1310110003#

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_944a4d80_e085_44cd_90f1_8a1ea7bbc817
has only substance units: false
boundary condition: true
is encoded by: hsa:195814
initial concentration: NaN
name: SDR16C5
is: B3KT84
constant: false
type: Species
is: SBO:0000252
initial amount: NaN

metaM glcur r
name: D-glucuronate
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
is: CHEBI:15748
is: HMDB00127
has only substance units: false

metaR HS1ly
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.10.1.1
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
fast: false
modifier: MODEL1310110003#
product: MODEL1310110003#
name: heparan-N-sulfatase, lysosomal
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#

metaR r1428
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is described by: ECO:0000000
product: MODEL1310110003#
type: Reaction
name: Free diffusion
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
fast: false

metaM xol7ah3 c
name: 5beta-cholestane-3alpha,7alpha,26-triol
is: HMDB12455
type: Species
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28540

metaR 34DHPLACOX NADP
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (222.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
name: 3,4-Dihydroxyphenylacetaldehyde:NADP+ oxidoreductase
is described by: ECO:0000269
product: MODEL1310110003#
fast: false
is: SBO:0000176
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true

metaR r2380
reversible: true
fast: false
product: MODEL1310110003#
is: SBO:0000185
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_861e6768_9c73_4234_b9b8_43191925416c
initial amount: NaN
is encoded by: hsa:23563
type: Species
name: CHST5
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaM 2mb2coa m
initial amount: NaN
is: CHEBI:57337
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
constant: false
name: 2-methylcrotonoyl-CoA(4-)
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB02054
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_460da99b_d1af_4303_ad83_ac76b9155333
has only substance units: false
initial concentration: NaN
name: PAPSS2
initial amount: NaN
is: O95340
boundary condition: true
type: Species
is encoded by: hsa:9060
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_a60dde9b_c120_4706_b974_4aeeeb46597b
type: Species
is: SBO:0000252
initial concentration: NaN
name: SLC27A2
is: O14975
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:11001

metaM ksi pre2 g
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 2
initial concentration: 1.0
type: Species
is: HMDB00175
is: CHEBI:58053
is: C00130
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C87H142N6O62X CHARGE: -1
boundary condition: false

metaM tdchola x
initial concentration: 1.0
is: HMDB00951
name: taurochenodeoxycholate
is: CHEBI:9407
type: Species
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_6e3441b2_20d8_499f_b08c_b9eeb7d5592b
has only substance units: false
constant: false
is encoded by: hsa:50700
initial concentration: NaN
is: Q9NYR8
is: SBO:0000252
boundary condition: true
name: RDH8
initial amount: NaN
type: Species

metaM mal L e
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00156
name: (S)-malate(2-)
is: CHEBI:15589
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
has only substance units: false
constant: false
type: Species
boundary condition: false

metaR r0642
is described by: ECO:0000000
product: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
reversible: true
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:

metaR FAEL184
name: fatty-acyl-CoA elongation (n-C20:4CoA)
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
is described by: ECO:0000000
fast: false

metaR r1639
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110003#
type: Reaction
reversible: true
product: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
is: SBO:0000185
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_8762e7f0_b5c7_4878_9ace_6d844d15ede0
boundary condition: true
name: ALDH3A1
initial concentration: NaN
constant: false
is encoded by: hsa:218
initial amount: NaN
has only substance units: false
type: Species
is: P30838
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_6f4bced9_b0a6_42f8_b26f_f79aff0c00b2
boundary condition: true
is: A6NED0
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: GSTZ1
is encoded by: hsa:2954

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

metaM mi14p n
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00968
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
initial concentration: 1.0
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
type: Species
constant: false
is: CHEBI:58282
boundary condition: false

metaR r1538
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
modifier: MODEL1310110003#
type: Reaction
reversible: false
is: SBO:0000185
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.17.4.1
kinetic law: MODEL1310110003#
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
fast: false
product: MODEL1310110003#

metaM xoldiolone c
initial amount: NaN
is: HMDB02197
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:28477
constant: false
is: SBO:0000247
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial concentration: 1.0

metaR MI1P Dtn
is described by: ECO:0000000
kinetic law: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
reversible: true
name: inositol 1-phosphate nuclear transport (diffusion)
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110003#
fast: false

metaR PRPNCOAHYDm
reactant: MODEL1310110003#
reversible: false
modifier: MODEL1310110003#
type: Reaction
name: Propenoyl-CoA hydrolase (m)
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) or (549.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 4.2.1.17 Confidence Level: 1 AUTHORS: PMID:8824301 NOTES:SAB made up name because name in KEGG seemed wrong. in vitro assay
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.18
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110003#
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_37313046_32b9_4f82_93f7_0fdece3797d4
is: A8K7W0
type: Species
has only substance units: false
name: VNN2
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:8875
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_30f323fa_a873_4ab9_a9af_5e77fd9e9b6e
is encoded by: hsa:9435
is: Q9Y4C5
name: CHST2
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_0e97c5d3_f84b_4eae_b8ad_9241098da46c
constant: false
is encoded by: hsa:51102
initial amount: NaN
name: MECR
has only substance units: false
initial concentration: NaN
is: Q9BV79
is: SBO:0000252
type: Species
boundary condition: true

metaM amp e
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial concentration: 1.0
is: CHEBI:456215
has only substance units: false
initial amount: NaN
is: HMDB00045
is: C00020
constant: false
is: SBO:0000247
name: AMP
type: Species

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_59aec9e2_c3e6_4319_998a_9d8e8478e150
is encoded by: hsa:PRO1933
has only substance units: false
constant: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: _PRO1933_1_m
is: SBO:0000252

metaR EX coa LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for coa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_c9627ee7_11d6_418e_a661_512bac691dbe
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: BDH1
is encoded by: hsa:622
is: Q02338
type: Species
initial concentration: NaN

metaR B3GALT5g
name: Beta-1,3-galactosyltransferase 5
reactant: MODEL1310110003#
is described by: ECO:0000269
product: MODEL1310110003#
type: Reaction
reversible: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (10317.4) or (10317.1) or (10317.3) or (10317.2) or (10317.5) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
modifier: MODEL1310110003#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_d704a7fa_e1b4_492c_a41d_12fa6771d91a
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1716
initial amount: NaN
is: SBO:0000252
name: DGUOK
constant: false

metaR r0913
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110003#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_e4c8a680_9e50_43df_a80c_d531ee34b570
is: SBO:0000252
is encoded by: hsa:4047
name: LSS
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: E9PEI9
has only substance units: false

metaR UMPK6n
name: UMP kinase (dCTP),nuclear
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110003#
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_3c44bc26_e68a_4332_beef_a669fae4e619
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:51166
boundary condition: true
constant: false
initial concentration: NaN
is: Q4W5N8
has only substance units: false
name: AADAT

http://identifiers.org/biomodels.db/MODEL1310110003#_3e54d819_9656_4f2f_a357_4a97fd3658b7
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:4048
has only substance units: false
is: P09960
initial amount: NaN
initial concentration: NaN
name: LTA4H
constant: false

metaR r2382
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
is: SBO:0000185
type: Reaction
fast: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_7e95dbfe_27d9_4b10_a79b_c847ce96c24c
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: DGKZ
is: G3V0F6
is encoded by: hsa:8525
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_2a113066_1582_4e40_a248_e0578e40829d
initial amount: NaN
name: IDH1
boundary condition: true
is: SBO:0000252
type: Species
is: O75874
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3417

http://identifiers.org/biomodels.db/MODEL1310110003#_99205171_5700_4a75_8352_d258b2ed69d6
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
is: Q9P1E4
has only substance units: false
name: MAN2A2
is encoded by: hsa:4122

http://identifiers.org/biomodels.db/MODEL1310110003#_a4ec8176_4728_432c_99c3_1933b970065f
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
name: GUK1
boundary condition: true
is encoded by: hsa:2987
initial concentration: NaN
is: Q16774

metaR r0475
kinetic law: MODEL1310110003#
reversible: true
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is described by: ECO:0000000

metaM mal L c
initial concentration: 1.0
name: (S)-malate(2-)
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: SBO:0000247
is: CHEBI:15589
is: HMDB00156
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_e8267670_a3b8_4c64_80e7_7ed1e8fea6ff
initial concentration: NaN
is: SBO:0000252
is: P36269
is encoded by: hsa:2687
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
name: GGT5
type: Species

metaR BTNDe
fast: false
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.5.1.12
reversible: false
product: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:7509806,PMID:8001986 NOTES:Also acts on biotin esters IT
name: biotinidase (biotin), extracellular
type: Reaction

metaM prostgd2 c
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
is: HMDB01403
type: Species
is: SBO:0000247
name: prostaglandin D2(1-)

metaR r1637
is described by: ECO:0000000
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_40465d4a_6b08_406d_85d2_39dd1bb3e3e1
initial amount: NaN
is: SBO:0000252
name: MTHFD1L
type: Species
is encoded by: hsa:25902
initial concentration: NaN
is: B2RD24
constant: false
boundary condition: true
has only substance units: false

metaR AG13T11g
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
reversible: false
product: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaM L2aadp6sa c
initial concentration: 1.0
type: Species
is: CHEBI:17917
is: SBO:0000247
boundary condition: false
has only substance units: false
name: L-allysine
initial amount: NaN
constant: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
is: HMDB01263

http://identifiers.org/biomodels.db/MODEL1310110003#_5c7e5b52_ffde_45cb_88c0_65a2ffb286f8
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:873
name: CBR1
is: SBO:0000252
boundary condition: true
is: P16152

metaR 3HBCOAHLm
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM
kinetic law: MODEL1310110003#
type: Reaction
reversible: false
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
is described by: ECO:0000000
is: SBO:0000176

metaR FAOXC160
product: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
reactant: MODEL1310110003#
is described by: ECO:0000269
modifier: MODEL1310110003#
type: Reaction
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110003#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM 2mbcoa m
initial amount: NaN
is: HMDB01041
name: 2-methylbutanoyl-CoA(4-)
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
is: SBO:0000247
type: Species
is: CHEBI:57336

http://identifiers.org/biomodels.db/MODEL1310110003#_3c2e7674_db37_481a_913f_d1596702e4e6
is: SBO:0000252
initial amount: NaN
name: DGUOK
constant: false
boundary condition: true
is: E5KSL5
type: Species
has only substance units: false
is encoded by: hsa:1716
initial concentration: NaN

metaR r1742
reactant: MODEL1310110003#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185

metaR Coqe
fast: false
name: Transport of q10
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000134
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_4ceb91c5_3f84_4596_a5d4_0c181d8328ba
is: O75752
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
name: B3GALNT1
is encoded by: hsa:8706

metaM ppi x
is: HMDB00250
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
initial amount: NaN
name: Diphosphate
constant: false
boundary condition: false
is: SBO:0000247
is: C00013

metaM hs deg11 l
is: CHEBI:57737
boundary condition: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
constant: false
is: HMDB00868
type: Species
name: heparan sulfate, degradation product 11
is: SBO:0000247
has only substance units: false

metaR EX akg LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Oxoglutarate exchange
type: Reaction

metaR PA HSter
kinetic law: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
type: Reaction
product: MODEL1310110003#
name: phosphatidate scramblase
reactant: MODEL1310110003#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_4782fc02_9d60_457a_8dc8_09690403c0ae
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q9NWU1
is encoded by: hsa:54995
initial concentration: NaN
name: OXSM
constant: false

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

metaM cholcoa x
is: HMDB01374
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
is: SBO:0000247
name: choloyl-CoA(4-)
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:57373
boundary condition: false
initial concentration: 1.0

metaR DOLMANP Uter
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reversible: false
type: Reaction
product: MODEL1310110003#
name: dolichol-phosphate mannose flippase (uterus)
reactant: MODEL1310110003#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110003#

metaR r1638
product: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110003#
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110003#_72c6dd04_3f02_4897_9ef9_0cf83ad0b3b7
is encoded by: hsa:257202
boundary condition: true
is: P59796
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
name: GPX6

metaR GLCNACASE5ly
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.2.1.50
is described by: ECO:0000000
product: MODEL1310110003#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
name: alpha-N-acetylglucosaminidase, lysosomal
kinetic law: MODEL1310110003#
fast: false
is: SBO:0000176

metaM tsul m
is: HMDB00257
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: O3S2 CHARGE: -2 INCHI: InChI=1S/H2O3S2/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 EHMN_ABBREVIATION: C00320
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:16094
name: thiosulfate(2-)

metaR r1743
product: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
reversible: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_6cfd057b_c656_43ec_8795_d177b249e10c
initial concentration: NaN
is encoded by: hsa:491
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
type: Species
is: Q4J699
name: ATP2B2
is: SBO:0000252

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

metaM gly m
is: C00037
is: HMDB00123
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: Glycine
initial concentration: 1.0
type: Species
is: CHEBI:15428
constant: false
has only substance units: false
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037

http://identifiers.org/biomodels.db/MODEL1310110003#_38a9eecf_a050_4973_9d51_1af0caa129e4
name: CHST3
boundary condition: true
is: Q7LGC8
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:9469
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_ffcd1006_0dc7_446b_b101_7181e844cdf6
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AD000092
is: SBO:0000252
has only substance units: false
type: Species
constant: false
name: _AD000092_1_c

metaR PHEt4
kinetic law: MODEL1310110003#
is: SBO:0000185
type: Reaction
name: L-phenylalanine transport in via sodium symport
reactant: MODEL1310110003#
fast: false
product: MODEL1310110003#
is described by: ECO:0000269
modifier: MODEL1310110003#
reversible: false
notes: GENE_ASSOCIATION: (54407.1) or (84889.1) or (11254.1) or (6542.1) or (81539.1) or (6541.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB

http://identifiers.org/biomodels.db/MODEL1310110003#_8373a123_f74c_42b2_9392_75e07f68cf74
initial amount: NaN
is: SBO:0000252
name: _AW277253_1_c
type: Species
is encoded by: hsa:AW277253
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

metaM prostgd2 e
name: prostaglandin D2(1-)
is: CHEBI:57406
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB01403
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false

metaR r1635
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_6ef86838_67e0_4489_873c_8f601f970e91
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: P35218
is encoded by: hsa:763
is: SBO:0000252
boundary condition: true
name: CA5A

http://identifiers.org/biomodels.db/MODEL1310110003#_9cce8aa1_5e77_4883_8879_7ef3fdce38c6
initial amount: NaN
type: Species
is: SBO:0000252
name: ALG5
boundary condition: true
constant: false
is encoded by: hsa:29880
initial concentration: NaN
is: Q9Y673
has only substance units: false

metaR r0472
kinetic law: MODEL1310110003#
reversible: true
fast: false
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110003#

metaR MM8Ber
is version of: http://identifiers.org/ec-code/3.2.1.113
modifier: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000176
fast: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, endoplasmic reticulum
type: Reaction
reactant: MODEL1310110003#
reversible: false
notes: GENE_ASSOCIATION: (11253.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10409699,PMID:9592125 NOTES:NCD
kinetic law: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_0eb0515c_97da_49cf_9ff1_d9c7b01a20d0
is: SBO:0000252
is: B4DG68
name: NOS1
initial concentration: NaN
constant: false
is encoded by: hsa:4842
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN

metaM m5masnB2 g
is: CHEBI:58433
initial amount: NaN
initial concentration: 1.0
is: HMDB02985
notes: FORMULA: C52H87N2O40X CHARGE: 0
has only substance units: false
is: SBO:0000247
constant: false
boundary condition: false
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species

metaM leuktrC4 e
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: HMDB01198
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: CHEBI:57973
name: leukotriene C4(2-)

metaR THRGLYexR
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110003#
fast: false
name: L-threonine/glycine reversible exchange

metaM pail4p hs c
is: CHEBI:58178
boundary condition: false
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_84cfad13_f249_4b40_9cec_0cbdb1eeb20d
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

metaR PI45P5P
fast: false
reactant: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
kinetic law: MODEL1310110003#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.3.36
is described by: ECO:0000000
type: Reaction
reversible: false

metaR XOL7AONEtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
fast: false
reactant: MODEL1310110003#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_2533c5a9_cb19_4d52_aa4d_0711e4aab0ed
name: ND1
is: SBO:0000252
is encoded by: hsa:4535
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: Q85KV6
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_d5242ba8_fa5d_4e38_89ce_6574de658593
type: Species
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: B4DDW0
boundary condition: true
is encoded by: hsa:51109
is: SBO:0000252
name: RDH11

http://identifiers.org/biomodels.db/MODEL1310110003#_dffdbcfd_3ab2_43c3_b20d_af63a87f9958
is: SBO:0000252
boundary condition: true
name: ALDH3A2
constant: false
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:224
is: P51648

http://identifiers.org/biomodels.db/MODEL1310110003#_a816d585_c3be_4f78_a054_e94f73355189
initial amount: NaN
is encoded by: hsa:10841
is: SBO:0000252
boundary condition: true
has only substance units: false
name: FTCD
constant: false
initial concentration: NaN
type: Species

metaR OCDCAtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
name: fatty acid transport via diffusion
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110003#
is described by: ECO:0000000
fast: false

metaR r0853
fast: false
reversible: false
type: Reaction
name: Facilitated diffusion
is: SBO:0000185
reactant: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:8132483 NOTES:
kinetic law: MODEL1310110003#

metaR r1636
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110003#

metaR r1741
product: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110003#
reversible: false
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110003#

metaR S6T11g
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110003#
reversible: false
kinetic law: MODEL1310110003#
fast: false

metaM Ser Thr g
notes: FORMULA: XH CHARGE: 0
has only substance units: false
is: HMDB00143
is: C00124
type: Species
is: SBO:0000247
name: protein-linked serine or threonine residue (O-glycosylation site)
constant: false
initial concentration: 1.0
is: CHEBI:0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_a2d3c070_fb50_4e30_ade8_fc85e0da5b46
is: F8W1L5
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:2819
has only substance units: false
name: GPD1
constant: false
is: SBO:0000252

metaM CE5120 m
is: SBO:0000247
has only substance units: false
is: CHEBI:15748
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00127
name: trans-2-cis-8-tetradecadienoyl-CoA
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_4e3036f4_a77b_4898_876b_c547d49a11c9
constant: false
has only substance units: false
initial concentration: NaN
name: ST3GAL5
type: Species
boundary condition: true
is: Q9UNP4
is encoded by: hsa:8869
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_5c34aedf_87b1_4e53_be3d_43780cf2be9b
name: DUOX2
is: Q9NRD8
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:50506
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_645aa229_57fa_4615_a681_b01a6ad6ba8a
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
is: P48735
is: SBO:0000252
constant: false
is encoded by: hsa:3418
name: IDH2
has only substance units: false

metaR r2376
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110003#
type: Reaction
reversible: true
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#

metaM pnto R e
is: CHEBI:7916
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00210
name: (R)-Pantothenate
type: Species
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568

http://identifiers.org/biomodels.db/MODEL1310110003#_7e19a8c8_6e88_4409_bb3c_e7d987020098
is: Q99685
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:11343
name: MGLL
boundary condition: true
has only substance units: false

metaM L2aadp c
name: L-2-aminoadipate(1-)
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00510
has only substance units: false
is: CHEBI:58672
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_d5b9aa0e_7305_409f_a8c9_a0a76bb02cb0
initial concentration: NaN
type: Species
constant: false
is: O43708
boundary condition: true
is encoded by: hsa:2954
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: GSTZ1

metaM nac e
type: Species
is: HMDB01488
is: C00253
initial amount: NaN
is: CHEBI:0
name: Nicotinate
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C6H4NO2 CHARGE: -1
boundary condition: false
has only substance units: false

metaM xoldioloneh c
initial amount: NaN
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
is: SBO:0000247
boundary condition: false
is: CHEBI:2288
constant: false
type: Species
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
is: HMDB06887
initial concentration: 1.0
has only substance units: false

metaR RE1527M
product: MODEL1310110003#
is described by: ECO:0000000
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
fast: false
type: Reaction
is: SBO:0000176
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.107
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
name: RE1527

http://identifiers.org/biomodels.db/MODEL1310110003#_1d01f6bc_a0f7_438f_b47c_f104787d4614
is: SBO:0000252
type: Species
name: DDOST
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P39656
has only substance units: false
constant: false
is encoded by: hsa:1650

metaM C02470 c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/5485
is: C02470
name: Xanthurenic acid
boundary condition: false
is: HMDB00881

metaR RE1534M
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110003#
reactant: MODEL1310110003#
name: RE1534
kinetic law: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false

metaM HC02175 e
name: caprate
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
is: CHEBI:27689
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_6dca7774_fa50_49df_8125_b704ca89e152
name: DHFR
is: SBO:0000252
initial amount: NaN
is: P00374
type: Species
constant: false
is encoded by: hsa:1719
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM galgbside hs g
constant: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
name: galactosylgloboside
is: CHEBI:18259
has only substance units: false
initial amount: NaN
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110003#_e35a7452_c329_4b65_a319_0bae2b7b7197
initial concentration: NaN
has only substance units: false
is: P04745
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: AMY1C
is encoded by: hsa:278

metaM dolmanp U r
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15809
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
boundary condition: false
name: Dolichyl phosphate D-mannose, human uterine homolog
initial amount: NaN
constant: false

metaM gal e
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0
initial concentration: 1.0
has only substance units: false
is: HMDB00143
is: C00124
is: CHEBI:0
type: Species
constant: false
is: SBO:0000247
name: D-Galactose

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_d02340b6_d8b3_4f72_8d82_dae27fdddb7b
is: Q13454
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:7991
has only substance units: false
name: TUSC3
type: Species

metaR PRPPS
modifier: MODEL1310110003#
product: MODEL1310110003#
name: phosphoribosylpyrophosphate synthetase
kinetic law: MODEL1310110003#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/2.7.6.1
is: SBO:0000176
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:

metaM o2s e
is: HMDB02168
is: CHEBI:18421
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
boundary condition: false
has only substance units: false
name: superoxide

metaM ksii core2 e
type: Species
initial concentration: 1.0
is: CHEBI:17268
is: HMDB00211
name: keratan sulfate II (core 2-linked)
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110003#_7788bff4_29c3_441d_96ff_ffcff2454ec6
name: ALG2
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:85365

metaR r2377
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
reversible: true

metaM na1 c
is: HMDB00588
is: CHEBI:4541
name: Sodium
boundary condition: false
is: C01330
constant: false
notes: FORMULA: Na CHARGE: 1
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM hxan c
constant: false
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: CHEBI:17368
is: SBO:0000247
initial amount: NaN
is: C00262
type: Species
is: HMDB00157
boundary condition: false
name: Hypoxanthine
initial concentration: 1.0
has only substance units: false

metaM 3mob m
type: Species
constant: false
is: HMDB00019
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:11851
has only substance units: false
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial amount: NaN

metaM ksi pre3 g
notes: FORMULA: C93H152N6O67X CHARGE: -1
is: HMDB00175
initial amount: NaN
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 3
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
is: C00130
has only substance units: false

metaM nadh c
constant: false
is: http://identifiers.org/pubchem.compound/3306
name: Nicotinamide adenine dinucleotide - reduced
is: HMDB01487
is: CHEBI:57945
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00004

metaR RE1709C
name: RE1709
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110003#

metaR r0013
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
modifier: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
type: Reaction
is: SBO:0000176
product: MODEL1310110003#
kinetic law: MODEL1310110003#
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
reversible: false

metaM urate e
boundary condition: false
type: Species
has only substance units: false
constant: false
is: CHEBI:17775
is: HMDB00289
name: Urate
is: SBO:0000247
is: C00366
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
initial amount: NaN
initial concentration: 1.0

metaR DSAT
reversible: false
type: Reaction
fast: false
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ
is described by: ECO:0000000
is: SBO:0000176
name: dihydrosphingosine N-acyltransferase

http://identifiers.org/biomodels.db/MODEL1310110003#_9e99ddf0_86c1_454d_a731_be584480761f
initial concentration: NaN
has only substance units: false
type: Species
is: Q53FV7
is: SBO:0000252
constant: false
initial amount: NaN
name: CPT1B
is encoded by: hsa:1375
boundary condition: true

metaR ABUTt2r
modifier: MODEL1310110003#
name: 4-aminobutyrate reversible transport in via proton symport
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
reversible: true
fast: false
is: SBO:0000185
product: MODEL1310110003#
type: Reaction
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110003#_bec30dda_cf63_4295_84fe_8678e6fbea46
has only substance units: false
name: PYCR1
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:5831
initial amount: NaN
is: P32322
is: SBO:0000252
boundary condition: true

metaM m5mpdol U r
is: SBO:0000247
type: Species
is: CHEBI:37634
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20

metaM pacald c
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
has only substance units: false
type: Species
is: HMDB06236
is: CHEBI:16424
name: phenylacetaldehyde
initial amount: NaN

metaR r2378
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110003#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
reversible: true
is: SBO:0000185

metaR GLYCt
reactant: MODEL1310110003#
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
reversible: true
kinetic law: MODEL1310110003#
type: Reaction
name: glycerol transport via channel
is: SBO:0000185
is described by: ECO:0000000

metaM CE5117 m
is: CHEBI:15748
has only substance units: false
is: HMDB00127
constant: false
initial amount: NaN
type: Species
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
is: SBO:0000247

metaM HC02175 c
name: caprate
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C10H19O2 CHARGE: -1 INCHI: InChI=1S/C10H20O2/c1-2-3-4-5-6-7-8-9-10(11)12/h2-9H2,1H3,(H,11,12)/p-1
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:27689
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_781353f4_9407_44b7_94f7_cfa406e6c975
type: Species
initial amount: NaN
is: P42765
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: ACAA2
is encoded by: hsa:10449

metaR ANTHte
type: Reaction
name: Transport of anthranilate
product: MODEL1310110003#
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110003#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_8015917e_1402_4446_bd2e_e16a7e309773
initial concentration: NaN
constant: false
is: B3KRT1
is: SBO:0000252
name: ISYNA1
type: Species
is encoded by: hsa:51477
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_423d6a1e_5c41_48da_bcdb_a87b90463cb2
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: B3KWF4
name: GALNT11
is: SBO:0000252
boundary condition: true
is encoded by: hsa:63917

metaM dolp U r
has only substance units: false
boundary condition: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
type: Species
name: dolichyl phosphate(2-)
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR DGSNtm
kinetic law: MODEL1310110003#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
reactant: MODEL1310110003#
is described by: ECO:0000000
name: deoyguanosine transport in mitochondria
product: MODEL1310110003#
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_f84be82d_741d_43bb_a12c_29dbf293a914
is encoded by: hsa:204
type: Species
name: AK2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN

metaM gullac c
type: Species
is: CHEBI:17587
initial concentration: 1.0
is: HMDB03466
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
name: L-gulono-1,4-lactone
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110003#_3ebb7dc8_203d_4ea2_8913_88688d30be8b
is: Q06830
type: Species
has only substance units: false
name: PRDX1
initial amount: NaN
is encoded by: hsa:5052
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_3e43163e_a282_4133_95c6_ee8ef0347642
initial concentration: NaN
boundary condition: true
is: Q8WZ48
type: Species
is: SBO:0000252
constant: false
has only substance units: false
name: CPT1A
is encoded by: hsa:1374
initial amount: NaN

metaR r2379
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110003#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110003#
product: MODEL1310110003#
type: Reaction

metaM ksii core2 g
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: CHEBI:57255
type: Species
is: HMDB01014
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
name: keratan sulfate II (core 2-linked)
has only substance units: false
boundary condition: false

metaM 2dr5p c
initial concentration: 1.0
is: HMDB01031
is: CHEBI:57651
boundary condition: false
has only substance units: false
name: 2-deoxy-D-ribose 5-phosphate(2-)
type: Species
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673

http://identifiers.org/biomodels.db/MODEL1310110003#_171fdaad_4fc6_4909_953c_7f5c3ef72204
initial amount: NaN
name: SLC22A1
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6580
boundary condition: true
is: SBO:0000252
is: O15245
constant: false

metaM o2s c
boundary condition: false
constant: false
type: Species
is: SBO:0000247
name: superoxide
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
initial concentration: 1.0
is: CHEBI:18421
initial amount: NaN
is: HMDB02168

metaM ppi r
constant: false
boundary condition: false
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
name: Diphosphate
initial amount: NaN
is: HMDB00250
initial concentration: 1.0
has only substance units: false
is: C00013
is: SBO:0000247

metaM zymstnl r
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:16608
is: HMDB06841
name: 5alpha-cholest-8-en-3beta-ol
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845

http://identifiers.org/biomodels.db/MODEL1310110003#_bbc2c1ef_d0ea_44ea_bc75_1798d3952c54
name: ST3GAL4
constant: false
is: SBO:0000252
type: Species
is: Q6IBE6
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6484
has only substance units: false
initial amount: NaN

metaR ACACT10m
fast: false
kinetic law: MODEL1310110003#
is: SBO:0000176
reactant: MODEL1310110003#
is described by: ECO:0000134
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
type: Reaction
product: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.9

http://identifiers.org/biomodels.db/MODEL1310110003#_0e303df3_674f_4b0f_99d3_ca4f867629af
constant: false
is: SBO:0000252
is encoded by: hsa:3038
is: Q96RV2
initial amount: NaN
boundary condition: true
name: HAS3
initial concentration: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_8cca70af_a3cd_4f96_83da_9e250d9d7c3e
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
is: Q02218
is encoded by: hsa:4967
name: OGDH
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_7d8a914e_47e2_4f39_aa92_90bb16531695
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:686
name: BTD
is: P43251
constant: false

metaR r1257
reversible: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110003#
fast: false
name: EC:6.2.1.3
is: SBO:0000176
type: Reaction

metaR ATP2ter
name: AMP/ATP transporter, endoplasmic reticulum
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#
fast: false

metaM 10fthf5glu e
boundary condition: false
notes: FORMULA: C40H45N11O19 CHARGE: -6
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00972
type: Species
name: 10-formyltetrahydrofolate-[Glu](5)
initial amount: NaN
is: CHEBI:57454

metaM 34dhphe c
has only substance units: false
initial amount: NaN
is: HMDB00181
name: L-dopa
is: CHEBI:15765
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1

metaR FAOXC2051843m
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
reactant: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
name: Beta oxidation of fatty acid
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#

metaR r2372
product: MODEL1310110003#
reactant: MODEL1310110003#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110003#
is described by: ECO:0000000

metaR r2099
is: SBO:0000185
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110003#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110003#
fast: false
product: MODEL1310110003#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_076648d3_1416_4a30_b4bf_e153149583e3
constant: false
is encoded by: hsa:4707
boundary condition: true
has only substance units: false
type: Species
is: O75438
is: SBO:0000252
initial concentration: NaN
name: NDUFB1
initial amount: NaN

metaR GLCNACT U
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
reversible: false
fast: false
product: MODEL1310110003#

metaM mlthf c
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01533
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
boundary condition: false
initial concentration: 1.0
name: 5,10-Methylenetetrahydrofolate
is: CHEBI:15636
is: C00143
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_f10aa039_31ba_46ca_9827_4204a72052e4
is encoded by: hsa:3423
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
name: IDS
is: B4DGD7
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_6279b5f7_5b78_48fe_b90a_4f2d33a98f42
has only substance units: false
name: FADS1
type: Species
is encoded by: hsa:3992
initial amount: NaN
constant: false
is: SBO:0000252
is: O60427
boundary condition: true
initial concentration: NaN

metaR URATEt
name: urate export from cytosol
reversible: false
type: Reaction
kinetic law: MODEL1310110003#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaM duri n
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00012
boundary condition: false
name: 2'-deoxyuridine
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false
initial amount: NaN
type: Species
is: CHEBI:16450

http://identifiers.org/biomodels.db/MODEL1310110003#_ef65dcce_3626_423e_aa2c_4175e78e9785
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q8N9L9
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: ACOT4
is encoded by: hsa:122970

metaR RETH
modifier: MODEL1310110003#
fast: false
is: SBO:0000176
reactant: MODEL1310110003#
reversible: false
is described by: ECO:0000000
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
is version of: http://identifiers.org/ec-code/3.1.1.3
name: retinyl ester hydrolase
type: Reaction
kinetic law: MODEL1310110003#

metaM ppcoa c
initial concentration: 1.0
type: Species
is: CHEBI:57392
initial amount: NaN
constant: false
boundary condition: false
name: Propanoyl-CoA
is: SBO:0000247
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: HMDB01275
is: C00100
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_1ddb4b26_0145_4fdc_af26_ed1e59dc3660
boundary condition: true
initial amount: NaN
constant: false
type: Species
is: E5KNH5
is encoded by: hsa:4723
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: NDUFV1

metaM 34dhphe e
has only substance units: false
notes: FORMULA: C9H11NO4 CHARGE: 0 INCHI: InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1
boundary condition: false
initial amount: NaN
is: CHEBI:15765
name: L-dopa
constant: false
is: HMDB00181
type: Species
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_2ddb86cd_56f0_4ae4_aede_baf593c610a5
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:55568
boundary condition: true
name: GALNT10
type: Species

metaR LEUKTRB4t
name: leukotriene B4 transport
reversible: true
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110003#
is: SBO:0000185
type: Reaction
product: MODEL1310110003#
fast: false

metaR r2373
type: Reaction
kinetic law: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaR EX HC00250 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of hydrosulfide
type: Reaction

metaR PAIL45P HStn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
is described by: ECO:0000000
reactant: MODEL1310110003#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_32f8e4cb_bca6_4538_8d35_79d1651b688b
initial amount: NaN
has only substance units: false
constant: false
is: P07327
is: SBO:0000252
name: ADH1A
is encoded by: hsa:124
initial concentration: NaN
type: Species
boundary condition: true

metaR NRPPHRt4 2 r
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is: SBO:0000185
reactant: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
fast: false
reversible: true
name: Norepinephrine reversible transport in via sodium symport (1:2)
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_3be9b0bc_6df1_446b_a442_e2c615baa659
is encoded by: hsa:4704
has part: O14561
is encoded by: hsa:4722
is encoded by: hsa:4536
is encoded by: hsa:4695
has part: O95167
has part: P03897
is encoded by: hsa:4716
is encoded by: hsa:4539
has part: O75251
has part: C9JT23
initial concentration: NaN
is encoded by: hsa:4538
has part: Q549M5
has part: Q6IB80
has part: F8VQS7
is encoded by: hsa:4710
has part: Q6IBB5
has only substance units: false
has part: P03915
has part: P03905
has part: B1AM93
has part: Q13454
is encoded by: hsa:4707
has part: Q16718
has part: P56556
is encoded by: hsa:4705
has part: Q6IBC4
is encoded by: hsa:4708
has part: H7C5B8
boundary condition: true
is encoded by: hsa:4711
has part: Q9Y6M9
is encoded by: hsa:4697
has part: B7Z792
initial amount: NaN
is encoded by: hsa:55967
is encoded by: hsa:51079
is: SBO:0000297
constant: false
has part: O75489
is encoded by: hsa:4728
has part: P56181
has part: P17568
is encoded by: hsa:4731
has part: O95169
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: O95299
is encoded by: hsa:4717
is encoded by: hsa:4698
is encoded by: hsa:4723
has part: Q6IBA0
has part: O43181
has part: A8K761
is encoded by: hsa:4724
is encoded by: hsa:4709
has part: O43674
has part: O43678
is encoded by: hsa:374291
has part: E5KNH5
has part: P19404
is encoded by: hsa:4540
is encoded by: hsa:4713
is encoded by: hsa:4700
has part: O43677
is encoded by: hsa:4729
is encoded by: hsa:4712
has part: Q85KV6
has part: Q6FG42
has part: Q16795
is encoded by: hsa:4535
has part: O95139
is encoded by: hsa:4694
has part: Q9P0J0
is encoded by: hsa:4715
has part: O95168
is encoded by: hsa:126328
is encoded by: hsa:7991
is encoded by: hsa:4720
is encoded by: hsa:4541

http://identifiers.org/biomodels.db/MODEL1310110003#_4672fef3_f32f_46b4_8bf3_84dec97de392
name: ALDOC
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: P09972
boundary condition: true
is encoded by: hsa:230
is: SBO:0000252
initial concentration: NaN

metaM tststerone r
initial amount: NaN
name: testosterone
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00535
is: HMDB00234
is: CHEBI:17347
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false

metaR HSAT2ly
kinetic law: MODEL1310110003#
reversible: false
product: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaR UDPGLCAter
fast: false
is described by: ECO:0000269
reversible: true
type: Reaction
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
product: MODEL1310110003#
is: SBO:0000185
modifier: MODEL1310110003#

metaM 3mob e
type: Species
is: CHEBI:11851
is: SBO:0000247
initial concentration: 1.0
name: 3-methyl-2-oxobutanoate
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00019
boundary condition: false

metaR PA HStn
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
name: phosphatidate transport, nuclear
is: SBO:0000185
type: Reaction

metaR EX CE2250 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-oxodocosanoyl-CoA exchange
type: Reaction

metaR NDP8
reversible: false
kinetic law: MODEL1310110003#
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
name: nucleoside-diphosphatase (dUDP)
is version of: http://identifiers.org/ec-code/2.7.4.9
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000269
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_c34e40ec_db76_4dac_b278_f86b78ed9490
has only substance units: false
type: Species
is encoded by: hsa:6470
is: P34896
name: SHMT1
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR EX rbt LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ribitol exchange
type: Reaction

metaM ppi m
initial concentration: 1.0
has only substance units: false
is: C00013
initial amount: NaN
constant: false
type: Species
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: SBO:0000247
is: CHEBI:33019
is: HMDB00250
name: Diphosphate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_bd8ba3bb_ba9f_44a6_9972_b0e359bcf061
constant: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:9123
is: O15427
name: SLC16A3
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_b31559ad_b58b_45e6_8dd1_1f0c5d241e80
name: IDH2
constant: false
has only substance units: false
type: Species
is: P48735
is encoded by: hsa:3418
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR r2097
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: true
is: SBO:0000185
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110003#
fast: false
type: Reaction

metaR r2374
type: Reaction
reversible: true
kinetic law: MODEL1310110003#
is: SBO:0000185
product: MODEL1310110003#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reactant: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

metaM xol7ah3 m
name: 5beta-cholestane-3alpha,7alpha,26-triol
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
is: HMDB12455
is: CHEBI:28540
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM gal l
initial concentration: 1.0
is: HMDB00143
constant: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
is: CHEBI:12936
has only substance units: false
type: Species
name: D-galactose
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_2b136e96_95c6_41b8_bf82_af5ddc69a543
initial concentration: NaN
has only substance units: false
is: H0UI06
constant: false
name: COX7A2
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:1347

http://identifiers.org/biomodels.db/MODEL1310110003#_b3af75cf_1447_4008_a303_f8650b895ebb
boundary condition: true
is encoded by: hsa:55350
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: VNN3

metaM clpn hs c
is: SBO:0000247
boundary condition: false
constant: false
name: clpn_hs[c]
is: HMDB02704
has only substance units: false
initial amount: NaN
notes: FORMULA: CHARGE: 0
type: Species
initial concentration: 1.0
is: CHEBI:21338

metaR STS1
fast: false
product: MODEL1310110003#
is: SBO:0000176
name: Steryl-sulfatase
type: Reaction
reactant: MODEL1310110003#
reversible: false
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.6.2

metaM 3dhguln c
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
name: 3-dehydro-L-gulonate
initial amount: NaN
is: HMDB06334
is: SBO:0000247
is: CHEBI:57655
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
boundary condition: false

metaM leuktrB4 c
is: CHEBI:57461
constant: false
is: HMDB01085
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
is: SBO:0000247
boundary condition: false
name: leukotriene B4(1-)
type: Species
initial concentration: 1.0
initial amount: NaN

metaM dag hs c
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
type: Species
initial amount: NaN
boundary condition: false
name: diglyceride
is: CHEBI:18035
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_7a2ff37c_85db_47de_b420_ff3fc647496c
name: MVK
initial concentration: NaN
is: SBO:0000252
is: B2RDU6
has only substance units: false
is encoded by: hsa:4598
initial amount: NaN
boundary condition: true
type: Species
constant: false

metaR DOLPMT1 Uer
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
reversible: false
type: Reaction
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.258
reactant: MODEL1310110003#
modifier: MODEL1310110003#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is: SBO:0000176
product: MODEL1310110003#
is described by: ECO:0000000

metaM ppi n
boundary condition: false
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
type: Species
initial concentration: 1.0
name: diphosphate(3-)
is: SBO:0000247
is: CHEBI:33019
is: HMDB00250
has only substance units: false
initial amount: NaN
constant: false

metaM ctp n
has only substance units: false
is: CHEBI:37563
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
name: CTP(4-)
is: SBO:0000247
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
boundary condition: false
is: HMDB00082

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaM idp n
is: SBO:0000247
is: HMDB03335
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
initial amount: NaN
constant: false
name: IDP(3-)
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:58280
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_749c4d47_1f2c_4f8f_8513_2e67058c22a8
has only substance units: false
is: SBO:0000252
name: ALDH3B1
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:221
constant: false
is: P43353

metaM HC01434 m
has only substance units: false
type: Species
initial concentration: 1.0
name: oxalatosuccinate(3-)
initial amount: NaN
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
is: CHEBI:58931
constant: false
is: SBO:0000247
boundary condition: false

metaM hxan e
constant: false
boundary condition: false
is: CHEBI:17368
has only substance units: false
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00157
name: hypoxanthine

metaR GHMT2rm
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.1.2.1
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
reversible: true
product: MODEL1310110003#
name: glycine hydroxymethyltransferase, reversible, mitochondrial
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_78270c03_cd67_41e1_bb97_e304c76894c1
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: _AI971036_1_m
initial amount: NaN
is encoded by: hsa:AI971036

metaM na1 e
name: Sodium
initial concentration: 1.0
is: C01330
constant: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: Na CHARGE: 1
is: CHEBI:4541
is: HMDB00588
has only substance units: false
is: SBO:0000247

metaR GALU
name: UTP-glucose-1-phosphate uridylyltransferase
is: SBO:0000176
kinetic law: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.7.9
is described by: ECO:0000134
fast: false
product: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y

metaR r2375
reactant: MODEL1310110003#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110003#
type: Reaction
reversible: true

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR r2098
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaM mmcoa S m
is: SBO:0000247
has only substance units: false
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
name: (S)-methylmalonyl-CoA(5-)
is: CHEBI:57327
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: HMDB02310
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_02e44ad6_65b8_4150_bd7e_a3fd3862c0e5
is: Q9P0Z9
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:51268
name: PIPOX
is: SBO:0000252

metaR r2095
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110003#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
reactant: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_b20e57f0_b0c3_49cc_847e_16018d3dbf12
initial amount: NaN
is: C9JZ62
constant: false
name: TMEM91
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:641649
initial concentration: NaN
type: Species

metaM xolest2 hs e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
initial amount: NaN
constant: false
is: CHEBI:17002
name: cholesterol ester
is: SBO:0000247
has only substance units: false
type: Species

metaR FUMAC
fast: false
modifier: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.7.1.2
is described by: ECO:0000269
name: fumarylacetoacetase

metaM 3mob c
initial concentration: 1.0
boundary condition: false
name: 3-methyl-2-oxobutanoate
initial amount: NaN
constant: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
has only substance units: false
is: CHEBI:11851
is: HMDB00019
is: SBO:0000247
type: Species

metaR r0360
product: MODEL1310110003#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110003#
is: SBO:0000176
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
type: Reaction
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/6.2.1.16
reactant: MODEL1310110003#

metaR 2AMACHYD
reactant: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:500639 NOTES:SAB see PMID 500639: this reaction is spontaneous
reversible: false
kinetic law: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
name: 2-Aminoacrylate hydrolysis

http://identifiers.org/biomodels.db/MODEL1310110003#_1612a20a_0a97_4b90_927c_6ff4909e7328
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: A8K761
name: NDUFB10
is encoded by: hsa:4716
is: SBO:0000252
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_02bda0d8_39be_492b_aacf_e96d21f6ae91
is encoded by: hsa:29968
name: PSAT1
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: Q9Y617
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaR RE3565C
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
product: MODEL1310110003#
name: RE3565
type: Reaction
fast: false
reactant: MODEL1310110003#
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110003#

metaR DM pmtcoa LPAREN r RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pmtcoa
type: Reaction

metaM gsn c
is: CHEBI:16750
initial concentration: 1.0
name: Guanosine
is: HMDB00133
constant: false
is: C00387
is: SBO:0000247
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false

metaR GLYCtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
product: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110003#
name: glycerol transport
fast: false
reversible: true

metaR r2096
reactant: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110003#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110003#
type: Reaction
reversible: true

metaR EX g1p LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of alpha-D-glucose 1-phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_123811df_bb56_4521_aa30_49af99f1314e
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:83715
name: ESPN
has only substance units: false
is: B1AK53
type: Species
initial concentration: NaN
is: SBO:0000252

metaM CE2432 m
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
initial concentration: 1.0
constant: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
has only substance units: false
boundary condition: false
is: CHEBI:57795
is: SBO:0000247
initial amount: NaN
type: Species

metaM hdcea r
is: CHEBI:32372
initial concentration: 1.0
is: HMDB03229
is: SBO:0000247
constant: false
type: Species
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
initial amount: NaN
boundary condition: false
has only substance units: false
name: palmitoleate

metaM 3odcoa m
has only substance units: false
is: SBO:0000247
name: 3-Oxodecanoyl-CoA
constant: false
is: CHEBI:28528
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
type: Species
is: HMDB03939
initial amount: NaN

metaR EX HC01361 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Dihydroneopterin
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_dceadf6e_e0c9_4859_ab06_9ae75a6873f6
constant: false
initial amount: NaN
is: SBO:0000252
name: _W74642_1_c
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:W74642
initial concentration: NaN

metaM HC01434 c
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
name: oxalatosuccinate(3-)
is: CHEBI:58931
is: SBO:0000247
type: Species
initial amount: NaN

metaR RETNt
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
type: Reaction
kinetic law: MODEL1310110003#
is described by: ECO:0000000
name: retinoic acid transport
reversible: true
is: SBO:0000185
fast: false
reactant: MODEL1310110003#

metaR M16NTg
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
modifier: MODEL1310110003#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.143
type: Reaction
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

metaR ARACHDCOAtx
name: fatty acid intracellular transport
reactant: MODEL1310110003#
fast: false
reversible: true
kinetic law: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
product: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000

metaR r1254
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110003#
name: EC:6.2.1.3
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
reversible: false

metaR METtec
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
name: L-methionine transport via diffusion (extracellular to cytosol)
reactant: MODEL1310110003#
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110003#
is: SBO:0000185
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

metaR GLNS
product: MODEL1310110003#
is described by: ECO:0000254
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110003#
name: glutamine synthetase
modifier: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.1.1.15

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_39d45338_bf3b_42ef_8d24_e53453d3ecf0
has only substance units: false
is: P33316
initial concentration: NaN
name: DUT
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:1854
boundary condition: true

metaR H2Otly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
product: MODEL1310110003#
name: H2O transport, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110003#
type: Reaction
fast: false
kinetic law: MODEL1310110003#
reversible: true

metaM ctp c
is: C00063
constant: false
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
name: CTP
is: HMDB00082
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:37563
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_d8068897_aec8_4e73_ae2c_8968aedd018d
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: RPIA
boundary condition: true
is encoded by: hsa:22934
is: P49247

metaR r0587
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
product: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
fast: false
reversible: true
modifier: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM trdox m
is: CHEBI:18191
is: SBO:0000247
constant: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
name: Oxidized thioredoxin
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species

metaR r2093
kinetic law: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
is: SBO:0000185
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_1e85adf2_cd14_4a3f_9194_5f4301d46981
is: E7EQF2
is encoded by: hsa:54677
initial amount: NaN
has only substance units: false
name: CROT
boundary condition: true
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_ca841f13_2f28_4396_ab8e_d99873816464
name: SLC3A1
constant: false
has only substance units: false
type: Species
is encoded by: hsa:6519
initial amount: NaN
is: Q07837
is: SBO:0000252
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_00b5f3f1_47a0_4366_bd1e_310bb1507034
is encoded by: hsa:9583
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: Q9Y227
is: SBO:0000252
constant: false
type: Species
boundary condition: true
name: ENTPD4

metaM ksii core2 pre8 g
boundary condition: false
is: CHEBI:58053
type: Species
is: HMDB00175
is: SBO:0000247
initial amount: NaN
is: C00130
notes: FORMULA: C75H121N6O56SX CHARGE: -2
constant: false
name: keratan sulfate II biosynthesis, precursor 8
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_91dfad94_2af9_4cb7_8d6e_947e91357da0
name: IDI2
is encoded by: hsa:91734
is: SBO:0000252
type: Species
is: Q9BXS1
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_0a3443f7_4574_4e92_933e_b6a35b3ddf6e
boundary condition: true
name: PIP5K1B
has only substance units: false
is: O14986
is encoded by: hsa:8395
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

metaR S6T5g
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000

metaR ACACt2
reversible: true
type: Reaction
modifier: MODEL1310110003#
name: acetoacetate transport via proton symport
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
kinetic law: MODEL1310110003#
is: SBO:0000185
fast: false
is described by: ECO:0000269
product: MODEL1310110003#

metaR NH4tn
name: ammonia nuclear transport
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
is: SBO:0000185
product: MODEL1310110003#
fast: false
reversible: true
type: Reaction

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_9574fbfd_27eb_454f_a731_04c4aa975659
boundary condition: true
name: ACSS1
is: Q9NUB1
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:84532
type: Species

metaR TKT1
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
reversible: true
name: transketolase
reactant: MODEL1310110003#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.2.1.1
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.1 Confidence Level: 0 AUTHORS: NOTES:SMP Two reactions for transketolase: TKT1 and TKT2
fast: false
is described by: ECO:0000000

metaR FUMTSULtm
type: Reaction
is: SBO:0000185
reactant: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Fumarate:thiosulfate antiport, mitochondrial
fast: false
product: MODEL1310110003#
is described by: ECO:0000269
kinetic law: MODEL1310110003#
reversible: true

metaM Lkynr c
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
has only substance units: false
name: L-kynurenine
is: CHEBI:16946
is: HMDB00684
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_11071578_7d9c_4532_ad79_8658076223c3
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is: Q9H2H9
type: Species
is encoded by: hsa:81539
name: SLC38A1

metaM HC02204 e
constant: false
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
name: prostaglandin-b1
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:27624
boundary condition: false

metaR r2094
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
modifier: MODEL1310110003#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_8aace607_9ea6_41bd_95d9_a9dbdadfdad0
constant: false
boundary condition: true
initial amount: NaN
name: B3GNT7
is: SBO:0000252
type: Species
is encoded by: hsa:93010
initial concentration: NaN
has only substance units: false
is: Q8NFL0

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_8c772583_04b3_4250_bb01_5e4527028ac3
is encoded by: hsa:5831
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: A6NFM2
initial amount: NaN
type: Species
name: PYCR1
is: SBO:0000252

metaM gbside hs g
is: CHEBI:18259
constant: false
name: globoside
boundary condition: false
is: SBO:0000247
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_a2e13ff6_b9be_45bc_af4b_2ba0ecc5b6e4
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: GNS
is encoded by: hsa:2799
is: Q7Z3X3
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_57ce2cf8_bc6a_4e6c_b017_4593e21848d7
type: Species
initial amount: NaN
name: SYNJ1
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:8867
is: C9JFZ1
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_a12b53d2_231c_464d_86b7_1588fd25d465
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7991
type: Species
is: SBO:0000297
constant: false
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
boundary condition: true
initial amount: NaN

metaM udpglcur r
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: C00167
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
name: UDP-D-glucuronate
is: CHEBI:58052
is: HMDB00935
constant: false

metaR RE2998M
is: SBO:0000176
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110003#
product: MODEL1310110003#
name: RE2998
reversible: false
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
fast: false
is described by: ECO:0000000

metaM ppcoa m
initial concentration: 1.0
name: Propanoyl-CoA
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: CHEBI:57392
is: C00100
type: Species
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: HMDB01275
initial amount: NaN

metaR CLOHtex2
reversible: false
type: Reaction
product: MODEL1310110003#
is: SBO:0000185
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
name: chloride transport via hydroxide countertransport (2:1)
is described by: ECO:0000304

metaM duri c
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
constant: false
initial amount: NaN
is: C00526
is: CHEBI:16450
has only substance units: false
is: HMDB00012
type: Species
name: Deoxyuridine
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaR TMDPP
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.2.4
notes: GENE_ASSOCIATION: (1890.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.4.2.4 Confidence Level: 4 AUTHORS: PMID:7028324,PMID:718961,PMID:9693094 NOTES:
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000269
modifier: MODEL1310110003#
type: Reaction
name: thymidine phosphorylase
fast: false
reversible: true
is: SBO:0000176

metaM dc2coa m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
constant: false
name: trans-Dec-2-enoyl-CoA
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:61406
initial concentration: 1.0

metaR r1147
kinetic law: MODEL1310110003#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110003#
is described by: ECO:0000000
reversible: true
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false

metaR NDPK8n
is described by: ECO:0000304
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
type: Reaction
is: SBO:0000176
reversible: true
modifier: MODEL1310110003#
reactant: MODEL1310110003#
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear

http://identifiers.org/biomodels.db/MODEL1310110003#_e0e8971b_df40_41cd_83ff_cd45cea227b5
is encoded by: hsa:29922
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: Q9Y5B8
name: NME7
initial amount: NaN

metaM hs deg3 l
constant: false
type: Species
name: heparan sulfate, degradation product 3
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:16126

http://identifiers.org/biomodels.db/MODEL1310110003#_c79d36a7_5021_43d7_9db1_e96a2b10fab1
boundary condition: true
constant: false
is: Q9GZR5
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6785
has only substance units: false
type: Species
name: ELOVL4

metaM pan4p m
constant: false
name: pantetheine 4'-phosphate(2-)
is: SBO:0000247
is: HMDB01416
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:47942
boundary condition: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
initial amount: NaN

metaR HSD17B9r
name: 17-beta-hydroxysteroid dehydrogenase (type 7)
is described by: ECO:0000304
product: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.62
modifier: MODEL1310110003#
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (51478.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 2 AUTHORS: PMID:14643063 NOTES:see PMID: 14643063 inferred use of O2 for oxidation - biochemical details have not yet been experimentally elucidated NJ

metaR ABTD
product: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
type: Reaction
name: L-arabinitol 4-dehydrogenase
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
reversible: true

metaR r2091
product: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reactant: MODEL1310110003#

metaM lnlc e
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
initial amount: NaN
constant: false
is: CHEBI:30245
is: HMDB00673
initial concentration: 1.0
name: linoleate
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_effa4349_2573_4bf2_9653_e7deb4040820
name: PLA2G7
is: SBO:0000252
is encoded by: hsa:7941
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is: Q13093
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_20cc7f78_d0b2_4ce2_a7ca_5362a9c9bfaa
constant: false
has only substance units: false
name: B3GNT1
is: O43505
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:11041
initial amount: NaN

metaR r0791
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.107
name: trans-Hex-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
is: SBO:0000176
reversible: true
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3028.1) or (3295.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
fast: false

metaR r2090
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
is: SBO:0000185
fast: false

metaR PSERT
is version of: http://identifiers.org/ec-code/2.6.1.52
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
is: SBO:0000176
type: Reaction
name: phosphoserine transaminase
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: false
modifier: MODEL1310110003#
fast: false

metaM idp c
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB03335
initial amount: NaN
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: CHEBI:58280
name: IDP(3-)
has only substance units: false

metaR r0364
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110003#_49bb403f_b1a4_4e6d_8bba_09acc714a134
name: NDUFA2
constant: false
is: O43678
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4695

metaR NH4tp
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reactant: MODEL1310110003#
type: Reaction
reversible: true
name: ammonia peroxisomal transport

metaR CSNt
is: SBO:0000185
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
type: Reaction
reactant: MODEL1310110003#
fast: false
name: cytosine transport via facilated diffusion
kinetic law: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_e7e65733_3018_4b11_a12c_97c1d8ad4a5e
initial concentration: NaN
is encoded by: hsa:79695
constant: false
name: GALNT12
type: Species
has only substance units: false
is: Q8IXK2
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM urate c
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00289
boundary condition: false
name: Urate
is: CHEBI:17775
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H4N4O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00310 EHMN_ABBREVIATION: C00366
is: C00366
type: Species

metaR GLCtg
name: glucose transport, Golgi apparatus
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (6513.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:15384581 NOTES:NCD
kinetic law: MODEL1310110003#
is: SBO:0000185
reversible: true
modifier: MODEL1310110003#
type: Reaction
fast: false
reactant: MODEL1310110003#
is described by: ECO:0000269

metaR r1318
is described by: ECO:0000000
product: MODEL1310110003#
kinetic law: MODEL1310110003#
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
reactant: MODEL1310110003#
type: Reaction
fast: false
is: SBO:0000185

metaR 3AIB Dtm
kinetic law: MODEL1310110003#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000134
name: transport of 3aib_D into mitochondria

http://identifiers.org/biomodels.db/MODEL1310110003#_62e84025_d47d_46b2_8ab8_7c71e7f81412
type: Species
is encoded by: hsa:124454
initial amount: NaN
name: EARS2
initial concentration: NaN
constant: false
boundary condition: true
is: Q5JPH6
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_fa82f15f_a8bf_4cbe_b2ae_2d8979ad7922
constant: false
name: _AI378339_1_m
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:AI378339

http://identifiers.org/biomodels.db/MODEL1310110003#_480f2d6f_3ec0_4b68_a907_d506f179b8cd
initial amount: NaN
is encoded by: hsa:3177
boundary condition: true
has only substance units: false
is: Q14542
is: SBO:0000252
initial concentration: NaN
name: SLC29A2
type: Species
constant: false

metaM duri e
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16450
is: C00526
constant: false
boundary condition: false
type: Species
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
name: Deoxyuridine
initial amount: NaN
has only substance units: false
is: HMDB00012

metaR r2092
reactant: MODEL1310110003#
reversible: true
product: MODEL1310110003#
is described by: ECO:0000000
kinetic law: MODEL1310110003#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110003#
fast: false

metaM CE2421 m
boundary condition: false
constant: false
initial amount: NaN
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
is: SBO:0000247
has only substance units: false
name: (3S)-3-hydroxylinoleoyl-CoA
is: CHEBI:30623
initial concentration: 1.0
is: HMDB02329
type: Species

metaR r0365
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
modifier: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.72
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_cef980db_82a1_41d2_ab5e_4dac13d4a591
initial amount: NaN
is encoded by: hsa:2530
constant: false
is: A8K8P8
has only substance units: false
name: FUT8
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_8e68d0a9_32ec_4984_898e_d6b006aa4c88
is: O15382
is: SBO:0000252
has only substance units: false
is encoded by: hsa:587
constant: false
name: BCAT2
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaR MAL Lte
is described by: ECO:0000134
type: Reaction
fast: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
name: Transport of L-malate
is: SBO:0000185

metaR KCCt
reactant: MODEL1310110003#
is: SBO:0000185
modifier: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (10723.1) or (57468.1) or (9990.1) or (6560.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:12739168,PMID:8663127 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110003#
fast: false
product: MODEL1310110003#
is described by: ECO:0000269
name: K+-Cl- cotransport

metaM ocdcea r
type: Species
initial amount: NaN
initial concentration: 1.0
name: octadecenoate (n-C18:1)
is: SBO:0000247
is: C00712
is: HMDB00207
constant: false
is: CHEBI:0
notes: FORMULA: C18H33O2 CHARGE: -1
has only substance units: false
boundary condition: false

metaM 4abut n
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
is: C00334
is: SBO:0000247
name: 4-Aminobutanoate
type: Species
notes: FORMULA: C4H9NO2 CHARGE: 0
initial amount: NaN
is: HMDB00112

http://identifiers.org/biomodels.db/MODEL1310110003#_88a3fd0d_7237_42d0_a28c_afa4bc4fd3fb
constant: false
is: SBO:0000252
initial concentration: NaN
name: HSD3B2
initial amount: NaN
has only substance units: false
is encoded by: hsa:3284
is: P26439
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_0d9409ef_2d3d_4182_8b45_85a072e69bab
is encoded by: hsa:4830
has part: P15531
is: SBO:0000297
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
has part: P22392
is encoded by: hsa:4831
name: NME1:NME2

metaM L2aadp m
constant: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
boundary condition: false
is: SBO:0000247
is: CHEBI:58672
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: L-2-aminoadipate(1-)
type: Species
is: HMDB00510

metaM n2m2nm l
is: CHEBI:57312
notes: FORMULA: C58H97N5O41 CHARGE: 0
is: HMDB01356
name: n2m2nmasn (w/o peptide linkage)
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false

metaR LCTStg
is: SBO:0000185
name: lactose transport from Golgi to extracellular (via vesicle)
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:this reaciton is only found in lactating mammary cells NCD
kinetic law: MODEL1310110003#
fast: false
type: Reaction
reversible: false
is described by: ECO:0000000
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_38e87146_084b_4be6_aedf_54f4c3826018
has only substance units: false
is encoded by: hsa:AA419122
initial concentration: NaN
name: _AA419122_1_c
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true

metaR GGH 10FTHF6GLUe
kinetic law: MODEL1310110003#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_610815f4_ad76_496d_bb41_43a8da98a558
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:771
constant: false
has only substance units: false
is: O43570
boundary condition: true
name: CA12

http://identifiers.org/biomodels.db/MODEL1310110003#_6e29e26c_2cb8_4464_a6fe_c62182f20829
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4645
type: Species
name: MYO5B
constant: false
is: Q9H6Y6
has only substance units: false
boundary condition: true
initial amount: NaN

metaM 1pipdn2c x
is: CHEBI:16187
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB01084
has only substance units: false
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092
boundary condition: false
name: 1-piperideine-2-carboxylate
constant: false

metaM clpndcoa x
is: C16166
boundary condition: false
type: Species
constant: false
name: clupanodonyl CoA
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: SBO:0000247
is: HMDB06267
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205476
initial concentration: 1.0

metaM lnlc c
initial amount: NaN
is: CHEBI:30245
name: linoleate
initial concentration: 1.0
constant: false
is: HMDB00673
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
boundary condition: false

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaM pnto R c
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial concentration: 1.0
is: CHEBI:7916
name: (R)-Pantothenate
constant: false
is: HMDB00210
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_e61223d3_5713_49af_a96f_a71854e25abb
name: SLCO4A1
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q96BD0
initial concentration: NaN
constant: false
is encoded by: hsa:28231
type: Species
is: SBO:0000252

metaR BILIRUBtr
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000
product: MODEL1310110003#
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110003#
reversible: true
is: SBO:0000185
type: Reaction
fast: false

metaM ppi e
name: Diphosphate
is: CHEBI:33019
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00250
type: Species
is: C00013

http://identifiers.org/biomodels.db/MODEL1310110003#_cceee7ae_f868_41bc_85d8_5e794f0da1dc
boundary condition: true
type: Species
is encoded by: hsa:AA177072
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: _AA177072_1_c
initial concentration: NaN
constant: false

metaM idp e
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB03335
boundary condition: false
initial amount: NaN
is: CHEBI:58280
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
name: IDP(3-)

http://identifiers.org/biomodels.db/MODEL1310110003#_474c7781_8314_4d98_89d7_f84e57d34778
has only substance units: false
is encoded by: hsa:3073
is: SBO:0000252
is: P06865
name: HEXA
type: Species
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

metaM mlthf m
initial amount: NaN
is: HMDB01533
boundary condition: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
type: Species
is: SBO:0000247
is: CHEBI:15636
initial concentration: 1.0
has only substance units: false
constant: false
is: C00143
name: 5,10-Methylenetetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110003#_9c08d848_e8da_47bc_a0df_6aa25b059dd6
is: P37837
name: TALDO1
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:6888
is: SBO:0000252

metaR ALAGLYexR
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is: SBO:0000185
name: L-alanine/glycine reversible exchange
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000304
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true
type: Reaction
fast: false

metaR RE1691M
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.1.1
kinetic law: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (7263.1) SUBSYSTEM: Miscellaneous EC Number: 2.8.1.1 Confidence Level: 0 AUTHORS: PMID:1953758,PMID:9070219 NOTES:
name: RE1691
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_ddc6af36_1f0a_4c07_9ab4_02ff10a4ba5a
is: Q11201
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6482
boundary condition: true
name: ST3GAL1

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR G14T8g
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaM ptth c
is: HMDB03426
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:16753
name: pantetheine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_450d9416_c49a_4b55_8dac_0b7bbcec7140
initial amount: NaN
constant: false
is encoded by: hsa:593
boundary condition: true
has only substance units: false
is: SBO:0000252
is: B4DP47
name: BCKDHA
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_1103589d_ead4_45cb_938d_e79dae0e2f3a
type: Species
is: E2QC23
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:23464
name: GCAT
has only substance units: false

metaR r0639
reactant: MODEL1310110003#
is: SBO:0000176
type: Reaction
product: MODEL1310110003#
reversible: false
kinetic law: MODEL1310110003#
name: Lauroyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_96a97235_9159_44d9_9d5d_8cc10a95e194
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
is: Q92781
is: SBO:0000252
type: Species
name: RDH5
is encoded by: hsa:5959

metaM andrstandn r
initial concentration: 1.0
is: CHEBI:15994
is: SBO:0000247
boundary condition: false
constant: false
name: 5alpha-androstane-3,17-dione
has only substance units: false
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
initial amount: NaN
is: HMDB00899

metaR HYXNt
reactant: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
is described by: ECO:0000269
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
reversible: true
kinetic law: MODEL1310110003#
name: Hypoxanthine transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_d5c4479c_2eb4_4192_9775_c2971268a13c
is encoded by: hsa:1351
name: COX8A
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q53XN1
has only substance units: false
initial amount: NaN
constant: false

metaM leuktrF4 e
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
name: leukotriene F4
is: HMDB06465
has only substance units: false
is: CHEBI:27491
constant: false
initial amount: NaN

metaM ddsmsterol r
is: HMDB03896
constant: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:27910
has only substance units: false
initial amount: NaN
name: 7-dehydrodesmosterol

metaR PRO Dtde
reversible: true
reactant: MODEL1310110003#
name: D-proline transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false

metaM 4ppan c
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: C03492
has only substance units: false
boundary condition: false
is: HMDB01016
constant: false
is: CHEBI:10986
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
name: D-4'-Phosphopantothenate
type: Species

metaR SPODM
is described by: ECO:0000269
product: MODEL1310110003#
reversible: false
name: superoxide dismutase
type: Reaction
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
reactant: MODEL1310110003#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.15.1.1
modifier: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#

metaM gal c
is: CHEBI:0
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0
boundary condition: false
constant: false
type: Species
is: HMDB00143
name: D-Galactose
initial amount: NaN
is: C00124

http://identifiers.org/biomodels.db/MODEL1310110003#_559f7be5_0255_46df_b574_7601e92814c4
initial concentration: NaN
is: B4DX62
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ST3GAL3
constant: false
is encoded by: hsa:6487
boundary condition: true
type: Species

metaM ctp e
is: HMDB00082
is: SBO:0000247
has only substance units: false
boundary condition: false
name: CTP(4-)
initial amount: NaN
type: Species
is: CHEBI:37563
constant: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
initial concentration: 1.0

metaR INSTt2r
kinetic law: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
product: MODEL1310110003#
reactant: MODEL1310110003#
name: inositol transport in via proton symport
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
reversible: true
modifier: MODEL1310110003#

metaR r0655
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.2
reactant: MODEL1310110003#
is: SBO:0000176
modifier: MODEL1310110003#

metaM crm hs r
is: CHEBI:52639
initial amount: NaN
constant: false
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
name: N-acylsphingosine
initial concentration: 1.0

metaR C226COAtx
name: fatty acid intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
fast: false
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_cfad7ef7_84cf_4bb3_910b_72823e03b267
name: SLC24A2
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: Q9UI40
is: SBO:0000252
is encoded by: hsa:25769
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_08a78aa7_2672_4828_9867_2f6eb1a5b564
initial amount: NaN
name: SARDH
is: A8K596
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:1757

metaR RE0830N
reversible: true
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
kinetic law: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
modifier: MODEL1310110003#
name: RE0830
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
reactant: MODEL1310110003#
type: Reaction
is: SBO:0000176

metaR Htx
fast: false
product: MODEL1310110003#
is described by: ECO:0000000
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
name: H transporter, peroxisome
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ

http://identifiers.org/biomodels.db/MODEL1310110003#_f404646e_4b0b_472c_b99f_6f7db07d386c
is: SBO:0000252
constant: false
is: Q96PD7
type: Species
has only substance units: false
is encoded by: hsa:84649
initial concentration: NaN
initial amount: NaN
name: DGAT2
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_5c5cfa1f_1a36_4bd5_8aee_77718a34af89
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: _100128062_1_m
type: Species
constant: false
is encoded by: hsa:100128062
boundary condition: true

metaR r1546
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_36a5d81d_641b_4e00_b124_dbea291b7fa2
has only substance units: false
type: Species
initial amount: NaN
name: ACSL6
constant: false
initial concentration: NaN
is encoded by: hsa:23305
is: B2RB13
boundary condition: true
is: SBO:0000252

metaR TMDS
fast: false
kinetic law: MODEL1310110003#
name: thymidylate synthase
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.1.1.45
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7298.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.1.1.45 Confidence Level: 4 AUTHORS: PMID:14967037,PMID:2243092 NOTES:
type: Reaction
product: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000176

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaR RE3243R
name: RE3243
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790,PMID:11567032,PMID:2114179 NOTES:
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
product: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true

metaR AKR1D
reactant: MODEL1310110003#
reversible: false
fast: false
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.1.3
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)

metaM nad r
type: Species
constant: false
is: CHEBI:57540
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
initial amount: NaN
is: HMDB00902
name: NAD(1-)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_4acad747_e08d_44c7_873c_7c4a826da012
is: P11182
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:1629
has only substance units: false
initial concentration: NaN
name: DBT
initial amount: NaN
constant: false

metaM HC01602 c
is: CHEBI:57454
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
boundary condition: false
is: C00234
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
name: 10-Formyltetrahydrofolate

metaM thp2c x
type: Species
is: HMDB12130
constant: false
initial amount: NaN
is: CHEBI:16987
name: 1-piperideine-6-carboxylate
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_615b0425_0246_471f_869a_3552e2f3cd02
initial concentration: NaN
name: NDUFA7
is: SBO:0000252
is: Q6FG42
initial amount: NaN
constant: false
is encoded by: hsa:4701
boundary condition: true
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_2803f07e_5a6f_42ff_b777_6e1726467dce
type: Species
constant: false
name: LDHD
boundary condition: true
is encoded by: hsa:197257
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_d678d3b7_a6e2_4240_bf6d_3c73edcfd9dd
initial amount: NaN
type: Species
is encoded by: hsa:2629
initial concentration: NaN
has only substance units: false
constant: false
name: GBA
boundary condition: true
is: B7Z6S9
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_c995c6c1_5cc4_4936_b23d_e2321f7ac49b
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:3423
initial concentration: NaN
type: Species
initial amount: NaN
is: P22304
name: IDS

http://identifiers.org/biomodels.db/MODEL1310110003#_3397d5cf_d600_44ba_87be_5c7b846299b4
name: SLC8A3
has only substance units: false
is: P57103
initial amount: NaN
constant: false
is encoded by: hsa:6547
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252

metaR r0539
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
modifier: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.1.34
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
fast: false
reversible: true

metaR A MANASEly
modifier: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
reversible: false
name: alpha-mannosidase, lysosomal
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.2.1.24
fast: false
is: SBO:0000176
kinetic law: MODEL1310110003#

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR PE HSter
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
type: Reaction
reversible: true
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
fast: false
name: phosphatidylethanolamine scramblase

metaR CDIPTr
type: Reaction
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
is: SBO:0000176
modifier: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
name: phosphatidylinositol synthase (Homo sapiens)
reversible: true
product: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.8.11
is described by: ECO:0000000

metaR ACNACNGALGBSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is: SBO:0000185
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
is described by: ECO:0000000
name: acnacngalgbside hs intracellular transport
kinetic law: MODEL1310110003#
reversible: true
fast: false

metaR CYTK10n
name: cytidylate kinase (CMP,dGTP),nuclear
product: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
modifier: MODEL1310110003#
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_62c95647_cfba_4bc5_9417_4cf04e1fb0a6
is: Q9H6R3
name: ACSS3
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:79611
constant: false
boundary condition: true
initial amount: NaN

metaR r1547
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110003#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_70c8dcca_2a30_4e8c_8c5e_f05b71bccd18
is: O14732
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
name: IMPA2
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:3613

metaR LEUt5m
name: leucine mitochondrial transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
product: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
is: SBO:0000185
reversible: true

metaR TALA
product: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true
fast: false
is described by: ECO:0000000
name: transaldolase
reactant: MODEL1310110003#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
is version of: http://identifiers.org/ec-code/2.2.1.2

metaR FAOXC200180m
modifier: MODEL1310110003#
reversible: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
kinetic law: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
product: MODEL1310110003#
is: SBO:0000176

metaR r0994
reversible: true
type: Reaction
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
name: Facilitated diffusion
fast: false
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_3b689f62_04c3_4be6_a6d2_5798f59896ed
initial amount: NaN
is encoded by: hsa:H77542
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: _H77542_1_c
type: Species
boundary condition: true

metaR CHOLD2m
reversible: false
kinetic law: MODEL1310110003#
name: choline dehydrogenase (FAD acceptor), mitochondrial
modifier: MODEL1310110003#
is described by: ECO:0000269
product: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.99.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
fast: false
type: Reaction

metaR RE0383C
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000000
modifier: MODEL1310110003#
type: Reaction
name: RE0383
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
is: SBO:0000176

metaR r0881
is described by: ECO:0000000
type: Reaction
name: Active transport
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
kinetic law: MODEL1310110003#
fast: false
is: SBO:0000185
reversible: false

metaR r2411
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
reactant: MODEL1310110003#
type: Reaction
reversible: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

metaR UDPGALtg
is described by: ECO:0000269
reactant: MODEL1310110003#
fast: false
name: UDP-Gal Golgi transport via CMP antiport
type: Reaction
product: MODEL1310110003#
is: SBO:0000185
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
reversible: true

metaR NICRNS
name: NICRNS
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:no gene or enzyme name known (in kegg) but reaction has to take place. IT
product: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000

metaR r1548
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110003#
is described by: ECO:0000000
kinetic law: MODEL1310110003#
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_383dd82b_95b4_49b9_a3f4_a6cc6ebe99a3
is: SBO:0000252
constant: false
is encoded by: hsa:126328
is: C9JT23
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: NDUFA11

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_d91728cf_2231_47d2_8e2d_9c8f0350dc59
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:275
initial amount: NaN
name: AMT
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P48728

metaR NDPK7n
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110003#
is described by: ECO:0000304
is: SBO:0000176
reactant: MODEL1310110003#
name: nucleoside-diphosphate kinase (ATP:dCDP), nuclear
product: MODEL1310110003#
fast: false
type: Reaction
modifier: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus

http://identifiers.org/biomodels.db/MODEL1310110003#_46b83510_ff92_4242_8ae6_e134b018afca
has only substance units: false
is: Q9NVE7
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:55229
initial amount: NaN
type: Species
is: SBO:0000252
name: PANK4

metaR IPDPtx
kinetic law: MODEL1310110003#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
name: Isopentenyl diphosphate transport (peroxisome)
product: MODEL1310110003#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110003#_0a76b5f9_f3f5_4829_9eb0_4f88ae34b86f
type: Species
has only substance units: false
is encoded by: hsa:2747
is: SBO:0000252
is: P49448
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
name: GLUD2

http://identifiers.org/biomodels.db/MODEL1310110003#_3bd01d1a_2998_4c87_b25d_b006a1cb670a
initial concentration: NaN
is: Q92185
constant: false
boundary condition: true
is encoded by: hsa:6489
is: SBO:0000252
has only substance units: false
name: ST8SIA1
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_0c8213b0_301a_43dd_87f8_a56b49d2a90d
is: SBO:0000252
is: Q86VV3
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: ENTPD1
type: Species
is encoded by: hsa:953

http://identifiers.org/biomodels.db/MODEL1310110003#_978f3498_9f68_4e9f_8698_231e58225f71
initial amount: NaN
type: Species
initial concentration: NaN
name: _AF080579_1_c
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:AF080579

metaM nadh m
type: Species
constant: false
is: CHEBI:57945
initial concentration: 1.0
is: SBO:0000247
is: C00004
initial amount: NaN
is: HMDB01487
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
has only substance units: false
name: Nicotinamide adenine dinucleotide - reduced

http://identifiers.org/biomodels.db/MODEL1310110003#_320f2ab4_b0eb_4a8c_89ae_72199c88bbb7
name: ST3GAL3
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6487
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false

metaR r1549
is: SBO:0000185
reactant: MODEL1310110003#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110003#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_b673e2dc_cef1_42f7_a652_afb0691e9657
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P38571
boundary condition: true
is encoded by: hsa:3988
name: LIPA
type: Species

metaR S6T6g
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
product: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110003#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110003#

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_55616fa6_e873_40f7_a5d3_939a28fe0633
constant: false
is encoded by: hsa:55577
is: Q9UJ70
name: NAGK
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species

metaR S6TASE3ly
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
modifier: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110003#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
fast: false
type: Reaction

metaR DUMPtn
kinetic law: MODEL1310110003#
fast: false
product: MODEL1310110003#
type: Reaction
name: dUMP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110003#
is: SBO:0000185
reversible: true
is described by: ECO:0000000

metaM 4izp c
is: SBO:0000247
is: HMDB01014
boundary condition: false
is: CHEBI:57255
constant: false
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C6H7N2O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01157 EHMN_ABBREVIATION: C03680
initial concentration: 1.0
name: 4-Imidazolone-5-propanoate

http://identifiers.org/biomodels.db/MODEL1310110003#_3776e2c9_77af_47b1_b68e_8da928e7a506
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: GSR
type: Species
constant: false
is encoded by: hsa:2936
has only substance units: false
is: P00390

metaM didp n
constant: false
is: SBO:0000247
is: CHEBI:28823
name: dIDP
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB03536
initial amount: NaN
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_ad3c707d_8bde_4fe3_95c2_b72325370e33
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: P00441
initial concentration: NaN
is encoded by: hsa:6647
is: SBO:0000252
name: SOD1

http://identifiers.org/biomodels.db/MODEL1310110003#_7e638894_ccf9_44a7_b407_0090c7c73ba3
name: NME1
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is: P15531
boundary condition: true
is encoded by: hsa:4830

metaM HC00229 e
constant: false
is: CHEBI:28189
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: Isomaltose

http://identifiers.org/biomodels.db/MODEL1310110003#_24654bfb_6636_4497_99f5_caf91667fe88
is: SBO:0000252
constant: false
initial concentration: NaN
is: E9PB82
boundary condition: true
name: HSD17B4
is encoded by: hsa:3295
initial amount: NaN
type: Species
has only substance units: false

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM trdrd m
constant: false
has only substance units: false
name: Reduced thioredoxin
initial concentration: 1.0
boundary condition: false
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
type: Species
is: SBO:0000247
is: CHEBI:15967
initial amount: NaN

metaR r0908
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
product: MODEL1310110003#
is: SBO:0000185
fast: false
type: Reaction
name: Postulated transport reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:

metaR STRDNCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110003#
name: fatty acid transport via diffusion
is: SBO:0000185
reactant: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
fast: false

metaR CYTK9n
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reactant: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110003#
name: cytidylate kinase (CMP,dCTP),nuclear
product: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
fast: false

metaM nadh r
name: NADH(2-)
type: Species
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
is: SBO:0000247
is: HMDB01487
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:57945
constant: false
initial amount: NaN

metaR FADtru
reversible: false
fast: false
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
name: FAD transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185

metaR r0999
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: true
reactant: MODEL1310110003#
product: MODEL1310110003#
name: Facilitated diffusion
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

metaM ile L e
is: HMDB00172
name: L-isoleucine
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:17191
initial concentration: 1.0
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247

metaR LPS3
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.1.23
modifier: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110003#
name: lipase
is: SBO:0000176
kinetic law: MODEL1310110003#
type: Reaction
fast: false

metaM 34hpp e
initial amount: NaN
is: HMDB00707
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:36242
type: Species
boundary condition: false
initial concentration: 1.0
name: 3-(4-hydroxyphenyl)pyruvate
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1

metaM 7dhf e
is: HMDB06559
initial concentration: 1.0
constant: false
name: heptaglutamyl folate (DHF)
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110003#_d65ac932_27d6_4770_b434_6913423b6381
name: GALE
initial amount: NaN
is encoded by: hsa:2582
has only substance units: false
is: SBO:0000252
is: Q14376
constant: false
boundary condition: true
initial concentration: NaN
type: Species

metaR r1292
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
reactant: MODEL1310110003#
fast: false
name: Postulated transport reaction

metaM k c
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
constant: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00586
is: C00238
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
name: potassium
is: CHEBI:29103

http://identifiers.org/biomodels.db/MODEL1310110003#_47b9535b_db8b_48bf_b962_ddd08f8c2a4b
initial amount: NaN
constant: false
is encoded by: hsa:2348
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
name: FOLR1
boundary condition: true

metaM mi134p c
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2-,3+,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01243
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01143
initial amount: NaN
is: SBO:0000247
is: CHEBI:58414
name: 1D-myo-inositol 1,3,4-trisphosphate(6-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_4149cdec_04e6_402f_adb2_7a9073106461
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q6AI14
name: SLC9A4
has only substance units: false
constant: false
boundary condition: true
type: Species
is encoded by: hsa:389015

metaM andrstndn r
initial concentration: 1.0
is: CHEBI:16422
notes: FORMULA: C19H26O2 CHARGE: 0 INCHI: InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00280
constant: false
is: HMDB00053
name: androst-4-ene-3,17-dione
type: Species
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false

metaR BTNt4i
reactant: MODEL1310110003#
reversible: false
fast: false
is: SBO:0000185
kinetic law: MODEL1310110003#
is described by: ECO:0000269
name: Biotin uptake (antiport)
type: Reaction
product: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110003#_0250eaad_0278_4b2d_b483_947cce0c3794
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: Q13825
is encoded by: hsa:549
name: AUH
boundary condition: true
initial concentration: NaN
type: Species

metaR r0909
kinetic law: MODEL1310110003#
reversible: true
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_12ddb3a3_1d65_44b0_8fc9_d343c7e3f226
type: Species
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:4712
boundary condition: true
initial amount: NaN
is: O95139
name: NDUFB6
initial concentration: NaN

metaM prostgf2 e
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: prostaglandin F2alpha(1-)
is: SBO:0000247
is: CHEBI:57404
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: HMDB01139
initial concentration: 1.0

metaR PHACCOAGLNAC
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
product: MODEL1310110003#

metaR r0998
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
name: Facilitated diffusion
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110003#

metaR RE2814M
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is described by: ECO:0000000
name: RE2814
reversible: true
type: Reaction
reactant: MODEL1310110003#
fast: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_df431220_074b_4c4b_b960_1319d6719c8a
constant: false
is encoded by: hsa:2639
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: GCDH

metaR r1291
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110003#
name: Postulated transport reaction
reversible: true
fast: false

metaR r1620
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110003#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false

metaR LPS2
is described by: ECO:0000000
fast: false
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.1.34
is: SBO:0000176
notes: GENE_ASSOCIATION: (4023.1) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.3 Confidence Level: 4 AUTHORS: PMID:1969408 NOTES:FULLR corresponds to acyl/R groups in texts. NJ
reversible: false
name: lipase
modifier: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#

metaM 4abut m
constant: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:16865
is: SBO:0000247
has only substance units: false
is: HMDB00112
is: C00334
initial concentration: 1.0
name: 4-Aminobutanoate
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334

metaM m6masnB2 g
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:57312
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: HMDB01356
notes: FORMULA: C58H97N2O45X CHARGE: 0
initial concentration: 1.0
constant: false

metaR S2TASE1ly
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.6.13
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: iduronate-2-sulfatase, lysosomal
reversible: false

metaM dgtp e
name: dGTP
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16497
is: HMDB01440
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial amount: NaN
type: Species

metaR D3AIBTm
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
is: SBO:0000176
type: Reaction
product: MODEL1310110003#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM
fast: false
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_451d2bc2_3c65_41c9_a725_1fe7a891bd5b
name: BPNT1
is encoded by: hsa:10380
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
is: O95861
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_9d03afc9_2dfe_4036_9901_2cc41ad2351f
is encoded by: hsa:2348
initial amount: NaN
constant: false
is: SBO:0000252
name: FOLR1
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true

metaM pail45p hs n
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:28910
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
initial amount: NaN
name: phosphatidylinositol 4,5-bisphosphate

metaR RE1810M
is: SBO:0000176
type: Reaction
name: RE1810
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
reactant: MODEL1310110003#
product: MODEL1310110003#

metaR PMANM
product: MODEL1310110003#
reversible: true
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/5.4.2.2
is: SBO:0000176
name: phosphomannomutase
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/5.4.2.8
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:

metaM pap g
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
name: adenosine 3',5'-bismonophosphate(4-)
is: CHEBI:58343
boundary condition: false
is: HMDB00061
type: Species
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_48be05ac_93a7_4e48_9fc9_e7f2da9dd781
is encoded by: hsa:1491
constant: false
type: Species
initial amount: NaN
is: P32929
has only substance units: false
is: SBO:0000252
name: CTH
boundary condition: true
initial concentration: NaN

metaM HC01401 m
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
name: (S)-3-Hydroxydodecanoyl-CoA
has only substance units: false
is: CHEBI:27668
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_bf6f57cd_d317_48a2_9b35_dea8699c0937
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:7296
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: TXNRD1
has only substance units: false
is: Q16881

metaM hs l
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: CHEBI:28815
notes: FORMULA: C79H114N5O102S12 CHARGE: -13
boundary condition: false
initial amount: NaN
name: heparan sulfate, free chain

http://identifiers.org/biomodels.db/MODEL1310110003#_371b93e3_bd2a_4817_8076_a94cfc86660d
is encoded by: hsa:2531
name: KDSR
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: Q06136
has only substance units: false
initial amount: NaN
constant: false

metaM pmtcoa x
notes: FORMULA: C37H62N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00150 EHMN_ABBREVIATION: C00154
initial amount: NaN
is: C00154
boundary condition: false
is: HMDB01338
initial concentration: 1.0
constant: false
has only substance units: false
name: Palmitoyl-CoA (n-C16:0CoA)
is: CHEBI:57379
is: SBO:0000247
type: Species

metaM nad x
is: HMDB00902
boundary condition: false
is: SBO:0000247
is: C00003
has only substance units: false
name: Nicotinamide adenine dinucleotide
type: Species
constant: false
is: CHEBI:57540
is: http://identifiers.org/pubchem.compound/3305
initial amount: NaN
initial concentration: 1.0

metaR r1621
modifier: MODEL1310110003#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
product: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_d1c876b8_f0ff_46b0_9596_c73e1209356f
constant: false
boundary condition: true
has only substance units: false
type: Species
is: P05091
name: ALDH2
is: SBO:0000252
is encoded by: hsa:217
initial amount: NaN
initial concentration: NaN

metaM ile L c
is: HMDB00172
constant: false
is: CHEBI:17191
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
name: L-isoleucine

metaM k e
name: potassium
is: SBO:0000247
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:29103
boundary condition: false
is: HMDB00586
is: C00238
type: Species
initial amount: NaN

metaM hs deg17 l
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:21338
has only substance units: false
initial amount: NaN
is: HMDB02704
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
name: heparan sulfate, degradation product 17
constant: false
type: Species

metaR r1544
fast: false
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_14aa548f_01be_40e9_ba8b_707dd0d7af30
is: P22392
name: NME2
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4831
constant: false
boundary condition: true

metaM ac m
is: HMDB00042
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
name: acetate
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
is: CHEBI:30089
is: SBO:0000247

metaR UMPK3n
type: Reaction
name: UMP kinase (UTP),nuclear
fast: false
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reversible: true

metaM pail45p hs m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:28910
constant: false
is: SBO:0000247
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
type: Species
has only substance units: false
name: phosphatidylinositol 4,5-bisphosphate

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaM dgtp c
is: HMDB01440
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
type: Species
name: dGTP
initial amount: NaN
is: CHEBI:16497
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C00286
initial concentration: 1.0

metaM 34hpp c
has only substance units: false
initial amount: NaN
name: 3-(4-hydroxyphenyl)pyruvate
boundary condition: false
is: CHEBI:36242
constant: false
is: SBO:0000247
type: Species
is: HMDB00707
initial concentration: 1.0
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179

metaM prostgf2 c
boundary condition: false
name: prostaglandin F2alpha(1-)
initial amount: NaN
constant: false
is: CHEBI:57404
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB01139

metaR ACHEe
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.1.7
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
type: Reaction
modifier: MODEL1310110003#
name: Acetylcholinesterase
reactant: MODEL1310110003#
reversible: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false

metaM 4nph e
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57917
is: HMDB01232
constant: false
is: SBO:0000247
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial concentration: 1.0
type: Species
name: 4-nitrophenolate

metaR S6T10g
product: MODEL1310110003#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110003#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction

metaR MM6B2g
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
kinetic law: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.2.1.113
type: Reaction
reactant: MODEL1310110003#
modifier: MODEL1310110003#
fast: false

metaR r1622
is described by: ECO:0000000
reactant: MODEL1310110003#
reversible: true
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110003#
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#

metaM hs deg19 l
has only substance units: false
is: SBO:0000247
name: heparan sulfate, degradation product 19
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C43H67N2O42S2 CHARGE: -3
boundary condition: false
is: CHEBI:15699
type: Species
is: HMDB00719

metaM xol7ah2al m
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
is: CHEBI:27428
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
initial concentration: 1.0
is: SBO:0000247
is: HMDB06894
constant: false
has only substance units: false
initial amount: NaN
type: Species

metaR PItg
reactant: MODEL1310110003#
is: SBO:0000185
reversible: false
type: Reaction
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: phosphate transport, Golgi apparatus
kinetic law: MODEL1310110003#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_12672956_ac94_4a79_b4a7_bec33dadb34a
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:6240
constant: false
name: RRM1
is: P23921
initial amount: NaN

metaR G14T6g
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
is described by: ECO:0000000
kinetic law: MODEL1310110003#

metaR GLRASE
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 1.1.1.20 Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
name: glucuronolactone reductase
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_d47052ae_7567_4cc9_96d2_579b8433fa4e
boundary condition: true
has only substance units: false
name: GALNT14
is: Q96FL9
is encoded by: hsa:79623
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_b50e50e5_0b4d_401e_88f8_f9e051bf6b02
is: SBO:0000252
is encoded by: hsa:57835
name: SLC4A5
type: Species
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_4066a5d1_9358_491f_ac2d_851f99f1db40
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:570
initial concentration: NaN
constant: false
is: Q14032
type: Species
name: BAAT

metaR DAGK hs
is version of: http://identifiers.org/ec-code/2.7.1.107
name: Diacylglycerol phosphate kinase (homo sapiens)
kinetic law: MODEL1310110003#
reversible: true
fast: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110003#

metaM lnlc r
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC00796 EHMN_ABBREVIATION: C01595
is: HMDB00673
is: CHEBI:30245
constant: false
type: Species
is: SBO:0000247
name: linoleate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_77e0fd4e_5783_4a00_8811_3d702e7bdc3d
is: SBO:0000252
type: Species
name: B4GALT5
boundary condition: true
has only substance units: false
is encoded by: hsa:9334
initial amount: NaN
is: O43286
constant: false
initial concentration: NaN

metaM ha deg1 l
notes: FORMULA: C22H33N2O16 CHARGE: -1
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
type: Species
name: hyaluronan degradation product 1
is: CHEBI:16336
is: SBO:0000247
has only substance units: false

metaM ahcys c
is: C00021
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:16680
is: HMDB00939
boundary condition: false
name: S-Adenosyl-L-homocysteine
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_0e511e0e_2b30_4489_a42d_63b6aa379f68
initial concentration: NaN
name: NDUFB1
has only substance units: false
is: O75438
type: Species
constant: false
is encoded by: hsa:4707
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR RE2814R
name: RE2814
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:

metaM CE2434 m
initial amount: NaN
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
initial concentration: 1.0
type: Species
is: CHEBI:57795

metaR AG13T10g
kinetic law: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction

metaM e4hglu m
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: HMDB02273
is: CHEBI:6331
name: erythro-4-hydroxy-L-glutamate(1-)
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947

metaM acac c
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: SBO:0000247
is: HMDB00060
initial amount: NaN
constant: false
name: acetoacetate
initial concentration: 1.0
is: CHEBI:13705
type: Species
has only substance units: false
boundary condition: false

metaM CE5160 r
is: HMDB00127
name: 3-oxo-cis-9-octadecenoyl-CoA
is: CHEBI:15748
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
has only substance units: false
initial amount: NaN

metaM fprica c
type: Species
is: CHEBI:58467
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: C04734
constant: false
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
is: HMDB01439

metaR r1623
fast: false
is: SBO:0000185
product: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110003#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110003#_06e404aa_cb90_41f1_9f6c_994ea5a9866a
constant: false
name: DOLPP1
is encoded by: hsa:57171
initial amount: NaN
boundary condition: true
is: Q86YN1
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN

metaR FORtr
kinetic law: MODEL1310110003#
fast: false
name: FOR transporter, endoplasmic reticulum
reversible: true
is: SBO:0000185
type: Reaction
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110003#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_1b7758ae_1bf9_47e9_bce9_e4e6cacacd91
type: Species
is encoded by: hsa:7084
boundary condition: true
is: O00142
name: TK2
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaM ksi pre34 g
is: CHEBI:58053
initial amount: NaN
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 34
type: Species
is: SBO:0000247
constant: false
is: C00130
is: HMDB00175
initial concentration: 1.0
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_ecf7b835_e0e0_42f3_8f5d_92ba563eda4f
boundary condition: true
is: SBO:0000252
type: Species
name: _AI684467_1_m
initial concentration: NaN
is encoded by: hsa:AI684467
has only substance units: false
initial amount: NaN
constant: false

metaR C14STRr
name: C-14 sterol reductase
fast: false
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.3.1.70
reversible: false
reactant: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
type: Reaction
product: MODEL1310110003#

metaR G6PDH2rer
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
fast: false
reactant: MODEL1310110003#
is described by: ECO:0000269
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
is: SBO:0000176
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.47

http://identifiers.org/biomodels.db/MODEL1310110003#_b070bb48_32c6_456b_b874_7a6d05db291b
is encoded by: hsa:AI024818
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: _AI024818_1_c
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_3e03f06f_6425_41a8_9dec_b12d38d6ea1b
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is: Q9BQL0
constant: false
is encoded by: hsa:594
name: BCKDHB
initial amount: NaN

metaM hmgcoa m
type: Species
boundary condition: false
has only substance units: false
is: HMDB01375
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial amount: NaN
name: Hydroxymethylglutaryl-CoA
is: CHEBI:15467
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_6fc50add_349c_4ef8_b7eb_9fc2aac68ed1
constant: false
name: SLC24A1
is: B4DUG1
is encoded by: hsa:9187
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species

metaR r0531
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.34
reactant: MODEL1310110003#
type: Reaction

metaR r1624
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185
modifier: MODEL1310110003#
reversible: true
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR RNMK
notes: GENE_ASSOCIATION: (54981.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.1.22 Confidence Level: 4 AUTHORS: PMID:15137942 NOTES:
kinetic law: MODEL1310110003#
is: SBO:0000176
modifier: MODEL1310110003#
reversible: false
fast: false
reactant: MODEL1310110003#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.1.22
name: ribosylnicotinamide kinase

http://identifiers.org/biomodels.db/MODEL1310110003#_15389159_0659_47f0_a4b3_6fec4dd85e20
has only substance units: false
name: SLC23A2
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:9962
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR CHLtm
product: MODEL1310110003#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110003#
name: choline transport via diffusion (cytosol to mitochondria)
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:

metaM xol7ah2al c
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:27428
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
boundary condition: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: HMDB06894
is: SBO:0000247
constant: false
initial amount: NaN

metaR GLCNACASE4ly
is: SBO:0000176
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.2.1.50
fast: false
product: MODEL1310110003#
name: alpha-N-acetylglucosaminidase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
reversible: false
type: Reaction
modifier: MODEL1310110003#

metaR KHte
name: KHte
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
fast: false
product: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_b36c0f30_af5e_429b_8c4b_b825ad5764ac
name: NDUFS1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P28331
has only substance units: false
constant: false
is encoded by: hsa:4719
type: Species
initial amount: NaN

metaM h2o x
name: H2O
is: CHEBI:15377
constant: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
initial amount: NaN
is: C00001
is: HMDB02111
has only substance units: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_04ab83d7_121b_49e1_82df_31ba8bd74f8c
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:6319
is: O00767
is: SBO:0000252
has only substance units: false
name: SCD
type: Species
initial amount: NaN

metaR r0186
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_3342222a_7c55_44d8_87a2_7e738b1bbdaf
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is: SBO:0000252
name: FADS2
is encoded by: hsa:9415
is: O95864
initial amount: NaN
boundary condition: true

metaR GGH 6DHFe
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
product: MODEL1310110003#
is: SBO:0000176
name: Gamma-glutamyl hydrolase (6DHF), extracellular
modifier: MODEL1310110003#
fast: false
reversible: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_29d59df4_2850_47e1_bc50_6c64a50809e7
initial concentration: NaN
is: Q9Y345
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: SLC6A5
constant: false
is encoded by: hsa:9152
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_eaed5b79_38c0_4354_ad5d_8761756aa6d8
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:60490
is: Q96CD2
name: PPCDC

metaR r1625
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
modifier: MODEL1310110003#

metaM acac e
initial amount: NaN
is: HMDB00060
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
name: acetoacetate
constant: false
is: CHEBI:13705
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
initial concentration: 1.0

metaR ALAt2r
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
is described by: ECO:0000304
name: L-alanine reversible transport via proton symport
kinetic law: MODEL1310110003#
is: SBO:0000185
type: Reaction
fast: false

metaR TCHOLAte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reactant: MODEL1310110003#
fast: false
type: Reaction
name: bile acid intracellular transport
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000000
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_10a346a1_95a3_427f_99a7_f39387072261
is encoded by: hsa:2542
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
has only substance units: false
name: SLC37A4
boundary condition: true
constant: false
is: A8K0S7

metaR AMPtp
name: AMP transporter, peroxisome
reversible: true
is described by: ECO:0000000
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
reactant: MODEL1310110003#
type: Reaction
fast: false
kinetic law: MODEL1310110003#
is: SBO:0000185

metaR Htr
reactant: MODEL1310110003#
is described by: ECO:0000000
kinetic law: MODEL1310110003#
product: MODEL1310110003#
name: H transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is: SBO:0000185
fast: false
reversible: true
type: Reaction

metaR r0650
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
is: SBO:0000176
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.36
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_1bd671c1_c59b_421d_9318_d35566ff63ac
name: CDIPT
initial amount: NaN
is: A8K3L7
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:10423
type: Species
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_ec8afa6c_7075_49ad_a334_732e46fd94db
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:123041
boundary condition: true
has only substance units: false
type: Species
constant: false
name: SLC24A4

metaR r1626
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_8f164bfb_3c72_4bfd_8f20_443f541dd0c7
is: P14679
name: TYR
initial concentration: NaN
initial amount: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:7299
type: Species
boundary condition: true

metaM HC02205 c
boundary condition: false
is: CHEBI:28099
is: SBO:0000247
initial concentration: 1.0
constant: false
name: prostaglandin-b2
has only substance units: false
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
initial amount: NaN

metaR EX prostge2 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_4acab233_df1d_4040_a071_3da3a57531ae
type: Species
is encoded by: hsa:LOC727762
has only substance units: false
constant: false
name: _LOC727762_1_m
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM phe L m
name: L-phenylalanine
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: HMDB00159
is: SBO:0000247
is: CHEBI:17295
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_7b43c9a5_6b52_44d5_8eac_2538095ccae8
is: SBO:0000252
is: O14521
name: SDHD
is encoded by: hsa:6392
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_1ce8755e_ce3c_4abc_83fd_59e5acea09e6
is: Q8NCL4
initial concentration: NaN
is encoded by: hsa:11226
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: GALNT6
constant: false
type: Species

metaR RE0830C
product: MODEL1310110003#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110003#
fast: false
name: RE0830

metaR r2059
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
reversible: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_ed4af62e_1a6e_46e2_ad0d_2821dc463ad2
name: _HG2846_HT2983_1_m
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:HG2846-HT2983

metaM srtn c
is: HMDB00259
is: CHEBI:350546
name: serotonin(1+)
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial concentration: 1.0
constant: false

metaR G14T15g
is: SBO:0000176
reversible: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38

http://identifiers.org/biomodels.db/MODEL1310110003#_09583967_7be8_4d23_9d20_f39890b7e8b7
name: PLCL1
is: Q15111
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:5334
boundary condition: true
has only substance units: false

metaR r0464
kinetic law: MODEL1310110003#
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
type: Reaction
product: MODEL1310110003#
is: SBO:0000176
reactant: MODEL1310110003#
is described by: ECO:0000000
reversible: true

metaR r0651
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is: SBO:0000176
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
fast: false
reactant: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true

metaR RDH2
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
product: MODEL1310110003#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.315
fast: false
reactant: MODEL1310110003#
is: SBO:0000176
name: retinol dehydrogenase (9-cis,NADH)
reversible: true
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#

metaR CYANt
fast: false
kinetic law: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
name: Cyanide transport via diffusion (extracellular to cytosol)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_3aaf33c9_06ac_46e3_8d78_27779fedd859
boundary condition: true
constant: false
is encoded by: hsa:761
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: CA3
type: Species
is: P07451

http://identifiers.org/biomodels.db/MODEL1310110003#_7c396cf6_a896_413e_a82e_d56c11fee5eb
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: COASY
is encoded by: hsa:80347
type: Species
is: Q13057

metaM HC02202 c
is: SBO:0000247
has only substance units: false
name: prostaglandin A1(1-)
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial concentration: 1.0
type: Species
is: CHEBI:57398
boundary condition: false
constant: false

metaM didp c
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28823
type: Species
initial amount: NaN
name: dIDP
constant: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: HMDB03536
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_e629d476_8537_4a27_995b_323280fe70b6
constant: false
name: INPP5J
is encoded by: hsa:27124
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaR CYTDK1
is: SBO:0000176
is described by: ECO:0000254
modifier: MODEL1310110003#
product: MODEL1310110003#
name: ATPcytidine 5-phosphotransferase
reversible: false
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
fast: false
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.48

metaM met L c
name: L-methionine
is: CHEBI:16643
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
is: HMDB00696
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_46b4fb09_eb38_48de_a426_a6690980ef89
constant: false
is: P30837
boundary condition: true
type: Species
has only substance units: false
initial concentration: NaN
name: ALDH1B1
initial amount: NaN
is encoded by: hsa:219
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_06d896f0_814f_48c3_8433_86c886197ebd
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8525
is: B7Z6M3
name: DGKZ
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species

metaR GLYPHEPEPT1tc
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaR r1627
product: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ile L m
initial amount: NaN
is: HMDB00172
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
boundary condition: false
initial concentration: 1.0
is: CHEBI:17191
type: Species
name: L-isoleucine
constant: false

metaM HC00695 m
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
name: S-Succinyldihydrolipoamide
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
is: CHEBI:17432
has only substance units: false

metaR DPCOAPPe
name: Pyrophasphatase (dephospho-CoA, extracellular)
reactant: MODEL1310110003#
reversible: false
type: Reaction
is: SBO:0000176
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
fast: false

metaR r0885
fast: false
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
product: MODEL1310110003#
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.3.1.38
reversible: true
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185

metaR SPHMYLNtg
is described by: ECO:0000000
reversible: true
type: Reaction
fast: false
is: SBO:0000185
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
product: MODEL1310110003#
reactant: MODEL1310110003#
name: sphingomyelin intracellular transport

metaR MI14Ptn
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110003#
is described by: ECO:0000000
name: inositol 1,4-bisphosphate nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction

metaR r0652
is version of: http://identifiers.org/ec-code/1.5.1.2
fast: false
is described by: ECO:0000000
reactant: MODEL1310110003#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
product: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:

metaR RDH3
is version of: http://identifiers.org/ec-code/1.1.1.315
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000269
is: SBO:0000176
reversible: true
modifier: MODEL1310110003#
fast: false
type: Reaction
name: retinol dehydrogenase (11-cis,NADH)
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
reactant: MODEL1310110003#

metaR GLCMter
fast: false
reactant: MODEL1310110003#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11882499 NOTES:NCD
name: glucose transport via membrane vesicle
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR SO4tl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110003#
name: Sulfate transport (lysosome)
product: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
fast: false
reversible: true
type: Reaction

metaR r0990
is described by: ECO:0000000
name: Postulated transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110003#
fast: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185

metaR DNDPt17m
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000185
name: dUDP transport via dCDP antiport
fast: false
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110003#_bd2899c9_2889_4f47_a620_a1e47edf1dac
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is: E5KS60
is encoded by: hsa:8803
constant: false
boundary condition: true
name: SUCLA2
initial amount: NaN

metaR THP2Ctp
reversible: true
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
is described by: ECO:0000000
fast: false
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_f0ae1004_3d81_4231_91ec_3e648f312acc
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:1719
boundary condition: true
name: DHFR
type: Species
is: P00374
is: SBO:0000252

metaM glutcoa m
is: HMDB01339
name: glutaryl-CoA(5-)
is: SBO:0000247
has only substance units: false
is: CHEBI:57378
boundary condition: false
type: Species
constant: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
initial concentration: 1.0
initial amount: NaN

metaR CHOLt4
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
reversible: true
fast: false
product: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
name: choline, sodium cotransport
is described by: ECO:0000269
is: SBO:0000185
reactant: MODEL1310110003#

metaM 4abut e
boundary condition: false
is: SBO:0000247
name: 4-Aminobutanoate
initial amount: NaN
is: CHEBI:3628
type: Species
is: C00334
constant: false
is: HMDB00112
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_f67da50d_2761_49c7_ac9c_99ba3fcf8daa
initial amount: NaN
is: Q9UBM7
boundary condition: true
type: Species
is encoded by: hsa:1717
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: DHCR7
constant: false

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaR r1628
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#

metaM pac c
type: Species
initial concentration: 1.0
name: phenylacetate
is: SBO:0000247
is: CHEBI:18401
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB00209
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086

metaM HC02205 e
constant: false
is: CHEBI:28099
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: prostaglandin-b2
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954

http://identifiers.org/biomodels.db/MODEL1310110003#_728eeb37_2a65_4638_b3a0_e6a0e0b00dd9
name: ACOT6
is encoded by: hsa:641372
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: Q3I5F7
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_04a02e6f_81d3_454e_9fae_40716b7ef886
initial amount: NaN
constant: false
is: Q16698
is: SBO:0000252
name: DECR1
type: Species
boundary condition: true
is encoded by: hsa:1666
has only substance units: false
initial concentration: NaN

metaR r0653
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
product: MODEL1310110003#
is: SBO:0000176
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
reactant: MODEL1310110003#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110003#_3b66b2e6_5ce6_459e_85b1_6592562fba80
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
name: HGD
has only substance units: false
is encoded by: hsa:3081
is: Q93099
boundary condition: true

metaM srtn e
is: SBO:0000247
name: serotonin(1+)
initial amount: NaN
type: Species
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
initial concentration: 1.0
is: HMDB00259
is: CHEBI:350546

metaM trdrd c
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15967
name: Reduced thioredoxin
is: C00342
type: Species

metaM leuktrB4 e
is: HMDB01085
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
name: leukotriene B4(1-)
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: CHEBI:57461
initial concentration: 1.0
is: SBO:0000247

metaM HC02202 e
name: prostaglandin A1(1-)
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false
is: CHEBI:57398
initial concentration: 1.0
type: Species
constant: false

metaR DALAxt
name: D-Alanine transport to perixosome
reactant: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
fast: false
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: D-alanine metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_c77773ce_59a9_4416_87be_edefd3b4406c
name: INPP5A
is: Q14642
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:3632

metaM nadh x
is: http://identifiers.org/pubchem.compound/3306
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB01487
has only substance units: false
constant: false
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
is: CHEBI:57945
boundary condition: false
initial amount: NaN

metaM hs deg25 l
is: CHEBI:16126
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C23H37O21 CHARGE: -1
is: SBO:0000247
type: Species
name: GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose

metaM met L e
has only substance units: false
is: HMDB00696
is: CHEBI:16643
name: L-methionine
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110003#_269c5914_1a23_4332_a684_6eb0a6f73c50
name: HSD17B7
is: P56937
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:51478

http://identifiers.org/biomodels.db/MODEL1310110003#_ada73c30_728c_4b57_9d08_95d96cffdb49
type: Species
name: NME1
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4830
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_48e72aa8_7285_46d8_b1e6_f2c995cc2a3f
initial concentration: NaN
name: _AI601100_1_m
boundary condition: true
initial amount: NaN
constant: false
type: Species
has only substance units: false
is encoded by: hsa:AI601100
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_2bf8c983_b9cc_4d8b_a3b4_5bc96a75b8db
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:6184
has only substance units: false
initial concentration: NaN
type: Species
name: RPN1
is: P04843

metaR GDPtg
product: MODEL1310110003#
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
kinetic law: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
fast: false
name: GDP intracellular transport

metaR r1629
is described by: ECO:0000000
type: Reaction
product: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110003#_f40a5908_2076_4967_9e4f_9f280dc7a152
constant: false
initial amount: NaN
is: SBO:0000252
name: PDHA2
type: Species
is encoded by: hsa:5161
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P29803

metaR G3PD1
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
name: glycerol-3-phosphate dehydrogenase (NAD)
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110003#
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.8
reversible: true
product: MODEL1310110003#
is: SBO:0000176

metaM dttp c
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:37568
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB01342
is: C00459
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
name: dTTP
has only substance units: false

metaR RDH1
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
name: retinol dehydrogenase (all-trans)
product: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000269
reversible: true
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.315
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
type: Reaction

metaM 3otdcoa m
type: Species
is: SBO:0000247
is: HMDB03935
name: 3-Oxotetradecanoyl-CoA
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
boundary condition: false
has only substance units: false
is: CHEBI:28726
initial concentration: 1.0
initial amount: NaN
constant: false

metaM HC01118 r
is: SBO:0000247
name: presqualene diphosphate(3-)
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
initial concentration: 1.0
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:57310

metaR UDPG4E
is described by: ECO:0000134
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/5.1.3.2
reversible: true
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
modifier: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#
fast: false
name: UDPglucose 4-epimerase

http://identifiers.org/biomodels.db/MODEL1310110003#_11a97488_f7cc_4038_ad92_68e98fdd7a4c
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
is encoded by: hsa:79087
type: Species
has only substance units: false
is: Q9BV10
name: ALG12
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_aaf5f6ab_243c_4ce9_bb75_56eea23c7715
has only substance units: false
is: SBO:0000252
is: P08559
initial concentration: NaN
initial amount: NaN
constant: false
name: PDHA1
type: Species
is encoded by: hsa:5160
boundary condition: true

metaR OIVD3m
is: SBO:0000176
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#
fast: false
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxopentanoate), mitochondrial
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
reactant: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.2.4.4
is version of: http://identifiers.org/ec-code/2.3.1.168

http://identifiers.org/biomodels.db/MODEL1310110003#_62a523cf_5a5f_4b9c_8c46_5d8773b99ec8
name: HAL
is encoded by: hsa:3034
initial amount: NaN
is: B4E0V8
boundary condition: true
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN

metaM 4abut c
type: Species
is: CHEBI:3628
has only substance units: false
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0
initial amount: NaN
boundary condition: false
name: 4-Aminobutanoate
is: C00334
initial concentration: 1.0
is: HMDB00112
is: SBO:0000247

metaR URCN
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.49
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
is described by: ECO:0000269
reversible: false
name: URCN
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_381836cd_7e46_4ce7_b0d8_8584cc7d2cc5
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:55
type: Species
is: SBO:0000252
name: ACPP
boundary condition: true
is: P15309
constant: false

metaR RETt
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110003#
fast: false
type: Reaction
name: Retinol transport via faciliated diffusion
is: SBO:0000185
product: MODEL1310110003#
kinetic law: MODEL1310110003#

metaR ALAGLNexR
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110003#
fast: false
is described by: ECO:0000304
reactant: MODEL1310110003#
reversible: true
modifier: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
is: SBO:0000185
name: L-alanine/glutamine reversible exchange

metaM malthp e
constant: false
initial concentration: 1.0
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
name: maltoheptaose
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C01936
is: http://identifiers.org/pubchem.compound/5041
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_9acee79c_50c8_42f0_8644_bd6fddc0abe6
initial amount: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:5331
name: PLCB3
initial concentration: NaN
constant: false
is: G5E960
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_9fe193b0_45ef_4828_813d_23f3376022e2
constant: false
type: Species
is: B2R6S5
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: CMPK1
is encoded by: hsa:51727

http://identifiers.org/biomodels.db/MODEL1310110003#_b9f7143d_b920_4cc1_816c_cd951b9a0188
is: Q99714
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:3028
has only substance units: false
name: HSD17B10
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_6982d77f_2fe4_441c_ac8a_f4039f27ca57
type: Species
is: Q92820
is encoded by: hsa:8836
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
name: GGH
constant: false
is: SBO:0000252

metaR G6Pter
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
kinetic law: MODEL1310110003#
type: Reaction
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
reversible: true
is described by: ECO:0000269
product: MODEL1310110003#
modifier: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#
fast: false

metaM h2o m
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: H2O
type: Species
initial amount: NaN
is: CHEBI:15377
is: HMDB02111
initial concentration: 1.0
is: C00001
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247

metaR PPItr
is: SBO:0000185
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
is described by: ECO:0000000
fast: false
name: Diphosphate transporter, endoplasmic reticulum
product: MODEL1310110003#
reversible: true
kinetic law: MODEL1310110003#

metaR r2386
reactant: MODEL1310110003#
fast: false
reversible: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaM nad c
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3305
type: Species
has only substance units: false
constant: false
is: C00003
is: CHEBI:57540
is: HMDB00902
boundary condition: false
initial amount: NaN
name: Nicotinamide adenine dinucleotide
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_fb424933_a1b8_4c61_9550_5b4df03cd774
name: IDH2
is: P48735
is encoded by: hsa:3418
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
initial amount: NaN

metaM hs deg1 l
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00719
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
is: SBO:0000247
is: CHEBI:15699
name: heparan sulfate, degradation product 1
constant: false
initial amount: NaN

metaM adp r
is: SBO:0000247
initial amount: NaN
is: HMDB01341
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
boundary condition: false
name: ADP(3-)
is: CHEBI:456216

metaR OIVD2m
fast: false
reversible: false
modifier: MODEL1310110003#
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.2.4.4
type: Reaction
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxobutanoate), mitochondrial
is described by: ECO:0000269
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
is: SBO:0000176
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.168

http://identifiers.org/biomodels.db/MODEL1310110003#_e2e77bb1_6b97_406e_9e1f_ef60b5ffb647
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: CTSA
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5476
is: P10619
initial amount: NaN

metaR r0193
is: SBO:0000176
kinetic law: MODEL1310110003#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
is described by: ECO:0000000
product: MODEL1310110003#
reactant: MODEL1310110003#
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_c3bdb1a9_4311_42ca_a29f_3913c46a48e5
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: FUT8
constant: false
is encoded by: hsa:2530
type: Species
boundary condition: true
is: Q9BYC5
has only substance units: false

metaR ITCOAL1m
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110003#
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
product: MODEL1310110003#
is: SBO:0000176
reversible: true
reactant: MODEL1310110003#
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_6d42ef1f_9044_4317_8c77_5e45025eb747
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
is: E7EML0
is encoded by: hsa:9498
type: Species
name: SLC4A8

metaR r0394
reactant: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
reversible: true
product: MODEL1310110003#
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
type: Reaction
fast: false
is described by: ECO:0000000

metaM so4 e
initial concentration: 1.0
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
name: sulfate
is: HMDB01448
boundary condition: false

metaM h2o n
name: water
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
is: HMDB02111
has only substance units: false
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

metaR r2062
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110003#
reactant: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
kinetic law: MODEL1310110003#
reversible: false
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r2387
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
product: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR r1619
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110003#
is: SBO:0000185
type: Reaction
modifier: MODEL1310110003#
product: MODEL1310110003#
reversible: true
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_b3dc1f71_f1af_4b69_af97_0163fc98547a
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: PAICS
boundary condition: true
is: P22234
is encoded by: hsa:10606
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_3dc94d4c_d385_4e9e_b275_921ec6e8b2bf
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN
is: Q9BV79
name: MECR
has only substance units: false
is: SBO:0000252
is encoded by: hsa:51102
type: Species

metaR GLCAASE1ly
name: beta-glucuronidase, lysosomal
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
modifier: MODEL1310110003#
product: MODEL1310110003#
reversible: false
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.2.1.31

metaM hs deg10 l
initial amount: NaN
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
type: Species
boundary condition: false
has only substance units: false
name: heparan sulfate, degradation product 10
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15748
is: HMDB00127

http://identifiers.org/biomodels.db/MODEL1310110003#_b4196e63_d30e_4e8a_8afe_218b301ed59d
is: Q99808
is: SBO:0000252
is encoded by: hsa:2030
initial amount: NaN
name: SLC29A1
boundary condition: true
initial concentration: NaN
type: Species
constant: false
has only substance units: false

metaR MTHGXLt
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:MM
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: false
is: SBO:0000185
name: Methylglyoxal transport (cytosol to extracellular)
fast: false
kinetic law: MODEL1310110003#

metaR EX strch1 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: starch, structure 1 (1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
type: Reaction

metaR ABTti
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
reversible: false
name: L-arabinitol transport via passive diffusion
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110003#

metaR RE1520M
is: SBO:0000176
name: RE1520
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
product: MODEL1310110003#
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_000a3991_8e18_4d1c_8f29_9f3da320463c
name: SDHD
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:6392
initial concentration: NaN
is: O14521

metaM cytd c
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB00089
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: CHEBI:17562
is: SBO:0000247
is: C00475
type: Species
boundary condition: false
name: Cytidine
has only substance units: false

metaR r1841
reactant: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110003#

metaM alpam m
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
is: HMDB06239
boundary condition: false
name: S-aminomethyldihydrolipoamide
has only substance units: false
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
is: SBO:0000247

metaM dttp n
boundary condition: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial amount: NaN
initial concentration: 1.0
constant: false
is: C00459
has only substance units: false
name: dTTP
is: HMDB01342
type: Species
is: SBO:0000247
is: CHEBI:37568

metaR r0242
reactant: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000000
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.1
kinetic law: MODEL1310110003#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:

metaR r0395
reversible: true
fast: false
name: Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
is described by: ECO:0000000
product: MODEL1310110003#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_11fd8a93_f02e_4bb7_a2d1_262c48abc647
constant: false
is: SBO:0000252
type: Species
name: _AA977580_1_c
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA977580
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_1fd8014c_214c_4b69_b4f0_b4403e73d15d
boundary condition: true
name: SLC34A1
is encoded by: hsa:6569
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: Q7Z725
is: SBO:0000252

metaM so4 c
name: sulfate
type: Species
is: SBO:0000247
is: HMDB01448
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16189
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false

metaR RE3347C
is described by: ECO:0000000
name: RE3347
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
reactant: MODEL1310110003#
fast: false
is: SBO:0000176

metaM leu L m
type: Species
name: L-leucine
has only substance units: false
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial concentration: 1.0
is: CHEBI:15603
is: SBO:0000247
boundary condition: false
is: HMDB00687
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_e99136ee_37f0_4032_982b_2909f3d5492a
is: P07864
type: Species
has only substance units: false
name: LDHC
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:3948

metaM focytC m
has only substance units: false
is: CHEBI:16928
initial amount: NaN
name: Ferrocytochrome C
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_8e6a5f3d_e897_416e_b12b_c60e00b4c95f
is: SBO:0000252
constant: false
is: O95436
boundary condition: true
initial concentration: NaN
type: Species
name: SLC34A2
is encoded by: hsa:10568
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_98422443_6210_4236_9eec_864c3096cf5a
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: NDUFS7
is: O75251
type: Species
is: SBO:0000252
is encoded by: hsa:374291

http://identifiers.org/biomodels.db/MODEL1310110003#_2a70f7da_7b8d_4b0b_a3e2_61fc4ce72ce3
has only substance units: false
type: Species
name: SLC7A5
initial concentration: NaN
is encoded by: hsa:8140
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q8IV97

metaR r2384
kinetic law: MODEL1310110003#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
is: SBO:0000185
reversible: false
fast: false
modifier: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR DOLPGT1 Uer
fast: false
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.267
kinetic law: MODEL1310110003#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
reactant: MODEL1310110003#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110003#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110003#_5e28c3ca_2ebd_4cde_a308_e1cb8526126b
initial concentration: NaN
is encoded by: hsa:1109
type: Species
constant: false
name: AKR1C4
initial amount: NaN
boundary condition: true
has only substance units: false
is: P17516
is: SBO:0000252

metaR r0392
product: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
is: SBO:0000176
reactant: MODEL1310110003#
fast: false
reversible: true
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
type: Reaction
kinetic law: MODEL1310110003#

metaR GACMTRc
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.1.1.2
kinetic law: MODEL1310110003#
fast: false
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (2593.1) or (2593.2) SUBSYSTEM: Urea cycle EC Number: 2.1.1.2 Confidence Level: 4 AUTHORS: PMID:2001229 NOTES:SAB c
product: MODEL1310110003#
modifier: MODEL1310110003#
name: guanidinoacetate N-methyltransferase (c)
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110003#_73a65902_897c_41c9_be7c_997aa052111e
is: SBO:0000252
type: Species
boundary condition: true
name: NDUFA10
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: O95299
is encoded by: hsa:4705

http://identifiers.org/biomodels.db/MODEL1310110003#_3705a64b_5ab0_4a24_9a14_0fa2fb2f2db4
initial amount: NaN
is encoded by: hsa:92483
name: LDHAL6B
initial concentration: NaN
type: Species
is: Q9BYZ2
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_70fc2585_ee27_4fb6_ac32_2cae29f8d524
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
type: Species
name: _AI620219_1_e
initial amount: NaN
is encoded by: hsa:AI620219
initial concentration: NaN

metaR DNDPt30m
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dCDP transport via ADP antiport
reversible: false
modifier: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110003#

metaR r2385
is described by: ECO:0000000
kinetic law: MODEL1310110003#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
modifier: MODEL1310110003#
product: MODEL1310110003#
fast: false
reversible: false
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_0b2e8c89_0362_4d4c_88a4_573b24e849bb
initial amount: NaN
is encoded by: hsa:U52111
constant: false
initial concentration: NaN
name: _U52111_1_c
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species

metaM acnacngalgbside hs c
is: SBO:0000247
has only substance units: false
is: HMDB00223
initial amount: NaN
constant: false
name: disialyl galactosylgloboside
is: CHEBI:3338
boundary condition: false
is: C00036
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
initial concentration: 1.0
type: Species

metaR LNSTLSr
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
modifier: MODEL1310110003#
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: false
name: lanosterol synthase
type: Reaction
is described by: ECO:0000134
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/5.4.99.7

http://identifiers.org/biomodels.db/MODEL1310110003#_bb99514d_fada_4651_902e_5658b1f8bd97
is: P27707
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:1633
name: DCK
is: SBO:0000252
boundary condition: true

metaM acac m
type: Species
is: CHEBI:13705
has only substance units: false
is: HMDB00060
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
name: acetoacetate
boundary condition: false
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164

metaM crm hs c
initial concentration: 1.0
is: CHEBI:52639
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
type: Species
name: N-acylsphingosine
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
has only substance units: false

metaM frdp c
is: CHEBI:175763
type: Species
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: SBO:0000247
constant: false
is: HMDB00961
has only substance units: false
name: Farnesyl diphosphate
initial concentration: 1.0
boundary condition: false
is: C00448
initial amount: NaN

metaR r0393
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
reactant: MODEL1310110003#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_b02ba262_87c2_48f3_8a10_363fd2d42d01
name: QPRT
is: Q15274
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:23475

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaM cdp n
initial amount: NaN
is: HMDB01546
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:58069
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
name: CDP(3-)

http://identifiers.org/biomodels.db/MODEL1310110003#_efd9425c_38a8_4e31_9b45_323e1c14551e
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _R51273_1_c
is encoded by: hsa:R51273
initial amount: NaN
type: Species

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

metaR EX HC02204 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_be0ab839_4644_4afd_876c_e623ccd5b43c
name: B3GALT5
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:10317

http://identifiers.org/biomodels.db/MODEL1310110003#_4bd53d72_4d02_40db_a96f_eea418c925b1
initial amount: NaN
boundary condition: true
is: Q9H310
is encoded by: hsa:57127
name: RHBG
constant: false
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaR DESAT18 3
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.14.19.1
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
reversible: false
notes: GENE_ASSOCIATION: (6319.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: PMID:14967823 NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110003#
type: Reaction
is: SBO:0000176
fast: false
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

http://identifiers.org/biomodels.db/MODEL1310110003#_b99063ad_0066_40c3_b5ba_07621fd7f576
type: Species
is encoded by: hsa:8613
boundary condition: true
is: O14495
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: PPAP2B
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_efc641cb_175b_4ba2_95ed_3e77b09d7099
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:4708
is: H7C5B8
name: NDUFB2

http://identifiers.org/biomodels.db/MODEL1310110003#_2a8ad649_9730_4476_a954_42d62fb04826
constant: false
name: INPP5J
initial concentration: NaN
is encoded by: hsa:27124
boundary condition: true
is: SBO:0000252
is: Q15735
initial amount: NaN
has only substance units: false
type: Species

metaM adp n
boundary condition: false
type: Species
initial amount: NaN
name: ADP(3-)
is: CHEBI:456216
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01341
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008

http://identifiers.org/biomodels.db/MODEL1310110003#_661908fb_8ad0_43e8_879e_9f57f80822c1
type: Species
is: Q12882
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: DPYD
is: SBO:0000252
constant: false
is encoded by: hsa:1806

http://identifiers.org/biomodels.db/MODEL1310110003#_5ca580f6_aaba_4c36_9563_b6e0bda796fd
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is: P14550
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:10327
name: AKR1A1
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_efa1e46f_15cb_4838_b206_87d0b3f8f5f6
is: SBO:0000252
is encoded by: hsa:3707
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: ITPKB
is: P27987
boundary condition: true
constant: false
type: Species

metaR FUMSO3tm
type: Reaction
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
is: SBO:0000185
name: Fumarate:sulfite antiport, mitochondrial
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
is described by: ECO:0000269

metaM fad r
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 INCHI: InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
has only substance units: false
initial amount: NaN
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized
is: HMDB01248
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_8c2107e5_00b0_4944_984f_cf461bd8c4f9
name: MAN2B1
initial concentration: NaN
is: O00754
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:4125

http://identifiers.org/biomodels.db/MODEL1310110003#_02a8be52_6b90_4ff9_a214_09e0bb2714c7
initial concentration: NaN
name: DGKB
boundary condition: true
initial amount: NaN
is: Q9Y6T7
constant: false
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:1607

metaR r1991
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110003#
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
type: Reaction
reversible: false
is: SBO:0000185
product: MODEL1310110003#
name: Y+LAT2 Utilized transport

metaR r0245
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is: SBO:0000176
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_f2079fa8_8bc9_4224_a415_c10c2f3ff468
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:8527
name: DGKD
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_e56fe3e3_2f39_4adb_993c_f03586eafaac
name: NME4
constant: false
has only substance units: false
is encoded by: hsa:4833
is: O00746
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252

metaR RE1807C
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
is: SBO:0000176
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110003#
name: RE1807
type: Reaction
product: MODEL1310110003#

metaM lac D c
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
is: CHEBI:16004
constant: false
boundary condition: false
name: (R)-lactate
is: HMDB01311
is: SBO:0000247
initial amount: NaN

metaR r0390
kinetic law: MODEL1310110003#
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110003#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
product: MODEL1310110003#
type: Reaction

metaR L LACt4r
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
reversible: true
name: L-lactate reversible transport via sodium symport
type: Reaction
is described by: ECO:0000000
product: MODEL1310110003#

metaM dmpp x
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
name: prenyl diphosphate(3-)
is: CHEBI:57623
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
has only substance units: false
is: HMDB01120
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_70d481de_1ab5_4a9b_9d2b_083545f1e81b
is: SBO:0000252
initial amount: NaN
is: Q5QPH3
initial concentration: NaN
type: Species
is encoded by: hsa:55902
constant: false
name: ACSS2
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_d7b8fa5a_6d2a_4371_877e_80ea8d06af32
initial amount: NaN
has part: Q9UHI5
boundary condition: true
has only substance units: false
is encoded by: hsa:23428
name: SLC7A8:SLC3A2
type: Species
constant: false
is: SBO:0000297
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_3912ce8d_acbe_4cdc_a915_4ea5b136f22d
constant: false
name: SDS
is encoded by: hsa:10993
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is: P20132
is: SBO:0000252
boundary condition: true

metaR EX arachcoa LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: arachidyl coenzyme A exchange
type: Reaction

metaM h2o r
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
name: H2O
initial amount: NaN
is: C00001
boundary condition: false
constant: false
is: CHEBI:15377
is: SBO:0000247
initial concentration: 1.0
is: HMDB02111
type: Species

metaR RE3524R
name: RE3524
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
product: MODEL1310110003#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
reversible: true

metaM CE0713 m
name: 3-oxolinoleoyl-CoA
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02329
type: Species
boundary condition: false
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
is: SBO:0000247
has only substance units: false
is: CHEBI:30623

metaM adp m
is: C00008
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01341
is: CHEBI:456216
name: ADP
is: http://identifiers.org/pubchem.compound/3310
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM retinol 9 cis c
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: 9-cis-retinol
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
is: CHEBI:17336
initial concentration: 1.0
is: HMDB06217
constant: false
has only substance units: false

metaM acnacngalgbside hs e
initial concentration: 1.0
is: HMDB00223
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:3338
name: disialyl galactosylgloboside
has only substance units: false
type: Species
is: C00036
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
boundary condition: false

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaM HC02121 c
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
name: S-(hydroxymethyl)glutathione(1-)
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
is: CHEBI:58758

metaR PPItx
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
type: Reaction
product: MODEL1310110003#
name: Diphosphate transporter, peroxisome
reversible: true
is: SBO:0000185
reactant: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#

metaR r2308
reactant: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false

metaR r0246
fast: false
modifier: MODEL1310110003#
product: MODEL1310110003#
reversible: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.5.1.3
is: SBO:0000176
kinetic law: MODEL1310110003#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_c2301daa_9359_4644_bbcc_606417754ecc
constant: false
is encoded by: hsa:U37519
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: _U37519_1_e
boundary condition: true
initial concentration: NaN
type: Species

metaR r0391
is: SBO:0000176
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
kinetic law: MODEL1310110003#
reversible: true
type: Reaction
reactant: MODEL1310110003#
fast: false
is described by: ECO:0000000
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11

http://identifiers.org/biomodels.db/MODEL1310110003#_2a620c06_c539_44d8_8b92_8fdb51b22bf8
is: SBO:0000252
has only substance units: false
is: P00492
initial concentration: NaN
name: HPRT1
is encoded by: hsa:3251
initial amount: NaN
type: Species
boundary condition: true
constant: false

metaR ECOAH1m
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
is version of: http://identifiers.org/ec-code/4.2.1.18
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000304
is: SBO:0000176
fast: false
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110003#
reversible: true
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction

metaM pristcoa x
name: pristanoyl coa
is: SBO:0000247
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
constant: false
is: CHEBI:51341
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_05c0c3a4_e13f_4795_992a_2c53510d3dc1
has only substance units: false
is encoded by: hsa:206
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: _206_1_c
constant: false

metaM m3mpdol U c
is: CHEBI:37632
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog

metaR r2388
is: SBO:0000185
reversible: false
fast: false
product: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR LTC4CP
product: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reversible: true
type: Reaction
name: Leukotriene C4 carboxypeptidase
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_cb39c373_1e2d_4b2d_9bd7_ed4d9b2cac37
name: FASN
is encoded by: hsa:2194
constant: false
type: Species
is: P49327
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN

metaR r0311
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
modifier: MODEL1310110003#
product: MODEL1310110003#
type: Reaction

metaR ETOHt
is described by: ECO:0000000
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
reversible: true
type: Reaction
name: ethanol reversible transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110003#_c707479b_789c_4c6c_9bc1_1532889c7c44
type: Species
is: P31040
has only substance units: false
boundary condition: true
is encoded by: hsa:6389
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: SDHA
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_1a9f9771_5ffc_45a9_81e2_e65137a3706c
name: ALG6
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q9Y672
boundary condition: true
is: SBO:0000252
is encoded by: hsa:29929
constant: false
type: Species

metaR r1993
fast: false
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110003#
type: Reaction
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR PAIL HStn
is described by: ECO:0000000
reactant: MODEL1310110003#
is: SBO:0000185
name: phosphatidylinositol nuclear transport (diffusion)
fast: false
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110003#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_9f3fcf2b_4ede_4a90_aa33_f9bd0c635742
is: Q5QPH3
constant: false
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: ACSS2
has only substance units: false
initial concentration: NaN
is encoded by: hsa:55902

metaM itacon m
is: CHEBI:17240
is: SBO:0000247
constant: false
type: Species
has only substance units: false
is: HMDB02092
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: itaconate(2-)
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490

metaR G12MT2 U
is: SBO:0000176
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110003#
fast: false
product: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
reversible: false

metaM chol n
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
boundary condition: false
type: Species
name: choline
has only substance units: false
is: CHEBI:15354
is: HMDB00097
initial concentration: 1.0
constant: false

metaM udp c
has only substance units: false
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:58223
is: C00015
name: UDP
type: Species
is: HMDB00295

metaM lac D e
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: (R)-lactate
type: Species
is: HMDB01311
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:16004
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1

metaM acnacngalgbside hs g
name: disialyl galactosylgloboside
type: Species
has only substance units: false
is: C00036
initial concentration: 1.0
boundary condition: false
is: HMDB00223
is: SBO:0000247
constant: false
is: CHEBI:3338
initial amount: NaN
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110003#_61169ba7_1c82_419b_95f7_8c18c4bc175f
boundary condition: true
type: Species
constant: false
is encoded by: hsa:26
is: P19801
initial amount: NaN
is: SBO:0000252
name: ABP1
has only substance units: false
initial concentration: NaN

metaM dnad c
initial amount: NaN
is: CHEBI:18304
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
name: Deamino-NAD+
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
is: C00857
is: HMDB01179
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_a6037d7b_895e_425b_b16f_68d0f028be59
boundary condition: true
constant: false
name: NDUFB9
initial concentration: NaN
is: Q9Y6M9
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4715

http://identifiers.org/biomodels.db/MODEL1310110003#_2aac8e65_0fba_41d3_ab1c_2ec7b461978b
name: NDUFS7
initial concentration: NaN
is: O75251
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:374291
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_074ac7fc_2d04_47cc_91d3_d6be6dcf9090
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: ACAA1
type: Species
is: Q96CA6
is encoded by: hsa:30
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_f5b2be72_e849_4f9b_9aab_4dd89a461c42
is: P11310
constant: false
is encoded by: hsa:34
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
name: ACADM
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110003#_4210c7c7_c697_4ada_bc1c_a75cfb6e4955
name: UGP2
type: Species
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:7360
is: SBO:0000252

metaR r2389
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
type: Reaction
reversible: false
product: MODEL1310110003#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reactant: MODEL1310110003#
is described by: ECO:0000000

metaR TRPt
fast: false
reversible: true
is described by: ECO:0000269
product: MODEL1310110003#
modifier: MODEL1310110003#
reactant: MODEL1310110003#
is: SBO:0000185
name: L-tryptophan transport
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
type: Reaction
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_52a0048f_d21b_46fe_a94d_110195bb6f19
name: COX7B
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:1349
constant: false
is: P24311

metaM cholcoaone x
has only substance units: false
is: CHEBI:58507
constant: false
is: SBO:0000247
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
boundary condition: false
is: HMDB06891
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467

metaR r0310
reversible: false
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110003#
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_3b325bd2_0977_4c4c_9a2e_aed7ca6702ee
is: G3V5N0
initial amount: NaN
name: FUT8
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2530

metaR FAOXC180
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: false
fast: false
modifier: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_d9392725_8f06_4ca7_9696_675179e1860c
is: O95299
is encoded by: hsa:4705
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: NDUFA10
is: SBO:0000252
has only substance units: false

metaM 6pgc r
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:58759
is: HMDB01316
constant: false
initial amount: NaN
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
name: 6-phosphonatooxy-D-gluconate

metaM gly x
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
name: glycine
is: HMDB00123
is: CHEBI:15428
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false

metaM chol m
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00097
is: SBO:0000247
type: Species
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
boundary condition: false
name: choline
is: CHEBI:15354
initial amount: NaN

metaM cholcoa c
boundary condition: false
is: CHEBI:57373
initial concentration: 1.0
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
has only substance units: false
name: choloyl-CoA(4-)
is: HMDB01374
initial amount: NaN
is: SBO:0000247
type: Species
constant: false

metaR SARCStm
reversible: false
is: SBO:0000185
name: Sarcosine transport (mitochondrial)
type: Reaction
kinetic law: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
is described by: ECO:0000000
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_8bd08346_1d6b_478d_8a36_14677ef47ad6
initial concentration: NaN
initial amount: NaN
is: P19634
name: SLC9A1
has only substance units: false
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:6548
boundary condition: true

metaM crm hs g
name: N-acylsphingosine
constant: false
initial concentration: 1.0
is: CHEBI:52639
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN

metaR HMGCOARc
reactant: MODEL1310110003#
is described by: ECO:0000134
fast: false
product: MODEL1310110003#
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.1.34
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
type: Reaction
reversible: false
is: SBO:0000176

metaR DHCR72r
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.21
product: MODEL1310110003#
reactant: MODEL1310110003#
name: 7-dehydrocholesterol reductase
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
modifier: MODEL1310110003#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_a5ba3e32_18bc_40be_b86d_0e27f1ed4885
constant: false
has only substance units: false
boundary condition: true
is: P18405
is encoded by: hsa:6715
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
name: SRD5A1

metaM so4 m
is: CHEBI:16189
name: sulfate
is: HMDB01448
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
initial concentration: 1.0
is: SBO:0000247

metaR G14T7g
type: Reaction
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

http://identifiers.org/biomodels.db/MODEL1310110003#_fbcfd60c_3009_4988_b407_16d2b099b7f0
is: SBO:0000252
is encoded by: hsa:6566
name: SLC16A1
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: B4DKS0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_574695c2_f99a_45ba_bad9_e60761b736ff
initial concentration: NaN
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6547
constant: false
boundary condition: true
name: SLC8A3
is: Q96QG2

metaM 10fthf7glu e
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:57454
constant: false
notes: FORMULA: C50H57N13O25 CHARGE: -8
name: 10-formyltetrahydrofolate-[Glu](7)
is: HMDB00972

http://identifiers.org/biomodels.db/MODEL1310110003#_b719034c_cb14_4c53_b0a4_ffdeae8b35ee
has only substance units: false
name: DGAT1
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: O75907
is encoded by: hsa:8694
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110003#_e0315aa3_47e8_48f7_84af_0a77f86769d5
has only substance units: false
constant: false
type: Species
is: Q99643
name: SDHC
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6391
boundary condition: true

metaM ac c
boundary condition: false
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
has only substance units: false
initial concentration: 1.0
name: acetate
type: Species
is: HMDB00042
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:30089

http://identifiers.org/biomodels.db/MODEL1310110003#_7ece79f6_8963_4223_909b_7d29db16ca36
constant: false
is encoded by: hsa:51
name: ACOX1
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is: B4DK61
initial concentration: NaN
type: Species

metaR MI13PP
reversible: false
name: inositol-1,3-bisphosphate 3-phosphatase
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110003#_f36cc401_4988_4db6_a67a_b9e6d4c1bb0f
is: P56181
is encoded by: hsa:4731
name: NDUFV3
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaM 1pyr5c m
name: 1-Pyrroline-5-carboxylate
is: C03912
is: HMDB01301
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
is: CHEBI:15893

http://identifiers.org/biomodels.db/MODEL1310110003#_5811e90f_e145_4a0d_b9d8_57fe73f2a0e8
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:155184
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q6PXP3
name: SLC2A7

metaR NACDe
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaR PEt
fast: false
kinetic law: MODEL1310110003#
is described by: ECO:0000000
reactant: MODEL1310110003#
name: phosphatidylethanolamine transport
product: MODEL1310110003#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:

metaM pail45p hs c
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
type: Species
boundary condition: false
is: SBO:0000247
name: phosphatidylinositol 4,5-bisphosphate
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28910
has only substance units: false
constant: false

metaM h2o e
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: SBO:0000247
initial amount: NaN
is: CHEBI:15377
name: H2O
boundary condition: false
has only substance units: false
is: C00001
constant: false
type: Species
initial concentration: 1.0
is: HMDB02111

metaM nicrns c
initial amount: NaN
type: Species
is: HMDB06809
initial concentration: 1.0
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841
is: CHEBI:58527
has only substance units: false
name: Nicotinate D-ribonucleoside
constant: false
is: SBO:0000247
boundary condition: false

metaR RE1845X
name: RE1845
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 1 h[c] from compEHMN reaction as they were not necessary
reversible: true
fast: false
type: Reaction
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.65
reactant: MODEL1310110003#
is: SBO:0000176
product: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_10f50a65_67f5_4e25_828a_a8ad8835a0e6
is: SBO:0000252
name: UGT1A8
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
constant: false
is: Q5DSZ6
has only substance units: false
is encoded by: hsa:54576

metaR RDH3a
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.1.105
is version of: http://identifiers.org/ec-code/1.1.1.300
is described by: ECO:0000269
reversible: true
is: SBO:0000176
name: retinol dehydrogenase (11-cis,NADPH)
type: Reaction
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
modifier: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#

metaM acmana c
initial amount: NaN
is: HMDB01129
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
name: N-acetyl-D-mannosamine
initial concentration: 1.0
type: Species
is: CHEBI:17122
constant: false

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR N2M2NMASNtly
name: n2m2nmasn transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reversible: false
product: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
is described by: ECO:0000000

metaM ksi pre12 g
is: C00130
has only substance units: false
is: CHEBI:58053
boundary condition: false
initial concentration: 1.0
is: HMDB00175
initial amount: NaN
constant: false
type: Species
name: keratan sulfate I biosynthesis, precursor 12
notes: FORMULA: C135H218N9O106S3X CHARGE: -4
is: SBO:0000247

metaR PETOHMr hs
product: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
name: phosphatidylethanolamine N-methyltransferase
is version of: http://identifiers.org/ec-code/2.1.1.17
reactant: MODEL1310110003#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ
modifier: MODEL1310110003#
is described by: ECO:0000254
fast: false

metaM xu5p D c
has only substance units: false
name: D-xylulose 5-phosphate(2-)
initial concentration: 1.0
is: CHEBI:57737
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
is: HMDB00868
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_2ae5a9c9_4108_4616_bff9_ad899cc8d04a
is encoded by: hsa:3706
name: ITPKA
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: P23677
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_c76825bb_dfe2_4b76_aae5_91cfe75c2019
name: HADHA
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:3030
constant: false
has only substance units: false
is: E9KL44
initial concentration: NaN

metaR GLYt2r
reversible: true
modifier: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
is described by: ECO:0000304
product: MODEL1310110003#
name: glycine reversible transport via proton symport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110003#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_171438b3_4fd1_4c27_92d9_791729ecbbc5
is encoded by: hsa:M68895
name: _M68895_1_c
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN

metaM nad m
is: SBO:0000247
is: CHEBI:57540
has only substance units: false
name: Nicotinamide adenine dinucleotide
is: http://identifiers.org/pubchem.compound/3305
initial amount: NaN
constant: false
is: HMDB00902
is: C00003
type: Species
initial concentration: 1.0
boundary condition: false

metaM adp x
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
is: HMDB01341
is: CHEBI:456216
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
name: ADP(3-)

http://identifiers.org/biomodels.db/MODEL1310110003#_97175608_ff09_4c5e_8c39_ba6a22e38a05
is: P49327
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:2194
name: FASN
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM cdp e
constant: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:58069
is: SBO:0000247
type: Species
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial amount: NaN
name: CDP(3-)
has only substance units: false
is: HMDB01546

metaR LYStiDF
fast: false
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (6541.1) or (6542.1) or (55089.1) or (84889.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754,PMID:11591158,PMID:11891586,PMID:12049641,PMID:1348489,PMID:14770310,PMID:7534987,PMID:8954799 NOTES:SAB
name: L-lysine transport via diffusion (extracellular to cytosol)
product: MODEL1310110003#
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
reversible: false
reactant: MODEL1310110003#

metaR GALASE19ly
modifier: MODEL1310110003#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000269
product: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
reactant: MODEL1310110003#

metaR PI4PLCn
fast: false
reactant: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (23236.2) or (23236.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10760467,PMID:11118617,PMID:12213492 NOTES:NCD
reversible: false
name: phosphatidylinositol 4-phosphate phospholipase C, nucleus
kinetic law: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
is described by: ECO:0000269

metaR SIAT9g
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110003#
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
type: Reaction
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/2.4.99.9
modifier: MODEL1310110003#
reactant: MODEL1310110003#
reversible: false

metaM h2o g
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
constant: false
initial concentration: 1.0
name: water
has only substance units: false
is: HMDB02111
boundary condition: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_ac640d45_e1e8_442b_9015_d49ea899a486
type: Species
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: P00918
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:760
name: CA2

metaM 25aics c
type: Species
boundary condition: false
has only substance units: false
is: C04823
initial amount: NaN
is: CHEBI:58443
is: HMDB00797
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM leu L e
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
name: L-leucine
has only substance units: false
is: HMDB00687
initial concentration: 1.0
is: CHEBI:15603

metaR DALAOXx
is version of: http://identifiers.org/ec-code/1.4.3.3
reactant: MODEL1310110003#
type: Reaction
name: D-Alanine Oxidase (x)
product: MODEL1310110003#
fast: false
is: SBO:0000176
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (1610.1) SUBSYSTEM: D-alanine metabolism EC Number: 1.4.3.3 Confidence Level: 4 AUTHORS: PMID:9153402 NOTES:SAB
is described by: ECO:0000269
kinetic law: MODEL1310110003#
reversible: false

metaR GHMT2r
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.1.2.1
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110003#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
modifier: MODEL1310110003#
name: glycine hydroxymethyltransferase, reversible
reactant: MODEL1310110003#
fast: false

metaR PCHOLPr hs
name: choline phosphatase
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
modifier: MODEL1310110003#
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
reversible: false
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.4.4

metaR r1540
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
reversible: false
is version of: http://identifiers.org/ec-code/1.17.4.1
reactant: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110003#

metaR EX 34hpp
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaR EX aicar LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
type: Reaction

metaM so4 l
is: SBO:0000247
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false
name: sulfate
type: Species
is: HMDB01448
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:16189

http://identifiers.org/biomodels.db/MODEL1310110003#_c7d1e6ce_5ead_4cdf_b083_5e5a9d7c6798
name: RPIA
is: P49247
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:22934
constant: false
type: Species
initial concentration: NaN
has only substance units: false

metaM dgtp n
is: C00286
is: HMDB01440
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:16497
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
name: dGTP
boundary condition: false

metaR GCC2bim
is version of: http://identifiers.org/ec-code/1.8.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
modifier: MODEL1310110003#
reversible: false
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
kinetic law: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false

metaM tdchola c
type: Species
is: CHEBI:9407
name: taurochenodeoxycholate
is: SBO:0000247
boundary condition: false
is: HMDB00951
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

metaR PPItm
reactant: MODEL1310110003#
name: diphopshate transporter, mitochondrial
type: Reaction
reversible: true
is described by: ECO:0000134
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_1d4c82d1_14b3_499a_96f5_dccc935e357b
has only substance units: false
name: _J03866_1_m
constant: false
is: SBO:0000252
is encoded by: hsa:J03866
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_5705837c_1928_4ec6_bd9e_2cd2c343fd71
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is: O00217
name: NDUFS8
is encoded by: hsa:4728
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_7acbd694_c94e_458a_b884_c15405077374
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is: B7Z3W8
is encoded by: hsa:6536
initial amount: NaN
initial concentration: NaN
name: SLC6A9
type: Species

metaM pap c
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00061
boundary condition: false
is: CHEBI:58343
constant: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: SBO:0000247
initial concentration: 1.0
name: adenosine 3',5'-bismonophosphate(4-)

metaM chol r
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
name: choline
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: CHEBI:15354
has only substance units: false
is: HMDB00097
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_343dd771_ade0_4a00_bbe1_80f708861789
name: SLC2A11
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:66035
initial concentration: NaN
is: Q8WXF9
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_93068aa9_9e42_4369_8356_b3e0d00b7f85
type: Species
boundary condition: true
constant: false
is: Q8NCG5
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:10164
name: CHST4
initial amount: NaN

metaM g3p c
is: http://identifiers.org/pubchem.compound/3930
is: C00661
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
is: CHEBI:58027
type: Species
name: Glyceraldehyde 3-phosphate
constant: false
is: HMDB01112
boundary condition: false
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_c9f45197_8e55_4c04_a219_794a008677b4
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:10455
type: Species
name: ECI2
is: O75521
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_deb34511_6aeb_48ed_9322_b6347f90b23e
boundary condition: true
initial concentration: NaN
name: TKT
type: Species
is encoded by: hsa:7086
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: E7EPA7

metaM HC02210 e
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
type: Species
name: prostaglandin-d3
constant: false
is: CHEBI:34939
has only substance units: false
is: SBO:0000247

metaM dhap c
has only substance units: false
is: SBO:0000247
is: CHEBI:57642
is: C00111
name: Dihydroxyacetone phosphate
initial amount: NaN
type: Species
constant: false
boundary condition: false
is: HMDB01473
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3411

metaR RE1531M
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.17
is described by: ECO:0000000
kinetic law: MODEL1310110003#
name: RE1531
product: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
fast: false
is: SBO:0000176

metaR 10FTHFtm
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion
kinetic law: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
fast: false
is described by: ECO:0000000
is: SBO:0000185

metaR NAt3 1
fast: false
kinetic law: MODEL1310110003#
type: Reaction
reversible: true
modifier: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
reactant: MODEL1310110003#
product: MODEL1310110003#
name: sodium proton antiporter (H:NA is 1:1)
is described by: ECO:0000269

metaR TCYNTt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
type: Reaction
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: false
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110003#
fast: false
name: Thiocyanate transport via diffusion (cytosol to extracellular)

metaR AACOAT
fast: false
kinetic law: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
name: Acetoacetyl-CoA:acetate CoA-transferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (65985.1) SUBSYSTEM: Propanoate metabolism EC Number: 6.2.1.16 Confidence Level: 4 AUTHORS: PMID:12623130 NOTES:also EC 2.8.3.8 NCD
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/6.2.1.16
is described by: ECO:0000269
reactant: MODEL1310110003#
reversible: true

metaR SERGLNexR
is: SBO:0000185
is described by: ECO:0000304
fast: false
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
name: L-Serine/Glutamine reversible exchange

http://identifiers.org/biomodels.db/MODEL1310110003#_803fab11_0d38_4718_9995_9e9f2eba5b67
boundary condition: true
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:5091
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: PC

http://identifiers.org/biomodels.db/MODEL1310110003#_e90e152e_d04a_4ac7_9b7c_ac6a206d4441
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: PIP5K1A
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:8394
is: Q99755

http://identifiers.org/biomodels.db/MODEL1310110003#_1c4e2611_200d_407e_b950_543249b27e01
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
is: P07864
has only substance units: false
constant: false
is encoded by: hsa:3948
boundary condition: true
name: LDHC

metaM cdp c
is: C00112
is: HMDB01546
type: Species
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
constant: false
is: CHEBI:58069
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: CDP

metaM leu L c
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: L-leucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
constant: false
type: Species
is: HMDB00687
is: CHEBI:15603
boundary condition: false

metaM thp2c c
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
initial concentration: 1.0
is: HMDB12130
constant: false
name: 1-piperideine-6-carboxylate
has only substance units: false
boundary condition: false
is: CHEBI:16987

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR r0317
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
modifier: MODEL1310110003#
is: SBO:0000176
type: Reaction
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is version of: http://identifiers.org/ec-code/1.4.4.2
product: MODEL1310110003#
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false

metaR RADH
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
kinetic law: MODEL1310110003#
name: retinal dehydrogenase
type: Reaction
product: MODEL1310110003#
reactant: MODEL1310110003#
reversible: true
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110003#_ff4bf886_8df2_48e4_8588_e29bd7b1f884
initial concentration: NaN
initial amount: NaN
name: SOD1
constant: false
type: Species
is encoded by: hsa:6647
has only substance units: false
boundary condition: true
is: P00441
is: SBO:0000252

metaR ALASm
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD
fast: false
reactant: MODEL1310110003#
modifier: MODEL1310110003#
product: MODEL1310110003#
is described by: ECO:0000254
name: 5-aminolevulinate synthase
is version of: http://identifiers.org/ec-code/2.3.1.29
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.37
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110003#_b1f2a444_e459_4514_a8e6_125172067f91
type: Species
initial concentration: NaN
name: ALG3
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:10195
initial amount: NaN

metaM 2c23dh56dhoxin c
name: 2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C05604
type: Species
is: HMDB04067
notes: FORMULA: C9H8NO4 CHARGE: -1 INCHI: InChI=1/C9H9NO4/c11-7-2-4-1-6(9(13)14)10-5(4)3-8(7)12/h2-3,6,10-12H,1H2,(H,13,14)/t6-/m0/s1 EHMN_ABBREVIATION: C05604
boundary condition: false
is: http://identifiers.org/pubchem.compound/7927
is: SBO:0000247

metaR Ser Thrtg
name: Ser/Thr transport (from golgi to lysosome)
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_d15ad7ff_4c0f_4bc8_9a0d_ec5a47cab313
boundary condition: true
is encoded by: hsa:AI824319
has only substance units: false
name: _AI824319_1_r
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false

metaM fgam c
constant: false
is: SBO:0000247
is: C04376
is: HMDB01308
has only substance units: false
initial amount: NaN
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
initial concentration: 1.0
type: Species
is: CHEBI:58426
boundary condition: false

metaR PGCD
reactant: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
name: phosphoglycerate dehydrogenase
type: Reaction
kinetic law: MODEL1310110003#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.95
is: SBO:0000176
modifier: MODEL1310110003#
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110003#_a5319afb_b086_4001_9bb8_2a921cd6f203
constant: false
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5625
name: PRODH
is: O43272
initial amount: NaN

metaM tdchola e
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
boundary condition: false
is: CHEBI:9407
type: Species
has only substance units: false
name: taurochenodeoxycholate
initial amount: NaN
is: SBO:0000247
is: HMDB00951
initial concentration: 1.0
constant: false

metaR SRTNtu
fast: false
is described by: ECO:0000269
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true
is: SBO:0000185
name: Serotonin uniport
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_25bb7326_8153_4b14_ba55_57293054578f
is: SBO:0000252
type: Species
boundary condition: true
name: ENTPD8
constant: false
initial amount: NaN
is: Q5MY95
initial concentration: NaN
has only substance units: false
is encoded by: hsa:377841

metaM ksi pre23 g
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:28067
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
boundary condition: false
has only substance units: false
type: Species
name: keratan sulfate I biosynthesis, precursor 23

metaR H2O2tp
name: hydrogen peroxide peroxisomal transport via diffusion
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
kinetic law: MODEL1310110003#
fast: false
product: MODEL1310110003#
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_4d5baec0_4374_48b0_9bbf_3a9d0338efee
has only substance units: false
type: Species
name: _AI915649_1_c
is encoded by: hsa:AI915649
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaM fpram c
is: HMDB06211
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
type: Species
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
initial amount: NaN
is: C04640
has only substance units: false
initial concentration: 1.0
is: CHEBI:58478
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_61a7f8ab_a620_4a29_91bd_cd96c235d590
name: DGKI
is: O75912
is encoded by: hsa:9162
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_a8fed5c6_e2b3_455e_8f38_041c5b5e611a
boundary condition: true
initial concentration: NaN
has only substance units: false
is: P19174
constant: false
name: PLCG1
is: SBO:0000252
is encoded by: hsa:5335
type: Species
initial amount: NaN

metaR ORPT
reactant: MODEL1310110003#
reversible: true
product: MODEL1310110003#
type: Reaction
name: orotate phosphoribosyltransferase
kinetic law: MODEL1310110003#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.10
modifier: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_d22484f8_5661_4a62_bd4d_5b1d9fa507cf
has only substance units: false
boundary condition: true
is: P31213
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: SRD5A2
constant: false
is encoded by: hsa:6716

http://identifiers.org/biomodels.db/MODEL1310110003#_62d9c083_66f8_4528_a139_4f3b635969e1
has part: P07195
initial amount: NaN
initial concentration: NaN
name: LDHA:LDHB
type: Species
is: SBO:0000297
is encoded by: hsa:3945
has only substance units: false
is encoded by: hsa:3939
boundary condition: true
constant: false
has part: P00338

http://identifiers.org/biomodels.db/MODEL1310110003#_405c2c9b_74e5_41b7_b11b_e538189a9ad1
is: F5H066
initial concentration: NaN
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6560
constant: false
name: SLC12A4

metaR Q10H2e
reversible: true
product: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
is described by: ECO:0000134
is: SBO:0000185
name: transport of ubiquinol into lymph
fast: false
reactant: MODEL1310110003#

metaM dhap e
is: CHEBI:57642
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: glycerone phosphate(2-)
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
constant: false
type: Species
has only substance units: false
is: HMDB01473
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_8435ec64_6c59_453b_a707_dd39580e7d1d
boundary condition: true
is: SBO:0000252
name: COX6B1
initial concentration: NaN
is: P14854
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:1340

metaR HAtly
reversible: false
reactant: MODEL1310110003#
product: MODEL1310110003#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
name: hyaluronan transport, extracellular to lysosome
fast: false
kinetic law: MODEL1310110003#

http://identifiers.org/biomodels.db/MODEL1310110003#_fc28129d_7efa_4dac_ba3e_ad3721f60c30
has only substance units: false
is encoded by: hsa:55343
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
is: B3KQH0
boundary condition: true
name: SLC35C1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_4e757e1c_c5cf_4ae1_a57e_b3bd8895700f
is encoded by: hsa:4952
boundary condition: true
has only substance units: false
name: OCRL
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
initial amount: NaN

metaM ac e
type: Species
is: HMDB00042
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: CHEBI:30089
name: acetate
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_e0c9d03c_23c0_4f8c_a409_442c13bd177b
type: Species
is: O43451
initial concentration: NaN
is encoded by: hsa:8972
name: MGAM
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN

metaM c226crn c
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/127055
boundary condition: false
name: cervonyl carnitine
is: HMDB06510

metaM xoldiolone r
type: Species
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
constant: false
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28477
is: HMDB02197
has only substance units: false
is: SBO:0000247

metaR THYMDtm
fast: false
kinetic law: MODEL1310110003#
name: thymd transport
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:TDV
modifier: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#

metaR PRASCS
kinetic law: MODEL1310110003#
is: SBO:0000176
modifier: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/6.3.2.6
product: MODEL1310110003#
reversible: true
fast: false
is described by: ECO:0000269

metaR 34DHPLACOX
reactant: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 3,4-Dihydroxyphenylacetaldehyde:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (218.1) or (222.1) or (220.1) or (221.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:11306106,PMID:2071588 NOTES:SAB
product: MODEL1310110003#
fast: false
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110003#

metaR DNDPt28m
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dCDP transport via dGDP antiport
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110003#
fast: false

metaM m8masn r
type: Species
has only substance units: false
is: SBO:0000247
is: C05876
initial concentration: 1.0
notes: FORMULA: C70H117N2O55X CHARGE: 0
initial amount: NaN
boundary condition: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
constant: false

metaR H2O2tn
is described by: ECO:0000000
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
reversible: true
fast: false
product: MODEL1310110003#
name: hydrogen peroxide nuclear transport
is: SBO:0000185

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_17e87e57_6158_4088_a33f_5cdab159882f
is: SBO:0000252
constant: false
name: _F23536_1_m
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:F23536

metaM h2o l
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: water
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:15377

metaM fad m
is: CHEBI:16238
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: C00016
is: HMDB01248
constant: false
name: Flavin adenine dinucleotide oxidized

metaM hs deg8 l
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
is: CHEBI:16126
constant: false
initial concentration: 1.0
name: heparan sulfate, degradation product 8
is: SBO:0000247
has only substance units: false

metaM hista e
is: HMDB00870
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: CHEBI:58432
boundary condition: false
name: histamium
initial concentration: 1.0
is: SBO:0000247
type: Species

metaM HC01162 c
is: SBO:0000247
is: CHEBI:58376
has only substance units: false
boundary condition: false
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false

metaR FRDPtr
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
reactant: MODEL1310110003#
name: lipid, flip-flop intracellular transport
product: MODEL1310110003#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110003#
fast: false

metaR r0669
type: Reaction
is described by: ECO:0000000
product: MODEL1310110003#
fast: false
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
reversible: false
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17

metaR r0774
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110003#
product: MODEL1310110003#
fast: false
type: Reaction
kinetic law: MODEL1310110003#
is: SBO:0000176
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.107
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:

metaM HC01223 m
is: CHEBI:57340
is: SBO:0000247
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaR 3MOX4HOXPGALDOX NADP
modifier: MODEL1310110003#
type: Reaction
is: SBO:0000176
is described by: ECO:0000304
product: MODEL1310110003#
fast: false
kinetic law: MODEL1310110003#
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 3-Methoxy-4-hydroxyphenylglycolaldehyde:NADP+ oxidoreductase
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: NOTES:SAB
reactant: MODEL1310110003#

metaR r1492
kinetic law: MODEL1310110003#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
product: MODEL1310110003#
reactant: MODEL1310110003#
name: Utilized transport
is: SBO:0000185
reversible: false
fast: false
type: Reaction

metaR RE3244R
product: MODEL1310110003#
modifier: MODEL1310110003#
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110003#
fast: false
name: RE3244
is: SBO:0000176
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110003#_9db177dc_5bac_48f3_8e7d_e308db5c6fdf
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:AA526438
boundary condition: true
name: _AA526438_1_m

metaM gm3 hs g
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:60065
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
type: Species
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM frdp r
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
name: Farnesyl diphosphate
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: HMDB00961
is: CHEBI:175763
type: Species
initial amount: NaN
boundary condition: false
is: C00448

http://identifiers.org/biomodels.db/MODEL1310110003#_250800e1_36d2_44b4_9e46_16ea5496eba9
has only substance units: false
type: Species
is: SBO:0000252
constant: false
is: Q15392
boundary condition: true
name: DHCR24
is encoded by: hsa:1718
initial amount: NaN
initial concentration: NaN

metaR GLYt7 311 r
product: MODEL1310110003#
type: Reaction
reactant: MODEL1310110003#
modifier: MODEL1310110003#
fast: false
is described by: ECO:0000006
kinetic law: MODEL1310110003#
reversible: true
name: glycine reversible transport via sodium and chloride symport (3:1:1)
is: SBO:0000185
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB

metaR O2tp
product: MODEL1310110003#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
fast: false
reversible: true
is described by: ECO:0000000
name: O2 transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaM HC02192 c
notes: FORMULA: C26H44NO5S CHARGE: -1 INCHI: InChI=1S/C26H45NO5S/c1-17(4-9-24(29)27-14-15-33(30,31)32)21-7-8-22-20-6-5-18-16-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3/h17-23,28H,4-16H2,1-3H3,(H,27,29)(H,30,31,32)/p-1/t17-,18-,19-,20+,21-,22+,23+,25+,26-/m1/s1 EHMN_ABBREVIATION: C02592
name: taurolithocholate
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:17179

metaM paps g
constant: false
initial amount: NaN
boundary condition: false
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
type: Species
has only substance units: false
is: CHEBI:58339
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: HMDB01134
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_1c2d7e09_03e2_4c19_9865_e80e2f38b042
type: Species
is encoded by: hsa:56606
is: Q9NRM0
name: SLC2A9
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110003#_65c0e27b_9a1d_41cb_8ce7_8d1220bc6d52
is: SBO:0000252
constant: false
name: RHAG
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6005
type: Species
is: Q96E98
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_7b0f1ab6_c1aa_44e7_a5c8_25a1a68b81eb
type: Species
is: Q9BRC7
constant: false
is encoded by: hsa:84812
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: PLCD4
boundary condition: true
is: SBO:0000252

metaM val L e
name: L-valine
boundary condition: false
initial concentration: 1.0
is: HMDB00883
is: CHEBI:16414
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_93dfd234_305f_47cf_8eed_2639d80bc7d5
initial concentration: NaN
name: AK5
type: Species
has only substance units: false
is encoded by: hsa:26289
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaR ICDHyrm
modifier: MODEL1310110003#
name: Isocitrate dehydrogenase (NADP+)
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
product: MODEL1310110003#
reactant: MODEL1310110003#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.42
fast: false
is: SBO:0000176
is described by: ECO:0000269

metaR DGCHOLte
is described by: ECO:0000000
fast: false
reversible: true
reactant: MODEL1310110003#
is: SBO:0000185
name: bile acid intracellular transport
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaR NCAMUP
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
is: SBO:0000185
fast: false
name: Nicotinamide acid uptake
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
product: MODEL1310110003#
type: Reaction

metaM o2 m
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15379
name: O2
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB01377
is: C00007
type: Species
has only substance units: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

http://identifiers.org/biomodels.db/MODEL1310110003#_9ca8f6a1_681c_44f6_b4c1_2eeabb97c7cb
type: Species
constant: false
initial concentration: NaN
name: _AI091231_1_c
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:AI091231
initial amount: NaN

metaM hista c
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: histamium
initial concentration: 1.0
is: CHEBI:58432
type: Species
constant: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: HMDB00870
boundary condition: false

metaR DURIt
reactant: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
name: deoxyuridine transport via diffusion
kinetic law: MODEL1310110003#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
is described by: ECO:0000000
fast: false

metaM oxa m
is: HMDB02329
is: CHEBI:30623
is: SBO:0000247
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
name: oxalate(2-)
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110003#_b5db8dae_ac5c_4844_b037_5056f9794726
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
name: HADHB
has only substance units: false
is encoded by: hsa:3032
constant: false
initial concentration: NaN
is: P55084

metaR r0870
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.4
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.7.7.72
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110003#
name: Facilitated diffusion
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
reactant: MODEL1310110003#
is version of: http://identifiers.org/ec-code/3.6.4.13
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110003#
product: MODEL1310110003#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_5a1aeb16_9651_4976_8dcb_8d57b429fe3e
constant: false
name: NUDT12
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:83594
initial concentration: NaN
is: Q9BQG2
initial amount: NaN

metaR NDPK6n
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
modifier: MODEL1310110003#
is: SBO:0000176
kinetic law: MODEL1310110003#
is described by: ECO:0000304
reactant: MODEL1310110003#
product: MODEL1310110003#
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear

metaR RE1254C
product: MODEL1310110003#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
kinetic law: MODEL1310110003#
reversible: true
is: SBO:0000176
name: RE1254
reactant: MODEL1310110003#
is described by: ECO:0000000

metaM air c
constant: false
is: CHEBI:58592
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01235
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
is: C03373
type: Species
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_3d0a3228_1d97_40b9_8f07_588671667735
boundary condition: true
name: DPM3:DPM1:DPM2
is encoded by: hsa:8818
has part: O60762
has part: O94777
constant: false
has only substance units: false
is encoded by: hsa:8813
type: Species
is: SBO:0000297
is encoded by: hsa:54344
initial concentration: NaN
has part: Q86TM7
initial amount: NaN

metaM lnlncgcoa c
is: HMDB06368
has only substance units: false
name: gamma-linolenoyl-CoA(4-)
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57363
is: SBO:0000247
boundary condition: false
constant: false
type: Species
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035

metaR FAOXC204
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110003#
reactant: MODEL1310110003#
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
product: MODEL1310110003#
is: SBO:0000176

metaR UMPK4n
kinetic law: MODEL1310110003#
modifier: MODEL1310110003#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110003#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
name: UMP kinase (GTP),nuclear
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110003#

metaM udp r
has only substance units: false
name: UDP
type: Species
is: C00015
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58223
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
constant: false

metaR r1559
fast: false
product: MODEL1310110003#
type: Reaction
kinetic law: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_b7c68ddd_2d1a_4841_a33c_b32b442cae7b
type: Species
initial amount: NaN
is encoded by: hsa:8671
is: A5JJ20
name: SLC4A4
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
constant: false

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaM his L m
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
name: L-histidine
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971
is: HMDB00177

http://identifiers.org/biomodels.db/MODEL1310110003#_72052560_6cc1_4356_88bd_e6ad275c67d9
has only substance units: false
is: SBO:0000252
is: Q9Y5P4
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:10087
type: Species
constant: false
boundary condition: true
name: COL4A3BP

metaM o2 n
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:15379
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
initial amount: NaN
name: dioxygen

metaR r0668
reactant: MODEL1310110003#
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
type: Reaction
is described by: ECO:0000000
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
reversible: true
is version of: http://identifiers.org/ec-code/2.4.2.19
is: SBO:0000176
fast: false
product: MODEL1310110003#
modifier: MODEL1310110003#

metaR PHEACGLNt
product: MODEL1310110003#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
kinetic law: MODEL1310110003#
name: PHEACGLN extracellular transport via diffusion
fast: false
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110003#

metaR r0527
product: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_94aa6977_87d6_43f9_aabb_128abecdf511
has only substance units: false
is encoded by: hsa:79053
is: SBO:0000252
name: ALG8
initial amount: NaN
is: Q9BVK2
initial concentration: NaN
boundary condition: true
constant: false
type: Species

metaR O2tn
reversible: true
is described by: ECO:0000000
name: O2 nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
type: Reaction
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000185
reactant: MODEL1310110003#

metaM HC02192 e
notes: FORMULA: C26H44NO5S CHARGE: -1 INCHI: InChI=1S/C26H45NO5S/c1-17(4-9-24(29)27-14-15-33(30,31)32)21-7-8-22-20-6-5-18-16-19(28)10-12-25(18,2)23(20)11-13-26(21,22)3/h17-23,28H,4-16H2,1-3H3,(H,27,29)(H,30,31,32)/p-1/t17-,18-,19-,20+,21-,22+,23+,25+,26-/m1/s1 EHMN_ABBREVIATION: C02592
initial amount: NaN
name: taurolithocholate
type: Species
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:17179
initial concentration: 1.0
has only substance units: false

metaR CYTK1n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reactant: MODEL1310110003#
type: Reaction
product: MODEL1310110003#
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
is: SBO:0000176
name: cytidylate kinase (CMP),nuclear
reversible: true
modifier: MODEL1310110003#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_78547033_9586_4ea5_aef9_fcf600410018
name: PYCR2
initial amount: NaN
is: Q96C36
initial concentration: NaN
type: Species
is: SBO:0000252
is encoded by: hsa:29920
constant: false
has only substance units: false
boundary condition: true

metaR NDPK6m
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
reactant: MODEL1310110003#
product: MODEL1310110003#
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
reversible: true
modifier: MODEL1310110003#
is: SBO:0000176
fast: false
is described by: ECO:0000254

metaR S6T7g
product: MODEL1310110003#
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
modifier: MODEL1310110003#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaM 5pmev c
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: (R)-5-phosphonatomevalonate(3-)
constant: false
is: HMDB01343
notes: FORMULA: C6H10O7P CHARGE: -3 INCHI: InChI=1S/C6H13O7P/c1-6(9,4-5(7)8)2-3-13-14(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12)/p-3/t6-/m1/s1
type: Species
initial concentration: 1.0
has only substance units: false

metaR H2Otg
name: H2O transport, Golgi apparatus
product: MODEL1310110003#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110003#
fast: false

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR NDPK6
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110003#
name: Nucleoside-diphosphate kinase (ATP:dUDP)
product: MODEL1310110003#
is: SBO:0000176
reversible: true
reactant: MODEL1310110003#
fast: false
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269

metaM ru5p D r
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:58121
initial concentration: 1.0
type: Species
initial amount: NaN
name: D-ribulose 5-phosphate(2-)
is: HMDB00618
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188

metaR RE0577C
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110003#
product: MODEL1310110003#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
is version of: http://identifiers.org/ec-code/3.1.2.2
type: Reaction
name: RE0577
modifier: MODEL1310110003#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
reactant: MODEL1310110003#

metaM taur e
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:3544
has only substance units: false
is: C00245
name: Taurine
is: HMDB00251
constant: false
notes: FORMULA: C2H7NO3S CHARGE: 0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110003#_64905dd6_1e20_49d7_a5eb_bec6d0615ce9
boundary condition: true
name: MPI
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4351
is: P34949
initial amount: NaN
has only substance units: false
type: Species

metaM retinol cis 11 c
boundary condition: false
is: HMDB06216
constant: false
type: Species
is: SBO:0000247
is: CHEBI:16302
name: 11-cis-retinol
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110003#_7c0e7fb2_2ba8_458a_9004_08b1d389ab03
initial amount: NaN
type: Species
name: B3GALT5
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
is: Q9Y2C3
has only substance units: false
is encoded by: hsa:10317

metaR G12MT1 U
reactant: MODEL1310110003#
reversible: false
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
product: MODEL1310110003#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_8c06385f_8e92_4bc4_864c_0eb7cef1f42a
is: Q9UBM1
is: SBO:0000252
initial amount: NaN
name: PEMT
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:10400

metaR r1556
fast: false
is: SBO:0000185
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110003#
product: MODEL1310110003#
kinetic law: MODEL1310110003#

metaM ksi pre10 g
is: CHEBI:58053
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
is: HMDB00175
is: C00130
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 10
is: SBO:0000247
constant: false
type: Species
initial amount: NaN

metaR O2tm
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
kinetic law: MODEL1310110003#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
name: O2 transport (diffusion)
fast: false

metaR NDPK5
kinetic law: MODEL1310110003#
product: MODEL1310110003#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110003#
reactant: MODEL1310110003#
fast: false
name: Nucleoside-diphosphate kinase (ATP:dGDP)
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110003#_0181052e_caa8_4ab1_959a_f53ee1246e90
is encoded by: hsa:5330
initial amount: NaN
boundary condition: true
name: PLCB2
has only substance units: false
is: Q59F77
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false

metaR PRISTCOAtcx
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of pristanoylcoa from cytosol to peroxisomes.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_70f0bf17_df68_4192_b658_15568dfabf4f
initial amount: NaN
type: Species
is encoded by: hsa:131
constant: false
boundary condition: true
is: SBO:0000252
name: ADH7
initial concentration: NaN
has only substance units: false
is: P40394

metaR r2420
reactant: MODEL1310110003#
is described by: ECO:0000000
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
product: MODEL1310110003#
kinetic law: MODEL1310110003#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110003#_f12df20f_e5ea_4b02_910f_ec9680989e4d
is: Q5HYI4
is: SBO:0000252
constant: false
is encoded by: hsa:6713
initial concentration: NaN
type: Species
boundary condition: true
name: SQLE
has only substance units: false
initial amount: NaN

metaM HC01399 m
has only substance units: false
boundary condition: false
notes: FORMULA: C35H58N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-24,28-30,34,43,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t23-,24+,28+,29+,30-,34+/m0/s1 EHMN_ABBREVIATION: C05260
is: SBO:0000247
constant: false
is: CHEBI:27466
initial concentration: 1.0
name: (S)-3-Hydroxytetradecanoyl-CoA
type: Species
initial amount: NaN

metaR GLYSARCNc
kinetic law: MODEL1310110003#
product: MODEL1310110003#
reactant: MODEL1310110003#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Hydrolysis of glycylsarcosine for uptake
type: Reaction

metaR RE3006M
modifier: MODEL1310110003#
reversible: true
reactant: MODEL1310110003#
name: RE3006
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110003#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110003#
type: Reaction
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
fast: false

metaR CYTK11n
is: SBO:0000176
reactant: MODEL1310110003#
name: cytidylate kinase (dCMP,dGTP),nuclear
reversible: true
modifier: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110003#
is described by: ECO:0000269
kinetic law: MODEL1310110003#

metaM lanost r
constant: false
name: lanosterol
initial amount: NaN
is: HMDB01251
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
is: CHEBI:16521
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0

metaR r1557
product: MODEL1310110003#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110003#
reactant: MODEL1310110003#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaM accoa c
is: HMDB01206
boundary condition: false
is: C00024
is: CHEBI:57288
initial amount: NaN
initial concentration: 1.0
name: Acetyl-CoA
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species

http://identifiers.org/biomodels.db/MODEL1310110003#_b5ff8889_8180_4a96_93a0_9a4b033163e3
constant: false
is encoded by: hsa:6390
is: P21912
is: SBO:0000252
type: Species
name: SDHB
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

metaR DOLPGT2 Uer
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110003#
product: MODEL1310110003#
modifier: MODEL1310110003#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110003#
is version of: http://identifiers.org/ec-code/2.4.1.265
fast: false

http://identifiers.org/biomodels.db/MODEL1310110003#_4778d8f9_c8ec_4faa_988b_309f5c765e9c
initial amount: NaN
is: P13196
is: SBO:0000252
constant: false
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ALAS1
is encoded by: hsa:211

http://identifiers.org/biomodels.db/MODEL1310110003#_ef868bdb_379f_4e99_8c57_064bcd9f2b1d
constant: false
is: Q86VV3
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:953
boundary condition: true
name: ENTPD1
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110003#_02208882_67d6_40e3_8dc6_e408a5784b3c
name: FOLR1
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2348
boundary condition: true
type: Species
is: SBO:0000252
has only substance units: false

metaM pail hs n
is: CHEBI:57880
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol(1-)
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial concentration: 1.0
type: Species

metaM lnlccrn m
boundary condition: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
name: Linoleyl carnitine
is: HMDB06469
initial amount: NaN
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247