metaM dolglcp U r
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:15812
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
initial concentration: 1.0
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: SBO:0000247

metaM tdcoa m
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:57385
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
is: HMDB01521
type: Species
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: SBO:0000247
initial amount: NaN
is: C02593
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_ae44e2b2_02f5_4960_937b_ecff6774b5b4
name: ETFA:ETFB
constant: false
is: SBO:0000297
boundary condition: true
is encoded by: hsa:2109
has part: P38117
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species

metaM dcmp n
boundary condition: false
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: HMDB01202
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:57566
constant: false
has only substance units: false
name: dCMP(2-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_ea68eee3_1015_46ff_ac81_48c699f0e04a
initial concentration: NaN
name: NOS1
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:4842
is: B4DG68

metaR NDPK5
reversible: true
fast: false
name: Nucleoside-diphosphate kinase (ATP:dGDP)
reactant: MODEL1310110002#
is described by: ECO:0000269
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
modifier: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6

metaR COAtp
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
product: MODEL1310110002#
name: coenzyme A transport, peroxisomal
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_c9d942b3_82e5_48c0_9001_b665671d3fdd
name: HAS3
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:3038
is: Q96RV2

http://identifiers.org/biomodels.db/MODEL1310110002#_e0ca2731_ab37_436e_957a_42c4fd01acb2
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is: Q9Y666
is encoded by: hsa:10723
constant: false
name: SLC12A7
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_ff0d6028_d028_42e8_9f87_71b519ace81a
type: Species
has only substance units: false
constant: false
is encoded by: hsa:471
is: P31939
boundary condition: true
name: ATIC
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR r2102
reactant: MODEL1310110002#
is: SBO:0000185
modifier: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110002#
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_0dc8fa50_7f6d_4007_a277_228dd54a3e7d
has only substance units: false
is encoded by: hsa:8867
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: SYNJ1
is: C9JFZ1
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_2eae7e19_deb0_4e76_a45d_6e033702da72
initial concentration: NaN
boundary condition: true
name: SLC27A1
type: Species
is encoded by: hsa:376497
is: Q6PCB7
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaM gcald c
constant: false
is: CHEBI:17071
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
type: Species
initial amount: NaN
is: HMDB03344
initial concentration: 1.0
name: glycolaldehyde
has only substance units: false
boundary condition: false
is: SBO:0000247

metaM 6pgl c
name: 6-phospho-D-glucono-1,5-lactone
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H9O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
is: C01236
is: HMDB01127
is: CHEBI:57955
type: Species
constant: false

metaR G6PDH2rer
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.47
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
modifier: MODEL1310110002#
is: SBO:0000176

metaR THYOXt2
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
type: Reaction
reversible: true
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110002#
fast: false
name: T4 transport via facilitated diffusion
kinetic law: MODEL1310110002#
product: MODEL1310110002#

metaR MAL Ltx
kinetic law: MODEL1310110002#
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110002#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
name: Transport reaction for malate
is: SBO:0000185
product: MODEL1310110002#

metaR OCOAT1m
is described by: ECO:0000269
type: Reaction
fast: false
reversible: true
product: MODEL1310110002#
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.8.3.5
name: 3-oxoacid CoA-transferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.8.3.5 Confidence Level: 4 AUTHORS: PMID:10964512,PMID:11756565 NOTES:TDV

metaR ITCOALm
is described by: ECO:0000212
modifier: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/6.2.1.5
fast: false
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110002#

metaM dhdascb c
name: dehydroascorbide(1-)
constant: false
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
has only substance units: false
is: CHEBI:58070
is: HMDB01264
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_69092a61_d66e_46f1_945c_74f9a3eeff75
boundary condition: true
is: P16442
type: Species
name: ABO
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:28

metaM ksii core4 pre8 g
name: keratan sulfate II biosynthesis, precursor 8
constant: false
notes: FORMULA: C83H134N7O61SX CHARGE: -2
is: HMDB00175
has only substance units: false
initial amount: NaN
is: C00130
initial concentration: 1.0
boundary condition: false
is: CHEBI:58053
is: SBO:0000247
type: Species

metaM 25aics c
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
is: SBO:0000247
initial concentration: 1.0
is: HMDB00797
is: CHEBI:58443
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
constant: false
is: C04823
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_6f301174_489a_4303_8129_5b98b69c6039
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: ACPP
is: P15309
type: Species
boundary condition: true
constant: false
is encoded by: hsa:55
initial concentration: NaN

metaR NDPK6
kinetic law: MODEL1310110002#
name: Nucleoside-diphosphate kinase (ATP:dUDP)
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110002#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110002#
is described by: ECO:0000269
modifier: MODEL1310110002#
type: Reaction

metaM dhlam m
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: CHEBI:17694
is: HMDB00985
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
name: dihydrolipoamide

metaR ICDHyrm
is described by: ECO:0000269
reactant: MODEL1310110002#
name: Isocitrate dehydrogenase (NADP+)
type: Reaction
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
reversible: true
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110002#_4e33edf5_a07c_4ef1_a4c7_9ca1abbafdc3
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:AA278423
initial concentration: NaN
boundary condition: true
constant: false
type: Species
name: _AA278423_1_m

http://identifiers.org/biomodels.db/MODEL1310110002#_cc337742_1eb4_4a69_902e_e1f33830d58b
is: SBO:0000252
is: P32119
initial amount: NaN
boundary condition: true
has only substance units: false
name: PRDX2
initial concentration: NaN
is encoded by: hsa:7001
constant: false
type: Species

metaR r1400
is described by: ECO:0000000
type: Reaction
name: Active transport
is: SBO:0000185
reactant: MODEL1310110002#
product: MODEL1310110002#
reversible: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
fast: false

metaR r2103
modifier: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
type: Reaction
reversible: true
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_a5f4fa52_4583_45d7_abbb_8486bc00ea80
is: SBO:0000297
boundary condition: true
has part: Q9UBK5
has part: P48736
constant: false
initial concentration: NaN
name: HCST:PIK3CG
is encoded by: hsa:10870
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:5294

http://identifiers.org/biomodels.db/MODEL1310110002#_ad9566cc_1af1_4859_baab_a1fde2ede9a1
is encoded by: hsa:4696
name: NDUFA3
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: O95167
has only substance units: false
initial amount: NaN

metaM gchola e
has only substance units: false
notes: FORMULA: C26H43NO6 CHARGE: 0
type: Species
initial amount: NaN
constant: false
name: glycocholate
boundary condition: false
is: SBO:0000247
is: HMDB00138
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_bc04cc03_e5d9_4d3e_90b5_b7c4c3038c62
is: SBO:0000252
is encoded by: hsa:2538
name: G6PC
type: Species
initial concentration: NaN
constant: false
is: P35575
boundary condition: true
has only substance units: false
initial amount: NaN

metaM atp r
is: HMDB00538
constant: false
is: CHEBI:57299
boundary condition: false
initial concentration: 1.0
type: Species
is: C00002
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: ATP(4-)

metaR DGTPtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID: 16816105, PMID: 17403938. NOTES:
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000185
type: Reaction
product: MODEL1310110002#
fast: false
is described by: ECO:0000134
name: transport of dGTP into mitochondria
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110002#_0df885f2_9d9d_4112_bc99_84153af7a55a
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: AOC2
constant: false
is encoded by: hsa:314

metaR EX no LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for NO
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_541191cf_ef98_41f5_908f_069eed958261
has part: P23378
boundary condition: true
name: DLD:GCSH:GLDC:AMT
type: Species
initial concentration: NaN
has part: P23434
is: SBO:0000297
is encoded by: hsa:2731
is encoded by: hsa:275
has part: P48728
is encoded by: hsa:2653
has only substance units: false
initial amount: NaN
constant: false

metaM pchol hs m
is: CHEBI:16110
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
name: Phosphatidylcholine
boundary condition: false

metaR GSNt
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269
kinetic law: MODEL1310110002#
fast: false
modifier: MODEL1310110002#
is: SBO:0000185
reversible: true
product: MODEL1310110002#
name: guanosine facilated transport in cytosol
reactant: MODEL1310110002#
type: Reaction

metaR NDPK3
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
modifier: MODEL1310110002#
name: nucleoside-diphosphate kinase (ATP:CDP)
kinetic law: MODEL1310110002#
product: MODEL1310110002#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110002#
is described by: ECO:0000269

metaM cmp n
is: CHEBI:60377
is: HMDB00095
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
name: CMP(2-)
constant: false
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR PTCRTD
kinetic law: MODEL1310110002#
type: Reaction
reversible: true
name: diffusion of putriscine into the endothelial cells
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
product: MODEL1310110002#
fast: false
is: SBO:0000185
is described by: ECO:0000134

metaR COAtn
reversible: true
fast: false
kinetic law: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110002#
is: SBO:0000185
reactant: MODEL1310110002#
type: Reaction
name: coenzyme A transport, nuclear

metaR r2100
reversible: true
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000185
fast: false
product: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110002#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_774093d4_1f8d_4b5c_ac02_c6c2a7ca8155
is encoded by: hsa:50484
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: RRM2B
is: SBO:0000252
is: Q7LG56
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_ebbb96d2_8b71_4993_a6f7_8b3a8d28e1a4
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:HG2846-HT2983
type: Species
has only substance units: false
name: _HG2846_HT2983_1_m
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_3697c847_78ff_4db7_8887_c06b4646c505
has only substance units: false
name: GGT1
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is: P19440
is encoded by: hsa:2678
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_998129de_1f33_4660_af17_83e6076465f5
constant: false
initial amount: NaN
is: O60547
boundary condition: true
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: GMDS
type: Species
is encoded by: hsa:2762

metaR r0984
product: MODEL1310110002#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8
is: SBO:0000185
reactant: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
is described by: ECO:0000000

metaM Ser Thr l
name: protein-linked serine or threonine residue (O-glycosylation site)
constant: false
is: CHEBI:58190
boundary condition: false
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: XH CHARGE: 0
is: HMDB00224
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_183e3661_1ad8_4ed3_973f_f89b20d2dde8
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: _H17063_1_c
has only substance units: false
type: Species
is encoded by: hsa:H17063

metaM cholate c
has only substance units: false
is: HMDB00619
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
boundary condition: false
is: SBO:0000247
constant: false
is: CHEBI:29747
initial concentration: 1.0
name: Cholate
type: Species
initial amount: NaN

metaR DDPGAm
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 4.1.2.14 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:14193832,PMID:15849464,PMID:9783918 NOTES:IT rxn is done by 4.1.2.14 and 4.1.3.16 mitochondrial isozyme - NCD
product: MODEL1310110002#
name: 2-dehydro-3-deoxy-phosphogluconate aldolase, mitochondrial
fast: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_addba43c_e25f_4d9e_be14_4e339249f8ee
name: PIK3R5
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:23533
is: Q8WYR1
type: Species
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_0a78fdf6_6ebb_477c_aaf6_0a8754c27d47
is encoded by: hsa:6560
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
name: SLC12A4
constant: false
initial concentration: NaN
is: F5H066
initial amount: NaN

metaR NDPK4
name: nucleoside-diphosphate kinase (ATP:dTDP)
reactant: MODEL1310110002#
is described by: ECO:0000269
kinetic law: MODEL1310110002#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
modifier: MODEL1310110002#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110002#_e142c526_74f9_4c15_bdc8_9169580f8f2a
is: Q9UBM1
has only substance units: false
name: PEMT
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:10400
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_268dfa0c_f333_475e_bedf_3d9cac54bef0
initial amount: NaN
initial concentration: NaN
name: VNN3
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:55350
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_13fda66d_ee20_4e18_9b32_cddc6e0e1c76
name: ADSSL1
is encoded by: hsa:122622
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: Q8N142

metaM co2 m
is: C00011
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
type: Species
is: CHEBI:16526
has only substance units: false
initial amount: NaN
is: HMDB01967
initial concentration: 1.0
name: CO2

metaM cmp m
constant: false
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
boundary condition: false
is: CHEBI:60377
is: HMDB00095
name: CMP(2-)
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR OBDHc
is: SBO:0000176
reactant: MODEL1310110002#
name: 2-Oxobutanoate dehydrogenase, cytosolic
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.7.2 Confidence Level: 2 AUTHORS: NOTES:as shown in Lehninger (4th ed.) for threonine degradation MM
fast: false
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#

metaM ksii core2 pre7 g
name: keratan sulfate II biosynthesis, precursor 7
is: SBO:0000247
is: C00130
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00175
is: CHEBI:58053
boundary condition: false
initial amount: NaN
notes: FORMULA: C67H108N5O51SX CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110002#_05897c04_55e3_4c13_8c05_69153a706216
type: Species
constant: false
is: SBO:0000297
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:5048
name: PAFAH1B1:PAFAH1B2:PAFAH1B3
has part: P43034

http://identifiers.org/biomodels.db/MODEL1310110002#_334362d2_f494_47fa_8726_457de9929342
name: DUT
initial amount: NaN
type: Species
is: P33316
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
is encoded by: hsa:1854
boundary condition: true

metaR LCADi
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
fast: false
product: MODEL1310110002#
is: SBO:0000176
name: lactaldehyde dehydrogenase
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.2.1.36
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110002#
type: Reaction
reversible: false
reactant: MODEL1310110002#

metaM gchola c
is: HMDB00138
name: glycocholate
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:58235
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921

metaR r2101
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR COAtm
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
fast: false
name: CoA transporter
kinetic law: MODEL1310110002#
is: SBO:0000185

metaR CLOXAtex2
fast: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is described by: ECO:0000304
reactant: MODEL1310110002#
modifier: MODEL1310110002#
name: chloride transport via oxalate countertransport (2:1)
type: Reaction
is: SBO:0000185
reversible: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_cd4f4fa9_2029_45e0_93de_cff70993155b
is: Q9H553
constant: false
name: ALG2
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:85365
has only substance units: false

metaM ascb L e
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:38290
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: HMDB00044
name: L-ascorbate
type: Species

metaR UDPGLCter
reactant: MODEL1310110002#
name: UDP-Glc endoplasmic reticulum transport via CMP antiport
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
kinetic law: MODEL1310110002#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_8c07b944_4b99_4528_bc5e_fdc62ab32250
has only substance units: false
type: Species
is: SBO:0000252
constant: false
boundary condition: true
is: Q9GZX3
name: CHST6
initial concentration: NaN
is encoded by: hsa:4166
initial amount: NaN

metaR NADtru
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110002#
reversible: false
name: NAD transporter, endoplasmic reticulum
is: SBO:0000185
reactant: MODEL1310110002#
type: Reaction
fast: false
product: MODEL1310110002#

metaR ATPH1e
type: Reaction
fast: false
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (954.1) or (954.2) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
is described by: ECO:0000269
name: ATP diphosphohydrolase
is version of: http://identifiers.org/ec-code/3.6.1.6
is: SBO:0000176
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.6.1.5
reversible: false
product: MODEL1310110002#

metaR NDPK1
reversible: true
product: MODEL1310110002#
name: nucleoside-diphosphate kinase (ATP:GDP)
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110002#
is described by: ECO:0000134
kinetic law: MODEL1310110002#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110002#
type: Reaction

metaR NACHEX6ly
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
reversible: false
is described by: ECO:0000000
product: MODEL1310110002#
is: SBO:0000176
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110002#

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaM etfox m
is: SBO:0000247
boundary condition: false
is: CHEBI:17263
initial concentration: 1.0
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: HMDB00145
notes: FORMULA: R CHARGE: 0
name: Electron transfer flavoprotein oxidized

metaR r1429
kinetic law: MODEL1310110002#
fast: false
name: Free diffusion
reactant: MODEL1310110002#
type: Reaction
reversible: true
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaM Rtotal e
is: SBO:0000247
constant: false
has only substance units: false
is: C00255
name: R total
is: HMDB00244
is: CHEBI:3554
type: Species
initial concentration: 1.0
notes: FORMULA: CO2FULLR CHARGE: -1
initial amount: NaN
boundary condition: false

metaR SUCCTD
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinate by diffusion
type: Reaction

metaM nrpphr e
is: SBO:0000247
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
is: HMDB00216
boundary condition: false
is: CHEBI:33569
type: Species
initial amount: NaN
name: Norepinephrine
constant: false
initial concentration: 1.0
has only substance units: false

metaM orn m
type: Species
constant: false
is: C01602
is: HMDB00214
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:46912
name: Ornithine
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: SBO:0000247

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_f9e853c6_ba7d_4d33_8816_3c5b1101ca8d
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2592
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: GALT
is: B2RAT6

metaR ACNACNGALGBSIDEte
type: Reaction
kinetic law: MODEL1310110002#
reversible: true
fast: false
name: acnacngalgbside hs transport
product: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
is: SBO:0000185
reactant: MODEL1310110002#

metaR DM ethamp r
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: Ethanolamine phosphate demand
type: Reaction

metaR OXAtp
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
is: SBO:0000185
reactant: MODEL1310110002#
type: Reaction
reversible: false
name: oxalate transport out of peroxisome
kinetic law: MODEL1310110002#
is described by: ECO:0000000
fast: false
product: MODEL1310110002#

metaR r2066
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110002#
is: SBO:0000185
kinetic law: MODEL1310110002#
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

http://identifiers.org/biomodels.db/MODEL1310110002#_e7e764e1_5a81_499e_a99c_5cb3031f2c11
name: SLC12A6
has only substance units: false
initial concentration: NaN
is: Q9UHW9
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:9990
initial amount: NaN
type: Species

metaR CYSO
name: cysteine oxidase
is version of: http://identifiers.org/ec-code/1.13.11.20
is: SBO:0000176
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (1036.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.20 Confidence Level: 4 AUTHORS: PMID:14514920 NOTES:IT
reversible: false
fast: false
reactant: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000269
modifier: MODEL1310110002#
type: Reaction

metaR ENGASEly
is described by: ECO:0000000
reversible: false
type: Reaction
name: endo-beta-N-acetylglucosaminidase, lysosomal
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
fast: false

metaR G14T13g
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110002#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110002#
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176

metaM glyb m
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
type: Species
is: CHEBI:17750
initial amount: NaN
is: HMDB00043
name: glycine betaine

metaR NDPK2
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
name: nucleoside-diphosphate kinase (ATP:UDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_626e9482_9eb5_414f_8173_b4c1caf06a32
boundary condition: true
has only substance units: false
is: Q9NWW6
initial amount: NaN
initial concentration: NaN
name: NMRK1
type: Species
is: SBO:0000252
is encoded by: hsa:54981
constant: false

metaM CE5788 e
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C41H67N15O9 CHARGE: 2 INCHI: InChI=1/C41H65N15O9/c1-4-22(2)32(42)37(62)51-23(3)33(58)52-27(8-5-15-48-40(43)44)34(59)53-28(9-6-16-49-41(45)46)35(60)54-29(19-25-20-47-21-50-25)38(63)56-17-7-10-31(56)36(61)55-30(39(64)65)18-24-11-13-26(57)14-12-24/h11-14,20-23,27-32,57H,4-10,15-19,42H2,1-3H3,(H,47,50)(H,51,62)(H,52,58)(H,53,59)(H,54,60)(H,55,61)(H,64,65)(H4,43,44,48)(H4,45,46,49)/p+2/t22-,23+,27-,28+,29-,30+,31-,32-/m1/s1 EHMN_ABBREVIATION: CE5788
is: HMDB02710
is: CHEBI:27485
boundary condition: false
initial amount: NaN
name: kinetensin 1-7
initial concentration: 1.0
type: Species

metaM hco3 c
initial concentration: 1.0
initial amount: NaN
is: C00288
name: Bicarbonate
has only substance units: false
is: HMDB00595
type: Species
is: SBO:0000247
is: CHEBI:17544
constant: false
boundary condition: false
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288

metaM cmp g
has only substance units: false
initial amount: NaN
is: HMDB00095
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:60377
boundary condition: false
name: CMP(2-)
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
type: Species

metaM citr L c
has only substance units: false
name: L-citrulline
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: HMDB00904
is: SBO:0000247
is: CHEBI:16349
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false

metaR r0276
type: Reaction
reversible: true
product: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.21
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.2
kinetic law: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
modifier: MODEL1310110002#
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7

metaM ascb L c
is: SBO:0000247
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: CHEBI:38290
is: HMDB00044
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
name: L-ascorbate

metaR LEUGLYPEPT1tc
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucylglycine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

metaM h e
constant: false
is: C00080
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: "
type: Species
is: CHEBI:24636
name: proton
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_ec0fab43_1adc_439c_b8e5_43e09bcd6908
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:56474
name: CTPS2
is: Q9NRF8
constant: false
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_58d79c79_dd1f_4b04_a9fe_7cc9c0d612f3
is encoded by: hsa:55825
type: Species
is: Q9BY49
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
name: PECR

metaR r2065
is: SBO:0000185
kinetic law: MODEL1310110002#
reversible: false
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110002#
fast: false
product: MODEL1310110002#
reactant: MODEL1310110002#

metaR OMPDC
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
modifier: MODEL1310110002#
reversible: false
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.10
product: MODEL1310110002#
name: orotidine-5'-phosphate decarboxylase
is: SBO:0000176
reactant: MODEL1310110002#

metaR EX HC01609 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of UroporphyrinogenI
type: Reaction

metaM thbpt4acam n
has only substance units: false
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
name: 4a-hydroxytetrahydrobiopterin
is: SBO:0000247
initial amount: NaN
is: HMDB02281
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:15374
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_d0bbe5d2_f19f_4016_8947_07a97f36e86c
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: SLC24A4
constant: false
is encoded by: hsa:123041
type: Species

metaM mercppyr c
is: HMDB01368
notes: FORMULA: C3H3O3S CHARGE: -1 INCHI: InChI=1S/C3H4O3S/c4-2(1-7)3(5)6/h7H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00600 EHMN_ABBREVIATION: C00957
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
name: 3-mercaptopyruvate
type: Species
boundary condition: false
is: CHEBI:57678

metaM dgtp n
name: dGTP
initial amount: NaN
is: CHEBI:16497
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: HMDB01440
constant: false
is: C00286
is: SBO:0000247
type: Species
has only substance units: false

metaR r0560
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.2 Confidence Level: 0 AUTHORS: PMID:12855692,PMID:3597357,PMID:6401712,PMID:6874697 NOTES:
fast: false
name: 2-Methylpropanoyl-CoA:oxygen 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.2
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reversible: false

metaR LEUyLAThtc
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Leucine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR EBP1r
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (10682.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.5 Confidence Level: 4 AUTHORS: PMID:10391219 NOTES:involved in lanosterol -> cholesterol pathway NJ
is version of: http://identifiers.org/ec-code/5.3.3.5
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase
is described by: ECO:0000134
reversible: false
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_de989a2b_2f7a_4259_bbc8_6c5a9100fa7d
initial amount: NaN
name: ALG3
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
boundary condition: true
is encoded by: hsa:10195
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_03017039_59c5_4650_9fb1_232509665ee0
constant: false
has only substance units: false
initial concentration: NaN
is encoded by: hsa:83549
name: UCK1
initial amount: NaN
is: SBO:0000252
is: Q5JT09
boundary condition: true
type: Species

metaR ACGBGBSIDEtl
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
reversible: true
name: acgbgbside hs intracellular transport
kinetic law: MODEL1310110002#

metaR EX dhf LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 7,8-Dihydrofolate exchange
type: Reaction

metaM Rtotal c
has only substance units: false
initial amount: NaN
is: HMDB01448
is: SBO:0000247
constant: false
name: R total
initial concentration: 1.0
type: Species
notes: FORMULA: CO2FULLR CHARGE: -1
boundary condition: false
is: CHEBI:16189

metaM nrpphr c
boundary condition: false
is: SBO:0000247
is: HMDB00216
is: CHEBI:33569
type: Species
name: Norepinephrine
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C8H12NO3 CHARGE: 1 INCHI: InChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2 HEPATONET_1.0_ABBREVIATION: HC00426 EHMN_ABBREVIATION: C00547
constant: false

metaR ACNACNGALGBSIDEtg
name: acnacngalgbside hs intracellular transport
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110002#
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110002#

metaR DM Lcystin
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for L-cystine
type: Reaction

metaM Ser Thr g
is: CHEBI:58336
initial amount: NaN
name: protein-linked serine or threonine residue (O-glycosylation site)
is: HMDB00645
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: XH CHARGE: 0

metaM atp n
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00538
is: SBO:0000247
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
name: ATP(3-)
type: Species
boundary condition: false
is: CHEBI:57299
has only substance units: false

metaM atp m
name: ATP(4-)
is: HMDB00538
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: C00002
is: CHEBI:57299
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_9c932e26_6fb3_4c02_8324_ba4e42d9f441
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
constant: false
is: P15954
initial concentration: NaN
is encoded by: hsa:1350
name: COX7C

http://identifiers.org/biomodels.db/MODEL1310110002#_1b89a359_c118_47ca_8c27_17319dc334ee
type: Species
initial amount: NaN
is: SBO:0000252
name: LGSN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51557
constant: false
has only substance units: false
is: Q5TDP6

metaR FAOXC122m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaR PItx
kinetic law: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
type: Reaction
is: SBO:0000185
name: Phosphate transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reversible: true

metaM lnlncg c
is: SBO:0000247
type: Species
constant: false
name: gamma-linolenate
is: HMDB03073
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
has only substance units: false
boundary condition: false
is: CHEBI:32391

http://identifiers.org/biomodels.db/MODEL1310110002#_7ad44831_590f_429e_a5aa_e68cc99e17d4
initial amount: NaN
constant: false
is: O60760
is encoded by: hsa:27306
has only substance units: false
name: HPGDS
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_bad23a8e_0c0c_4d55_ae9c_81307c6e1e2f
constant: false
is: SBO:0000252
is encoded by: hsa:1716
initial concentration: NaN
type: Species
is: E5KSL5
name: DGUOK
initial amount: NaN
has only substance units: false
boundary condition: true

metaR r0917
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110002#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_e504bf2a_45f1_4872_b6ce_0640cba0c8df
is encoded by: hsa:2720
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P16278
constant: false
name: GLB1
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_dfd53f77_19ff_4579_b259_1db0f3eaf43f
is encoded by: hsa:1595
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
is: Q16850
name: CYP51A1
constant: false
has only substance units: false
boundary condition: true

metaM gly e
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: C00037
is: CHEBI:3339
is: SBO:0000247
constant: false
name: Glycine
notes: FORMULA: C2H5NO2 CHARGE: 0
boundary condition: false
is: HMDB00123
type: Species

metaM ksi pre20 g
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:28067
constant: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 20
has only substance units: false
initial amount: NaN
notes: FORMULA: C171H274N12O140S6X CHARGE: -7

metaM ksi pre21 g
is: SBO:0000247
is: CHEBI:58053
constant: false
type: Species
initial concentration: 1.0
is: C00130
initial amount: NaN
has only substance units: false
notes: FORMULA: C177H284N12O145S6X CHARGE: -7
is: HMDB00175
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 21

metaM ksii core2 e
initial amount: NaN
name: keratan sulfate II (core 2-linked)
constant: false
type: Species
is: HMDB00211
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: CHEBI:17268
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_085fd9c1_7ace_4ede_99e8_74fbecfcd841
is: E9PAX2
boundary condition: true
is encoded by: hsa:57818
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
name: G6PC2
has only substance units: false
type: Species

metaR r1428
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110002#
product: MODEL1310110002#
name: Free diffusion
is: SBO:0000185
kinetic law: MODEL1310110002#
fast: false
type: Reaction
reversible: true

metaM dgtp m
constant: false
name: dGTP
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01440
is: C00286
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: CHEBI:16497
boundary condition: false

metaM hco3 e
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288
initial concentration: 1.0
is: C00288
is: HMDB00595
name: Bicarbonate
is: SBO:0000247
type: Species
has only substance units: false
is: CHEBI:17544
constant: false
initial amount: NaN
boundary condition: false

metaR G14T7g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
product: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaR AHCYStr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
name: S-Adenosyl-L-homocysteine intracellular diffusion
reversible: true
kinetic law: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_7cac9aba_ca4d_4018_812d_23fce67c42ad
constant: false
is encoded by: hsa:29922
initial concentration: NaN
is: Q9Y5B8
has only substance units: false
initial amount: NaN
type: Species
name: NME7
boundary condition: true
is: SBO:0000252

metaM h g
name: proton
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
boundary condition: false
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:24636
is: SBO:0000247

metaM udpglcur r
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00935
is: C00167
has only substance units: false
name: UDP-D-glucuronate
is: SBO:0000247
is: CHEBI:58052

http://identifiers.org/biomodels.db/MODEL1310110002#_197d996d_8a4c_4a7c_8eae_4f166a58aab4
is: SBO:0000252
is: F8VQS7
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
name: NDUFA12
constant: false
is encoded by: hsa:55967
initial concentration: NaN

metaR r0915
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
fast: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_47335bad_71f1_4cf4_ac11_3927bb8f814d
name: ALDH1A3
boundary condition: true
type: Species
is: P47895
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:220

metaR SERGLYexR
type: Reaction
reversible: true
is described by: ECO:0000304
kinetic law: MODEL1310110002#
fast: false
product: MODEL1310110002#
is: SBO:0000185
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110002#
name: L-Serine/Glycine reversible exchange

http://identifiers.org/biomodels.db/MODEL1310110002#_cfb1889b_35fb_4419_8f09_0c6eed560e63
is: SBO:0000252
name: UPB1
initial amount: NaN
boundary condition: true
is: B3KNC1
initial concentration: NaN
is encoded by: hsa:51733
type: Species
has only substance units: false
constant: false

metaR FAOXC1811603m
reactant: MODEL1310110002#
name: Beta oxidation fatty acid
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
product: MODEL1310110002#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ

metaR EX itp LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of ITP(3-)
type: Reaction

metaR r2062
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110002#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110002#
reactant: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15

metaR FAEL204
product: MODEL1310110002#
name: fatty-acyl-CoA elongation (n-C20:4CoA)
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
reversible: false
modifier: MODEL1310110002#

metaM hx2coa m
initial concentration: 1.0
has only substance units: false
name: trans-Hex-2-enoyl-CoA
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: HMDB06294
boundary condition: false
constant: false

metaR EX pro L LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Proline exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_bdbe4437_79e3_4b76_bafa_0bf1d1d18ae3
name: CROT
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:54677
is: E7EQF2

metaM ivcoa m
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01021 EHMN_ABBREVIATION: C02939
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01113
is: CHEBI:57345
initial amount: NaN
is: SBO:0000247
name: Isovaleryl-CoA
has only substance units: false
constant: false

metaR CYTK13
fast: false
type: Reaction
reversible: true
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110002#
name: cytidylate kinase (dCMP,dATP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110002#
modifier: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_ed92dae5_dd7e_4ebb_a8e3_d7a4b13597de
type: Species
initial amount: NaN
name: ADSL
is encoded by: hsa:158
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_14c0f54a_00b8_4406_8531_032dc4e08b6f
has only substance units: false
type: Species
is: SBO:0000252
is: P47989
initial amount: NaN
constant: false
is encoded by: hsa:7498
initial concentration: NaN
name: XDH
boundary condition: true

metaR r0051
reversible: true
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.1.3.5
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
modifier: MODEL1310110002#
fast: false
product: MODEL1310110002#
is described by: ECO:0000000

metaR COAtg
is described by: ECO:0000000
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
reversible: true
fast: false
name: CoA transport in Golgi via diffusion
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_b954c6f7_3374_4649_9097_e5983c7cac45
has only substance units: false
is encoded by: hsa:954
boundary condition: true
name: ENTPD2
is: Q5SPY7
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: SBO:0000252

metaR NAGA2ly
fast: false
is: SBO:0000176
kinetic law: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
reversible: false
name: N-acetylgalactosaminidase, alpha-
is version of: http://identifiers.org/ec-code/3.2.1.49

metaM 6thf e
name: hexaglutamyl folate (THF)
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/169691
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C44H51N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/p-1/t21u,22u,23u,24u,25u,43u,44-/m1/s1
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_9e0431b3_31f4_4170_b67a_b4b56ffa0b86
name: ZADH2
initial amount: NaN
is: Q8N4Q0
is encoded by: hsa:284273
is: SBO:0000252
has only substance units: false
constant: false
type: Species
boundary condition: true
initial concentration: NaN

metaR r2061
is: SBO:0000185
kinetic law: MODEL1310110002#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110002#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110002#
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_d5e313c2_bf62_4887_8ce6_c5a1b2258e73
boundary condition: true
name: MAN1A1
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:4121
initial amount: NaN
has only substance units: false
is: P33908
is: SBO:0000252

metaM bilirub r
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
type: Species
boundary condition: false
constant: false
is: CHEBI:57977
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: bilirubin(2-)
is: HMDB00054

metaM HC02149 c
is: CHEBI:28867
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
name: O-Propanoylcarnitine
constant: false
has only substance units: false
type: Species

metaM ksii core2 g
initial concentration: 1.0
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
name: keratan sulfate II (core 2-linked)
is: HMDB00189
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57614
has only substance units: false

metaM pail hs n
name: 1-phosphatidyl-1D-myo-inositol(1-)
initial amount: NaN
has only substance units: false
is: CHEBI:57880
boundary condition: false
is: SBO:0000247
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
initial concentration: 1.0
type: Species
constant: false

metaR CYTK12
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110002#
reversible: true
product: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
is described by: ECO:0000269
reactant: MODEL1310110002#
name: cytidylate kinase (dCMP,dCTP)
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaM kynate c
boundary condition: false
is: HMDB00715
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H6NO3 CHARGE: -1 INCHI: InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)/p-1 EHMN_ABBREVIATION: C01717
is: SBO:0000247
name: kynurenate
initial amount: NaN
type: Species
is: CHEBI:58454
constant: false

metaR r0672
reactant: MODEL1310110002#
product: MODEL1310110002#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.65
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.181 Confidence Level: 0 AUTHORS: PMID:12679481 NOTES:
is described by: ECO:0000000
fast: false
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
name: Cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase Bile acid biosynthesis EC:1.1.1.181
type: Reaction

metaR SQLSr
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
product: MODEL1310110002#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.5.1.21
modifier: MODEL1310110002#
name: Squalene synthase
fast: false
type: Reaction
kinetic law: MODEL1310110002#
is described by: ECO:0000134
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_2da6df54_9984_42cb_9e06_bb8839ed9579
name: IDH2
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3418
is: P48735

metaR RE3003M
name: RE3003
fast: false
is described by: ECO:0000000
reactant: MODEL1310110002#
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/5.3.3.8
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110002#

metaR r2511
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
reversible: true
name: Utilized transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_0b2afb2d_9294_4f9c_80a2_b43ef89892bb
name: B3GNT2
is encoded by: hsa:10678
is: SBO:0000252
constant: false
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR r2399
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1

metaR DAGt
is described by: ECO:0000269
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.1.107 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110002#
name: diacylglycerol transport
type: Reaction
reactant: MODEL1310110002#

metaM h r
boundary condition: false
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
name: proton
is: http://identifiers.org/pubchem.compound/3380
is: CHEBI:24636
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: C00080

http://identifiers.org/biomodels.db/MODEL1310110002#_8bceb1a6_f826_41db_86e9_a139decdedc6
constant: false
is: Q6IBA0
name: NDUFS5
initial amount: NaN
boundary condition: true
is encoded by: hsa:4725
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

metaM citr L e
constant: false
is: SBO:0000247
initial amount: NaN
name: citr_L[e]
has only substance units: false
is: CHEBI:16349
is: HMDB00904
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
initial concentration: 1.0
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_e7d005f3_40b8_4f5c_8fca_9e903bf45f14
boundary condition: true
has only substance units: false
constant: false
type: Species
is: P48764
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6550
name: SLC9A3

metaR r0913
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110002#
is: SBO:0000185
reactant: MODEL1310110002#
reversible: true
product: MODEL1310110002#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110002#_7e9210e4_4dc1_455e_9ecb_7cc35831b7b9
type: Species
initial concentration: NaN
constant: false
name: LDHAL6A
is: SBO:0000252
is: Q6ZMR3
initial amount: NaN
boundary condition: true
is encoded by: hsa:160287
has only substance units: false

metaR DESAT22 1p
reversible: false
fast: false
reactant: MODEL1310110002#
name: fatty acyl-CoA desaturase (n-C22:4CoA -> n-C22:5CoA)
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110002#
is: SBO:0000176

metaR DOLP Uter
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
name: dolichol phosphate flippase (uterus)
type: Reaction

metaR GTHOm
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.8.1.7
name: glutathione oxidoreductase
reversible: false
kinetic law: MODEL1310110002#
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
modifier: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#

metaR DCSPTN1CRNt
kinetic law: MODEL1310110002#
name: transport into the mitochondria (carnitine)
reversible: false
is: SBO:0000185
modifier: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reactant: MODEL1310110002#

metaR r0456
type: Reaction
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
is described by: ECO:0000000
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
modifier: MODEL1310110002#
product: MODEL1310110002#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.21
is version of: http://identifiers.org/ec-code/2.7.1.32

metaR RDH2a
modifier: MODEL1310110002#
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (195814.1) or (112724.1) or (145226.1) or (51109.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12435598,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.105
is version of: http://identifiers.org/ec-code/1.1.1.300
product: MODEL1310110002#
name: retinol dehydrogenase (9-cis,NADPH)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_f7374511_1e43_49e0_95b3_2a860b14a9c1
is encoded by: hsa:2876
is: P07203
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
name: GPX1
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_dfed0c41_a39a_4b7e_944b_973aabac8356
constant: false
initial amount: NaN
boundary condition: true
name: _7359_1_c
initial concentration: NaN
type: Species
is encoded by: hsa:7359
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_d5abe257_5caf_4c7e_9d53_715ce91ccfd5
is encoded by: hsa:3418
boundary condition: true
initial concentration: NaN
name: IDH2
is: SBO:0000252
constant: false
initial amount: NaN
is: P48735
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_7d37eb90_7d4d_4ff8_a699_e5aaad4774ef
name: NDUFB10
initial amount: NaN
is: A8K761
is: SBO:0000252
is encoded by: hsa:4716
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_e07dde5c_a249_4420_b343_37830f1303a7
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is: P11908
initial concentration: NaN
boundary condition: true
name: PRPS2
is encoded by: hsa:5634
type: Species

metaR OXAHCOtex
fast: false
product: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
name: oxalate transport via bicarbonate countertransport
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (1836.1) or (10861.1) or (10861.3) or (10861.2) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is described by: ECO:0000304
kinetic law: MODEL1310110002#

metaR r2108
modifier: MODEL1310110002#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_6259ad37_4fea_401d_9c7c_77122038a49b
type: Species
name: SOD1
is encoded by: hsa:6647
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P00441

http://identifiers.org/biomodels.db/MODEL1310110002#_eeeac001_0c77_455d_a822_cba611798f9c
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P19367
constant: false
name: HK1
is: SBO:0000252
type: Species
is encoded by: hsa:3098

metaR MI14P4P
reactant: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
name: inositol-1,4-bisphosphate 4-phosphatase
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110002#

metaR CYTK11
name: cytidylate kinase (dCMP,dGTP)
product: MODEL1310110002#
type: Reaction
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
modifier: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110002#

metaR r2398
reversible: false
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction

metaR PPA
fast: false
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110002#
is: SBO:0000176
product: MODEL1310110002#
name: inorganic diphosphatase
is version of: http://identifiers.org/ec-code/3.6.1.1
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:

metaM 5aop m
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430
initial amount: NaN
is: SBO:0000247
is: CHEBI:17549
is: HMDB01149
constant: false
name: 5-Amino-4-oxopentanoate
is: C00430
initial concentration: 1.0
type: Species
boundary condition: false

metaR r2510
name: Utilized transport
reactant: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_c99d0be6_6a8a_4681_add2_68c6af604e56
boundary condition: true
initial amount: NaN
is encoded by: hsa:158
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
has only substance units: false
name: ADSL
is: P30566

metaR VALt5m
fast: false
reversible: true
name: Valine reversible mitochondrial transport
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
is: SBO:0000185

metaR EX prostgd2 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin D2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_92889ee0_ff67_4322_b828_e2ba5f5bf00e
name: _AI935189_1_m
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI935189
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252

metaM ksii core4 deg2 l
initial amount: NaN
type: Species
name: keratan sulfate II (core 4-linked), degradation product 2
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
is: HMDB00143
boundary condition: false
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110002#_1ce382aa_e64e_4455_8d1e_e82cb5135e12
name: SLC26A7
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:115111
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaR r0670
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110002#
product: MODEL1310110002#
fast: false
reversible: false
name: (S)-3-Methyl-2-oxopentanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
reactant: MODEL1310110002#
is described by: ECO:0000000

metaM sT antigen g
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C25H40N2O18X CHARGE: -1
initial amount: NaN
name: sialyl-T antigen
boundary condition: false
is: CHEBI:16565
is: SBO:0000247
constant: false

metaM gthox m
is: SBO:0000247
boundary condition: false
type: Species
constant: false
initial amount: NaN
is: CHEBI:58297
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: HMDB03337

metaR r2109
kinetic law: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110002#
product: MODEL1310110002#

metaR CYTK10
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110002#
type: Reaction
reversible: true
name: cytidylate kinase (CMP,dGTP)
product: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110002#

metaM dudp c
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:60471
initial concentration: 1.0
name: dUDP
type: Species
has only substance units: false
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial amount: NaN
is: HMDB01000
is: C01346

metaR EX estrones LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Estrone 3-sulfate exchange
type: Reaction

metaR r0911
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
is: SBO:0000185
name: Facilitated diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11004451,PMID:8898903 NOTES:

metaR DITPtn
name: dITP nuclear transport
reversible: true
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000185
kinetic law: MODEL1310110002#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR S6T11g
reactant: MODEL1310110002#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD

metaR RE1522M
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
name: RE1522
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reversible: true
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
modifier: MODEL1310110002#
is described by: ECO:0000000

metaM glyb c
is: CHEBI:17750
has only substance units: false
boundary condition: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
constant: false
is: HMDB00043
type: Species
is: SBO:0000247
initial concentration: 1.0
name: glycine betaine
initial amount: NaN

metaM orn e
is: HMDB00214
is: CHEBI:0
constant: false
is: C01602
name: Ornithine
notes: FORMULA: C5H13N2O2 CHARGE: 1
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM malcoa c
name: Malonyl-CoA
is: CHEBI:57384
is: HMDB01175
is: SBO:0000247
initial concentration: 1.0
is: C00083
has only substance units: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
boundary condition: false

metaM cs c deg3 l
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 3
type: Species
notes: FORMULA: C31H48NO32S2 CHARGE: -3
initial amount: NaN
has only substance units: false
is: HMDB00127
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:15748
is: SBO:0000247

metaR 2AMADPTm
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877
is described by: ECO:0000269
reversible: true
name: L-2-aminoadipate shuttle (cytosol/mitochondria)
is: SBO:0000185
fast: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction

metaR ALAt2r
product: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
name: L-alanine reversible transport via proton symport
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD
modifier: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000304
reversible: true
fast: false
reactant: MODEL1310110002#

metaM h l
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: "
initial amount: NaN
name: proton
is: C00080
is: CHEBI:24636
is: SBO:0000247
type: Species
constant: false

metaR r1933
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
reversible: false

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR r2106
modifier: MODEL1310110002#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#

metaM atp x
is: C00002
type: Species
is: CHEBI:57299
is: HMDB00538
is: SBO:0000247
name: ATP(4-)
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0

metaR F1PGT
fast: false
reactant: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
reversible: true
product: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
name: fucose-1-phosphate guanylyltransferase
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.7.30
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110002#_029986dd_f266_4a07_acae_58ec68c30b45
is encoded by: hsa:117248
name: GALNTL2
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q8N3T1
has only substance units: false
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_7fc1f730_e3ba_471e_975c_f1892da70a07
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: MYO5B
constant: false
is encoded by: hsa:4645
is: Q9H6Y6
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_2a1b3d05_19aa_481f_91e5_3b8765093472
is: P27144
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: AK4
is encoded by: hsa:205
is: SBO:0000252
boundary condition: true
constant: false

metaR NACHEXA21ly
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase A, lysosomal
product: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reversible: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_e2410578_51aa_4b51_8db4_333d7ff22979
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true
is encoded by: hsa:AA081045
initial concentration: NaN
name: _AA081045_1_e

metaR r1765
is described by: ECO:0000000
reactant: MODEL1310110002#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
modifier: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_736cfe7a_654d_40d6_bd24_b11491cf28c9
type: Species
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
name: ALG2
initial concentration: NaN
is encoded by: hsa:85365

metaR r0055
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
modifier: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/2.4.2.7
is version of: http://identifiers.org/ec-code/2.4.2.8
product: MODEL1310110002#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110002#
reversible: true
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
is described by: ECO:0000000
kinetic law: MODEL1310110002#

metaM ksii core4 l
is: CHEBI:57614
has only substance units: false
is: HMDB00189
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
constant: false
initial amount: NaN
name: keratan sulfate II (core 4-linked)

metaR GLCAASE6ly
is: SBO:0000176
fast: false
reactant: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false
name: beta-glucuronidase, lysosomal
modifier: MODEL1310110002#

metaM core2 g
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15876
name: Core 2
boundary condition: false
type: Species
notes: FORMULA: C22H37N2O15X CHARGE: 0
constant: false
has only substance units: false

metaM h m
constant: false
is: C00080
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR DRPA
reactant: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
name: deoxyribose-phosphate aldolase
fast: false
kinetic law: MODEL1310110002#
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaR r2107
type: Reaction
kinetic law: MODEL1310110002#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
product: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110002#

metaR DGNSKm
type: Reaction
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000269
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.1.113
notes: GENE_ASSOCIATION: (1716.5) or (1716.1) or (1716.4) or (1716.2) or (1716.3) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 4 AUTHORS: PMID:12535661,PMID:8692979 NOTES:
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
name: deoxyguanosine kinase

metaR ACGBGBSIDEtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
is described by: ECO:0000000
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
is: SBO:0000185
name: acgbgbside hs intracellular transport
reactant: MODEL1310110002#
reversible: true

metaR r0308
type: Reaction
kinetic law: MODEL1310110002#
product: MODEL1310110002#
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
is: SBO:0000176
modifier: MODEL1310110002#
fast: false
reversible: false
is described by: ECO:0000000

metaR NS26T2g
reversible: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
is described by: ECO:0000000
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.99.3
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (55808.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.3 Confidence Level: 0 AUTHORS: PMID:10536037 NOTES:NCD
is: SBO:0000176

metaM nadh c
boundary condition: false
is: HMDB01487
name: Nicotinamide adenine dinucleotide - reduced
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3306
is: SBO:0000247
is: CHEBI:57945
constant: false
initial concentration: 1.0
type: Species
is: C00004

metaM cholate e
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
name: Cholate
constant: false
is: CHEBI:29747
is: HMDB00619
initial concentration: 1.0
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695

metaM pchol hs r
name: Phosphatidylcholine
has only substance units: false
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
initial amount: NaN
boundary condition: false
is: CHEBI:16110
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR r0983
kinetic law: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: false
product: MODEL1310110002#
is: SBO:0000185
fast: false
name: solute carrier family 27 (fatty acid transporter), member 5 TCDB:4.C.1.1.5 TCDB:4.C.1.1.8

metaR AG13T18g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (10678.2) or (11041.1) or (10678.1) or (374907.2) or (93010.1) or (374907.1) or (146712.1) or (79369.1) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: false
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176

metaR OCDCAtr
fast: false
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reversible: true
product: MODEL1310110002#
is described by: ECO:0000000
name: fatty acid transport via diffusion

metaM HC00822 l
is: CHEBI:28681
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
name: Chitobiose
initial concentration: 1.0
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674

metaR MECOALm
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.5
is described by: ECO:0000212
reversible: true
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
fast: false
reactant: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD

metaM gm3 hs g
type: Species
initial amount: NaN
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
initial concentration: 1.0
boundary condition: false
is: CHEBI:60065
has only substance units: false
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
is: SBO:0000247
constant: false

metaR DUMPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110002#
is described by: ECO:0000000
reversible: true
product: MODEL1310110002#
name: dUMP nuclear transport
type: Reaction
kinetic law: MODEL1310110002#
fast: false
is: SBO:0000185

metaM ksii core2 l
constant: false
type: Species
is: CHEBI:57614
name: keratan sulfate II (core 2-linked)
is: HMDB00189
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
initial amount: NaN
initial concentration: 1.0

metaM h n
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:24636
name: proton
is: SBO:0000247
constant: false
type: Species

metaR r2104
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaM rbt c
name: D-ribitol
type: Species
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:15963
is: HMDB00508
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
constant: false
boundary condition: false

metaR CYTK8n
is described by: ECO:0000269
kinetic law: MODEL1310110002#
product: MODEL1310110002#
name: cytidylate kinase (CMP,dATP),nuclear
reactant: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
fast: false
reversible: true
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

metaR NDPK8
kinetic law: MODEL1310110002#
reversible: true
product: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
name: Nucleoside-diphosphate kinase (ATP:dADP)
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110002#

metaM glyb e
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-6(2,3)4-5(7)8/h4H2,1-3H3 HEPATONET_1.0_ABBREVIATION: HC00515 EHMN_ABBREVIATION: C00719
is: HMDB00043
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: glycine betaine
is: CHEBI:17750

metaR r1935
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reversible: false
fast: false
modifier: MODEL1310110002#
reactant: MODEL1310110002#
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
is: SBO:0000185

metaR DRIBt
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
name: deoxyribose transport via diffusion
kinetic law: MODEL1310110002#
fast: false
product: MODEL1310110002#
reversible: true

metaR r2318
fast: false
reactant: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110002#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
product: MODEL1310110002#

metaR GFUCS
is: SBO:0000176
is described by: ECO:0000000
name: GDP-L-fucose synthase
is version of: http://identifiers.org/ec-code/1.1.1.271
reactant: MODEL1310110002#
reversible: false
fast: false
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.271 Confidence Level: 0 AUTHORS: NOTES:Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent. IT
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
product: MODEL1310110002#

metaR FAOXC163Gm
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

metaM co2 r
boundary condition: false
is: CHEBI:16526
has only substance units: false
constant: false
initial concentration: 1.0
name: CO2
initial amount: NaN
is: C00011
type: Species
is: SBO:0000247
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967

metaR NDPK7
fast: false
modifier: MODEL1310110002#
reversible: true
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:dCDP)
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_751dd812_cc9c_407c_8ba6_c1229e3dca4b
name: _AA502753_1_m
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:AA502753
boundary condition: true
type: Species
initial amount: NaN

metaR AG13T10g
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.149
reactant: MODEL1310110002#
product: MODEL1310110002#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

http://identifiers.org/biomodels.db/MODEL1310110002#_7e132e26_88bd_40a9_b823_6a107516334c
constant: false
is encoded by: hsa:AI435857
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: _AI435857_1_x
has only substance units: false

metaR LPCOXp
name: L-pipecolate oxidase, peroxisomal
modifier: MODEL1310110002#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.3.1
notes: GENE_ASSOCIATION: (51268.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.3.7 Confidence Level: 4 AUTHORS: PMID:10772957 NOTES:
fast: false
product: MODEL1310110002#
is: SBO:0000176

metaR PAPStg
fast: false
reactant: MODEL1310110002#
name: 3'-Phosphoadenylyl sufate Golgi transport
is: SBO:0000185
reversible: true
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
modifier: MODEL1310110002#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110002#

metaR FAOXC16OHC16r
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(C16-->w-OHC16)er
type: Reaction

metaR OCCOAtx
is described by: ECO:0000000
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
reversible: true
reactant: MODEL1310110002#

metaR r2105
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
reversible: true
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000185

metaM hmgcoa x
constant: false
is: CHEBI:15467
is: SBO:0000247
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
name: Hydroxymethylglutaryl-CoA
is: HMDB01375
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_06ac7a5e_3a38_4d0a_b259_a972adca1adb
has only substance units: false
initial concentration: NaN
is encoded by: hsa:80025
boundary condition: true
type: Species
is: Q6P1K9
name: PANK2
initial amount: NaN
constant: false
is: SBO:0000252

metaR GK1
fast: false
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110002#
is described by: ECO:0000269
name: guanylate kinase (GMP:ATP)
modifier: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.4.8

metaR NDPK9
type: Reaction
name: nucleoside-diphosphate kinase (ATP:IDP)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
product: MODEL1310110002#
reversible: true
fast: false

metaM gly m
is: C00037
constant: false
name: Glycine
is: CHEBI:15428
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
type: Species
is: SBO:0000247
is: HMDB00123
has only substance units: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_4a5657ba_01ab_4c78_bba9_fad3375e2f1e
is: Q4G1C4
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:284273
initial amount: NaN
name: ZADH2

metaR CYSTSERex
notes: GENE_ASSOCIATION: (6519.1 and 11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: NOTES:SAB see PMID 14770310
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#
reversible: false
fast: false
reactant: MODEL1310110002#
is described by: ECO:0000269
name: L-cystine/glycine exchanger (cystine in)
type: Reaction

metaR r0780
product: MODEL1310110002#
is: SBO:0000176
type: Reaction
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
reversible: true
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
fast: false
reactant: MODEL1310110002#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110002#_58f25d6e_2ed6_4016_bc07_62f39403e9b6
initial concentration: NaN
is encoded by: hsa:6569
name: SLC34A1
constant: false
has only substance units: false
is: SBO:0000252
is: Q7Z725
initial amount: NaN
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_e62fe9a1_18da_44b7_ac4b_b93ceb19eff0
constant: false
name: MPST
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4357
has only substance units: false
is: P25325

metaM taur c
initial concentration: 1.0
is: SBO:0000247
is: C00245
is: HMDB00251
boundary condition: false
has only substance units: false
notes: FORMULA: C2H7NO3S CHARGE: 0
constant: false
initial amount: NaN
type: Species
name: Taurine
is: CHEBI:3544

metaR r2319
kinetic law: MODEL1310110002#
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110002#
type: Reaction

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

metaM dcmp c
initial concentration: 1.0
type: Species
name: dCMP
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB01202
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
initial amount: NaN
is: CHEBI:57566
is: C00239

metaR EX adp
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adp exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_3fb1a6c6_2808_4444_89cd_732b26183028
initial amount: NaN
is encoded by: hsa:116369
initial concentration: NaN
has only substance units: false
is: Q96RN1
is: SBO:0000252
constant: false
boundary condition: true
name: SLC26A8
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_83121700_7366_4117_a447_40f78cd22470
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:3948
is: P07864
initial amount: NaN
name: LDHC

metaM ru5p D c
boundary condition: false
is: CHEBI:58121
type: Species
constant: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: HMDB00618
initial concentration: 1.0
name: D-ribulose 5-phosphate(2-)
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR EX cytd LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Cytidine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_0f36cf1d_aff7_4db5_b678_d5c69ebbdaed
is encoded by: hsa:6675
type: Species
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: Q16222
is: SBO:0000252
has only substance units: false
name: UAP1

metaR r1615
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110002#
is described by: ECO:0000000

metaR FRDPtc
is described by: ECO:0000000
product: MODEL1310110002#
is: SBO:0000185
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
kinetic law: MODEL1310110002#
name: lipid, flip-flop intracellular transport
reversible: true
type: Reaction

metaR EX dttp LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTTP(4-)
type: Reaction

metaM ps hs c
name: ps_hs[c]
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:18303
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_87901337_a5bf_4756_93cc_21c530e43642
is: P04066
type: Species
name: FUCA1
initial concentration: NaN
is encoded by: hsa:2517
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true

metaR ORNt3m
fast: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
name: ornithine mitochondrial transport via proton antiport
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
type: Reaction
reversible: true
modifier: MODEL1310110002#
is described by: ECO:0000269

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_aca625e3_9ffb_436b_b013_b0368ed5c2be
name: UMPS
type: Species
is: SBO:0000252
is: A8K5J1
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:7372
initial concentration: NaN

metaM ethamp r
is: HMDB00224
is: SBO:0000247
type: Species
constant: false
is: CHEBI:58190
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
name: O-phosphonatoethanaminium(1-)
initial amount: NaN

metaR r2329
kinetic law: MODEL1310110002#
product: MODEL1310110002#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110002#
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR P450SCC1m
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
is: SBO:0000176
fast: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#
name: cholesterol monooxygenase

metaM 6pgl r
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
initial amount: NaN
boundary condition: false
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
type: Species
is: CHEBI:57955
constant: false
is: HMDB01127
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaR ACACtx
reactant: MODEL1310110002#
is described by: ECO:0000000
name: acetoacetate intracellular transport unknown mechanism
is: SBO:0000185
product: MODEL1310110002#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_ace75b05_c873_42d7_86ea_b108006796e6
constant: false
initial amount: NaN
is: Q16854
type: Species
is: SBO:0000252
is encoded by: hsa:1716
boundary condition: true
has only substance units: false
name: DGUOK
initial concentration: NaN

metaM dump c
is: C00365
boundary condition: false
notes: FORMULA: C9H11N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
name: dUMP
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:246422
has only substance units: false
is: HMDB01409
constant: false

metaM ksi pre28 g
initial amount: NaN
is: HMDB00175
constant: false
has only substance units: false
is: C00130
type: Species
name: keratan sulfate I biosynthesis, precursor 28
boundary condition: false
notes: FORMULA: C213H341N15O176S8X CHARGE: -9
is: CHEBI:58053
initial concentration: 1.0
is: SBO:0000247

metaR r0668
modifier: MODEL1310110002#
type: Reaction
reversible: true
reactant: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
product: MODEL1310110002#
fast: false
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43
is version of: http://identifiers.org/ec-code/2.4.2.19

metaM cspg c l
initial amount: NaN
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: C00318
initial concentration: 1.0
is: CHEBI:16347
boundary condition: false
is: SBO:0000247
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan
type: Species
has only substance units: false
is: HMDB00062
constant: false

metaM ru5p D r
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00188
is: HMDB00618
name: D-ribulose 5-phosphate(2-)
constant: false
has only substance units: false
is: CHEBI:58121

http://identifiers.org/biomodels.db/MODEL1310110002#_faf67639_54c8_43d4_b738_e9379cbe2c82
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:23305
constant: false
name: ACSL6
is: B2RB13

metaR RE3346C
product: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
reversible: true
name: RE3346
type: Reaction
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176

metaM na1 r
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:29101
constant: false
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
boundary condition: false
name: sodium(1+)
initial amount: NaN
initial concentration: 1.0
is: HMDB00588

metaR LCADi D
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.1.36
modifier: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000304
name: lactaldehyde dehydrogenase

metaM 2dr5p c
has only substance units: false
constant: false
boundary condition: false
name: 2-deoxy-D-ribose 5-phosphate(2-)
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
is: CHEBI:57651
initial concentration: 1.0
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB01031

metaR r1616
reactant: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
fast: false
reversible: true
modifier: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_78e30162_64d3_4f43_82f5_c07f3e25a2e1
constant: false
is: Q9Y2C5
is: SBO:0000252
boundary condition: true
name: SLC17A4
is encoded by: hsa:10050
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species

metaR r2328
type: Reaction
reactant: MODEL1310110002#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true

metaM HC02213 e
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28031
has only substance units: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
boundary condition: false
name: prostaglandin-e3

metaM HC01403 m
initial concentration: 1.0
name: (S)-Hydroxydecanoyl-CoA
type: Species
is: CHEBI:28325
has only substance units: false
initial amount: NaN
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_bf87031a_fda2_426e_af1c_7dc99bbc533a
initial concentration: NaN
name: ACADM
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: P11310
is encoded by: hsa:34
constant: false

metaR RE1530C
is described by: ECO:0000000
name: RE1530
reversible: true
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
type: Reaction
is: SBO:0000176
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:

metaR PROSTGE1t
name: prostaglandin transport via bicarbonate countertransport
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
type: Reaction
modifier: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000185

metaM pe hs r
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
type: Species
is: CHEBI:16038
initial amount: NaN
name: phosphatidylethanolamine
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110002#_c01fd50a_cb2a_407d_8038_ea7db26df312
is encoded by: hsa:10935
type: Species
name: PRDX3
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: E9PH29
constant: false
boundary condition: true

metaM atp c
name: ATP(4-)
constant: false
boundary condition: false
is: HMDB00538
type: Species
is: CHEBI:30616
is: C00002
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN

metaM duri e
has only substance units: false
is: C00526
initial amount: NaN
is: HMDB00012
is: SBO:0000247
boundary condition: false
type: Species
constant: false
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: CHEBI:16450
name: Deoxyuridine
initial concentration: 1.0

metaR RIBt
name: ribose transport via diffusion
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000000
product: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false
kinetic law: MODEL1310110002#

metaR DESAT20 1
fast: false
notes: GENE_ASSOCIATION: (3992.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
modifier: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
type: Reaction
name: fatty acyl-CoA desaturase (n-C20:3CoA -> n-C20:4CoA)
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176

metaM rbt e
is: HMDB00508
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5- HEPATONET_1.0_ABBREVIATION: HC00380
name: D-ribitol
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:15963

http://identifiers.org/biomodels.db/MODEL1310110002#_6db61338_b02f_4b5c_8060_da7496a87e08
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:3177
type: Species
initial concentration: NaN
initial amount: NaN
name: SLC29A2
is: Q14542

metaR AHCYStd
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
is: SBO:0000185
product: MODEL1310110002#
reactant: MODEL1310110002#
name: diffusion of S-Adenosyl-L-homocysteine
type: Reaction
fast: false
kinetic law: MODEL1310110002#

metaM ps hs e
constant: false
name: phosphatidylserine
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: CHEBI:18303
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0

metaM CE2420 m
initial amount: NaN
is: HMDB11123
type: Species
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
has only substance units: false
is: CHEBI:28387
boundary condition: false
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
is: SBO:0000247
constant: false
initial concentration: 1.0

metaR r1589
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110002#

metaM ksii core4 pre3 g
is: CHEBI:58053
type: Species
is: HMDB00175
is: SBO:0000247
boundary condition: false
is: C00130
constant: false
notes: FORMULA: C55H89N5O38X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 3
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM thbpt4acam c
name: 4a-hydroxytetrahydrobiopterin
is: HMDB02281
type: Species
initial amount: NaN
is: CHEBI:15374
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
boundary condition: false
constant: false

metaR r1613
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR OCDCEAtr
product: MODEL1310110002#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_1d5e7657_14af_4674_8328_add43ed6796e
initial amount: NaN
type: Species
name: ALPPL2
has only substance units: false
is: P10696
boundary condition: true
constant: false
is encoded by: hsa:251
initial concentration: NaN
is: SBO:0000252

metaR r2506
name: Utilized transport
kinetic law: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110002#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_d5b77790_d155_4f06_81c6_8f710f6379d0
initial amount: NaN
has only substance units: false
is encoded by: hsa:2194
is: P49327
name: FASN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_161135df_19d6_419a_a7ae_5691150e753b
name: _AI378339_1_m
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI378339
type: Species
boundary condition: true

metaM HC02206 e
name: prostaglandin C1(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57399
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR MI145PP
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.36
product: MODEL1310110002#
kinetic law: MODEL1310110002#
name: inositol-1,4,5-trisphosphate 5-phosphatase
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.86
reversible: false
modifier: MODEL1310110002#

metaR r2327
product: MODEL1310110002#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_72a8ccc3_2185_4357_a945_880ab089327d
boundary condition: true
constant: false
name: RDH14
is encoded by: hsa:57665
initial concentration: NaN
is: Q9HBH5
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252

metaM crm hs c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
name: N-acylsphingosine
type: Species
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:52639

metaM L2aadp6sa c
is: HMDB01263
type: Species
initial concentration: 1.0
name: L-allysine
is: SBO:0000247
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
has only substance units: false
is: CHEBI:17917
boundary condition: false
constant: false
initial amount: NaN

metaR r0666
reversible: true
is version of: http://identifiers.org/ec-code/1.2.4.2
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110002#
fast: false
modifier: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_2daca501_a7db_4291_85c5_519ab29940f5
name: GPX4
type: Species
has only substance units: false
is: P36969
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2879
boundary condition: true

metaR DM dsT antigen g
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dsT antigen(g)
type: Reaction

metaM h2o2 e
name: hydrogen peroxide
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: CHEBI:16240

metaM CE2432 m
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,14-15,22-24,28-30,34,45-46H,4-7,10,13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2432
boundary condition: false
name: trans-2-cis,cis-5,8-tetradecatrienoyl-CoA
constant: false
is: CHEBI:57795
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_88af4bb2_a17b_4867_b158_9c66cafa9c4d
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is encoded by: hsa:5092
is: P61457
constant: false
name: PCBD1
is: SBO:0000252

metaR r1614
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
modifier: MODEL1310110002#
reversible: true
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
fast: false

metaM 4ppcys c
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
is: CHEBI:59458
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: C04352
type: Species
initial amount: NaN
is: HMDB01117
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_c44807e4_375b_4395_9005_4a2a79730257
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
name: PKM2
constant: false
is: SBO:0000252
is encoded by: hsa:5315
initial amount: NaN

metaM galgalgalthcrm hs g
has only substance units: false
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: CHEBI:26174

metaR r2507
reactant: MODEL1310110002#
reversible: true
is described by: ECO:0000000
type: Reaction
name: Utilized transport
kinetic law: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
product: MODEL1310110002#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_6e8dd25b_5a27_4afa_bdcd_34a2daf4cd58
is: Q8TE54
has only substance units: false
initial concentration: NaN
type: Species
name: SLC26A7
initial amount: NaN
boundary condition: true
is encoded by: hsa:115111
constant: false
is: SBO:0000252

metaM mercplac c
initial amount: NaN
is: HMDB02127
is: SBO:0000247
has only substance units: false
is: C05823
name: 3-Mercaptolactate
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H5O3S CHARGE: -1 INCHI: InChI=1/C3H6O3S/c4-2(1-7)3(5)6/h2,4,7H,1H2,(H,5,6) EHMN_ABBREVIATION: C05823
is: http://identifiers.org/pubchem.compound/8118
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_7e6d9fb0_dcd8_40e7_8763_0a5679da54c5
initial amount: NaN
is encoded by: hsa:55753
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is: Q9ULD0
name: OGDHL
initial concentration: NaN

metaR r2326
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
product: MODEL1310110002#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_986ff492_be53_4f57_8bc7_75cc22ee8bf0
initial concentration: NaN
is: B3KVI7
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:3712
name: IVD
constant: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_359cb20e_1d63_47db_9ff4_8502146e5bdb
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q9P0Z9
type: Species
is encoded by: hsa:51268
name: PIPOX
constant: false

metaR r2443
type: Reaction
kinetic law: MODEL1310110002#
reversible: false
is described by: ECO:0000000
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
is: SBO:0000185
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110002#

metaM pail hs c
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02009 EHMN_ABBREVIATION: C01194
name: 1-phosphatidyl-1D-myo-inositol(1-)
has only substance units: false
is: CHEBI:57880
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_d7eb4667_03af_4cca_887e_3c3600447784
constant: false
name: ALG1
is: Q9BT22
is encoded by: hsa:56052
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true

metaM nadh r
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
type: Species
is: HMDB01487
is: SBO:0000247
is: CHEBI:57945
boundary condition: false
initial concentration: 1.0
constant: false
name: NADH(2-)
has only substance units: false
initial amount: NaN

metaM orn c
name: Ornithine
is: HMDB00214
is: CHEBI:0
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H13N2O2 CHARGE: 1
is: C01602
type: Species
has only substance units: false
is: SBO:0000247

metaR DOLPMT3 Uer
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.260
type: Reaction
is described by: ECO:0000000
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
modifier: MODEL1310110002#
fast: false
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_927e2484_812e_457c_91d4_3ddf48fd3a41
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is: P30520
is encoded by: hsa:159
boundary condition: true
type: Species
name: ADSS

metaM sphings c
type: Species
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/p+1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00271 EHMN_ABBREVIATION: C00319
name: sphingosine(1+)
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00252
is: CHEBI:57756
initial concentration: 1.0
is: SBO:0000247

metaR r1588
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110002#
fast: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110002#

metaR MALSO3tm
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110002#
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110002#
name: Malate:sulfite antiport, mitochondrial
is described by: ECO:0000269

metaM bilglcur r
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
name: mono(glucosyluronic acid)bilirubin(2-)
has only substance units: false
is: CHEBI:57767
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR DNDPt25m
name: dTDP transport via dCDP antiport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
reversible: false
modifier: MODEL1310110002#
product: MODEL1310110002#
fast: false
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#

metaR EX ksii core2 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 2-linked) exchange
type: Reaction

metaM crn m
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: CHEBI:16347
name: L-Carnitine
type: Species
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
is: C00318
initial concentration: 1.0
is: HMDB00062

metaR r0774
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true
product: MODEL1310110002#
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
type: Reaction
reactant: MODEL1310110002#

metaR r1619
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR EX sfcys LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for sulfocysteine
type: Reaction

metaR FMNALKPle
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is described by: ECO:0000134
reactant: MODEL1310110002#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
name: FMNALKPle

metaR CGLYt3 2
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
reversible: false
fast: false
product: MODEL1310110002#
is: SBO:0000185
name: Cys-Gly transport in via proton symport
is described by: ECO:0000304
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (6565.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12905028 NOTES:SAB

metaM gly x
type: Species
is: HMDB00123
name: glycine
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0 INCHI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
is: CHEBI:15428
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_bc148258_b518_4973_8f13_81fb750d6fca
name: MAN1A2
boundary condition: true
type: Species
initial concentration: NaN
is: O60476
is encoded by: hsa:10905
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252

metaR r1587
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false

metaR EX h2o2 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen peroxide exchange
type: Reaction

metaR ATP2ter
is described by: ECO:0000000
fast: false
product: MODEL1310110002#
name: AMP/ATP transporter, endoplasmic reticulum
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaR r2325
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110002#
type: Reaction
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110002#

metaM Lcystin e
type: Species
is: SBO:0000247
is: HMDB00192
has only substance units: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
initial amount: NaN
name: L-cystine
is: CHEBI:16283
initial concentration: 1.0
constant: false
boundary condition: false

metaM fol e
type: Species
constant: false
is: SBO:0000247
boundary condition: false
name: Folate
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00121

http://identifiers.org/biomodels.db/MODEL1310110002#_82cba54e_d2bf_44b8_945b_45dbb54cc392
is encoded by: hsa:5293
initial concentration: NaN
is encoded by: hsa:8503
has part: A7E2E0
name: PIK3CD:PIK3R3
constant: false
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000297
has part: Q92569

metaR MI145PK
modifier: MODEL1310110002#
is: SBO:0000176
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.127
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
name: inositol-1,4,5-trisphosphate 3-kinase
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD
reversible: false

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

metaM his L e
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: CHEBI:15971
initial concentration: 1.0
constant: false
is: HMDB00177
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: SBO:0000247
name: L-histidine

metaM xol7ah2 c
type: Species
name: 5beta-cholestane-3alpha,7alpha-diol
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB06893
is: CHEBI:28047
has only substance units: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
initial concentration: 1.0

metaR RDH1a
product: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.300
kinetic law: MODEL1310110002#
reversible: true
name: retinol dehydrogenase (all-trans,NADPH)
is version of: http://identifiers.org/ec-code/1.1.1.105
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (157506.1) or (112724.1) or (145226.1) or (51109.1) or (195814.1) or (57665.1) or (50700.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:12407145,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT

http://identifiers.org/biomodels.db/MODEL1310110002#_23347343_08e9_4405_964c_58e8e125cc93
is: SBO:0000252
type: Species
is: Q9BYG0
name: B3GNT5
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:84002

metaR ACALDtm
fast: false
reversible: true
name: acetaldehyde mitochondrial diffusion
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:9028626 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110002#
type: Reaction

metaM gua c
name: Guanine
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: HMDB00132
type: Species
initial concentration: 1.0
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
has only substance units: false
is: CHEBI:16235
constant: false
is: C00242

http://identifiers.org/biomodels.db/MODEL1310110002#_bdc830bc_b163_4981_81e9_5695ff3d8d74
name: GALT
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:2592
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
is: B2RAT6

metaM lnlncg r
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:32391
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
initial concentration: 1.0
is: SBO:0000247
is: HMDB03073
name: gamma-linolenate
type: Species

metaM xol25oh r
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01146
is: HMDB06247
type: Species
is: CHEBI:42977
is: SBO:0000247
name: 25-hydroxycholesterol
has only substance units: false

metaM tchola c
is: SBO:0000247
initial concentration: 1.0
name: taurocholic acid
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
constant: false
is: CHEBI:36257
is: HMDB00036
initial amount: NaN

metaR r1586
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX 5thf LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange
type: Reaction

metaR NDPK1n
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110002#
fast: false
modifier: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000134
kinetic law: MODEL1310110002#

metaR DOLPMT1 Uer
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110002#
modifier: MODEL1310110002#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.258
reactant: MODEL1310110002#
fast: false
type: Reaction
kinetic law: MODEL1310110002#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is: SBO:0000176

metaR r2397
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
product: MODEL1310110002#
reversible: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
fast: false

metaR r2324
is: SBO:0000185
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reversible: true
product: MODEL1310110002#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reactant: MODEL1310110002#

metaM dd2coa x
initial amount: NaN
name: trans-Dodec-2-enoyl-CoA
is: CHEBI:57330
initial concentration: 1.0
type: Species
is: HMDB03712
constant: false
boundary condition: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_001a5c24_5ee8_4376_8973_907a3927e4bd
constant: false
is encoded by: hsa:249
has only substance units: false
name: ALPL
boundary condition: true
type: Species
is: SBO:0000252
is: B7Z4Y6
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_46b0097c_44f0_4301_a9ac_9b06782fed56
is: Q16795
initial concentration: NaN
name: NDUFA9
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:4704
has only substance units: false
boundary condition: true

metaM nadh m
initial amount: NaN
has only substance units: false
is: CHEBI:57945
name: Nicotinamide adenine dinucleotide - reduced
constant: false
initial concentration: 1.0
boundary condition: false
is: C00004
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/3306
is: HMDB01487

metaR MAL Lte
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
name: Transport of L-malate
reactant: MODEL1310110002#
is described by: ECO:0000134
type: Reaction
fast: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#

metaR FUT18g
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
fast: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110002#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.69
reversible: false
modifier: MODEL1310110002#
name: Galactoside 2-alpha-L-fucosyltransferase 1
product: MODEL1310110002#
reactant: MODEL1310110002#

metaR CYTK14
is described by: ECO:0000269
modifier: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110002#
name: cytidylate kinase (dCMP,UTP)
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_881146ab_b1ba_447c_98d9_fb080378b65f
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4712
constant: false
is: Q5VYT2
name: NDUFB6
initial amount: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_ea00a655_15ba_486b_b8ea_fc37d516af34
is encoded by: hsa:1384
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: CRAT
boundary condition: true

metaR r1617
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110002#
reversible: true
is: SBO:0000185
reactant: MODEL1310110002#
product: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM dcyt e
constant: false
name: Deoxycytidine
boundary condition: false
initial concentration: 1.0
is: C00881
is: SBO:0000247
type: Species
is: HMDB00014
initial amount: NaN
has only substance units: false
is: CHEBI:15698
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881

metaR r1585
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110002#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110002#_ceeb7c5d_5c4e_4daa_9df6_4288e0ba4fac
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: _AA081045_1_c
type: Species
has only substance units: false
is encoded by: hsa:AA081045

metaM Lcystin c
is: CHEBI:16283
constant: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB00192
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
name: L-cystine
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR r2323
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110002#

metaR NH4t3r
modifier: MODEL1310110002#
name: ammonia transport via proton antiport
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (57127.1) or (6005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:11024028,PMID:12920597,PMID:1417776,PMID:14966114,PMID:15284342,PMID:8595899 NOTES:
product: MODEL1310110002#
reversible: true
is described by: ECO:0000269
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110002#

metaM fol c
name: Folate
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: HMDB00121
is: SBO:0000247

metaM CE5586 c
notes: FORMULA: C7H20N3 CHARGE: 3 INCHI: InChI=1S/C7H17N3/c8-4-1-2-6-10-7-3-5-9/h6H,1-5,7-9H2/p+3/b10-6+ EHMN_ABBREVIATION: CE5586
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:58732
type: Species
is: SBO:0000247
name: N-[(E)-4-ammoniobutylidene]propane-1,3-diaminium
initial concentration: 1.0

metaR NDPK1m
modifier: MODEL1310110002#
is described by: ECO:0000254
reversible: true
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#

metaR CDSm
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.7.41
reversible: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
name: phosphatidate cytidylyltransferase
product: MODEL1310110002#
fast: false
is: SBO:0000176
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (8760.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.41 Confidence Level: 4 AUTHORS: NOTES:inner mitochondrial membrane NJ

metaR 13DAMPPOX
reversible: false
is: SBO:0000176
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.21
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.4.3.6 Confidence Level: 1 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110002#
is described by: ECO:0000212
reactant: MODEL1310110002#
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_metaR_EX_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIA glycolipid exchange
type: Reaction

metaR r0661
fast: false
product: MODEL1310110002#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
type: Reaction

metaR PI34P5K
type: Reaction
notes: GENE_ASSOCIATION: (8394.1) or (23396.1) or (8395.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929,PMID:1850246,PMID:1851250,PMID:2174884,PMID:8042983 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110002#
name: phosphatidylinositol 3,4-bisphosphate 5-kinase
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.68
reactant: MODEL1310110002#
reversible: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#

metaM ksi pre22 g
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 22
is: CHEBI:58053
notes: FORMULA: C185H297N13O150S6X CHARGE: -7
constant: false
initial concentration: 1.0
boundary condition: false
is: C00130
is: HMDB00175
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_80affb74_2f03_4e41_8870_3ca42bd50493
is: Q9UN76
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:11254
name: SLC6A14
type: Species
initial amount: NaN
constant: false

metaM his L c
is: CHEBI:15971
name: L-histidine
constant: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: HMDB00177
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species

metaR r1618
type: Reaction
is: SBO:0000185
reactant: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000

metaM CE2435 m
is: SBO:0000247
constant: false
is: CHEBI:57795
initial concentration: 1.0
name: trans,cis-deca-2,4-dienoyl-CoA
boundary condition: false
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H50N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-11,18-20,24-26,30,41-42H,4-7,12-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-,11-10+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2435
initial amount: NaN
type: Species

metaM gua e
name: guanine
constant: false
is: CHEBI:16235
initial amount: NaN
is: HMDB00132
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
is: SBO:0000247
type: Species
boundary condition: false

metaM duri c
type: Species
has only substance units: false
boundary condition: false
name: Deoxyuridine
initial amount: NaN
is: CHEBI:16450
initial concentration: 1.0
is: HMDB00012
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
is: SBO:0000247
is: C00526
constant: false

metaR KAS8
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
reactant: MODEL1310110002#
is described by: ECO:0000269
reversible: false
type: Reaction
modifier: MODEL1310110002#
is: SBO:0000176
fast: false
product: MODEL1310110002#
name: b-ketoacyl synthetase (palmitate, n-C16:0)

metaM thymd c
constant: false
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
name: Thymidine
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00273
is: SBO:0000247
is: C00214
boundary condition: false
is: CHEBI:17748
initial concentration: 1.0

metaR r1584
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110002#
is described by: ECO:0000000
fast: false
product: MODEL1310110002#
is: SBO:0000185

metaR r0464
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
reversible: true
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
is: SBO:0000176
reactant: MODEL1310110002#

metaM arachdcrn m
initial amount: NaN
has only substance units: false
is: HMDB01322
is: SBO:0000247
is: CHEBI:57387
initial concentration: 1.0
type: Species
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
boundary condition: false
constant: false

metaR EX lcts LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Lactose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_f290d10e_531a_44cb_ae11_71268e76234e
initial amount: NaN
is encoded by: hsa:4329
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ALDH6A1
type: Species
is: Q02252
has only substance units: false

metaM tchola e
type: Species
initial concentration: 1.0
notes: FORMULA: C26H45NO7S CHARGE: 0
name: taurocholic acid
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00036
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_cfc84eab_0946_4955_ba4c_445cc34607fd
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
name: PRDX2
initial concentration: NaN
is encoded by: hsa:7001
has only substance units: false
boundary condition: true

metaR r2322
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110002#
type: Reaction
is described by: ECO:0000000

metaR ALAGLYexR
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
name: L-alanine/glycine reversible exchange
is described by: ECO:0000304

metaM 6dhf e
initial amount: NaN
constant: false
notes: FORMULA: C44H49N12O21 CHARGE: -7 INCHI: InChI=1/C44H54N12O21/c45-21(36(66)67)5-10-26(57)43(15-30(61)62,27(58)11-6-22(46)37(68)69)44(28(59)12-7-23(47)38(70)71,41(76)77-31(63)14-9-25(49)40(74)75)56(29(60)13-8-24(48)39(72)73)35(65)18-1-3-19(4-2-18)51-16-20-17-52-33-32(53-20)34(64)55-42(50)54-33/h1-4,17,21-25,51H,5-16,45-49H2,(H,61,62)(H,66,67)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H3,50,52,54,55,64)/t21-,22-,23-,24-,25-,44+/m0/s1
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: hexaglutamyl folate (DHF)
is: HMDB06563
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_5ea8bc57_0d2b_4438_b6e5_eac15fe13645
initial amount: NaN
is: SBO:0000252
name: CHKB
type: Species
has only substance units: false
boundary condition: true
is: A0PJM6
constant: false
initial concentration: NaN
is encoded by: hsa:1120

metaM HC02213 c
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:28031
name: prostaglandin-e3
type: Species
initial concentration: 1.0
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439

metaR FAOXC16DCr
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16DC)er
type: Reaction

metaR r2321
product: MODEL1310110002#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110002#
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110002#

metaM ser D c
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:16523
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
has only substance units: false
is: HMDB03406
name: D-serine

metaR ARACHCRNt
type: Reaction
is: SBO:0000185
name: transport into the mitochondria (carnitine)
fast: false
modifier: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110002#
reversible: false

metaR EX ctp LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CTP(4-)
type: Reaction

metaR r1583
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110002#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR ABUTt2r
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
type: Reaction
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110002#
reversible: true
modifier: MODEL1310110002#
product: MODEL1310110002#
fast: false
name: 4-aminobutyrate reversible transport in via proton symport

http://identifiers.org/biomodels.db/MODEL1310110002#_89e24c5c_6b75_4f22_a109_c5b84c18ca99
is encoded by: hsa:116369
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
name: SLC26A8

http://identifiers.org/biomodels.db/MODEL1310110002#_2ee3b84d_9ae1_4e65_a691_7afaad2bb4ad
is: A8K3L7
has only substance units: false
boundary condition: true
initial concentration: NaN
name: CDIPT
constant: false
type: Species
is encoded by: hsa:10423
initial amount: NaN
is: SBO:0000252

metaM dttp c
type: Species
is: C00459
boundary condition: false
constant: false
is: CHEBI:37568
name: dTTP
is: HMDB01342
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: SBO:0000247
has only substance units: false

metaM duri m
is: SBO:0000247
is: HMDB00012
initial amount: NaN
has only substance units: false
name: 2'-deoxyuridine
is: CHEBI:16450
initial concentration: 1.0
notes: FORMULA: C9H12N2O5 CHARGE: 0 INCHI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
boundary condition: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_3b11ba15_74ae_46a7_9ea9_24019d3a216e
initial amount: NaN
has only substance units: false
boundary condition: true
name: B3GALNT1
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8706
constant: false
is: Q8TDY1

metaM HC01409 m
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:27540
is: SBO:0000247
initial concentration: 1.0
name: Hexanoyl-CoA
notes: FORMULA: C27H42N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h14-16,20-22,26,37-38H,4-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05270
initial amount: NaN
type: Species

metaR EX HC02202 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin A1(1-) exchange
type: Reaction

metaM 4nph e
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: HMDB01232
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
name: 4-nitrophenolate
is: CHEBI:57917
constant: false

metaR r0779
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
modifier: MODEL1310110002#
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: false

metaR r2320
kinetic law: MODEL1310110002#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reactant: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaM glyc S e
is: HMDB06372
name: (S)-Glycerate
notes: FORMULA: C3H5O4 CHARGE: 0
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
is: CHEBI:33871

metaR RE0944E
name: RE0944
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.17
is: SBO:0000176
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
reversible: true
modifier: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_4ae6df40_e2d7_4836_b54e_0fb66ad7a7d1
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:AL050025
name: _AL050025_1_c
is: SBO:0000252
type: Species
has only substance units: false

metaR CSCPASEly
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reversible: false
name: chondroitin sulfate C proteoglycan protease, lysosome (endosome)
product: MODEL1310110002#
kinetic law: MODEL1310110002#

metaM cmp c
initial amount: NaN
is: CHEBI:60377
is: SBO:0000247
name: CMP
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
constant: false
boundary condition: false
is: HMDB00095
type: Species
has only substance units: false
is: C00055

metaM co2 c
initial amount: NaN
notes: FORMULA: CO2 CHARGE: 0
is: SBO:0000247
name: CO2
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB01967
type: Species
is: CHEBI:3313
has only substance units: false
is: C00011

http://identifiers.org/biomodels.db/MODEL1310110002#_f7204fba_917b_4689_9b31_982ddd57f0ec
has only substance units: false
is: SBO:0000252
type: Species
is: P43034
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:5048
initial concentration: NaN
name: PAFAH1B1

metaM lnlncg e
boundary condition: false
name: gamma-linolenate
is: SBO:0000247
is: CHEBI:32391
has only substance units: false
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12-
initial amount: NaN
initial concentration: 1.0
is: HMDB03073
type: Species

metaM nadh x
is: HMDB01487
is: C00004
is: CHEBI:57945
boundary condition: false
is: SBO:0000247
name: Nicotinamide adenine dinucleotide - reduced
constant: false
type: Species
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3306
initial amount: NaN
has only substance units: false

metaM ksi pre5 g
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C101H164N7O75SX CHARGE: -2
has only substance units: false
is: CHEBI:28067
boundary condition: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 5

http://identifiers.org/biomodels.db/MODEL1310110002#_b148e941_b299_4950_94c5_99fb6350c2e2
type: Species
is: SBO:0000252
is: O43488
has only substance units: false
constant: false
name: AKR7A2
boundary condition: true
is encoded by: hsa:8574
initial amount: NaN
initial concentration: NaN

metaM dolp U r
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
boundary condition: false
is: SBO:0000247
constant: false
name: dolichyl phosphate(2-)
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0

metaR EX oxa LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Oxalate exchange
type: Reaction

metaM CE2417 m
initial amount: NaN
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-24,28-30,34,43,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2417
constant: false
has only substance units: false
is: CHEBI:28387
type: Species
name: 3(S)-hydroxy-5Z,8Z-tetradecadienoyl-CoA
initial concentration: 1.0
is: HMDB11123
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_be305040_9a9c_4feb_ad6e_a83154b720d3
has only substance units: false
is: Q9Y4C5
name: CHST2
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:9435

metaM ocdcea c
constant: false
notes: FORMULA: C18H33O2 CHARGE: -1
initial concentration: 1.0
is: HMDB00207
name: octadecenoate (n-C18:1)
is: CHEBI:0
is: SBO:0000247
type: Species
initial amount: NaN
is: C00712
boundary condition: false
has only substance units: false

metaR PSDm hs
modifier: MODEL1310110002#
reversible: false
name: Phosphatidylserine decarboxylase
is version of: http://identifiers.org/ec-code/4.1.1.65
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
type: Reaction
is: SBO:0000176
product: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
reactant: MODEL1310110002#

metaM udpglcur c
is: HMDB00935
is: C00167
has only substance units: false
initial amount: NaN
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:58052
name: UDP-D-glucuronate
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_29f22e18_ae09_46fb_8436_e28a6bbfc339
is: Q8N4A0
name: GALNT4
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8693
constant: false
is: SBO:0000252
type: Species
has only substance units: false

metaR MI13PP
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
name: inositol-1,3-bisphosphate 3-phosphatase
reactant: MODEL1310110002#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110002#
type: Reaction
fast: false

metaM bilirub c
constant: false
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57977
initial concentration: 1.0
name: bilirubin(2-)
is: HMDB00054
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
boundary condition: false

metaM ser D e
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
name: D-serine
is: CHEBI:16523
initial concentration: 1.0
boundary condition: false
is: HMDB03406
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
has only substance units: false

metaR r0885
reversible: true
reactant: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
is: SBO:0000185
modifier: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.38

metaM arachdcrn x
is: http://identifiers.org/pubchem.compound/5462164
name: C20:4 carnitine
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB01064
is: SBO:0000247
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236

http://identifiers.org/biomodels.db/MODEL1310110002#_92f60f98_aaca_43e5_a9bf_7e67798338df
type: Species
constant: false
is: SBO:0000252
boundary condition: true
is: P00374
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: DHFR
is encoded by: hsa:1719

metaR DOLGLCP Uter
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110002#
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_e1c6bb6e_448d_4d73_89aa_90ef947b624d
initial concentration: NaN
is encoded by: hsa:4694
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: NDUFA1
boundary condition: true
is: Q6IBB5
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_b717444b_240e_4fd8_86b9_8c348b03c74e
is: SBO:0000252
name: HIBCH
constant: false
initial amount: NaN
is encoded by: hsa:26275
is: Q6NVY1
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true

metaR r1581
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110002#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110002#
is described by: ECO:0000000

metaR Ser Thrtg
name: Ser/Thr transport (from golgi to lysosome)
is described by: ECO:0000269
product: MODEL1310110002#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#

metaM h c
notes: FORMULA: H CHARGE: 1 INCHI: "
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
has only substance units: false
is: CHEBI:24636
name: proton
constant: false
boundary condition: false
initial concentration: 1.0
is: C00080

metaM cmp e
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
constant: false
name: CMP(2-)
type: Species
boundary condition: false
is: CHEBI:60377
is: HMDB00095

metaM co2 e
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16526
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
name: CO2
is: C00011
is: HMDB01967
initial concentration: 1.0
constant: false
type: Species
boundary condition: false

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_bc8163fb_0c23_47ea_be13_3b53951c33fe
constant: false
is encoded by: hsa:8803
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000297
name: SUCLG1:SUCLA2
initial concentration: NaN
has part: E5KS60
initial amount: NaN

metaR EX cspg d LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate D (GlcNAc6S-GlcA2S) proteoglycan exchange
type: Reaction

metaR r0553
type: Reaction
fast: false
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
kinetic law: MODEL1310110002#
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110002#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_a2ab3613_44f2_4eb2_afe5_6db465505e8a
is encoded by: hsa:6583
is: SBO:0000252
is: Q9H015
initial concentration: NaN
initial amount: NaN
type: Species
name: SLC22A4
constant: false
boundary condition: true
has only substance units: false

metaR S2TASE4ly
is: SBO:0000176
type: Reaction
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.18 Confidence Level: 4 AUTHORS: PMID:2497731,PMID:4019466,PMID:8993162 NOTES:NCD
reversible: false
reactant: MODEL1310110002#
name: glucuronate-2-sulfatase, lysosomal
kinetic law: MODEL1310110002#
is described by: ECO:0000000

metaR HACD9m
is described by: ECO:0000134
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (3028.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.35 Confidence Level: 4 AUTHORS: PMID:12872843 NOTES:MM. inborn deficiency enzyme causes accumulation of substrate 3-hydroxy-2-methylbutyric acid
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
product: MODEL1310110002#
modifier: MODEL1310110002#

metaM glyc S c
is: CHEBI:33871
name: (S)-Glycerate
notes: FORMULA: C3H5O4 CHARGE: 0
boundary condition: false
is: HMDB06372
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR r1580
is: SBO:0000185
kinetic law: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110002#
reactant: MODEL1310110002#

metaR TSTSTERONEt
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
is: SBO:0000185
name: Testosterone transport
is described by: ECO:0000269

metaM crn c
is: C00318
is: CHEBI:16347
is: HMDB00062
name: L-Carnitine
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false
type: Species

metaR OCCOAtm
is described by: ECO:0000000
type: Reaction
name: Octanoyl-CoA transport, diffusion
reactant: MODEL1310110002#
reversible: false
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
kinetic law: MODEL1310110002#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_029f054b_9941_4758_ad0d_fcad1de74ad1
initial amount: NaN
name: MYO5B
constant: false
is encoded by: hsa:4645
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q9H6Y6

http://identifiers.org/biomodels.db/MODEL1310110002#_64ca0395_627d_4249_b62e_8480836078f2
initial amount: NaN
is: Q8TE04
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:53354
has only substance units: false
name: PANK1

metaR G14T21g
reversible: false
type: Reaction
reactant: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
modifier: MODEL1310110002#
is: SBO:0000176
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.22

http://identifiers.org/biomodels.db/MODEL1310110002#_0a227868_7d48_4f89_9b9b_193493939f7d
is encoded by: hsa:125
initial amount: NaN
constant: false
initial concentration: NaN
name: ADH1B
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
is: P00325

http://identifiers.org/biomodels.db/MODEL1310110002#_ffdf0b0e_782b_482f_a276_209539eee003
is: SBO:0000252
is encoded by: hsa:587
initial amount: NaN
is: O15382
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
name: BCAT2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_2649005b_009b_45c1_8a63_46dbaf75f673
name: ND6
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:4541
boundary condition: true
is: SBO:0000252
is: Q7GXZ1

http://identifiers.org/biomodels.db/MODEL1310110002#_9c469ee8_c480_4dcb_8ec2_9ebd38d876ab
is: P30038
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: ALDH4A1
is encoded by: hsa:8659
type: Species
initial concentration: NaN

metaR r1833
kinetic law: MODEL1310110002#
name: Y+LAT2 Utilized transport
type: Reaction
is: SBO:0000185
modifier: MODEL1310110002#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_70d0820e_08a1_44e5_9599_182d9038e342
initial concentration: NaN
name: _AA788780_1_c
is encoded by: hsa:AA788780
constant: false
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaR r0552
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
fast: false
is version of: http://identifiers.org/ec-code/1.3.5.1
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaM 3aib D m
has only substance units: false
is: C03265
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB02299
name: D-3-Amino-isobutanoate
constant: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
initial concentration: 1.0

metaM ocdcea e
is: HMDB00207
has only substance units: false
notes: FORMULA: C18H33O2 CHARGE: -1
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:0
name: octadecenoate (n-C18:1)
type: Species
initial amount: NaN
is: C00712
constant: false
boundary condition: false

metaR RE1530M
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (7084.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.21
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110002#
name: RE1530
type: Reaction
modifier: MODEL1310110002#
fast: false

metaR SPHS1Ptr
is: SBO:0000185
product: MODEL1310110002#
is described by: ECO:0000000
reversible: true
type: Reaction
name: sphingosine-1-phosphate transport
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:15052333,PMID:15585321 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414 or PMID: 15585321). NJ
fast: false

metaM phe L c
has only substance units: false
initial concentration: 1.0
name: L-phenylalanine
is: HMDB00159
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
is: CHEBI:17295
boundary condition: false
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079

metaR r1434
is described by: ECO:0000000
name: Transport reaction
reactant: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110002#
is: SBO:0000185
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_1a4b0e3d_d8ad_4091_8011_4a35a845bab8
is: O14561
is encoded by: hsa:4706
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: NDUFAB1

metaR EX 2hb LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 2-Hydroxybutyrate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_cefad85d_b1a6_42a7_aa68_2be2fbfc920c
is encoded by: hsa:1666
initial amount: NaN
constant: false
is: Q16698
is: SBO:0000252
name: DECR1
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false

metaM dd2coa m
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
name: trans-dodec-2-enoyl-CoA(4-)
initial amount: NaN
is: HMDB03712
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:57330
initial concentration: 1.0
boundary condition: false
constant: false

metaM bilirub e
type: Species
initial amount: NaN
constant: false
is: HMDB00054
name: bilirubin(2-)
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:57977
notes: FORMULA: C33H34N4O6 CHARGE: -2 INCHI: InChI=1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/p-2/b26-13-,27-14- HEPATONET_1.0_ABBREVIATION: HC00385 EHMN_ABBREVIATION: C00486
has only substance units: false

metaR r0559
reactant: MODEL1310110002#
product: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_2acc1525_6b41_4caa_87eb_e1e2188b604f
name: RRM2B
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q7LG56
is encoded by: hsa:50484
constant: false
has only substance units: false

metaM h2o2 c
type: Species
is: C00027
is: HMDB03125
initial amount: NaN
has only substance units: false
constant: false
is: CHEBI:16240
boundary condition: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
is: SBO:0000247
name: Hydrogen peroxide

metaM his L m
initial concentration: 1.0
name: L-histidine
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
is: CHEBI:15971
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00177
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_fdc8a576_b84f_4b7b_8611_cc4336db8db0
has only substance units: false
constant: false
boundary condition: true
is: E5KSL6
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:1716
initial amount: NaN
type: Species
name: DGUOK

metaM datp n
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: CHEBI:61404
has only substance units: false
constant: false
boundary condition: false
is: HMDB01532
is: C00131
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: dATP

metaR MALTe
product: MODEL1310110002#
name: alpha-glucosidase, extracellular
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.20
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110002#_d2dc9bea_498a_4659_96a2_00416f456c15
is encoded by: hsa:5831
initial concentration: NaN
initial amount: NaN
name: PYCR1
is: A6NFM2
type: Species
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaM HC02206 c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:57399
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-14,17-18,21H,2-11,15H2,1H3,(H,23,24)/p-1/b14-12+/t17-,18+/m0/s1 EHMN_ABBREVIATION: C04686
boundary condition: false
constant: false
name: prostaglandin C1(1-)
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_9dc2d8c8_3b4e_4d98_923f_e303dbb43337
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
is: Q6FHI7
name: CA4
has only substance units: false
initial concentration: NaN
is encoded by: hsa:762
type: Species

metaM cs e l
is: C00318
initial concentration: 1.0
type: Species
is: HMDB00062
is: SBO:0000247
has only substance units: false
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
boundary condition: false
constant: false
is: CHEBI:16347
initial amount: NaN

metaR r2508
name: Utilized transport
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110002#

metaR FUT911g
is described by: ECO:0000269
product: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
fast: false
kinetic law: MODEL1310110002#
name: Alpha-(1,3)-fucosyltransferase
type: Reaction
reversible: false
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.152
is: SBO:0000176

metaM met L c
constant: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
name: L-methionine
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:16643
is: SBO:0000247
has only substance units: false
is: HMDB00696

metaR EX ak2lgchol hs LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-lysoglycerol 3-phosphocholine exchange
type: Reaction

metaR BAAT4x
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 2 AUTHORS: NOTES:fourth version analog added in similarity to BAAT1x, BAAT2x NJ
type: Reaction
product: MODEL1310110002#
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.65
name: bile acid Coenzyme A: amino acid N-acyltransferase
is described by: ECO:0000304
reactant: MODEL1310110002#
fast: false
is: SBO:0000176
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#

metaM crm hs r
has only substance units: false
is: CHEBI:52639
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
is: SBO:0000247
boundary condition: false
name: N-acylsphingosine
constant: false
type: Species

metaR MTHFD2m
product: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
is described by: ECO:0000254
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.5.4.9
fast: false
reversible: true
reactant: MODEL1310110002#
modifier: MODEL1310110002#

metaR r1611
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
product: MODEL1310110002#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR r0122
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:1009117,PMID:7154942 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: false
name: GTP:pyruvate O2-phosphotransferase Purine metabolism EC:2.7.1.40

metaR r1433
product: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
fast: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#

metaR BILDGLCURt
product: MODEL1310110002#
is: SBO:0000185
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000269
type: Reaction
name: bilirubin beta-diglucuronide transport via bicarbonate countertransport
fast: false
reversible: true
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
modifier: MODEL1310110002#

metaR r0558
modifier: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
product: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
is: SBO:0000176
fast: false
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.5.1.3

metaM pchol hs c
is: HMDB00156
initial concentration: 1.0
notes: FORMULA: CHARGE: 0
constant: false
name: pchol_hs[c]
type: Species
is: CHEBI:15589
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM crn e
name: L-Carnitine
type: Species
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:16347
is: C00318
is: SBO:0000247
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: HMDB00062

http://identifiers.org/biomodels.db/MODEL1310110002#_250d7815_4dfe_4f03_9af4_3a609a991ab5
constant: false
name: MTHFD2
is encoded by: hsa:10797
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P13995
has only substance units: false
type: Species
is: SBO:0000252

metaM ala D e
has only substance units: false
is: HMDB01310
initial amount: NaN
name: D-alanine
is: CHEBI:15570
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
boundary condition: false

metaM datp m
has only substance units: false
name: dATP
constant: false
is: C00131
is: SBO:0000247
boundary condition: false
is: CHEBI:61404
type: Species
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
initial amount: NaN
initial concentration: 1.0

metaR PRAGSr
fast: false
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.1.2.2
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110002#
is: SBO:0000176
type: Reaction
reversible: true
product: MODEL1310110002#
kinetic law: MODEL1310110002#
name: phosphoribosylglycinamide synthase

metaR GLYOp
is described by: ECO:0000000
is: SBO:0000176
reversible: false
name: glycine oxidase, perixosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9038835 NOTES:
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
fast: false

metaM 2decdicoa m
initial concentration: 1.0
has only substance units: false
name: 2,7-decadienoylcoa
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_ccde9783_599e_489d_9339_a58f8774c496
initial amount: NaN
name: ND5
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4540
type: Species
has only substance units: false
constant: false
is: P03915

metaR r1612
product: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
is described by: ECO:0000000
fast: false

metaM hco3 m
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:17544
name: Bicarbonate
type: Species
constant: false
is: C00288
is: HMDB00595
has only substance units: false
is: SBO:0000247
notes: FORMULA: CHO3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00253 EHMN_ABBREVIATION: C00288

metaM lnlncg l
name: gamma-linolenate
constant: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC01757 EHMN_ABBREVIATION: C06426
boundary condition: false
initial concentration: 1.0
is: CHEBI:32391
type: Species
is: HMDB03073
is: SBO:0000247

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_579a4973_5313_4cf4_bd3c_f17c288c59f3
is: E9PCI1
initial amount: NaN
is encoded by: hsa:53
type: Species
name: ACP2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false

metaM g1m8mpdol U r
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
notes: FORMULA: C1785H2940N20O670P20 CHARGE: -20
is: CHEBI:59093
initial concentration: 1.0
constant: false

metaR CYTK10n
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110002#
name: cytidylate kinase (CMP,dGTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
reactant: MODEL1310110002#
is described by: ECO:0000269
fast: false
is: SBO:0000176
kinetic law: MODEL1310110002#
type: Reaction

metaM phe L e
initial concentration: 1.0
name: L-phenylalanine
initial amount: NaN
boundary condition: false
is: HMDB00159
notes: FORMULA: C9H11NO2 CHARGE: 0 INCHI: InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00081 EHMN_ABBREVIATION: C00079
is: CHEBI:17295
is: SBO:0000247
has only substance units: false
constant: false
type: Species

metaR NACDe
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

metaR MECOAS1m
reversible: true
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000176
fast: false
name: mesaconate--CoA ligase (GDP-forming)
type: Reaction
reactant: MODEL1310110002#
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/6.2.1.4
is described by: ECO:0000304

metaR KCC2t
reversible: true
type: Reaction
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (6560.1) or (10723.1) or (9990.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10187864,PMID:10347194,PMID:10600773,PMID:121106695,PMID:12657561,PMID:8663127 NOTES:NCD
is: SBO:0000185
name: K+-Cl- cotransporter (NH4+)
is described by: ECO:0000269
modifier: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_976fe6e7_3765_4338_92f8_c31d7d79d784
is: SBO:0000252
is: Q14032
is encoded by: hsa:570
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
type: Species
name: BAAT

metaR KSIt
name: keratan sulfate I transport, golgi to extracellular
product: MODEL1310110002#
reversible: false
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#

metaM ksi pre33 g
is: C00130
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
initial concentration: 1.0
boundary condition: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 33
constant: false
is: SBO:0000247
is: HMDB00175
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_9073f6b8_3162_44e1_b983_0b2c8d01ee90
is: SBO:0000252
is encoded by: hsa:160851
type: Species
is: A8K0I1
initial concentration: NaN
constant: false
boundary condition: true
name: DGKH
initial amount: NaN
has only substance units: false

metaR M1316Mg
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
kinetic law: MODEL1310110002#
fast: false
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
product: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.114
reactant: MODEL1310110002#
is: SBO:0000176

metaM adrncoa c
constant: false
name: adrenyl coenzyme A
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: C16170
is: http://identifiers.org/pubchem.compound/47205480
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_79f7a9b4_d4d3_44df_afc5_63af8ab30857
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:3032
name: HADHB
boundary condition: true
constant: false
is: SBO:0000252
is: P55084
type: Species

metaM dec47dicoa m
constant: false
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: 4,7-decadienoylcoa
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

metaM cspg c e
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
constant: false
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan
is: SBO:0000247
is: HMDB00630
boundary condition: false
is: CHEBI:16040
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_b9fefdb2_4bba_4581_ac21_7b3c8a970b75
type: Species
boundary condition: true
name: B3GNT4
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: Q9C0J1
is: SBO:0000252
is encoded by: hsa:79369

metaM retinal 11 cis c
type: Species
has only substance units: false
initial amount: NaN
is: HMDB02152
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: CHEBI:16066
constant: false
name: 11-cis-retinal

http://identifiers.org/biomodels.db/MODEL1310110002#_fda7269b_0582_4a07_aaac_38256844aa78
boundary condition: true
has only substance units: false
initial amount: NaN
is: H7C5B8
is: SBO:0000252
type: Species
name: NDUFB2
initial concentration: NaN
is encoded by: hsa:4708
constant: false

metaM glu5sa m
is: C01165
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:17232
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
initial concentration: 1.0
name: L-Glutamate 5-semialdehyde
is: HMDB02104
boundary condition: false

metaM dttp e
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01342
is: SBO:0000247
is: CHEBI:37568
name: dTTP(4-)
constant: false
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 INCHI: InChI=1S/C10H17N2O14P3/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(24-8)4-23-28(19,20)26-29(21,22)25-27(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,21,22)(H,11,14,15)(H2,16,17,18)/p-4/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
initial amount: NaN
has only substance units: false

metaR CHATn
reversible: true
type: Reaction
modifier: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (1103.4) or (1103.1) or (1103.3) or (1103.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:NJ
name: Choline O-acetyltransferase
reactant: MODEL1310110002#
product: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.6

metaM met L e
has only substance units: false
type: Species
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
name: L-methionine
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16643
boundary condition: false
is: SBO:0000247
is: HMDB00696
constant: false

metaM xolest2 hs e
name: cholesterol ester
type: Species
is: CHEBI:17002
initial amount: NaN
has only substance units: false
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_2a215b8b_afff_48dd_acb2_41ecf192ddcd
is: P27708
name: CAD
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:790
initial amount: NaN

metaR CSNt
is: SBO:0000185
modifier: MODEL1310110002#
product: MODEL1310110002#
name: cytosine transport via facilated diffusion
fast: false
reversible: true
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
kinetic law: MODEL1310110002#
is described by: ECO:0000269
type: Reaction

metaR B3GNT36g
reactant: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
fast: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
modifier: MODEL1310110002#

metaR r1610
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110002#
reversible: true
fast: false
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000

metaR r1431
reactant: MODEL1310110002#
product: MODEL1310110002#
reversible: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
name: 2-Deoxyuridine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Pyrimidine metabolism EC:1.17.4.1

metaR r0669
product: MODEL1310110002#
kinetic law: MODEL1310110002#
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17
reactant: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
fast: false

metaR RE2799C
type: Reaction
reactant: MODEL1310110002#
reversible: true
product: MODEL1310110002#
is: SBO:0000176
name: RE2799
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 1.1.1.188 Confidence Level: 0 AUTHORS: PMID:12543809,PMID:7948008 NOTES:
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_9a5d30af_3014_42c4_abe0_c4b33798fe73
constant: false
is encoded by: hsa:AV713053
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
name: _AV713053_1_m

metaM ksi pre15 g
is: C00130
notes: FORMULA: C149H240N10O119S4X CHARGE: -5
boundary condition: false
is: HMDB00175
is: CHEBI:58053
is: SBO:0000247
type: Species
has only substance units: false
constant: false
name: keratan sulfate I biosynthesis, precursor 15
initial concentration: 1.0
initial amount: NaN

metaR LPS2e
type: Reaction
fast: false
name: lipase, extracellular
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (3990.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.1.3 Confidence Level: 2 AUTHORS: PMID:14630921 NOTES:carbonyl and extra H accounted for in R group NJ
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_f460c151_2564_4835_ada2_68a3fe3d2289
initial concentration: NaN
initial amount: NaN
name: SGPL1
is: O95470
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:8879

metaR r0556
kinetic law: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
is described by: ECO:0000000
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
is version of: http://identifiers.org/ec-code/1.14.19.1
is: SBO:0000176
modifier: MODEL1310110002#
fast: false

metaM atp e
initial amount: NaN
is: SBO:0000247
name: ATP(4-)
is: C00002
constant: false
type: Species
is: CHEBI:57299
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00538

metaM ala D c
boundary condition: false
name: D-alanine
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:15570
initial concentration: 1.0
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
is: HMDB01310

metaR S6T6g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reversible: false
reactant: MODEL1310110002#
is described by: ECO:0000000

metaM dchac e
constant: false
name: deoxycholic acid
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C24H39O4 CHARGE: -1
is: SBO:0000247
is: HMDB00626

http://identifiers.org/biomodels.db/MODEL1310110002#_7b2e5b2c_9ae3_46d1_8fe5_e0e0fdb01079
name: _AW299740_1_m
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:AW299740
initial concentration: NaN

metaR DCK2n
reactant: MODEL1310110002#
modifier: MODEL1310110002#
product: MODEL1310110002#
name: Deoxycytidine kinase, nuclear (UTP)
is: SBO:0000176
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
fast: false
kinetic law: MODEL1310110002#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.74
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_a9417415_5516_461a_8270_baa93e56c2f1
constant: false
is: Q9Y2Q0
name: ATP8A1
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:10396
has only substance units: false
is: SBO:0000252

metaR PSFLIPm
reversible: false
is version of: http://identifiers.org/ec-code/3.6.3.1
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
is described by: ECO:0000269
fast: false
product: MODEL1310110002#
is: SBO:0000185
name: phosphatidylserine flippase
modifier: MODEL1310110002#

metaM dcyt n
has only substance units: false
name: 2'-deoxycytidine
is: SBO:0000247
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
constant: false
initial amount: NaN
is: HMDB00014
boundary condition: false
initial concentration: 1.0
is: CHEBI:15698
type: Species

metaR P45027A1m
reactant: MODEL1310110002#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: Cytochrome P450 27
is version of: http://identifiers.org/ec-code/1.14.13.15
reversible: false
modifier: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#

metaR AG13T6g
kinetic law: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149

metaR CO2tm
is described by: ECO:0000000
reversible: true
name: CO2 transport (diffusion), mitochondrial
is: SBO:0000185
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3081508 NOTES:IF
kinetic law: MODEL1310110002#
fast: false
type: Reaction
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_3023fb0a_9508_4851_b0b4_e08713543d4d
type: Species
is: Q308M7
name: ENPP3
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:5169
initial amount: NaN
has only substance units: false

metaR S6T4g
kinetic law: MODEL1310110002#
reversible: false
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_394eabad_e4f4_4354_9eda_5a26476d2e2e
is: Q6UVY6
boundary condition: true
name: MOXD1
initial amount: NaN
is encoded by: hsa:26002
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species

metaR HPYRR2x
modifier: MODEL1310110002#
is described by: ECO:0000304
product: MODEL1310110002#
kinetic law: MODEL1310110002#
name: hydroxypyruvate reductase (NADH)
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.2.4
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (3948.1) or (197257.1) or (3945.1) or (160287.1) or (3945.1 and 3939.1) or (92483.1) or (3939.1) or (197257.2) or (3948.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:14635115,PMID:5635456 NOTES:NCD
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110002#_fcf69d70_5647_4886_b5eb_b7fc0641e718
boundary condition: true
name: PYCR1
has only substance units: false
type: Species
is encoded by: hsa:5831
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is: A6NFM2
constant: false

metaR TYRTA
type: Reaction
modifier: MODEL1310110002#
name: tyrosine transaminase
is version of: http://identifiers.org/ec-code/2.6.1.1
is: SBO:0000176
kinetic law: MODEL1310110002#
fast: false
reversible: true
is described by: ECO:0000269
product: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Tyrosine metabolism EC Number: 2.6.1.5 Confidence Level: 4 AUTHORS: NOTES:

metaR XYLt
is: SBO:0000185
modifier: MODEL1310110002#
name: D-xylose reversible transport
is described by: ECO:0000269
reactant: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (6515.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
reversible: true
kinetic law: MODEL1310110002#
fast: false
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEtg
kinetic law: MODEL1310110002#
is: SBO:0000185
reactant: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
name: blood group intracellular transport

metaM acetone e
is: HMDB01659
initial amount: NaN
name: acetone
constant: false
has only substance units: false
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
boundary condition: false
initial concentration: 1.0
type: Species
is: CHEBI:15347
is: SBO:0000247

metaM bhb c
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: CHEBI:10983
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00011
constant: false
is: SBO:0000247
boundary condition: false
type: Species
name: (R)-3-hydroxybutyrate

metaR PETOHMm hs
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
modifier: MODEL1310110002#
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
name: phosphatidylethanolamine N-methyltransferase
is: SBO:0000176
is described by: ECO:0000254
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.1.1.17

metaM hmgcoa c
has only substance units: false
name: Hydroxymethylglutaryl-CoA
constant: false
boundary condition: false
is: CHEBI:15467
is: SBO:0000247
initial concentration: 1.0
is: HMDB01375
initial amount: NaN
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
type: Species

metaM Tn antigen g
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C8H14NO5X CHARGE: 0
name: Tn antigen
has only substance units: false
is: C04383
is: SBO:0000247
constant: false

metaR r0909
type: Reaction
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
name: Transport reaction
reversible: true
product: MODEL1310110002#
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110002#

metaR r1365
fast: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: false
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR S6T10g
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
kinetic law: MODEL1310110002#
is: SBO:0000176
reactant: MODEL1310110002#
reversible: false
product: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
modifier: MODEL1310110002#

metaR EX bhb LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate transport via H+ symport
type: Reaction

metaR PPAt
is described by: ECO:0000000
reactant: MODEL1310110002#
reversible: false
name: Propionate transport, diffusion
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8135845 NOTES:TDV
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110002#

metaM maltttr e
name: Maltotetraose
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/5141
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C02052
initial concentration: 1.0
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052
is: HMDB01296
boundary condition: false

metaR CERT2rt
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
reactant: MODEL1310110002#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000185
fast: false
product: MODEL1310110002#
name: ceramide transport protein
reversible: true
type: Reaction
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#

metaM 2ddecdicoa m
name: 2,6-dodecadienoylcoa
is: SBO:0000247
boundary condition: false
is: HMDB11123
has only substance units: false
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
initial amount: NaN
initial concentration: 1.0
constant: false
type: Species
is: C05279

metaM estrones c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB01425
type: Species
name: estrone 3-sulfate(1-)
is: CHEBI:60050
constant: false
notes: FORMULA: C18H21O5S CHARGE: -1 INCHI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/p-1/t14-,15-,16+,18+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00961 EHMN_ABBREVIATION: C02538
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_87cbf616_a33d_49f1_ad8f_9c0895f53a58
name: SLC33A1
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: O00400
constant: false
is encoded by: hsa:9197
has only substance units: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_678c5524_489f_460b_8e7a_5200ab63cda9
has only substance units: false
initial concentration: NaN
type: Species
name: SLC3A2
constant: false
is: SBO:0000252
initial amount: NaN
is: P08195
is encoded by: hsa:6520
boundary condition: true

metaR AK2LGCHOLt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.1.1.21 Confidence Level: 2 AUTHORS: PMID:2004782,PMID:2253271,PMID:8106516 NOTES:
product: MODEL1310110002#
name: 1-alkyl 2-acylglycerol 3-phosphocholine transport
kinetic law: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110002#
fast: false
type: Reaction

metaM pe hs e
is: CHEBI:16038
boundary condition: false
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
name: phosphatidylethanolamine

http://identifiers.org/biomodels.db/MODEL1310110002#_55767c6b_5eea_4953_b932_cda5db1cb5ba
name: _AV727634_1_c
type: Species
has only substance units: false
is encoded by: hsa:AV727634
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN

metaM hexdicoa r
constant: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: hexadecanedioylcoa
is: SBO:0000247
is: C08260
is: HMDB00672
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
type: Species
boundary condition: false

metaM ethamp c
constant: false
type: Species
has only substance units: false
is: CHEBI:58190
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C2H7NO4P CHARGE: -1 INCHI: InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00293 EHMN_ABBREVIATION: C00346
is: HMDB00224
name: ethamp[c]
initial amount: NaN
is: SBO:0000247

metaR RE0830C
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
reactant: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
is described by: ECO:0000000
name: RE0830
is: SBO:0000176
fast: false
reversible: true

metaM HC01376 m
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:28692
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
name: S-(2-Methylbutanoyl)-dihydrolipoamide
notes: FORMULA: C13H25NO2S2 CHARGE: 0 INCHI: InChI=1S/C13H25NO2S2/c1-3-10(2)13(16)18-9-8-11(17)6-4-5-7-12(14)15/h10-11,17H,3-9H2,1-2H3,(H2,14,15) EHMN_ABBREVIATION: C05118

metaR r0908
product: MODEL1310110002#
type: Reaction
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
reactant: MODEL1310110002#
reversible: true
name: Postulated transport reaction
is described by: ECO:0000000
kinetic law: MODEL1310110002#

metaR r2079
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
modifier: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
reactant: MODEL1310110002#
is: SBO:0000185

metaR r1364
name: Vesicular transport
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110002#
product: MODEL1310110002#
reversible: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110002#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_1a935dbb_15fe_4d58_bea1_240f63b70566
is encoded by: hsa:3098
type: Species
is: Q59FD4
name: HK1
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true
initial amount: NaN

metaM malthp e
constant: false
is: C01936
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/5041
notes: FORMULA: C42H72O36 CHARGE: 0 INCHI: InChI=1/C42H72O36/c43-1-8-15(50)16(51)24(59)37(67-8)74-31-10(3-45)69-39(26(61)18(31)53)76-33-12(5-47)71-41(28(63)20(33)55)78-35-14(7-49)72-42(29(64)22(35)57)77-34-13(6-48)70-40(27(62)21(34)56)75-32-11(4-46)68-38(25(60)19(32)54)73-30-9(2-44)66-36(65)23(58)17(30)52/h8-65H,1-7H2/t8-,9-,10-,11-,12-,13-,14-,15+,16+,17-,18-,19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+,35+,36u,37+,38+,39+,40+,41+,42+/m1/s1 EHMN_ABBREVIATION: CE2837
initial amount: NaN
boundary condition: false
name: maltoheptaose
is: SBO:0000247
has only substance units: false

metaM tmndnccoa m
initial concentration: 1.0
name: timnodonyl coenzyme A
type: Species
boundary condition: false
notes: FORMULA: C41H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C41H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h5-6,8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4,7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b6-5-,9-8-,12-11-,15-14-,18-17-/t30-,34-,35?,36+,40-/m1/s1
constant: false
initial amount: NaN
has only substance units: false
is: HMDB06514
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_98e62e8b_39f1_4d6b_9512_09d5650f8725
is encoded by: hsa:2588
is: SBO:0000252
constant: false
is: P34059
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: GALNS

metaM acetone c
is: SBO:0000247
is: HMDB01659
has only substance units: false
initial amount: NaN
name: acetone
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:15347

http://identifiers.org/biomodels.db/MODEL1310110002#_94cc8c50_bc00_439e_91fc_2b7299752ad0
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: RHAG
is encoded by: hsa:6005
type: Species
is: SBO:0000252
has only substance units: false
is: Q96E98

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_metaR_ACGALFUCGALACGALFUCGALACGLCGAL14ACGLCGALGLUSIDEte
reactant: MODEL1310110002#
type: Reaction
is: SBO:0000185
name: blood group intracellular transport
product: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
reversible: true

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaR r0317
product: MODEL1310110002#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.8.1.4
modifier: MODEL1310110002#
reversible: true
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.2.10
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110002#
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reactant: MODEL1310110002#

metaM CE1944 c
initial concentration: 1.0
is: CHEBI:36781
notes: FORMULA: C4H8N CHARGE: 1 INCHI: InChI=1S/C4H7N/c1-2-4-5-3-1/h3H,1-2,4H2/p+1 EHMN_ABBREVIATION: CE1944
boundary condition: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
name: 1-pyrrolinium
constant: false

metaR AG13T11g
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
reactant: MODEL1310110002#

metaR EX val L LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Valine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_f67b4edf_3f0a_43f0_8ec1_c19b15f498de
boundary condition: true
name: SUCLG2:SUCLG1
has part: P53597
is encoded by: hsa:8802
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:8801
has only substance units: false
has part: Q96I99
constant: false
initial concentration: NaN
type: Species

metaM 3mop c
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
name: 3-methyl-2-oxopentanoate
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
initial concentration: 1.0
is: HMDB00491
is: CHEBI:28654

metaR r0998
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reactant: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
name: Facilitated diffusion
kinetic law: MODEL1310110002#
fast: false

metaR r1291
reversible: true
fast: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
name: Postulated transport reaction
type: Reaction
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaR MMSAD3m
product: MODEL1310110002#
reversible: false
modifier: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.27
is: SBO:0000176
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093,PMID:6418146 NOTES:also EC 1.2.1.18 - NCD
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_fucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: CHEBI:61648
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
is: SBO:0000247
boundary condition: false
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)2 (Cer)1

http://identifiers.org/biomodels.db/MODEL1310110002#_e1a92824_41b6_456a_a4ec_dae736d21286
initial concentration: NaN
is encoded by: hsa:R33828
name: _R33828_1_c
constant: false
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_3948da45_21f2_4ffd_9703_362708c99bbd
constant: false
name: GOT1
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: P17174
is: SBO:0000252
is encoded by: hsa:2805
type: Species

metaM lnlccrn c
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
name: Linoleyl carnitine
has only substance units: false
is: HMDB06469
initial amount: NaN
is: SBO:0000247

metaM cs d deg2 l
has only substance units: false
boundary condition: false
is: HMDB00812
is: CHEBI:16953
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C37H53NO44S4 CHARGE: -6
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 2
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_0878b8eb_91b9_49cd_8e06_d46552b5fdab
is encoded by: hsa:6470
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: SHMT1
constant: false
initial amount: NaN
has only substance units: false

metaM bilglcur c
has only substance units: false
is: SBO:0000247
is: CHEBI:57767
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
boundary condition: false
name: mono(glucosyluronic acid)bilirubin(2-)
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374

metaM succoa x
is: HMDB01022
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: Succinyl-CoA
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
constant: false
is: SBO:0000247
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_6bea5a7f_706f_4921_b3cf_69155dabcc45
is encoded by: hsa:3101
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P52790
boundary condition: true
has only substance units: false
constant: false
name: HK3
type: Species

metaM 10fthf6glu e
type: Species
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
constant: false
is: CHEBI:57454
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: 10-formyltetrahydrofolate-[Glu](6)
has only substance units: false
is: HMDB00972
boundary condition: false

metaM pe hs c
boundary condition: false
is: CHEBI:16038
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
name: phosphatidylethanolamine
type: Species
initial amount: NaN
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110002#_d6a867fb_44a6_4df5_96ff_db4df5a3b2f5
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:6582
constant: false
name: SLC22A2
initial amount: NaN

metaM trdox m
initial amount: NaN
is: SBO:0000247
is: CHEBI:18191
has only substance units: false
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
type: Species
constant: false
initial concentration: 1.0
name: Oxidized thioredoxin
boundary condition: false

metaR r0999
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
is described by: ECO:0000000
name: Facilitated diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
product: MODEL1310110002#

metaM dhap x
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: http://identifiers.org/pubchem.compound/3411
is: C00111
name: Dihydroxyacetone phosphate
is: HMDB01473
initial concentration: 1.0
constant: false
is: CHEBI:57642

metaR RE2269E
is: SBO:0000176
reactant: MODEL1310110002#
name: RE2269
reversible: true
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
product: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.21.39
kinetic law: MODEL1310110002#
fast: false
modifier: MODEL1310110002#
is described by: ECO:0000000

metaM pi r
type: Species
is: C00009
initial concentration: 1.0
initial amount: NaN
name: hydrogenphosphate
boundary condition: false
is: HMDB00973
constant: false
has only substance units: false
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_82e9f4a0_7ba6_47f4_9daa_71c719d5e398
is: Q53HM1
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:54963
name: UCKL1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_galacglc13galacglcgal14acglcgalgluside_hs_g
notes: FORMULA: C72H125N4O42FULLRCO CHARGE: 0
name: nLc8Cer
is: CHEBI:26174
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_27bfdef2_3cdf_49e9_8a2e_9fd48c87ad7e
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:55568
is: Q86SR1
initial concentration: NaN
name: GALNT10
constant: false
boundary condition: true
initial amount: NaN

metaM Tn antigen l
initial concentration: 1.0
constant: false
is: C04383
initial amount: NaN
name: Tn antigen
is: SBO:0000247
notes: FORMULA: C8H14NO5X CHARGE: 0
boundary condition: false
type: Species
has only substance units: false

metaM datp c
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:61404
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
has only substance units: false
type: Species
is: HMDB01532
is: C00131
boundary condition: false
initial concentration: 1.0
name: dATP

http://identifiers.org/biomodels.db/MODEL1310110002#_61cb155b_04d5_4bcb_b99a_633ed127d6c4
type: Species
is: A7E2E0
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:5293
name: PIK3CD
initial amount: NaN

metaR MM7Cbg
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110002#
is: SBO:0000176
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.113
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD

MODEL1310110002#
species: metaM 4hpro LT m
species: metaM HC00591 c
species: metaM 25aics c
species: metaM acetone c
species: metaM cys L e
species: metaM CE4794 m
species: metaM sphmyln hs c
species: metaM pail5p hs c
species: metaM 4h2oglt m
species: metaM xyl D l
species: metaM g6p c
species: metaM strdnc r
species: metaM gal l
species: metaM thyox L c
species: metaM udpacgal g
species: metaM s2l2fn2m2masn e
species: metaM icit m
species: metaM ksi pre16 g
species: metaM aacoa m
species: metaM arachdcoa c
species: metaM tdchola c
name: PIK3CB:PIK3R1
species: metaM gdp n
species: metaM dgtp m
species: metaM asp D e
species: metaM 2decdicoa m
species: metaM nad x
species: metaM alpam m
species: metaM pail4p hs n
species: metaM q10 c
species: metaM methf m
species: metaM tststerone e
species: metaM 10fthf7glu e
type: Species
species: metaM g3m8mpdol U r
species: metaM ump c
species: metaM ksi pre2 g
species: metaM gam c
species: metaM pyr m
species: metaM betald c
species: metaM itacon m
species: metaM ksi pre18 g
species: metaM udp n
species: metaM gbside hs g
species: metaM hexdiac c
species: metaM HC00361 c
stoichiometry: 0.020401
species: metaM hdcea l
species: metaM ksi pre36 g
species: metaM ctp m
scale: -3
species: metaM mag hs e
species: metaM nm4masn g
species: metaM HC02210 c
species: metaM dcdp n
species: metaM fad e
species: metaM andrstrn r
species: metaM lac L e
species: metaM cytd c
species: metaM HC01115 c
species: metaM leugly e
species: metaM ksi pre25 g
species: metaM 1p3h5c m
species: metaM thym c
species: metaM dtdp e
species: metaM leuktrB4 e
species: metaM 5tedtricoa m
species: metaM galacglcgalgbside hs c
species: metaM cdpdag hs c
species: metaM frdp c
species: metaM C05957 r
stoichiometry: 3.0
species: metaM HC02217 e
species: metaM ksii core2 deg2 l
species: metaM co2 c
species: metaM cmp c
species: metaM pi e
species: metaM ps hs e
species: metaM ala L e
species: metaM adp n

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

metaR DNDPt15m
modifier: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000269
reversible: false
name: dUDP transport via dGDP antiport
fast: false
product: MODEL1310110002#
is: SBO:0000185

metaR UMPK6n
is: SBO:0000176
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110002#
is described by: ECO:0000269
product: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dCTP),nuclear

metaM biocyt m
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
constant: false
type: Species
name: Biocytin
initial concentration: 1.0
is: SBO:0000247
is: C05552
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/7886
boundary condition: false
is: HMDB03134

http://identifiers.org/biomodels.db/MODEL1310110002#_57e98645_d171_433c_b768_b5257473013f
initial concentration: NaN
is: SBO:0000252
name: ALDH1A3
is: P47895
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:220
initial amount: NaN
constant: false

metaM prostgd2 r
type: Species
constant: false
is: HMDB01403
boundary condition: false
is: CHEBI:57406
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
name: prostaglandin D2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696

metaM dolp U c
boundary condition: false
is: SBO:0000247
name: dolichyl phosphate(2-)
type: Species
initial amount: NaN
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial concentration: 1.0
has only substance units: false
is: CHEBI:57683
constant: false

metaR G14T14g
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
product: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_e47841aa_d1d4_4a1c_b994_6058650fffdf
name: MDH2
initial concentration: NaN
initial amount: NaN
is: P40926
is encoded by: hsa:4191
is: SBO:0000252
boundary condition: true
constant: false
type: Species
has only substance units: false

metaM zymstnl r
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
is: CHEBI:16608
is: HMDB06841
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 5alpha-cholest-8-en-3beta-ol
type: Species
boundary condition: false
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_4b7f951a_2819_4e0b_8b17_8fcba0d48aa3
type: Species
boundary condition: true
is encoded by: hsa:54344
name: DPM3
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: Q9P2X0

metaR HMGLx
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3155.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:TV NJ added peroxisomal version - see Olivier Biochimica et Biophysica Act 1529 (2000) 89-102
is described by: ECO:0000134
kinetic law: MODEL1310110002#
reversible: false
product: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.3.4
reactant: MODEL1310110002#
modifier: MODEL1310110002#
name: hydroxymethylglutaryl-CoA lyase

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR r0311
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
fast: false
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.9
product: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaR EX HC00822 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chitobiose exchange
type: Reaction

metaM HC01412 m
boundary condition: false
initial concentration: 1.0
type: Species
name: trans-tetradec-2-enoyl-CoA(4-)
notes: FORMULA: C35H56N7O17P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h14-15,22-24,28-30,34,45-46H,4-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b15-14+/t24-,28-,29-,30+,34-/m1/s1 EHMN_ABBREVIATION: C05273
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:61405

http://identifiers.org/biomodels.db/MODEL1310110002#_2a6cdb25_2228_41e2_b978_43daa1894180
initial amount: NaN
constant: false
name: _M68895_1_c
is encoded by: hsa:M68895
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_be509ad5_8602_4c1c_9b93_2a81e052353d
is encoded by: hsa:27124
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: INPP5J
type: Species
boundary condition: true

metaM dolmanp U r
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:15809
boundary condition: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
type: Species
initial amount: NaN
name: Dolichyl phosphate D-mannose, human uterine homolog

metaM HC00342 c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:16383
boundary condition: false
type: Species
name: cis-aconitate(3-)
constant: false
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
is: SBO:0000247

metaM bilglcur e
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:57767
is: SBO:0000247
has only substance units: false
notes: FORMULA: C39H44N4O12 CHARGE: 0 INCHI: InChI=1S/C39H44N4O12/c1-7-20-19(6)36(50)43-27(20)14-25-18(5)23(10-12-31(46)54-39-34(49)32(47)33(48)35(55-39)38(52)53)29(41-25)15-28-22(9-11-30(44)45)17(4)24(40-28)13-26-16(3)21(8-2)37(51)42-26/h7-8,13-14,32-35,39-41,47-49H,1-2,9-12,15H2,3-6H3,(H,42,51)(H,43,50)(H,44,45)(H,52,53)/p-2/b26-13+,27-14+/t32-,33-,34+,35-,39+/m0/s1 EHMN_ABBREVIATION: C03374
type: Species
initial concentration: 1.0
name: mono(glucosyluronic acid)bilirubin(2-)

http://identifiers.org/biomodels.db/MODEL1310110002#_5b6b8bd7_cb62_4876_81ba_783959c3dd51
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is: E9PB82
is encoded by: hsa:3295
initial amount: NaN
name: HSD17B4
initial concentration: NaN
boundary condition: true

metaR SO4t4 2
reactant: MODEL1310110002#
name: sulfate transport via sodium symport
product: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (26266.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10535998,PMID:15607730 NOTES:NCD
reversible: true
type: Reaction
is described by: ECO:0000269
is: SBO:0000185

metaR PI4PLC
is version of: http://identifiers.org/ec-code/3.1.4.11
fast: false
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
name: phosphatidylinositol 4-phosphate phospholipase C
reversible: false
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
product: MODEL1310110002#
reactant: MODEL1310110002#

metaM 3dsphgn c
initial concentration: 1.0
is: CHEBI:58299
is: HMDB01480
has only substance units: false
name: (2S)-1-hydroxy-3-oxooctadecan-2-aminium
constant: false
notes: FORMULA: C18H38NO2 CHARGE: 1 INCHI: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17,20H,2-16,19H2,1H3/p+1/t17-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01019 EHMN_ABBREVIATION: C02934
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR ACOAO7p
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
product: MODEL1310110002#
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110002#
modifier: MODEL1310110002#
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110002#_27e659a1_0c5c_4ddd_99f7_d7d1578a72b9
boundary condition: true
name: FUT8
is encoded by: hsa:2530
initial amount: NaN
is: Q9BYC5
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252

metaR EX cgly LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cys-Gly exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_cfd480c2_e77f_43b9_9c38_b471fba6430d
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is: P14060
boundary condition: true
is encoded by: hsa:3283
initial concentration: NaN
name: HSD3B1
has only substance units: false

metaR r0310
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
name: Palmitoyl-CoA:oxygen 2-oxidoreductase Fatty acid metabolism EC:1.3.3.6 EC:1.3.99.3
type: Reaction
reversible: false
fast: false
product: MODEL1310110002#

metaM CE5101 m
type: Species
is: CHEBI:57795
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
initial amount: NaN
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

metaR RNDR1
reversible: false
kinetic law: MODEL1310110002#
name: ribonucleoside-diphosphate reductase (ADP)
modifier: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1
type: Reaction
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 2 AUTHORS: PMID:14729598 NOTES:
fast: false
is described by: ECO:0000254
product: MODEL1310110002#

metaR NCKt
kinetic law: MODEL1310110002#
is described by: ECO:0000269
fast: false
reactant: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
type: Reaction
modifier: MODEL1310110002#
product: MODEL1310110002#
name: Na+/Ca2+-K+ exchange
reversible: true

metaR FAOXC123C102m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaM bhb e
is: CHEBI:10983
boundary condition: false
has only substance units: false
is: HMDB00011
constant: false
type: Species
initial concentration: 1.0
name: (R)-3-hydroxybutyrate
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089

metaR ACGAMK
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.1.59
is: SBO:0000176
name: N-acetylglucosamine kinase
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.59 Confidence Level: 4 AUTHORS: PMID:10824116 NOTES:
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110002#
fast: false

metaR MMTSADm
name: malonate-semialdehyde dehydrogenase (acetylating), mitochondrial
is: SBO:0000176
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1527093 NOTES:MM. biochemical activity measured in rat, sequence similarity found in human
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110002#
reactant: MODEL1310110002#

metaM idp c
is: HMDB03335
is: SBO:0000247
initial concentration: 1.0
name: IDP(3-)
constant: false
boundary condition: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:58280

metaR 2DR1PP
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.1.3.10 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110002#
name: 2-deoxy-D-ribose 1-phosphate phosphorylase
is: SBO:0000176
reversible: false
product: MODEL1310110002#
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_2c185354_ad92_42c9_a4f9_a403a9510af2
initial concentration: NaN
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: ALAS2
boundary condition: true
is encoded by: hsa:212
is: Q5JZF5

metaR G14T20g
type: Reaction
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110002#
fast: false
reversible: false

metaM fum c
boundary condition: false
is: C00122
type: Species
constant: false
has only substance units: false
is: CHEBI:29806
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
name: Fumarate
is: HMDB00134
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_ff5c81c3_8d49_47cd_8260_663a73af87f7
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: NDUFA8
boundary condition: true
is: B1AM93
is encoded by: hsa:4702

metaM arachdcoa c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB06523
is: CHEBI:57368
type: Species
constant: false
name: arachidonoyl-CoA(4-)
notes: FORMULA: C41H62N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,17-18,28-30,34-36,40,51-52H,4-7,10,13,16,19-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/p-4/b9-8-,12-11-,15-14-,18-17-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01986 EHMN_ABBREVIATION: C02249

http://identifiers.org/biomodels.db/MODEL1310110002#_886ff501_9da6_49c4_8f9e_b6f20a687a20
type: Species
name: SLC2A3
constant: false
boundary condition: true
is: P11169
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6515
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_f113670b_d097_47b4_86a0_0fadfca071ce
name: NDUFB1
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: O75438
is encoded by: hsa:4707

metaM ksi pre23 g
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
is: SBO:0000247
is: CHEBI:28067
name: keratan sulfate I biosynthesis, precursor 23

metaM estrones e
initial concentration: 1.0
is: SBO:0000247
name: estrone 3-sulfate(1-)
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H21O5S CHARGE: -1 INCHI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/p-1/t14-,15-,16+,18+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00961 EHMN_ABBREVIATION: C02538
is: CHEBI:60050
is: HMDB01425
constant: false

metaM CE2434 m
constant: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,18-19,26-28,32-34,38,49-50H,4-7,10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2434
has only substance units: false
is: SBO:0000247
name: trans,cis,cis-2,9,12-octadecatrienoyl-CoA
is: CHEBI:57795
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_1de26e19_65f2_4ac2_8797_4946101eea28
initial concentration: NaN
is encoded by: hsa:3939
initial amount: NaN
is: P00338
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
constant: false
name: LDHA

metaR r1418
product: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110002#

metaM cmpacna c
is: CHEBI:57812
name: CMP-N-acetyl-beta-neuraminate(2-)
boundary condition: false
initial concentration: 1.0
is: HMDB01176
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_94e67dfa_8c2b_49f3_bcf2_273230c6f0d8
constant: false
name: MTMR3
is: SBO:0000252
type: Species
is encoded by: hsa:8897
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR RE1233C
notes: GENE_ASSOCIATION: (883.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 0 AUTHORS: PMID:10756023 NOTES:IT - removed H[c] on right hand side
reactant: MODEL1310110002#
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.64
product: MODEL1310110002#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
name: RE1233

metaR r0196
is described by: ECO:0000000
product: MODEL1310110002#
type: Reaction
reversible: true
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
is version of: http://identifiers.org/ec-code/3.6.1.5
reactant: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
fast: false

metaR RNDR3
product: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
type: Reaction
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
name: ribonucleoside-diphosphate reductase (CDP)
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (6240.1 and 6241.1) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.14.1 Confidence Level: 4 AUTHORS: PMID:14729598 NOTES:
fast: false
is described by: ECO:0000269

metaR HEX10
name: hexokinase (D-glucosamine:ATP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.2
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2645.1) or (3099.1) or (3098.3) or (2645.2) or (80201.1) or (3098.2) or (2645.3) or (3098.1) or (3098.4) or (3101.1) or (3098.5) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.1 Confidence Level: 1 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase.
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
modifier: MODEL1310110002#
product: MODEL1310110002#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.1

metaR EX pectindchac LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectin-deoxycholic acid complex
type: Reaction

metaR PPAm
notes: GENE_ASSOCIATION: (27068.4) or (27068.1) or (27068.3) or (27068.2) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:IF
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/3.6.1.1
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110002#
name: inorganic diphosphatase
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
product: MODEL1310110002#

metaM q10h2 m
initial concentration: 1.0
type: Species
is: HMDB13111
constant: false
name: Ubiquinol-10
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/6504740
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_0101c932_83b8_4935_a84c_6927ca4fb434
type: Species
is: SBO:0000252
name: NADSYN1
has only substance units: false
is encoded by: hsa:55191
initial amount: NaN
initial concentration: NaN
constant: false
is: Q6IA69
boundary condition: true

metaR CSNATp
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 2 AUTHORS: PMID:7829107 NOTES:NCD
kinetic law: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
reversible: true
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.7
is: SBO:0000176
fast: false

metaR ASNtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
is: SBO:0000185
kinetic law: MODEL1310110002#
name: L-asparagine transport, mitochondrial
is described by: ECO:0000000
type: Reaction
product: MODEL1310110002#
fast: false
reversible: false
reactant: MODEL1310110002#

metaR FUMtm
is described by: ECO:0000269
fast: false
type: Reaction
reversible: true
reactant: MODEL1310110002#
name: fumarate transport, mitochondrial
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_afad839b_aab6_46f1_8f99_8846f1e599d4
boundary condition: true
constant: false
has only substance units: false
name: COASY
is: SBO:0000252
is encoded by: hsa:80347
type: Species
is: Q13057
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_84426158_ea5c_4d00_ba48_0c01f4812166
boundary condition: true
constant: false
is encoded by: hsa:8875
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false
name: VNN2
is: A8K7W0

metaM dhf e
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial concentration: 1.0
type: Species
is: CHEBI:57451
has only substance units: false
boundary condition: false
name: dihydrofolate(2-)
is: SBO:0000247
constant: false
is: HMDB01056
initial amount: NaN

metaR DHCR72r
reversible: false
modifier: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
name: 7-dehydrocholesterol reductase
reactant: MODEL1310110002#
is described by: ECO:0000269
fast: false
product: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.1.21

http://identifiers.org/biomodels.db/MODEL1310110002#_e5d8b339_cfa2_43db_93b0_a061abeafcfb
name: HAO2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:51179
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species

metaM acetone m
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:15347
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
type: Species
is: HMDB01659
initial concentration: 1.0
boundary condition: false
name: acetone
constant: false

metaR RE1523M
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1523
is: SBO:0000176
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35

metaR GNDer
is described by: ECO:0000000
kinetic law: MODEL1310110002#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
name: phosphogluconate dehydrogenase, endoplasmic reticulum
reactant: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
reversible: false

metaR ARAB Lt
is described by: ECO:0000000
type: Reaction
name: L-arabinoase extracellular transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
is: SBO:0000185

metaR MTHFDm
reversible: true
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.4.9
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
fast: false
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 4 AUTHORS: PMID:12937168,PMID:8218174 NOTES:NCD
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/6.3.4.3
product: MODEL1310110002#
is: SBO:0000176
reactant: MODEL1310110002#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_648f2254_2a2f_4785_8d9f_2d9077c45be5
has only substance units: false
is encoded by: hsa:223
initial concentration: NaN
type: Species
constant: false
name: ALDH9A1
is: P49189
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaM dhap m
type: Species
initial amount: NaN
is: HMDB01473
has only substance units: false
boundary condition: false
name: Dihydroxyacetone phosphate
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3411
is: C00111
initial concentration: 1.0
constant: false

metaM oh1 e
is: SBO:0000247
constant: false
is: HMDB01039
has only substance units: false
is: C01328
boundary condition: false
initial amount: NaN
name: hydroxide ion
initial concentration: 1.0
notes: FORMULA: HO CHARGE: -1
type: Species

metaR ATPH2e
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.6.1.5
is version of: http://identifiers.org/ec-code/3.6.1.6
kinetic law: MODEL1310110002#
is described by: ECO:0000269
name: ATP diphosphohydrolase
fast: false
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
is: SBO:0000176
reversible: false
modifier: MODEL1310110002#

metaR Q10H2e
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 3 AUTHORS: PMID: 17482886. NOTES:plasma concentration of ubiquinol indicates healthy state of an individual.
reactant: MODEL1310110002#
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110002#
name: transport of ubiquinol into lymph
is: SBO:0000185
reversible: true
product: MODEL1310110002#

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaR PPNCL3
modifier: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
notes: GENE_ASSOCIATION: (79717.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110002#
name: phosphopantothenate-cysteine ligase
is version of: http://identifiers.org/ec-code/6.3.2.5
fast: false
reactant: MODEL1310110002#
type: Reaction
product: MODEL1310110002#

metaR P4507A1r
type: Reaction
notes: GENE_ASSOCIATION: (1581.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.14.13.17 Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/1.14.13.17
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
reversible: false
product: MODEL1310110002#
name: cytochrome P450, family 7, subfamily A, polypeptide 1
is: SBO:0000176
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_e7931e72_d3ec_439d_8655_f7799e5ce439
has part: Q8TF08
initial concentration: NaN
has part: Q7Z4L0
has part: Q96KJ9
is encoded by: hsa:1351
initial amount: NaN
is encoded by: hsa:1345
is encoded by: hsa:4514
has part: H0UI06
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:1337
is encoded by: hsa:1347
is encoded by: hsa:9167
is encoded by: hsa:1339
is encoded by: hsa:4512
constant: false
has part: P12074
has part: P09669
is encoded by: hsa:1346
is encoded by: hsa:84701
has part: Q53YB7
has only substance units: false
has part: P14854
has part: P24310
has part: Q7GXZ8
has part: P00414
is encoded by: hsa:1350
has part: Q6FGA0
has part: Q7GXY8
type: Species
is encoded by: hsa:170712
boundary condition: true
has part: P13073
is encoded by: hsa:125965
is encoded by: hsa:1327
is encoded by: hsa:341947
is encoded by: hsa:9377
is: SBO:0000297
is encoded by: hsa:1340
has part: P20674
has part: Q53XN1
is encoded by: hsa:4513
has part: P24311
has part: Q02221
has part: Q6YFQ2
is encoded by: hsa:1349
has part: P15954
is encoded by: hsa:1329

http://identifiers.org/biomodels.db/MODEL1310110002#_8e1fcc15_70ec_4a83_9b8e_c39cfac3d5fb
initial concentration: NaN
name: GALNT1
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q10472
is encoded by: hsa:2589
is: SBO:0000252
constant: false
type: Species

metaM chlstol r
name: 5alpha-cholesta-7,24-dien-3beta-ol
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
is: SBO:0000247
is: CHEBI:16290
has only substance units: false
initial amount: NaN
is: HMDB06842
constant: false
type: Species
initial concentration: 1.0

metaR MAGt
reversible: true
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:10344773 NOTES:
reactant: MODEL1310110002#
name: monoacylglycerol 2 transport
is: SBO:0000185
type: Reaction
fast: false

metaM 3mop m
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-3-4(2)5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC01123 EHMN_ABBREVIATION: C00671
type: Species
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00491
is: CHEBI:28654
name: 3-methyl-2-oxopentanoate
has only substance units: false
initial amount: NaN

metaM pe hs m
boundary condition: false
name: phosphatidylethanolamine
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:16038
initial amount: NaN
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02002 EHMN_ABBREVIATION: C00350
initial concentration: 1.0
constant: false

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaR EX nrpphr LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Norepinephrine exchange
type: Reaction

metaM pi x
name: hydrogenphosphate
has only substance units: false
is: CHEBI:43474
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: HMDB00973
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_fefe4728_1cd7_4220_9060_c25a8cdd1fb3
constant: false
is: SBO:0000252
has only substance units: false
is: P43353
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: ALDH3B1
is encoded by: hsa:221
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_983558f7_9907_45dd_bf51_797379133a6b
initial amount: NaN
initial concentration: NaN
is: Q3I5F7
has only substance units: false
type: Species
constant: false
is: SBO:0000252
boundary condition: true
name: ACOT6
is encoded by: hsa:641372

metaM pap g
is: HMDB00061
is: CHEBI:58343
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
boundary condition: false
name: adenosine 3',5'-bismonophosphate(4-)
constant: false
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054

metaM 4ppcys m
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial amount: NaN
is: CHEBI:59458
boundary condition: false
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
is: HMDB01117
constant: false

metaM HC01115 c
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: NeuNGc
boundary condition: false
constant: false
is: CHEBI:29025
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_6f997cb8_dd47_46e2_8d56_ea38a4aaadfd
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110002#_048a132c_c82f_4762_a991_7949128362c4
constant: false
name: HLCS
is encoded by: hsa:3141
is: P50747
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_5170bb06_4d21_4c38_b285_0ce0e87aa5ab
is: SBO:0000252
initial amount: NaN
name: _AI697028_1_e
is encoded by: hsa:AI697028
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true

metaM fum m
is: CHEBI:29806
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: C00122
is: HMDB00134
notes: FORMULA: C4H2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00120 EHMN_ABBREVIATION: C00122
type: Species
constant: false
name: Fumarate
boundary condition: false

metaR NCAMUP
product: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
reversible: false
fast: false
is: SBO:0000185
name: Nicotinamide acid uptake
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
kinetic law: MODEL1310110002#

metaM lnlccrn m
initial amount: NaN
has only substance units: false
name: Linoleyl carnitine
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9-,13-12-/t23-/m1/s1
initial concentration: 1.0
type: Species
constant: false
is: SBO:0000247
is: HMDB06469
boundary condition: false

metaM dopa c
is: HMDB00073
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
has only substance units: false
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:59905
name: dopaminium(1+)
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_5e6623c4_0e6f_44bc_b7c1_270c88b0d0b4
name: NDUFA11
type: Species
is encoded by: hsa:126328
constant: false
initial amount: NaN
boundary condition: true
is: C9JT23
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR GTHPm
is: SBO:0000176
reactant: MODEL1310110002#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.11.1.12
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.11.1.15
name: glutathione peroxidase, mitochondria
fast: false
modifier: MODEL1310110002#
reversible: true
type: Reaction
product: MODEL1310110002#

metaR H2O2t
is: SBO:0000185
reversible: true
product: MODEL1310110002#
name: hydrogen peroxide transport via diffusion
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
reactant: MODEL1310110002#

metaR r0267
type: Reaction
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is: SBO:0000176
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
modifier: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.5.1.9
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_a83df90c_9037_4efe_941d_07e7427d789e
is encoded by: hsa:1345
has only substance units: false
initial concentration: NaN
name: COX6C
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P09669
constant: false
type: Species

metaM dhf c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57451
is: SBO:0000247
name: 7,8-Dihydrofolate
is: C00415
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
constant: false
has only substance units: false
boundary condition: false
type: Species
is: HMDB01056

http://identifiers.org/biomodels.db/MODEL1310110002#_54cbb040_ebf4_409e_b81b_bf4e6820c315
initial concentration: NaN
type: Species
is: SBO:0000252
name: _AI934540_1_c
constant: false
is encoded by: hsa:AI934540
boundary condition: true
has only substance units: false
initial amount: NaN

metaM dolmanp U c
is: CHEBI:15809
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
name: Dolichyl phosphate D-mannose, human uterine homolog
has only substance units: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial concentration: 1.0
boundary condition: false

metaR CSNATr
type: Reaction
is described by: ECO:0000000
name: carnitine O-acetyltransferase
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF
is: SBO:0000176
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_c5fca3f4_7340_4bf4_bbc1_211bc7adb186
is: Q9BZ23
initial amount: NaN
type: Species
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:80025
name: PANK2
constant: false

metaR RE3004M
is: SBO:0000176
type: Reaction
reversible: true
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.16
fast: false
is described by: ECO:0000000
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: RE3004
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_491db35a_5a4c_454e_8602_e277198cb409
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q9NSW9
is encoded by: hsa:6553
constant: false
is: SBO:0000252
name: SLC9A5
initial concentration: NaN
type: Species

metaR r2521
is described by: ECO:0000000
product: MODEL1310110002#
is: SBO:0000185
kinetic law: MODEL1310110002#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
reactant: MODEL1310110002#
reversible: true
name: Utilized transport

metaR RE0830N
reversible: true
is: SBO:0000176
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.96
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
product: MODEL1310110002#
is described by: ECO:0000000
fast: false
name: RE0830

metaM sphmyln hs c
boundary condition: false
name: sphmyln_hs[c]
initial amount: NaN
is: SBO:0000247
constant: false
is: HMDB00156
type: Species
has only substance units: false
is: CHEBI:15589
notes: FORMULA: CHARGE: 0
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_7413dc65_85c2_449c_91bf_a00a2c7e8ed4
is encoded by: hsa:594
constant: false
name: BCKDHB
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
type: Species
is: P21953

metaM oh1 c
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB01039
boundary condition: false
is: C01328
name: hydroxide ion
initial amount: NaN
notes: FORMULA: HO CHARGE: -1
initial concentration: 1.0
type: Species

metaR UDPDOLPT U
fast: false
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.117
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
reversible: false
name: UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase (uterus)
notes: GENE_ASSOCIATION: (29880.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.117 Confidence Level: 0 AUTHORS: PMID:10359825,PMID:8280060 NOTES:NCD
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#

metaR RDH3a
fast: false
kinetic law: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.105
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.300
is: SBO:0000176
is described by: ECO:0000269
name: retinol dehydrogenase (11-cis,NADPH)
product: MODEL1310110002#
modifier: MODEL1310110002#
reversible: true

metaM dcyt c
type: Species
boundary condition: false
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
initial amount: NaN
has only substance units: false
is: HMDB00014
constant: false
name: Deoxycytidine
is: SBO:0000247
is: CHEBI:15698
is: C00881
initial concentration: 1.0

metaR r0268
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.1
is described by: ECO:0000000
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
type: Reaction
product: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
reversible: true
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.1.3.2

metaR URATEt
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: urate export from cytosol
reversible: false
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
product: MODEL1310110002#

metaR r2520
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110002#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
type: Reaction
product: MODEL1310110002#

metaR r1147
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#

metaM ala B e
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
name: beta-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
is: CHEBI:16958
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: HMDB00056

http://identifiers.org/biomodels.db/MODEL1310110002#_140ccc17_0254_4c77_a0ea_f17d88e253af
initial concentration: NaN
is encoded by: hsa:3028
type: Species
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is: Q99714
name: HSD17B10
initial amount: NaN

metaM core3 g
constant: false
is: SBO:0000247
initial concentration: 1.0
name: Core 3
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C16H27N2O10X CHARGE: 0
is: CHEBI:16250

metaR OROTGLUt
reversible: true
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000134
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
name: OROTGLUt

metaR SPHS1Pte
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10751414 NOTES:unknown mechanism, however sphs1p is known to have intracellular and extracellular activity and signal transduction functions (PMID: 10751414). NJ
is described by: ECO:0000000
product: MODEL1310110002#
fast: false
name: sphingosine-1-phosphate transport
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_ec30f36e_56ff_4acd_b698_c71c0eafe25d
constant: false
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: NDUFA12
is encoded by: hsa:55967
boundary condition: true
is: SBO:0000252
is: F8VQS7

metaR ALADGLNexR
product: MODEL1310110002#
is described by: ECO:0000304
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110002#
fast: false
reversible: true
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110002#
name: L-alanine/glutamine reversible exchange

metaR NH4tp
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
product: MODEL1310110002#
name: ammonia peroxisomal transport
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false

metaR THP2Ctp
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
reactant: MODEL1310110002#
type: Reaction
fast: false

metaR r0660
fast: false
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
reversible: true
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.5.1.2

http://identifiers.org/biomodels.db/MODEL1310110002#_5748af73_0a67_4917_9042_c97e83c15b9a
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:6565
is: Q16348
has only substance units: false
name: SLC15A2
boundary condition: true

metaM dopa e
has only substance units: false
boundary condition: false
notes: FORMULA: C8H12NO2 CHARGE: 1 INCHI: InChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2/p+1 HEPATONET_1.0_ABBREVIATION: HC01175 EHMN_ABBREVIATION: C03758
name: dopaminium(1+)
is: CHEBI:59905
initial amount: NaN
constant: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00073

http://identifiers.org/biomodels.db/MODEL1310110002#_6c2c7c08_73f8_4256_98f6_bd8d282272e3
is encoded by: hsa:4712
name: NDUFB6
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
is: O95139
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_2b27b500_521a_47a5_ae51_d5dd8d96c062
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: _T83654_1_c
is encoded by: hsa:T83654
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaM HC02180 c
is: CHEBI:28728
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
boundary condition: false
initial amount: NaN
name: thromboxane-b2
constant: false
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR FAOXC101C102m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_aa82773f_4a41_4782_84ce_57b04a66d4bb
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: COX7A2
type: Species
is encoded by: hsa:1347
initial amount: NaN
is: H0UI06

http://identifiers.org/biomodels.db/MODEL1310110002#_38d272c4_1a89_4df1_b427_4398da724781
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1798
name: DPAGT1
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_fa156653_1084_4cb7_8b8d_95d6095e49ab
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:127
type: Species
boundary condition: true
name: ADH4
has only substance units: false
is: P08319
constant: false

metaM s2l2n2m2m l
is: HMDB01356
is: CHEBI:57312
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
name: de-Fuc form of PA6 (w/o peptide linkage)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C84H136N6O62 CHARGE: -2
has only substance units: false

metaM pail34p hs c
is: CHEBI:57658
boundary condition: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
type: Species
constant: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate(5-)
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR r1568
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110002#
fast: false
is: SBO:0000185
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110002#_d8f2d937_5ad7_4ec5_aa4b_27d2fed8b280
is: GO:0005777
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: peroxisome
type: Compartment

metaR EX urate LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Urate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_df22fee4_0bb3_46f8_ba87_ef44d182853a
is: SBO:0000252
initial concentration: NaN
name: FAH
boundary condition: true
is encoded by: hsa:2184
has only substance units: false
is: P16930
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_6235faa6_578b_4a0c_92bb_e14662e5f35b
has only substance units: false
name: FUT1
initial concentration: NaN
is: Q6IZA2
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:2523

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_c
is: CHEBI:18287
constant: false
boundary condition: false
initial amount: NaN
is: HMDB00174
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0

metaM ala B c
initial amount: NaN
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c4-2-1-3(5)6/h1-2,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00100
name: beta-alanine
constant: false
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:16958
is: HMDB00056

metaM q10h2 c
initial amount: NaN
type: Species
is: HMDB13111
initial concentration: 1.0
constant: false
is: SBO:0000247
name: Ubiquinol-10
has only substance units: false
is: http://identifiers.org/pubchem.compound/6504740
boundary condition: false
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00324

http://identifiers.org/biomodels.db/MODEL1310110002#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEtg
is described by: ECO:0000000
fast: false
product: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is: SBO:0000185
name: blood group intracellular transport
reactant: MODEL1310110002#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_7e76deed_ed62_489b_9b8f_d5d87776a019
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: HMGCS1
is encoded by: hsa:3157
is: SBO:0000252
has only substance units: false
is: Q01581
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_668fa1c0_5011_46e0_9429_7086a4394d7c
name: ENTPD8
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:377841
type: Species
initial amount: NaN
is: SBO:0000252
is: Q5MY95

metaM gal14acglcgalgluside hs g
initial amount: NaN
is: CHEBI:17103
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
name: Lactoneotetraosylceramide
is: SBO:0000247
has only substance units: false

metaR NACHEX27ly
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
reversible: false
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110002#
is described by: ECO:0000269
is: SBO:0000176

metaR r1569
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#

metaM ksi pre36 g
is: CHEBI:28067
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 36
notes: FORMULA: C247H394N17O210S11X CHARGE: -12

metaM dump m
constant: false
is: SBO:0000247
is: CHEBI:246422
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
name: dUMP(2-)
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
initial concentration: 1.0
is: HMDB01409

metaM HC00591 m
is: CHEBI:16769
type: Species
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
is: SBO:0000247
has only substance units: false
name: 2-oxoglutaramate
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM ha deg1 l
notes: FORMULA: C22H33N2O16 CHARGE: -1
name: hyaluronan degradation product 1
initial amount: NaN
is: SBO:0000247
is: CHEBI:16336
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
boundary condition: false

metaM na1 c
is: SBO:0000247
is: CHEBI:4541
is: C01330
notes: FORMULA: Na CHARGE: 1
is: HMDB00588
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
name: Sodium

http://identifiers.org/biomodels.db/MODEL1310110002#_c1ad34e1_40e3_4ff1_8ced_9011d173a30e
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2348
constant: false
initial amount: NaN
name: FOLR1
type: Species
boundary condition: true

metaR CSND
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110002#
reactant: MODEL1310110002#
name: Cytosine deaminase
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
reversible: false

metaM HC02180 e
is: CHEBI:28728
initial amount: NaN
notes: FORMULA: C20H33O6 CHARGE: -1 INCHI: InChI=1S/C20H34O6/c1-2-3-6-9-15(21)12-13-18-16(17(22)14-20(25)26-18)10-7-4-5-8-11-19(23)24/h4,7,12-13,15-18,20-22,25H,2-3,5-6,8-11,14H2,1H3,(H,23,24)/b7-4-,13-12+/t15-,16-,17-,18+,20?/m0/s1 EHMN_ABBREVIATION: C05963
boundary condition: false
constant: false
is: SBO:0000247
name: thromboxane-b2
type: Species
initial concentration: 1.0
has only substance units: false

metaM m4mpdol U c
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:37633
initial concentration: 1.0
has only substance units: false
constant: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1

metaR r1921
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GLYC3Ptmc
reversible: true
kinetic law: MODEL1310110002#
fast: false
type: Reaction
name: glycerol-3-phopshate transport, cytoplasm
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: added during gap filling. No evidence found for such a reaction. NOTES:added during gap filling. No evidence found for such a reaction.
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110002#_0aab04be_aab0_4bc8_83cd_4cc01a04dd62
is: G3V5N0
type: Species
name: FUT8
constant: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:2530

http://identifiers.org/biomodels.db/MODEL1310110002#_a91022f9_4553_495f_9deb_f38df0382524
initial concentration: NaN
is encoded by: hsa:55349
is: Q8NE62
initial amount: NaN
constant: false
boundary condition: true
name: CHDH
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_0c3620e8_257d_448c_b39c_56b991dfa017
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: O43674
name: NDUFB5
type: Species
is encoded by: hsa:4711

http://identifiers.org/biomodels.db/MODEL1310110002#_d481c998_2793_498e_90a5_c0fb06ebd702
boundary condition: true
has only substance units: false
is encoded by: hsa:5211
constant: false
has part: Q7L2M7
initial concentration: NaN
name: PFKL:PFKP
initial amount: NaN
is: SBO:0000297
type: Species

metaR CYTK9n
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reversible: true
fast: false
name: cytidylate kinase (CMP,dCTP),nuclear
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_cd3690a8_91d2_48a6_9515_4383e54d317b
name: SDHA:SDHB:SDHC:SDHD
has part: P21912
has only substance units: false
initial concentration: NaN
has part: O14521
is encoded by: hsa:6391
has part: Q99643
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:6389
has part: P31040
is encoded by: hsa:6390
is: SBO:0000297
is encoded by: hsa:6392

metaM ksii core2 deg1 l
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
initial amount: NaN
is: CHEBI:57737
type: Species
name: keratan sulfate II (core 2-linked), degradation product 1
boundary condition: false
constant: false
is: HMDB00868

metaM HC01397 m
initial concentration: 1.0
type: Species
is: CHEBI:27402
initial amount: NaN
notes: FORMULA: C37H62N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-26,30-32,36,45,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/t25-,26+,30+,31+,32-,36+/m0/s1 EHMN_ABBREVIATION: C05258
is: SBO:0000247
has only substance units: false
boundary condition: false
name: (S)-3-Hydroxyhexadecanoyl-CoA
constant: false

metaR GLCAASE7ly
name: beta-glucuronidase, lysosomal
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.31
fast: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is described by: ECO:0000000
modifier: MODEL1310110002#

metaM biocyt c
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7886
name: Biocytin
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB03134
type: Species
is: C05552

metaM dump n
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: HMDB01409
name: dUMP(2-)
notes: FORMULA: C9H11N2O8P CHARGE: -2 INCHI: InChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00309 EHMN_ABBREVIATION: C00365
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:246422

metaR r0994
reversible: true
product: MODEL1310110002#
name: Facilitated diffusion
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#

metaR r2308
reversible: true
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110002#
fast: false
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

metaM bhb m
is: SBO:0000247
type: Species
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: HMDB00011
is: CHEBI:10983
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: (R)-3-hydroxybutyrate
has only substance units: false

metaM utp n
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: CHEBI:46398
constant: false
initial amount: NaN
name: UTP(4-)
type: Species
is: SBO:0000247
is: HMDB00285

http://identifiers.org/biomodels.db/MODEL1310110002#_ac1a790f_0def_4166_bfef_847bea052556
initial concentration: NaN
name: SLC7A5
is encoded by: hsa:8140
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is: Q8IV97
boundary condition: true

metaM q10h2 e
is: http://identifiers.org/pubchem.compound/6504740
name: Ubiquinol-10
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C59H92O4 CHARGE: 0 INCHI: InChI=1/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
boundary condition: false
is: HMDB13111
type: Species
constant: false
is: SBO:0000247
initial amount: NaN

metaM 3hibutcoa m
constant: false
is: CHEBI:28259
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: (S)-3-Hydroxyisobutyryl-CoA
has only substance units: false
is: HMDB01052
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
is: SBO:0000247

metaR GLNtN1
reversible: true
name: Glutamine transport (Na, H coupled)
type: Reaction
reactant: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
is described by: ECO:0000269
modifier: MODEL1310110002#
fast: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#

metaR PECDCHe
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of pectins with deoxycholic acid in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR LNLNCGt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
type: Reaction
name: fatty acid transport via diffusion
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000185
reversible: true

metaM na1 e
type: Species
name: Sodium
is: CHEBI:4541
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: Na CHARGE: 1
is: C01330
is: HMDB00588
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_a62b1e80_afd9_4c0a_8029_0be4e4199b85
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:6487
boundary condition: true
name: ST3GAL3
type: Species
is: Q96L53

metaR GLYt7 211 r
name: glycine reversible transport via sodium and chloride symport (2:1:1)
reactant: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000185
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110002#
fast: false
type: Reaction

metaM glx c
constant: false
name: glyoxylate
initial amount: NaN
is: CHEBI:36655
is: SBO:0000247
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
initial concentration: 1.0
is: HMDB00119
has only substance units: false
boundary condition: false
type: Species

metaR r2309
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is: SBO:0000185
reactant: MODEL1310110002#
fast: false

metaM hexdicoa x
constant: false
initial amount: NaN
notes: FORMULA: C37H59N7O19P3S CHARGE: -5
name: hexadecanedioylcoa
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110002#_a4a15310_99e8_40fb_9f3f_78ff8780dc21
is: O75912
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: DGKI
type: Species
boundary condition: true
is encoded by: hsa:9162
is: SBO:0000252

metaM fpram c
notes: FORMULA: C8H15N3O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01329 EHMN_ABBREVIATION: C04640
constant: false
type: Species
has only substance units: false
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58478
initial amount: NaN
is: HMDB06211
boundary condition: false
is: C04640

metaR ECOAH1m
is described by: ECO:0000304
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.18
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) SUBSYSTEM: Tryptophan metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:7558027 NOTES:SAB for mito
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
type: Reaction

metaM CE1926 e
initial amount: NaN
type: Species
name: gama-carboxyethyl-hydroxychroman
notes: FORMULA: C15H19O4 CHARGE: -1 INCHI: InChI=1/C15H20O4/c1-9-10(2)14-11(8-12(9)16)4-6-15(3,19-14)7-5-13(17)18/h8,16H,4-7H2,1-3H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1926
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00127
is: CHEBI:15748
is: SBO:0000247
boundary condition: false

metaM m5masnC g
initial amount: NaN
notes: FORMULA: C52H87N2O40X CHARGE: 0
boundary condition: false
is: SBO:0000247
is: CHEBI:58282
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
type: Species
constant: false
initial concentration: 1.0
is: HMDB00968

http://identifiers.org/biomodels.db/MODEL1310110002#_746f4136_ecda_4dcc_ac6c_5b83e9274365
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P07327
constant: false
name: ADH1A
initial amount: NaN
is encoded by: hsa:124

metaR r2315
product: MODEL1310110002#
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110002#
fast: false
type: Reaction

metaR ORNt4m
reversible: true
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
modifier: MODEL1310110002#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110002#
name: ornithine mitochondrial transport exchange with citruline
is described by: ECO:0000269
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_d885e196_783e_4b2f_8b3b_5976df05053e
initial concentration: NaN
is: P23743
type: Species
is encoded by: hsa:1606
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
name: DGKA

metaR r1625
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
fast: false
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110002#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_e7a1ad86_fb13_4e36_b638_ab1a5a9d43ef
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5476
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is: P10619
name: CTSA

http://identifiers.org/biomodels.db/MODEL1310110002#_bca9214a_c0d6_47ba_855e_01767fc05b61
initial amount: NaN
is: O76062
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:7108
initial concentration: NaN
name: TM7SF2
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_c435dfd6_04d1_4575_b068_9cba23139b6f
is encoded by: hsa:30
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is: Q96CA6
boundary condition: true
has only substance units: false
type: Species
name: ACAA1

metaM adrncoa x
initial concentration: 1.0
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205480
constant: false
is: C16170
name: adrenyl coenzyme A
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
boundary condition: false

metaR URAt
modifier: MODEL1310110002#
name: uracil transport via facilated diffusion
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110002#
is: SBO:0000185
reactant: MODEL1310110002#

metaM idp n
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: SBO:0000247
is: CHEBI:58280
is: HMDB03335
boundary condition: false
name: IDP(3-)
constant: false
initial amount: NaN

metaR G5SADrm
is described by: ECO:0000000
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:spontaneous reaction NCD
fast: false
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
kinetic law: MODEL1310110002#

metaR ALDD2xm
type: Reaction
reactant: MODEL1310110002#
reversible: false
name: aldehyde dehydrogenase (acetylaldehyde, NAD), mitochondrial
notes: GENE_ASSOCIATION: (219.1) or (217.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:18983992,PMID:18983993,PMID:19382904,PMID:19382905 NOTES:NCD. For NAD
fast: false
modifier: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110002#

metaM dolglcp U c
initial amount: NaN
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog
type: Species
constant: false
is: CHEBI:15812

http://identifiers.org/biomodels.db/MODEL1310110002#_db5fbb9d_2cd2_48f8_922a_4fe83fa3682e
initial concentration: NaN
name: ADH1A:ADH1B
boundary condition: true
initial amount: NaN
constant: false
has part: P07327
type: Species
is encoded by: hsa:124
has only substance units: false
is: SBO:0000297

metaR r0549
type: Reaction
modifier: MODEL1310110002#
name: 4-aminobutanal:NAD+ 1-oxidoreductase; 4-aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups / beta-Alanine metabolism EC:1.2.1.3 EC:1.2.1.19
is: SBO:0000176
kinetic law: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA629629.1) or (AA854479.1) or (AI345944.1) or (AI378339.1) or (AI601100.1) or (AI631997.1) or (AI935189.1) or (124454.1) or (F23536.1) or (FLJ44968.1) or (H45672.1) or (H53099.1) or (3550.1) or (LOC727762.1) or (4694.1) or (4705.1) or (126328.1) or (55967.1) or (51079.1) or (4695.1) or (4696.1) or (4697.1) or (56901.1) or (4698.1) or (4700.1) or (4701.1) or (4702.1) or (4704.1) or (4706.1) or (4707.1) or (4716.1) or (54539.1) or (4708.1) or (4709.1) or (4710.1) or (4711.1) or (4712.1) or (4713.1) or (4714.1) or (4715.1) or (4717.1) or (4718.1) or (4719.1) or (4720.1) or (4722.1) or (4724.1) or (4725.1) or (4726.1) or (374291.1) or (4728.1) or (4723.1) or (4729.1) or (4731.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:2925663,PMID:8155713,PMID:8269919,PMID:8786138,PMID:9417993 NOTES:
is version of: http://identifiers.org/ec-code/1.6.5.3
product: MODEL1310110002#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.6.99.3
is version of: http://identifiers.org/ec-code/6.1.1.17
reactant: MODEL1310110002#

metaM 3hexdtricoa m
has only substance units: false
type: Species
initial amount: NaN
is: HMDB02288
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
name: 3,7,10-hexadecatrienoylcoa
boundary condition: false
constant: false
is: SBO:0000247

metaR EX ps hs LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: phosphatidylserine (homo sapiens) exchange
type: Reaction

metaR r0653
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10706581,PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110002#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: false
name: myristoyl-CoA:acetylCoA C-myristoyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#

metaR r2519
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
name: Utilized transport
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185

metaM utp c
initial concentration: 1.0
is: HMDB00285
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
is: C00075
is: CHEBI:46398
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
name: UTP
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_86794843_92ae_47c7_a731_29a9e4729159
has only substance units: false
boundary condition: true
name: NDUFS6
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is: Q6IBC4
is encoded by: hsa:4726
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_ea217072_e755_4617_b2de_966fd8a96a0c
has only substance units: false
constant: false
is encoded by: hsa:6647
boundary condition: true
name: SOD1
initial amount: NaN
type: Species
is: P00441
is: SBO:0000252
initial concentration: NaN

metaM HC01610 e
name: CoproporphyrinogenI
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:28607
type: Species
notes: FORMULA: C36H40N4O8 CHARGE: -4 INCHI: InChI=1S/C36H44N4O8/c1-17-21(5-9-33(41)42)29-14-26-19(3)23(7-11-35(45)46)31(39-26)16-28-20(4)24(8-12-36(47)48)32(40-28)15-27-18(2)22(6-10-34(43)44)30(38-27)13-25(17)37-29/h37-40H,5-16H2,1-4H3,(H,41,42)(H,43,44)(H,45,46)(H,47,48) EHMN_ABBREVIATION: C05768
constant: false
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_01a8a2c8_254e_40a7_ae57_59f8512eb808
boundary condition: true
initial concentration: NaN
constant: false
name: EGFL8
initial amount: NaN
is: SBO:0000252
is: Q99944
is encoded by: hsa:80864
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_2c844d2a_2398_4851_8ad3_3dcc9aed9d86
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:64841
name: GNPNAT1
is: SBO:0000252
is: Q96EK6
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_4b3a9b2d_ac01_4543_9f53_4fc9831de0b5
initial amount: NaN
is encoded by: hsa:AI972237
name: _AI972237_1_c
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
has only substance units: false

metaM dhap e
initial concentration: 1.0
boundary condition: false
name: glycerone phosphate(2-)
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h4H,1-2H2,(H2,6,7,8)/p-2 HEPATONET_1.0_ABBREVIATION: HC00109 EHMN_ABBREVIATION: C00111
has only substance units: false
is: CHEBI:57642
constant: false
is: HMDB01473

metaR r1626
modifier: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is: SBO:0000185
reversible: true

metaR FALDH
name: formaldehyde dehydrogenase
is described by: ECO:0000269
modifier: MODEL1310110002#
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
reactant: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.1 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
reversible: true

metaR PROSTGE2t
is: SBO:0000185
modifier: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
name: prostaglandin transport via bicarbonate countertransport
type: Reaction
reversible: true
is described by: ECO:0000269

metaR r1576
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110002#
fast: false
type: Reaction
kinetic law: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
reactant: MODEL1310110002#

metaR r0472
fast: false
product: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is described by: ECO:0000000
reactant: MODEL1310110002#

metaR r2314
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR GALtly
is: SBO:0000185
fast: false
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110002#
name: galactose efflux from lysosome
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
type: Reaction
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_7841dd74_6d72_45b6_a0a1_761386d62dba
is: Q9NYW8
name: RBAK
initial amount: NaN
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:57786
is: SBO:0000252
boundary condition: true
constant: false

metaM citr L m
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00904
initial concentration: 1.0
name: L-citrulline
type: Species
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
is: CHEBI:16349

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaR GCHOLAte
is: SBO:0000185
name: bile acid intracellular transport
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
fast: false
product: MODEL1310110002#
is described by: ECO:0000000

metaR r2317
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110002#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
fast: false
is: SBO:0000185

metaR GCC2cm
is version of: http://identifiers.org/ec-code/1.4.4.2
kinetic law: MODEL1310110002#
fast: false
name: glycine-cleavage complex (lipoamide), mitochondrial
type: Reaction
reactant: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.8.1.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.10
is described by: ECO:0000269
modifier: MODEL1310110002#

metaR DCSPTN1COAtx
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
name: fatty acid intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ

http://identifiers.org/biomodels.db/MODEL1310110002#_e2c2f182_72ea_47aa_bf2c_a2dae05a23fc
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:160728
has only substance units: false
name: SLC5A8
boundary condition: true
is: Q8N695

metaR HSD17B8r
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.62
notes: GENE_ASSOCIATION: (3294.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.62 Confidence Level: 4 AUTHORS: PMID:8099587 NOTES:microsomal NAD as cofactor HSD type 2 recheck/confirm comparmentalization - type 1: cytosol, types 2,3: microsomes NJ
modifier: MODEL1310110002#
product: MODEL1310110002#
name: 17-beta-hydroxysteroid dehydrogenase
reversible: false

metaR r1627
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaM ksi pre6 g
initial concentration: 1.0
is: C00130
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 6
is: SBO:0000247
type: Species
is: CHEBI:58053
notes: FORMULA: C107H174N7O80SX CHARGE: -2
constant: false
initial amount: NaN
has only substance units: false
boundary condition: false

metaM alpam m
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C9H21N2OS2 CHARGE: 1 INCHI: InChI=1/C9H20N2OS2/c10-7-14-6-5-8(13)3-1-2-4-9(11)12/h8,13H,1-7,10H2,(H2,11,12)
name: S-aminomethyldihydrolipoamide
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
is: HMDB06239

metaR r1579
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaM btcoa m
constant: false
initial amount: NaN
name: Butanoyl-CoA
type: Species
is: CHEBI:57371
is: SBO:0000247
has only substance units: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
initial concentration: 1.0
is: C00136
is: HMDB01088
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_92f3cf8e_7757_4fec_a82e_04df96e6d584
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AL525798
name: _AL525798_1_c
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false

metaR GBSIDEte
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110002#
reversible: true
name: globoside transport
is: SBO:0000185
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - The goal of this transporter is to get globoside to the EC plasma membrane NJ

http://identifiers.org/biomodels.db/MODEL1310110002#_6a34d2e7_0be8_4a45_8419_978a71862d7f
initial amount: NaN
is: E7ET32
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: GALT
type: Species
boundary condition: true
constant: false
is encoded by: hsa:2592

http://identifiers.org/biomodels.db/MODEL1310110002#_bb93c6f0_db47_4033_b0d6_05a006b206ee
constant: false
name: COX7B
type: Species
initial amount: NaN
is: P24311
initial concentration: NaN
has only substance units: false
is encoded by: hsa:1349
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_da3015e3_2982_4b2e_b97d_ee09d68bd649
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2678
has only substance units: false
boundary condition: true
type: Species
name: GGT1
initial concentration: NaN
is: P19440
constant: false

metaR r0879
product: MODEL1310110002#
is described by: ECO:0000000
name: TCDB:2.A.29.2.4 TCDB:2.A.29.16.1
is: SBO:0000185
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11287335,PMID:11327718 NOTES:
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110002#_ffff3497_61b2_4b48_8b34_2b398f8419b6
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: SDHC
is: Q99643
is: SBO:0000252
is encoded by: hsa:6391
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_metaR_ACGALFUCGALACGALFUC12GAL14ACGLCGALGLUSIDEte
is described by: ECO:0000000
name: blood group intracellular transport
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_546177af_41f3_40c1_9f7b_4cb068e18f66
is encoded by: hsa:51292
type: Species
name: GMPR2
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is: Q86T14
boundary condition: true
has only substance units: false

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

metaR r2316
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110002#
fast: false
product: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_d5e0d0a2_c56d_4f4e_97dd_d594cb33b618
is encoded by: hsa:6480
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is: B2R513
boundary condition: true
name: ST6GAL1

metaR GHMT2rm
name: glycine hydroxymethyltransferase, reversible, mitochondrial
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.1.2.1
product: MODEL1310110002#
is described by: ECO:0000269
modifier: MODEL1310110002#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110002#_289cb6e9_0122_4e8c_97bc_a7a35c797a8b
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110002#_2e74b9f8_8329_405b_8788_31dd1493854e
has only substance units: false
name: SPTLC2
is: O15270
is encoded by: hsa:9517
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true

metaM spc hs e
has only substance units: false
is: http://identifiers.org/pubchem.compound/5311445
initial concentration: 1.0
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
boundary condition: false
initial amount: NaN
name: sphingosylphosphorylcholine
constant: false
is: SBO:0000247
type: Species

metaR r1628
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_b79340bc_cc6b_4556_bd02_1c9645a32455
type: Species
name: SDHB
initial amount: NaN
is encoded by: hsa:6390
is: SBO:0000252
has only substance units: false
is: P21912
boundary condition: true
initial concentration: NaN
constant: false

metaM s2l2fn2m2masn g
has only substance units: false
initial concentration: 1.0
is: CHEBI:57737
initial amount: NaN
is: HMDB00868
boundary condition: false
name: PA6
is: SBO:0000247
type: Species
notes: FORMULA: C90H145N6O65X CHARGE: -2
constant: false

metaR r1578
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction

metaM 5tedtricoa m
name: 5,8,11-tetradecatrienoylcoa
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
type: Species
is: HMDB02288

metaR RE1573M
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
name: RE1573
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is described by: ECO:0000000
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.3.3.8

http://identifiers.org/biomodels.db/MODEL1310110002#_cb9906f8_53f7_4c2d_9276_e81aa0224152
is: SBO:0000252
type: Species
is encoded by: hsa:BG035985
has only substance units: false
boundary condition: true
name: _BG035985_1_c
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_667fdbbc_3f38_40f0_85d0_2ddadaf32333
initial concentration: NaN
is: P08237
boundary condition: true
initial amount: NaN
has only substance units: false
name: PFKM
is encoded by: hsa:5213
constant: false
is: SBO:0000252
type: Species

metaM s7p c
name: Sedoheptulose 7-phosphate
initial concentration: 1.0
has only substance units: false
type: Species
is: CHEBI:57483
is: C05382
is: HMDB01068
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaR r0474
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
reversible: true
fast: false
is described by: ECO:0000000
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1

http://identifiers.org/biomodels.db/MODEL1310110002#_92aa835b_cfce_420a_a618_569265e18f47
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1743
name: DLST
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is: P36957

metaM mi1345p c
is: HMDB01059
boundary condition: false
notes: FORMULA: C6H8O18P4 CHARGE: -8 INCHI: InChI=1S/C6H16O18P4/c7-1-3(21-25(9,10)11)2(8)5(23-27(15,16)17)6(24-28(18,19)20)4(1)22-26(12,13)14/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/p-8/t1-,2-,3-,4+,5-,6-/m0/s1 EHMN_ABBREVIATION: C01272
constant: false
is: CHEBI:57895
is: SBO:0000247
name: 1D-myo-inositol 1,3,4,5-tetrakisphosphate(8-)
has only substance units: false
type: Species
initial concentration: 1.0
initial amount: NaN

metaR r0655
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 0 AUTHORS: PMID:3597357,PMID:9214289 NOTES:
name: 3-Methylbutanoyl-CoA:(acceptor) 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.10
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
reversible: true

metaR DM T antigen g
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR PYK
modifier: MODEL1310110002#
name: pyruvate kinase
reactant: MODEL1310110002#
is described by: ECO:0000134
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
fast: false

metaR NACASPAH
fast: false
is: SBO:0000176
modifier: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (443.1) or (91703.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.15 Confidence Level: 4 AUTHORS: PMID:8252036 NOTES:SAB
reversible: false
kinetic law: MODEL1310110002#
name: N-Acetyl-L-aspartate amidohydrolase
is version of: http://identifiers.org/ec-code/3.5.1.15
product: MODEL1310110002#
is described by: ECO:0000269
type: Reaction

metaR TDCHOLAte
product: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
reversible: true
is described by: ECO:0000000
name: bile acid intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110002#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_b1015c36_d557_49fd_9d92_56e136d95753
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
is encoded by: hsa:11343
has only substance units: false
name: MGLL
is: Q99685
initial amount: NaN

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR r1629
type: Reaction
kinetic law: MODEL1310110002#
reversible: true
is: SBO:0000185
reactant: MODEL1310110002#
product: MODEL1310110002#
fast: false
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM HC02149 m
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1S/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: SBO:0000247
has only substance units: false
name: O-Propanoylcarnitine
is: CHEBI:28867
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_68c56729_b563_4372_b040_93208189f451
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
name: _F23536_1_m
is encoded by: hsa:F23536
initial amount: NaN
is: SBO:0000252
type: Species

metaR r0650
fast: false
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
product: MODEL1310110002#
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (60490.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
is version of: http://identifiers.org/ec-code/4.1.1.36
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_c0674145_0b60_4634_b39c_6c89d8b6e669
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
name: ALG3
has only substance units: false
is encoded by: hsa:10195
initial concentration: NaN
constant: false

metaR r2514
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
fast: false
reactant: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110002#
reversible: true
type: Reaction
name: Utilized transport

metaM HC00822 e
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:28681
name: Chitobiose
type: Species
notes: FORMULA: C16H28N2O11 CHARGE: 0 INCHI: InChI=1S/C16H28N2O11/c1-5(21)17-9-13(25)14(8(4-20)27-15(9)26)29-16-10(18-6(2)22)12(24)11(23)7(3-19)28-16/h7-16,19-20,23-26H,3-4H2,1-2H3,(H,17,21)(H,18,22)/t7-,8-,9-,10-,11-,12-,13-,14-,15?,16+/m1/s1 EHMN_ABBREVIATION: C01674

http://identifiers.org/biomodels.db/MODEL1310110002#_ff6574e0_2883_4eed_a3d1_5b98a7ad629e
boundary condition: true
is encoded by: hsa:760
initial concentration: NaN
constant: false
type: Species
name: CA2
has only substance units: false
is: P00918
initial amount: NaN
is: SBO:0000252

metaR r2311
kinetic law: MODEL1310110002#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110002#
fast: false
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is described by: ECO:0000000
product: MODEL1310110002#

metaR S26Tg
modifier: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
name: beta-galactoside alpha-2,6-sialyltransferase
reversible: false
kinetic law: MODEL1310110002#
is: SBO:0000176
reactant: MODEL1310110002#
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (6480.1) or (6480.3) or (6480.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.99.1 Confidence Level: 0 AUTHORS: PMID:8027041 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.99.1

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR r0475
type: Reaction
reversible: true
kinetic law: MODEL1310110002#
is: SBO:0000176
reactant: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000000
fast: false
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:

metaR r1573
type: Reaction
kinetic law: MODEL1310110002#
product: MODEL1310110002#
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110002#
reversible: true

metaM leuktrE4 c
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57462
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
boundary condition: false
type: Species
initial amount: NaN
is: HMDB02200
constant: false
name: leukotriene E4(1-)

metaR EX prostgh2 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin H2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_6ce77619_9b5c_4836_bc09_3af1e1be161d
has only substance units: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
name: NDUFA2
is: O43678
type: Species
is encoded by: hsa:4695

http://identifiers.org/biomodels.db/MODEL1310110002#_d2289e30_1d01_4ad6_a0ca_d968bb6f37e5
initial amount: NaN
is encoded by: hsa:1962
constant: false
name: EHHADH
is: Q9NY65
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_07744f0a_fee9_4091_8623_d31ef386ef1e
name: COX3
is encoded by: hsa:4514
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is: P00414

http://identifiers.org/biomodels.db/MODEL1310110002#_9a060d9e_d722_4ace_b54d_fef7b729f04a
boundary condition: true
constant: false
is encoded by: hsa:2222
name: FDFT1
type: Species
initial amount: NaN
is: SBO:0000252
is: P37268
has only substance units: false
initial concentration: NaN

metaR HSD3A2r
is described by: ECO:0000000
product: MODEL1310110002#
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
is version of: http://identifiers.org/ec-code/1.1.1.225
reactant: MODEL1310110002#
type: Reaction
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
fast: false
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_bcd0eeab_92f7_406c_b4f9_dc61f5331db4
name: ATP10A
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:57194
is: SBO:0000252
has only substance units: false
is: O60312

metaR PItg
product: MODEL1310110002#
reversible: false
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: phosphate transport, Golgi apparatus
kinetic law: MODEL1310110002#
fast: false

metaM ksii core4 pre6 g
has only substance units: false
notes: FORMULA: C69H111N6O51SX CHARGE: -2
is: SBO:0000247
boundary condition: false
type: Species
name: keratan sulfate II biosynthesis, precursor 6
initial amount: NaN
constant: false
is: CHEBI:28067
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_c85399ea_75f9_4032_b6c7_d4effb25d30f
has only substance units: false
boundary condition: true
is: SBO:0000252
name: _T83654_1_e
constant: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:T83654

metaM ser L m
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: L-serine
initial concentration: 1.0
is: HMDB00187
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
type: Species
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_32caa821_16c8_47e0_9478_a47b47882bd2
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
is: Q7GXY8
name: COX1
is encoded by: hsa:4512
initial concentration: NaN
has only substance units: false

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM succoa m
type: Species
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00093 EHMN_ABBREVIATION: C00091
is: SBO:0000247
is: CHEBI:57292
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: Succinyl-CoA
is: HMDB01022
constant: false
initial amount: NaN

metaR r2310
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110002#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185

metaR NDPK2n
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269
modifier: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_5e2772f8_7edc_4539_91e9_33a5358b9233
type: Species
is: SBO:0000252
is: P42126
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1632
name: ECI1
constant: false

metaM ksii core4 g
initial concentration: 1.0
is: CHEBI:57614
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
name: keratan sulfate II (core 4-linked)
constant: false
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00189
is: SBO:0000247

metaR G16MT U
is described by: ECO:0000000
reversible: false
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110002#
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
kinetic law: MODEL1310110002#
is: SBO:0000176
reactant: MODEL1310110002#

metaM s2l2fn2m2masn l
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
name: PA6
is: HMDB00174
is: CHEBI:18287
notes: FORMULA: C90H145N6O65X CHARGE: -2
type: Species
initial amount: NaN
is: SBO:0000247

metaR ITPtn
fast: false
is: SBO:0000185
reactant: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
name: ITP nuclear transport
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#

metaR DAGK hs
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.1.107 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: true
is version of: http://identifiers.org/ec-code/2.7.1.107
name: Diacylglycerol phosphate kinase (homo sapiens)
reactant: MODEL1310110002#
is: SBO:0000176
fast: false
type: Reaction
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000269
product: MODEL1310110002#

metaR r0652
is version of: http://identifiers.org/ec-code/1.5.1.2
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110002#
name: trans-Tetradec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
modifier: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_fcfd401d_1da7_47c2_ad55_20b1c16d4184
is: SBO:0000252
initial amount: NaN
is: P42765
boundary condition: true
is encoded by: hsa:10449
initial concentration: NaN
name: ACAA2
constant: false
type: Species
has only substance units: false

metaM HC01401 x
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27668
boundary condition: false
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
name: (S)-3-Hydroxydodecanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110002#_b1d8e80e_64c7_466a_833d_859a9f407382
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:218
is: SBO:0000252
is: P30838
boundary condition: true
name: ALDH3A1
constant: false
has only substance units: false

metaR r2200
reactant: MODEL1310110002#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
product: MODEL1310110002#
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000185
type: Reaction
reversible: true
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR r2313
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_1bd9a61f_1b53_49a3_8a42_2627a4a34378
is: O43252
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:9061
type: Species
initial amount: NaN
name: PAPSS1

http://identifiers.org/biomodels.db/MODEL1310110002#_84437a79_fb26_404a_b394_6aa330d5bd16
name: AICDA
has only substance units: false
boundary condition: true
is encoded by: hsa:57379
is: SBO:0000252
constant: false
is: Q546Y9
type: Species
initial concentration: NaN
initial amount: NaN

metaR r1575
reactant: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
fast: false
type: Reaction
kinetic law: MODEL1310110002#

metaM leuktrE4 e
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:57462
initial amount: NaN
is: HMDB02200
is: SBO:0000247
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
has only substance units: false
name: leukotriene E4(1-)

metaM CE0713 m
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
is: CHEBI:30623
constant: false
is: SBO:0000247
name: 3-oxolinoleoyl-CoA
boundary condition: false
is: HMDB02329
initial concentration: 1.0
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_3e826f3f_0a63_4da0_a99a_422db23c8ac4
boundary condition: true
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:3945
name: LDHB
is: SBO:0000252
is: P07195
has only substance units: false

metaR O2Stn
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
fast: false
product: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
name: superoxide anion transport via diffusion (nucleus)
reversible: true

metaM tdcoa x
initial concentration: 1.0
initial amount: NaN
is: HMDB01521
boundary condition: false
is: C02593
name: Tetradecanoyl-CoA (n-C14:0CoA)
has only substance units: false
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
constant: false
is: CHEBI:57385
type: Species
is: SBO:0000247

metaR r1928
modifier: MODEL1310110002#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
reactant: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
name: Y+LAT2 Utilized transport

metaR BETALDHxm
reversible: false
kinetic law: MODEL1310110002#
is: SBO:0000176
reactant: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 2 AUTHORS: PMID:15321791 NOTES:MM
name: betaine-aldehyde dehydrogenase, mitochondrial
is described by: ECO:0000000
product: MODEL1310110002#
fast: false

metaR EX dopa LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine exchange
type: Reaction

metaM 1pyr5c m
is: HMDB01301
is: SBO:0000247
name: 1-Pyrroline-5-carboxylate
boundary condition: false
is: C03912
type: Species
is: CHEBI:15893
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_913dc060_2b15_4191_9c35_9e08924b958d
initial amount: NaN
is: Q15181
is: SBO:0000252
type: Species
constant: false
name: PPA1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5464
boundary condition: true

metaM dhap c
constant: false
is: HMDB01473
name: Dihydroxyacetone phosphate
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:57642
initial concentration: 1.0
boundary condition: false
is: C00111
is: http://identifiers.org/pubchem.compound/3411

metaM ksii core4 e
has only substance units: false
is: HMDB00211
is: CHEBI:17268
constant: false
type: Species
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
boundary condition: false
name: keratan sulfate II (core 4-linked)
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

metaM CE2433 m
boundary condition: false
constant: false
notes: FORMULA: C37H56N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,16-17,24-26,30-32,36,47-48H,4-7,10,13-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-,17-16+/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2433
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57795
name: trans,cis,cis-2,7,10-hexadecatrienoyl-CoA
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_efd408c6_1f86_4a11_b836_3ff1f6d73bdc
is: Q15181
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5464
name: PPA1
boundary condition: true
type: Species
constant: false
initial amount: NaN

metaM utp e
constant: false
initial amount: NaN
is: CHEBI:46398
type: Species
initial concentration: 1.0
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00285
name: UTP(4-)

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM strdnccoa m
initial amount: NaN
boundary condition: false
is: C16163
name: stearidonyl coenzyme A
notes: FORMULA: C39H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,14-15,26-28,32-34,38,49-50H,4,7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-,15-14-/t28-,32-,33?,34+,38-/m1/s1
initial concentration: 1.0
type: Species
is: http://identifiers.org/pubchem.compound/47205473
is: SBO:0000247
is: HMDB06519
has only substance units: false
constant: false

metaR PROSTGE2t2
modifier: MODEL1310110002#
type: Reaction
reversible: true
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000269
name: prostaglandin uniport
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
is: SBO:0000185

metaR CYTDK2m
type: Reaction
name: cytidine kinase (ATP), mitochondrial
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
fast: false
reversible: false
kinetic law: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
is: SBO:0000176

metaR r0651
reactant: MODEL1310110002#
is: SBO:0000176
name: Chenodeoxycholate:CoA ligase (AMP-forming) Bile acid biosynthesis EC:6.2.1.7
type: Reaction
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110002#
product: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.2
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 0 AUTHORS: PMID:10749848,PMID:10884298,PMID:15026425,PMID:438652,PMID:6173037 NOTES:
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_7d47a2a9_c4a7_4d58_a77b_4333d3deb1d5
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: O43772
name: SLC25A20
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:788

metaR ABTD
reactant: MODEL1310110002#
type: Reaction
reversible: true
name: L-arabinitol 4-dehydrogenase
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
fast: false

metaR r2312
reversible: true
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
reactant: MODEL1310110002#
is: SBO:0000185
fast: false

metaR O2Stm
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
reversible: true
fast: false
name: superoxide anion transport via diffusion (mitochondria)
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:

metaR r1574
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#

metaR r1929
fast: false
kinetic law: MODEL1310110002#
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110002#
modifier: MODEL1310110002#
reversible: false
is: SBO:0000185
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaR FAOXC102C101m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_657f7204_5b85_4d65_80dd_3a589111eab7
name: SLCO1A2
constant: false
is encoded by: hsa:6579
initial amount: NaN
type: Species
is: P46721
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR ADKd
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
is: SBO:0000176
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000269
name: adenylate kinase (d form)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
type: Reaction
modifier: MODEL1310110002#

metaR ARACHDtr
kinetic law: MODEL1310110002#
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
name: intracellular transport

metaR TCHOLAte
reactant: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
name: bile acid intracellular transport
kinetic law: MODEL1310110002#
reversible: true
is described by: ECO:0000000
product: MODEL1310110002#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_0f2fc65b_b989_4755_89f9_ab60c64b50eb
is: SBO:0000252
is: Q9Y672
constant: false
is encoded by: hsa:29929
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
name: ALG6
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_b09176f2_1439_42bd_8c05_190b192db8c3
type: Species
boundary condition: true
is: SBO:0000252
is: Q9H2X9
name: SLC12A5
initial concentration: NaN
is encoded by: hsa:57468
constant: false
has only substance units: false
initial amount: NaN

metaR EX cit LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Citrate exchange
type: Reaction

metaR MG3er
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
type: Reaction
reversible: false

metaM cs c deg4 l
is: HMDB00812
is: CHEBI:16953
initial amount: NaN
boundary condition: false
notes: FORMULA: C31H49NO29S CHARGE: -2
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
has only substance units: false
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 4

metaR r1298
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110002#
reversible: false
product: MODEL1310110002#
name: Vesicular transport

metaR r2202
reversible: true
kinetic law: MODEL1310110002#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
type: Reaction
reactant: MODEL1310110002#
is: SBO:0000185
modifier: MODEL1310110002#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_b7a92b39_759f_437f_b1f4_bbbf128d9e6c
constant: false
has only substance units: false
is: Q16790
name: CA9
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:768
type: Species

metaR NACHEX4ly
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110002#
type: Reaction
reversible: false
product: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110002#
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110002#

metaR r0541
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 0 AUTHORS: PMID:3081514 NOTES:
modifier: MODEL1310110002#
name: Glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating) Fatty acid metabolism EC:1.3.99.7
product: MODEL1310110002#
reversible: true
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
kinetic law: MODEL1310110002#
fast: false
reactant: MODEL1310110002#

metaM HC01401 m
is: SBO:0000247
type: Species
constant: false
is: CHEBI:27668
initial amount: NaN
name: (S)-3-Hydroxydodecanoyl-CoA
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C33H54N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H58N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-22,26-28,32,41,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t21-,22+,26+,27+,28-,32+/m0/s1 EHMN_ABBREVIATION: C05262
has only substance units: false

metaM HC02205 e
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
is: CHEBI:28099
is: SBO:0000247
constant: false
name: prostaglandin-b2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_cac54bc6_d2dc_4305_a822_216a4f2ec312
initial concentration: NaN
name: TUSC3
constant: false
is: Q13454
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:7991

metaR CITRtm
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
kinetic law: MODEL1310110002#
name: citrulline mitochondrial transport via proton antiport
is: SBO:0000185
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000269
reversible: true
product: MODEL1310110002#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_3928c3e7_a5e9_401b_9f71_3db0c2950dd1
is: SBO:0000252
boundary condition: true
has only substance units: false
is: Q9UGH3
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:9962
name: SLC23A2

metaR NACHEXA22ly
is described by: ECO:0000000
modifier: MODEL1310110002#
name: beta-N-acetylhexosaminidase A, lysosomal
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_d3ee0f15_5b6d_4ff6_8677_16d09bffdbdc
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:10870
has only substance units: false
name: HCST
constant: false
is: Q9UBK5
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_ac26324e_8eb6_4cde_84f5_1388c788ceac
initial concentration: NaN
is: SBO:0000252
constant: false
name: HADH
boundary condition: true
has only substance units: false
is encoded by: hsa:3033
initial amount: NaN
type: Species
is: Q16836

metaR r2201
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110002#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110002#
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_26cfc29a_9b94_43ec_80ce_d74c71bd465d
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:231
boundary condition: true
initial amount: NaN
has only substance units: false
is: P15121
name: AKR1B1

metaR r0801
fast: false
is: SBO:0000185
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110002#
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:

metaM galgbside hs g
name: galactosylgloboside
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:18259
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110002#_0531e2db_2614_4be8_b328_75ae0fbb8676
type: Species
name: _AI024818_1_c
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI024818
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false

metaM idp e
type: Species
initial amount: NaN
boundary condition: false
name: IDP(3-)
initial concentration: 1.0
is: CHEBI:58280
is: SBO:0000247
constant: false
is: HMDB03335
has only substance units: false
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104

metaR GALASE20ly
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23

http://identifiers.org/biomodels.db/MODEL1310110002#_597ea268_f56c_4190_bd88_92ed1582617f
boundary condition: true
name: CHKA
has only substance units: false
is encoded by: hsa:1119
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
constant: false

metaM ksi pre31 g
name: keratan sulfate I biosynthesis, precursor 31
is: HMDB00175
constant: false
is: C00130
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:58053
is: SBO:0000247
has only substance units: false
notes: FORMULA: C227H363N16O189S9X CHARGE: -10

metaR B3GALT3g
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.79
fast: false
is described by: ECO:0000269
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8706.4) or (8706.1) or (8706.3) or (8706.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.79 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
name: Beta-1,3-galactosyltransferase 3
modifier: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_ea1642bb_51b8_4a61_af3c_68aa6cea09f3
is encoded by: hsa:D87002
initial concentration: NaN
is: SBO:0000252
name: _D87002_1_m
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species

metaR r1571
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true

metaM cmpacna g
name: CMP-N-acetyl-beta-neuraminate(2-)
initial amount: NaN
is: HMDB01176
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
is: CHEBI:57812
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaR B3GNT315g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reversible: false
is described by: ECO:0000254
type: Reaction
modifier: MODEL1310110002#
fast: false
is: SBO:0000176
reactant: MODEL1310110002#

metaM HC00591 c
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16769
notes: FORMULA: C5H6NO4 CHARGE: -1 INCHI: InChI=1S/C5H7NO4/c6-4(8)2-1-3(7)5(9)10/h1-2H2,(H2,6,8)(H,9,10)/p-1 EHMN_ABBREVIATION: C00940
name: 2-oxoglutaramate

metaM HC02205 c
has only substance units: false
initial amount: NaN
is: CHEBI:28099
is: SBO:0000247
constant: false
boundary condition: false
type: Species
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
name: prostaglandin-b2
initial concentration: 1.0

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

metaR GLYtp
reversible: true
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:TDV
is described by: ECO:0000000
reactant: MODEL1310110002#
name: glycine passive transport to peroxisome
is: SBO:0000185
fast: false
kinetic law: MODEL1310110002#
type: Reaction

metaM strdnc r
initial amount: NaN
name: stearidonic acid C18:4, n-3
is: C16300
is: http://identifiers.org/pubchem.compound/47205608
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: HMDB06547
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_4d837ec8_facd_4682_9eb3_4f19d3780dfa
boundary condition: true
type: Species
initial amount: NaN
is: Q99643
initial concentration: NaN
is encoded by: hsa:6391
constant: false
name: SDHC
has only substance units: false
is: SBO:0000252

metaM gly c
boundary condition: false
constant: false
name: Glycine
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0
type: Species
is: HMDB00123
is: C00037
is: CHEBI:3339
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_ee2efc41_ef54_454a_ad0a_ebd2bf36e598
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI971036
initial concentration: NaN
name: _AI971036_1_c
type: Species
constant: false
initial amount: NaN
boundary condition: true

metaR G14T8g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
type: Reaction
is: SBO:0000176
modifier: MODEL1310110002#
fast: false
reversible: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.90
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_3613023f_4fd8_48ab_a3ab_5311ee953572
initial amount: NaN
name: SLC23A2
boundary condition: true
constant: false
is encoded by: hsa:9962
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species

metaM hom L c
name: L-homoserine
boundary condition: false
is: HMDB00719
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: CHEBI:15699
constant: false
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_e83674b5_4ab7_415a_aab3_6f654f968591
type: Species
initial concentration: NaN
name: VNN1
is: SBO:0000252
has only substance units: false
is: O95497
initial amount: NaN
boundary condition: true
is encoded by: hsa:8876
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_2aeee9f2_972b_46cf_b020_30dc98903287
is encoded by: hsa:221823
has only substance units: false
boundary condition: true
name: PRPS1L1
is: SBO:0000252
constant: false
initial amount: NaN
type: Species
initial concentration: NaN

metaR r1620
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
reversible: true
type: Reaction
is: SBO:0000185

metaR AKGMALtm
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
name: alpha-ketoglutarate/malate transporter
modifier: MODEL1310110002#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_205754cb_9288_4666_bbac_04ea063d7025
initial amount: NaN
is encoded by: hsa:4713
type: Species
name: NDUFB7
has only substance units: false
constant: false
boundary condition: true
is: P17568
is: SBO:0000252
initial concentration: NaN

metaR GULNDer
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.19 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
is described by: ECO:0000000
name: gulonate dehydrogenase, endoplasmic reticulum
is: SBO:0000176
type: Reaction
reversible: true

metaR FAEL183
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110002#
reversible: false
name: fatty-acyl-CoA elongation (n-C18:3CoA)
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
modifier: MODEL1310110002#
is described by: ECO:0000000

metaR r0321
product: MODEL1310110002#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
is version of: http://identifiers.org/ec-code/6.3.5.2
reactant: MODEL1310110002#

metaR UMPKn
product: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
name: UMP kinase, nuclear
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
reactant: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false

metaR r1570
product: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_10f5346a_9f51_4712_ad73_d1c30b91c496
is: Q5QPH3
name: ACSS2
type: Species
initial amount: NaN
is encoded by: hsa:55902
is: SBO:0000252
has only substance units: false
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_7bb1d8d3_7472_44b2_84d1_bad24ea61d47
boundary condition: true
is: P30048
name: PRDX3
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:10935
is: SBO:0000252
initial amount: NaN

metaR r1299
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110002#
name: Vesicular transport
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false

metaR PE HSter
is: SBO:0000185
reactant: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:
fast: false
name: phosphatidylethanolamine scramblase
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110002#

metaR r0193
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
reactant: MODEL1310110002#
is: SBO:0000176
reversible: true
product: MODEL1310110002#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_4a29d3ac_a09d_4c24_be65_3ed03d7a689b
has part: P55084
type: Species
is: SBO:0000297
name: HADHA:HADHB
initial amount: NaN
is encoded by: hsa:3032
has only substance units: false
is encoded by: hsa:3030
initial concentration: NaN
has part: E9KL44
boundary condition: true
constant: false

metaM itacon m
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h1-2H2,(H,6,7)(H,8,9)/p-2 EHMN_ABBREVIATION: C00490
is: SBO:0000247
is: CHEBI:17240
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB02092
name: itaconate(2-)

http://identifiers.org/biomodels.db/MODEL1310110002#_8aab8fdd_506b_4e65_b3b0_6819b6276300
initial concentration: NaN
is encoded by: hsa:124454
constant: false
has only substance units: false
name: EARS2
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
is: Q5JPH6

metaR ASCBt
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15705056,PMID:3715892 NOTES:NCD
type: Reaction
name: L-ascorbate transport via facilitated diffusion
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_99275dd5_d171_489e_9a4c_8e2d104f8736
has only substance units: false
is encoded by: hsa:4831
boundary condition: true
name: NME1:NME2
is: SBO:0000297
has part: P15531
initial amount: NaN
type: Species
initial concentration: NaN
has part: P22392
is encoded by: hsa:4830
constant: false

metaM hmgcoa m
initial amount: NaN
is: SBO:0000247
name: Hydroxymethylglutaryl-CoA
is: CHEBI:15467
type: Species
boundary condition: false
is: HMDB01375
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial concentration: 1.0
constant: false
has only substance units: false

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaR EX arach LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for arachidate
type: Reaction

metaR O2Stx
name: superoxide anion transport via diffusion (peroxisome)
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110002#
fast: false
reversible: true
is: SBO:0000185

metaR r0545
type: Reaction
fast: false
kinetic law: MODEL1310110002#
is: SBO:0000176
reactant: MODEL1310110002#
is described by: ECO:0000000
name: Phenylacetaldehyde:NAD+ oxidoreductase Phenylalanine metabolism / Styrene degradation EC:1.2.1.5 EC:1.2.1.39
is version of: http://identifiers.org/ec-code/3.6.1.5
product: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:15230339 NOTES:
reversible: true

metaM nac e
initial amount: NaN
type: Species
is: HMDB01488
is: SBO:0000247
constant: false
notes: FORMULA: C6H4NO2 CHARGE: -1
initial concentration: 1.0
is: C00253
has only substance units: false
boundary condition: false
is: CHEBI:0
name: Nicotinate

http://identifiers.org/biomodels.db/MODEL1310110002#_b7b365f9_db15_4f4d_b1e5_de54ccea19ae
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
name: ACAT1
is: P24752
is encoded by: hsa:38
is: SBO:0000252
type: Species
boundary condition: true

metaM prostgf2 e
boundary condition: false
is: HMDB01139
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
name: prostaglandin F2alpha(1-)
initial concentration: 1.0
is: CHEBI:57404

http://identifiers.org/biomodels.db/MODEL1310110002#_1cf85f67_cd14_4dc4_8a96_0037dfbd6b97
is encoded by: hsa:27068
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: PPA2
initial concentration: NaN
has only substance units: false

metaR HIStiDF
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#
name: L-histidine transport via diffusion (extracellular to cytosol)
type: Reaction
product: MODEL1310110002#
is: SBO:0000185
fast: false
is described by: ECO:0000269
reversible: false

metaR r1621
modifier: MODEL1310110002#
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#

metaR EX ncam LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinamide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_0b7bea64_c9bf_4675_8e1b_e5627ac7ef67
type: Species
boundary condition: true
is: P15291
is: SBO:0000252
name: B4GALT1
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2683

metaR GAMt1r
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (6513.1) or (6517.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:
modifier: MODEL1310110002#
is described by: ECO:0000269
kinetic law: MODEL1310110002#
reversible: true
is: SBO:0000185
reactant: MODEL1310110002#
product: MODEL1310110002#
name: glucosamine transport (uniport)

metaM g3p c
is: CHEBI:58027
is: HMDB01112
is: http://identifiers.org/pubchem.compound/3930
name: Glyceraldehyde 3-phosphate
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
constant: false
is: C00661

metaM hexdectecoa m
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB02288
type: Species
name: 2,4,7,10-hexadecatetraenoylcoa
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110002#_21cec324_5eaf_4d00_9693_3b45a9a1fe93
initial concentration: NaN
initial amount: NaN
name: PKLR
boundary condition: true
type: Species
is encoded by: hsa:5313
constant: false
has only substance units: false
is: SBO:0000252

metaM dgchol e
is: HMDB00637
boundary condition: false
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
type: Species
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:36252
name: glycochenodeoxycholate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_15d64960_dd7c_46bf_bd2e_90e722cb2ecd
boundary condition: true
constant: false
name: FOLR3
is: Q05C14
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2352

metaM trdox c
boundary condition: false
name: Oxidized thioredoxin
has only substance units: false
initial amount: NaN
is: CHEBI:18191
is: C00343
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247

metaR PItn
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110002#
fast: false
reversible: true
type: Reaction
name: phosphate transport, nuclear
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110002#

metaM 3hmbcoa m
type: Species
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: CHEBI:57312
initial concentration: 1.0
is: HMDB01356

http://identifiers.org/biomodels.db/MODEL1310110002#_a4cbe227_d558_4340_9691_c3e520b9a024
is: SBO:0000252
is encoded by: hsa:6534
has only substance units: false
constant: false
boundary condition: true
name: SLC6A7
is: Q99884
initial amount: NaN
type: Species
initial concentration: NaN

metaR ACOAD9m
reversible: false
name: acyl-CoA dehydrogenase (isobutyryl-CoA), mitochondrial
kinetic law: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000176
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (27034.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM

metaR r0191
fast: false
reversible: false
modifier: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
product: MODEL1310110002#
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
is version of: http://identifiers.org/ec-code/1.2.1.24

http://identifiers.org/biomodels.db/MODEL1310110002#_ced5db31_6360_4b00_ae23_bb7c0398e494
initial concentration: NaN
constant: false
has only substance units: false
is: O60762
is: SBO:0000252
boundary condition: true
name: DPM1
is encoded by: hsa:8813
type: Species
initial amount: NaN

metaR ABO9g
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
reactant: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.37
type: Reaction
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_15c8718e_92f5_4082_9008_ea948bf3902f
constant: false
is encoded by: hsa:84701
is: Q96KJ9
has only substance units: false
boundary condition: true
name: COX4I2
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaM cl e
boundary condition: false
initial concentration: 1.0
is: C00115
is: CHEBI:3966
is: HMDB00492
notes: FORMULA: Cl CHARGE: -1
constant: false
name: Chloride
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaM hom L e
is: CHEBI:15699
initial amount: NaN
initial concentration: 1.0
is: HMDB00719
has only substance units: false
type: Species
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
constant: false
name: L-homoserine
is: SBO:0000247
boundary condition: false

metaM HC01522 c
name: Gentisate aldehyde
is: CHEBI:28508
is: SBO:0000247
type: Species
notes: FORMULA: C7H6O3 CHARGE: 0 INCHI: InChI=1S/C7H6O3/c8-4-5-3-6(9)1-2-7(5)10/h1-4,9-10H EHMN_ABBREVIATION: C05585
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_013fbeea_b2e2_4a7d_8b79_b68229cc242a
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:230
boundary condition: true
constant: false
name: ALDOC
has only substance units: false
is: P09972
initial concentration: NaN

metaR r1622
kinetic law: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
is described by: ECO:0000000
fast: false
product: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_69f2bd8a_8a2a_4ee0_988e_e235546da2b8
is: Q99798
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:50
name: ACO2

http://identifiers.org/biomodels.db/MODEL1310110002#_6db9235b_2545_432a_8637_9d5bb5adb9c9
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: GLUL
constant: false
is encoded by: hsa:2752
is: P15104
initial concentration: NaN

metaM ksi pre29 g
is: CHEBI:28067
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
has only substance units: false
type: Species
constant: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 29
is: SBO:0000247

metaR EX ksii core4 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate II (core 4-linked) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_4e4dec58_86b0_4e81_8070_fa58e46ffc98
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:AI601100
constant: false
name: _AI601100_1_m
type: Species
initial concentration: NaN
initial amount: NaN

metaM ser L e
constant: false
is: SBO:0000247
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
is: CHEBI:17115
boundary condition: false
initial amount: NaN
name: L-serine
has only substance units: false
is: HMDB00187
initial concentration: 1.0
type: Species

metaR ACACt2m
reversible: true
product: MODEL1310110002#
name: Acetoacetate mitochondrial transport via H+ symport
modifier: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:28726,PMID:627555 NOTES:IT, TDV changed name from "tm2" to "t2m" - NCD

metaR 1PPDCRp
type: Reaction
reversible: false
kinetic law: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
is: SBO:0000176
product: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
name: delta1-piperideine-2-carboxylate reductase, perixosomal

metaM hista e
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
name: histamium
constant: false
has only substance units: false
initial concentration: 1.0
is: HMDB00870
is: CHEBI:58432
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388

metaR r0870
is version of: http://identifiers.org/ec-code/3.6.1.1
is version of: http://identifiers.org/ec-code/3.6.4.13
reactant: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
name: Facilitated diffusion
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is: SBO:0000185
product: MODEL1310110002#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.72
is version of: http://identifiers.org/ec-code/3.1.3.4
kinetic law: MODEL1310110002#

metaR SO4tl
fast: false
is described by: ECO:0000269
reactant: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
name: Sulfate transport (lysosome)
is: SBO:0000185
reversible: true

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

metaM nac c
type: Species
initial amount: NaN
is: HMDB01488
is: SBO:0000247
notes: FORMULA: C6H4NO2 CHARGE: -1
constant: false
initial concentration: 1.0
has only substance units: false
is: C00253
boundary condition: false
name: Nicotinate
is: CHEBI:0

http://identifiers.org/biomodels.db/MODEL1310110002#_8d12ee1b_2c00_4de7_8388_42a2a5f5113c
is: Q9BY49
is: SBO:0000252
initial amount: NaN
name: PECR
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:55825
constant: false
boundary condition: true

metaR r0547
type: Reaction
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:17379813,PMID:18621017 NOTES:
name: Aldehyde:NADP+ oxidoreductase Phenylalanine metabolism EC:1.2.1.5
fast: false
is: SBO:0000176
reactant: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.17.1.4
modifier: MODEL1310110002#
reversible: true

metaM prostgf2 c
is: CHEBI:57404
is: SBO:0000247
is: HMDB01139
constant: false
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00639
initial amount: NaN
name: prostaglandin F2alpha(1-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_9ff2e30b_a072_402b_abc2_8d64894abd69
is encoded by: hsa:84812
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is: Q9BRC7
has only substance units: false
name: PLCD4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_af1d8648_36bf_4ad6_8259_5ef74b787eaa
is: SBO:0000252
initial amount: NaN
name: RRM2
initial concentration: NaN
is: P31350
has only substance units: false
boundary condition: true
type: Species
constant: false
is encoded by: hsa:6241

metaM pail5p hs n
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: SBO:0000247
is: CHEBI:57795
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species

metaR TMDK1
notes: GENE_ASSOCIATION: (7084.1) or (7083.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.21
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
name: thymidine kinase (ATP:thymidine)
kinetic law: MODEL1310110002#

metaR ARGtm
fast: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
modifier: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
name: arginine mitochondrial transport via ornithine carrier
is: SBO:0000185

metaM r1p c
is: SBO:0000247
type: Species
initial amount: NaN
is: C00442
boundary condition: false
is: CHEBI:57720
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
is: HMDB01489
name: alpha-D-Ribose 1-phosphate
has only substance units: false
initial concentration: 1.0
constant: false

metaR EX leuktrB4 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene B4 exchange
type: Reaction

metaM dgchol c
is: CHEBI:36252
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
constant: false
is: HMDB00637
name: glycochenodeoxycholate
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_70ca7621_4ac9_492a_9a0a_ff1b8302c8b8
is: D9HTE9
constant: false
is encoded by: hsa:6576
has only substance units: false
boundary condition: true
name: SLC25A1
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252

metaR r1623
is described by: ECO:0000000
modifier: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
fast: false
product: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true

metaM 3hpcoa m
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C24H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C24H40N7O18P3S/c1-24(2,19(36)22(37)27-5-3-14(33)26-6-8-53-15(34)4-7-32)10-46-52(43,44)49-51(41,42)45-9-13-18(48-50(38,39)40)17(35)23(47-13)31-12-30-16-20(25)28-11-29-21(16)31/h11-13,17-19,23,32,35-36H,3-10H2,1-2H3,(H,26,33)(H,27,37)(H,41,42)(H,43,44)(H2,25,28,29)(H2,38,39,40)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01557 EHMN_ABBREVIATION: C05668
is: HMDB06807
name: 3-hydroxypropanoyl-CoA(4-)
boundary condition: false
is: CHEBI:58528
initial concentration: 1.0
type: Species

metaM m2mpdol U c
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
is: CHEBI:28049
type: Species
has only substance units: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_5175ad0e_1c92_4684_966d_1301a957024f
is encoded by: hsa:10558
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: O15269
constant: false
initial amount: NaN
name: SPTLC1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_4a8257d5_5d9f_47d4_931f_cfe1bb16fb2c
is: SBO:0000252
initial amount: NaN
type: Species
is: Q9UNP4
has only substance units: false
name: ST3GAL5
is encoded by: hsa:8869
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_b58ce482_cf50_457d_a5da_d8a288ff4e60
is encoded by: hsa:9245
is: O95395
initial amount: NaN
boundary condition: true
name: GCNT3
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaM cl c
initial amount: NaN
is: HMDB00492
is: C00115
has only substance units: false
constant: false
name: Chloride
type: Species
boundary condition: false
is: CHEBI:3966
is: SBO:0000247
notes: FORMULA: Cl CHARGE: -1
initial concentration: 1.0

metaR GLCNACT U
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110002#
reversible: false
product: MODEL1310110002#
is: SBO:0000176
name: UDP-GlcNAc:N-acetyl-D-glucosaminyl diphosphodolichol N-acetyl-D-glucosaminyltransferase (uterus)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.141 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_18ece6cf_df9c_4c4d_8f45_ecf7c6af6bdb
is: B3KXK1
type: Species
boundary condition: true
name: SLC26A9
initial concentration: NaN
has only substance units: false
is encoded by: hsa:115019
is: SBO:0000252
constant: false
initial amount: NaN

metaR EX malthx LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltohexaose exchange
type: Reaction

metaM ser L c
constant: false
is: SBO:0000247
boundary condition: false
name: L-serine
has only substance units: false
is: CHEBI:17115
initial amount: NaN
initial concentration: 1.0
is: HMDB00187
notes: FORMULA: C3H7NO3 CHARGE: 0 INCHI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00068
type: Species

metaM ksii core4 deg3 l
type: Species
constant: false
notes: FORMULA: C66H107N6O51S2X CHARGE: -2
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:12936
name: keratan sulfate II (core 4-linked), degradation product 3
boundary condition: false
is: HMDB00143
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_52fd091b_9ba9_4d96_9568_e34dabfcf3f4
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
name: B3GALT5
boundary condition: true
constant: false
is encoded by: hsa:10317
has only substance units: false

metaR CSPG Ctly
name: chondroitin sulfate C transport, extracellular to lysosome
product: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
fast: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_6987f138_6383_4809_92d1_4132517b00ae
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:4535
boundary condition: true
is: Q85KV6
constant: false
name: ND1
has only substance units: false
initial amount: NaN

metaR r1624
reactant: MODEL1310110002#
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR AG13T5g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaM ksii core4 pre2 g
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C47H76N4O33X CHARGE: -1
is: CHEBI:58053
is: HMDB00175
name: keratan sulfate II boisynthesis, precursor 2
has only substance units: false
type: Species
is: C00130
is: SBO:0000247
constant: false

metaR r1847
reactant: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
type: Reaction
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
product: MODEL1310110002#
reversible: false
is: SBO:0000185

metaM hista c
constant: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
name: histamium
is: HMDB00870
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:58432

metaR GLYtm
type: Reaction
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
product: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
is: SBO:0000185
reversible: true
name: glycine passive transport to mitochondria
fast: false

metaR S6T5g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
product: MODEL1310110002#
fast: false
modifier: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000000

metaR RE3628M
is version of: http://identifiers.org/ec-code/1.1.1.35
fast: false
modifier: MODEL1310110002#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/5.3.3.8
is described by: ECO:0000000
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
name: RE3628
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110002#
is: SBO:0000176

metaM asp L m
is: CHEBI:29991
initial concentration: 1.0
is: SBO:0000247
is: HMDB00191
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
name: L-aspartate(1-)
type: Species
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055

metaR CO2t
name: CO2 transporter via diffusion
kinetic law: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
is: SBO:0000185
reversible: true

metaR r2195
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
modifier: MODEL1310110002#
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
type: Reaction
is: SBO:0000185
fast: false

metaR r1090
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110002#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110002#
reversible: false
is: SBO:0000185
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
kinetic law: MODEL1310110002#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_1be7eecb_f837_4ebe_9cda_0522eeaba132
has only substance units: false
is encoded by: hsa:374291
is: O75251
type: Species
initial concentration: NaN
initial amount: NaN
name: NDUFS7
constant: false
is: SBO:0000252
boundary condition: true

metaM m8masn g
initial amount: NaN
is: C05876
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
type: Species
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C70H117N2O55X CHARGE: 0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_d7c44a7f_ed9d_4767_801d_56444eeb3172
boundary condition: true
is encoded by: hsa:1962
initial amount: NaN
initial concentration: NaN
is: Q9NY65
is: SBO:0000252
has only substance units: false
name: EHHADH
constant: false
type: Species

metaR r2122
kinetic law: MODEL1310110002#
product: MODEL1310110002#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110002#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000

metaM strdnc l
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: stearidonic acid C18:4, n-3
has only substance units: false
is: HMDB06547
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
is: SBO:0000247
constant: false
type: Species
is: http://identifiers.org/pubchem.compound/47205608
is: C16300

metaM ncam c
boundary condition: false
name: Nicotinamide
is: C00153
is: HMDB01406
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C6H6N2O CHARGE: 0
is: SBO:0000247
is: CHEBI:0

metaM 6a2ohxnt x
boundary condition: false
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-4-2-1-3-5(8)6(9)10/h1-4,7H2,(H,9,10) EHMN_ABBREVIATION: C03239
is: CHEBI:17534
is: HMDB12151
constant: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: 6-amino-2-oxohexanoic acid

metaM CE0849 m
boundary condition: false
is: CHEBI:57795
name: cis,cis-palmito-7,10-dienoyl-CoA
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849

http://identifiers.org/biomodels.db/MODEL1310110002#_d482c4aa_8d12_4f22_825e_e6356077f9d6
name: SLCO1B1
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is encoded by: hsa:10599
is: Q9Y6L6
initial amount: NaN
initial concentration: NaN

metaR FAOXC143C123m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:3-->C12:3)m
type: Reaction

metaR CHOLtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
type: Reaction
kinetic law: MODEL1310110002#
reversible: true
name: Choline transport, nuclear through pores
is described by: ECO:0000000
fast: false
is: SBO:0000185
reactant: MODEL1310110002#
product: MODEL1310110002#

metaM asn L c
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
name: L-asparagine
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00168
is: CHEBI:17196
constant: false
is: SBO:0000247

metaM din c
is: CHEBI:28997
boundary condition: false
is: HMDB00071
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
name: Deoxyinosine
initial amount: NaN
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: C05512
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_65e2f505_cf5c_488b_a916_bfd78ed6a35e
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110002#_474e12e3_b536_43df_a8ce_c89413a8d9da
initial amount: NaN
name: PEMT
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:10400

metaM estradiol c
initial amount: NaN
is: HMDB00151
constant: false
name: estradiol
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
type: Species
is: CHEBI:16469
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_7e06725f_d46c_4d9f_a7fb_52a089ec042a
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:30
name: ACAA1
type: Species
is: Q96CA6

metaR r2123
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110002#
product: MODEL1310110002#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR PIt7
reversible: true
is described by: ECO:0000269
is: SBO:0000185
modifier: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
name: phosphate transport in/out via three Na+ symporter
product: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_7998eac7_d8f7_458a_9cdf_ff9ea46fa96a
has only substance units: false
is: P23434
is: SBO:0000252
name: GCSH
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2653

metaR ATPtx
reversible: true
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
name: ATP transporter, peroxisomal
type: Reaction
is described by: ECO:0000000
product: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000185

metaM HC02217 e
is: SBO:0000247
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
is: CHEBI:27647
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: prostaglandin-g2

metaM val L m
initial amount: NaN
is: HMDB00883
boundary condition: false
is: CHEBI:16414
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial concentration: 1.0
has only substance units: false
name: L-valine

http://identifiers.org/biomodels.db/MODEL1310110002#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEtg
product: MODEL1310110002#
type: Reaction
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#
is: SBO:0000185
reactant: MODEL1310110002#
name: blood group intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
reversible: true

metaM udpgal c
type: Species
is: HMDB00302
name: UDP-D-galactose(2-)
initial concentration: 1.0
constant: false
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:58439
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_13e920ec_aca6_41f3_85fb_3e7ed7edd30d
type: Species
boundary condition: true
initial amount: NaN
name: TMEM91
is: C9JZ62
constant: false
is encoded by: hsa:641649
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_77757aff_4103_4145_a6f5_b32872203de1
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is: Q6IRT1
boundary condition: true
is encoded by: hsa:128
name: ADH5
type: Species
is: SBO:0000252

metaR LINKDEG4ly
reactant: MODEL1310110002#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110002#
reversible: false
name: degradation of proteoglycan linkage region, lysosomal
product: MODEL1310110002#
fast: false
is described by: ECO:0000000

metaM dcdp c
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
is: C00705
boundary condition: false
is: CHEBI:58593
initial amount: NaN
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: HMDB01245
name: dCDP

http://identifiers.org/biomodels.db/MODEL1310110002#_00ba8f81_ba35_4016_bd6d_a3b39fd2557b
is: SBO:0000252
is encoded by: hsa:6536
type: Species
initial concentration: NaN
constant: false
name: SLC6A9
is: B7Z3W8
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_5c9b3565_a929_4197_91b2_87aff5d8439b
name: ACAA1
constant: false
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:30
is: Q96CA6
initial amount: NaN
initial concentration: NaN

metaR r2193
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reactant: MODEL1310110002#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110002#

metaM retinol 9 cis c
type: Species
name: 9-cis-retinol
is: CHEBI:17336
constant: false
is: HMDB06217
boundary condition: false
initial amount: NaN
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR UMPK2
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
fast: false
is described by: ECO:0000269
is: SBO:0000176
name: UMP kinase (CTP)
kinetic law: MODEL1310110002#
type: Reaction

metaR ACETONEt2
product: MODEL1310110002#
type: Reaction
name: acetone transport via proton symport
reversible: true
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
modifier: MODEL1310110002#
is described by: ECO:0000269
is: SBO:0000185
kinetic law: MODEL1310110002#
fast: false
reactant: MODEL1310110002#

metaR r2120
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
product: MODEL1310110002#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
reactant: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#

metaM ncam e
is: HMDB01406
is: CHEBI:0
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C6H6N2O CHARGE: 0
has only substance units: false
boundary condition: false
initial amount: NaN
is: C00153
constant: false
name: Nicotinamide

metaM hdca l
has only substance units: false
is: SBO:0000247
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: HMDB00220
initial concentration: 1.0
type: Species
name: palmitate
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:7896

http://identifiers.org/biomodels.db/MODEL1310110002#_91e58ea5_d2d4_4f6f_a4f4_b9fccc0ef6a3
is encoded by: hsa:2271
type: Species
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is: P07954
initial amount: NaN
name: FH

metaM mag hs c
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB12130
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
constant: false
name: monoacylglycerol 2
is: CHEBI:16987
is: SBO:0000247

metaM doldp U r
is: SBO:0000247
notes: FORMULA: C1025H1670O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:15750
boundary condition: false
name: Dolichol diphosphate, human uterine homolog
constant: false
initial amount: NaN

metaR GALt4
reactant: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
fast: false
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000269
name: galactose transport via sodium symport
reversible: true
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_25d810ff_220a_4743_9255_5d0c8ea1ed8f
name: _H17063_1_m
is: SBO:0000252
is encoded by: hsa:H17063
constant: false
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true

metaR RE1709N
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/4.2.1.96
modifier: MODEL1310110002#
is: SBO:0000176
name: RE1709
type: Reaction
reactant: MODEL1310110002#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
kinetic law: MODEL1310110002#
reversible: true

metaR RE3568C
reactant: MODEL1310110002#
name: RE3568
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_3ec387f6_ffaa_48c4_bc1d_1b2991956a21
is: SBO:0000252
is encoded by: hsa:1718
constant: false
type: Species
is: Q15392
has only substance units: false
initial amount: NaN
boundary condition: true
name: DHCR24
initial concentration: NaN

metaR FAOXC140
product: MODEL1310110002#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of long chain fatty acid
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is described by: ECO:0000269
fast: false
reactant: MODEL1310110002#
reversible: false

metaR CITL
kinetic law: MODEL1310110002#
reversible: false
modifier: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (171425.1) or (171425.2) SUBSYSTEM: Citric acid cycle EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:JLR
name: Citrate lyase
product: MODEL1310110002#
type: Reaction

metaM CE2422 m
is: CHEBI:28387
boundary condition: false
type: Species
has only substance units: false
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA
is: HMDB11123
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
is: SBO:0000247

metaR r0186
is described by: ECO:0000000
reactant: MODEL1310110002#
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
is: SBO:0000176
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
modifier: MODEL1310110002#
product: MODEL1310110002#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_3f642945_3d34_4b32_b9a0_60e41afcc7ac
has only substance units: false
is encoded by: hsa:4725
is: Q6IBA0
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: NDUFS5
boundary condition: true
constant: false

metaR UMPK3
fast: false
is described by: ECO:0000269
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
product: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: UMP kinase (UTP)

metaM occoa m
is: CHEBI:57386
constant: false
is: HMDB01070
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
type: Species
is: C01944
name: Octanoyl-CoA (n-C8:0CoA)
initial concentration: 1.0
initial amount: NaN

metaM rib D e
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: CHEBI:16988
boundary condition: false
name: D-ribose
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial amount: NaN
initial concentration: 1.0
is: HMDB00283

http://identifiers.org/biomodels.db/MODEL1310110002#_2535fc3c_4895_4c8d_aa49_3c775ab44ab7
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
name: AKR1A1
initial concentration: NaN
boundary condition: true
is encoded by: hsa:10327
constant: false

metaM Rtotalcoa c
constant: false
is: CHEBI:16189
name: R total Coenzyme A
is: HMDB01448
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR FAOXC200180m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reversible: false
modifier: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c20:0 -> c18:0 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000000
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110002#
name: Beta oxidation of long chain fatty acid

metaR IMPC
name: IMP cyclohydrolase
type: Reaction
modifier: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.1.2.3
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_d246b897_5a59_496e_803a_1b1e43440b7f
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: O75521
name: ECI2
constant: false
initial concentration: NaN
is encoded by: hsa:10455
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_dc113011_0762_410b_a318_a88b10cefb14
initial amount: NaN
boundary condition: true
is: O00142
initial concentration: NaN
is encoded by: hsa:7084
name: TK2
has only substance units: false
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_b4bb102d_5d88_4e86_9c1e_8b8aaa770771
name: ALDH3A1
boundary condition: true
constant: false
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:218
initial amount: NaN
is: P30838

metaR r2121
kinetic law: MODEL1310110002#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110002#
type: Reaction
is: SBO:0000185
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110002#

metaM Rtotal2 c
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: C00055
is: CHEBI:60377
constant: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
type: Species
name: R total 2 position
boundary condition: false
initial amount: NaN
is: HMDB00095

http://identifiers.org/biomodels.db/MODEL1310110002#_3bcb1935_9fd8_4504_b81f_594b199f1b7e
initial amount: NaN
is: B4DK61
type: Species
constant: false
name: ACOX1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:51

metaM estradiol e
type: Species
constant: false
initial concentration: 1.0
is: CHEBI:16469
name: estradiol
is: HMDB00151
is: SBO:0000247
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
has only substance units: false
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_6047f10f_57e8_449d_ad2d_30002eb54cc6
has only substance units: false
name: BTD
is: SBO:0000252
is encoded by: hsa:686
initial concentration: NaN
initial amount: NaN
is: P43251
boundary condition: true
type: Species
constant: false

metaM e4hglu m
boundary condition: false
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
is: CHEBI:6331
is: SBO:0000247
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
name: erythro-4-hydroxy-L-glutamate(1-)
type: Species
is: HMDB02273

metaR 3MOBte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: Transport of 3-methyl-2-oxobutanoate
reactant: MODEL1310110002#
fast: false
type: Reaction
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#

metaR RE2814M
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is: SBO:0000176
name: RE2814
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#

metaR AIRCr
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110002#
name: phosphoribosylaminoimidazole carboxylase
modifier: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
reversible: true
fast: false
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/6.3.2.6

metaR VD3
name: Vitamin D3 formation
reactant: MODEL1310110002#
is described by: ECO:0000134
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
type: Reaction
kinetic law: MODEL1310110002#
is: SBO:0000176
fast: false
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_3fc7fe70_4763_4b82_89e3_3d587a5c2211
name: ALDH2
constant: false
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:217
initial concentration: NaN
is: P05091

metaR MCPST
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.8.1.2
reactant: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (4357.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.8.1.2 Confidence Level: 4 AUTHORS: PMID:4828222 NOTES:MM AMF. assay developed to find activity in red and white blood cells
name: 3-mercaptopyruvate sulfurtransferase
is described by: ECO:0000134
is: SBO:0000176
type: Reaction

metaR CYTK1m
product: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000134
type: Reaction
reversible: true
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
kinetic law: MODEL1310110002#
fast: false
name: cytidylate kinase (CMP),mitochondrial

metaR EHGLAT2m
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
is version of: http://identifiers.org/ec-code/2.6.1.1
kinetic law: MODEL1310110002#
is: SBO:0000176
reversible: false
is described by: ECO:0000304
modifier: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
fast: false
reactant: MODEL1310110002#
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial

metaR B3GNT51g
is described by: ECO:0000304
modifier: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
reversible: false
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (84002.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
is: SBO:0000176
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
kinetic law: MODEL1310110002#

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR UMPK4
type: Reaction
name: UMP kinase (GTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false
reversible: true
kinetic law: MODEL1310110002#
is: SBO:0000176

metaR r2126
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110002#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
modifier: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR NADPtru
is described by: ECO:0000000
name: NADP transporter, endoplasmic reticulum
kinetic law: MODEL1310110002#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
fast: false
product: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000185

metaR B3GNT39g
modifier: MODEL1310110002#
reversible: false
kinetic law: MODEL1310110002#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
fast: false
type: Reaction
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176

metaR r0295
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
fast: false
reactant: MODEL1310110002#
is: SBO:0000176
name: glycine synthase Nitrogen metabolism EC:2.1.2.10
reversible: false
kinetic law: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110002#
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_c10c5d4b_6c61_4469_831a_e1fb85a3823a
is: Q16851
is: SBO:0000252
boundary condition: true
is encoded by: hsa:7360
initial amount: NaN
name: UGP2
has only substance units: false
constant: false
type: Species
initial concentration: NaN

metaR ILEt5m
kinetic law: MODEL1310110002#
name: Isoleucine mitochondrial transport
product: MODEL1310110002#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_22221122_33ef_42bc_a3b3_99a1549fc3bb
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:954
type: Species
has only substance units: false
constant: false
name: ENTPD2
is: Q5SPY7
initial amount: NaN

metaM HC00319 c
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
constant: false
is: CHEBI:30794
type: Species
has only substance units: false
name: Malonate
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_f109c660_61e9_4f23_9334_b653b0613012
boundary condition: true
is encoded by: hsa:6528
is: Q92911
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: SLC5A5
initial concentration: NaN

metaM fad m
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
is: C00016
is: HMDB01248
is: CHEBI:16238
name: Flavin adenine dinucleotide oxidized
is: SBO:0000247

metaR S6T3g
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.21
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false
type: Reaction
reactant: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.8.2.17
modifier: MODEL1310110002#
fast: false

metaR ACCOAC
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

metaR r2127
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110002#
product: MODEL1310110002#
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#

metaR UMPK5
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
name: UMP kinase (dATP)
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
fast: false

metaM HC02210 c
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
name: prostaglandin-d3
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
is: CHEBI:34939
is: SBO:0000247
initial amount: NaN

metaR AG13T12g
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
modifier: MODEL1310110002#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110002#

metaM dgchol x
type: Species
initial concentration: 1.0
notes: FORMULA: C26H43NO5 CHARGE: 0 INCHI: InChI=1S/C26H43NO5/c1-15(4-7-22(30)27-14-23(31)32)18-5-6-19-24-20(9-11-26(18,19)3)25(2)10-8-17(28)12-16(25)13-21(24)29/h15-21,24,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32)/p-1/t15-,16+,17-,18-,19+,20+,21-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01472
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:36252
is: HMDB00637
constant: false
name: glycochenodeoxycholate

metaR S6T18g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.17
fast: false
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.8.2.21
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD

metaR Htr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110002#
fast: false
reversible: true
type: Reaction
name: H transporter, endoplasmic reticulum
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#

metaM ksii core2 pre10 g
type: Species
notes: FORMULA: C81H130N6O64S2X CHARGE: -3
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 10
initial concentration: 1.0
is: CHEBI:28067
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR r1816
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
product: MODEL1310110002#
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110002#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110002#
fast: false

metaR ACOAD10m
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
kinetic law: MODEL1310110002#
product: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
is described by: ECO:0000269
is: SBO:0000176
reversible: false
type: Reaction

metaM HC01408 m
type: Species
boundary condition: false
is: CHEBI:27648
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: 3-Oxohexanoyl-CoA
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_42e391f3_fb35_4059_90b1_fc4c6f4aab28
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: PIP4K2B
initial amount: NaN
is encoded by: hsa:8396
constant: false
is: P78356

metaM prostge1 e
initial concentration: 1.0
is: CHEBI:57397
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: prostaglandin E1(1-)
type: Species
has only substance units: false
is: HMDB01442

metaR XYLtly
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is: SBO:0000185
product: MODEL1310110002#
type: Reaction
name: Xylose efflux from lysosome
is described by: ECO:0000000
reactant: MODEL1310110002#
reversible: false
fast: false

metaR GULN3D
fast: false
name: L-gulonate 3-dehydrogenase
type: Reaction
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
kinetic law: MODEL1310110002#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110002#
is: SBO:0000176

metaR FAOXC14DCC12DCx
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14DC-->C12DC)x
type: Reaction

metaM glx x
name: glyoxylate
is: SBO:0000247
is: CHEBI:36655
type: Species
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
constant: false
is: HMDB00119

metaR r2124
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110002#
type: Reaction
fast: false
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
reactant: MODEL1310110002#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_fe94b1f9_6771_49b1_b392_b304c48a3d7c
type: Species
initial concentration: NaN
name: NDUFB6
is encoded by: hsa:4712
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is: O95139

metaR RE2649C
fast: false
reactant: MODEL1310110002#
type: Reaction
name: RE2649
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:11013297 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.65

metaR FUMSO4tm
is described by: ECO:0000269
product: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000185
reversible: true
type: Reaction
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Fumarate:sulfate antiport, mitochondrial

metaR UMPK6
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
product: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
name: UMP kinase (dCTP)

metaM bamppald c
boundary condition: false
is: HMDB01106
is: http://identifiers.org/pubchem.compound/7975
is: C05665
constant: false
is: SBO:0000247
name: beta-Aminopropion aldehyde
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665

http://identifiers.org/biomodels.db/MODEL1310110002#_d51a75ba_af1d_4610_bbc6_9ef779122b47
is encoded by: hsa:8818
is: O94777
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
name: DPM2
boundary condition: true
has only substance units: false

metaR G14T5g
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110002#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90

http://identifiers.org/biomodels.db/MODEL1310110002#_828f6498_5cf8_4007_a012_d7de773a500f
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: B4DK61
name: ACOX1
is: SBO:0000252
is encoded by: hsa:51
initial concentration: NaN
type: Species

metaR ETF
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
modifier: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110002#
reversible: false
fast: false
name: electron transfer flavoprotein
reactant: MODEL1310110002#

metaM sbt D c
is: HMDB00247
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
initial concentration: 1.0
is: CHEBI:17924
constant: false
is: SBO:0000247
name: D-glucitol
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species

metaR r0960
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.65.1.1
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:1554704,PMID:18021224,PMID:4553030,PMID:8725559 NOTES:
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
fast: false

metaR RE3421R
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:11786541,PMID:8521498 NOTES:
name: RE3421
is: SBO:0000176

metaM din e
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
is: SBO:0000247
constant: false
is: HMDB00071
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
name: Deoxyinosine
initial concentration: 1.0
is: CHEBI:28997
is: C05512

http://identifiers.org/biomodels.db/MODEL1310110002#_ce2661d9_cfd2_4c18_aaab_c50ccb627e9e
type: Species
is: Q03393
is encoded by: hsa:5805
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
name: PTS

metaM thbpt c
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB00027
name: 5,6,7,8-tetrahydrobiopterin
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:15372
initial concentration: 1.0

metaR AG13T8g
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
fast: false
reversible: false
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110002#_4835939c_572d_44b7_bd15_2ecd367a2552
is encoded by: hsa:4704
constant: false
name: NDUFA9
initial concentration: NaN
is: Q16795
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species

metaR r1116
kinetic law: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
reversible: true
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
product: MODEL1310110002#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_c181e675_e08b_4711_b249_027bb85d42d6
boundary condition: true
name: ACSL5
is encoded by: hsa:51703
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is: Q9ULC5
is: SBO:0000252
type: Species

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR r2125
reactant: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110002#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185

metaM akg m
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
boundary condition: false
is: SBO:0000247
name: 2-Oxoglutarate
is: C00026
has only substance units: false
type: Species
is: HMDB00208
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16810
constant: false

metaR 3DSPHR
product: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.102
notes: GENE_ASSOCIATION: (2531.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 1.1.1.102 Confidence Level: 4 AUTHORS: NOTES:
name: 3-Dehydrosphinganine reductase
modifier: MODEL1310110002#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110002#
type: Reaction
reversible: false

metaR PPItx
is described by: ECO:0000000
kinetic law: MODEL1310110002#
name: Diphosphate transporter, peroxisome
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
fast: false

metaR UMPK7
reactant: MODEL1310110002#
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (dGTP)
is: SBO:0000176
type: Reaction
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_8469b633_80c0_4a13_831c_303521e9c7b5
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
name: GMPR2
initial concentration: NaN
is encoded by: hsa:51292
has only substance units: false
boundary condition: true
is: Q9P2T1

metaM sphs1p c
initial amount: NaN
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false
type: Species
is: CHEBI:60119
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00277
name: sphingosine 1-phosphate(1-)
initial concentration: 1.0

metaM ksii core4 pre10 g
initial amount: NaN
constant: false
is: CHEBI:28067
boundary condition: false
notes: FORMULA: C89H143N7O69S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 10
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_497e10de_438e_4145_9d07_971194bcd2af
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: DGKZ
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: B7Z2M9
is encoded by: hsa:8525

http://identifiers.org/biomodels.db/MODEL1310110002#_593acdd4_09c5_47d6_9af1_9936be6b64a8
is encoded by: hsa:229
has only substance units: false
is: P05062
constant: false
name: ALDOB
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaM HC02210 e
type: Species
initial concentration: 1.0
constant: false
name: prostaglandin-d3
has only substance units: false
is: CHEBI:34939
is: SBO:0000247
boundary condition: false
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-18,21-22H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN

metaR GGH 7THFe
reversible: false
reactant: MODEL1310110002#
type: Reaction
fast: false
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110002#
name: Gamma-glutamyl hydrolase (7THF), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110002#_metaR_GALGALFUCFUCGALACGLCGALACGLCGAL14ACGLCGALGLUSIDEte
kinetic law: MODEL1310110002#
reversible: true
is described by: ECO:0000000
fast: false
product: MODEL1310110002#
is: SBO:0000185
name: blood group intracellular transport
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_e29ea1d7_97ea_41af_bbba_5aeda54ab466
initial amount: NaN
is encoded by: hsa:2821
has only substance units: false
type: Species
is: SBO:0000252
constant: false
name: GPI
initial concentration: NaN
boundary condition: true
is: P06744

http://identifiers.org/biomodels.db/MODEL1310110002#_e60465a9_5999_42d1_9637_c21455405be7
name: TXNRD1
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:7296
boundary condition: true

metaR r1117
reversible: true
fast: false
type: Reaction
name: Facilitated diffusion
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
product: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_d13a51cd_be68_47a7_85f9_557828dca3cb
name: NME6
is encoded by: hsa:10201
is: O75414
has only substance units: false
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_4211ec07_f152_4e3f_9ae0_66277ad6ee2d
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
is: P16260
type: Species
initial amount: NaN
is encoded by: hsa:8034
name: SLC25A16
initial concentration: NaN

metaR EX pyr LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Pyruvate exchange
type: Reaction

metaR GAO1g
kinetic law: MODEL1310110002#
name: Ganglioside O-acetylation
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000269
reactant: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction

metaM hdca r
constant: false
initial concentration: 1.0
name: Hexadecanoate (n-C16:0)
is: SBO:0000247
has only substance units: false
is: CHEBI:7896
is: HMDB00220
is: C00249
boundary condition: false
initial amount: NaN
notes: FORMULA: C16H31O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
type: Species

metaM ksi pre4 g
name: keratan sulfate I biosynthesis, precursor 4
is: HMDB00175
type: Species
has only substance units: false
is: C00130
notes: FORMULA: C101H165N7O72X CHARGE: -1
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:58053
initial amount: NaN
boundary condition: false

metaR CREATt4 2 r
fast: false
name: Creatine transport (sodium symport) (2:1)
is: SBO:0000185
reactant: MODEL1310110002#
reversible: true
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (6535.1) or (386757.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_e0ffc450_7e43_41dd_b961_aacfe701c66c
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4717
constant: false
has only substance units: false
name: NDUFC1
is: O43677

metaR r1706
fast: false
product: MODEL1310110002#
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaR ACGAM6PSi
is described by: ECO:0000304
type: Reaction
is: SBO:0000176
fast: false
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.4
notes: GENE_ASSOCIATION: (64841.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.3.1.4 Confidence Level: 2 AUTHORS: NOTES:NCD
name: N-acetylglucosamine-6-phosphate synthase
reactant: MODEL1310110002#
product: MODEL1310110002#
modifier: MODEL1310110002#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110002#_43f68bd6_8a4b_45ca_8546_3a2d01f9faee
name: CHAT
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is: Q6LEN5
initial concentration: NaN
constant: false
is encoded by: hsa:1103
has only substance units: false

metaR GLYCLTtp
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD
reversible: false
is described by: ECO:0000000
fast: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
name: glycolate transport into peroxisome

http://identifiers.org/biomodels.db/MODEL1310110002#_565ee09b_2677_4800_99e3_0e31ca6ffd8f
is: SBO:0000252
is encoded by: hsa:10682
is: Q15125
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: EBP
constant: false
type: Species
boundary condition: true

metaM m5mpdol U r
initial concentration: 1.0
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20
type: Species
initial amount: NaN
constant: false
is: CHEBI:37634
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_15bdcef7_ad33_4c92_b55a_7d1e85ab17cb
is encoded by: hsa:65263
is: SBO:0000252
name: PYCRL
initial concentration: NaN
initial amount: NaN
is: Q53H96
constant: false
has only substance units: false
type: Species
boundary condition: true

metaM dcdp m
type: Species
is: HMDB01245
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: SBO:0000247
is: CHEBI:58593
name: dCDP(3-)
initial concentration: 1.0
constant: false

metaR BAMPPALDOX
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
is described by: ECO:0000212
is version of: http://identifiers.org/ec-code/1.2.1.36
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
fast: false
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110002#_75397e26_7961_4a0f_b5f3_80780e338a02
boundary condition: true
initial concentration: NaN
has only substance units: false
name: ETFA
is encoded by: hsa:2108
initial amount: NaN
is: SBO:0000252
is: P13804
constant: false
type: Species

metaR EX adn LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Adenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_3d205941_d973_4667_b1eb_ae742921f02d
constant: false
name: QDPR
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is: P09417
is: SBO:0000252
is encoded by: hsa:5860
initial concentration: NaN

metaM cholcoa c
constant: false
notes: FORMULA: C45H70N7O20P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O20P3S/c1-23(26-7-8-27-34-28(18-31(55)45(26,27)5)44(4)12-10-25(53)16-24(44)17-29(34)54)6-9-33(57)76-15-14-47-32(56)11-13-48-41(60)38(59)43(2,3)20-69-75(66,67)72-74(64,65)68-19-30-37(71-73(61,62)63)36(58)42(70-30)52-22-51-35-39(46)49-21-50-40(35)52/h21-31,34,36-38,42,53-55,58-59H,6-20H2,1-5H3,(H,47,56)(H,48,60)(H,64,65)(H,66,67)(H2,46,49,50)(H2,61,62,63)/p-4/t23-,24+,25-,26-,27+,28+,29-,30-,31+,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00844 EHMN_ABBREVIATION: C01794
initial concentration: 1.0
name: choloyl-CoA(4-)
is: CHEBI:57373
is: HMDB01374
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247

metaR MG2er
reversible: false
is: SBO:0000176
reactant: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_d22161ec_ce2a_46a4_9048_b90055f4b242
constant: false
has only substance units: false
is: SBO:0000252
is: Q92947
type: Species
is encoded by: hsa:2639
boundary condition: true
initial concentration: NaN
name: GCDH
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_45c4353b_8927_432b_a2e6_17741e779322
has only substance units: false
type: Species
is encoded by: hsa:1103
initial concentration: NaN
is: D3DX95
name: CHAT
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

metaR A4GALTg
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (53947.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.228 Confidence Level: 4 AUTHORS: PMID:10747952,PMID:10748143 NOTES:EC: 2.4.1.228 NJ
reversible: false
reactant: MODEL1310110002#
is described by: ECO:0000269
name: Lactosylceramide 4-alpha-galactosyltransferase
product: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.228
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#

metaM 2dodtricoa m
is: SBO:0000247
is: HMDB03952
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 2,6,9-dodecatrienoylcoa
type: Species
constant: false
is: C05280
initial amount: NaN
notes: FORMULA: C33H48N7O17P3S CHARGE: -4

metaM CE5786 e
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: kinetensin
is: HMDB02710
has only substance units: false
is: CHEBI:27485
notes: FORMULA: C56H87N17O11 CHARGE: 2 INCHI: InChI=1/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/p+2/t32-,33+,38-,39+,40-,41+,42-,43+,44-,45-/m1/s1 EHMN_ABBREVIATION: CE5786
initial amount: NaN
boundary condition: false

metaR r1559
fast: false
product: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110002#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110002#
type: Reaction

metaR DM atp c
is: SBO:0000176
reversible: false
product: MODEL1310110002#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
name: DM_atp(c)

http://identifiers.org/biomodels.db/MODEL1310110002#_7c3726dc_7786_48a8_9e4f_6a373ffa8d26
initial amount: NaN
is encoded by: hsa:978
has only substance units: false
is: P32320
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
name: CDA
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_51d09594_d406_4940_8fbe_c77c858a8e57
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is: P04035
name: HMGCR
type: Species
is encoded by: hsa:3156
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_c5b2b20a_0d94_4ae5_84ae_12f5d459f37f
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: Q8N5Z0
name: AADAT
boundary condition: true
is encoded by: hsa:51166

http://identifiers.org/biomodels.db/MODEL1310110002#_22c5b091_e0a1_4e8c_a218_fcac370d809e
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:1609
type: Species
is: P52824
initial amount: NaN
name: DGKQ

http://identifiers.org/biomodels.db/MODEL1310110002#_bd71efae_5d7b_4d52_ab13_659d1c36fd73
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
type: Species
name: _AI694761_1_c
initial concentration: NaN
is encoded by: hsa:AI694761

metaR r0437
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
is: SBO:0000176
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/4.1.2.13
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110002#

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaM sphs1p e
is: HMDB00277
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
constant: false
is: CHEBI:60119
name: sphingosine 1-phosphate(1-)
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_79503b89_55ca_43c8_b40e_6b1909d4925f
has only substance units: false
name: PLD1
type: Species
constant: false
is: SBO:0000252
is: Q59EA4
initial amount: NaN
boundary condition: true
is encoded by: hsa:5337
initial concentration: NaN

metaR PPItr
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110002#
fast: false
reversible: true
product: MODEL1310110002#
name: Diphosphate transporter, endoplasmic reticulum
kinetic law: MODEL1310110002#

metaM val L e
name: L-valine
initial amount: NaN
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
constant: false
has only substance units: false
boundary condition: false
is: CHEBI:16414
is: SBO:0000247
is: HMDB00883
type: Species
initial concentration: 1.0

metaM glyald m
is: CHEBI:17378
initial amount: NaN
has only substance units: false
is: HMDB01051
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: SBO:0000247
boundary condition: false
name: D-glyceraldehyde

metaR 3SALAASPm
type: Reaction
fast: false
name: cysteinesulfinate-aspartate mitochondrial shuttle
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
is described by: ECO:0000304
is: SBO:0000185
reversible: true
modifier: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#

metaM cit m
boundary condition: false
is: CHEBI:16947
name: Citrate
is: SBO:0000247
initial amount: NaN
is: HMDB00094
has only substance units: false
is: C00158
type: Species
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_ef3b6036_73d7_4e72_809f_4ee262e90bc8
is encoded by: hsa:1737
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q86YI5
type: Species
constant: false
name: DLAT
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_a3fd3153_33a7_4d65_aaf4_e41cb9680bdd
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:7296
is: SBO:0000252
has only substance units: false
name: TXNRD1
boundary condition: true

metaM spc hs c
type: Species
name: sphingosylphosphorylcholine
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C23H50N2O5P CHARGE: 1 INCHI: InChI=1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m1/s1
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5311445

metaR r2128
fast: false
type: Reaction
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110002#
modifier: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110002#
reversible: true
is: SBO:0000185
is described by: ECO:0000000

metaM man g
name: D-mannose
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
has only substance units: false
initial concentration: 1.0
is: CHEBI:16024
is: HMDB00169
boundary condition: false

metaR APOCFm
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110002#
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:IT faked reaction to balance reaction in human biotin metabolism
name: Apocarboxylase formation, mitochondrial
type: Reaction
kinetic law: MODEL1310110002#
reversible: false

metaR FMNAT
modifier: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
type: Reaction
fast: false
name: FMN adenylyltransferase
reactant: MODEL1310110002#
reversible: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (80308.1) or (80308.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 2.7.7.2 Confidence Level: 2 AUTHORS: PMID:16643857,PMID:17049878 NOTES:Human Y/N: Y
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.7.2

metaM s2l2fn2m2masn e
name: PA6
is: C00255
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: HMDB00244
initial amount: NaN
is: CHEBI:3554

http://identifiers.org/biomodels.db/MODEL1310110002#_0c9aea66_2784_4281_a168_d0a8ee3d8a4d
type: Species
is: Q14642
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: INPP5A
boundary condition: true
constant: false
is encoded by: hsa:3632

metaR M16NTg
product: MODEL1310110002#
type: Reaction
fast: false
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (4247.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.143 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.143
modifier: MODEL1310110002#
is described by: ECO:0000000
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
kinetic law: MODEL1310110002#

metaR r1556
product: MODEL1310110002#
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

metaR GGH 6THFe
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.4.19.9
reversible: false
name: Gamma-glutamyl hydrolase (6THF), extracellular
is: SBO:0000176
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
fast: false

metaM andrstandn r
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
has only substance units: false
name: 5alpha-androstane-3,17-dione
is: CHEBI:15994
boundary condition: false
is: HMDB00899

metaR UGLT
type: Reaction
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
product: MODEL1310110002#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.12
is described by: ECO:0000000
kinetic law: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
name: UDPglucose--hexose-1-phosphate uridylyltransferase
modifier: MODEL1310110002#
is: SBO:0000176

metaR GBSIDEtl
name: globoside intracellular transport
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) NJ
fast: false

metaR EX tchola LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurocholic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_metaR_EX_s2l2fn2m2masn_LPAREN_e_RPAREN_
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: PA6 exchange
type: Reaction

metaR Asn X Ser Thrtr
reactant: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
type: Reaction
product: MODEL1310110002#
fast: false
reversible: true
is described by: ECO:0000269
name: Asn-X-Ser/Thr transport (from ER to lysosome)
kinetic law: MODEL1310110002#

metaR RE3001M
name: RE3001
reactant: MODEL1310110002#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.34
modifier: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
type: Reaction
fast: false

metaM fuc1p L c
boundary condition: false
is: CHEBI:28319
is: HMDB01265
constant: false
initial amount: NaN
type: Species
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
initial concentration: 1.0
name: L-Fucose 1-phosphate
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_2c67a71b_e4a0_4c44_b9d6_7682498b65cd
is encoded by: hsa:R51273
is: SBO:0000252
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: _R51273_1_c
has only substance units: false
boundary condition: true

metaM ksii core2 pre5 g
is: CHEBI:58053
notes: FORMULA: C61H99N5O43X CHARGE: -1
name: keratan sulfate II biosynthesis, precursor 5
is: C00130
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00175
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_5f256305_6a09_42d2_93c6_c504ef62628b
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
is: Q969I6
name: SLC38A4
constant: false
is encoded by: hsa:55089
initial concentration: NaN

metaR LPS3
name: lipase
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) SUBSYSTEM: Triacylglycerol synthesis EC Number: 3.1.1.23 Confidence Level: 4 AUTHORS: PMID:9495531 NOTES:NJ
type: Reaction
is: SBO:0000176
fast: false
reversible: false
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.1.1.23
product: MODEL1310110002#
is described by: ECO:0000000

metaM prostge1 c
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:57397
type: Species
is: HMDB01442
name: prostaglandin E1(1-)
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/p-1/b13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C04741

metaR r1008
fast: false
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
is described by: ECO:0000000
product: MODEL1310110002#
type: Reaction
name: Facilitated diffusion
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_d29f05e6_1208_4b77_a7bb_39d7f7a9df28
name: SDHD
has only substance units: false
type: Species
is encoded by: hsa:6392
initial amount: NaN
boundary condition: true
is: O14521
initial concentration: NaN
constant: false
is: SBO:0000252

metaR r2129
modifier: MODEL1310110002#
reversible: true
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110002#
type: Reaction
is: SBO:0000185

metaM cspg e l
boundary condition: false
initial amount: NaN
is: HMDB00062
constant: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
has only substance units: false
is: C00318
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: SBO:0000247
is: CHEBI:16347
type: Species
initial concentration: 1.0

metaM m8masn r
constant: false
initial concentration: 1.0
is: C05876
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C70H117N2O55X CHARGE: 0

metaM bildglcur e
constant: false
type: Species
is: CHEBI:58471
name: bis(beta-glucosyluronate)bilirubin
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
is: HMDB03325
boundary condition: false

metaR CHOLtu
reversible: true
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
name: Choline uniport
product: MODEL1310110002#
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000269
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_9ab0aba5_75f5_46fa_9139_f60d0bc25227
is: P49327
is encoded by: hsa:2194
name: FASN
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
type: Species

metaR r1557
is described by: ECO:0000000
reactant: MODEL1310110002#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110002#
product: MODEL1310110002#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

metaM aacoa m
is: HMDB01484
initial concentration: 1.0
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
constant: false
has only substance units: false
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:57286
initial amount: NaN
name: acetoacetyl-CoA(4-)

metaR CYTK1n
product: MODEL1310110002#
is: SBO:0000176
reactant: MODEL1310110002#
is described by: ECO:0000269
fast: false
type: Reaction
name: cytidylate kinase (CMP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110002#_dd87a3a2_5ca5_4e82_955b_d7c7ecf64cd0
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:AI653169
constant: false
is: SBO:0000252
initial amount: NaN
name: _AI653169_1_c
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_910c17cf_789c_4844_bbdd_1d2ca2993fa0
is encoded by: hsa:5295
initial concentration: NaN
name: PIK3R1
is: SBO:0000252
is: P27986
has only substance units: false
constant: false
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_ffe613e9_edca_4bdb_996a_8ad20227a3b0
type: Species
boundary condition: true
name: HLCS
initial concentration: NaN
initial amount: NaN
is: P50747
constant: false
is: SBO:0000252
is encoded by: hsa:3141
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_c544e4ae_b00d_43c1_8e83_22cc4ade329b
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q8IUC8
constant: false
is encoded by: hsa:114805
is: SBO:0000252
type: Species
name: GALNT13

metaR GALASE17ly
name: beta-galactosidase, lysosomal
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.1.6.4
type: Reaction
fast: false
modifier: MODEL1310110002#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.23

metaR r0434
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110002#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
fast: false
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_68e565e3_068c_478d_bac1_92023f44b2d8
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AL038231
type: Species
name: _AL038231_1_c
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false

metaR CHOLtr
is: SBO:0000185
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
name: choline intracellular transport
product: MODEL1310110002#

metaR ASPDTDe
is described by: ECO:0000134
is: SBO:0000185
name: D-aspartate transport, extracellular
reversible: true
type: Reaction
fast: false
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: D-aspartate may exit by diffusion or require specific transporters. NOTES:D-aspartate may exit by diffusion or require specific transporters.

http://identifiers.org/biomodels.db/MODEL1310110002#_19189163_a415_4f37_9574_bb7b186d1857
is encoded by: hsa:91703
name: ACY3
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
is: Q96HD9
is: SBO:0000252
type: Species
boundary condition: true

metaR G14T11g
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
product: MODEL1310110002#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
modifier: MODEL1310110002#
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_54c2d83f_13a6_4079_a045_d5df822581bc
is encoded by: hsa:8801
boundary condition: true
name: SUCLG2
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: Q96I99
is: SBO:0000252

metaM arachcoa m
is: SBO:0000247
initial concentration: 1.0
constant: false
name: arachidyl coenzyme A
type: Species
is: HMDB04258
initial amount: NaN
boundary condition: false
is: CHEBI:15527
has only substance units: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041

metaM occoa x
is: CHEBI:57386
name: Octanoyl-CoA (n-C8:0CoA)
constant: false
boundary condition: false
is: C01944
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB01070
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_60595a22_51f9_4b35_b7c6_25ec3bd9291a
initial concentration: NaN
boundary condition: true
is: A6NDW6
is: SBO:0000252
is encoded by: hsa:79053
type: Species
name: ALG8
constant: false
has only substance units: false
initial amount: NaN

metaM n2m2mn l
type: Species
is: CHEBI:16680
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
notes: FORMULA: C42H71N3O31 CHARGE: 0
is: SBO:0000247
is: HMDB00939
boundary condition: false

metaR FAOXC102C103m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaM bildglcur c
name: bis(beta-glucosyluronate)bilirubin
constant: false
has only substance units: false
is: CHEBI:58471
initial concentration: 1.0
type: Species
notes: FORMULA: C45H50N4O18 CHARGE: -2 INCHI: InChI=1S/C45H52N4O18/c1-7-20-19(6)40(58)49-27(20)14-25-18(5)23(10-12-31(51)65-45-37(57)33(53)35(55)39(67-45)43(62)63)29(47-25)15-28-22(17(4)24(46-28)13-26-16(3)21(8-2)41(59)48-26)9-11-30(50)64-44-36(56)32(52)34(54)38(66-44)42(60)61/h7-8,13-14,32-39,44-47,52-57H,1-2,9-12,15H2,3-6H3,(H,48,59)(H,49,58)(H,60,61)(H,62,63)/p-2/b26-13+,27-14+/t32-,33-,34-,35-,36+,37+,38-,39-,44+,45+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01616 EHMN_ABBREVIATION: C05787
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB03325

metaR PI5P3K
reactant: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.1.153
reversible: false
name: phosphatidylinositol-5-phosphate 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.154
type: Reaction
fast: false
modifier: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.11.1

http://identifiers.org/biomodels.db/MODEL1310110002#_eb495265_cb0e_45b4_a075_b56114f53859
has only substance units: false
type: Species
name: FUT9
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10690
is: Q9Y231

metaM acetol c
is: HMDB06961
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:27957
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
constant: false
name: hydroxyacetone
initial concentration: 1.0

metaR PPItm
name: diphopshate transporter, mitochondrial
is: SBO:0000185
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
product: MODEL1310110002#
is described by: ECO:0000134
reversible: true
type: Reaction
kinetic law: MODEL1310110002#

metaM Rtotal2 e
initial amount: NaN
is: CHEBI:3554
is: HMDB00244
has only substance units: false
initial concentration: 1.0
notes: FORMULA: CO2FULLR2 CHARGE: -1
constant: false
type: Species
boundary condition: false
is: SBO:0000247
is: C00255
name: R total 2 position

metaR NAHCO3 HCLt
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (9498.1) or (57282.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
is described by: ECO:0000269
name: bicarbonate transport (HCl/NaHCO3 exchange)
product: MODEL1310110002#

metaR r2198
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110002#
reactant: MODEL1310110002#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
is described by: ECO:0000000
kinetic law: MODEL1310110002#
type: Reaction
fast: false
modifier: MODEL1310110002#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_d258380d_b085_4910_938c_6fa75e094674
is encoded by: hsa:3284
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P26439
initial amount: NaN
constant: false
name: HSD3B2

http://identifiers.org/biomodels.db/MODEL1310110002#_54b53044_5145_40f6_b336_ab42a43e1aa6
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:622
boundary condition: true
constant: false
name: BDH1
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_e036f2c7_0100_42b2_9018_4ca41c811165
constant: false
name: LDHC
initial concentration: NaN
is: P07864
is: SBO:0000252
is encoded by: hsa:3948
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_7eafd194_6aea_4351_9b4b_b949da059ab2
type: Species
initial amount: NaN
name: PCBD1
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5092

metaM HC01602 c
is: SBO:0000247
has only substance units: false
name: 10-Formyltetrahydrofolate
initial amount: NaN
constant: false
is: C00234
type: Species
is: CHEBI:57454
boundary condition: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial concentration: 1.0

metaM akg c
is: HMDB00208
initial concentration: 1.0
is: SBO:0000247
is: C00026
initial amount: NaN
constant: false
name: 2-Oxoglutarate
has only substance units: false
is: CHEBI:16810
boundary condition: false
notes: FORMULA: C5H4O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_87b51fff_0b77_4bb5_b5e4_5f068e9c5ae6
is encoded by: hsa:5315
has only substance units: false
initial amount: NaN
name: PKM2
constant: false
is: P14618
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM pail345p hs c
boundary condition: false
initial amount: NaN
is: CHEBI:57836
is: SBO:0000247
notes: FORMULA: C9H13O18P4FULLRCO2FULLR2CO2 CHARGE: -7 EHMN_ABBREVIATION: C05981
type: Species
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_e174d6cf_a2fc_482e_b32a_bfe2677b9b0c
has only substance units: false
initial amount: NaN
is: SBO:0000252
name: _AI915649_1_c
type: Species
constant: false
is encoded by: hsa:AI915649
boundary condition: true
initial concentration: NaN

metaR RE2814R
reversible: true
product: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
name: RE2814
type: Reaction
fast: false
is: SBO:0000176

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM core6 l
boundary condition: false
name: Core 6
notes: FORMULA: C16H27N2O10X CHARGE: 0
initial amount: NaN
is: HMDB00143
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:12936
type: Species
has only substance units: false

metaR M8MASNterg
fast: false
name: m8masn transport from ER to Golgi apparatus
reactant: MODEL1310110002#
reversible: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:11007802 NOTES:NCD

metaM man c
constant: false
boundary condition: false
is: C00159
type: Species
name: D-Mannose
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
is: CHEBI:16024
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB00169

metaM n2m2masn g
has only substance units: false
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C50H83N4O35X CHARGE: 0
is: SBO:0000247
initial amount: NaN
is: C11530
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)

metaR FAOXC121C10x
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C12:1-->C10)x
type: Reaction

metaR ADCim
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
kinetic law: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
reversible: false
reactant: MODEL1310110002#
fast: false
name: Acetoacetate decarboxylation (irreversible), mitochondrial

http://identifiers.org/biomodels.db/MODEL1310110002#_bd95a898_3100_40ab_b5f3_1f0a216963cb
is: SBO:0000252
initial amount: NaN
type: Species
is: O00459
name: PIK3R2
has only substance units: false
is encoded by: hsa:5296
boundary condition: true
initial concentration: NaN
constant: false

metaR Htg
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
reversible: true
fast: false
name: proton diffusion (Golgi)
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185

metaR EX Rtotal LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total exchange
type: Reaction

metaM hexe3coa m
is: HMDB06522
initial concentration: 1.0
type: Species
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
name: 3-hexenoylcoa
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247

metaR r0604
modifier: MODEL1310110002#
is: SBO:0000176
reactant: MODEL1310110002#
type: Reaction
reversible: false
name: (S)-2-methylbutanoyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-(2-methylbutanoyl)transferase Valine, leucine and isoleucine degradation EC:2.3.1.168
fast: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.168 Confidence Level: 0 AUTHORS: PMID:1943690 NOTES:
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_4d06766e_be04_40f1_9c10_ae012ec73bcd
is: Q02338
boundary condition: true
initial amount: NaN
is encoded by: hsa:622
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: BDH1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_37c8c7ca_38b4_41d9_9d16_bf268a931503
has only substance units: false
constant: false
initial concentration: NaN
is: P20674
initial amount: NaN
type: Species
is encoded by: hsa:9377
boundary condition: true
is: SBO:0000252
name: COX5A

http://identifiers.org/biomodels.db/MODEL1310110002#_1bb2084c_c2d3_4b01_a13b_6d9fa5111f2f
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
name: _C7orf24_1_m
is encoded by: hsa:C7orf24
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_1c0dd9aa_fd30_4b22_aa41_83b6e8e63b95
name: GALNT12
boundary condition: true
is: Q8IXK2
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:79695
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_342dd5bb_85fc_4d46_8676_0adc9223de47
initial concentration: NaN
has only substance units: false
is encoded by: hsa:84890
is: B3KXN9
constant: false
type: Species
name: ADO
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_7b322894_16b5_45e5_abf2_8f829c99817f
is: E7EPT3
type: Species
has only substance units: false
is: SBO:0000252
name: ALDH7A1
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:501

metaM HC02217 c
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: prostaglandin-g2
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
constant: false
is: CHEBI:27647
has only substance units: false
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_4d7da70e_92d2_4483_b905_554f1ad74371
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: PC
is encoded by: hsa:5091
type: Species
has only substance units: false
constant: false

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_a1f12095_0c0f_43b7_b4e4_2578c7b76107
initial concentration: NaN
is encoded by: hsa:8560
is: SBO:0000252
type: Species
has only substance units: false
boundary condition: true
constant: false
name: DEGS1
initial amount: NaN

metaR r0603
notes: GENE_ASSOCIATION: (AW299740.1) or (1737.1) or (J03866.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 0 AUTHORS: PMID:6401712 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110002#
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110002#
reversible: true
name: (S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase Valine, leucine and isoleucine degradation EC:1.3.99.12
product: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.12

metaR r2196
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_28b789fe_2283_461b_9f78_033442c433ca
has only substance units: false
name: ST3GAL3
is: SBO:0000252
is encoded by: hsa:6487
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM cs d deg4 l
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00127
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 4
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15748
notes: FORMULA: C31H47NO35S3 CHARGE: -4
boundary condition: false

metaM akg e
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:16810
notes: FORMULA: C5H4O5 CHARGE: -2 INCHI: InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)/p-2 HEPATONET_1.0_ABBREVIATION: HC00035 EHMN_ABBREVIATION: C00026
name: 2-oxoglutarate(2-)
has only substance units: false
boundary condition: false
type: Species
is: HMDB00208
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_bfd76129_1ee9_42a3_afe3_23f9e99cdb87
boundary condition: true
name: ALDH1A3
has only substance units: false
is encoded by: hsa:220
is: P47895
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN

metaM dgdp c
has only substance units: false
type: Species
constant: false
is: HMDB00960
name: dGDP
initial amount: NaN
boundary condition: false
is: CHEBI:58595
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
initial concentration: 1.0
is: C00361

metaM val L c
is: HMDB00883
is: CHEBI:16414
initial amount: NaN
boundary condition: false
name: L-valine
initial concentration: 1.0
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
type: Species
has only substance units: false
constant: false
is: SBO:0000247

metaM strdnc c
initial concentration: 1.0
has only substance units: false
name: stearidonic acid C18:4, n-3
is: C16300
notes: FORMULA: C18H27O2 CHARGE: -1 INCHI: InChI=1/C18H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10,12-13H,2,5,8,11,14-17H2,1H3,(H,19,20)/b4-3-,7-6-,10-9-,13-12- HEPATONET_1.0_ABBREVIATION: HC00793
boundary condition: false
constant: false
is: HMDB06547
type: Species
is: SBO:0000247
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205608

metaM 5thf e
has only substance units: false
is: HMDB06487
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
name: pentaglutamyl folate (THF)
notes: FORMULA: C39H45N11O18 CHARGE: -6
constant: false
type: Species

metaR r1563
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#

metaM cspg e e
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
boundary condition: false
type: Species
is: HMDB00630
is: CHEBI:16040
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
has only substance units: false

metaM inost c
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: myo-inositol
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:17268
is: HMDB00211
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_e11f0cbc_f87c_4742_9acf_24a07ed3e2c0
initial amount: NaN
constant: false
is encoded by: hsa:1103
name: CHAT
boundary condition: true
is: Q6LEN6
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_49711fb7_4ba2_4349_b286_6be0672fcff1
has only substance units: false
boundary condition: true
initial concentration: NaN
name: ME2
is encoded by: hsa:4200
constant: false
is: P23368
initial amount: NaN
is: SBO:0000252
type: Species

metaR r0688
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110002#
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
modifier: MODEL1310110002#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110002#_583d6263_e9f3_42fa_9446_0bb96ec3e5e4
initial amount: NaN
constant: false
initial concentration: NaN
is: P38117
boundary condition: true
name: ETFB
is encoded by: hsa:2109
is: SBO:0000252
type: Species
has only substance units: false

metaR ACONTm
name: Aconitate hydratase
notes: GENE_ASSOCIATION: (50.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:IF. Biochemical
is described by: ECO:0000134
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
fast: false
reversible: true
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/4.2.1.3

metaM odecoa m
boundary condition: false
constant: false
is: HMDB01322
type: Species
name: Octadecenoyl-CoA (n-C18:1CoA)
is: CHEBI:57387
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00400 EHMN_ABBREVIATION: C00510
has only substance units: false
initial concentration: 1.0

metaR ALR3
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
type: Reaction
name: aldose reductase (acetol)
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: false
modifier: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.21

http://identifiers.org/biomodels.db/MODEL1310110002#_ae180523_f786_49b5_8cc0_e5f3411e060e
name: SLC24A2
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:25769
boundary condition: true
is: Q9UI40
constant: false
initial concentration: NaN
type: Species

metaM 2hexdtetcoa m
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
constant: false
is: SBO:0000247
has only substance units: false
name: 2,7,10,13-hexadecatetraenoylcoa
boundary condition: false
is: HMDB02288
initial concentration: 1.0
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_38418c0e_0702_4859_ab47_7bdab710f47b
initial concentration: NaN
is encoded by: hsa:U52111
name: _U52111_1_c
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_acglc13galacglcgal14acglcgalgluside_hs_g
name: nLc7Cer
initial concentration: 1.0
is: CHEBI:26174
has only substance units: false
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false

metaM HC02187 c
constant: false
name: reverse-triiodthyronine
type: Species
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial amount: NaN
has only substance units: false
is: CHEBI:28774
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR ACOAD1fm
product: MODEL1310110002#
reversible: false
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
is described by: ECO:0000269
fast: false
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_4b8e4ee1_7766_4d64_9bc5_a087741ad784
constant: false
type: Species
is: E9KL44
is encoded by: hsa:3030
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: HADHA
initial concentration: NaN

metaM amet m
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: CHEBI:15414
is: HMDB01185
name: S-Adenosyl-L-methionine
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: C00019
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaR CSPG Etly
product: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
name: chondroitin sulfate E transport, extracellular to lysosome
type: Reaction
fast: false
kinetic law: MODEL1310110002#
reversible: false
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_16f8d975_c2b7_4e49_a380_a1e6d018ee0f
initial concentration: NaN
name: AK5
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: Q9Y6K8
is encoded by: hsa:26289
constant: false
type: Species

metaR ARACHCPT2
name: carnitine transferase
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110002#
reversible: false
reactant: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110002#
is described by: ECO:0000000
modifier: MODEL1310110002#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110002#_525c0ccc_219e_4503_a98b_5cef849b6742
initial concentration: NaN
is: SBO:0000297
name: NME1:NME2
constant: false
has only substance units: false
type: Species
is encoded by: hsa:4830
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_4efacb6a_f053_4609_9ad6_dd4af96b1f6e
type: Species
boundary condition: true
constant: false
is: A0PJJ9
is encoded by: hsa:2686
initial amount: NaN
is: SBO:0000252
name: GGT7
initial concentration: NaN
has only substance units: false

metaR r1562
product: MODEL1310110002#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_73cb35c9_25ce_4d88_ab44_a10091b27971
is: E9PAY8
name: PPAP2C
has only substance units: false
constant: false
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8612

metaM cit c
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
name: Citrate
is: HMDB00094
is: CHEBI:16947
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
is: C00158

metaM dtmp m
name: dTMP
is: HMDB01227
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
type: Species
is: C00364
has only substance units: false
boundary condition: false
is: CHEBI:26999

http://identifiers.org/biomodels.db/MODEL1310110002#_91593381_43b7_476f_8715_36f0437533ae
is: SBO:0000252
initial amount: NaN
constant: false
is: B4DK61
boundary condition: true
is encoded by: hsa:51
has only substance units: false
name: ACOX1
type: Species
initial concentration: NaN

metaM ribflv c
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: C00255
is: HMDB00244
has only substance units: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
name: Riboflavin
constant: false
is: SBO:0000247
is: CHEBI:3554

metaM thyox L c
initial amount: NaN
is: HMDB00248
name: L-thyroxine
boundary condition: false
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
has only substance units: false
type: Species
constant: false
is: CHEBI:18332
is: SBO:0000247
initial concentration: 1.0

metaR SIAASE4ly
name: sialidase, lysosomal
is described by: ECO:0000000
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
type: Reaction

metaM estradiol r
initial concentration: 1.0
type: Species
notes: FORMULA: C18H24O2 CHARGE: 0 INCHI: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1 EHMN_ABBREVIATION: C00951
boundary condition: false
is: HMDB00151
is: CHEBI:16469
constant: false
is: SBO:0000247
has only substance units: false
name: estradiol
initial amount: NaN

metaR LYStip
kinetic law: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:6811962 NOTES:MM
reactant: MODEL1310110002#
fast: false
type: Reaction
name: L-lysine transport, peroxisomal (irreversible)

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaM gsn c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:16750
constant: false
is: SBO:0000247
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: HMDB00133
is: C00387
type: Species
name: Guanosine
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_daf803ab_4ead_40ef_a1af_28433b16135b
boundary condition: true
constant: false
is encoded by: hsa:51102
is: SBO:0000252
type: Species
initial concentration: NaN
name: MECR
initial amount: NaN
has only substance units: false
is: Q9BV79

metaR HSD3A1r
type: Reaction
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.225
product: MODEL1310110002#
reversible: true
is: SBO:0000176
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)

metaR ACCOAtn
type: Reaction
kinetic law: MODEL1310110002#
name: acetyl-CoA transport, nuclear
is: SBO:0000185
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110002#
product: MODEL1310110002#

metaM inost e
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
constant: false
initial concentration: 1.0
initial amount: NaN
name: myo-inositol
is: HMDB00211
is: CHEBI:17268
boundary condition: false
has only substance units: false
type: Species

metaM g2m8mpdol U r
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
is: SBO:0000247
boundary condition: false
is: CHEBI:59093
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaR r1561
type: Reaction
reversible: true
kinetic law: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110002#
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM glyald c
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
constant: false
is: SBO:0000247
type: Species
is: C00577
is: HMDB01051
initial amount: NaN
has only substance units: false
name: D-Glyceraldehyde
is: CHEBI:17378
initial concentration: 1.0
boundary condition: false

metaM abt c
name: L-arabinitol
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: CHEBI:18403
initial amount: NaN
boundary condition: false
is: HMDB01851
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial concentration: 1.0

metaM glx m
initial concentration: 1.0
initial amount: NaN
is: HMDB00119
is: CHEBI:36655
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
constant: false
name: glyoxylate
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048

http://identifiers.org/biomodels.db/MODEL1310110002#_dcb138bb_a782_4712_a8d7_c53ae33bf2aa
is encoded by: hsa:54995
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: OXSM
is: Q9NWU1
type: Species
initial concentration: NaN
has only substance units: false
constant: false

metaM ksi pre19 g
is: C00130
constant: false
has only substance units: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 19
is: CHEBI:58053
is: SBO:0000247
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
type: Species
initial concentration: 1.0
is: HMDB00175
boundary condition: false

metaR r2347
fast: false
type: Reaction
kinetic law: MODEL1310110002#
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110002#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110002#

metaR DOPAt4 2 r
is described by: ECO:0000269
is: SBO:0000185
reversible: true
name: Dopamine reversible transport in via sodium symport (1:2)
fast: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
type: Reaction

metaM b2coa m
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
name: crotonoyl-CoA(4-)
initial amount: NaN
is: CHEBI:57332
boundary condition: false
has only substance units: false
is: SBO:0000247
constant: false
type: Species
is: HMDB02009
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_e41722c3_6887_4d0b_a051_73ae658f1e64
boundary condition: true
initial concentration: NaN
name: NDUFA13
initial amount: NaN
is encoded by: hsa:51079
has only substance units: false
is: SBO:0000252
type: Species
is: Q9P0J0
constant: false

metaM HC02187 e
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:28774
type: Species
name: reverse-triiodthyronine
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_5138b3be_d829_42f6_94dd_31fd521f775c
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:953
is: SBO:0000252
type: Species
is: Q86VV3
initial concentration: NaN
initial amount: NaN
name: ENTPD1

metaR r0686
modifier: MODEL1310110002#
product: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.2.2
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is described by: ECO:0000000
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_412d8068_9f76_4cfc_a165_4ba90a4931d7
is encoded by: hsa:23428
type: Species
has only substance units: false
name: SLC7A8
initial concentration: NaN
constant: false
is: Q86U05
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR r0483
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
reactant: MODEL1310110002#
fast: false
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true

metaR r0752
type: Reaction
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:10424772,PMID:11958479,PMID:3466164 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 3,4-Dihydroxymandelaldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
product: MODEL1310110002#
modifier: MODEL1310110002#
fast: false

metaM lald L c
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m0/s1
is: HMDB03052
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:18041
name: (S)-lactaldehyde

metaR r0074
is version of: http://identifiers.org/ec-code/6.2.1.1
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) SUBSYSTEM: Urea cycle EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
modifier: MODEL1310110002#
is described by: ECO:0000000
reversible: true
fast: false
name: L-Glutamate 5-semialdehyde:NAD+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
is: SBO:0000176
reactant: MODEL1310110002#
product: MODEL1310110002#

metaR r1560
product: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
reactant: MODEL1310110002#

metaM ksii core2 deg8 l
notes: FORMULA: C36H60N3O25X CHARGE: 0
type: Species
name: keratan sulfate II (core 2-linked), degradation product 8
initial concentration: 1.0
is: HMDB00143
has only substance units: false
constant: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:12936
boundary condition: false

metaM CE2421 m
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:30623
is: SBO:0000247
boundary condition: false
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
is: HMDB02329
name: (3S)-3-hydroxylinoleoyl-CoA
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_4d22c914_1b46_4e87_b9e6_96f70122331e
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:6517
constant: false
is: P14672
name: SLC2A4
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_cc76f3f7_e7a0_4135_98ce_d3ef33764428
is: SBO:0000252
constant: false
name: GSR
type: Species
boundary condition: true
is encoded by: hsa:2936
has only substance units: false
is: P00390
initial concentration: NaN
initial amount: NaN

metaM ribflv e
type: Species
is: C00255
constant: false
is: HMDB00244
is: SBO:0000247
has only substance units: false
notes: FORMULA: C17H20N4O6 CHARGE: 0
is: CHEBI:3554
boundary condition: false
name: Riboflavin
initial concentration: 1.0
initial amount: NaN

metaR ALR2
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.21
kinetic law: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
product: MODEL1310110002#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110002#
name: aldose reductase (methylglyoxal)

metaR r2346
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110002#
is: SBO:0000185
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
reversible: true

metaR r0753
is version of: http://identifiers.org/ec-code/2.3.1.85
name: 3,4-Dihydroxymandelaldehyde:NADP+ oxidoreductase Tyrosine metabolism EC:1.2.1.5
fast: false
is described by: ECO:0000000
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.5 Confidence Level: 0 AUTHORS: PMID:11790142,PMID:12604221 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110002#_180e58f4_7107_4ff2_b1ac_c81e6c2b02e4
name: PLCB2
is: Q59F77
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5330
constant: false
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false

metaM cit e
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:16947
name: citrate(3-)
is: HMDB00094
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
type: Species
initial concentration: 1.0
boundary condition: false

metaR HMGCOAtx
reactant: MODEL1310110002#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:diffusion NJ
fast: false
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110002#
name: Hydroxymethylglutaryl-CoA reversible peroxisomal transport
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_95520b7b_0ad0_4380_bb1a_26cfd69637d8
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:8525
initial concentration: NaN
name: DGKZ
type: Species
is: G3V0F6
has only substance units: false

metaR SIAASEly
is version of: http://identifiers.org/ec-code/3.2.1.23
name: sialidase, lysosomal
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
product: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18

metaM 12ppd S c
notes: FORMULA: C3H8O2 CHARGE: 0 INCHI: InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m0/s1
is: CHEBI:29002
is: SBO:0000247
name: (S)-propane-1,2-diol
constant: false
is: HMDB06213
type: Species
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR ARACHCPT1
notes: GENE_ASSOCIATION: (1375.3) or (1374.1) or (1375.2) or (1375.4) or (1375.1) or (126129.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
reversible: false
product: MODEL1310110002#
fast: false
name: carnitine transferase
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
is described by: ECO:0000000

metaM fad c
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
is: CHEBI:16238
type: Species
constant: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: Flavin adenine dinucleotide oxidized
is: C00016
is: HMDB01248
boundary condition: false
initial amount: NaN

metaR r0539
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.13.11.19 Confidence Level: 0 AUTHORS: PMID:17153586,PMID:17581819,PMID:3657558 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.34
reactant: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
name: Cysteamine:oxygen oxidoreductase Taurine and hypotaurine metabolism EC:1.13.11.19
reversible: true
type: Reaction

metaR UDPGLCAter
is: SBO:0000185
notes: GENE_ASSOCIATION: (23169.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11322953 NOTES:NCD
fast: false
name: UDPGlcA endoplasmic reticulum transport via UMP antiport
kinetic law: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110002#
product: MODEL1310110002#

metaR GLYBtm
fast: false
is described by: ECO:0000000
product: MODEL1310110002#
is: SBO:0000185
kinetic law: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8443213 NOTES:MM
name: Glycine betaine transport via diffusion (mitochondria to cytosol)

metaM abt e
type: Species
is: CHEBI:18403
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
is: HMDB01851
name: L-arabinitol

metaR DHORTS
product: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000269
modifier: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/2.1.3.2
kinetic law: MODEL1310110002#
name: dihydroorotase
reversible: true
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_06eb8337_0632_4c81_bd0e_e4add9ecdc21
type: Species
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
name: LCT
is: P09848
is encoded by: hsa:3938
initial concentration: NaN

metaR SPODMn
type: Reaction
kinetic law: MODEL1310110002#
name: superoxide dismutase, nuclear
reversible: false
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/1.15.1.1
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
product: MODEL1310110002#

metaR r1567
reversible: true
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is: SBO:0000185

metaM lac L e
is: CHEBI:16651
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: (S)-lactate
is: HMDB00190
type: Species
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_a371062b_8fce_46a7_bec2_fcd7cb2a9467
boundary condition: true
name: SLC9A1
type: Species
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:6548
initial amount: NaN
is: P19634
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_db01ade5_3ef7_4f30_9ec1_4f282457a2f0
is: SBO:0000252
boundary condition: true
has only substance units: false
name: _LOC374569_1_e
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:LOC374569
initial concentration: NaN

metaR ACOAD8m
is: SBO:0000176
modifier: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (3712.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.10 Confidence Level: 4 AUTHORS: PMID:9214289 NOTES:MM
fast: false
reversible: false
kinetic law: MODEL1310110002#
is described by: ECO:0000269
name: acyl-CoA dehydrogenase (isovaleryl-CoA), mitochondrial
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.99.10

http://identifiers.org/biomodels.db/MODEL1310110002#_c16c5db9_b1b2_4c7c_9e0b_e3815d50558f
constant: false
is encoded by: hsa:AA664770
type: Species
initial amount: NaN
boundary condition: true
name: _AA664770_1_m
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_1e8a862a_2cb6_4dd1_ae38_6f79197b9be5
type: Species
is encoded by: hsa:29085
initial concentration: NaN
name: PHPT1
constant: false
is: SBO:0000252
initial amount: NaN
is: Q9P019
boundary condition: true
has only substance units: false

metaR NDPK3n
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reversible: true
is: SBO:0000176
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_f25ee392_9ac4_43e8_8f09_c0e177395773
has only substance units: false
initial amount: NaN
name: NDUFV2
initial concentration: NaN
is encoded by: hsa:4729
type: Species
is: P19404
constant: false
is: SBO:0000252
boundary condition: true

metaR RTOTAL2t
product: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
name: RTOTAL2 transport
reactant: MODEL1310110002#
fast: false
reversible: true
kinetic law: MODEL1310110002#

metaR r1566
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction

metaM dsT antigen g
initial concentration: 1.0
name: disialyl-T antigen
is: HMDB01440
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
is: CHEBI:16497
constant: false
initial amount: NaN
notes: FORMULA: C36H56N3O26X CHARGE: -2

metaR RE1709C
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
name: RE1709
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
fast: false
product: MODEL1310110002#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_8147b603_2607_43a0_99c1_c9368622638d
is encoded by: hsa:159963
constant: false
has only substance units: false
name: SLC5A12
is: Q1EHB4
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species

metaM 5adtststerone e
is: CHEBI:16330
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB02961
initial amount: NaN
name: 17beta-hydroxy-5alpha-androstan-3-one
initial concentration: 1.0
constant: false
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917

metaM pi e
is: SBO:0000247
is: CHEBI:43474
type: Species
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
initial amount: NaN
initial concentration: 1.0
is: HMDB00973
name: hydrogenphosphate
has only substance units: false
boundary condition: false
is: C00009
constant: false

metaM tetdecdicoa m
has only substance units: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
type: Species
constant: false
is: HMDB02288
initial concentration: 1.0
name: 5,8-tetradecadienoylcoa
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaR GLYCTDle
name: difussion of glycerol accross the brush border membrane
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
type: Reaction
is described by: ECO:0000134
is: SBO:0000185

metaM dec24dicoa m
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
name: 2,4-decadienoylcoa
boundary condition: false
is: HMDB01168
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
has only substance units: false

metaM acglcgalgbside hs g
is: CHEBI:26174
has only substance units: false
name: GlcNAc-Gal globoside
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN

metaR URIt
type: Reaction
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110002#
reactant: MODEL1310110002#
name: uridine facilated transport in cytosol
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
is described by: ECO:0000269

metaR ALAR
is described by: ECO:0000212
name: alanine racemase
modifier: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_d838615d_3816_4226_b7e4_4e2d8eadae77
constant: false
is encoded by: hsa:8613
is: SBO:0000252
name: PPAP2B
initial amount: NaN
initial concentration: NaN
is: O14495
type: Species
boundary condition: true
has only substance units: false

metaR HMGCOARc
is described by: ECO:0000134
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.34
product: MODEL1310110002#
is: SBO:0000176
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).

metaM mthgxl c
notes: FORMULA: C3H4O2 CHARGE: 0 INCHI: InChI=1S/C3H4O2/c1-3(5)2-4/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00425 EHMN_ABBREVIATION: C00546
type: Species
has only substance units: false
is: CHEBI:17158
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
name: methylglyoxal
initial concentration: 1.0
is: HMDB01167

metaR DOPABMO
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.14.17.1 Confidence Level: 4 AUTHORS: NOTES:SAB
modifier: MODEL1310110002#
name: dopamine beta-monooxygenase
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.17.1
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reversible: false
reactant: MODEL1310110002#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_ae5999d0_362e_4f2e_b50d_8c81fab10f3a
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:131
initial amount: NaN
name: ADH7
is: P40394

metaR r1914
modifier: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false
is: SBO:0000185
fast: false
reactant: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
type: Reaction

metaR S2L2FN2M2MASNt
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
reversible: false
product: MODEL1310110002#
name: s2l2fn2m2masn transport, Golgi to extracellular
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#

metaR NDPK3m
type: Reaction
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000254
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reversible: true
is: SBO:0000176
product: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110002#_5f9d62cb_844d_4992_afde_b7a228642da7
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1603
type: Species
initial concentration: NaN
is: Q53G02
name: DAD1
boundary condition: true
initial amount: NaN
constant: false

metaR UGALNACtg
modifier: MODEL1310110002#
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
kinetic law: MODEL1310110002#
name: UDP-GalNAc Golgi transport via CMP antiport
fast: false
reversible: true

metaM dcdp n
constant: false
type: Species
is: CHEBI:58593
initial amount: NaN
is: HMDB01245
name: dCDP(3-)
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_94770aff_153e_4768_9f5a_32182d6b0187
initial concentration: NaN
is encoded by: hsa:48
has only substance units: false
constant: false
is: P21399
is: SBO:0000252
type: Species
name: ACO1
boundary condition: true
initial amount: NaN

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_f47327c3_4163_43aa_8c6a_686e4043fb38
boundary condition: true
initial concentration: NaN
is encoded by: hsa:284111
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
name: SLC13A5
is: Q86YT5
has only substance units: false

metaR r1565
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_8be43cd2_e806_4eeb_bb58_13a4dfab6b1e
initial concentration: NaN
boundary condition: true
constant: false
is: Q8NCG5
type: Species
name: CHST4
is encoded by: hsa:10164
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM stcoa m
is: HMDB01114
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
type: Species
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:57394
name: Stearoyl-CoA (n-C18:0CoA)
is: C00412
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM lac L c
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: (S)-lactate
is: CHEBI:16651
constant: false
is: HMDB00190
is: SBO:0000247
initial amount: NaN

metaM man l
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00154 EHMN_ABBREVIATION: C00159
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: HMDB00169
is: SBO:0000247
is: CHEBI:16024
constant: false
type: Species
boundary condition: false
name: D-mannose

metaR RE1516M
product: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
is: SBO:0000176
name: RE1516
is version of: http://identifiers.org/ec-code/1.3.99.13
kinetic law: MODEL1310110002#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
modifier: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:

metaR EX glc LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Glucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_9ceecb63_7308_4aa9_84d9_948ecfa657be
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: F8W1L5
initial concentration: NaN
name: GPD1
constant: false
is encoded by: hsa:2819

metaM itaccoa m
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
is: CHEBI:57381
type: Species
has only substance units: false
name: itaconyl-CoA(5-)
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB03377
initial amount: NaN
constant: false

metaM ksii core2 deg6 l
initial amount: NaN
notes: FORMULA: C44H72N4O33SX CHARGE: -1
boundary condition: false
is: HMDB00143
initial concentration: 1.0
constant: false
name: keratan sulfate II (core 2-linked), degradation product 6
is: CHEBI:12936
is: SBO:0000247
type: Species
has only substance units: false

metaR APOC LYS BTNP
type: Reaction
is: SBO:0000176
name: proteolysis of apoC-Lys-btn
reversible: false
kinetic law: MODEL1310110002#
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110002#

metaM cysam c
is: CHEBI:58029
has only substance units: false
constant: false
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
is: SBO:0000247
initial amount: NaN
boundary condition: false
type: Species
is: HMDB02991
name: cysteaminium
initial concentration: 1.0

metaM pi c
name: hydrogenphosphate
is: CHEBI:43474
boundary condition: false
has only substance units: false
is: HMDB00973
constant: false
initial concentration: 1.0
is: C00009
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: HO4P CHARGE: -2

metaM trdrd c
boundary condition: false
type: Species
name: Reduced thioredoxin
has only substance units: false
is: SBO:0000247
is: CHEBI:15967
initial amount: NaN
initial concentration: 1.0
constant: false
is: C00342
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342

metaR HAS2
reactant: MODEL1310110002#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
fast: false
name: hyaluronan synthase
type: Reaction
modifier: MODEL1310110002#
reversible: false
is: SBO:0000185
is version of: http://identifiers.org/ec-code/2.4.1.212
product: MODEL1310110002#
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_24fc3540_1562_4a43_b48b_402dc6236b00
has only substance units: false
name: ALG12
initial concentration: NaN
is: Q9BV10
is encoded by: hsa:79087
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false

metaM 5adtststerone c
type: Species
is: SBO:0000247
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:16330
is: HMDB02961
initial amount: NaN
name: 17beta-hydroxy-5alpha-androstan-3-one

metaR r1564
reactant: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110002#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_7ad3da7b_7363_49a6_a4db_20275c107e96
initial amount: NaN
name: ACAA2
is encoded by: hsa:10449
constant: false
boundary condition: true
has only substance units: false
is: P42765
initial concentration: NaN
type: Species
is: SBO:0000252

metaM 4ppan c
is: HMDB01016
is: CHEBI:10986
boundary condition: false
is: C03492
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
constant: false
is: SBO:0000247
name: D-4'-Phosphopantothenate
type: Species
initial concentration: 1.0

metaM gsn e
is: HMDB00133
initial concentration: 1.0
is: CHEBI:16750
is: C00387
constant: false
has only substance units: false
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
type: Species
name: Guanosine
boundary condition: false
initial amount: NaN
is: SBO:0000247

metaM nmn c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C00455
is: CHEBI:14649
type: Species
has only substance units: false
notes: FORMULA: C11H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00366 EHMN_ABBREVIATION: C00455
is: HMDB00229
is: SBO:0000247
name: NMN
constant: false

metaM acrn c
type: Species
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
initial amount: NaN
is: HMDB00201
name: O-acetylcarnitine
has only substance units: false
is: CHEBI:57589
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_6b5ff266_41e5_4a84_bbec_cf45e4e47e0b
constant: false
is encoded by: hsa:4707
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: NDUFB1
initial concentration: NaN
boundary condition: true
type: Species
is: O75438

metaM asn L m
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:17196
boundary condition: false
is: HMDB00168
is: SBO:0000247
name: L-asparagine
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148

metaR G3PD1
fast: false
name: glycerol-3-phosphate dehydrogenase (NAD)
reversible: true
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110002#
product: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is version of: http://identifiers.org/ec-code/1.1.1.8
kinetic law: MODEL1310110002#
is: SBO:0000176

metaR 3HBCOAHLm
kinetic law: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
reversible: false
fast: false
reactant: MODEL1310110002#
type: Reaction
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.4 Confidence Level: 2 AUTHORS: PMID:8824301 NOTES:MM

metaR S2L2FN2M2MASNtly
product: MODEL1310110002#
is: SBO:0000185
name: s2l2fn2m2masn transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
fast: false

metaR r0488
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
reversible: true
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110002#

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_4c751bc6_8625_4e6b_98b7_b9faddc0b966
initial amount: NaN
has only substance units: false
is: P31937
initial concentration: NaN
is: SBO:0000252
name: HIBADH
type: Species
is encoded by: hsa:11112
constant: false
boundary condition: true

metaM drib c
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
is: HMDB03224
is: CHEBI:28816
initial amount: NaN
type: Species
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
name: 2-deoxy-D-ribose

metaM uacgam c
initial amount: NaN
is: HMDB00290
is: SBO:0000247
constant: false
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
boundary condition: false
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
type: Species
has only substance units: false
is: CHEBI:57705

metaR CORE3GTg
modifier: MODEL1310110002#
fast: false
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (192134.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.147 Confidence Level: 0 AUTHORS: PMID:11821425 NOTES:NCD
product: MODEL1310110002#
name: Core 3 beta-GlcNAc-transferase, Golgi apparatus
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
kinetic law: MODEL1310110002#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_05e2dd09_1ad8_48ef_8652_9506ef75480a
name: ACOT4
is encoded by: hsa:122970
boundary condition: true
is: Q8N9L9
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
type: Species

metaM ksi pre30 g
is: HMDB00175
boundary condition: false
type: Species
is: CHEBI:58053
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 30
initial concentration: 1.0
is: C00130
notes: FORMULA: C219H350N15O184S9X CHARGE: -10
has only substance units: false
constant: false
initial amount: NaN

metaR FUMm
fast: false
reversible: true
product: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
is version of: http://identifiers.org/ec-code/4.2.1.2
is described by: ECO:0000134
is: SBO:0000176
name: fumarase, mitochondrial
type: Reaction

metaR r1812
name: Y+LAT2 Utilized transport
is: SBO:0000185
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110002#_f5fbcb35_0ae7_4f50_a3f9_68657465ebf6
initial concentration: NaN
is encoded by: hsa:8704
has only substance units: false
boundary condition: true
name: B4GALT2
type: Species
initial amount: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_11fa4562_bd71_49f2_ab87_ae72c60004f8
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:8813
has part: O94777
is: SBO:0000297
constant: false
name: DPM3:DPM1:DPM2
has part: Q86TM7
is encoded by: hsa:8818
is encoded by: hsa:54344
has part: O60762

metaM HC00342 m
name: cis-aconitate(3-)
is: CHEBI:16383
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C6H3O6 CHARGE: -3 INCHI: InChI=1S/C6H6O6/c7-4(8)1-3(6(11)12)2-5(9)10/h1H,2H2,(H,7,8)(H,9,10)(H,11,12)/p-3/b3-1- EHMN_ABBREVIATION: C00417
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_a30d4ebf_abbd_433a_9a16_16cdd403c9d8
has only substance units: false
name: DDO
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:8528
is: Q99489
initial amount: NaN

metaR r2341
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaR EX 34hpp
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaR BTNPL
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/6.3.4.10
reversible: false
product: MODEL1310110002#
name: holocarboxylase synthestase (biotin protein ligase)
modifier: MODEL1310110002#
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_metaR_EX_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Type IIIAb exchange
type: Reaction

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_d9480e6e_34da_43fc_af7a_f807bb9e9c10
is encoded by: hsa:6389
has only substance units: false
boundary condition: true
type: Species
is: P31040
name: SDHA
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR XOL7AONEtr
fast: false
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_9b7d7b4c_7e13_4abe_8c1b_743a3b0cdb61
is encoded by: hsa:10317
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
name: B3GALT5

metaR ORNDC
product: MODEL1310110002#
is: SBO:0000176
name: Ornithine Decarboxylase
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance
is version of: http://identifiers.org/ec-code/4.1.1.17
modifier: MODEL1310110002#
is described by: ECO:0000269
type: Reaction
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_172b2b6f_7f32_43f0_9316_62740e9af4ad
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:4701
constant: false
boundary condition: true
is: Q6FG42
has only substance units: false
initial amount: NaN
name: NDUFA7

metaR S6TASE22ly
is described by: ECO:0000000
product: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110002#
reversible: true
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: galactose-6-sulfate sulfatase, lysosomal
type: Reaction
is: SBO:0000176

metaR G6PPer
is: SBO:0000176
reversible: false
name: glucose-6-phosphate phosphatase, edoplasmic reticular
fast: false
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.1.3.9
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
kinetic law: MODEL1310110002#
type: Reaction
is described by: ECO:0000269
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_f2406d31_bb87_41a7_a24a_44779e55dcc0
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110002#_dfa20ecd_37eb_49c3_a541_b699625e78e2
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: GART
is: SBO:0000252
is: Q59HH3
is encoded by: hsa:2618
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_887c88f9_2a17_41be_ac8c_fb76e0f775fd
initial concentration: NaN
name: ACSS3
type: Species
has only substance units: false
is: Q9H6R3
initial amount: NaN
is encoded by: hsa:79611
is: SBO:0000252
boundary condition: true
constant: false

metaR r1109
reactant: MODEL1310110002#
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
product: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
reversible: true
is described by: ECO:0000000

metaM pac c
is: SBO:0000247
type: Species
notes: FORMULA: C8H7O2 CHARGE: -1 INCHI: InChI=1S/C8H8O2/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC01781 EHMN_ABBREVIATION: C07086
initial concentration: 1.0
name: phenylacetate
constant: false
is: CHEBI:18401
boundary condition: false
is: HMDB00209
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_3880b9de_b1ea_4b20_85cd_0a4d00b5c41c
is encoded by: hsa:2542
type: Species
name: SLC37A4
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: A8K0S7
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_19a16762_7955_4ecc_969d_cd807c54338b
is: SBO:0000252
initial amount: NaN
is: Q8TF08
name: COX7B2
boundary condition: true
is encoded by: hsa:170712
type: Species
has only substance units: false
initial concentration: NaN
constant: false

metaM C04849 e
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-10-13-18-19(24-18)16-15-17(21)12-9-7-8-11-14-20(22)23/h6-7,9-10,15-19,21H,2-5,8,11-14H2,1H3,(H,22,23)/p-1/b9-7-,10-6-,16-15+/t17?,18-,19+/m0/s1 EHMN_ABBREVIATION: C04849
initial concentration: 1.0
type: Species
is: CHEBI:57449
boundary condition: false
has only substance units: false
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate
initial amount: NaN
is: SBO:0000247

metaM ksii core2 pre8 g
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C75H121N6O56SX CHARGE: -2
initial amount: NaN
is: C00130
name: keratan sulfate II biosynthesis, precursor 8
initial concentration: 1.0
type: Species
is: CHEBI:58053
is: HMDB00175
boundary condition: false

metaR ACACT5p
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
type: Reaction
is described by: ECO:0000269
reversible: false
fast: false
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110002#

MODEL1310110002
reaction: metaR GLCAASE8ly
reaction: metaR LNLNCGt
reaction: metaR PNTEH
species: metaM dgdp n
species: metaM dhap m
species: metaM 4hexdtetcoa m
reaction: metaR NDPK1
reaction: metaR 3HCO3 NAt
species: metaM so4 c
species: metaM pglyc hs c
reaction: metaR NACHEX4ly
species: metaM succ c
reaction: metaR PAFH
reaction: metaR r2327
reaction: metaR S6TASE4ly
species: metaM dump m
species: metaM ksi pre24 g
species: metaM sbt D c
reaction: metaR r1396
reaction: metaR r1649
reaction: metaR EX xolest2 hs LPAREN e RPAREN
species: metaM urate c
reaction: metaR TSTSTERONEt
species: metaM crm hs r
species: metaM m8masn g
species: metaM o2 c
species: metaM Lkynr c
reaction: metaR 2AMADPTm
species: metaM dtmp c
reaction: metaR RE3568C
reaction: metaR SQLSr
reaction: metaR FUT17g
reaction: metaR RDH1a
reaction: metaR FAOXC6DCC4DCx
reaction: metaR r2013
reaction: metaR OROTGLUt
species: metaM arach c
species: metaM ac e
species: metaM cs d deg1 l
reaction: metaR EX citr L LPAREN e RPAREN
reaction: metaR r2097
reaction: metaR r2366
reaction: metaR r0716
reaction: metaR ASCBt4
species: metaM hdca c
reaction: metaR PA HSter
species: metaM e4p c
reaction: metaR Ser Thrtg
reaction: metaR ACGAMK
reaction: metaR CYTDt
species: metaM ksii core2 pre7 g
reaction: metaR DNDPt15m
species: metaM mal L c
reaction: metaR ABO6g
species: metaM duri c
species: metaM lnlnca r
species: metaM ksii core4 pre7 g
reaction: metaR r0641
reaction: metaR BTNPL
species: metaM hexdectecoa m
reaction: metaR r0385
species: metaM air c
species: metaM prostgf2 e
species: metaM thp2c x
reaction: metaR EX gthrd LPAREN e RPAREN
reaction: metaR G14T8g
species: metaM 3mb2coa m
species: metaM HC02179 e
reaction: metaR PROSTGH2t
species: metaM oxa e
reaction: metaR MG3er
species: metaM adp e
reaction: metaR r1600
reaction: metaR FAOXC121C10x
species: metaM 10fthf c
reaction: metaR 4HPRO LTte
reaction: metaR ACACT5p
species: metaM s2l2fn2m2masn l
reaction: metaR URATEt
species: metaM fuc L c

metaM focytC m
type: Species
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124
initial amount: NaN
initial concentration: 1.0
name: Ferrocytochrome C
is: CHEBI:16928
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false

metaR r0818
reversible: false
product: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12657464,PMID:14519855,PMID:16194150 NOTES:
is described by: ECO:0000000
fast: false
name: Transport reaction
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_f0c6f86c_4cf2_49b5_bf77_168b30d2d389
is encoded by: hsa:55350
name: VNN3:VNN2:VNN1
boundary condition: true
is: SBO:0000297
constant: false
has only substance units: false
initial concentration: NaN
type: Species
initial amount: NaN
has part: O95498
is encoded by: hsa:8875

metaR PNTEH
type: Reaction
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) SUBSYSTEM: CoA catabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10567687,PMID:11491533 NOTES:EC 3.5.1- KEGG RXN R02973 RM
kinetic law: MODEL1310110002#
reversible: false
modifier: MODEL1310110002#
name: Hydrolase Class ( RXN R02973)
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.5.1.92
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_4ea64d5c_e589_4b8e_87d8_17976b3e3806
has only substance units: false
name: SLC29A1
is encoded by: hsa:2030
is: Q99808
initial concentration: NaN
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true

metaR GLCAASE9ly
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reversible: false
reactant: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.31
fast: false
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD

metaM amet c
is: HMDB01185
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
name: S-Adenosyl-L-methionine
initial concentration: 1.0
notes: FORMULA: C15H23N6O5S CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
is: C00019
is: CHEBI:15414

metaM hdca c
initial amount: NaN
type: Species
initial concentration: 1.0
is: HMDB00220
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
name: palmitate
notes: FORMULA: C16H31O2 CHARGE: -1 INCHI: InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)/p-1 HEPATONET_1.0_ABBREVIATION: HC00226 EHMN_ABBREVIATION: C00249
is: CHEBI:7896

http://identifiers.org/biomodels.db/MODEL1310110002#_32ea144a_92a9_404b_828d_c170d0622f84
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: NAGA
is: P17050
initial concentration: NaN
constant: false
is encoded by: hsa:4668
has only substance units: false

metaM arachcoa c
is: CHEBI:15527
type: Species
is: HMDB04258
boundary condition: false
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial amount: NaN
has only substance units: false
constant: false
name: arachidyl coenzyme A
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_fucgalacglc13galacglcgal14acglcgalgluside_hs_g
type: Species
initial concentration: 1.0
is: HMDB00257
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
is: SBO:0000247
is: CHEBI:16094
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)1 (Cer)1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_ab1831a3_48da_4d0a_b51b_192fcd278242
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
type: Species
boundary condition: true
name: ALDH1B1
is: P30837
initial concentration: NaN
is encoded by: hsa:219

http://identifiers.org/biomodels.db/MODEL1310110002#_85c93880_9352_4f3d_a534_c194f8ce430a
type: Species
boundary condition: true
initial amount: NaN
is: Q02742
is encoded by: hsa:2650
constant: false
name: GCNT1
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_c
initial amount: NaN
type: Species
is: HMDB01659
name: Type IIIAb
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
is: CHEBI:15347

http://identifiers.org/biomodels.db/MODEL1310110002#_ef15987d_2972_4bfa_b615_c0f7a6f448dc
is: SBO:0000252
initial amount: NaN
name: SLC7A6
is: Q92536
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:9057
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_0172c89b_68c4_415c_9dbe_dc928f83ddcb
name: NDUFB4
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
is: O95168
is encoded by: hsa:4710
has only substance units: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_ec9bafa9_a3eb_4e08_a4fa_9669acb8d57b
initial amount: NaN
is encoded by: hsa:63917
constant: false
name: GALNT11
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
is: B3KWF4
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_3212ad26_8a0f_4163_97d3_27e77e5bfd33
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6539
is: P48065
constant: false
type: Species
name: SLC6A12

metaR r0817
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.3.2
is described by: ECO:0000000
reversible: true
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.41
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.85
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10072483,PMID:10391915,PMID:10574970,PMID:11004451,PMID:11311135,PMID:11389679,PMID:11557028,PMID:11564694,PMID:11742812,PMID:11827462,PMID:12117417,PMID:12824232,PMID:12883891,PMID:14574404,PMID:14770310,PMID:15465786,PMID:16082501,PMID:16288981,PMID:17466261,PMID:1904693,PMID:4424190,PMID:6432599,PMID:7690540,PMID:7718542,PMID:9751058,PMID:9759917,PMID:9868191 NOTES:
is: SBO:0000185
modifier: MODEL1310110002#
fast: false

metaM pi g
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
constant: false
is: HMDB00973
is: CHEBI:43474
type: Species
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: hydrogenphosphate

http://identifiers.org/biomodels.db/MODEL1310110002#_6906afcc_ae6b_4cf4_8530_169a68bbd062
name: CDO1
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:1036
boundary condition: true
is: Q16878
initial concentration: NaN
type: Species

metaR DCYTD
name: deoxycytidine deaminase
is version of: http://identifiers.org/ec-code/3.5.4.5
modifier: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000254
is: SBO:0000176
notes: GENE_ASSOCIATION: (978.1) or (57379.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.14 Confidence Level: 2 AUTHORS: PMID:14744791,PMID:15087440,PMID:7923172,PMID:8001985,PMID:8422236 NOTES:
kinetic law: MODEL1310110002#
fast: false
type: Reaction
reversible: false
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_f19c9bc6_4d83_4059_afc0_865357715d15
initial amount: NaN
is: Q8TE04
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
name: PANK1
is encoded by: hsa:53354
has only substance units: false
boundary condition: true

metaM cs c deg1 l
has only substance units: false
boundary condition: false
type: Species
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 1
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00812
constant: false
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
is: CHEBI:16953

metaR TRIODTHYt2
fast: false
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110002#
reversible: true
type: Reaction
is: SBO:0000185
reactant: MODEL1310110002#
name: T3 transport via facilitated diffusion
product: MODEL1310110002#

metaM HC01609 e
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766
name: UroporphyrinogenI
is: CHEBI:28766
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_b2f2f805_729f_4fb5_8b31_934075a9fcc7
has only substance units: false
constant: false
is encoded by: hsa:51251
name: NT5C3
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q9H0P0
initial amount: NaN
boundary condition: true

metaR r2048
reactant: MODEL1310110002#
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
fast: false

metaR FUMAC
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
is version of: http://identifiers.org/ec-code/3.7.1.2
kinetic law: MODEL1310110002#
is described by: ECO:0000269
reversible: false
name: fumarylacetoacetase
fast: false
product: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000176
reactant: MODEL1310110002#

metaR FOLR2
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/1.5.1.3
kinetic law: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
fast: false
name: folate reductase
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false

metaM ksi pre7 g
notes: FORMULA: C115H187N8O85SX CHARGE: -2
type: Species
is: HMDB00175
constant: false
boundary condition: false
is: C00130
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 7
is: CHEBI:58053
is: SBO:0000247
has only substance units: false

metaM pi n
is: CHEBI:43474
notes: FORMULA: HO4P CHARGE: -2 INCHI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: SBO:0000247
name: hydrogenphosphate
initial concentration: 1.0
initial amount: NaN
constant: false
is: HMDB00973
boundary condition: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_4f5d4039_7d4b_40c3_9c3b_7c3f3813d9cc
initial amount: NaN
is encoded by: hsa:4712
type: Species
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
has part: Q5VYT2
initial concentration: NaN
is encoded by: hsa:4731
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000297

metaM 7dhchsterol r
is: SBO:0000247
name: cholesta-5,7-dien-3beta-ol
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
boundary condition: false
is: CHEBI:17759
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: HMDB00032

metaM uacgam g
is: HMDB00290
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
has only substance units: false
initial concentration: 1.0
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
is: CHEBI:57705
type: Species

metaR r0531
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:9923963 NOTES:
fast: false
is described by: ECO:0000000
reactant: MODEL1310110002#
is: SBO:0000176
reversible: true
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.34
kinetic law: MODEL1310110002#
name: dUTP:cytidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48

metaR EX anth LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of anthranilate
type: Reaction

metaR r0812
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
modifier: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM hdca e
notes: FORMULA: C16H31O2 CHARGE: -1
is: C00249
constant: false
is: HMDB00220
is: SBO:0000247
is: CHEBI:0
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: Hexadecanoate (n-C16:0)
initial amount: NaN
type: Species

metaM rib D c
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00119
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: CHEBI:16988
name: D-ribose
type: Species
has only substance units: false
is: HMDB00283

metaM lac D c
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
is: SBO:0000247
initial amount: NaN
is: CHEBI:16004
constant: false
is: HMDB01311
type: Species
has only substance units: false
initial concentration: 1.0
name: (R)-lactate

metaR NRPPHRt4 2 r
reactant: MODEL1310110002#
fast: false
reversible: true
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
product: MODEL1310110002#
modifier: MODEL1310110002#
name: Norepinephrine reversible transport in via sodium symport (1:2)

metaM CE0785 m
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:57795
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785
name: cis,cis-myristo-5,8-dienoyl-CoA
has only substance units: false

metaR r1454
product: MODEL1310110002#
reversible: false
is: SBO:0000185
name: TCDB:2.A.1.13.5 TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
reactant: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:

metaM fad e
name: Flavin adenine dinucleotide oxidized
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C27H31N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00026 EHMN_ABBREVIATION: C00016
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00016
is: HMDB01248
is: CHEBI:16238

metaR MI1345PP
reactant: MODEL1310110002#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.36
is: SBO:0000176
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
is described by: ECO:0000269
fast: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_e794e07b_32ac_418b_95c2_e48180457f1b
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
is: O00483
type: Species
is encoded by: hsa:4697
name: NDUFA4

metaM pi m
is: SBO:0000247
initial amount: NaN
constant: false
has only substance units: false
name: hydrogenphosphate
notes: FORMULA: HO4P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00019 EHMN_ABBREVIATION: C00009
is: C00009
initial concentration: 1.0
is: CHEBI:43474
type: Species
boundary condition: false
is: HMDB00973

metaM g1m8masn r
boundary condition: false
type: Species
is: C05875
is: SBO:0000247
has only substance units: false
notes: FORMULA: C76H127N2O60X CHARGE: 0
initial concentration: 1.0
constant: false
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
initial amount: NaN

metaM pmtcrn c
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: HMDB00222
type: Species
has only substance units: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: CHEBI:17490
constant: false
name: L-palmitoylcarnitine
is: SBO:0000247

metaR CYTDt
modifier: MODEL1310110002#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
is: SBO:0000185
name: cytidine facilated transport in cytosol
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
type: Reaction
product: MODEL1310110002#

metaM mag hs e
has only substance units: false
initial amount: NaN
name: monoacylglycerol 2
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C3H7O2FULLR2CO2 CHARGE: 0
is: SBO:0000247
is: CHEBI:32391
is: HMDB03073
boundary condition: false

metaR r0181
is described by: ECO:0000000
reactant: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.3
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
fast: false
reversible: true
is: SBO:0000176
modifier: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM trdrd m
name: Reduced thioredoxin
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: XH2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00289 EHMN_ABBREVIATION: C00342
type: Species
is: CHEBI:15967

metaR r2344
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
reversible: true

metaR r1453
type: Reaction
fast: false
name: L-proline:(acceptor) oxidoreductase Arginine and proline metabolism EC:1.5.99.8
reactant: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: 0 AUTHORS: PMID:18506409 NOTES:

metaR SPODMx
type: Reaction
reversible: false
reactant: MODEL1310110002#
is described by: ECO:0000269
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
modifier: MODEL1310110002#
is: SBO:0000176
fast: false
name: superoxide dismutase, peroxisome
is version of: http://identifiers.org/ec-code/1.15.1.1
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_031ed811_6c70_46d9_8e97_6a1ed9517733
constant: false
initial concentration: NaN
boundary condition: true
name: PRDX2
type: Species
initial amount: NaN
is encoded by: hsa:7001
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_97aa4e77_134b_446f_9e00_f301110abbcf
name: SLCO2A1
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is encoded by: hsa:6578
is: SBO:0000252
is: Q92959

http://identifiers.org/biomodels.db/MODEL1310110002#_98e301de_f2ab_49e1_ab14_8b4fdaef39cc
is encoded by: hsa:55568
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: GALNT10
initial concentration: NaN

metaM CE2418 m
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
type: Species
initial concentration: 1.0
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
constant: false
is: CHEBI:28387
has only substance units: false
is: HMDB11123
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_e5bf54db_fb67_42e3_8fc4_2305dcbea564
has only substance units: false
is: Q9NR34
is encoded by: hsa:57134
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
name: MAN1C1
initial amount: NaN
constant: false

metaM 3hbcoa m
initial amount: NaN
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
is: HMDB01166
has only substance units: false
name: (S)-3-hydroxybutanoyl-CoA(4-)
is: CHEBI:57316
constant: false

metaR FK
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
is version of: http://identifiers.org/ec-code/2.7.1.52
reactant: MODEL1310110002#
name: Fucokinase
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
is: SBO:0000176

metaM drib e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:28816
type: Species
boundary condition: false
initial amount: NaN
is: HMDB03224
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
name: 2-deoxy-D-ribose

http://identifiers.org/biomodels.db/MODEL1310110002#_c19ceaf0_ac53_4791_995e_456e370681ed
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:89869
boundary condition: true
name: PLCZ1
is: Q86YW0
is: SBO:0000252
initial concentration: NaN
type: Species

metaM lac D e
is: HMDB01311
has only substance units: false
is: SBO:0000247
name: (R)-lactate
constant: false
boundary condition: false
is: CHEBI:16004
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m1/s1
initial concentration: 1.0
type: Species
initial amount: NaN

metaR B3GNT314g
modifier: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000254
type: Reaction
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
kinetic law: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110002#_70336d2c_99f8_46b8_ab01_40b371d488e3
name: NDUFB8
boundary condition: true
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is: O95169
is encoded by: hsa:4714
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_aab85074_6a28_4cf0_89fc_3b0128562819
boundary condition: true
name: SLC25A13
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10165
is: Q9UJS0
has only substance units: false
type: Species
constant: false
initial amount: NaN

metaM odecoa c
is: SBO:0000247
initial concentration: 1.0
is: HMDB01322
name: Octadecenoyl-CoA (n-C18:1CoA)
initial amount: NaN
is: CHEBI:3793
constant: false
has only substance units: false
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
type: Species
boundary condition: false

metaR r0480
is: SBO:0000176
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_9089f564_e143_4186_9bc4_bc6eb71fce8c
is: SBO:0000252
type: Species
initial concentration: NaN
name: DPM2
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:8818
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_ab66f846_058a_4df5_93d1_885d0d722b7d
is: Q308M7
is: SBO:0000252
constant: false
has only substance units: false
name: ENPP3
initial concentration: NaN
is encoded by: hsa:5169
type: Species
boundary condition: true
initial amount: NaN

metaR Htx
kinetic law: MODEL1310110002#
name: H transporter, peroxisome
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110002#
fast: false
type: Reaction
product: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ

metaM mev R c
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: SBO:0000247
is: HMDB00227
has only substance units: false
name: (R)-mevalonate
type: Species
initial amount: NaN
is: CHEBI:36464
constant: false
boundary condition: false
initial concentration: 1.0

metaR GALASE16ly
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.2.1.18
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
fast: false
product: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
name: beta-galactosidase, lysosomal
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110002#

metaM asn L e
boundary condition: false
constant: false
is: CHEBI:17196
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
name: L-asparagine
initial amount: NaN
is: HMDB00168

http://identifiers.org/biomodels.db/MODEL1310110002#_3d3e30fd_870a_4e68_a849_5bb5250aa119
is: SBO:0000252
has only substance units: false
is: O95299
type: Species
boundary condition: true
initial concentration: NaN
constant: false
name: NDUFA10
is encoded by: hsa:4705
initial amount: NaN

metaR r2342
is described by: ECO:0000000
reversible: true
is: SBO:0000185
reactant: MODEL1310110002#
fast: false
type: Reaction
product: MODEL1310110002#
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaR SERGLNexR
is: SBO:0000185
kinetic law: MODEL1310110002#
name: L-Serine/Glutamine reversible exchange
type: Reaction
reversible: true
product: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304
modifier: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_a4a414e6_f4aa_4406_97d8_678f98a3396a
type: Species
is: P31639
is encoded by: hsa:6524
constant: false
name: SLC5A2
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR NADS2
notes: GENE_ASSOCIATION: (55191.1) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110002#
reversible: false
name: NAD synthase (glutamine-hydrolysing)
is version of: http://identifiers.org/ec-code/6.3.5.1
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
product: MODEL1310110002#
is described by: ECO:0000269
fast: false
type: Reaction

metaM mmcoa S m
is: SBO:0000247
boundary condition: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13+,16+,17+,18-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00495
has only substance units: false
is: CHEBI:57327
is: HMDB02310
name: (S)-methylmalonyl-CoA(5-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_187eff51_2d43_4cc6_b29e_2cc4bf791731
initial concentration: NaN
initial amount: NaN
constant: false
name: PPT2
has only substance units: false
is: SBO:0000252
is: Q9UMR5
type: Species
is encoded by: hsa:9374
boundary condition: true

metaR SPC HSt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110002#
type: Reaction
name: sphingosylphosphorylcholine transport (diffusion)
reactant: MODEL1310110002#
fast: false
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_dbc064fd_1e3f_40d1_a02c_01bcd4bce9ee
initial concentration: NaN
name: CA13
is: Q8N1Q1
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:377677
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_7eabbaca_c691_4ef7_94eb_9c83f83bf9c5
constant: false
is: SBO:0000252
name: PMM1
initial amount: NaN
type: Species
boundary condition: true
is: A8K003
is encoded by: hsa:5372
has only substance units: false
initial concentration: NaN

metaR F6Tg
is version of: http://identifiers.org/ec-code/2.4.1.68
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
kinetic law: MODEL1310110002#
reversible: false
name: glycoprotein 6-alpha-L-fucosyltransferase
reactant: MODEL1310110002#
modifier: MODEL1310110002#
product: MODEL1310110002#

metaR RE3218C
name: RE3218
modifier: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Androgen and estrogen synthesis and metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:11886493 NOTES:IT - fixed proton
type: Reaction
reactant: MODEL1310110002#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.2
reversible: true
product: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false

metaR H2O2tp
reversible: true
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
is described by: ECO:0000000
fast: false
name: hydrogen peroxide peroxisomal transport via diffusion
product: MODEL1310110002#
is: SBO:0000185
kinetic law: MODEL1310110002#
type: Reaction

metaM dttp m
has only substance units: false
name: dTTP
is: C00459
constant: false
is: SBO:0000247
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
type: Species
initial amount: NaN
is: HMDB01342
boundary condition: false
initial concentration: 1.0
is: CHEBI:37568

metaM udpacgal c
is: CHEBI:57847
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB00304
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
has only substance units: false
name: UDP-N-acetyl-D-galactosamine(2-)
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_242ba00d_1f5d_4572_9b71_5641ca9acc3c
constant: false
has only substance units: false
is: Q9NYQ3
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: HAO2
is encoded by: hsa:51179

http://identifiers.org/biomodels.db/MODEL1310110002#_cadf0f90_e015_4f89_96e2_dc94e77af3d8
is: SBO:0000252
is: P07954
name: FH
initial concentration: NaN
is encoded by: hsa:2271
boundary condition: true
constant: false
type: Species
initial amount: NaN
has only substance units: false

metaR RE0452M
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
product: MODEL1310110002#
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
name: RE0452
is described by: ECO:0000000
fast: false

metaM tyr L c
is: SBO:0000247
has only substance units: false
name: L-tyrosine
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
boundary condition: false
is: CHEBI:17895
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00158

metaM cdp n
is: HMDB01546
has only substance units: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial amount: NaN
name: CDP(3-)
is: SBO:0000247
boundary condition: false
is: CHEBI:58069
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_23c808c2_48f4_4ef7_aace_a0743c553278
name: GALNT2
is: Q10471
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:2590
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_a67f2549_b6a8_4461_b2d6_29b12b32dc8e
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: GPX1
is encoded by: hsa:2876
initial concentration: NaN
type: Species
is: SBO:0000252

metaR 34HPPOR
is version of: http://identifiers.org/ec-code/1.13.11.27
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
fast: false
modifier: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
kinetic law: MODEL1310110002#
type: Reaction
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
product: MODEL1310110002#

metaR S6T2g
type: Reaction
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false

metaM ksii core4 pre1 g
boundary condition: false
is: SBO:0000247
notes: FORMULA: C36H60N3O25X CHARGE: 0
is: CHEBI:28067
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 1
type: Species
constant: false

metaM acrn x
is: CHEBI:57589
has only substance units: false
name: O-acetylcarnitine
notes: FORMULA: C9H17NO4 CHARGE: 0 INCHI: InChI=1S/C9H17NO4/c1-7(11)14-8(5-9(12)13)6-10(2,3)4/h8H,5-6H2,1-4H3/t8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00966 EHMN_ABBREVIATION: C02571
is: HMDB00201
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_82eccf77_729a_4e2e_a74e_ccfc74ec5cbf
has only substance units: false
name: ST3GAL3
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:6487
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_1057ccb9_a231_4ae3_8d4c_149459b94cb4
is: SBO:0000252
boundary condition: true
is encoded by: hsa:NM 013421
type: Species
name: _NM_013421_1_e
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false

metaM ha pre1 l
initial concentration: 1.0
has only substance units: false
name: hyaluronan biosynthesis, precursor 1
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
type: Species
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:16126

http://identifiers.org/biomodels.db/MODEL1310110002#_2ba81c64_1668_4f34_a235_c31c5b8aadad
is: Q53TV9
name: RPE
is encoded by: hsa:6120
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_0a42944b_1ebe_4b85_94e5_a001c11266d8
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
name: SLC4A8
boundary condition: true
has only substance units: false
is: E7EML0
is encoded by: hsa:9498

metaR AICART
type: Reaction
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
is described by: ECO:0000269
fast: false
reactant: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
modifier: MODEL1310110002#
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.1.2.3

metaM dttp n
is: HMDB01342
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H13N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00368 EHMN_ABBREVIATION: C00459
is: CHEBI:37568
name: dTTP
type: Species
initial amount: NaN
is: C00459
has only substance units: false

metaR r2051
type: Reaction
reversible: false
is: SBO:0000185
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#

metaR CYTDtm
is described by: ECO:0000269
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
is: SBO:0000185
name: cytidine facilated transport in mitochondria
type: Reaction
reversible: true
modifier: MODEL1310110002#

metaR r0399
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.2
type: Reaction
fast: false
product: MODEL1310110002#
modifier: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
is described by: ECO:0000000
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1

metaM chol m
initial amount: NaN
is: CHEBI:15354
is: SBO:0000247
constant: false
is: HMDB00097
name: choline
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false
boundary condition: false
initial concentration: 1.0
type: Species

metaR PROSTGH2t
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110002#
reversible: true
fast: false
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
product: MODEL1310110002#
name: Prostaglandin H2 transport

http://identifiers.org/biomodels.db/MODEL1310110002#_5426dbae_84b9_41d9_9042_e45d11bfe315
type: Species
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: UEVLD
is encoded by: hsa:55293
is: Q8IX04

http://identifiers.org/biomodels.db/MODEL1310110002#_519a77e2_efe8_43f8_b9ba_8d439ba77240
name: PANK2
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:80025
is: Q6P1K9
type: Species
is: SBO:0000252
has only substance units: false

metaR EX asp L LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Aspartate exchange
type: Reaction

metaM cdp m
name: CDP(3-)
is: CHEBI:58069
initial amount: NaN
is: SBO:0000247
is: HMDB01546
constant: false
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_632ac87e_fe2e_41a7_89e8_a5df750298d9
is encoded by: hsa:81539
is: Q9H2H9
has only substance units: false
initial amount: NaN
name: SLC38A1
constant: false
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_0bb077b0_b554_47c4_a98c_7f6f46686bd0
initial concentration: NaN
constant: false
type: Species
name: NDUFB4
has only substance units: false
is: O95168
boundary condition: true
initial amount: NaN
is encoded by: hsa:4710
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_824dfe5d_bd79_4b7c_9d79_76d012ad4a47
name: UAP1L1
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
is: Q3KQV9
type: Species
is encoded by: hsa:91373

metaR DALAt2r
reactant: MODEL1310110002#
fast: false
reversible: true
kinetic law: MODEL1310110002#
is described by: ECO:0000304
name: D-alanine transport via proton symport
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
is: SBO:0000185
modifier: MODEL1310110002#

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaM arachd e
has only substance units: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
constant: false
name: arachidonate
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:32395
type: Species
is: HMDB01043

http://identifiers.org/biomodels.db/MODEL1310110002#_0f741596_9e5d_4f9b_a188_ea16da504c84
has only substance units: false
is: Q9NX14
is encoded by: hsa:54539
boundary condition: true
type: Species
initial amount: NaN
constant: false
name: NDUFB11
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_b5a87ce2_eb14_4b87_93ca_90782458059e
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:PRO1933
type: Species
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: _PRO1933_1_m

metaM g1p c
is: C00103
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
name: D-Glucose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00103 EHMN_ABBREVIATION: C00103
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:58601
is: HMDB01586

http://identifiers.org/biomodels.db/MODEL1310110002#_df698144_1dfe_4671_b87b_e12597dafce5
boundary condition: true
is: P27707
constant: false
name: DCK
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:1633
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_8a9ec937_591a_4ea5_9c6d_da9e6ff37b5f
is: Q96KH8
is encoded by: hsa:6530
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
name: SLC6A2
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_e187a0be_48fa_472b_b788_e98e3cedcafe
type: Species
is: SBO:0000252
name: PAFAH1B2
initial concentration: NaN
is: A8DPS7
has only substance units: false
is encoded by: hsa:5049
constant: false
initial amount: NaN
boundary condition: true

metaR r2110
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110002#
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
type: Reaction

metaM acald m
has only substance units: false
is: HMDB00990
type: Species
boundary condition: false
initial amount: NaN
name: acetaldehyde
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15343
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084

metaR r0287
modifier: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
reversible: false
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
fast: false
type: Reaction
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000

metaR G14T6g
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
is described by: ECO:0000000
modifier: MODEL1310110002#
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
type: Reaction
reactant: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110002#_eb8dfec0_811e_4829_9aab_4fce9ca0c394
is encoded by: hsa:641371
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: E9KL42
has only substance units: false
name: ACOT1

metaM mi14p c
is: CHEBI:58282
type: Species
initial concentration: 1.0
is: HMDB00968
boundary condition: false
has only substance units: false
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
constant: false
is: SBO:0000247
initial amount: NaN

metaM acgam6p c
is: SBO:0000247
initial amount: NaN
name: N-acetyl-D-glucosamine 6-phosphate(2-)
is: CHEBI:57513
initial concentration: 1.0
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(10)9-5-7(12)6(11)4(18-8(5)13)2-17-19(14,15)16/h4-8,11-13H,2H2,1H3,(H,9,10)(H2,14,15,16)/p-2/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00303 EHMN_ABBREVIATION: C00357
has only substance units: false
constant: false
is: HMDB01062
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_3145548c_17fe_4f48_a38d_9b58af1b4e8d
initial amount: NaN
name: CHAT
has only substance units: false
boundary condition: true
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q6LEN6
is encoded by: hsa:1103

metaR PPD2CSPp
reactant: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
kinetic law: MODEL1310110002#
fast: false
is described by: ECO:0000000
reversible: false
name: PPD2CSPp

metaM tyr L e
boundary condition: false
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
is: SBO:0000247
is: CHEBI:17895
initial amount: NaN
is: HMDB00158
initial concentration: 1.0
has only substance units: false
constant: false
name: L-tyrosine
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_9a83bacb_e4a3_4efd_ae9a_674afa360b14
boundary condition: true
has only substance units: false
is encoded by: hsa:374907
is: Q7Z7M8
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: B3GNT8

metaR HMGCOASim
name: Hydroxymethylglutaryl CoA synthase (ir)
is version of: http://identifiers.org/ec-code/2.3.3.10
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
product: MODEL1310110002#
is described by: ECO:0000269
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_2514f3a1_b1ef_47eb_a88c_68e177ccc168
name: ENTPD3
constant: false
initial amount: NaN
boundary condition: true
is: O75355
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:956

http://identifiers.org/biomodels.db/MODEL1310110002#_c302ede7_cbac_43db_a598_f741bed76b28
name: OGDH
constant: false
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
is encoded by: hsa:4967
initial amount: NaN
is: Q02218

metaM 3mb2coa m
name: 3-methylbut-2-enoyl-CoA(4-)
boundary condition: false
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
is: HMDB01493
constant: false
is: CHEBI:57344
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaM 5adtststerone r
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
boundary condition: false
is: HMDB02961
name: 17beta-hydroxy-5alpha-androstan-3-one
initial amount: NaN
constant: false
is: CHEBI:16330
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_db6860a2_b101_4dd2_a207_6410f102dc9f
boundary condition: true
is: P59796
name: GPX6
initial concentration: NaN
is encoded by: hsa:257202
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_b8570364_68a6_4c6c_a3f1_c5ae702fdeef
initial concentration: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:218
constant: false
name: ALDH3A1
is: P30838
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_805dff1c_c5e0_4567_924c_01377920a5c3
is: P00558
initial concentration: NaN
is: SBO:0000252
name: PGK1
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:5230

metaR SUCCtp
is described by: ECO:0000000
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110002#
name: succinate transporter, peroxisome
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ

metaR r2111
type: Reaction
kinetic law: MODEL1310110002#
is: SBO:0000185
reversible: true
product: MODEL1310110002#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR DM anth
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for anthranilate
type: Reaction

metaM pacald c
is: HMDB06236
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H8O CHARGE: 0 INCHI: InChI=1S/C8H8O/c9-7-6-8-4-2-1-3-5-8/h1-5,7H,6H2 HEPATONET_1.0_ABBREVIATION: HC00448 EHMN_ABBREVIATION: C00601
type: Species
is: CHEBI:16424
is: SBO:0000247
initial concentration: 1.0
name: phenylacetaldehyde

metaR ADK1
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
is described by: ECO:0000269
product: MODEL1310110002#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.3
name: adenylate kinase
is: SBO:0000176

metaR 5ADTSTSTERONEte
name: 5 alpha dihydrotesterone transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false

metaM pail3p hs c
is: CHEBI:58088
is: SBO:0000247
type: Species
name: 1-phosphatidyl-1D-myo-inositol 3-phosphate(3-)
constant: false
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C04549
initial concentration: 1.0
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_f03616e7_9d48_418a_a429_f190ab2daa09
type: Species
name: PLCE1
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:51196
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: Q9P212

metaR DOLPMT2 Uer
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
fast: false
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
kinetic law: MODEL1310110002#
is: SBO:0000176
type: Reaction

metaR PNP
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14704851,PMID:9030766 NOTES:IT
type: Reaction
name: purine-nucleoside phosphorylase
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110002#
product: MODEL1310110002#

metaM glcur c
type: Species
is: HMDB00127
constant: false
initial amount: NaN
is: CHEBI:15748
is: SBO:0000247
boundary condition: false
name: D-glucuronate
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
has only substance units: false
initial concentration: 1.0

metaR EX oagd3 hs LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 9-O-Acetylated GD3 (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_d8e1663f_4405_4959_8020_ba6e8007b8a9
initial concentration: NaN
constant: false
is encoded by: hsa:4729
name: NDUFV2
initial amount: NaN
is: P19404
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_ef90de31_8e56_4d0d_a148_005b58f5c295
constant: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9060
has only substance units: false
name: PAPSS2
initial concentration: NaN
is: O95340
initial amount: NaN

metaM arachd c
type: Species
is: HMDB01043
initial amount: NaN
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
boundary condition: false
name: arachidonate
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:32395

metaR r0179
is version of: http://identifiers.org/ec-code/1.1.1.27
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
type: Reaction
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
modifier: MODEL1310110002#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_bb478c3a_4392_45d0_8969_eae61ed6443f
name: PGM3
is encoded by: hsa:5238
constant: false
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: B4DX94

metaR GTHRDt
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
reactant: MODEL1310110002#
name: Glutathione transport into mitochondria
fast: false
product: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_7fda3ba1_6e5d_4b53_acb9_94147beec3d4
initial amount: NaN
type: Species
initial concentration: NaN
name: GALNT8
constant: false
is: Q9NY28
is encoded by: hsa:26290
has only substance units: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_68437efa_e519_4102_be34_cf4479f2f1f2
is: SBO:0000252
name: NDUFS4
type: Species
is encoded by: hsa:4724
is: O43181
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR ABUTD
fast: false
name: Aminobutyraldehyde dehydrogenase
modifier: MODEL1310110002#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110002#
is described by: ECO:0000269
reversible: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.2.1.3

metaR LEUKTRB4t
is described by: ECO:0000000
type: Reaction
name: leukotriene B4 transport
kinetic law: MODEL1310110002#
product: MODEL1310110002#
fast: false
reversible: true
reactant: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR r2112
type: Reaction
reversible: true
reactant: MODEL1310110002#
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaM dtmp c
is: C00364
is: HMDB01227
initial amount: NaN
constant: false
notes: FORMULA: C10H13N2O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: dTMP
is: CHEBI:26999
has only substance units: false
type: Species

metaM mi145p c
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C6H9O15P3 CHARGE: -6 INCHI: InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-6/t1-,2+,3+,4-,5-,6-/m1/s1 EHMN_ABBREVIATION: C01245
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:203600
constant: false
boundary condition: false
is: HMDB01498
name: 1D-myo-inositol 1,4,5-trisphosphate(6-)

metaR GHMT2r
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.1.2.1
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (6470.1) or (6470.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
fast: false
modifier: MODEL1310110002#
is: SBO:0000176
type: Reaction
name: glycine hydroxymethyltransferase, reversible
is described by: ECO:0000269
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_g
initial amount: NaN
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:61648
type: Species
initial concentration: 1.0
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
name: Type IIIAb

metaR ARGLYSex
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000269
name: Arginine/Lysine exchanger (Arg in)
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (9057.1 and 6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770310 NOTES:SAB see PMID 14770310
reversible: false
is: SBO:0000185
fast: false
reactant: MODEL1310110002#
modifier: MODEL1310110002#

metaM L2aadp m
boundary condition: false
is: SBO:0000247
name: L-2-aminoadipate(1-)
initial concentration: 1.0
type: Species
is: HMDB00510
constant: false
is: CHEBI:58672
initial amount: NaN
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
has only substance units: false

metaR r1435
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110002#
type: Reaction
name: Transport reaction
is described by: ECO:0000000
reversible: false
fast: false
is: SBO:0000185
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#

metaR r0339
is version of: http://identifiers.org/ec-code/3.1.2.22
type: Reaction
kinetic law: MODEL1310110002#
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is version of: http://identifiers.org/ec-code/2.3.1.65
reversible: false
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110002#
is: SBO:0000176
fast: false

metaR r0178
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
reactant: MODEL1310110002#
is: SBO:0000176
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
type: Reaction
modifier: MODEL1310110002#
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.5.1.21

http://identifiers.org/biomodels.db/MODEL1310110002#_8e0415a5_4775_45d0_ac75_e9f0965a99bf
initial concentration: NaN
name: _AI091231_1_c
has only substance units: false
is encoded by: hsa:AI091231
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaR S6T17g
reactant: MODEL1310110002#
reversible: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#
modifier: MODEL1310110002#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR GLYC St
is: SBO:0000185
name: L-glycerate export
reversible: false
reactant: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:9604805 NOTES:
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_e026e87b_8104_4180_b65f_fa2fd6074398
initial concentration: NaN
initial amount: NaN
name: LTA4H
constant: false
is: P09960
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4048
has only substance units: false
type: Species

metaR AG13T13g
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
modifier: MODEL1310110002#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

metaR r0973
is: SBO:0000185
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110002#
name: Facilitated diffusion
type: Reaction
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_590dc710_782e_4712_8c50_17a6f0397edb
has only substance units: false
constant: false
is: P49619
is encoded by: hsa:1608
name: DGKG
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_127a1477_f2a7_4123_adab_40a9f7b316a3
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:197257
name: LDHD
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR r2113
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
type: Reaction
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000000
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_22b855b2_0ca4_4ffd_8e41_f967c3f8d691
is: O94903
is encoded by: hsa:11212
type: Species
name: PROSC
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_06b8fb0f_f2c6_4a91_a51c_45c5286129fb
constant: false
initial concentration: NaN
is encoded by: hsa:284129
has only substance units: false
is: SBO:0000252
name: SLC26A11
initial amount: NaN
type: Species
is: Q86WA9
boundary condition: true

metaM dad 2 c
notes: FORMULA: C10H13N5O3 CHARGE: 0 INCHI: InChI=1S/C10H13N5O3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(17)6(2-16)18-7/h3-7,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00431
is: HMDB00101
initial concentration: 1.0
type: Species
is: CHEBI:17256
name: 2-deoxyadenosine
initial amount: NaN
boundary condition: false
is: SBO:0000247
has only substance units: false
constant: false

metaR ADK3
reactant: MODEL1310110002#
name: adentylate kinase (GTP)
is version of: http://identifiers.org/ec-code/2.7.4.3
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
fast: false
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110002#_aa9c6467_f789_472a_8b47_db157d4b1678
is: O43674
is encoded by: hsa:4711
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
name: NDUFB5
boundary condition: true
type: Species
initial concentration: NaN

metaM apoC Lys c
initial amount: NaN
name: Apocarboxylase (Lys residue)
boundary condition: false
is: CHEBI:32551
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00182
type: Species
notes: FORMULA: C6H13N2OX CHARGE: 0
initial concentration: 1.0

metaM srtn c
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: serotonin(1+)
is: CHEBI:350546
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
type: Species
has only substance units: false
boundary condition: false
is: HMDB00259
constant: false

metaR ICDHy
reactant: MODEL1310110002#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (3417.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:10521434 NOTES:Two reactions (ICDH1 and ICDH2) for isocitrate dehydrogenase
reversible: false
fast: false
name: isocitrate dehydrogenase (NADP)

metaM glyc3p x
constant: false
is: SBO:0000247
is: C00093
is: HMDB00126
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: CHEBI:57597
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: Glycerol 3-phosphate
initial concentration: 1.0

metaR NADH2 u10m
modifier: MODEL1310110002#
reactant: MODEL1310110002#
name: NADH dehydrogenase, mitochondrial
reversible: false
is version of: http://identifiers.org/ec-code/1.6.99.3
notes: GENE_ASSOCIATION: (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (4694.1) and (374291.1) and (4728.1) and (4717.1) and (4731.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (4722.1) and (7991.1) and (4541.1) and (4539.1) and (4712.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4706.1) and (4535.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (4712.2) and (4717.1) and (4705.1) and (4725.1) and (4716.1) and (4537.1) and (7991.1) and (4722.1) and (4541.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (126328.1) and (4711.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4729.1) and (4540.1) or (4715.1) and (4720.1) and (4719.1) and (4700.1) and (55967.1) and (4709.1) and (4710.1) and (4726.1) and (4718.1) and (4696.1) and (4694.1) and (374291.1) and (4728.1) and (7991.2) and (4717.1) and (4705.1) and (4725.1) and (4537.1) and (4716.1) and (4722.1) and (4541.1) and (4712.1) and (4539.1) and (4707.1) and (4701.1) and (4723.1) and (4698.1) and (4538.1) and (4697.1) and (51079.1) and (4714.1) and (4704.1) and (4711.1) and (126328.1) and (4724.1) and (4713.1) and (4536.1) and (4695.1) and (4702.1) and (4708.1) and (4535.1) and (4731.2) and (4706.1) and (4540.1) and (4729.1) or (4715.1) and (4720.1) and (4719.1) and (55967.1) and (4700.1) and (4709.1) and (4710.1) and (4726.1) and (4696.1) and (4718.1) and (374291.1) and (4694.1) and (4728.1) and (4712.2) and (4717.1) and (4731.1) and (…
is: SBO:0000185
is version of: http://identifiers.org/ec-code/1.6.5.3
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110002#
product: MODEL1310110002#
fast: false

metaR ACACT7p
reversible: false
name: acetyl-CoA acyltransferase (tetradecanoyl-CoA), peroxisomal
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
type: Reaction
reactant: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110002#
product: MODEL1310110002#
fast: false

metaR FRDPtcr
product: MODEL1310110002#
reactant: MODEL1310110002#
name: transport of Farnesyl diphosphate into the endoplasmic reticulum
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: required for cholesterol synthesis in E.R. NOTES:required for cholesterol synthesis in E.R.
is described by: ECO:0000134
reversible: true
type: Reaction
is: SBO:0000185
fast: false

metaM 34hpp c
initial amount: NaN
boundary condition: false
is: HMDB00707
name: 3-(4-hydroxyphenyl)pyruvate
has only substance units: false
is: SBO:0000247
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: CHEBI:36242
constant: false
type: Species
initial concentration: 1.0

metaR THYOXt
is: SBO:0000185
notes: GENE_ASSOCIATION: (53919.1) or (6579.1) or (28231.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
product: MODEL1310110002#
is described by: ECO:0000269
reversible: true
fast: false
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
name: T4 transport via bicarbonate countertransport

metaR B3GNT31g
product: MODEL1310110002#
kinetic law: MODEL1310110002#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is: SBO:0000176
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110002#
reversible: false
reactant: MODEL1310110002#
is described by: ECO:0000269
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_722a225f_2cdf_41d5_9367_6866b70f839c
name: CA1
type: Species
is: SBO:0000252
is: P00915
constant: false
is encoded by: hsa:759
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaR r0974
kinetic law: MODEL1310110002#
reversible: true
is: SBO:0000185
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10334869,PMID:12603856,PMID:17024033,PMID:9516450 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110002#
name: Active transport

http://identifiers.org/biomodels.db/MODEL1310110002#_b9444fa1_3fed_459c_879c_2e04a86906ef
name: DHFR
is encoded by: hsa:1719
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: P00374
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_af985422_7e46_48f0_8b7c_d38f6db9e6cf
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:1339
initial concentration: NaN
initial amount: NaN
is: Q02221
has only substance units: false
boundary condition: true
name: COX6A2

metaM 34hpp e
name: 3-(4-hydroxyphenyl)pyruvate
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:36242
boundary condition: false
has only substance units: false
is: HMDB00707
initial concentration: 1.0
type: Species

metaR ARABR
kinetic law: MODEL1310110002#
type: Reaction
is: SBO:0000176
product: MODEL1310110002#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.21
is version of: http://identifiers.org/ec-code/1.1.1.2
name: arabinose reductase
reactant: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110002#_96ee939b_bd4e_4622_a6c6_d8a7422124fc
boundary condition: true
initial amount: NaN
type: Species
has part: Q92536
is encoded by: hsa:9057
is: SBO:0000297
initial concentration: NaN
has only substance units: false
constant: false
name: SLC3A2:SLC7A6

metaR FRDPtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12121718,PMID:12840657,PMID:14713247 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). See also Krisans (PMID: 14713247, PMID: 12121718) for synthesis of cholesterol pathway (why FRDP needs to be transported between ER and peroxisome) NJ
type: Reaction
kinetic law: MODEL1310110002#
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110002#
reversible: true
fast: false
reactant: MODEL1310110002#

metaM ksi pre11 g
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
is: SBO:0000247
type: Species
name: keratan sulfate I biosynthesis, precursor 11
initial concentration: 1.0
is: CHEBI:28067

metaR r2114
kinetic law: MODEL1310110002#
fast: false
is: SBO:0000185
modifier: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110002#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
product: MODEL1310110002#

metaM estrone c
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
name: estrone
type: Species
constant: false
is: CHEBI:17263
is: HMDB00145
notes: FORMULA: C18H22O2 CHARGE: 0 INCHI: InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1 EHMN_ABBREVIATION: C00468
is: SBO:0000247

metaR NAIt
fast: false
modifier: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110002#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11034615,PMID:12679487,PMID:12748858,PMID:15546855,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:NCD
kinetic law: MODEL1310110002#
product: MODEL1310110002#
name: Na+ / iodide cotransport

metaM sebcoa x
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: sebacoylcoa
type: Species
constant: false
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
is: http://identifiers.org/pubchem.compound/16019966

http://identifiers.org/biomodels.db/MODEL1310110002#_19d4a758_6c27_489b_91a5_7ba38f8e45ce
name: ST20
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: Q9HBF5
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:400410

metaM ksi pre27 g
is: C00130
boundary condition: false
is: HMDB00175
constant: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 27
is: CHEBI:58053
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C205H328N14O171S8X CHARGE: -9

http://identifiers.org/biomodels.db/MODEL1310110002#_8d59eace_5db9_42ca_aa7d_b1db2434f7a7
boundary condition: true
is encoded by: hsa:2180
name: ACSL1
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: P33121
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_acgalfucgalacgalfucgalacglcgal14acglcgalgluside_hs_e
is: CHEBI:15347
constant: false
name: Type IIIAb
notes: FORMULA: C92H158N5O55FULLRCO CHARGE: 0
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB01659
is: SBO:0000247

metaR AG13T7g
type: Reaction
fast: false
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.149
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176

metaM fru c
is: C00095
is: CHEBI:15824
constant: false
initial concentration: 1.0
type: Species
is: HMDB00660
boundary condition: false
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
initial amount: NaN
has only substance units: false
name: D-Fructose
is: SBO:0000247

metaM h2o2 x
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
constant: false
has only substance units: false
is: HMDB03125
boundary condition: false
is: C00027
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: Hydrogen peroxide

http://identifiers.org/biomodels.db/MODEL1310110002#_50771dd4_07e5_4152_9a22_c2436b0bf830
initial amount: NaN
boundary condition: true
is encoded by: hsa:55753
is: SBO:0000252
is: Q9ULD0
constant: false
has only substance units: false
type: Species
initial concentration: NaN
name: OGDHL

metaR CDPDAGtm
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ
fast: false
name: intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110002#
product: MODEL1310110002#

metaM q10 m
is: SBO:0000247
initial amount: NaN
boundary condition: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: HMDB01072
has only substance units: false
initial concentration: 1.0
type: Species
is: CHEBI:46245
constant: false
name: ubiquinone-10

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaR ADSS
reversible: false
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
type: Reaction
modifier: MODEL1310110002#
fast: false
product: MODEL1310110002#
is: SBO:0000176
name: adenylosuccinate synthase
is described by: ECO:0000134
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/6.3.4.4
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_0a8fb089_2d1a_4719_a721_7e7a07304685
name: ACP6
is encoded by: hsa:51205
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is: Q9NPH0
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaM CE5117 m
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:57923
initial concentration: 1.0
name: (3E,5Z,8Z)-tetradecatrienoyl-CoA
has only substance units: false
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-14,22-24,28-30,34,45-46H,4-7,10,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5117
is: SBO:0000247
type: Species

metaR CYTK2n
name: cytidylate kinase (dCMP),nuclear
reactant: MODEL1310110002#
is: SBO:0000176
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110002#
reversible: true
modifier: MODEL1310110002#
is described by: ECO:0000269

metaR r2115
reversible: true
reactant: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110002#
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_9ae95dee_1c42_4bd4_a4d3_6b7d0672097b
is: SBO:0000252
is encoded by: hsa:8706
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: B3GALNT1
type: Species
is: B3KTQ4
constant: false
boundary condition: true

metaR r1010
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110002#
is: SBO:0000185
name: Postulated transport reaction
product: MODEL1310110002#

metaR 4MOPte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000185
product: MODEL1310110002#
type: Reaction
name: Transport of 4-methyl-2-oxopentanoate
fast: false
reactant: MODEL1310110002#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_9dc6ff52_19cf_4961_9155_52ad7392e75f
initial amount: NaN
has only substance units: false
is encoded by: hsa:5290
name: PIK3CA
constant: false
initial concentration: NaN
is: SBO:0000252
is: P42336
type: Species
boundary condition: true

metaM srtn e
notes: FORMULA: C10H13N2O CHARGE: 1 INCHI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00533 EHMN_ABBREVIATION: C00780
has only substance units: false
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB00259
is: CHEBI:350546
name: serotonin(1+)
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_adf4c7fb_c163_4cdd_82eb_303642ff8d26
is: P17568
has only substance units: false
boundary condition: true
is encoded by: hsa:4713
type: Species
constant: false
name: NDUFB7
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_5b189511_13f0_4dea_b183_77f3ad6bc48b
constant: false
is encoded by: hsa:195814
initial amount: NaN
initial concentration: NaN
has only substance units: false
name: SDR16C5
is: B3KT84
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_8767e225_99b9_4402_b29e_a649501e023a
constant: false
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:60482
initial amount: NaN
name: SLC5A7
is: Q9GZV3

metaR RE0915E
name: RE0915
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.1
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:

metaR ARACHt
reactant: MODEL1310110002#
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: fatty acid transport via diffusion

metaM ksii core4 pre9 g
constant: false
is: CHEBI:28067
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
name: keratan sulfate II biosynthesis, precursor 9
is: SBO:0000247

metaR MI1PP
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
kinetic law: MODEL1310110002#
is described by: ECO:0000269
modifier: MODEL1310110002#
is: SBO:0000176
reversible: false
name: myo-inositol 1-phosphatase
product: MODEL1310110002#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.25
reactant: MODEL1310110002#

metaM HC02208 e
initial concentration: 1.0
is: CHEBI:27696
name: prostaglandin-d1
constant: false
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
boundary condition: false
is: SBO:0000247

metaM fru e
is: CHEBI:15824
boundary condition: false
is: SBO:0000247
is: HMDB00660
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00097 EHMN_ABBREVIATION: C00095
name: D-Fructose
has only substance units: false
initial amount: NaN
is: C00095

metaM udpacgal l
is: HMDB00304
name: UDP-N-acetyl-D-galactosamine(2-)
is: SBO:0000247
initial amount: NaN
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:57847
constant: false

metaR OMHPALTD
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaM retinol c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: HMDB00305
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
name: retinol
initial concentration: 1.0
constant: false
initial amount: NaN
is: CHEBI:50211

metaM amet r
initial amount: NaN
notes: FORMULA: C15H23N6O5S CHARGE: 1 INCHI: InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/p+1/t7-,8+,10+,11+,14+,27?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00029 EHMN_ABBREVIATION: C00019
initial concentration: 1.0
type: Species
has only substance units: false
name: S-adenosyl-L-methionine
is: HMDB01185
constant: false
boundary condition: false
is: CHEBI:15414
is: SBO:0000247

metaM crn x
boundary condition: false
initial amount: NaN
name: L-Carnitine
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
has only substance units: false
is: SBO:0000247
is: HMDB00062
is: C00318
type: Species
initial concentration: 1.0
is: CHEBI:16347

http://identifiers.org/biomodels.db/MODEL1310110002#_fff8897c_00c1_4412_b53f_6edd1fded1cd
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:4830
is: SBO:0000252
boundary condition: true
name: NME1

metaR r1019
product: MODEL1310110002#
type: Reaction
name: Postulated transport reaction
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_28971eeb_a2dc_4b2a_9726_c3602ccad7e8
has only substance units: false
boundary condition: true
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:2348
name: FOLR1
initial concentration: NaN
type: Species

metaR PMANM
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
modifier: MODEL1310110002#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/5.4.2.2
type: Reaction
kinetic law: MODEL1310110002#
product: MODEL1310110002#
fast: false
is: SBO:0000176
name: phosphomannomutase
is version of: http://identifiers.org/ec-code/5.4.2.8

metaM galgalgalthcrm hs c
has only substance units: false
constant: false
initial amount: NaN
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00143
is: CHEBI:12936

http://identifiers.org/biomodels.db/MODEL1310110002#_1171c84e_50a6_4167_a0be_16aba561cd3f
constant: false
is: SBO:0000252
is: Q96G03
is encoded by: hsa:55276
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: PGM2
initial concentration: NaN

metaR CHOLESTle
is version of: http://identifiers.org/ec-code/3.1.1.13
is: SBO:0000176
modifier: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (3988.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110002#
is described by: ECO:0000134
reversible: false
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
name: hydrolysis of cholesterol ester by cholesterol esterase

metaR FAOXC163GC142m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)gm
type: Reaction

metaM g6p c
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
name: D-Glucose 6-phosphate
constant: false
initial amount: NaN
is: CHEBI:61548
boundary condition: false
is: SBO:0000247
is: C00092
has only substance units: false
type: Species
is: HMDB01401

metaR r2116
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
product: MODEL1310110002#
type: Reaction

metaR RE2999M
kinetic law: MODEL1310110002#
type: Reaction
is: SBO:0000176
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE2999
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/5.3.3.8
reversible: true
fast: false
reactant: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000000

metaM ksi pre2 g
boundary condition: false
constant: false
notes: FORMULA: C87H142N6O62X CHARGE: -1
is: C00130
is: CHEBI:58053
is: HMDB00175
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 2

metaR r0390
name: Isomaltose 6-alpha-D-glucanohydrolase Starch and sucrose metabolism EC:3.2.1.10
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: PMID:17194452 NOTES:
product: MODEL1310110002#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
reversible: true

metaR r1544
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_f5d1f1b9_9e11_41e0_b832_85a8c3da1dba
type: Species
is encoded by: hsa:2687
has only substance units: false
name: GGT5
boundary condition: true
initial amount: NaN
is: P36269
is: SBO:0000252
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_0acb25f9_75a6_466e_a191_03eb5ba0bcb0
initial amount: NaN
is encoded by: hsa:151531
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is: O95045
constant: false
is: SBO:0000252
name: UPP2

metaR DNDPt9m
name: dADP transport via dTDP antiport
modifier: MODEL1310110002#
reversible: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaR 7DHCHSTEROLtr
is: SBO:0000185
reversible: true
name: cholesterol precursor intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
kinetic law: MODEL1310110002#
fast: false
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#

metaM q10 c
name: ubiquinone-10
is: HMDB01072
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: SBO:0000247
is: CHEBI:46245
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_9189e0de_8a3e_4b73_9bb6_8f0fd503af53
boundary condition: true
is: P04075
is: SBO:0000252
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: ALDOA
is encoded by: hsa:226

metaM dhbpt c
initial amount: NaN
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: HMDB00038
initial concentration: 1.0
type: Species
is: CHEBI:20680
constant: false
name: 6,7-dihydrobiopterin
has only substance units: false
is: SBO:0000247

metaR FAOXC6DCC4DCx
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6DC-->C4DC)x
type: Reaction

metaR MMCDm
kinetic law: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.9
notes: GENE_ASSOCIATION: (23417.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.1.1.9 Confidence Level: 1 AUTHORS: PMID:12123667,PMID:12955715 NOTES:JLR mitochondrial isoform - NCD
modifier: MODEL1310110002#
fast: false
reversible: false
reactant: MODEL1310110002#
name: Methylmalonyl-CoA decarboxylase, mitochondrial
type: Reaction
is described by: ECO:0000212
product: MODEL1310110002#

metaR DCYTt
fast: false
reactant: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110002#
type: Reaction
name: deoxycytidine transport via diffusion

metaM hdd2coa x
is: HMDB03945
is: CHEBI:61526
constant: false
boundary condition: false
initial amount: NaN
name: (E)-hexadec-2-enoyl-CoA(4-)
initial concentration: 1.0
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h16-17,24-26,30-32,36,47-48H,4-15,18-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b17-16+/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_2f9c39a7_6200_46df_b7d2_d4b8f7b7eb9c
type: Species
has only substance units: false
initial concentration: NaN
is: O15245
is encoded by: hsa:6580
initial amount: NaN
name: SLC22A1
boundary condition: true
is: SBO:0000252
constant: false

metaM CE4790 m
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
type: Species
is: CHEBI:57923
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_002ce7e0_dc1e_45f2_8f28_61b151661620
is: Q11203
boundary condition: true
initial concentration: NaN
name: ST3GAL3
initial amount: NaN
has only substance units: false
is encoded by: hsa:6487
constant: false
is: SBO:0000252
type: Species

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaR r2117
is: SBO:0000185
modifier: MODEL1310110002#
reversible: true
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaM gmp g
is: HMDB01397
name: GMP(3-)
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:58115
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species

metaR DNDPt28m
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: false
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dCDP transport via dGDP antiport
product: MODEL1310110002#
is described by: ECO:0000269
is: SBO:0000185
fast: false

metaR r0391
product: MODEL1310110002#
name: Nicotinate D-ribonucleotide:pyrophosphate phosphoribosyltransferase Nicotinate and nicotinamide metabolism EC:2.4.2.11
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 2.4.2.11 Confidence Level: 0 AUTHORS: PMID:17604275 NOTES:
reversible: true
reactant: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
type: Reaction
fast: false
is described by: ECO:0000000

metaM cdp e
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
has only substance units: false
type: Species
is: HMDB01546
constant: false
is: CHEBI:58069
initial amount: NaN
name: CDP(3-)
boundary condition: false

metaR PIter
is described by: ECO:0000212
notes: GENE_ASSOCIATION: (2544.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11879177 NOTES:NCD
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
name: phosphate transport, endoplasmic reticulum
fast: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110002#
reversible: true
product: MODEL1310110002#

metaM 2mbcoa m
is: HMDB01041
type: Species
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:57336
initial amount: NaN
name: 2-methylbutanoyl-CoA(4-)
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_68aa6d65_6880_4e80_a6c2_edd121ad6d02
type: Species
has only substance units: false
name: _FLJ44968_1_m
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:FLJ44968
constant: false

metaR r1546
is: SBO:0000185
reversible: true
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110002#
product: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
type: Reaction
is described by: ECO:0000000

metaR GCC2bim
fast: false
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is described by: ECO:0000269
name: glycine-cleavage system (lipoamide) irreversible, mitochondrial
is version of: http://identifiers.org/ec-code/1.4.4.2
is version of: http://identifiers.org/ec-code/1.8.1.4
type: Reaction
modifier: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.10
reversible: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#

metaM dc2coa m
boundary condition: false
is: CHEBI:61406
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 EHMN_ABBREVIATION: C05275
name: trans-Dec-2-enoyl-CoA
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
type: Species

metaR NRPPHRtu
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110002#
name: Norepinephrine uniport
modifier: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
product: MODEL1310110002#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_e963e14a_850c_4954_b945_d5786373e6be
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: _AA021081_1_r
is encoded by: hsa:AA021081
has only substance units: false

metaM HC02208 c
is: SBO:0000247
name: prostaglandin-d1
is: CHEBI:27696
has only substance units: false
constant: false
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaM g2m8masn r
constant: false
initial amount: NaN
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
notes: FORMULA: C82H137N2O65X CHARGE: 0
type: Species
is: C05874
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_99a304a9_8ec9_4fa6_9af3_02ced2227fb4
is: SBO:0000252
is encoded by: hsa:53947
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: Q9NPC4
initial concentration: NaN
constant: false
name: A4GALT

metaM L2aadp c
constant: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: HMDB00510
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58672
boundary condition: false
name: L-2-aminoadipate(1-)
type: Species
is: SBO:0000247

metaR r2118
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110002#

metaM galgalgalthcrm hs e
type: Species
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer
boundary condition: false
is: CHEBI:0
initial amount: NaN
constant: false
notes: FORMULA: C54H96NO32FULLRCO CHARGE: 0
has only substance units: false
is: HMDB00143
is: C00124
is: SBO:0000247
initial concentration: 1.0

metaR EX dgchol LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Chenodeoxyglycocholate exchange
type: Reaction

metaM glcur l
initial amount: NaN
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: D-glucuronate
is: HMDB00127
constant: false
is: CHEBI:15748
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191

http://identifiers.org/biomodels.db/MODEL1310110002#_81dd766b_a6ee_48af_b41f_5dc4717f05bb
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:765
is: SBO:0000252
boundary condition: true
name: CA6
is: Q5FC00

metaR r0392
reversible: true
is: SBO:0000176
product: MODEL1310110002#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
type: Reaction
reactant: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
fast: false

metaR SBTR
is: SBO:0000176
modifier: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
product: MODEL1310110002#
name: D-sorbitol reductase
fast: false
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.2
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21

metaM dtmp e
is: HMDB01227
has only substance units: false
type: Species
notes: FORMULA: C10H13N2O8P CHARGE: -2 INCHI: InChI=1S/C10H15N2O8P/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)/p-2/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00308 EHMN_ABBREVIATION: C00364
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: dTMP(2-)
is: CHEBI:26999
constant: false
initial concentration: 1.0

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM acald e
initial concentration: 1.0
boundary condition: false
is: CHEBI:15343
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial amount: NaN
name: acetaldehyde
constant: false
is: HMDB00990

metaM pmtcrn x
initial amount: NaN
is: CHEBI:17490
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: HMDB00222
name: L-palmitoylcarnitine
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0

metaM chol r
is: SBO:0000247
type: Species
is: HMDB00097
has only substance units: false
name: choline
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
constant: false
is: CHEBI:15354
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_beed65ac_92be_43f9_bf7a_cc83137628d1
boundary condition: true
is encoded by: hsa:1119
name: CHKA
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is: P35790
has only substance units: false
type: Species

metaR r1547
kinetic law: MODEL1310110002#
fast: false
product: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110002#

metaM chtn e
constant: false
is: SBO:0000247
is: CHEBI:17029
initial concentration: 1.0
initial amount: NaN
name: chitin
notes: FORMULA: C24H41N3O16 CHARGE: 0 INCHI: InChI=1S/C24H41N3O16/c1-7(31)25-13-18(36)20(11(5-29)39-22(13)38)42-24-15(27-9(3)33)19(37)21(12(6-30)41-24)43-23-14(26-8(2)32)17(35)16(34)10(4-28)40-23/h10-24,28-30,34-38H,4-6H2,1-3H3,(H,25,31)(H,26,32)(H,27,33)/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+,24+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02118
type: Species
is: HMDB03362
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_d5b4cb4b_d4cd_456c_9d88_e5d02485d1f3
is: E7EPT3
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
name: ALDH7A1
is encoded by: hsa:501
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_d85aa00f_dbc2_4249_a9e7_7093bcb2ef87
initial concentration: NaN
name: _2544_1_c
constant: false
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:2544
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_b6feeeb5_d848_409f_b08d_593c69ce040d
is: O14561
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4706
initial concentration: NaN
constant: false
name: NDUFAB1
boundary condition: true

metaR GDPFUCtg
reactant: MODEL1310110002#
name: GDPFuc Golgi transport via CMP antiport
is described by: ECO:0000269
product: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
reversible: true

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

metaM 3ohdcoa x
is: HMDB06402
type: Species
name: 3-oxopalmitoyl-CoA(4-)
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:57349
constant: false

metaR r2119
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
modifier: MODEL1310110002#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110002#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_37eed4b5_feca_4724_8aca_c482179b7dd8
is: SBO:0000252
boundary condition: true
has only substance units: false
name: PDHX
constant: false
type: Species
initial concentration: NaN
is: O00330
initial amount: NaN
is encoded by: hsa:8050

metaR S23T2g
is described by: ECO:0000000
modifier: MODEL1310110002#
reversible: false
kinetic law: MODEL1310110002#
name: beta-galactoside alpha-2,3-sialyltransferase (core 2)
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.4

metaR r0680
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:
reactant: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.137
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
modifier: MODEL1310110002#
fast: false
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110002#_metaR_EX_galgalfucfucgalacglcgalacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1 exchange
type: Reaction

metaR ALAtN1
reversible: true
is described by: ECO:0000269
name: Alanine transport (Na, H coupled)
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_7e0942da_4e59_4ec1_850c_4856c72b94e6
is: O95992
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: CH25H
has only substance units: false
is encoded by: hsa:9023
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_7e4ed2d8_8564_41f6_b140_e1930f5b18c8
is: SBO:0000252
name: NMNAT3
initial amount: NaN
boundary condition: true
is: Q96T66
has only substance units: false
type: Species
is encoded by: hsa:349565
initial concentration: NaN
constant: false

metaM cdp c
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: CHEBI:58069
is: HMDB01546
has only substance units: false
initial amount: NaN
is: C00112
type: Species
name: CDP
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_918e20f7_e9f6_4c64_b801_82e54c9d211f
is encoded by: hsa:23236
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
is: Q9NQ66
name: PLCB1
type: Species

metaR S6TASE25ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.18
name: galactose-6-sulfate sulfatase, lysosomal
product: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
modifier: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110002#

metaR NACHEXA7ly
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110002#
is: SBO:0000176
product: MODEL1310110002#
fast: false
reversible: false
name: beta-N-acetylhexosaminidase A, lysosomal
is described by: ECO:0000000
modifier: MODEL1310110002#

metaR EX galacglcgalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-GlcNAc-Gal globoside (homo sapiens) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_2e574cb1_6d78_4adf_851a_e11492d1bc86
is encoded by: hsa:121278
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: TPH2
is: Q8IWU9
has only substance units: false

metaR r0393
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
is: SBO:0000176
product: MODEL1310110002#
reversible: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.1.74
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:

metaR RE2079R
type: Reaction
kinetic law: MODEL1310110002#
name: RE2079
is described by: ECO:0000000
product: MODEL1310110002#
fast: false
is: SBO:0000176
reactant: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:

metaR 5ADTSTSTERONEtr
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: 5 alpha dihydrotesterone intracellular transport
reversible: true
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaM h2o2 m
is: HMDB03125
is: SBO:0000247
is: C00027
type: Species
constant: false
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
has only substance units: false
initial amount: NaN
name: Hydrogen peroxide
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_dc22b41f_0193_4cc3_9bd3_18a76d940b56
initial concentration: NaN
initial amount: NaN
name: GLRX
is: SBO:0000252
boundary condition: true
is encoded by: hsa:2745
type: Species
has only substance units: false
is: P35754
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_e1b5aebb_0de6_43d6_b00f_b0305b69d1a7
initial amount: NaN
is encoded by: hsa:6514
has only substance units: false
constant: false
is: P11168
name: SLC2A2
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR DSAT
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
name: dihydrosphingosine N-acyltransferase
fast: false
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ

http://identifiers.org/biomodels.db/MODEL1310110002#_30caa585_909e_4666_8fb5_84f81b1fc9a7
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:AU149534
name: _AU149534_1_m

metaM nm2masn g
is: C05884
type: Species
boundary condition: false
notes: FORMULA: C42H70N3O30X CHARGE: 0
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
constant: false
initial amount: NaN

metaR DOLPGT2 Uer
reversible: false
product: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
kinetic law: MODEL1310110002#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
is: SBO:0000176
fast: false
reactant: MODEL1310110002#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.265
type: Reaction

metaR LEUTA
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
is: SBO:0000176
is described by: ECO:0000269
name: leucine transaminase
type: Reaction
product: MODEL1310110002#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_0749c59f_432c_48aa_a958_2545a0906597
is: P47989
initial concentration: NaN
name: XDH
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false
is encoded by: hsa:7498

metaR CHOLATEt
reversible: true
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:9007731,PMID:9334206 NOTES:NJ
kinetic law: MODEL1310110002#
name: cholate transport via bicarbonate countertransport
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110002#
is: SBO:0000185

metaM xol7ah2 m
name: 5beta-cholestane-3alpha,7alpha-diol
is: HMDB06893
initial concentration: 1.0
is: CHEBI:28047
boundary condition: false
has only substance units: false
notes: FORMULA: C27H48O2 CHARGE: 0 INCHI: InChI=1S/C27H48O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-25,28-29H,6-16H2,1-5H3/t18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01461 EHMN_ABBREVIATION: C05452
type: Species
constant: false
is: SBO:0000247
initial amount: NaN

metaR FAOXC163C164Gm
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

metaR PPCOAOm
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
reversible: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
is: SBO:0000176
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM acald c
is: SBO:0000247
is: HMDB00990
is: CHEBI:15343
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
initial concentration: 1.0
type: Species
boundary condition: false
name: acetaldehyde
constant: false
has only substance units: false
initial amount: NaN

metaR r1548
reversible: true
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_8b1c52bb_52da_40e4_87d5_50eccb890357
name: AKR1A1
is: SBO:0000252
has only substance units: false
is: P14550
is encoded by: hsa:10327
constant: false
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN

metaR r0394
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
reversible: true
is described by: ECO:0000000
product: MODEL1310110002#

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

metaM mi1p D c
constant: false
boundary condition: false
is: CHEBI:58433
has only substance units: false
is: HMDB02985
name: 1D-myo-inositol 1-phosphate(2-)
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2(8)4(10)6(5(11)3(1)9)15-16(12,13)14/h1-11H,(H2,12,13,14)/p-2/t1-,2-,3+,4-,5-,6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00698
type: Species
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_fe581a23_0480_46a6_8abd_be4c4ece12b0
type: Species
is: P56181
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4731
has only substance units: false
name: NDUFV3
constant: false

metaM thyox L e
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB00248
initial amount: NaN
constant: false
is: CHEBI:18332
name: L-thyroxine
notes: FORMULA: C15H11I4NO4 CHARGE: 0 INCHI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00849
boundary condition: false
is: SBO:0000247

metaR G14T12g
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110002#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is described by: ECO:0000000
product: MODEL1310110002#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
is: SBO:0000176
fast: false

metaR r1088
fast: false
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reactant: MODEL1310110002#
name: Active transport
kinetic law: MODEL1310110002#
type: Reaction
product: MODEL1310110002#

metaM pmtcrn r
is: CHEBI:17490
name: L-palmitoylcarnitine
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
boundary condition: false
initial amount: NaN
is: HMDB00222
type: Species
has only substance units: false

metaR PNTOte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
fast: false
reversible: true
name: Transport of (R)-Pantothenate
is described by: ECO:0000134
product: MODEL1310110002#
is: SBO:0000185

metaR CHAT
is described by: ECO:0000269
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.6
name: Choline O-acetyltransferase
reversible: true
modifier: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ

http://identifiers.org/biomodels.db/MODEL1310110002#_a6a84d7f_01e6_49f2_a5d6_5939eb31c116
is: P00568
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
name: AK1
is encoded by: hsa:203
has only substance units: false

metaM h2o2 n
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
constant: false
is: CHEBI:16240
is: HMDB03125
boundary condition: false
initial concentration: 1.0
initial amount: NaN
name: hydrogen peroxide

http://identifiers.org/biomodels.db/MODEL1310110002#_fb53e5ba_60b6_49c2_8432_0d14968bfcd5
initial amount: NaN
is encoded by: hsa:AI620219
type: Species
name: _AI620219_1_c
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_754f9363_3eb8_4d5e_a212_1717b1b93a09
is encoded by: hsa:5232
name: PGK2
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
is: P07205
constant: false
boundary condition: true

metaR r1609
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_98e34758_4d6d_4e03_be12_d438e3d48c31
constant: false
has only substance units: false
is encoded by: hsa:AI926493
is: SBO:0000252
name: _AI926493_1_m
type: Species
initial concentration: NaN
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_da904713_9651_44a3_be19_9d6385eba25d
boundary condition: true
is: O15357
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:3636
name: INPPL1
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM sbcoa x
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: suberylcoa
is: http://identifiers.org/pubchem.compound/16019966
type: Species
initial concentration: 1.0

metaR r1549
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_925b889e_5aa8_4af1_a7e9_ac246e01a737
type: Species
is: O43916
is encoded by: hsa:8534
name: CHST1
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_990e637c_32f8_4430_8dae_595b8f6c0e87
initial concentration: NaN
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
name: NMNAT2
type: Species
is encoded by: hsa:23057

metaM glcur e
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:15748
name: D-glucuronate
is: HMDB00127
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR THRt4
is: SBO:0000185
product: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
is described by: ECO:0000269
reversible: false
type: Reaction
kinetic law: MODEL1310110002#
name: L-threonine via sodium symport
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (11254.1) or (81539.1) or (54407.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES:JLR

metaM arachd r
is: CHEBI:32395
initial concentration: 1.0
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: SBO:0000247
constant: false
is: HMDB01043
initial amount: NaN
type: Species
name: arachidonate
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_f1d0f347_724e_44c4_af01_25cc8dd874d2
has only substance units: false
constant: false
type: Species
is encoded by: hsa:4351
is: SBO:0000252
name: MPI
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: P34949

metaR HMGCOAtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14713247 NOTES:NCD
reversible: true
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaR r0443
fast: false
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
type: Reaction
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.42
is: SBO:0000176
reactant: MODEL1310110002#

metaR SPH1Pte
kinetic law: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
name: sph1p transport
fast: false
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#

metaM gmp c
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
is: C00144
name: GMP
is: HMDB01397
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:58115
constant: false
type: Species

metaR r0683
modifier: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
kinetic law: MODEL1310110002#
fast: false
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is: SBO:0000176
reversible: false

metaM crn r
is: CHEBI:16347
name: (R)-carnitine
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00062
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaR D3AIBTm
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110002#
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM

metaR LTC4CP
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 2 AUTHORS: PMID:12729612 NOTES:Converts leukotriene C4 (LTC4) to leukotriene F4 (LTF4). NJ
is: SBO:0000176
product: MODEL1310110002#
reactant: MODEL1310110002#
name: Leukotriene C4 carboxypeptidase
fast: false
kinetic law: MODEL1310110002#
type: Reaction

metaR KHte
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110002#
is described by: ECO:0000134
fast: false
name: KHte
is: SBO:0000185
type: Reaction
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_373c67f4_d779_45f3_8c04_8edf840a2aa8
boundary condition: true
type: Species
is: Q9NRX3
name: NDUFA4L2
initial amount: NaN
has only substance units: false
is encoded by: hsa:56901
is: SBO:0000252
constant: false
initial concentration: NaN

metaM chol n
notes: FORMULA: C5H14NO CHARGE: 1 INCHI: InChI=1S/C5H14NO/c1-6(2,3)4-5-7/h7H,4-5H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
initial concentration: 1.0
is: CHEBI:15354
initial amount: NaN
is: HMDB00097
has only substance units: false
name: choline
boundary condition: false
constant: false
is: SBO:0000247
type: Species

metaR HGNTOR
modifier: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110002#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.5
type: Reaction
is described by: ECO:0000269
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_c645eed9_0a8a_49e3_8677_1755cec32c65
is encoded by: hsa:9152
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
name: SLC6A5
is: Q9Y345
constant: false
initial amount: NaN

metaM ahcys c
is: CHEBI:16680
name: S-Adenosyl-L-homocysteine
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
type: Species
is: C00021
has only substance units: false
is: HMDB00939

metaM HC01118 r
constant: false
boundary condition: false
name: presqualene diphosphate(3-)
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:57310
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
is: SBO:0000247
initial concentration: 1.0

metaR CYSGLUexR
type: Reaction
reactant: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000304
name: L-cysteine/L-glutamine reversible exchanger
fast: false
kinetic law: MODEL1310110002#
is: SBO:0000185

metaM ps hs m
is: CHEBI:18303
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
name: ps_hs[m]
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_fbe1c7b9_a0c3_4c08_9c03_817750dedc31
boundary condition: true
has only substance units: false
name: _H53099_1_m
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:H53099
constant: false
initial amount: NaN

metaR N3Tg
reversible: false
modifier: MODEL1310110002#
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.122
fast: false
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
kinetic law: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction

metaR r1018
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
name: Transport reaction
fast: false

metaM f1a l
is: SBO:0000247
is: CHEBI:17151
has only substance units: false
boundary condition: false
notes: FORMULA: C22H37N2O15X CHARGE: 0
constant: false
initial amount: NaN
type: Species
name: F1alpha
is: HMDB02917
initial concentration: 1.0

metaM udpacgal g
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
type: Species
initial concentration: 1.0
is: CHEBI:57847
initial amount: NaN
constant: false
is: HMDB00304
is: SBO:0000247
boundary condition: false
has only substance units: false

metaM q10 e
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
name: ubiquinone-10
constant: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
is: SBO:0000247
is: CHEBI:46245
is: HMDB01072
initial concentration: 1.0

metaR ADSK
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.1.25
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
reversible: false
modifier: MODEL1310110002#
fast: false
name: adenylyl-sulfate kinase
is: SBO:0000176
reactant: MODEL1310110002#

metaM ddcacoa m
has only substance units: false
name: Dodecanoyl-CoA (n-C12:0CoA)
boundary condition: false
type: Species
is: CHEBI:57375
is: HMDB03571
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
is: C01832

http://identifiers.org/biomodels.db/MODEL1310110002#_f2ae6f4d_cebe_4f78_86b3_27dd48315763
has only substance units: false
constant: false
type: Species
has part: P08237
boundary condition: true
is: SBO:0000297
is encoded by: hsa:5213
initial concentration: NaN
initial amount: NaN
name: PFKM:PFKP

metaR r2335
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110002#
reversible: true
is: SBO:0000185
type: Reaction
is described by: ECO:0000000

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_a9cd7899_e2b1_43b0_a60b_6ea50f6e20c6
is: Q6FGQ4
name: PPT1
is: SBO:0000252
is encoded by: hsa:5538
type: Species
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_2eff8798_6227_415a_8088_08eec0d78021
is: SBO:0000252
name: _X63359_1_c
boundary condition: true
is encoded by: hsa:X63359
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
type: Species

metaR LYSOXp
kinetic law: MODEL1310110002#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
name: L-lysine oxidase, peroxisomal
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110002#
is: SBO:0000176
product: MODEL1310110002#

metaR PIK3
reversible: false
modifier: MODEL1310110002#
is: SBO:0000176
name: phosphatidylinositol 3-kinase
is version of: http://identifiers.org/ec-code/2.7.1.153
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.137
product: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.1.154
type: Reaction
kinetic law: MODEL1310110002#

metaM pyr m
initial concentration: 1.0
boundary condition: false
name: pyruvate
is: HMDB00243
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:15361
is: C00022
is: http://identifiers.org/pubchem.compound/3324
type: Species
constant: false
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022

metaM glcur r
has only substance units: false
type: Species
is: CHEBI:15748
initial amount: NaN
is: HMDB00127
constant: false
initial concentration: 1.0
is: SBO:0000247
name: D-glucuronate
boundary condition: false
notes: FORMULA: C6H9O7 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00182 EHMN_ABBREVIATION: C00191

metaR H2Oter
reactant: MODEL1310110002#
is described by: ECO:0000000
name: H2O endoplasmic reticulum transport
kinetic law: MODEL1310110002#
is: SBO:0000185
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_fb1b6de2_93ef_46f7_bab6_b56d8d405aae
initial amount: NaN
constant: false
is: E9PB82
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:3295
is: SBO:0000252
boundary condition: true
name: HSD17B4

metaR CORE2GTg
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110002#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.102
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110002#
modifier: MODEL1310110002#

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaR CHLtm
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
type: Reaction
reversible: true
name: choline transport via diffusion (cytosol to mitochondria)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
is: SBO:0000185

metaR r1605
product: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110002#
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110002#
is described by: ECO:0000000
type: Reaction

metaR EX asp D LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Aspartate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_fa9ed225_67be_4f44_be70_bb729a65285f
name: ADH1C
is: SBO:0000252
initial amount: NaN
is: P00326
is encoded by: hsa:126
boundary condition: true
constant: false
type: Species
has only substance units: false
initial concentration: NaN

metaR MALTSULtm
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
reversible: true
name: Malate:thiosulfate antiport, mitochondrial
is: SBO:0000185
modifier: MODEL1310110002#
product: MODEL1310110002#
fast: false

metaM chsterol m
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
is: CHEBI:16113
is: SBO:0000247
initial concentration: 1.0
name: cholesterol
constant: false
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
is: HMDB00067

metaM gluala e
name: 5-L-Glutamyl-L-alanine
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
is: C03740
initial concentration: 1.0
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/6503
boundary condition: false
is: HMDB06248
has only substance units: false
initial amount: NaN
constant: false
type: Species

metaR r2334
kinetic law: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110002#
fast: false
reversible: true
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
product: MODEL1310110002#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_40f8cb12_7483_4afb_8787_5be4668fc86d
has only substance units: false
is: SBO:0000252
name: IDH1
initial concentration: NaN
is encoded by: hsa:3417
is: O75874
initial amount: NaN
type: Species
boundary condition: true
constant: false

metaR RE1525M
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE1525
product: MODEL1310110002#
fast: false
is: SBO:0000176

metaR r0062
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Pyruvate metabolism EC Number: 3.1.2.1 Confidence Level: 0 AUTHORS: PMID:11322891,PMID:12545200,PMID:16951743,PMID:34392,PMID:6151837,PMID:7696329 NOTES:
product: MODEL1310110002#
name: Acetyl-CoA hydrolase Pyruvate metabolism EC:3.1.2.1
is: SBO:0000176
reversible: false
modifier: MODEL1310110002#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/4.3.1.17
is described by: ECO:0000000
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_6bcfc195_b27c_4307_91ac_1bf5eaec2b9c
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:2643
initial amount: NaN
name: GCH1
initial concentration: NaN
is: Q8IZH9

metaR FUM
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.2
reversible: true
product: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
name: fumarase
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
fast: false

metaR VALTAm
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
name: valine transaminase, mitochondiral
kinetic law: MODEL1310110002#
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.42
type: Reaction
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
fast: false
is described by: ECO:0000269
product: MODEL1310110002#

metaR r1606
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110002#
type: Reaction

metaM s2l2n2m2mn l
boundary condition: false
is: HMDB01356
notes: FORMULA: C76H123N5O57 CHARGE: -2
type: Species
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)
is: CHEBI:57312
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
has only substance units: false

metaM estrone r
notes: FORMULA: C18H22O2 CHARGE: 0 INCHI: InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1 EHMN_ABBREVIATION: C00468
is: HMDB00145
initial amount: NaN
name: estrone
initial concentration: 1.0
is: CHEBI:17263
is: SBO:0000247
constant: false
type: Species
has only substance units: false
boundary condition: false

metaM HC01410 m
notes: FORMULA: C27H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O17P3S/c1-4-5-6-7-18(36)55-11-10-29-17(35)8-9-30-25(39)22(38)27(2,3)13-48-54(45,46)51-53(43,44)47-12-16-21(50-52(40,41)42)20(37)26(49-16)34-15-33-19-23(28)31-14-32-24(19)34/h6-7,14-16,20-22,26,37-38H,4-5,8-13H2,1-3H3,(H,29,35)(H,30,39)(H,43,44)(H,45,46)(H2,28,31,32)(H2,40,41,42)/b7-6+/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05271
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: CHEBI:28706
initial concentration: 1.0
name: (2E)-Hexenoyl-CoA

metaR GALT
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110002#
product: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.7.12
is: SBO:0000176
name: galactose-1-phosphate uridylyltransferase

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

metaM pro D e
type: Species
is: CHEBI:16313
is: SBO:0000247
constant: false
name: D-proline
is: HMDB03411
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false

metaM 2obut m
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-2-3(5)4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
is: HMDB00005
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:16763
name: 2-oxobutanoate
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR B3GNT313g
type: Reaction
fast: false
is described by: ECO:0000254
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
product: MODEL1310110002#
is: SBO:0000176
reversible: false
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ

metaR RE3272N
type: Reaction
is: SBO:0000176
name: RE3272
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:
reactant: MODEL1310110002#
product: MODEL1310110002#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_749edc10_c385_4e51_9a31_b6d591d0186c
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q5T4Y1
constant: false
is encoded by: hsa:6487
type: Species
name: ST3GAL3
initial concentration: NaN

metaM 5aizc c
is: CHEBI:58564
initial amount: NaN
is: C04751
is: HMDB06273
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C9H11N3O9P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01347 EHMN_ABBREVIATION: C04751
is: SBO:0000247
type: Species
has only substance units: false
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

metaR r0899
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
name: Amino acid transporter ATB0+ Facilitated diffusion
is: SBO:0000185
fast: false

metaM chsterol l
name: cholesterol
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
boundary condition: false
initial concentration: 1.0
is: CHEBI:16113
initial amount: NaN
is: SBO:0000247
is: HMDB00067
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_3cafd28d_eef9_4d2b_8b45_cdc46141da5a
is encoded by: hsa:7296
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: TXNRD1
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_5f4e5e60_88c2_494e_b943_ff94591dfee8
initial amount: NaN
is encoded by: hsa:AI684467
name: _AI684467_1_m
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_56ff9ecc_4dff_459d_b6f1_3c5fe5f05f83
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:LOC727762
name: _LOC727762_1_m
has only substance units: false
is: SBO:0000252

metaR r1551
is described by: ECO:0000000
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110002#
reversible: true
fast: false
kinetic law: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM gln L e
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: SBO:0000247
is: CHEBI:18050
type: Species
is: HMDB00641
constant: false
name: L-glutamine
has only substance units: false
initial amount: NaN

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

metaM ksii core2 pre2 g
is: C00130
boundary condition: false
notes: FORMULA: C39H63N3O28X CHARGE: -1
is: CHEBI:58053
is: HMDB00175
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: keratan sulfate II biosynthesis, precursor 2
type: Species
has only substance units: false
constant: false

metaM msa m
initial concentration: 1.0
name: 3-oxopropanoate
initial amount: NaN
type: Species
constant: false
is: HMDB11111
is: SBO:0000247
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
boundary condition: false
is: CHEBI:33190
has only substance units: false

metaM T antigen g
type: Species
name: T antigen (core 1)
initial amount: NaN
notes: FORMULA: C14H24NO10X CHARGE: 0
is: CHEBI:22783
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false

metaR NADHtru
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is: SBO:0000185
kinetic law: MODEL1310110002#
is described by: ECO:0000000
name: NADH transporter, endoplasmic reticulum
reversible: false
fast: false
product: MODEL1310110002#
reactant: MODEL1310110002#

metaR GALU
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
modifier: MODEL1310110002#
type: Reaction
reversible: true
is described by: ECO:0000134
product: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.9
reactant: MODEL1310110002#
name: UTP-glucose-1-phosphate uridylyltransferase
kinetic law: MODEL1310110002#
is: SBO:0000176

metaR r0497
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
is version of: http://identifiers.org/ec-code/1.2.4.2
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39

http://identifiers.org/biomodels.db/MODEL1310110002#_857387ad_c096_4fb9_80df_174f0278cdd3
type: Species
name: MIA3
initial concentration: NaN
initial amount: NaN
constant: false
is: Q5JRA6
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:375056

http://identifiers.org/biomodels.db/MODEL1310110002#_f84d054f_d769_438f_86a3_dc654e70f289
is encoded by: hsa:10317
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
name: B3GALT5

http://identifiers.org/biomodels.db/MODEL1310110002#_b37b472c_a53b_4706_8a97_36c695b80bba
is: Q8NCL4
initial concentration: NaN
constant: false
boundary condition: true
name: GALNT6
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:11226

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR EX prpp LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
type: Reaction

metaM ksi pre10 g
is: CHEBI:58053
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB00175
name: keratan sulfate I biosynthesis, precursor 10
is: C00130
notes: FORMULA: C129H209N9O98S2X CHARGE: -3
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_8933dbd8_c29a_4964_846b_4192db7d7ce5
has only substance units: false
initial concentration: NaN
name: ST3GAL1
is encoded by: hsa:6482
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252

metaR FAOXC12DCC10DCx
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12DC-->C10DC)x
type: Reaction

metaM acgal l
is: CHEBI:28037
type: Species
is: SBO:0000247
constant: false
is: HMDB00212
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
has only substance units: false
boundary condition: false
name: N-acetyl-D-galactosamine

metaM hdd2coa m
has only substance units: false
constant: false
is: HMDB03945
is: SBO:0000247
name: trans-Hexadec-2-enoyl-CoA
is: C05272
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:61526
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_8b87e6a1_7016_431e_8511_f0bc5e7ada1a
initial concentration: NaN
is encoded by: hsa:D87002
boundary condition: true
type: Species
name: _D87002_1_e
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_369cd2b2_a339_4388_91b8_88f0d42fd92b
has only substance units: false
is encoded by: hsa:55312
name: RFK
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is: B2RDZ2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_74b44d79_049e_4db3_85dc_48501b28df4d
type: Species
name: RPN2
is encoded by: hsa:6185
has only substance units: false
initial amount: NaN
is: P04844
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true

metaM glyc3p m
name: Glycerol 3-phosphate
has only substance units: false
type: Species
constant: false
boundary condition: false
is: C00093
is: CHEBI:57597
is: SBO:0000247
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
initial concentration: 1.0
is: HMDB00126
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_fbeddecf_eac8_4255_aa92_7bb8f1e19563
is: B2R6S5
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:51727
name: CMPK1
type: Species
boundary condition: true

metaM ha e
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16336
name: hyaluronan
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518

metaR PRPPS
is described by: ECO:0000000
modifier: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
name: phosphoribosylpyrophosphate synthetase
reversible: true
is: SBO:0000176
fast: false
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.6.1

metaR r1608
product: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_50fb47fc_6bcf_4a7a_b296_1e18efbc3b5d
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:10873
initial amount: NaN
boundary condition: true
is: Q6TCH8
initial concentration: NaN
name: ME3
has only substance units: false

metaM 5dhf e
constant: false
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
name: pentaglutamyl folate (DHF)
initial concentration: 1.0
is: HMDB06487

metaM gln L c
name: L-glutamine
has only substance units: false
type: Species
is: HMDB00641
constant: false
is: CHEBI:18050
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067

metaR GULNter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: L-gulonate endoplasmic reticular export
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110002#
fast: false
reversible: false
type: Reaction

metaR r1553
kinetic law: MODEL1310110002#
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_2581d483_65d1_4a62_a7e6_4b56126d1bf4
name: _AI971036_1_x
is encoded by: hsa:AI971036
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is: SBO:0000252

metaM galacglcgalgbside hs g
initial concentration: 1.0
initial amount: NaN
name: Gal-GlcNAc-Gal globoside
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
has only substance units: false
constant: false
is: CHEBI:26174

metaM 3ohdcoa m
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57349
has only substance units: false
initial amount: NaN
type: Species
name: 3-oxopalmitoyl-CoA(4-)
notes: FORMULA: C37H60N7O18P3S CHARGE: -4 INCHI: InChI=1S/C37H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h23-24,26,30-32,36,48-49H,4-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/t26-,30-,31-,32+,36-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01398 EHMN_ABBREVIATION: C05259
boundary condition: false
is: HMDB06402

http://identifiers.org/biomodels.db/MODEL1310110002#_7fabf062_054f_468f_961f_704967c98356
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: NDUFS3
initial concentration: NaN
is encoded by: hsa:4722
boundary condition: true
constant: false
is: O75489

http://identifiers.org/biomodels.db/MODEL1310110002#_4d7799f4_2b46_4404_b154_6910d1cbaf55
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
name: UGP2
initial concentration: NaN
is encoded by: hsa:7360
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_84e01ec3_66f0_40c3_98b9_97fb5a94550a
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: SLC17A5
has only substance units: false
is: Q9NRA2
is encoded by: hsa:26503
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_7d09865a_0d10_4439_84ad_166020fee2db
is: P30613
is encoded by: hsa:5313
type: Species
name: PKLR
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaM gal l
is: CHEBI:12936
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
initial concentration: 1.0
name: D-galactose
is: HMDB00143
type: Species
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false

metaR GLYt4
kinetic law: MODEL1310110002#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:SAB irreversible
reactant: MODEL1310110002#
fast: false
modifier: MODEL1310110002#
name: glycine transport via sodium symport
product: MODEL1310110002#
reversible: false
is described by: ECO:0000269

metaM trp L e
boundary condition: false
initial concentration: 1.0
is: CHEBI:16828
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: HMDB00929
is: SBO:0000247
initial amount: NaN
name: L-tryptophan
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_9fde241a_d5cc_4bb1_9c58_181ebf7cf1af
is: SBO:0000252
boundary condition: true
constant: false
type: Species
initial concentration: NaN
name: AACS
initial amount: NaN
is: Q86V21
has only substance units: false
is encoded by: hsa:65985

http://identifiers.org/biomodels.db/MODEL1310110002#_4f884353_fa73_4007_8f96_15ea93f47376
name: SLC26A9
is: SBO:0000252
type: Species
is: Q7LBE3
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:115019
initial concentration: NaN
constant: false

metaM xu5p D c
has only substance units: false
constant: false
is: CHEBI:57737
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
is: HMDB00868
type: Species
name: D-xylulose 5-phosphate(2-)

http://identifiers.org/biomodels.db/MODEL1310110002#_8af0991d_bac2_4390_a40b_c863277aea92
is encoded by: hsa:117247
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is: Q8TF71
name: SLC16A10
has only substance units: false
constant: false

metaM ddcacoa x
type: Species
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
constant: false
has only substance units: false
is: HMDB03571
is: SBO:0000247
is: CHEBI:57375
boundary condition: false
name: Dodecanoyl-CoA (n-C12:0CoA)
initial amount: NaN
initial concentration: 1.0
is: C01832

http://identifiers.org/biomodels.db/MODEL1310110002#_5ba24de0_36ec_41f6_a224_d188017cb40f
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
name: NDUFS1
constant: false
is: P28331
initial concentration: NaN
type: Species
is encoded by: hsa:4719

metaR ARACHDt2
is: SBO:0000185
name: fatty acid transport via diffusion
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_a6e4fa48_4f91_497f_b8a0_57192740c12b
constant: false
initial concentration: NaN
name: _AW277253_1_c
is: SBO:0000252
boundary condition: true
type: Species
is encoded by: hsa:AW277253
has only substance units: false
initial amount: NaN

metaM CE2838 e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: maltononaose
boundary condition: false
notes: FORMULA: C54H92O46 CHARGE: 0 INCHI: InChI=1/C54H92O46/c55-1-10-19(64)20(65)30(75)47(85-10)94-39-12(3-57)87-49(32(77)22(39)67)96-41-14(5-59)89-51(34(79)24(41)69)98-43-16(7-61)91-53(36(81)26(43)71)100-45-18(9-63)92-54(37(82)28(45)73)99-44-17(8-62)90-52(35(80)27(44)72)97-42-15(6-60)88-50(33(78)25(42)70)95-40-13(4-58)86-48(31(76)23(40)68)93-38-11(2-56)84-46(83)29(74)21(38)66/h10-83H,1-9H2/t10-,11-,12-,13-,14-,15-,16-,17-,18-,19+,20+,21-,22-,23-,24-,25-,26-,27-,28-,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46u,47+,48+,49+,50+,51+,52+,53+,54+/m1/s1 EHMN_ABBREVIATION: CE2838
constant: false
is: http://identifiers.org/pubchem.compound/5041
initial amount: NaN
is: C01936
type: Species

metaR r1552
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
product: MODEL1310110002#
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110002#

metaR NDPK4n
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000304
fast: false
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
is: SBO:0000176

metaM 10fthf7glu e
is: CHEBI:57454
constant: false
notes: FORMULA: C50H57N13O25 CHARGE: -8
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
name: 10-formyltetrahydrofolate-[Glu](7)
initial amount: NaN
is: SBO:0000247
is: HMDB00972

http://identifiers.org/biomodels.db/MODEL1310110002#_8277c9ae_c3b4_4a1d_a0cd_da770f78555c
initial concentration: NaN
initial amount: NaN
is: Q59EA4
is encoded by: hsa:5337
is: SBO:0000252
boundary condition: true
name: PLD1
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_2cdea785_bb48_4104_9c24_e9bd89b1baf9
boundary condition: true
constant: false
has only substance units: false
type: Species
is: Q9UEF7
is encoded by: hsa:9365
initial concentration: NaN
is: SBO:0000252
name: KL
initial amount: NaN

metaR CYSTA
product: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.1
name: cysteine transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.3 Confidence Level: 2 AUTHORS: PMID:15189131,PMID:7113743 NOTES:MM
reactant: MODEL1310110002#
type: Reaction
fast: false
kinetic law: MODEL1310110002#
reversible: true

metaR RE0926E
name: RE0926
reversible: true
reactant: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000
modifier: MODEL1310110002#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.1

metaR r2338
product: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110002#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12883891 NOTES:

metaR r1602
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110002#
is: SBO:0000185
reactant: MODEL1310110002#
fast: false
reversible: true
kinetic law: MODEL1310110002#
is described by: ECO:0000000

metaR NAt3 1
product: MODEL1310110002#
is: SBO:0000185
reversible: true
name: sodium proton antiporter (H:NA is 1:1)
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (389015.1) or (6548.1) or (6550.1) or (6549.1) or (6553.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10444453,PMID:12845533,PMID:2536298,PMID:2581505,PMID:7631746,PMID:7759094,PMID:8199403,PMID:8595899,PMID:9933641 NOTES:JLR
reactant: MODEL1310110002#

metaR FAOXC2252053m
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox - c22:5,n-3 -> c20:5, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110002#
reversible: false
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110002#
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_c2efc250_0ebe_411f_b159_91a4fde15e56
constant: false
is: SBO:0000252
is encoded by: hsa:84129
boundary condition: true
initial amount: NaN
name: ACAD11
type: Species
is: Q709F0
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_b856cbe2_7310_481b_871f_ea1360e87e8f
is: SBO:0000252
type: Species
is: Q8N0W3
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:197258
name: FUK
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_2668194f_d502_4276_85c3_43d866df4343
name: _T83654_1_m
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:T83654
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR FUMTSULtm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is described by: ECO:0000269
reversible: true
type: Reaction
name: Fumarate:thiosulfate antiport, mitochondrial
is: SBO:0000185
product: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#

metaM CE2839 e
is: C01936
type: Species
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
is: SBO:0000247
name: maltodecaose
boundary condition: false
constant: false
has only substance units: false
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
initial amount: NaN

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_b617c82a_2cf6_4995_9eeb_63dd293534f0
initial concentration: NaN
type: Species
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:5291
is encoded by: hsa:5295
name: PIK3CB:PIK3R1
constant: false
has only substance units: false
boundary condition: true
has part: B4DER4
has part: B3KT19

metaR r0527
reactant: MODEL1310110002#
name: Nicotinamide-D-ribonucleotide amidohydrolase Nicotinate and nicotinamide metabolism EC:3.5.1.42
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD metabolism EC Number: 3.5.1.42 Confidence Level: 0 AUTHORS: PMID:7021549 NOTES:
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
fast: false
is described by: ECO:0000000

metaM sphs1p r
type: Species
name: sphingosine 1-phosphate(1-)
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB00277
constant: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_3bbe1517_e838_4d3a_aec1_bb3f60a96b0c
constant: false
initial concentration: NaN
is: A8K5Z0
name: B4GALT3
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8703
type: Species
boundary condition: true

metaR RE0691C
kinetic law: MODEL1310110002#
name: RE0691
is described by: ECO:0000000
reversible: true
fast: false
is: SBO:0000176
reactant: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110002#

metaM taur e
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:3544
is: HMDB00251
constant: false
name: Taurine
notes: FORMULA: C2H7NO3S CHARGE: 0
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: C00245

http://identifiers.org/biomodels.db/MODEL1310110002#_0e9a3dc3_34a9_4ee1_9021_93ffecf9c82d
initial concentration: NaN
constant: false
is encoded by: hsa:956
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ENTPD3
has only substance units: false
type: Species
is: O75355

http://identifiers.org/biomodels.db/MODEL1310110002#_ba54a2f1_6b82_4bdc_a8b0_19113821a4a6
is: SBO:0000252
is encoded by: hsa:4719
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: NDUFS1
is: P28331
type: Species
boundary condition: true

metaR MM5ag
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
reversible: false
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
modifier: MODEL1310110002#
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
is version of: http://identifiers.org/ec-code/3.2.1.113

metaR NMNATr
type: Reaction
reversible: true
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/2.7.7.1
is described by: ECO:0000269
name: nicotinamide-nucleotide adenylyltransferase

metaM trp L c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
is: HMDB00929
boundary condition: false
type: Species
is: CHEBI:16828
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
initial amount: NaN
name: L-tryptophan

metaM ksii core4 pre4 g
initial amount: NaN
type: Species
is: CHEBI:58053
boundary condition: false
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 4
initial concentration: 1.0
is: HMDB00175
is: SBO:0000247
constant: false
notes: FORMULA: C61H99N5O43X CHARGE: -1
is: C00130

metaR r1603
kinetic law: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR r1554
reactant: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reversible: true
product: MODEL1310110002#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
kinetic law: MODEL1310110002#

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaR r0450
modifier: MODEL1310110002#
is: SBO:0000176
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/4.2.1.3
reversible: true
fast: false
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
kinetic law: MODEL1310110002#

metaR UGCG
type: Reaction
reversible: false
name: Ceramide glucosyltransferase
notes: GENE_ASSOCIATION: (7357.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.1.80 Confidence Level: 4 AUTHORS: PMID:8643456 NOTES:NJ
fast: false
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.80
product: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_9edfdae8_6969_4323_9b60_83baf2849dea
is: SBO:0000252
is encoded by: hsa:1346
constant: false
has only substance units: false
is: P24310
initial amount: NaN
name: COX7A1
boundary condition: true
type: Species
initial concentration: NaN

metaR r0679
reactant: MODEL1310110002#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110002#_ecb0d179_d6e9_4680_bf6f_00a052b1935c
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:1374
type: Species
is: Q8WZ48
constant: false
is: SBO:0000252
name: CPT1A

metaM gthox c
initial concentration: 1.0
is: SBO:0000247
name: Oxidized glutathione
is: HMDB03337
boundary condition: false
is: C00127
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
constant: false
is: CHEBI:58297
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_6510079c_a96a_47ae_a717_76022334cd2e
name: _BE966236_1_c
constant: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:BE966236
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_ff745a97_ea6d_47ac_ba78_c2b291149a76
initial concentration: NaN
is encoded by: hsa:57419
name: SLC24A3
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: Q9HC58
has only substance units: false

metaM rnam c
boundary condition: false
name: N-Ribosylnicotinamide
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C11H15N2O5 CHARGE: 1 INCHI: InChI=1S/C11H14N2O5/c12-10(17)6-2-1-3-13(4-6)11-9(16)8(15)7(5-14)18-11/h1-4,7-9,11,14-16H,5H2,(H-,12,17)/p+1/t7-,8-,9-,11-/m1/s1 EHMN_ABBREVIATION: C03150
is: CHEBI:15927
is: HMDB00855
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_b8a955a7_2eba_4aec_b7a9_f22bf34ff61e
initial concentration: NaN
is: P48067
initial amount: NaN
has only substance units: false
boundary condition: true
name: SLC6A9
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:6536

metaM pro D c
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
boundary condition: false
has only substance units: false
is: CHEBI:16313
constant: false
is: HMDB03411
initial concentration: 1.0
is: SBO:0000247
name: D-proline
initial amount: NaN
type: Species

metaM h x
is: CHEBI:24636
constant: false
is: http://identifiers.org/pubchem.compound/3380
name: proton
is: SBO:0000247
initial concentration: 1.0
is: C00080
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_5105ac84_53fe_4655_b968_0e76091cbb97
is: Q7L266
boundary condition: true
constant: false
type: Species
name: ASRGL1
is encoded by: hsa:80150
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN

metaR CH25H
reversible: false
is version of: http://identifiers.org/ec-code/1.14.99.38
reactant: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000269
name: cholesterol 25-hydroxylase
type: Reaction
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (9023.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110002#
fast: false

metaR r1604
fast: false
is: SBO:0000185
reversible: true
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM malt e
is: CHEBI:17306
name: Maltose
is: SBO:0000247
constant: false
type: Species
has only substance units: false
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00194 EHMN_ABBREVIATION: C00208
initial amount: NaN
boundary condition: false
is: C00208
is: HMDB00163
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_3e5f1d33_3081_498f_8194_a56edffa94db
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:AI345944
name: _AI345944_1_m

http://identifiers.org/biomodels.db/MODEL1310110002#_86ee8cf6_cd7f_43cc_9d0e_8b69bae570d4
initial amount: NaN
name: SLC16A8
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:23539
is: O95907
has only substance units: false
boundary condition: true
constant: false
type: Species

metaM acgal g
name: N-acetyl-D-galactosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
type: Species
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: CHEBI:28037
initial concentration: 1.0
is: SBO:0000247
is: HMDB00212

metaR GCNTg
reactant: MODEL1310110002#
fast: false
type: Reaction
name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
is described by: ECO:0000269
is: SBO:0000176
reversible: false
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.150
product: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (2651.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.150 Confidence Level: 4 AUTHORS: PMID:15161861,PMID:8449405 NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110002#_dad06b28_fcfd_41bd_b0a1_b5ca226cd01f
is: SBO:0000252
boundary condition: true
is encoded by: hsa:AI971036
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
name: _AI971036_1_m
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_78ac89e3_4a12_4a50_8881_1306b7c62054
initial concentration: NaN
is encoded by: hsa:29922
has only substance units: false
boundary condition: true
initial amount: NaN
name: NME7
type: Species
constant: false
is: SBO:0000252

metaR CERT2gt
kinetic law: MODEL1310110002#
reversible: true
fast: false
type: Reaction
name: ceramide transport protein
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.11.1

metaM chol e
initial concentration: 1.0
name: Choline
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
constant: false
is: C00114
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
is: HMDB00097
has only substance units: false
is: CHEBI:15354

metaR RPEc
name: ribulose 5-phosphate 3-epimerase
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2

metaM acngalgbside hs g
is: HMDB03406
is: SBO:0000247
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C61H105N3O35FULLRCO CHARGE: -1
constant: false
type: Species
is: CHEBI:16523
name: sialyl galactosylgloboside
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_8204c625_5144_4634_9bbd_37ec58ad570b
has only substance units: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q13057
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:80347
name: COASY

metaR DUDPtn
kinetic law: MODEL1310110002#
reversible: true
product: MODEL1310110002#
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
name: dUDP nuclear transport
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT

metaM pyr e
type: Species
is: HMDB00243
is: CHEBI:15361
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
name: pyruvate

metaR THRGLYexR
is: SBO:0000185
reversible: true
fast: false
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
name: L-threonine/glycine reversible exchange
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
is described by: ECO:0000304

metaM dgtp e
initial concentration: 1.0
initial amount: NaN
boundary condition: false
name: dGTP
type: Species
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: SBO:0000247
constant: false
is: HMDB01440
is: CHEBI:16497

http://identifiers.org/biomodels.db/MODEL1310110002#_7d5adc3f_77a8_4d5c_b437_e733e1b1f070
is: SBO:0000252
name: MOGS
has only substance units: false
initial amount: NaN
is: F5H6D0
type: Species
initial concentration: NaN
is encoded by: hsa:7841
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_d414654f_6c3f_4885_ba54_0c9046c3e270
type: Species
has only substance units: false
constant: false
name: ALDH1A2
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8854
is: B4DZR2
is: SBO:0000252

metaR AMPtp
is: SBO:0000185
type: Reaction
name: AMP transporter, peroxisome
is described by: ECO:0000000
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ

http://identifiers.org/biomodels.db/MODEL1310110002#_9608c630_9a12_4bf9_8f22_1f10896f667d
initial amount: NaN
initial concentration: NaN
name: SLC17A1
type: Species
is: SBO:0000252
boundary condition: true
is: Q14916
constant: false
is encoded by: hsa:6568
has only substance units: false

metaM galacglcgalgbside hs c
is: HMDB00061
initial concentration: 1.0
is: SBO:0000247
name: Gal-GlcNAc-Gal globoside
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:58343
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_780f2ed7_76e5_466c_861a_19153d91b682
has only substance units: false
name: DLD:DLST:OGDH:PDHX
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true
has part: B4E3E9
is: SBO:0000297
is encoded by: hsa:4967

metaM ahcys m
has only substance units: false
is: CHEBI:16680
initial concentration: 1.0
is: HMDB00939
initial amount: NaN
is: SBO:0000247
name: S-Adenosyl-L-homocysteine
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
constant: false
boundary condition: false
type: Species
is: C00021

metaM thcrm hs g
initial amount: NaN
has only substance units: false
is: CHEBI:24636
boundary condition: false
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
type: Species
name: trihexosyl ceramide
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_b98b9fd9_af5d_465b_9ddd_40f3a36a4520
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: _AA614647_1_c
initial concentration: NaN
is encoded by: hsa:AA614647
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_517425fa_c55a_4beb_b517_e9c8e3c9c0c8
is: P18283
is encoded by: hsa:2877
initial amount: NaN
type: Species
boundary condition: true
constant: false
has only substance units: false
name: GPX2
initial concentration: NaN
is: SBO:0000252

metaR LTA4H
type: Reaction
is version of: http://identifiers.org/ec-code/3.3.2.6
reactant: MODEL1310110002#
reversible: false
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
kinetic law: MODEL1310110002#
name: Leukotriene A-4 hydrolase
product: MODEL1310110002#
is: SBO:0000176
fast: false
is described by: ECO:0000134
modifier: MODEL1310110002#

metaM ha pre1 e
name: hyaluronan biosynthesis, precursor 1
boundary condition: false
notes: FORMULA: C14H20NO11 CHARGE: -1 INCHI: InChI=1S/C14H21NO11/c1-4(17)15-8-11(10(20)7(3-16)24-13(8)23)26-14-9(19)5(18)2-6(25-14)12(21)22/h2,5,7-11,13-14,16,18-20,23H,3H2,1H3,(H,15,17)(H,21,22)/t5-,7+,8+,9+,10+,11+,13+,14-/m0/s1
initial amount: NaN
is: CHEBI:16126
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false

metaM gdpddman c
name: GDP-4-dehydro-6-deoxy-alpha-D-mannose(2-)
has only substance units: false
type: Species
notes: FORMULA: C16H21N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H23N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,8-11,14-15,23-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00728 EHMN_ABBREVIATION: C01222
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57964
is: SBO:0000247
is: HMDB01346
boundary condition: false
constant: false

metaR FAOXC61C4m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6:1-->C4:0)m
type: Reaction

metaM oagd3 hs g
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
is: CHEBI:17315
is: SBO:0000247
is: C00329
constant: false
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB01514
boundary condition: false
name: 9-O-Acetylated GD3
initial amount: NaN

metaR GLYCtm
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV
reversible: true
is: SBO:0000185
name: glycerol transport
is described by: ECO:0000000
reactant: MODEL1310110002#
fast: false
type: Reaction
product: MODEL1310110002#

metaR R group phosphotase 2
is described by: ECO:0000000
product: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
reversible: false
name: R group phosphotase 2
kinetic law: MODEL1310110002#
fast: false
type: Reaction
reactant: MODEL1310110002#

metaM dudp n
is: HMDB01000
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
type: Species
constant: false
initial amount: NaN
is: CHEBI:60471
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: dUDP(3-)

metaM asp L c
is: CHEBI:29991
initial amount: NaN
has only substance units: false
constant: false
is: HMDB00191
name: L-aspartate(1-)
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
boundary condition: false
is: SBO:0000247
type: Species

metaR RE3270C
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
name: RE3270
fast: false

metaR COAtr
reactant: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
name: COA transporter, endoplasmic reticulum

metaR THYMt
is: SBO:0000185
kinetic law: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
is described by: ECO:0000269
name: thymine reversible transport via facilated diffusion
modifier: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
fast: false

metaR r0829
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110002#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.1.1.37
reversible: true
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_311c663e_6d3a_4d7f_8030_eb3c5f789c2c
is encoded by: hsa:4832
name: NME3
is: SBO:0000252
has only substance units: false
boundary condition: true
is: Q13232
constant: false
type: Species
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_af878704_0bf7_4bfc_9350_50d103852cce
initial amount: NaN
is: SBO:0000252
name: _D29675_1_c
initial concentration: NaN
is encoded by: hsa:D29675
type: Species
boundary condition: true
constant: false
has only substance units: false

metaM HC00718 c
is: CHEBI:57781
name: N-methylethanolaminium phosphate(1-)
boundary condition: false
notes: FORMULA: C3H9NO4P CHARGE: -1 INCHI: InChI=1S/C3H10NO4P/c1-4-2-3-8-9(5,6)7/h4H,2-3H2,1H3,(H2,5,6,7)/p-1
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR GALK
is version of: http://identifiers.org/ec-code/2.7.1.6
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
product: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.157
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#
name: galactokinase
fast: false
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH

metaR r1443
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:17603022,PMID:6240978,PMID:7876265 NOTES:
fast: false
name: EC:1.3.3.6
reactant: MODEL1310110002#
reversible: false
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#

metaM pglyc hs c
is: HMDB00156
is: CHEBI:15589
is: SBO:0000247
initial concentration: 1.0
constant: false
name: pglyc_hs[c]
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110002#_e324e23b_3e55_440a_8225_b447cbbdff5a
initial concentration: NaN
constant: false
boundary condition: true
is: Q02218
type: Species
is: SBO:0000252
is encoded by: hsa:4967
has only substance units: false
name: OGDH
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_20ad3e42_28de_4120_9d20_90bbbb8adacb
constant: false
is: A8K7J7
is encoded by: hsa:3098
has only substance units: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
name: HK1

metaR r1446
name: EC:1.3.3.6
fast: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:17603022,PMID:1774065,PMID:3597357,PMID:6240978,PMID:7876265 NOTES:
reactant: MODEL1310110002#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110002#_fcd719d1_0b12_44fc_83c0_c7eb4fa3bfd5
boundary condition: true
type: Species
is encoded by: hsa:79646
initial amount: NaN
is: SBO:0000252
constant: false
name: PANK3
is: Q9H999
has only substance units: false
initial concentration: NaN

metaR PROt4 2 r
kinetic law: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#
is described by: ECO:0000006
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
name: Proline transport (sodium symport) (2:1)
type: Reaction
fast: false
reactant: MODEL1310110002#
reversible: true
modifier: MODEL1310110002#

metaM gln L m
type: Species
is: HMDB00641
constant: false
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:18050
initial amount: NaN
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
initial concentration: 1.0
name: L-glutamine

metaM HC02202 e
is: CHEBI:57398
type: Species
initial concentration: 1.0
constant: false
name: prostaglandin A1(1-)
is: SBO:0000247
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
initial amount: NaN
boundary condition: false

metaR r0523
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 6.3.3.2 Confidence Level: 0 AUTHORS: PMID:12207015,PMID:12764149,PMID:8522195 NOTES:
reversible: false
modifier: MODEL1310110002#
type: Reaction
name: 5-Formyltetrahydrofolate cyclo-ligase (ADP-forming) One carbon pool by folate EC:6.3.3.2
fast: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.17.4.1
product: MODEL1310110002#

metaM dudp m
constant: false
initial amount: NaN
boundary condition: false
is: HMDB01000
is: SBO:0000247
name: dUDP(3-)
is: CHEBI:60471
notes: FORMULA: C9H11N2O11P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O11P2/c12-5-3-8(11-2-1-7(13)10-9(11)14)21-6(5)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,10,13,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00768 EHMN_ABBREVIATION: C01346
initial concentration: 1.0
has only substance units: false
type: Species

metaR R group phosphotase 1
product: MODEL1310110002#
reversible: false
kinetic law: MODEL1310110002#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000176
reactant: MODEL1310110002#
type: Reaction
name: R group phosphotase 1

http://identifiers.org/biomodels.db/MODEL1310110002#_53f12ee3_6e6f_494f_98b7_a804b66562a8
initial amount: NaN
initial concentration: NaN
is: P22303
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:43
name: ACHE
type: Species

metaR SIAASE3ly
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.4.16.5
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reversible: false
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.23
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_2f2156fa_4625_4fe2_bbbf_72a1990fea83
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
name: _AI620219_1_m
has only substance units: false
initial amount: NaN
is encoded by: hsa:AI620219
constant: false

metaM hedepecoa m
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: 2,4,7,10,13-hexadecapentenoylcoa
constant: false
initial amount: NaN
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
is: HMDB02288
is: SBO:0000247
type: Species

metaR DHORD9
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110002#
reversible: false
is: SBO:0000185
name: dihydoorotic acid dehydrogenase (quinone10)
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
is version of: http://identifiers.org/ec-code/1.3.5.2

metaM chol c
is: CHEBI:15354
initial concentration: 1.0
name: Choline
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H14NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00112 EHMN_ABBREVIATION: C00114
has only substance units: false
constant: false
is: C00114
is: HMDB00097

metaM galacglcgalgbside hs e
is: SBO:0000247
is: CHEBI:0
is: HMDB00143
notes: FORMULA: C64H112N3O37FULLRCO CHARGE: 0
type: Species
name: Gal-GlcNAc-Gal globoside
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: C00124

metaR r0340
modifier: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110002#
reversible: false
type: Reaction
is described by: ECO:0000000
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
is version of: http://identifiers.org/ec-code/1.3.1.38
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:

metaR DOLPMT U
reactant: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (54344.2 and 8818.1 and 8813.1) or (8818.2 and 54344.1 and 8813.1) or (8818.1 and 54344.1 and 8813.1) or (54344.2 and 8818.2 and 8813.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.83 Confidence Level: 0 AUTHORS: PMID:11420690 NOTES:NCD
product: MODEL1310110002#
reversible: false
name: Dolichyl-phosphate D-mannosyltransferase (uterus)
kinetic law: MODEL1310110002#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.83

metaM 2hexdtricoa m
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial amount: NaN
name: 2,7,10-hexadecatrienoylcoa
is: HMDB02288
constant: false

metaR r1600
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
product: MODEL1310110002#
reversible: true
is described by: ECO:0000000
type: Reaction

metaM oagd3 hs e
has only substance units: false
constant: false
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
name: 9-O-Acetylated GD3
is: CHEBI:18421
initial concentration: 1.0
is: HMDB02168

metaR ILETA
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110002#
name: isoleucine transaminase
reversible: true
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
is: SBO:0000176
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
is described by: ECO:0000269

metaR LNLCCRNt
is described by: ECO:0000269
name: transport into the mitochondria (carnitine)
reversible: false
type: Reaction
modifier: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR 3HCO3 NAt
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
type: Reaction
kinetic law: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
is: SBO:0000185
name: 3HCO3_NAt
is described by: ECO:0000134
reversible: true

metaM cs e deg7 l
notes: FORMULA: C23H35O27S2 CHARGE: -3
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
is: CHEBI:15936
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_cc7ddc27_7a9f_4ad8_b385_f4107c81649a
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:123041
initial amount: NaN
name: SLC24A4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_6e49e79d_1aca_4b17_8f43_b67a3be7060f
boundary condition: true
is: P54868
type: Species
is: SBO:0000252
is encoded by: hsa:3158
initial amount: NaN
initial concentration: NaN
constant: false
name: HMGCS2
has only substance units: false

metaR r0892
type: Reaction
name: Facilitated diffusion
is version of: http://identifiers.org/ec-code/3.1.2.27
fast: false
product: MODEL1310110002#
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110002#
is: SBO:0000185
reversible: true

metaM 2obut c
is: HMDB00005
name: 2-Oxobutanoate
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:16763
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00108 EHMN_ABBREVIATION: C00109
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: C00109

http://identifiers.org/biomodels.db/MODEL1310110002#_946c6fb8_a8a1_4b51_ae86_f7f2fe75b225
type: Species
is: Q06830
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:5052
name: PRDX1
has only substance units: false

metaR DCK1n
fast: false
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reactant: MODEL1310110002#
type: Reaction
name: Deoxycytidine kinase, nuclear (ATP)
is version of: http://identifiers.org/ec-code/2.7.1.74
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_a4f31037_2a66_4e3c_ada0_3e6220b61392
type: Species
initial concentration: NaN
is encoded by: hsa:549
is: Q13825
name: AUH
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN

metaR Coqe
product: MODEL1310110002#
type: Reaction
fast: false
name: Transport of q10
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
is described by: ECO:0000134
reversible: true
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_d1ddd0a5_8898_4496_8979_b20e767bf244
initial concentration: NaN
name: PIP5K1A
has only substance units: false
is encoded by: hsa:8394
initial amount: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is: Q99755

metaR r0522
is: SBO:0000176
fast: false
kinetic law: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
name: S-Aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) One carbon pool by folate EC:2.1.2.10
product: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 2.1.2.10 Confidence Level: 0 AUTHORS: PMID:7916605 NOTES:
reversible: false

metaM asp L e
boundary condition: false
type: Species
name: L-aspartate(1-)
initial concentration: 1.0
constant: false
is: HMDB00191
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00055
is: CHEBI:29991
initial amount: NaN
has only substance units: false
is: SBO:0000247

metaR ASPte
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. no such transporter could be found so diffusion reaction is assumed. NOTES:
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110002#
is: SBO:0000185
reversible: true
name: diffusion of aspartate into blood
type: Reaction
reactant: MODEL1310110002#

metaM fgam c
is: SBO:0000247
is: HMDB01308
constant: false
has only substance units: false
is: C04376
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
is: CHEBI:58426
type: Species
initial concentration: 1.0
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide

http://identifiers.org/biomodels.db/MODEL1310110002#_5d6dd724_095d_4fb9_a96f_c14b1538df4a
is: Q53HE2
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
boundary condition: true
name: TPI1
has only substance units: false
is encoded by: hsa:7167
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_70c1710c_0c31_499f_9861_889d32037d50
is: P56556
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
type: Species
name: NDUFA6
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4700

http://identifiers.org/biomodels.db/MODEL1310110002#_c61e9496_e3fc_4f08_a30e_7743755e8428
type: Species
is: P12074
boundary condition: true
is encoded by: hsa:1337
initial amount: NaN
name: COX6A1
is: SBO:0000252
has only substance units: false
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_96c0a1f5_49cb_445d_9a7e_b3a6d4f411f0
is: Q9H845
constant: false
has only substance units: false
boundary condition: true
name: ACAD9
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:28976

http://identifiers.org/biomodels.db/MODEL1310110002#_3be93fa7_77f9_4357_9e91_fb7a5bd2bd55
is: O75715
initial concentration: NaN
boundary condition: true
is encoded by: hsa:2880
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
constant: false
name: GPX5

http://identifiers.org/biomodels.db/MODEL1310110002#_605aa562_8f8d_4922_ba63_e58ae231390f
initial concentration: NaN
name: GUK1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:2987
has only substance units: false
type: Species
constant: false
is: Q16774
boundary condition: true

metaM acgal c
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB00212
is: CHEBI:28037
name: N-acetyl-D-galactosamine
initial amount: NaN

metaM 13 cis retn r
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
initial amount: NaN
constant: false
is: SBO:0000247
name: 13-cis-retinoate
type: Species
is: http://identifiers.org/pubchem.compound/7847414
is: D00348
is: HMDB06219
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_d6bc9ab5_6130_4a88_a2ee_e8e90077a13e
type: Species
constant: false
is: P15531
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: NME1
is encoded by: hsa:4830
is: SBO:0000252

metaR TRPt
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
kinetic law: MODEL1310110002#
is described by: ECO:0000269
name: L-tryptophan transport
modifier: MODEL1310110002#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_8e9d52ac_1eed_4cf8_ae6a_bb50c408561d
constant: false
name: RDH5
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q92781
boundary condition: true
has only substance units: false
is encoded by: hsa:5959

metaM cyan e
has only substance units: false
name: hydrogen cyanide
initial amount: NaN
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
constant: false
is: CHEBI:18407
type: Species
initial concentration: 1.0
is: HMDB02084
is: SBO:0000247
boundary condition: false

metaR RE2972M
product: MODEL1310110002#
name: RE2972
is: SBO:0000176
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.1.67
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5297.1) or (5298.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.67 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:7961848,PMID:9211928 NOTES:
reversible: true

metaM m8mpdol U r
boundary condition: false
is: SBO:0000247
is: CHEBI:59093
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
initial concentration: 1.0
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
has only substance units: false
type: Species
constant: false

metaR EX bilglcur LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for blirubin mono-glucuronide
type: Reaction

metaR HPYRDC
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 4.1.1.40 Confidence Level: 2 AUTHORS: PMID:3778681 NOTES:NCD
reactant: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110002#
is: SBO:0000176
reversible: false
name: hydroxypyruvate decarboxylase
product: MODEL1310110002#

metaR ALASm
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.29
is version of: http://identifiers.org/ec-code/2.3.1.37
is described by: ECO:0000254
fast: false
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#
name: 5-aminolevulinate synthase
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (212.1) or (23464.1) or (211.2) or (211.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.37 Confidence Level: 2 AUTHORS: PMID:2263504 NOTES:NCD

metaM HC02202 c
is: SBO:0000247
has only substance units: false
is: CHEBI:57398
type: Species
constant: false
boundary condition: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
name: prostaglandin A1(1-)
initial concentration: 1.0
initial amount: NaN

metaR r1989
reversible: false
product: MODEL1310110002#
fast: false
modifier: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110002#
name: Y+LAT2 Utilized transport
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110002#

metaR HEXDICOAACBPx
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of hexadecanedioyl coa
type: Reaction

metaR PI4P3K
is version of: http://identifiers.org/ec-code/2.7.1.154
reversible: false
type: Reaction
modifier: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
name: phosphatidylinositol 4-phosphate 3-kinase
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.11.1
reactant: MODEL1310110002#
is: SBO:0000176

metaM chsterol r
type: Species
name: cholesterol
is: CHEBI:16113
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB00067
is: SBO:0000247
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_0d99510d_0595_4886_a4d9_7cc29126dd43
has only substance units: false
is: SBO:0000252
name: ST8SIA1
type: Species
is: Q92185
constant: false
is encoded by: hsa:6489
initial concentration: NaN
boundary condition: true
initial amount: NaN

metaR r0170
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:
kinetic law: MODEL1310110002#
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
reversible: true
is: SBO:0000176
reactant: MODEL1310110002#
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.1.40
type: Reaction
modifier: MODEL1310110002#
fast: false
is described by: ECO:0000000

metaR r2331
type: Reaction
is described by: ECO:0000000
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
reactant: MODEL1310110002#
fast: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_1b0dff1f_9415_4dda_814c_655518e8fbc4
is encoded by: hsa:4842
type: Species
name: NOS1
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
is: B4DG68
boundary condition: true
is: SBO:0000252

metaR DNDPt13m
product: MODEL1310110002#
reactant: MODEL1310110002#
name: dADP transport via ATP antiport
fast: false
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
is: SBO:0000185
is described by: ECO:0000269
reversible: false

metaM oagd3 hs c
is: CHEBI:17315
is: SBO:0000247
notes: FORMULA: C54H90N3O29FULLRCO CHARGE: -2
name: 9-O-Acetylated GD3
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01514
type: Species
is: C00329
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_4e3ec558_15b4_4e3c_99d9_4f530b471649
has only substance units: false
constant: false
is: SBO:0000252
name: B3GALNT1
is: Q49AT3
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:8706
boundary condition: true

metaR LTD4DP
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:11160764,PMID:3001504 NOTES:Converts leukotriene D4 (LTD4) to leukotriene E4 (LTE4). unknown compartmentalization, cytosolic by default NJ
product: MODEL1310110002#
type: Reaction
name: Leukotriene D4 dipeptidase
fast: false
is: SBO:0000176
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_3319e1e9_ec3b_4164_9019_e5ef1e78bf96
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5331
name: PLCB3
is: SBO:0000252
constant: false
is: G5E960
has only substance units: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_f4cd9e23_6323_44ff_a2ce_43a22c758a09
is encoded by: hsa:79966
name: SCD5
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: Q86SK9

metaR r2471
reactant: MODEL1310110002#
fast: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.18.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12748860 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reversible: false

metaM nicrnt c
is: SBO:0000247
boundary condition: false
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
name: Nicotinate D-ribonucleotide
type: Species
initial concentration: 1.0
is: HMDB01132
initial amount: NaN
is: C01185
has only substance units: false
is: CHEBI:57502
constant: false

metaM 3hmp m
boundary condition: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
is: HMDB00023
initial concentration: 1.0
is: CHEBI:11805
type: Species
constant: false
name: 3-hydroxy-2-methylpropanoate
is: SBO:0000247
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_d342b49c_c226_4680_8d5e_4af9eef6c396
is encoded by: hsa:6389
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P31040
name: SDHA
constant: false
type: Species
boundary condition: true

metaM 3odcoa m
initial concentration: 1.0
is: SBO:0000247
is: HMDB03939
type: Species
initial amount: NaN
notes: FORMULA: C31H48N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H52N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-18,20,24-26,30,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t20-,24-,25-,26+,30-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01404 EHMN_ABBREVIATION: C05265
name: 3-Oxodecanoyl-CoA
is: CHEBI:28528
has only substance units: false
constant: false
boundary condition: false

metaM gal c
is: C00124
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00143
is: CHEBI:0
name: D-Galactose
constant: false
is: SBO:0000247

metaM udpgal g
initial amount: NaN
is: CHEBI:58439
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
is: SBO:0000247
has only substance units: false
is: HMDB00302
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
name: UDP-D-galactose(2-)

metaR PAIL HStn
reactant: MODEL1310110002#
is: SBO:0000185
name: phosphatidylinositol nuclear transport (diffusion)
is described by: ECO:0000000
fast: false
product: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaM 10fthf e
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00972
type: Species
boundary condition: false
constant: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
name: 10-formyltetrahydrofolate(2-)

metaR r2330
is: SBO:0000185
reactant: MODEL1310110002#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#

metaR GLCAASE5ly
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110002#
name: beta-glucuronidase, lysosomal
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
fast: false
product: MODEL1310110002#
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31

http://identifiers.org/biomodels.db/MODEL1310110002#_5d8c4ef6_3b9a_4188_acbc_69b625de0c17
type: Species
initial amount: NaN
constant: false
is encoded by: hsa:AI620219
name: _AI620219_1_e
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM hdd2coa c
constant: false
initial amount: NaN
is: CHEBI:61526
is: C05272
is: HMDB03945
is: SBO:0000247
notes: FORMULA: C37H60N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01411 EHMN_ABBREVIATION: C05272
boundary condition: false
has only substance units: false
initial concentration: 1.0
type: Species
name: trans-Hexadec-2-enoyl-CoA

metaR EX 10fthf5glu LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](5) exchange
type: Reaction

metaM galgluside hs g
is: HMDB00295
is: C00015
initial amount: NaN
is: CHEBI:58223
name: galactosyl glucosyl ceramide
boundary condition: false
type: Species
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_bb412fec_4a9f_4212_86e7_71666dac81a3
name: ST3GAL3
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
is encoded by: hsa:6487
constant: false

metaM ahcys r
is: CHEBI:16680
constant: false
is: SBO:0000247
notes: FORMULA: C14H20N6O5S CHARGE: 0 INCHI: InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
name: S-adenosyl-L-homocysteine
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00939

metaR THBPT4ACAMDASE
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395
is: SBO:0000176
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
reversible: false
fast: false
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/4.2.1.96
reactant: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000269
type: Reaction

metaR ACNAMlt
name: N-acetylneuraminate transport into lysososme
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110002#_b9c41f6e_c3ba_4081_acae_9c9013ea2158
is: O43708
constant: false
initial amount: NaN
type: Species
name: GSTZ1
has only substance units: false
is encoded by: hsa:2954
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR ACGALK2
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
name: N-acetylgalactosamine kinase (ITP)
product: MODEL1310110002#
is: SBO:0000176
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
is described by: ECO:0000000

metaM dgtp c
is: CHEBI:16497
name: dGTP
initial amount: NaN
has only substance units: false
is: C00286
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB01440
constant: false
boundary condition: false

metaR DGCHOLte
kinetic law: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
name: bile acid intracellular transport
is: SBO:0000185
reversible: true
reactant: MODEL1310110002#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ

metaR FAOXC183C163Gm
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaM pyr c
is: CHEBI:15361
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00243
type: Species
notes: FORMULA: C3H3O3 CHARGE: -1
has only substance units: false
is: C00022
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3324
name: pyruvate

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_fucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
is: CHEBI:16094
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
is: HMDB00257
boundary condition: false
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_feb68fbd_d038_437e_9521_54b2e062ad0c
is encoded by: hsa:4698
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q16718
constant: false
initial amount: NaN
boundary condition: true
name: NDUFA5

metaR r2333
reactant: MODEL1310110002#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000

metaM dtdp n
boundary condition: false
constant: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: HMDB01274
initial amount: NaN
is: CHEBI:58369
has only substance units: false
type: Species
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: SBO:0000247
initial concentration: 1.0

metaM methf m
type: Species
initial concentration: 1.0
is: CHEBI:57455
notes: FORMULA: C20H20N7O6 CHARGE: -1 INCHI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p-1/t12-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00360 EHMN_ABBREVIATION: C00445
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
name: (6R)-5,10-methenyltetrahydrofolate
is: HMDB01354

metaR r0494
reactant: MODEL1310110002#
reversible: true
fast: false
is: SBO:0000176
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110002#
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_e568c5c4_70d4_405b_9d78_03d7ff16669e
is: Q549M5
initial amount: NaN
constant: false
name: NDUFC2
initial concentration: NaN
is encoded by: hsa:4718
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_0d4f8dbd_f68c_4e0e_93cf_c7ada46b6bab
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:55350
name: VNN3

http://identifiers.org/biomodels.db/MODEL1310110002#_a79bdab1_bd09_43e2_a9c9_7ec0a9caf5a4
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:224
has only substance units: false
name: ALDH3A2
initial amount: NaN
boundary condition: true
is: P51648

http://identifiers.org/biomodels.db/MODEL1310110002#_c900f294_fb6f_47e3_b347_bd85ae9c6c58
has only substance units: false
name: NDUFS6
is encoded by: hsa:4726
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: Q6IBC4

metaR UDPtl
kinetic law: MODEL1310110002#
name: udp intracellular transport
reversible: true
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
fast: false
product: MODEL1310110002#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_c35a9f9d_cd63_4437_a512_465cb17776e0
is encoded by: hsa:160851
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
constant: false
is: Q86XP1
initial concentration: NaN
is: SBO:0000252
name: DGKH

metaR r0345
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110002#
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
reversible: true
product: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.99.13
is: SBO:0000176

metaR r2332
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is described by: ECO:0000000
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_792f600e_cc3e_4ff9_bb34_56b18f0c0808
is encoded by: hsa:5332
name: PLCB4
constant: false
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: E2QRH8
has only substance units: false

metaM gal e
name: D-Galactose
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB00143
initial concentration: 1.0
is: C00124
is: CHEBI:0
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0
boundary condition: false
constant: false

metaR ACACT10m
type: Reaction
modifier: MODEL1310110002#
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (38.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:676035 NOTES:MM. 2-Methyl-3-acetoacetyl-CoA excreted into urine for patients with disease deficiency
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000134
name: acetyl-CoA C-acetyltransferase, mitochondrial
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: true
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110002#_905b0fe3_3d88_47c3_a973_c0caf5c925b5
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:3081
constant: false
initial amount: NaN
is: Q93099
name: HGD
is: SBO:0000252

metaM dtdp m
has only substance units: false
type: Species
is: SBO:0000247
constant: false
is: CHEBI:58369
is: HMDB01274
is: C00363
name: dTDP
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

metaR H2O2tn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it
reversible: true
reactant: MODEL1310110002#
name: hydrogen peroxide nuclear transport
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110002#

metaR SGPL12r
is version of: http://identifiers.org/ec-code/4.1.2.27
name: Sphingosine-1-phosphate lyase
fast: false
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 4.1.2.27 Confidence Level: 2 AUTHORS: PMID:11018465,PMID:14570870 NOTES:SGPL1 gene as per GeneCards states that hexadecanal is produced - the only way to do this and to maintain charge balance would be to have H2 gas as substrate - remarkably implausible. Due to lack of information to indicate otherwise, added water to breakdown components into ethamp and palmitate NJ
modifier: MODEL1310110002#
reversible: false
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_5dcb7e9a_f50d_4549_95a0_5e1ccd9232a1
name: ST3GAL3
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:6487
initial amount: NaN
has only substance units: false
boundary condition: true

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaR D LACt2
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
product: MODEL1310110002#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
name: D-lactate transport via proton symport
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_fc57f3a4_6e1d_40db_a6be_c50d385bba6d
boundary condition: true
type: Species
is: D9HTE9
initial amount: NaN
initial concentration: NaN
name: SLC25A1
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:6576

metaM cbasp c
is: SBO:0000247
name: N-Carbamoyl-L-aspartate
type: Species
has only substance units: false
is: C00438
notes: FORMULA: C5H6N2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00356 EHMN_ABBREVIATION: C00438
constant: false
is: HMDB00828
is: CHEBI:32814
initial amount: NaN
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_3fcedab3_4714_4863_8409_43fc681db6fa
constant: false
type: Species
name: FADS1
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:3992
has only substance units: false
is: O60427
boundary condition: true

metaM pd3 c
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB06500
boundary condition: false
name: Previtamin D3
has only substance units: false
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaM cs d deg6 l
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 6
is: HMDB00812
is: CHEBI:16953
type: Species
notes: FORMULA: C23H35O27S2 CHARGE: -3
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_6955ce69_ab8d_4803_bdd5_d730562bad6a
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:6513
boundary condition: true
initial amount: NaN
is: P11166
name: SLC2A1
constant: false

metaR r0385
reactant: MODEL1310110002#
fast: false
reversible: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.4 Confidence Level: 0 AUTHORS: PMID:11839747,PMID:12387880,PMID:15576032 NOTES:
name: 3-methyl-2-oxobutanoate:[dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating) EC:1.2.4.4
kinetic law: MODEL1310110002#
product: MODEL1310110002#
type: Reaction

metaM pail45p hs m
name: phosphatidylinositol 4,5-bisphosphate
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:28910
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_99444dab_51a7_43eb_8f9e_2d9ec468086d
is encoded by: hsa:8527
initial concentration: NaN
boundary condition: true
name: DGKD
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM 4mop e
type: Species
is: HMDB00695
constant: false
is: CHEBI:17865
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1
name: 4-methyl-2-oxopentanoate
initial amount: NaN
boundary condition: false

metaR EX pect LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pectins
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_364f0a87_8a37_4023_bed2_a6f6b3102f04
is encoded by: hsa:224
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
constant: false
initial amount: NaN
is: P51648
boundary condition: true
name: ALDH3A2

metaM dcsptn1coa c
is: SBO:0000247
has only substance units: false
boundary condition: false
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
initial amount: NaN
type: Species
constant: false
is: HMDB06513
initial concentration: 1.0
is: C16173
is: http://identifiers.org/pubchem.compound/47205483

metaR DOPAtu
type: Reaction
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#
name: Dopamine uniport
modifier: MODEL1310110002#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
is: SBO:0000185

metaM hdcea l
name: palmitoleate
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:32372
constant: false
is: HMDB03229
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850

metaR MDHm
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
reactant: MODEL1310110002#
type: Reaction
name: malate dehydrogenase, mitochondrial
reversible: true
is described by: ECO:0000134
is: SBO:0000176
modifier: MODEL1310110002#
fast: false
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.37

metaM gam e
boundary condition: false
is: C00329
is: CHEBI:17315
type: Species
is: HMDB01514
constant: false
is: SBO:0000247
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
initial amount: NaN
name: D-Glucosamine
initial concentration: 1.0
has only substance units: false

metaR LEUATB0tc
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of L-Leucine into the intestinal cells by ATB0 transporter
type: Reaction

metaR H2Otly
is described by: ECO:0000000
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110002#
is: SBO:0000185
kinetic law: MODEL1310110002#
reversible: true
type: Reaction
name: H2O transport, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110002#_f168e8a2_4e81_4937_b788_482ab869be3a
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
constant: false
name: _AA526438_1_m
type: Species
is encoded by: hsa:AA526438
initial amount: NaN

metaR r0410
product: MODEL1310110002#
type: Reaction
reversible: true
name: 2-Deoxyguanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
is: SBO:0000176
fast: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_1d01fa3b_26aa_432f_be2b_1a2af284b83d
is encoded by: hsa:H45672
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
name: _H45672_1_m

metaR r0384
reversible: false
kinetic law: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.4.2 Confidence Level: 0 AUTHORS: PMID:10676873 NOTES:
fast: false
name: 2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating) EC:1.2.4.2

http://identifiers.org/biomodels.db/MODEL1310110002#_94a97a2d_6f08_4b79_8f4e_70604416a48c
is encoded by: hsa:56913
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: C1GALT1
type: Species
is: Q9NS00

http://identifiers.org/biomodels.db/MODEL1310110002#_58e394ae_0577_47c8_abdf_969531182f38
is: A6NN98
is encoded by: hsa:8898
type: Species
constant: false
has only substance units: false
name: MTMR2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_89e0893f_71fe_434c_b92e_dda4940f2254
name: HSD3B1
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
is: P14060
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3283

metaM gdp g
is: CHEBI:58189
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB01201
constant: false
name: GDP(3-)
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
type: Species

metaM g3m8masn r
constant: false
notes: FORMULA: C88H147N2O70X CHARGE: 0
initial concentration: 1.0
is: C05873
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_eadc7a17_2dda_412f_8d29_33a2cab7a419
initial amount: NaN
is encoded by: hsa:54995
is: Q9NWU1
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
type: Species
name: OXSM

metaR r0009
is version of: http://identifiers.org/ec-code/3.6.1.1
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110002#

metaM pan4p m
has only substance units: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: HMDB01416
constant: false
boundary condition: false
is: SBO:0000247
name: pantetheine 4'-phosphate(2-)
is: CHEBI:47942
initial concentration: 1.0
initial amount: NaN
type: Species

metaR ME2m
modifier: MODEL1310110002#
is: SBO:0000176
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
is version of: http://identifiers.org/ec-code/1.1.1.38
reversible: false
type: Reaction
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.40
kinetic law: MODEL1310110002#
name: malic enzyme (NADP), mitochondrial
product: MODEL1310110002#

metaR FAOXC103C102m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:3-->C10:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_8eb4f92d_5d80_47f7_9992_af0ba9689a02
is: SBO:0000252
is: P04746
initial concentration: NaN
is encoded by: hsa:279
name: AMY2A
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_6105e561_94c0_4e83_ab44_a805f137a593
name: B3GNT2
is encoded by: hsa:10678
type: Species
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is: Q9NY97

metaR HISSNAT5tc
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR r0627
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110002#
name: Galactosylglycerol galactohydrolase Galactose metabolism EC:3.2.1.22 EC:3.2.1.23
reactant: MODEL1310110002#
is described by: ECO:0000000
reversible: true
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 3.2.1.23 Confidence Level: 0 AUTHORS: PMID:3569296 NOTES:

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_galacgalfucgalacglcgal14acglcgalgluside_hs_g
boundary condition: false
constant: false
is: CHEBI:26174
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C78H135N4O46FULLRCO CHARGE: 0
is: SBO:0000247
name: (Gal)4 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
initial concentration: 1.0

metaM succ m
is: HMDB00254
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C00042
initial concentration: 1.0
name: Succinate
type: Species
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
is: CHEBI:30031
boundary condition: false

metaM udp n
name: UDP(3-)
type: Species
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: CHEBI:58223
boundary condition: false
is: HMDB00295
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_885c618e_7f31_4d1c_844c_2f710a585410
initial concentration: NaN
is: P48448
constant: false
name: ALDH3B2
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:222
type: Species
has only substance units: false
boundary condition: true

metaM 1p3h5c m
boundary condition: false
is: SBO:0000247
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: HMDB01369
is: CHEBI:6151
constant: false
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281

metaR GASNASEly
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: N-glycan degradation EC Number: 3.5.1.26 Confidence Level: 0 AUTHORS: NOTES:NCD
name: glycosylasparaginase, lysosomal
product: MODEL1310110002#
fast: false
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.5.1.26
is: SBO:0000176

metaM cholp c
constant: false
initial amount: NaN
initial concentration: 1.0
name: choline phosphate(1-)
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H13NO4P CHARGE: -1 INCHI: InChI=1S/C5H14NO4P/c1-6(2,3)4-5-10-11(7,8)9/h4-5H2,1-3H3,(H-,7,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00442 EHMN_ABBREVIATION: C00588
type: Species
has only substance units: false
is: CHEBI:295975

metaR FAOXC2051843m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of fatty acid
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3

http://identifiers.org/biomodels.db/MODEL1310110002#_328a5b77_f82d_411a_a3fc_0473d842b306
name: _AI926493_1_c
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species
is encoded by: hsa:AI926493
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_82eea4f2_b6a7_4b7c_beca_5be1098e4fbf
is: Q548A7
has only substance units: false
is encoded by: hsa:65010
boundary condition: true
type: Species
initial concentration: NaN
name: SLC26A6
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_3809efdd_8b98_4dab_9339_dccf16744e86
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is: O95477
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:19
name: ABCA1

http://identifiers.org/biomodels.db/MODEL1310110002#_7ca0b846_200d_4f20_a079_3d390b16bed1
name: ETFB
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is encoded by: hsa:2109
initial amount: NaN
has only substance units: false
constant: false

metaR S23T3g
name: beta-galactoside alpha-2,3-sialyltransferase (complex N-glycan)
is: SBO:0000176
fast: false
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (6487.4) or (6487.9) or (6487.11) or (6487.6) or (6487.7) or (6487.10) or (6487.5) or (6487.1) or (6487.2) or (6487.8) or (6487.3) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.6 Confidence Level: 4 AUTHORS: PMID:8333853 NOTES:NCD
reactant: MODEL1310110002#
modifier: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.4.99.6

metaR THRD L
notes: GENE_ASSOCIATION: (10993.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 4.3.1.19 Confidence Level: 4 AUTHORS: PMID:12361482 NOTES:Previous EC number: 4.2.1.16. New EC number 4.3.1.19. Can't enter this....
reversible: false
modifier: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.3.1.17
type: Reaction
name: L-threonine deaminase
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110002#_563b968c_606e_437d_9fa9_49b830d19939
initial amount: NaN
has only substance units: false
name: ALDH9A1
is: P49189
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:223
boundary condition: true

metaR NDPK6n
modifier: MODEL1310110002#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
type: Reaction
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
product: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110002#_c175937e_3170_4d47_bb75_047c4ee30688
is: P54868
is encoded by: hsa:3158
name: HMGCS2
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false

metaM lnlccoa m
is: HMDB01064
is: http://identifiers.org/pubchem.compound/5462164
name: linoleic coenzyme A
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
is: SBO:0000247

metaM frdp c
is: HMDB00961
has only substance units: false
is: CHEBI:175763
type: Species
name: Farnesyl diphosphate
boundary condition: false
constant: false
initial amount: NaN
is: C00448
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448

http://identifiers.org/biomodels.db/MODEL1310110002#_a1ebb9f0_7402_4f1d_bb27_4de9fc6e6014
boundary condition: true
has only substance units: false
is: P60891
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5631
is: SBO:0000252
name: PRPS1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_69475d0e_0fe2_44c8_8a55_04ac428d6635
type: Species
is encoded by: hsa:5286
is: O00443
is: SBO:0000252
has only substance units: false
name: PIK3C2A
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN

metaR CYSt4
notes: GENE_ASSOCIATION: (11254.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
kinetic law: MODEL1310110002#
is described by: ECO:0000304
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
fast: false
type: Reaction
modifier: MODEL1310110002#
is: SBO:0000185
name: L-cysteine reversible transport via sodium symport

metaM csn e
name: cytosine
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
is: HMDB00630
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:16040

metaR MERCPLACCYSt
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:excretion of 3-mercaptolactate-cysteine disulfide (PMID: 6945862) MM
fast: false
kinetic law: MODEL1310110002#
is described by: ECO:0000000
name: 3-mercaptolactate-cysteine disulfide transport, extracellular
reversible: false
type: Reaction
is: SBO:0000185
reactant: MODEL1310110002#

metaM btn e
has only substance units: false
is: HMDB00030
notes: FORMULA: C10H15N2O3S CHARGE: -1
boundary condition: false
is: CHEBI:3420
is: C00120
is: SBO:0000247
name: Biotin
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false

metaR RE1845C
product: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.65
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
reversible: true
name: RE1845
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_77745070_1536_4647_aeaa_348fadd1a551
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:1716
is: E5KSL6
boundary condition: true
name: DGUOK
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_d016b046_5968_47a4_b4b9_ab76e087324d
is: SBO:0000252
name: GPX4
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:2879
boundary condition: true
is: P36969
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_9422c898_99e4_40ba_b390_0298dc7a83e6
has only substance units: false
is: SBO:0000252
is: Q15147
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:5332
name: PLCB4

metaM dctp n
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:16311
is: HMDB00998
is: SBO:0000247
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
boundary condition: false
name: dCTP
type: Species
is: C00458
has only substance units: false

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

metaM udp l
constant: false
initial amount: NaN
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
name: UDP(3-)
initial concentration: 1.0
has only substance units: false
is: HMDB00295
is: CHEBI:58223
boundary condition: false
is: SBO:0000247
type: Species

metaR r2130
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reversible: true
is described by: ECO:0000000
product: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false

metaM nh4 x
is: CHEBI:28938
is: HMDB00051
is: SBO:0000247
is: C01342
initial amount: NaN
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
type: Species
initial concentration: 1.0
has only substance units: false
name: Ammonium
constant: false

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaR DNDPt29m
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110002#
name: dCDP transport via dADP antiport
reactant: MODEL1310110002#
fast: false
reversible: false
modifier: MODEL1310110002#

metaR r0381
type: Reaction
product: MODEL1310110002#
reversible: true
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Taurine and hypotaurine metabolism EC Number: 1.8.1.3 Confidence Level: 0 AUTHORS: PMID:13979247,PMID:16680556,PMID:7295801 NOTES:
reactant: MODEL1310110002#
fast: false
name: hypotaurine:NAD+ oxidoreductase Taurine and hypotaurine metabolism EC:1.8.1.3
kinetic law: MODEL1310110002#

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_945ce292_e518_4113_bcd4_bb97ebd3c43f
initial amount: NaN
is: O60909
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8704
constant: false
name: B4GALT2
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_f1ba89f9_65d6_4553_80da_05a08252a995
is encoded by: hsa:10331
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is: Q9Y2A9
type: Species
name: B3GNT3
initial concentration: NaN
constant: false

metaR EX 6thf LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hexaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_3f19bd93_da90_4035_ba58_5e26ad55369c
is: P03897
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: ND3
is encoded by: hsa:4537
type: Species
has only substance units: false
is: SBO:0000252

metaR G14T19g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
type: Reaction
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_9a68f641_f36c_4f21_a3e6_4fe52fe588d2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: SDHB
type: Species
initial amount: NaN
constant: false
has only substance units: false
is: P21912
is encoded by: hsa:6390

metaR IDPtn
name: IDP nuclear transport
is: SBO:0000185
reversible: true
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000

metaR S6TASE5ly
is version of: http://identifiers.org/ec-code/3.4.16.5
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
reversible: true
fast: false
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
reactant: MODEL1310110002#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.4
name: N-acetylgalactosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110002#_25490afb_44b0_430c_9349_608daf5f51c6
name: ALPI
has only substance units: false
is: SBO:0000252
is: P09923
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:248
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_0648818b_9cf7_48ab_8c62_63416dbfd72b
name: COX2
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
is: Q7GXZ8
is encoded by: hsa:4513

metaR r0236
is described by: ECO:0000000
name: 5,6-Dihydrouracil:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
is: SBO:0000176
reactant: MODEL1310110002#
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
is version of: http://identifiers.org/ec-code/3.5.1.6
notes: GENE_ASSOCIATION: (AI640625.1) or (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500 NOTES:
fast: false
product: MODEL1310110002#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_a6354a52_b84d_4035_9b20_2d25d9b5938b
has only substance units: false
initial amount: NaN
type: Species
name: _AI824319_1_r
initial concentration: NaN
boundary condition: true
is encoded by: hsa:AI824319
constant: false
is: SBO:0000252

metaR FAOXC10C8m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)m
type: Reaction

metaM cytd e
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: C00475
boundary condition: false
has only substance units: false
name: Cytidine
is: CHEBI:17562
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00089
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_ddfcbd28_9863_4e5f_8fb8_4d4a7a913da4
type: Species
constant: false
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: ST3GAL1
is encoded by: hsa:6482
is: Q11201
initial amount: NaN

metaR r2131
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110002#
is: SBO:0000185
type: Reaction

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

metaR RE2998M
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
name: RE2998
product: MODEL1310110002#
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110002#
fast: false
modifier: MODEL1310110002#
reactant: MODEL1310110002#

metaR FUT14g
reversible: false
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
product: MODEL1310110002#
kinetic law: MODEL1310110002#
name: Galactoside 2-alpha-L-fucosyltransferase 1
reactant: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.1.69

metaR NDPK6m
fast: false
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
reversible: true
type: Reaction
is described by: ECO:0000254
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
product: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#

metaR FAOXC81C61m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaR ST8SIA11
is version of: http://identifiers.org/ec-code/2.4.99.8
reversible: false
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
name: Beta-galactoside alpha-2,3-sialyltransferase
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000000

metaM sql r
has only substance units: false
is: CHEBI:15440
boundary condition: false
name: squalene
initial concentration: 1.0
is: HMDB00256
is: SBO:0000247
notes: FORMULA: C30H50 CHARGE: 0 INCHI: InChI=1S/C30H50/c1-25(2)15-11-19-29(7)23-13-21-27(5)17-9-10-18-28(6)22-14-24-30(8)20-12-16-26(3)4/h15-18,23-24H,9-14,19-22H2,1-8H3/b27-17+,28-18+,29-23+,30-24+ HEPATONET_1.0_ABBREVIATION: HC00526 EHMN_ABBREVIATION: C00751
type: Species
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_0e2603ad_c9e1_4369_ad7b_165dee222404
type: Species
is encoded by: hsa:D29675
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: _D29675_1_e
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_e5c9beb8_c4cd_4eba_abd4_ce179351748d
name: FASN
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is: P49327
initial concentration: NaN
is encoded by: hsa:2194
has only substance units: false

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_c272230c_0651_4b52_99a0_d823380c6a72
constant: false
initial concentration: NaN
name: SPTLC1:SPTLC2
is encoded by: hsa:10558
is: SBO:0000297
is encoded by: hsa:9517
initial amount: NaN
boundary condition: true
has part: O15270
type: Species
has part: O15269
has only substance units: false

metaR RETH
type: Reaction
fast: false
reactant: MODEL1310110002#
name: retinyl ester hydrolase
product: MODEL1310110002#
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
is version of: http://identifiers.org/ec-code/3.1.1.3
is described by: ECO:0000000
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#

metaR ASPTAm
kinetic law: MODEL1310110002#
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110002#
is described by: ECO:0000269
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:6930651 NOTES:NCD
name: aspartate transaminase
modifier: MODEL1310110002#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_d1d6951a_66f8_41bc_a7ba_2dcca9cf4197
has only substance units: false
boundary condition: true
is encoded by: hsa:6480
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: P15907
name: ST6GAL1

http://identifiers.org/biomodels.db/MODEL1310110002#_f467ce22_085a_41dc_b753_87c8a8b952c4
name: SLC5A10
is: A0PJK1
is encoded by: hsa:125206
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

metaM gdp n
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:58189
is: SBO:0000247
name: GDP(3-)
is: HMDB01201

metaR AHEXASEly
reversible: false
is: SBO:0000176
modifier: MODEL1310110002#
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR TCYNTt
is: SBO:0000185
type: Reaction
reversible: false
reactant: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
name: Thiocyanate transport via diffusion (cytosol to extracellular)
kinetic law: MODEL1310110002#
fast: false

metaR SR5ARr
reversible: false
is described by: ECO:0000134
type: Reaction
product: MODEL1310110002#
name: 3-oxo-5-alpha-steroid 4-dehydrogenase
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.99.5
notes: GENE_ASSOCIATION: (6716.1) or (6715.1) SUBSYSTEM: Steroid metabolism EC Number: 1.3.99.5 Confidence Level: 4 AUTHORS: PMID:2339109 NOTES:there are actually two types, but the difference between them lies in optimal pH function - grouped as one reaction at his point to eliminate redundancy. NADP known to be cofactor NJ. human 5alpha-HSD activity determined in transfected COS cells using C-14 labelled testosterone as substrate
kinetic law: MODEL1310110002#
fast: false
is: SBO:0000176

metaM ptth c
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831
has only substance units: false
is: CHEBI:16753
type: Species
is: HMDB03426
name: pantetheine
boundary condition: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_5df37e19_964d_4f17_9642_2952068bc440
name: PIP5K1C
is: SBO:0000252
is encoded by: hsa:23396
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: O60331

http://identifiers.org/biomodels.db/MODEL1310110002#_300a32d3_592e_443d_8760_8dbef46d2a51
name: PIK3C3
constant: false
type: Species
initial amount: NaN
is: Q8NEB9
is encoded by: hsa:5289
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaM fmn c
is: SBO:0000247
has only substance units: false
name: FMN
is: CHEBI:58210
boundary condition: false
initial amount: NaN
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
type: Species
initial concentration: 1.0
is: C00061
is: HMDB01520
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_738f486c_50c7_4438_bd39_cea7966a7ad9
type: Species
boundary condition: true
name: HMGCL
has only substance units: false
is encoded by: hsa:3155
is: Q6IBC0
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN

metaR RE2973C
name: RE2973
product: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5290.1) or (5291.1) or (5294.1) or (5289.1) or (5286.1) or (5287.1) or (5288.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 0 AUTHORS: PMID:10358929,PMID:11493657,PMID:9043658,PMID:9211928 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.137
fast: false
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.1.154
is version of: http://identifiers.org/ec-code/2.7.11.1
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.1.153

http://identifiers.org/biomodels.db/MODEL1310110002#_7b38aaaa_8274_4463_a9a5_a6e60a6b7b23
is encoded by: hsa:7991
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
name: TUSC3
is: SBO:0000252
initial concentration: NaN

metaM arab L c
is: SBO:0000247
is: CHEBI:30849
has only substance units: false
boundary condition: false
initial amount: NaN
name: L-arabinose
notes: FORMULA: C5H10O5 CHARGE: 0
type: Species
constant: false
initial concentration: 1.0
is: HMDB00646

metaM 4mop c
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB00695
constant: false
is: SBO:0000247
notes: FORMULA: C6H9O3 CHARGE: -1 INCHI: InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00211 EHMN_ABBREVIATION: C00233
is: CHEBI:17865
boundary condition: false
name: 4-methyl-2-oxopentanoate

metaR FAOXC2251836m
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
name: Beta oxidation of fatty acid
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR PFK
name: phosphofructokinase
reversible: false
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (5214.1) or (5211.2) or (5214.1 and 5211.1) or (5214.1 and 5213.1) or (5213.1) or (5214.1 and 5211.2) or (5211.1) or (5211.1 and 5213.1) or (5213.1 and 5211.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000304
reactant: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.1.11

http://identifiers.org/biomodels.db/MODEL1310110002#_cef2e940_96ec_4abf_a59e_b6c071379412
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: HK1
is encoded by: hsa:3098
is: P78542
boundary condition: true
is: SBO:0000252
initial concentration: NaN

metaM mlthf m
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
is: HMDB01533
has only substance units: false
name: 5,10-Methylenetetrahydrofolate
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:15636
boundary condition: false
is: C00143

metaR G14T3g
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
product: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110002#

metaM gdp m
is: CHEBI:58189
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
is: HMDB01201
name: GDP
type: Species
boundary condition: false
is: C00035
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
constant: false

metaR UDPACGALtl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - there are UDPACGAL-translocators for ER and Golgi, however no info on lysosomal - poor support for this NJ
product: MODEL1310110002#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
name: udpacgal intracellular transport
fast: false
kinetic law: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR EX 10fthf LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-Formyltetrahydrofolate exchange
type: Reaction

metaM xan c
constant: false
notes: FORMULA: C5H4N4O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00320 EHMN_ABBREVIATION: C00385
initial amount: NaN
is: HMDB00292
name: Xanthine
is: C00385
type: Species
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:17712

metaM pect e
boundary condition: false
constant: false
initial amount: NaN
name: pectins
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C2535H3509O2535 CHARGE: -1
is: HMDB03402
initial concentration: 1.0

metaR LEUPHELAT2tc
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Leucine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

metaM fmn e
is: C00061
has only substance units: false
is: HMDB01520
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C17H19N4O9P CHARGE: -2
name: FMN
constant: false
is: CHEBI:58210
boundary condition: false
is: SBO:0000247

metaM 4hpro LT m
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB00725
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
initial amount: NaN
is: CHEBI:18095
boundary condition: false
constant: false
name: trans-4-hydroxy-L-proline

http://identifiers.org/biomodels.db/MODEL1310110002#_272c4bab_eab9_4826_8cbc_bb6a3ae0882f
is: P16219
initial concentration: NaN
boundary condition: true
is encoded by: hsa:35
name: ACADS
is: SBO:0000252
type: Species
initial amount: NaN
constant: false
has only substance units: false

metaM but e
initial amount: NaN
is: CHEBI:17968
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
is: HMDB00039
name: butyrate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_f89eaedb_4aea_4789_b30c_3660eb2f4a97
is: O75251
constant: false
is encoded by: hsa:374291
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: NDUFS7
initial amount: NaN
has only substance units: false

metaM arab L e
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00646
name: L-arabinose
notes: FORMULA: C5H10O5 CHARGE: 0
initial amount: NaN
is: SBO:0000247
is: CHEBI:30849
type: Species

metaM damp c
is: HMDB00905
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false
name: dAMP(2-)
is: CHEBI:58245
has only substance units: false
notes: FORMULA: C10H12N5O6P CHARGE: -2 INCHI: InChI=1S/C10H14N5O6P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19)/p-2/t5-,6+,7+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00304 EHMN_ABBREVIATION: C00360
initial amount: NaN
type: Species

metaM orot c
is: SBO:0000247
constant: false
is: HMDB00226
type: Species
has only substance units: false
is: C00295
is: CHEBI:30839
name: Orotate
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
boundary condition: false
initial concentration: 1.0
initial amount: NaN

metaR CDIPTr
is described by: ECO:0000000
reactant: MODEL1310110002#
reversible: true
is: SBO:0000176
name: phosphatidylinositol synthase (Homo sapiens)
is version of: http://identifiers.org/ec-code/2.7.8.11
notes: GENE_ASSOCIATION: (10423.1) or (10423.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.11 Confidence Level: 4 AUTHORS: PMID:2425833 NOTES:NJ - reversibility of enzyme found in lit by NCD
kinetic law: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
product: MODEL1310110002#
fast: false

metaR PI45P5Pn
is: SBO:0000176
product: MODEL1310110002#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase, nuclear
type: Reaction
fast: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 2 AUTHORS: PMID:12728269 NOTES:NCD
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_2b42252e_5a41_45f5_ba5d_c534fc4f053a
is: E7EUT4
initial amount: NaN
is: SBO:0000252
name: GAPDH
is encoded by: hsa:2597
type: Species
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN

metaM sph1p e
constant: false
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial amount: NaN
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB01383
is: CHEBI:57939
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate

metaR RE1533M
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1533
reversible: true
reactant: MODEL1310110002#

metaM 3hexdtetcoa m
is: SBO:0000247
boundary condition: false
constant: false
type: Species
has only substance units: false
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
is: HMDB02288
name: 3,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
initial concentration: 1.0

metaR r0512
reactant: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
fast: false
kinetic law: MODEL1310110002#
name: Dihydrofolate:NAD+ oxidoreductase Folate biosynthesis EC:1.5.1.3
is: SBO:0000176
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.4.1
modifier: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_29292049_48dd_4468_b3ca_303485e03c49
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:4722
boundary condition: true
type: Species
is: O75489
has only substance units: false
name: NDUFS3

metaR MMMm
is: SBO:0000176
name: methylmalonyl-CoA mutase
reactant: MODEL1310110002#
type: Reaction
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/5.4.99.2
kinetic law: MODEL1310110002#
reversible: true
modifier: MODEL1310110002#

metaR r2361
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
name: Organic anion transporter 5 Utilized transport

metaM k c
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
name: potassium
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: C00238
is: CHEBI:29103
is: HMDB00586

metaM HC02179 e
type: Species
is: SBO:0000247
name: 20-hydroxy-arachidonate
is: CHEBI:34306
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_5738fb8b_070c_46db_bdc2_be821e8b60cc
is encoded by: hsa:23236
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
name: PLCB1
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM leugly e
is: http://identifiers.org/pubchem.compound/97364
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
name: Leucylglycine
notes: FORMULA: C8H16N2O3 CHARGE: 0
initial amount: NaN
constant: false
has only substance units: false

metaM glyclt c
name: glycolate
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
boundary condition: false
initial amount: NaN
is: HMDB00115
has only substance units: false
is: CHEBI:29805

http://identifiers.org/biomodels.db/MODEL1310110002#_b9cfdfab_5c67_4e08_bcc5_30ab613737a3
is: Q96QD8
is encoded by: hsa:54407
has only substance units: false
type: Species
initial amount: NaN
constant: false
boundary condition: true
name: SLC38A2
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_cdf1ac28_2d6b_4937_8090_bb9d8a952f7a
is: SBO:0000252
type: Species
has only substance units: false
is: O75354
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:955
name: ENTPD6
initial amount: NaN

metaR DGSNtm
name: deoyguanosine transport in mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:3696164 NOTES:
type: Reaction
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#

metaM dtdp e
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
initial amount: NaN
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: CHEBI:58369
is: HMDB01274
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_5f69c946_8303_4435_aca4_1490b90c196e
constant: false
is encoded by: hsa:4645
boundary condition: true
is: SBO:0000252
name: MYO5B
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q9H6Y6
type: Species

metaR DNDPt18m
product: MODEL1310110002#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110002#
name: dUDP transport via ADP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
fast: false
is: SBO:0000185
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#

metaR LNLNCAt
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
kinetic law: MODEL1310110002#
name: fatty acid transport via diffusion
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110002#
fast: false
is described by: ECO:0000000

metaM dectricoa m
notes: FORMULA: C31H44N7O17P3S CHARGE: -4
constant: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/16019966
name: 2,4,7-decatrienoylcoa
type: Species

metaM dpcoa c
type: Species
constant: false
initial amount: NaN
is: CHEBI:57328
is: HMDB01373
initial concentration: 1.0
boundary condition: false
is: C00882
has only substance units: false
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: SBO:0000247
name: Dephospho-CoA

metaR MAN6PI
modifier: MODEL1310110002#
is: SBO:0000176
name: mannose-6-phosphate isomerase
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/5.3.1.8
fast: false
reversible: true
is described by: ECO:0000304
type: Reaction
reactant: MODEL1310110002#
product: MODEL1310110002#

metaR r1660
fast: false
product: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110002#

metaR CYTK11n
product: MODEL1310110002#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
is: SBO:0000176
fast: false
name: cytidylate kinase (dCMP,dGTP),nuclear
reversible: true

metaR r2360
product: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110002#
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185
fast: false
type: Reaction

metaM pail45p hs c
has only substance units: false
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false
name: phosphatidylinositol 4,5-bisphosphate
is: CHEBI:28910
initial amount: NaN
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637

metaM C05279 m
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: CHEBI:28387
has only substance units: false
name: trans,cis-Lauro-2,6-dienoyl-CoA
is: HMDB11123
initial concentration: 1.0

metaM nad r
has only substance units: false
is: HMDB00902
initial concentration: 1.0
name: NAD(1-)
is: CHEBI:57540
boundary condition: false
constant: false
notes: FORMULA: C21H26N7O14P2 CHARGE: -1 INCHI: InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/p-1/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00013 EHMN_ABBREVIATION: C00003
type: Species
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_87934210_64c4_4d7b_b416_7203f767a1e5
has only substance units: false
is encoded by: hsa:5297
constant: false
is: B4DYG5
type: Species
name: PI4KA
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN

metaM but c
boundary condition: false
is: CHEBI:17968
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
constant: false
has only substance units: false
name: butyrate
is: HMDB00039

metaR FAOXC164C165m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_df807960_f01b_44a3_ba00_2727447f8bd8
boundary condition: true
is encoded by: hsa:4860
name: PNP
is: SBO:0000252
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: P00491
constant: false

metaM fdp c
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:16905
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
has only substance units: false
is: HMDB01058
type: Species
initial concentration: 1.0
is: SBO:0000247
is: C00354
name: D-Fructose 1,6-bisphosphate
is: http://identifiers.org/pubchem.compound/3647

http://identifiers.org/biomodels.db/MODEL1310110002#_1dc36fed_698e_4521_8dd2_03f4c46baeca
constant: false
name: SLC35A2
boundary condition: true
initial concentration: NaN
is: P78381
has only substance units: false
is encoded by: hsa:7355
is: SBO:0000252
type: Species
initial amount: NaN

metaR CYTK3n
is described by: ECO:0000269
is: SBO:0000176
fast: false
product: MODEL1310110002#
modifier: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,CTP),nuclear

metaM dcsptn1coa m
is: HMDB06513
is: SBO:0000247
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
boundary condition: false
initial amount: NaN
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205483
initial concentration: 1.0
is: C16173
has only substance units: false
constant: false

metaM 7thf e
name: heptaglutamyl folate (THF)
has only substance units: false
boundary condition: false
is: HMDB06559
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
notes: FORMULA: C49H57N13O24 CHARGE: -8

metaR EX malt LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltose exchange
type: Reaction

metaM leugly c
constant: false
notes: FORMULA: C8H16N2O3 CHARGE: 0
is: http://identifiers.org/pubchem.compound/97364
initial concentration: 1.0
has only substance units: false
name: Leucylglycine
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species

metaR LNLCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110002#
name: Linoleic acid (n-C18:2) transport in via diffusion

metaM k e
has only substance units: false
initial concentration: 1.0
is: C00238
is: HMDB00586
is: CHEBI:29103
constant: false
name: potassium
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_6f748e14_92b9_46c2_827c_19ecd1a609e3
is encoded by: hsa:AA177072
is: SBO:0000252
name: _AA177072_1_x
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR 5MTHFt2le
type: Reaction
product: MODEL1310110002#
fast: false
is described by: ECO:0000134
reactant: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110002#
name: 5-methyltetrahydrofolate transport via anion exchange
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_23996526_36cb_4b86_ac77_eff946cf7ae3
is: O15056
initial amount: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8871
boundary condition: true
constant: false
name: SYNJ2
initial concentration: NaN
type: Species

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_4fb8d0d6_87aa_4c08_82ad_7e02bd0f1ea4
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: O75752
has only substance units: false
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:8706
name: B3GALNT1

http://identifiers.org/biomodels.db/MODEL1310110002#_2155d6e3_7dba_49c7_aa6f_b494af15e681
boundary condition: true
is: P35219
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
name: CA8
is encoded by: hsa:767
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_598ea1dc_20c5_4b51_b0fb_128f778f76ac
initial amount: NaN
constant: false
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:1375
name: CPT1B
is: Q92523
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_c08fa257_dbf8_42c6_85fa_b030a03c29d9
is: A0S0A7
has only substance units: false
initial concentration: NaN
is encoded by: hsa:4846
initial amount: NaN
constant: false
name: NOS3
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_8d43eabe_def2_407f_a941_e41760aeea36
constant: false
boundary condition: true
type: Species
is: P82251
is encoded by: hsa:11136
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: SLC7A9
initial concentration: NaN

metaM HC01415 m
initial amount: NaN
is: CHEBI:27537
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O17P3S/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36/h8-9,16-18,22-24,28,39-40H,4-7,10-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/b9-8+/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05276
name: (2E)-Octenoyl-CoA
has only substance units: false
boundary condition: false
type: Species
constant: false

metaM dgsn m
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: C00330
is: SBO:0000247
name: Deoxyguanosine
is: CHEBI:17172
boundary condition: false
is: HMDB00085
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: 1.0

metaR FAOXC16DCC14DCx
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16DC-->C14DC)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_3a4e8b53_4a95_4558_8b6c_077f73065fb1
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: _AA532636_1_m
type: Species
is encoded by: hsa:AA532636
has only substance units: false
initial amount: NaN

metaR B MANNASEly
product: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.25
kinetic law: MODEL1310110002#
type: Reaction
name: beta-mannosidase, lysosomal
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110002#_3c6b376e_4705_482a_89a8_262c61643734
name: _J03866_1_m
constant: false
type: Species
is encoded by: hsa:J03866
boundary condition: true
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_17ccc4a2_023e_419c_9199_d896fe3f2137
type: Species
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3030
constant: false
is: E9KL44
name: HADHA
boundary condition: true
has only substance units: false

metaM cytd c
is: HMDB00089
name: Cytidine
is: C00475
is: CHEBI:17562
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C9H13N3O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_316ff803_30a0_4d53_acf9_76a47adfbf49
type: Species
constant: false
is: SBO:0000252
is: P22413
initial concentration: NaN
boundary condition: true
is encoded by: hsa:5167
initial amount: NaN
has only substance units: false
name: ENPP1

http://identifiers.org/biomodels.db/MODEL1310110002#_0677f4bd_2718_4f23_8454_1b26199beffc
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:AI640625
is: SBO:0000252
has only substance units: false
name: _AI640625_1_c
boundary condition: true

metaM hdcea r
constant: false
type: Species
is: CHEBI:32372
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB03229
initial concentration: 1.0
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
name: palmitoleate
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_bbd5eecf_b1ec_46c2_8257_511030d4dd47
is: P19961
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:280
is: SBO:0000252
name: AMY2B
constant: false
initial concentration: NaN

metaR NACHEXA6ly
name: beta-N-acetylhexosaminidase A, lysosomal
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD
is described by: ECO:0000000
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_a4822d52_7df9_47b3_b616_d64d865e82cb
type: Species
initial concentration: NaN
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:4731
name: NDUFV3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_f7ba1b8e_5cee_4e81_a669_356f359cc033
name: SUOX
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
is: P51687
is encoded by: hsa:6821

metaR CO2ter
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
name: CO2 endoplasmic reticular transport via diffusion
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: true

metaR AG13T2g
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176

metaR DNDPt35m
fast: false
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
kinetic law: MODEL1310110002#
product: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000269
name: dGDP transport via dADP antiport
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_0c4da3aa_aff7_4ada_ac43_3a48b65c05f8
name: AADAT
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
constant: false
is: Q4W5N8
type: Species
has only substance units: false
is encoded by: hsa:51166

http://identifiers.org/biomodels.db/MODEL1310110002#_054d1644_f508_48c7_88ed_1928d2635b99
name: PPCS
initial amount: NaN
initial concentration: NaN
is: Q9HAB8
is encoded by: hsa:79717
constant: false
boundary condition: true
is: SBO:0000252
type: Species
has only substance units: false

metaR ECOAH12m
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
reversible: true
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000304
fast: false
reactant: MODEL1310110002#
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
product: MODEL1310110002#
is: SBO:0000176

metaM ala L e
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
has only substance units: false
name: L-alanine
constant: false
is: HMDB00161
initial concentration: 1.0
is: CHEBI:16977
type: Species
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_aff23437_0e67_4b82_965a_5e6e7be6b818
name: SDS
initial concentration: NaN
is: P20132
constant: false
has only substance units: false
type: Species
is encoded by: hsa:10993
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaM HC00900 c
is: CHEBI:30860
type: Species
has only substance units: false
name: Methylmalonate
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_3628dd9c_09cf_44d7_b054_82b18c35daa0
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

metaR M4MPDOL Uter
reversible: false
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110002#
name: m4mpdol flippase
is: SBO:0000185
type: Reaction
product: MODEL1310110002#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_37b18f3c_3917_44f9_a028_73109fb53411
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:AU149534
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: _AU149534_1_e
type: Species

metaR RE1342C
kinetic law: MODEL1310110002#
fast: false
reversible: true
product: MODEL1310110002#
reactant: MODEL1310110002#
name: RE1342
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton
type: Reaction
is described by: ECO:0000000

metaM xol7ah c
is: HMDB06892
constant: false
is: SBO:0000247
is: CHEBI:2290
type: Species
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
boundary condition: false
has only substance units: false
name: 7alpha-hydroxy-5beta-cholestan-3-one
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_216653b2_098f_45a8_afa3_9ad4e7d23237
initial amount: NaN
is encoded by: hsa:84693
boundary condition: true
name: MCEE
is: SBO:0000252
is: Q96PE7
has only substance units: false
type: Species
constant: false
initial concentration: NaN

metaM succ c
constant: false
is: SBO:0000247
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
name: Succinate
is: CHEBI:30031
type: Species
boundary condition: false
initial concentration: 1.0
is: C00042
has only substance units: false
initial amount: NaN
is: HMDB00254

metaR PROSTGF2t
product: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
fast: false
is described by: ECO:0000269
modifier: MODEL1310110002#
reversible: true
name: prostaglandin uniport

http://identifiers.org/biomodels.db/MODEL1310110002#_e7109284_c1f9_4f5b_b7ec_d6e1b263ccf8
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110002#_124503b9_5440_4bc7_96f4_1a5015d257df
is encoded by: hsa:2110
initial concentration: NaN
constant: false
name: ETFDH
boundary condition: true
has only substance units: false
is: Q16134
initial amount: NaN
is: SBO:0000252
type: Species

metaM malthx e
is: SBO:0000247
type: Species
is: C01936
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
constant: false
name: Maltohexaose
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
initial amount: NaN
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_5d2a55e1_4ec9_44d0_ab3c_6a3944f736f7
initial concentration: NaN
name: _AI291895_1_c
has only substance units: false
boundary condition: true
is encoded by: hsa:AI291895
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

metaM nad m
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00902
is: C00003
is: CHEBI:57540
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide
boundary condition: false
is: http://identifiers.org/pubchem.compound/3305
constant: false
is: SBO:0000247

metaM ksi pre3 g
is: C00130
is: HMDB00175
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 3
constant: false
boundary condition: false
type: Species
is: CHEBI:58053
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C93H152N6O67X CHARGE: -1

metaM creat c
is: CHEBI:16919
initial concentration: 1.0
boundary condition: false
name: creatine
type: Species
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: HMDB00064
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_f000d179_a612_4603_8e38_3d3cb8a681c5
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:224
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
is: P51648
name: ALDH3A2

metaM mlthf c
type: Species
is: HMDB01533
initial concentration: 1.0
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial amount: NaN
constant: false
is: CHEBI:15636
boundary condition: false
has only substance units: false
is: C00143
is: SBO:0000247
name: 5,10-Methylenetetrahydrofolate

metaM btn c
name: Biotin
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: C00120
constant: false
is: CHEBI:3420
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1
has only substance units: false
is: HMDB00030

metaM gdp c
is: C00035
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
type: Species
is: HMDB01201
has only substance units: false
name: GDP
is: CHEBI:58189
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_19a4a60e_9ff2_407a_b8d4_c12b2a8b6ba2
is: P31213
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:6716
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
name: SRD5A2

http://identifiers.org/biomodels.db/MODEL1310110002#_f2464c0c_871f_4e8c_977c_552b50cecedc
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
name: NDUFA3
is encoded by: hsa:4696
is: O95167
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_9f2aa91b_e2ee_4544_9cc3_695979a3465e
is encoded by: hsa:6392
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
name: SDHD
is: O14521
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_da99aeea_5bb5_4d65_8527_d972531fb590
is encoded by: hsa:10588
has only substance units: false
initial amount: NaN
type: Species
is: P49914
boundary condition: true
constant: false
initial concentration: NaN
is: SBO:0000252
name: MTHFS

metaR B3GNT312g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
fast: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000254
reversible: false
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
type: Reaction
reactant: MODEL1310110002#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110002#_2786ec16_0fc6_4eac_9c08_5ebecb40b2f7
is encoded by: hsa:443
is: Q6FH48
has only substance units: false
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: ASPA

metaR RE2660C
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
name: RE2660
is described by: ECO:0000000
fast: false

metaR r1664
type: Reaction
is: SBO:0000185
name: Y+LAT2 Utilized transport
fast: false
product: MODEL1310110002#
modifier: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_9acf1305_f651_4f17_b598_5858b0b45d1e
is: O00142
name: TK2
constant: false
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:7084
has only substance units: false

metaM h2o e
constant: false
initial concentration: 1.0
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: HMDB02111
initial amount: NaN
has only substance units: false
type: Species
is: C00001
is: SBO:0000247
boundary condition: false
is: CHEBI:15377
name: H2O

metaR MALSO4tm
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
kinetic law: MODEL1310110002#
reversible: true
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
is described by: ECO:0000269
name: Malate:sulfate antiport, mitochondrial
type: Reaction
is: SBO:0000185
modifier: MODEL1310110002#

metaM 44mctr r
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
is: CHEBI:17813
is: HMDB01023
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_6febedfe_0fe2_4acf_a928_5fbc53ae7ca2
is: P09972
name: ALDOC
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:230

metaM HC01842 c
boundary condition: false
initial concentration: 1.0
name: Phosphodimethylethanolamine
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)
is: CHEBI:31997
type: Species
is: SBO:0000247

metaR r0517
kinetic law: MODEL1310110002#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
modifier: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
fast: false
product: MODEL1310110002#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.17.4.1
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:

metaR PHEyLATthc
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Phenylalanine by y+LAT1 or y+LAT2 with co-transporter of h in small intestine and kidney
type: Reaction

metaR EX acald LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetaldehyde exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_ede04650_857c_4642_8e79_b5c02bd31779
is: O43677
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: NDUFC1
type: Species
boundary condition: true
is encoded by: hsa:4717

metaR 3SPYRSPm
is: SBO:0000176
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM
reactant: MODEL1310110002#
type: Reaction
fast: false
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial

metaM sph1p c
initial concentration: 1.0
type: Species
notes: FORMULA: C18H39NO5P CHARGE: -1 INCHI: InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/p-1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00675 EHMN_ABBREVIATION: C01120
initial amount: NaN
boundary condition: false
is: HMDB01383
is: CHEBI:57939
name: (2S,3R)-2-azaniumyl-3-hydroxyoctadecyl phosphate
has only substance units: false
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_a23942cb_d203_4cba_9b38_df04331436f6
initial concentration: NaN
type: Species
has only substance units: false
name: CHST5
is encoded by: hsa:23563
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_ec93be5a_271a_41ec_a9e0_c800fd8f01d6
is: SBO:0000252
is: O75038
is encoded by: hsa:9651
type: Species
constant: false
name: PLCH2
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true

metaM ala L c
constant: false
name: L-alanine
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00161
has only substance units: false
is: CHEBI:16977
initial amount: NaN
boundary condition: false

metaR NCNt
is: SBO:0000185
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
product: MODEL1310110002#
type: Reaction
name: Na+/Ca2+-NH4+ exchange
reactant: MODEL1310110002#
reversible: true

metaM xylu L c
boundary condition: false
is: SBO:0000247
is: HMDB00751
constant: false
is: CHEBI:17399
type: Species
name: L-xylulose
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
initial concentration: 1.0

metaM 4hpro LT e
initial concentration: 1.0
name: trans-4-hydroxy-L-proline
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
is: SBO:0000247
is: HMDB00725
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false

metaM 3ddecdicoa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB03952
is: C05280
is: SBO:0000247
name: 3,6-dodecadienoylcoa
type: Species
initial concentration: 1.0
constant: false

metaM dha e
is: CHEBI:16016
has only substance units: false
is: SBO:0000247
boundary condition: false
name: glycerone
constant: false
is: HMDB01882
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_35b03804_f957_4060_9b0e_9d16e6a33e2e
type: Species
is encoded by: hsa:9187
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
name: SLC24A1
has only substance units: false
is: B4DUG1

metaR HEXDIACTD
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

metaR r1661
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110002#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110002#

metaM udp r
has only substance units: false
constant: false
initial concentration: 1.0
is: SBO:0000247
name: UDP
is: HMDB00295
is: CHEBI:58223
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
is: C00015
initial amount: NaN
boundary condition: false

metaM 2mp2coa m
name: 2-Methylprop-2-enoyl-CoA
has only substance units: false
is: SBO:0000247
is: CHEBI:27754
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
constant: false
is: HMDB01011

http://identifiers.org/biomodels.db/MODEL1310110002#_9378bd08_1ee5_4afc_b8a8_596386fa539f
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:8867
name: SYNJ1
type: Species
is: O43426
has only substance units: false

metaR RE1526M
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
fast: false
is described by: ECO:0000000
name: RE1526

http://identifiers.org/biomodels.db/MODEL1310110002#_e4c0b82f_4051_484e_a18a_818cf51a6d95
type: Species
name: ALAS1
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:211
is: P13196
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR r2401
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
fast: false
reversible: false

metaR S6T1g
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: false
reactant: MODEL1310110002#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_d2874b6a_f0f5_485a_ad5d_b5c198f5f071
type: Species
boundary condition: true
is: A8K761
initial amount: NaN
is encoded by: hsa:4716
initial concentration: NaN
name: NDUFB10
constant: false
is: SBO:0000252
has only substance units: false

metaM lnlccoa r
name: linoleic coenzyme A
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+ HEPATONET_1.0_ABBREVIATION: HC01983
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB01064
constant: false
is: http://identifiers.org/pubchem.compound/5462164
initial concentration: 1.0
is: SBO:0000247

metaM c12dccoa x
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
name: dodecanedioylcoa
notes: FORMULA: C33H51N7O19P3S CHARGE: -5
boundary condition: false
is: SBO:0000247
is: HMDB04047
is: C14143
has only substance units: false

metaM dtdp c
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
constant: false
is: HMDB01274
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:58369
name: dTDP
is: C00363
type: Species
initial amount: NaN
is: SBO:0000247

metaR UAG4E
is: SBO:0000176
type: Reaction
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/5.1.3.2
reversible: true
fast: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000304
name: UDP-N-acetylglucosamine 4-epimerase
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Aminosugar metabolism EC Number: 5.1.3.7 Confidence Level: 2 AUTHORS: NOTES:NCD

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

metaR r1876
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110002#
name: Y+LAT2 Utilized transport
product: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#

metaR 2HBO
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.27
type: Reaction
reactant: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
reversible: true
fast: false
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
is described by: ECO:0000269

metaM creat e
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: creatine
is: HMDB00064
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C4H9N3O2 CHARGE: 0 INCHI: InChI=1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9) HEPATONET_1.0_ABBREVIATION: HC00260 EHMN_ABBREVIATION: C00300
is: CHEBI:16919

http://identifiers.org/biomodels.db/MODEL1310110002#_77840246_b40c_4612_98d9_190823693805
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AA526438
has only substance units: false
name: _AA526438_1_c
initial concentration: NaN
constant: false

metaM m6mpdol U r
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:37635
initial amount: NaN
has only substance units: false
constant: false
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
notes: FORMULA: C1605H2640N20O520P20 CHARGE: -20

http://identifiers.org/biomodels.db/MODEL1310110002#_e827cd8e_3bfa_4c21_87f9_234a948e0e42
is: SBO:0000252
name: MAN2A1
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:4124
boundary condition: true
is: Q16706
initial amount: NaN

metaM h2o c
is: SBO:0000247
notes: FORMULA: H2O CHARGE: 0
initial concentration: 1.0
has only substance units: false
constant: false
type: Species
is: C00001
initial amount: NaN
is: HMDB02111
name: H2O
boundary condition: false
is: CHEBI:3303

metaR r1662
reactant: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_58d2530c_5c43_4be5_b25a_805bc18da328
constant: false
is: Q13123
type: Species
initial amount: NaN
is: SBO:0000252
name: IK
initial concentration: NaN
is encoded by: hsa:3550
has only substance units: false
boundary condition: true

metaR CHSTEROLtrc
reactant: MODEL1310110002#
type: Reaction
name: transport of cholesterol into the cytosol
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
kinetic law: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000134
reversible: true

metaM gam c
is: HMDB01514
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: C00329
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: CHEBI:17315
name: D-Glucosamine

metaR ADPT
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.7
fast: false
reversible: false
kinetic law: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (353.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.7 Confidence Level: 4 AUTHORS: PMID:14674717,PMID:15196008 NOTES:
reactant: MODEL1310110002#
name: adenine phosphoribosyltransferase
product: MODEL1310110002#
is described by: ECO:0000269

metaM nadp r
is: SBO:0000247
is: HMDB00217
is: CHEBI:58349
boundary condition: false
type: Species
constant: false
is: C00006
initial amount: NaN
name: Nicotinamide adenine dinucleotide phosphate
initial concentration: 1.0
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
has only substance units: false

metaM 3sala m
has only substance units: false
initial amount: NaN
type: Species
name: 3-sulfino-L-alanine (1-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606
constant: false
is: SBO:0000247
is: CHEBI:61085
is: C00606

metaR EX paf hs LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange
type: Reaction

metaR r2368
reversible: true
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110002#
fast: false
type: Reaction
name: Organic anion transporter 5 Utilized transport

metaR r0731
kinetic law: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110002#
fast: false
type: Reaction
name: (S)-Hydroxyoctanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
reversible: false
reactant: MODEL1310110002#

metaM ade c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: C00147
is: SBO:0000247
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
has only substance units: false
type: Species
is: CHEBI:16708
constant: false
name: Adenine
is: HMDB00034

metaR RE3626M
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
modifier: MODEL1310110002#
name: RE3626
fast: false
kinetic law: MODEL1310110002#
reversible: false
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_588e070f_25c6_404a_a90f_b7da708c991b
boundary condition: true
has only substance units: false
name: GGT7
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:2686
is: A0PJJ9
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_0afc3cf2_f862_4026_a5a7_1049288f3391
name: _NOS2A_1_c
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:NOS2A

metaR BILIRUBtr
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reversible: true
kinetic law: MODEL1310110002#
fast: false
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
is: SBO:0000185
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_e2824593_ce28_4846_ac88_99a973eff60c
type: Species
constant: false
initial amount: NaN
is: E5KNH5
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
name: NDUFV1
is encoded by: hsa:4723

metaM accoa x
is: SBO:0000247
has only substance units: false
is: CHEBI:57288
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
is: HMDB01206
boundary condition: false
is: C00024
initial amount: NaN
name: Acetyl-CoA
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_54340954_b8b1_4de7_ac09_fb83f3caffb0
boundary condition: true
constant: false
is: P31350
has only substance units: false
is encoded by: hsa:6241
initial concentration: NaN
initial amount: NaN
type: Species
name: RRM2
is: SBO:0000252

metaR r1656
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110002#
modifier: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM m4masn g
is: SBO:0000247
is: C05881
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C46H77N2O35X CHARGE: 0
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_0698a1ce_eafa_4c80_89dd_786385bcbf19
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: P49902
has only substance units: false
name: NT5C2
is encoded by: hsa:22978
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_069d45ee_95b9_4724_91f4_7256f0e1074b
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:1491
type: Species
initial concentration: NaN
is: P32929
has only substance units: false
name: CTH
constant: false
boundary condition: true

metaR TSTSTERONEtr
is: SBO:0000185
kinetic law: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
fast: false
name: testosterone intracellular transport
type: Reaction
product: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

http://identifiers.org/biomodels.db/MODEL1310110002#_81f98114_b97f_44cb_b209_8ec5e48b21ad
initial amount: NaN
is: B3KTV4
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: ADSSL1
is encoded by: hsa:122622
type: Species
constant: false
boundary condition: true

metaR r2369
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
is: SBO:0000185
reversible: true
product: MODEL1310110002#
fast: false

metaM m7mpdol U r
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
type: Species
initial concentration: 1.0
initial amount: NaN
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:37636

metaR DM dttp m
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: dTTP demand
type: Reaction

metaM 4aphdob c
is: CHEBI:58147
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
boundary condition: false
is: HMDB00978
initial concentration: 1.0
type: Species
has only substance units: false

metaR ACt2m
fast: false
product: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
is: SBO:0000185
name: acetate mitochondrial transport via proton symport

metaM 7dhf e
constant: false
name: heptaglutamyl folate (DHF)
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB06559

metaR CSPG Dtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
name: chondroitin sulfate D transport, extracellular to lysosome
kinetic law: MODEL1310110002#
fast: false

metaR r1655
fast: false
product: MODEL1310110002#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r0730
fast: false
modifier: MODEL1310110002#
reversible: false
is: SBO:0000176
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.211 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.3
name: (S)-Hydroxyoctanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211
is described by: ECO:0000000

metaM leuktrB4 e
has only substance units: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
constant: false
is: SBO:0000247
boundary condition: false
type: Species
is: CHEBI:57461
initial amount: NaN
initial concentration: 1.0
is: HMDB01085
name: leukotriene B4(1-)

metaM fuc L c
is: SBO:0000247
has only substance units: false
is: HMDB00174
initial concentration: 1.0
initial amount: NaN
is: CHEBI:18287
type: Species
name: L-fucose
boundary condition: false
constant: false
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626

metaR r2366
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110002#
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction

metaR r0733
type: Reaction
kinetic law: MODEL1310110002#
fast: false
product: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
reactant: MODEL1310110002#
name: (S)-Hydroxyhexanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
notes: GENE_ASSOCIATION: (8659.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.12
reversible: false
is described by: ECO:0000000

metaR EX dcyt LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxycytidine
type: Reaction

metaM xol7aone c
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
initial amount: NaN
constant: false
is: CHEBI:17899
boundary condition: false
has only substance units: false
name: 7alpha-hydroxycholest-4-en-3-one
is: HMDB01993
initial concentration: 1.0
type: Species
is: SBO:0000247

metaM 4abutn m
initial amount: NaN
constant: false
is: CHEBI:58264
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB01080
name: 4-ammoniobutanal
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_bf599d73_d496_475f_84d9_167811452799
initial concentration: NaN
is: SBO:0000252
is: Q9UIG8
has only substance units: false
name: SLCO3A1
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:28232
constant: false

metaR RE1447M
name: RE1447
notes: GENE_ASSOCIATION: (54995.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
type: Reaction
modifier: MODEL1310110002#
fast: false
product: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.41
reversible: true
is: SBO:0000176

metaR r1654
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185
modifier: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_2ab0df70_4891_4aa0_a9e6_026c9381ee40
name: G6PD
is: P11413
constant: false
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:2539
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_3bd6616e_73de_41d3_9884_ce43cceca34b
is: B3KQ63
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
is encoded by: hsa:3242
name: HPD

metaM cdpdag hs c
name: CDP-diacylglycerol(2-)
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:58332
constant: false
initial concentration: 1.0
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078

metaM dctp c
is: C00458
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB00998
type: Species
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
name: dCTP
initial amount: NaN
constant: false
is: CHEBI:16311
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_6660a9a7_ddba_4d54_bae2_0fe4e93b247c
has only substance units: false
is encoded by: hsa:8639
is: Q16853
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
name: AOC3
initial amount: NaN
boundary condition: true

metaM ksii core2 pre3 g
constant: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58053
is: C00130
is: HMDB00175
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 3
notes: FORMULA: C47H76N4O33X CHARGE: -1

metaR RPE
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/5.1.3.1
notes: GENE_ASSOCIATION: (6120.1) or (6120.2) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 0 AUTHORS: NOTES:SMP
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
fast: false
is: SBO:0000176
product: MODEL1310110002#
name: ribulose 5-phosphate 3-epimerase

metaR LYStm
is described by: ECO:0000269
product: MODEL1310110002#
type: Reaction
name: Lysine mitochondrial transport via ornithine carrier
modifier: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
reactant: MODEL1310110002#
reversible: true
fast: false
kinetic law: MODEL1310110002#

metaR EX galgalgalthcrm hs LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Gal-Gal-Gal-Gal-Gal-Glc-Cer (homo sapiens) exchange
type: Reaction

metaR r2367
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
reversible: true
is: SBO:0000185
product: MODEL1310110002#
name: Organic anion transporter 5 Utilized transport
fast: false

metaR SRTNtu
name: Serotonin uniport
type: Reaction
reactant: MODEL1310110002#
is described by: ECO:0000269
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
product: MODEL1310110002#
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ

http://identifiers.org/biomodels.db/MODEL1310110002#_7c259877_73ac_45d8_b523_2f2941b20b6d
constant: false
initial amount: NaN
initial concentration: NaN
name: AMY1B
boundary condition: true
is: P04745
type: Species
is: SBO:0000252
is encoded by: hsa:277
has only substance units: false

metaR r0732
reactant: MODEL1310110002#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110002#
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
name: Hexanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110002#_4be11a26_1d86_4972_b18f_b216b3f110f4
type: Species
initial concentration: NaN
is: E7EX19
boundary condition: true
is: SBO:0000252
constant: false
name: PIK3R1
has only substance units: false
initial amount: NaN
is encoded by: hsa:5295

metaR ASNtN1
fast: false
name: Asparagine transport (Na, H coupled)
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
type: Reaction
reactant: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
is described by: ECO:0000269
modifier: MODEL1310110002#
is: SBO:0000185

metaR FAOXC160
is: SBO:0000176
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of long chain fatty acid
type: Reaction
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM dutp c
has only substance units: false
is: HMDB01191
constant: false
is: C00460
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial amount: NaN
is: CHEBI:17625
name: dUTP
boundary condition: false

metaR RE1447N
reversible: true
is: SBO:0000176
reactant: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:11756679,PMID:7556092,PMID:7567999,PMID:9295334,PMID:9356448 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110002#
fast: false
name: RE1447

metaR r1653
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_3c4749f0_891e_4f33_8ed5_25354444b3a7
has only substance units: false
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:2882
initial amount: NaN
is: Q96SL4
boundary condition: true
initial concentration: NaN
name: GPX7

metaM h2o g
initial amount: NaN
name: water
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:15377
constant: false
is: HMDB02111
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_11df6e87_a718_4b0b_9b69_4d8c81dab345
is: SBO:0000252
has only substance units: false
constant: false
is: Q9UHI5
initial amount: NaN
name: SLC7A8
type: Species
initial concentration: NaN
is encoded by: hsa:23428
boundary condition: true

metaM nh4 m
is: SBO:0000247
is: HMDB00051
is: CHEBI:28938
initial amount: NaN
is: C01342
type: Species
boundary condition: false
has only substance units: false
name: Ammonium
initial concentration: 1.0
constant: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342

metaR GLCter
kinetic law: MODEL1310110002#
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD
name: glucose transport, endoplasmic reticulum
product: MODEL1310110002#

metaR GDPtg
reactant: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
name: GDP intracellular transport
reversible: true
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_ae13536d_43aa_4685_b39d_bad7e12494a5
type: Species
initial concentration: NaN
initial amount: NaN
name: SLC17A2
is: O00624
is encoded by: hsa:10246
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

metaR MANtly
fast: false
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
is: SBO:0000185
name: mannose efflux from lysosome

metaM leuktrB4 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-9-13-18(21)14-10-7-8-11-15-19(22)16-12-17-20(23)24/h6-11,14-15,18-19,21-22H,2-5,12-13,16-17H2,1H3,(H,23,24)/p-1/b8-7+,9-6-,14-10+,15-11-/t18-,19-/m1/s1 EHMN_ABBREVIATION: C02165
boundary condition: false
is: SBO:0000247
constant: false
name: leukotriene B4(1-)
initial concentration: 1.0
type: Species
is: CHEBI:57461
is: HMDB01085
initial amount: NaN
has only substance units: false

metaR FRUt4
is described by: ECO:0000269
modifier: MODEL1310110002#
name: D-fructose transport via sodium cotransport
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
is: SBO:0000185
reversible: true

metaR ESTRADIOLt
is: SBO:0000185
reversible: true
product: MODEL1310110002#
is described by: ECO:0000000
name: estradiol transport
type: Reaction
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110002#

metaM 10fthf5glu e
initial concentration: 1.0
boundary condition: false
is: CHEBI:57454
initial amount: NaN
constant: false
has only substance units: false
name: 10-formyltetrahydrofolate-[Glu](5)
notes: FORMULA: C40H45N11O19 CHARGE: -6
is: SBO:0000247
is: HMDB00972
type: Species

metaR PIPLC
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
name: phosphatidylinositol phospholipase C
is: SBO:0000176
fast: false
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.1.4.11
reversible: false
product: MODEL1310110002#
is described by: ECO:0000000
type: Reaction

metaR LEUGLYHYc
name: hydrolysis of leucylglycine
type: Reaction
fast: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
is described by: ECO:0000134
is: SBO:0000176
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.

http://identifiers.org/biomodels.db/MODEL1310110002#_2208ce0c_e186_468a_b8e4_a8b29b1a04b8
constant: false
initial concentration: NaN
boundary condition: true
type: Species
name: PCK2
has only substance units: false
is: SBO:0000252
is: Q16822
is encoded by: hsa:5106
initial amount: NaN

metaM ditp c
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
is: SBO:0000247
name: dITP(4-)
has only substance units: false
is: HMDB03537
boundary condition: false
initial concentration: 1.0
type: Species
constant: false
is: CHEBI:61382
initial amount: NaN

metaR r0735
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110002#
name: trans-Dec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
type: Reaction
reversible: true
is: SBO:0000176
product: MODEL1310110002#
fast: false
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
kinetic law: MODEL1310110002#

metaR r2364
product: MODEL1310110002#
fast: false
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
reactant: MODEL1310110002#
type: Reaction
name: Organic anion transporter 5 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110002#_7c8e3f0d_cce2_4482_a73f_c757c18e43b0
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6647
constant: false
is: SBO:0000252
name: SOD1
has only substance units: false
is: P00441
initial amount: NaN

metaR O2St
reversible: true
name: superoxide anion transport via diffusion (extracellular)
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
is described by: ECO:0000000
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_ca172d53_ba5f_4300_af77_bf43babdb46f
name: PIK3CB
type: Species
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5291
is: SBO:0000252
is: B4DER4

metaM glyc3p c
is: SBO:0000247
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
is: HMDB00126
constant: false
is: C00093
initial amount: NaN
name: Glycerol 3-phosphate
has only substance units: false
is: CHEBI:57597
boundary condition: false
type: Species
initial concentration: 1.0

metaM dcsptn1crn m
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
name: docosa-4,7,10,13,16-pentaenoyl carnitine
is: SBO:0000247
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
is: HMDB06321
type: Species
initial concentration: 1.0

metaM ha l
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
is: CHEBI:16336
constant: false
has only substance units: false
name: hyaluronan

metaR DGCHOLtx
product: MODEL1310110002#
type: Reaction
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however bile acids need to be secreted out of the cell NJ
is: SBO:0000185
reactant: MODEL1310110002#
is described by: ECO:0000000
name: bile acid intracellular transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_40149f58_a02d_4279_8299_b931fa17760c
has only substance units: false
type: Species
is encoded by: hsa:3032
initial amount: NaN
is: SBO:0000252
name: HADHB
is: P55084
constant: false
boundary condition: true
initial concentration: NaN

metaM octe5coa m
constant: false
boundary condition: false
name: 5-octenoylcoa
has only substance units: false
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
initial concentration: 1.0
initial amount: NaN
type: Species

metaR EHGLATm
product: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
is: SBO:0000176
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
is described by: ECO:0000212
reversible: false
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.6.1.1
reactant: MODEL1310110002#

metaM lgt S c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
name: (R)-S-lactoylglutathionate(1-)
is: HMDB01066
boundary condition: false
is: CHEBI:57474
notes: FORMULA: C13H20N3O8S CHARGE: -1 INCHI: InChI=1S/C13H21N3O8S/c1-6(17)13(24)25-5-8(11(21)15-4-10(19)20)16-9(18)3-2-7(14)12(22)23/h6-8,17H,2-5,14H2,1H3,(H,15,21)(H,16,18)(H,19,20)(H,22,23)/p-1/t6-,7+,8+/m1/s1
type: Species
has only substance units: false

metaM nadph c
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: HMDB00221
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: SBO:0000247
initial concentration: 1.0
is: C00005

metaR SPMTDe
is: SBO:0000185
kinetic law: MODEL1310110002#
name: SPMTDe
reactant: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
product: MODEL1310110002#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_80d662e1_1aa8_4ae8_b8a0_b26a2205db51
boundary condition: true
initial concentration: NaN
is: P09622
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1738
type: Species
name: DLD

metaM h2o n
is: HMDB02111
is: SBO:0000247
constant: false
boundary condition: false
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
name: water
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001

metaR G14Tg
product: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.38
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
is described by: ECO:0000269
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.1) or (8703.1) or (8704.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:9597550 NOTES:NCD

metaM glutcoa m
is: SBO:0000247
constant: false
name: glutaryl-CoA(5-)
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
is: CHEBI:57378
is: HMDB01339
boundary condition: false
initial concentration: 1.0

metaM anth c
has only substance units: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
is: HMDB01123
boundary condition: false
is: CHEBI:16567
type: Species
name: anthranilate

http://identifiers.org/biomodels.db/MODEL1310110002#_60a1d34a_3ffd_4329_bb9c_bd164626f35c
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:285973
is: Q674R7
name: ATG9B
has only substance units: false
type: Species
boundary condition: true

metaM nadp m
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: C00006
has only substance units: false
is: CHEBI:58349
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate
is: HMDB00217
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_36613904_03b8_45bc_87e5_91053a849503
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:NM 001929
type: Species
has only substance units: false
name: _NM_001929_1_c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_c024da77_633f_406f_ba0c_4e01a7983f0f
constant: false
boundary condition: true
has only substance units: false
name: _AI924226_1_m
is: SBO:0000252
is encoded by: hsa:AI924226
type: Species
initial concentration: NaN
initial amount: NaN

metaM glyclt x
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
name: glycolate
is: CHEBI:29805
initial concentration: 1.0
is: HMDB00115
has only substance units: false
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
constant: false

metaM chsterol e
is: HMDB00067
initial concentration: 1.0
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
name: cholesterol
initial amount: NaN
constant: false
is: CHEBI:16113
is: SBO:0000247
type: Species
boundary condition: false
has only substance units: false

metaR ABO6g
is described by: ECO:0000269
kinetic law: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.37
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
reversible: false
modifier: MODEL1310110002#
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_5a291608_1d4d_4a99_8193_f3209a865470
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:1635
is: P32321
initial concentration: NaN
name: DCTD
initial amount: NaN
constant: false
is: SBO:0000252

metaR r2365
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110002#
name: Organic anion transporter 5 Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110002#
fast: false
type: Reaction
kinetic law: MODEL1310110002#

metaR r0734
reactant: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
name: (S)-Hydroxyhexanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110002#
is described by: ECO:0000000
reversible: false

metaR UGT1A10r
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
fast: false
reactant: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.17
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
is described by: ECO:0000134
product: MODEL1310110002#

metaM lpam m
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C8H15NOS2 CHARGE: 0 INCHI: InChI=1S/C8H15NOS2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00225 EHMN_ABBREVIATION: C00248
is: SBO:0000247
constant: false
type: Species
is: CHEBI:17460
initial amount: NaN
name: lipoamide
is: HMDB00962

metaM prostgh2 e
is: HMDB01381
name: prostaglandin H2(1-)
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57405
type: Species

metaM vitd3 c
type: Species
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28940
initial amount: NaN
has only substance units: false
name: calciol
boundary condition: false
is: HMDB00876
constant: false

metaR EX glcur LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-glucuronate exchange
type: Reaction

metaR ASPDxt
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
is described by: ECO:0000000
product: MODEL1310110002#
type: Reaction
fast: false
is: SBO:0000185
name: D-aspartate transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110002#_44a69488_f154_4714_9cce_6334c0666d7b
is encoded by: hsa:114134
boundary condition: true
initial concentration: NaN
constant: false
name: SLC2A13
is: Q96QE2
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_a7dbf9df_6ebf_4606_9567_3f9571c90348
name: STS
constant: false
is encoded by: hsa:412
has only substance units: false
type: Species
is: P08842
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR DINt
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
type: Reaction
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
name: deoxyinosine transport via diffusion

metaR ACGAMPM
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.4.2.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
product: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
name: phosphoacetylglucosamine mutase
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_3aa557f6_4267_4cbe_b611_7113ac33e48c
name: UPP1
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:7378

metaR r1659
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110002#
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
kinetic law: MODEL1310110002#
is described by: ECO:0000000
fast: false
product: MODEL1310110002#
modifier: MODEL1310110002#

metaM h2o m
is: C00001
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
is: CHEBI:15377
initial concentration: 1.0
is: HMDB02111
has only substance units: false
name: H2O
type: Species
boundary condition: false

metaM adn c
is: SBO:0000247
has only substance units: false
name: Adenosine
type: Species
initial amount: NaN
is: C00212
boundary condition: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial concentration: 1.0
constant: false
is: CHEBI:16335
is: HMDB00050

metaM frdp r
has only substance units: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: CHEBI:175763
name: Farnesyl diphosphate
is: SBO:0000247
initial concentration: 1.0
is: HMDB00961
type: Species
constant: false
boundary condition: false
is: C00448
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_a1a5a2ee_84cc_4ef2_b988_c88588e9ffa0
is: SBO:0000252
has only substance units: false
boundary condition: true
is: O43505
is encoded by: hsa:11041
initial amount: NaN
name: B3GNT1
type: Species
initial concentration: NaN
constant: false

metaR GLYCt
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
product: MODEL1310110002#
name: glycerol transport via channel
is: SBO:0000185
reversible: true

metaM Nacasp m
is: SBO:0000247
is: CHEBI:16953
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
constant: false
boundary condition: false
is: HMDB00812
name: N-acetyl-L-aspartate(2-)
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_809335fc_0951_4853_b83c_3b8afa28e8f3
is encoded by: hsa:51102
is: SBO:0000252
initial concentration: NaN
is: Q9BV79
name: MECR
type: Species
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN

metaR EX spmd LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of spermidine(3+)
type: Reaction

metaR VALPHELAT2tc
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine into the cell and efflux of L-Phenylalanine out of the cell by LAT2 on the basolateral surfaces of kidney and intestine.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_772252c0_9872_416c_b3c5_c2c376a4efe9
constant: false
is encoded by: hsa:33
is: P28330
has only substance units: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: ACADL
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_73ae32ec_f8ee_4e51_a804_f07588508a3d
has only substance units: false
is: SBO:0000252
constant: false
type: Species
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4708
is: H7C5B8
initial amount: NaN
name: NDUFB2

metaR DURAD
is version of: http://identifiers.org/ec-code/1.3.1.2
fast: false
name: dihydrouracil dehydrogenase (NADP)
reversible: true
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
is: SBO:0000176
modifier: MODEL1310110002#

metaR r2362
reactant: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
reversible: true
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_b7113c4b_ec48_48b2_a380_7992cbe6ca8d
is: B8ZZR8
name: GGCT
is encoded by: hsa:79017
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaR LEUKTRE4t
kinetic law: MODEL1310110002#
name: leukotriene E4 transport
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110002#
fast: false
is described by: ECO:0000000
product: MODEL1310110002#
reversible: true

metaR DNDPt8m
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
reversible: false
name: dADP transport via dUDP antiport
kinetic law: MODEL1310110002#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000185

metaR ESTRONEtr
is: SBO:0000185
name: estrone intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
is described by: ECO:0000000
product: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
reactant: MODEL1310110002#

metaM coa x
is: HMDB01423
is: SBO:0000247
constant: false
name: Coenzyme A
boundary condition: false
type: Species
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: C00010
is: CHEBI:57287
has only substance units: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_22299b14_6666_47f7_a112_9803d2cfa1a7
is encoded by: hsa:8402
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
name: SLC25A11
initial amount: NaN
is: F5GY65
constant: false

metaR r1658
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR MM8Cg
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.113
type: Reaction
reversible: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (57134.1) or (10905.1) or (4121.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD

metaM h2o l
has only substance units: false
type: Species
is: CHEBI:15377
notes: FORMULA: H2O CHARGE: 0 INCHI: InChI=1S/H2O/h1H2 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
name: water
initial concentration: 1.0
is: HMDB02111
constant: false
boundary condition: false
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_df356060_c8c5_4088_b73a_25834d93ddfe
is: SBO:0000252
name: RRM1
type: Species
is encoded by: hsa:6240
has only substance units: false
initial amount: NaN
is: P23921
initial concentration: NaN
constant: false
boundary condition: true

metaM chsterol c
is: HMDB00067
is: CHEBI:16113
name: cholesterol
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
constant: false

metaM dece4coa m
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: SBO:0000247
is: HMDB02145
name: 4-decenoylcoa

metaM prostgh2 c
is: HMDB01381
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-19(17)25-24-18)10-7-4-5-8-11-20(22)23/h4,7,12-13,15-19,21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C00427
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57405
name: prostaglandin H2(1-)
is: SBO:0000247
type: Species

metaR APOC LYS BTNPm
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: proteolysis of apoC-Lys-btn, mitochondrial
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction

metaR r2363
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110002#
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
type: Reaction

metaM ksi pre16 g
initial amount: NaN
is: HMDB00175
is: CHEBI:58053
notes: FORMULA: C157H253N11O124S4X CHARGE: -5
name: keratan sulfate I biosynthesis, precursor 16
constant: false
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: C00130
type: Species
has only substance units: false

metaM retn e
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:35291
name: all-trans-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: HMDB01852
has only substance units: false

metaR SERPT
name: serine C-palmitoyltransferase
product: MODEL1310110002#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.50
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
reversible: false
is described by: ECO:0000269

metaR CHOLt4
reactant: MODEL1310110002#
reversible: true
product: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000185
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (60482.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11027560,PMID:11068039,PMID:12675135 NOTES:NCD
fast: false
type: Reaction
name: choline, sodium cotransport
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110002#_657c2bf7_f203_4de7_b873_012497ec896a
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
name: ALDH3B1
is encoded by: hsa:221
constant: false
is: P43353
type: Species
initial concentration: NaN

metaR DM Ser Thr ly
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser/Thr(ly)
type: Reaction

metaM vitd3 e
type: Species
is: SBO:0000247
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
initial concentration: 1.0
initial amount: NaN
is: CHEBI:28940
is: HMDB00876
name: calciol
constant: false
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_fucgalacglcgal14acglcgalgluside_hs_g
name: VI2Fuc-nLc6
type: Species
is: CHEBI:61648
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
initial amount: NaN
initial concentration: 1.0

metaR GLYCTO1p
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.3.15
fast: false
is: SBO:0000176
reactant: MODEL1310110002#
reversible: false
kinetic law: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
name: Glycolate oxidase, peroxisome
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
product: MODEL1310110002#

metaR r1657
fast: false
is: SBO:0000185
product: MODEL1310110002#
reversible: true
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR CORE4GTg
name: Core 4 beta6-GalNAc-transferase, Golgi apparatus
reversible: false
fast: false
product: MODEL1310110002#
is described by: ECO:0000000
modifier: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.102
reactant: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (9245.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.148 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110002#_1a9d9db1_2193_4b8b_b3a2_9d25b393faa7
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: ALDH9A1
initial amount: NaN
is encoded by: hsa:223
constant: false
is: P49189

metaR RE1518M
fast: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.13
product: MODEL1310110002#
is: SBO:0000176
name: RE1518
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110002#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
reactant: MODEL1310110002#

metaM HC02179 c
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: 20-hydroxy-arachidonate
constant: false
is: CHEBI:34306

metaM adn e
name: Adenosine
constant: false
is: HMDB00050
boundary condition: false
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial amount: NaN
type: Species
is: CHEBI:16335
initial concentration: 1.0
is: C00212
has only substance units: false

metaM orot e
constant: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial amount: NaN
initial concentration: 1.0
is: CHEBI:30839
boundary condition: false
name: orotate
is: HMDB00226
has only substance units: false
type: Species
is: SBO:0000247

metaM thf m
is: CHEBI:57453
name: 5,6,7,8-Tetrahydrofolate
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: C00101
boundary condition: false
is: HMDB01846
constant: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
has only substance units: false
type: Species

metaM 3otdcoa m
initial concentration: 1.0
type: Species
is: CHEBI:28726
constant: false
boundary condition: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1S/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h21-22,24,28-30,34,46-47H,4-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/t24-,28-,29-,30+,34-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01400 EHMN_ABBREVIATION: C05261
is: HMDB03935
has only substance units: false
name: 3-Oxotetradecanoyl-CoA
is: SBO:0000247
initial amount: NaN

metaM 4abutn c
is: CHEBI:58264
has only substance units: false
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: HMDB01080
name: 4-Aminobutanal
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species
is: C00555
constant: false

metaM h2o r
is: HMDB02111
has only substance units: false
notes: FORMULA: H2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00011 EHMN_ABBREVIATION: C00001
constant: false
name: H2O
initial amount: NaN
is: CHEBI:15377
is: C00001
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0

metaM hdcea c
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
is: HMDB03229
name: Hexadecenoate (n-C16:1)
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: CHEBI:32372
initial concentration: 1.0
constant: false
type: Species

metaR ALADGLYexR
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
product: MODEL1310110002#
reversible: true
is described by: ECO:0000304
is: SBO:0000185
name: D-alanine/glycine reversible exchange
type: Reaction
fast: false

metaM pnto R e
name: (R)-Pantothenate
is: SBO:0000247
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
boundary condition: false
is: CHEBI:7916
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00210
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_e1ba8210_a941_4163_9de3_0a65e0a2aa37
type: Species
is: Q9Y217
is encoded by: hsa:9107
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: MTMR6
boundary condition: true
constant: false

metaR MI134P4P
reversible: false
fast: false
is: SBO:0000176
product: MODEL1310110002#
name: inositol-1,3,4-trisphosphate 4-phosphatase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
kinetic law: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#

metaM coa m
is: HMDB01423
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
name: Coenzyme A
constant: false
is: CHEBI:57287
has only substance units: false
is: SBO:0000247
is: C00010
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_acglcgalacglcgal14acglcgalgluside_hs_g
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C66H115N4O37FULLRCO CHARGE: 0
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:26174
type: Species
name: (Gal)3 (Glc)1 (GlcNAc)3 (Cer)1
initial amount: NaN

metaR DM taur LPAREN c RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: demand reaction for taurine
type: Reaction

metaR FAOXC122C101m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaR r0013
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110002#
reversible: false
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.52
name: beta-N-acetylhexosaminidase Aminosugars metabolism EC:3.2.1.52
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) SUBSYSTEM: Aminosugar metabolism EC Number: 3.2.1.52 Confidence Level: 0 AUTHORS: PMID:10481922,PMID:2423070,PMID:6219664,PMID:758959 NOTES:

metaM xol7aone m
is: SBO:0000247
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
has only substance units: false
type: Species
initial concentration: 1.0
name: 7alpha-hydroxycholest-4-en-3-one
initial amount: NaN
is: CHEBI:17899
constant: false
boundary condition: false
is: HMDB01993

metaR EX 4nph LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenol exchange
type: Reaction

metaR CYSGLTH
fast: false
is described by: ECO:0000000
product: MODEL1310110002#
name: Glutathione:cystine oxidoreductase
reversible: true
reactant: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.4.4 Confidence Level: 4 AUTHORS: PMID:15189131,PMID:932033 NOTES:reaction according to KEGG MM
kinetic law: MODEL1310110002#
type: Reaction

metaM succ x
has only substance units: false
type: Species
name: Succinate
initial concentration: 1.0
is: C00042
is: HMDB00254
initial amount: NaN
constant: false
notes: FORMULA: C4H4O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00049 EHMN_ABBREVIATION: C00042
boundary condition: false
is: SBO:0000247
is: CHEBI:30031

metaM udp g
is: HMDB00295
is: SBO:0000247
is: CHEBI:58223
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
name: UDP(3-)
constant: false

metaM dutp n
name: dUTP
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial concentration: 1.0
constant: false
is: SBO:0000247
is: CHEBI:17625
is: HMDB01191

http://identifiers.org/biomodels.db/MODEL1310110002#_c388abc2_b370_4561_b88c_f45f092b9e6e
constant: false
is encoded by: hsa:2806
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
name: GOT2
is: P00505
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_b55c8d49_2f13_4507_90df_84c21cd87083
initial concentration: NaN
name: ACSS1
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
type: Species
has only substance units: false
is: Q9NUB1
is encoded by: hsa:84532

metaM Nacasp c
has only substance units: false
is: HMDB00812
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H7NO5 CHARGE: -2 INCHI: InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)/p-2/t4-/m0/s1 EHMN_ABBREVIATION: C01042
name: N-acetyl-L-aspartate(2-)
type: Species
initial amount: NaN
constant: false
is: CHEBI:16953

metaM arachd x
boundary condition: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: CHEBI:32395
constant: false
has only substance units: false
name: arachidonate
initial concentration: 1.0
is: HMDB01043
type: Species
is: SBO:0000247
initial amount: NaN

metaR GLNS
kinetic law: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
name: glutamine synthetase
is version of: http://identifiers.org/ec-code/4.1.1.15
fast: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (2752.1) or (51557.1) SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
is: SBO:0000176
is described by: ECO:0000254
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_34020034_5f8f_492e_b3e8_6966790dd247
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
type: Species
is encoded by: hsa:AI222095
name: _AI222095_1_e

metaM accoa n
is: SBO:0000247
constant: false
has only substance units: false
is: CHEBI:57288
boundary condition: false
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial concentration: 1.0
name: acetyl-CoA(4-)
initial amount: NaN
type: Species

metaM nh4 c
initial concentration: 1.0
name: Ammonium
has only substance units: false
is: CHEBI:28938
type: Species
boundary condition: false
is: SBO:0000247
is: C01342
constant: false
initial amount: NaN
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: HMDB00051

metaM Sfglutth c
initial concentration: 1.0
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
name: S-formylglutathionate(1-)
type: Species
constant: false
is: HMDB01550
is: CHEBI:57688
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false

metaM Lpipecol x
constant: false
initial concentration: 1.0
is: HMDB00716
is: CHEBI:30913
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H11NO2 CHARGE: 0 INCHI: InChI=1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)/t5-/m0/s1 EHMN_ABBREVIATION: C00408
name: L-pipecolic acid
initial amount: NaN
type: Species

metaR HDD2COAtx
fast: false
reversible: true
product: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is: SBO:0000185
type: Reaction
reactant: MODEL1310110002#
name: hdd2coa intracellular transport

metaM fuc L l
is: SBO:0000247
notes: FORMULA: C6H12O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00626
name: L-fucose
initial amount: NaN
initial concentration: 1.0
is: HMDB00174
boundary condition: false
is: CHEBI:18287
has only substance units: false
constant: false
type: Species

metaM retn c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB01852
type: Species
name: all-trans-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:35291

http://identifiers.org/biomodels.db/MODEL1310110002#_b192b60b_268e_4f5b_a9fa_22a77986fc6e
is: Q63HM1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:125061
name: AFMID
initial amount: NaN
type: Species
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_c0704194_3594_4023_a9ef_66289d9860eb
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:953
name: ENTPD1
boundary condition: true
is: Q86VV3
initial concentration: NaN
has only substance units: false

metaM pectindchac e
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C2559H3549O2539 CHARGE: -1
name: pectin-deoxycholic acid complex
is: HMDB03402

http://identifiers.org/biomodels.db/MODEL1310110002#_1ce1d309_b2da_467a_98d3_19b62b943fa0
is encoded by: hsa:4536
type: Species
is: Q7GXY9
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ND2
initial concentration: NaN
constant: false

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaM cs d deg3 l
is: SBO:0000247
constant: false
is: CHEBI:15748
initial amount: NaN
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00127
type: Species
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 3
notes: FORMULA: C37H54NO41S3 CHARGE: -5

metaM coa n
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 INCHI: InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/p-4/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
is: HMDB01423
type: Species
name: coenzyme A(4-)

metaM nadph m
constant: false
is: SBO:0000247
is: HMDB00221
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
boundary condition: false
has only substance units: false
is: C00005
is: CHEBI:57783
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0
initial amount: NaN
type: Species

metaM l2fn2m2masn g
notes: FORMULA: C68H113N4O49X CHARGE: 0
is: CHEBI:28067
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
is: SBO:0000247

metaM dutp m
type: Species
name: dUTP
is: CHEBI:17625
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01191
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
initial concentration: 1.0
has only substance units: false

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

metaM ksi pre25 g
is: SBO:0000247
boundary condition: false
is: C00130
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C199H319N14O163S7X CHARGE: -8
is: HMDB00175
constant: false
name: keratan sulfate I biosynthesis, precursor 25
initial concentration: 1.0
is: CHEBI:58053

metaR PAFt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false
kinetic law: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000
name: 1-alkyl 2-acteylglycerol 3-phosphocholine transport
product: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#

metaM 3dodtricoa m
type: Species
name: 3,6,9-dodecatrienoylcoa
is: C05280
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
has only substance units: false
is: HMDB03952

metaM lald D c
name: (R)-lactaldehyde
is: HMDB06458
has only substance units: false
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
is: CHEBI:17167
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_ff626910_8359_4c9b_a978_eff5d6d63ef0
is: SBO:0000252
initial concentration: NaN
type: Species
name: _100128062_1_m
initial amount: NaN
is encoded by: hsa:100128062
constant: false
boundary condition: true
has only substance units: false

metaM pnto R c
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
is: CHEBI:7916
constant: false
is: HMDB00210
type: Species
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: (R)-Pantothenate
is: SBO:0000247

metaM accoa m
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
has only substance units: false
constant: false
is: C00024
name: Acetyl-CoA
is: HMDB01206
type: Species
initial amount: NaN
is: CHEBI:57288
boundary condition: false
initial concentration: 1.0

metaM btn m
name: biotinate
is: CHEBI:57586
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
is: HMDB00030
has only substance units: false

metaR r2133
is: SBO:0000185
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110002#
reversible: true
product: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110002#
type: Reaction

metaR RE2626C
reversible: true
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
name: RE2626
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110002#_46cd1702_b6bc_4c17_92cc_fbe6bae00f81
initial concentration: NaN
boundary condition: true
has only substance units: false
name: MGLL
is: B2ZGL7
initial amount: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:11343
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_bd1f113a_b533_41ec_88f8_80fd9545bc9a
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: B3GALT5
boundary condition: true
has only substance units: false
is encoded by: hsa:10317
constant: false
type: Species
is: Q9Y2C3

http://identifiers.org/biomodels.db/MODEL1310110002#_b0cdc2b0_ef20_42fc_a27e_c5bb36ea3040
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:171425
boundary condition: true
has only substance units: false
is: Q8N0X4
type: Species
initial amount: NaN
constant: false
name: CLYBL

metaR FAOXC8DCC6DCx
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8DC-->C6DC)x
type: Reaction

metaR GLUPRT
is version of: http://identifiers.org/ec-code/2.4.2.14
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5471.1) SUBSYSTEM: Purine synthesis EC Number: 2.4.2.14 Confidence Level: 4 AUTHORS: PMID:8106516,PMID:8380692,PMID:9108165 NOTES:
modifier: MODEL1310110002#
fast: false
is: SBO:0000176
name: glutamine phosphoribosyldiphosphate amidotransferase
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
reversible: false
product: MODEL1310110002#

metaM nad c
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
is: C00003
has only substance units: false
is: CHEBI:57540
name: Nicotinamide adenine dinucleotide
is: HMDB00902
is: http://identifiers.org/pubchem.compound/3305
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_4bdfddea_c726_47aa_895f_6539e3129a83
type: Species
has only substance units: false
boundary condition: true
name: GSTZ1
is encoded by: hsa:2954
constant: false
is: A6NED0
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaM 6pgc r
name: 6-phosphonatooxy-D-gluconate
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB01316
notes: FORMULA: C6H10O10P CHARGE: -3 INCHI: InChI=1S/C6H13O10P/c7-2(1-16-17(13,14)15)3(8)4(9)5(10)6(11)12/h2-5,7-10H,1H2,(H,11,12)(H2,13,14,15)/p-3/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00292 EHMN_ABBREVIATION: C00345
is: CHEBI:58759
has only substance units: false
type: Species
boundary condition: false
constant: false

metaM nicrns c
is: CHEBI:58527
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: Nicotinate D-ribonucleoside
is: HMDB06809
type: Species
notes: FORMULA: C11H13NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01628 EHMN_ABBREVIATION: C05841

metaM anth e
initial amount: NaN
name: anthranilate
constant: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
is: SBO:0000247
type: Species
is: HMDB01123
is: CHEBI:16567
has only substance units: false
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_952fccb1_5bd7_45de_a9ca_a70e11bbd98b
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is encoded by: hsa:5019
constant: false
is: SBO:0000252
is: P55809
name: OXCT1

metaR SFCYSe
is: SBO:0000185
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000134
name: Exit of sulfocysteine into extra-cellular space
reactant: MODEL1310110002#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES:sulfocysteine is exfreted in urine

metaM etfrd m
type: Species
is: CHEBI:17263
is: HMDB00145
initial amount: NaN
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
name: Electron transfer flavoprotein reduced
notes: FORMULA: RH2 CHARGE: 0
initial concentration: 1.0

metaR SFCYSc
is: SBO:0000176
name: Formation of sulfocysteine
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000134
reactant: MODEL1310110002#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES:non-enzymatic reaction. Sulfocysteine is excreted in the urine.One proton added for elemental balancing.
reversible: true

metaR FADDPle
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/3.1.4.1
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (5167.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: AUTHORS: NOTES:
name: FAD diphosphatase
reversible: false
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
is: SBO:0000176
fast: false
modifier: MODEL1310110002#

metaM 3snpyr m
initial concentration: 1.0
is: CHEBI:1665
name: 3-Sulfinopyruvate
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: HMDB02332
boundary condition: false
notes: FORMULA: C3H2O5S CHARGE: -2 INCHI: InChI=1S/C3H4O5S/c4-2(3(5)6)1-9(7)8/h1H2,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C05527
constant: false

metaR ASNNm
product: MODEL1310110002#
name: L-asparaginase (mitochondrial)
notes: GENE_ASSOCIATION: (80150.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 3.5.1.1 Confidence Level: 2 AUTHORS: PMID:11984834 NOTES:PMID: 11984834 (denotes it as potentially mitochondrial) mm
is version of: http://identifiers.org/ec-code/3.5.1.1
fast: false
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000254
reversible: false
modifier: MODEL1310110002#

metaM C02528 c
type: Species
has only substance units: false
is: SBO:0000247
is: HMDB00518
is: CHEBI:36234
boundary condition: false
name: chenodeoxycholate
constant: false
initial concentration: 1.0
notes: FORMULA: C24H39O4 CHARGE: -1 INCHI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,17-,18+,19+,20-,22+,23+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00958 EHMN_ABBREVIATION: C02528
initial amount: NaN

metaR RE3245C
is: SBO:0000176
reactant: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
name: RE3245
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:IT - fixed proton
type: Reaction
kinetic law: MODEL1310110002#
fast: false

metaM maltpt e
name: maltopentaose
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
has only substance units: false
is: SBO:0000247
is: C02052
type: Species
is: http://identifiers.org/pubchem.compound/5141
is: HMDB01296
constant: false

metaR UMPK4n
is: SBO:0000176
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase (GTP),nuclear
reversible: true
fast: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110002#_219b2c5e_56ff_4535_a6da_60dc59b84d3d
is: Q8IWX5
initial amount: NaN
has only substance units: false
is encoded by: hsa:130367
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
boundary condition: true
name: SGPP2

metaM nh4 e
initial concentration: 1.0
is: CHEBI:28938
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
initial amount: NaN
type: Species
name: ammonium
has only substance units: false
is: SBO:0000247
is: HMDB00051
constant: false

metaR r2132
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
modifier: MODEL1310110002#
is: SBO:0000185
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
fast: false
product: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction

metaR 4HPRO LTte
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
name: Transport of trans-4-hydroxy-L-proline
reactant: MODEL1310110002#
is: SBO:0000185
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000134
reversible: true

metaR GLCNACPT U
reversible: false
name: UDP-GlcNAc:dolichol-phosphate GlcNAc phosphotransferase (uterus)
fast: false
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.8.15
is: SBO:0000176
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1798.1) or (1798.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.7.8.15 Confidence Level: 0 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110002#

metaR XOL7AH2tm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110002#
name: lipid, flip-flop intracellular transport
product: MODEL1310110002#
type: Reaction
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110002#

metaM lthstrl r
is: SBO:0000247
is: HMDB01170
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:17168
name: 5alpha-cholest-7-en-3beta-ol

http://identifiers.org/biomodels.db/MODEL1310110002#_ac5e2a67_212e_4ac3_b61f_b1ed2c3492fd
is encoded by: hsa:4830
is: SBO:0000297
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
name: NME1:NME2

http://identifiers.org/biomodels.db/MODEL1310110002#_cc7765d3_87a7_4078_b1d2_c542227f9f19
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: C9JT23
boundary condition: true
is encoded by: hsa:126328
name: NDUFA11
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_ab1b15bf_6f62_4e13_9da0_6bc7a8c64ff2
name: _BE966236_1_m
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is encoded by: hsa:BE966236

metaR ILETAm
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110002#
kinetic law: MODEL1310110002#
name: isoleucine transaminase, mitochondrial
modifier: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110002#
fast: false

metaR r0840
reversible: true
modifier: MODEL1310110002#
type: Reaction
name: Free diffusion
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.70
notes: GENE_ASSOCIATION: (1595.1) or (83530.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
product: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_c467671c_c60c_4011_953a_20aa84cd5baa
has only substance units: false
name: SLC33A1
initial amount: NaN
is: O00400
is encoded by: hsa:9197
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
constant: false

metaR r1303
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
name: Vesicular transport
type: Reaction
product: MODEL1310110002#
fast: false
is described by: ECO:0000000

metaR VITD3t2
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: false
is described by: ECO:0000000
fast: false
type: Reaction
name: Vitamin D3 uptake
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT
is: SBO:0000185

metaR r2139
modifier: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110002#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
product: MODEL1310110002#
reactant: MODEL1310110002#

metaM xol7aone r
is: HMDB01993
name: 7alpha-hydroxycholest-4-en-3-one
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17899
type: Species
notes: FORMULA: C27H44O2 CHARGE: 0 INCHI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01464 EHMN_ABBREVIATION: C05455
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_d0f89f72_5d63_4040_9942_4398a659313d
is: O00217
type: Species
constant: false
name: NDUFS8
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4728
has only substance units: false

metaM 3hpp m
name: 3-hydroxypropionate
is: SBO:0000247
is: CHEBI:16510
initial concentration: 1.0
initial amount: NaN
is: HMDB00700
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
has only substance units: false
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_ad861a26_2136_405b_9401_877b5fce44ca
boundary condition: true
type: Species
is encoded by: hsa:2645
name: GCK
is: SBO:0000252
initial amount: NaN
is: Q53Y25
has only substance units: false
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_469eb860_3148_4ea2_b58d_0885c46ee811
is: P41222
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5730
initial amount: NaN
has only substance units: false
name: PTGDS

metaR EX csn LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Cytosine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_77086cac_bd59_43db_805d_faa65ce5e879
initial concentration: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:1327
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: P13073
name: COX4I1

metaM lnlccoa c
constant: false
is: HMDB01064
boundary condition: false
is: http://identifiers.org/pubchem.compound/5462164
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,26-28,32-34,38,49-50H,4-7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b9-8+,12-11+
type: Species
name: linoleic coenzyme A

metaM CE2705 n
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
initial concentration: 1.0
is: CHEBI:15374
name: quinonoid dihydrobiopterin
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB02281
is: SBO:0000247
constant: false

metaR PRO Dtde
kinetic law: MODEL1310110002#
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
product: MODEL1310110002#
fast: false
reversible: true
reactant: MODEL1310110002#
name: D-proline transport, extracellular
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.

http://identifiers.org/biomodels.db/MODEL1310110002#_804821e8_771d_4b29_bef4_1216df157295
type: Species
initial concentration: NaN
name: LEFTY1
initial amount: NaN
has only substance units: false
is encoded by: hsa:10637
is: SBO:0000252
is: O75610
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_76935a7e_1a8c_4ccb_aa68_1c0308b66ba3
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:6535
name: SLC6A8
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: B4DIA3
type: Species

metaR BILIRUBt2
name: bilirubin transport via bicarbonate countertransport
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (10599.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:NJ
product: MODEL1310110002#
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110002#
reactant: MODEL1310110002#

metaM csn c
initial concentration: 1.0
name: cytosine
initial amount: NaN
boundary condition: false
is: CHEBI:16040
constant: false
is: HMDB00630
notes: FORMULA: C4H5N3O CHARGE: 0 INCHI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)
is: SBO:0000247
has only substance units: false
type: Species

metaM acgal1p c
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
name: N-Acetyl-D-galactosamine 1-phosphate
boundary condition: false
is: HMDB06480
is: CHEBI:55404
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1

metaR ETFQO
product: MODEL1310110002#
fast: false
reversible: false
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
is version of: http://identifiers.org/ec-code/1.5.5.1
reactant: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
is: SBO:0000176
modifier: MODEL1310110002#

metaM ksi pre32 g
type: Species
is: SBO:0000247
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
has only substance units: false
constant: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 32
is: CHEBI:28067
initial concentration: 1.0
initial amount: NaN

metaR r1396
is: SBO:0000176
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is described by: ECO:0000000
name: EC:2.3.1.21
fast: false
kinetic law: MODEL1310110002#
type: Reaction
reversible: false
product: MODEL1310110002#

metaM HC02203 e
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
has only substance units: false
name: prostaglandin-a2
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:27820

http://identifiers.org/biomodels.db/MODEL1310110002#_e1329d08_92a4_4743_bc2d_938fcc184e05
name: UCK1
is encoded by: hsa:83549
has only substance units: false
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: Q5JT09
boundary condition: true

metaR RDH3
name: retinol dehydrogenase (11-cis,NADH)
reversible: true
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368 NOTES:IT
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.315
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_5adf7b4c_ed54_4029_937a_a512e728757c
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:AF116616
type: Species
has only substance units: false
name: _AF116616_1_m
constant: false
boundary condition: true
initial concentration: NaN

metaM udp c
name: UDP
initial concentration: 1.0
is: HMDB00295
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
type: Species
is: CHEBI:58223
boundary condition: false
constant: false
has only substance units: false
is: C00015
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_24f57bae_0fbf_4465_a70d_949bdcbe6fe4
name: PCBD1
is: P61457
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:5092
initial amount: NaN

metaM 2mpdhl m
name: S-(2-Methylpropanoyl)-dihydrolipoamide
notes: FORMULA: C12H23NO2S2 CHARGE: 0 INCHI: InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) EHMN_ABBREVIATION: C04424
initial amount: NaN
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:17577
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR GLUDxm
modifier: MODEL1310110002#
name: glutamate dehydrogenase (NAD) (mitochondrial)
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reactant: MODEL1310110002#
fast: false
product: MODEL1310110002#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.1.3
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110002#

metaM leuktrA4 c
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: HMDB01337
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
name: leukotriene A4(1-)
constant: false
is: CHEBI:57463
type: Species
initial amount: NaN

metaR EX gal LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Galactose
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_443d4064_bfca_484c_b98d_09338eabc4aa
is: Q6IB80
type: Species
is encoded by: hsa:4709
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: NDUFB3

metaR r0629
reactant: MODEL1310110002#
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
reversible: true
name: Choloyl-CoA:glycine N-choloyltransferase Bile acid biosynthesis / Taurine and hypotaurine metabolism EC:2.3.1.65
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.6.1.22
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI926493.1) or (5167.1) or (5169.1) or (83594.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:10884298,PMID:12239217,PMID:12543708,PMID:15026425,PMID:3741411,PMID:6884990 NOTES:
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.1.4.1
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_de5c5365_ae8d_4e79_84cc_6b1b57726608
is encoded by: hsa:1375
initial concentration: NaN
has only substance units: false
name: CPT1B
type: Species
is: E9PCP2
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252

metaM coa r
boundary condition: false
constant: false
has only substance units: false
is: HMDB01423
initial concentration: 1.0
is: C00010
is: SBO:0000247
notes: FORMULA: C21H32N7O16P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00020 EHMN_ABBREVIATION: C00010
is: CHEBI:57287
type: Species
initial amount: NaN
name: Coenzyme A

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_dfc60143_6581_4cad_96d8_b8862c4fe704
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:2584
boundary condition: true
is: P51570
constant: false
initial amount: NaN
has only substance units: false
name: GALK1
type: Species

metaR EX cspg e LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan exchange
type: Reaction

metaR 3MOPt2im
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
reversible: false
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
is: SBO:0000185
product: MODEL1310110002#
fast: false
type: Reaction

metaR G6PDH2r
is: SBO:0000176
type: Reaction
product: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.49
is described by: ECO:0000000
name: glucose 6-phosphate dehydrogenase
reversible: true
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (2539.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.49 Confidence Level: 0 AUTHORS: NOTES:JLR - a reversible reaction that is otherwise identical to ZWF

http://identifiers.org/biomodels.db/MODEL1310110002#_fb644c41_1569_497f_9533_32245bd74401
is: SBO:0000252
is encoded by: hsa:AI348006
constant: false
has only substance units: false
name: _AI348006_1_c
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR r1397
is described by: ECO:0000000
reversible: false
product: MODEL1310110002#
name: carnitine acetyltransferase EC:2.3.1.7
type: Reaction
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 0 AUTHORS: PMID:12133002,PMID:4475632,PMID:5810070 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110002#

metaM CE4794 m
has only substance units: false
name: cis-6-dodecenoyl-CoA
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:57923
constant: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_a0460d90_11b2_4963_af0e_00bdd1dc08e1
name: SPHK2
type: Species
initial amount: NaN
is: Q9NRA0
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:56848
has only substance units: false

metaM hdcea e
constant: false
is: HMDB03229
type: Species
name: Hexadecenoate (n-C16:1)
is: SBO:0000247
is: CHEBI:32372
has only substance units: false
initial amount: NaN
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
initial concentration: 1.0
boundary condition: false

metaR RDH2
modifier: MODEL1310110002#
name: retinol dehydrogenase (9-cis,NADH)
is described by: ECO:0000269
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.315
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (5959.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:1503811,PMID:7836368,PMID:9115228 NOTES:IT
fast: false
kinetic law: MODEL1310110002#
type: Reaction
is: SBO:0000176
reversible: true

metaR RPI
reversible: true
is version of: http://identifiers.org/ec-code/5.3.1.6
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: NOTES:SMP
name: ribose-5-phosphate isomerase
is: SBO:0000176
modifier: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false

metaR B3GNT32g
modifier: MODEL1310110002#
reversible: false
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reactant: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110002#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110002#_5d815d86_3b5d_419c_bab0_09d918ee4266
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: SLC26A6
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:65010
is: Q9NQU1

http://identifiers.org/biomodels.db/MODEL1310110002#_bcffc38b_93c2_4041_89ca_f187f44f8ef0
is: SBO:0000252
is encoded by: hsa:80025
constant: false
name: PANK2
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

metaM dece3coa m
initial amount: NaN
is: http://identifiers.org/pubchem.compound/16019966
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
name: 3-decenoylcoa
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
constant: false
boundary condition: false

metaR RE0577C
kinetic law: MODEL1310110002#
name: RE0577
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.65
product: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (641372.1) or (641371.1) or (570.1) SUBSYSTEM: Fatty acid synthesis EC Number: 3.1.2.2 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:10578051,PMID:16103133,PMID:16940157,PMID:9153233 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.2.2
reactant: MODEL1310110002#

metaR EX acnacngalgbside hs LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: disialyl galactosylgloboside (homo sapiens) exchange
type: Reaction

metaM cyan c
initial concentration: 1.0
is: HMDB02084
notes: FORMULA: CHN CHARGE: 0 INCHI: InChI=1S/CHN/c1-2/h1H EHMN_ABBREVIATION: C01326
boundary condition: false
initial amount: NaN
has only substance units: false
name: hydrogen cyanide
is: SBO:0000247
constant: false
is: CHEBI:18407
type: Species

metaR AG13T14g
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110002#
reversible: false
modifier: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149

metaM dcsptn1coa x
boundary condition: false
has only substance units: false
constant: false
type: Species
is: HMDB06513
is: http://identifiers.org/pubchem.compound/47205483
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
initial concentration: 1.0
is: SBO:0000247
is: C16173
initial amount: NaN

metaR S6T16g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110002#
fast: false
reversible: false
kinetic law: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110002#

metaM dcsptn1crn c
is: HMDB06321
has only substance units: false
constant: false
initial concentration: 1.0
name: docosa-4,7,10,13,16-pentaenoyl carnitine
is: SBO:0000247
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
boundary condition: false
type: Species
initial amount: NaN

metaR r0842
name: Postulated transport reaction
reactant: MODEL1310110002#
reversible: true
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:7050120 NOTES:
is version of: http://identifiers.org/ec-code/1.3.1.72
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_a735f926_d27e_48d0_b4a6_55b1f0fe14dd
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: PEMT
type: Species
is encoded by: hsa:10400
initial concentration: NaN
has only substance units: false

metaR r0160
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.1.3.2
modifier: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
is: SBO:0000176

metaR r2137
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reactant: MODEL1310110002#
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
is: SBO:0000185
modifier: MODEL1310110002#
type: Reaction
product: MODEL1310110002#

metaM ade e
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
name: adenine
type: Species
has only substance units: false
constant: false
is: HMDB00034
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:16708

metaR RDH1
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
reactant: MODEL1310110002#
reversible: true
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (5959.1) or (8608.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:10329026,PMID:12226107,PMID:12534290,PMID:1503811 NOTES:IT
modifier: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
name: retinol dehydrogenase (all-trans)
is version of: http://identifiers.org/ec-code/1.1.1.315

metaR r1304
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
name: Vesicular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false

metaM adn m
is: HMDB00050
initial amount: NaN
name: adenosine
type: Species
is: CHEBI:16335
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C10H13N5O4 CHARGE: 0 INCHI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212

metaM ditp n
has only substance units: false
is: CHEBI:61382
name: dITP(4-)
is: HMDB03537
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H11N4O13P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O13P3/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)25-6(5)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,22,23)(H,11,12,16)(H2,17,18,19)/p-4/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01345
initial amount: NaN
constant: false
type: Species

metaM frdp x
is: HMDB00961
initial concentration: 1.0
constant: false
is: CHEBI:175763
notes: FORMULA: C15H25O7P2 CHARGE: -3 INCHI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/p-3/b14-9+,15-11+ HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
is: SBO:0000247
boundary condition: false
name: farnesyl pyrophosphate(3-)
initial amount: NaN
type: Species
has only substance units: false

metaR A MANASEly
is described by: ECO:0000000
fast: false
reactant: MODEL1310110002#
type: Reaction
name: alpha-mannosidase, lysosomal
is: SBO:0000176
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (4125.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.24 Confidence Level: 0 AUTHORS: PMID:8910458 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.24
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110002#_776f6885_b0d3_474a_97e6_41cfc90e6fb8
initial amount: NaN
is: SBO:0000252
is: P43353
is encoded by: hsa:221
constant: false
initial concentration: NaN
has only substance units: false
name: ALDH3B1
boundary condition: true
type: Species

metaM nadp c
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB00217
is: C00006
notes: FORMULA: C21H25N7O17P3 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00016 EHMN_ABBREVIATION: C00006
is: CHEBI:58349
boundary condition: false
name: Nicotinamide adenine dinucleotide phosphate

http://identifiers.org/biomodels.db/MODEL1310110002#_476e3b95_3a4d_44ab_8955_8a7e14269db9
initial amount: NaN
is encoded by: hsa:4125
is: SBO:0000252
boundary condition: true
name: MAN2B1
constant: false
initial concentration: NaN
is: O00754
has only substance units: false
type: Species

metaR MDHx
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: Confidence Level: 2 AUTHORS: PMID: 17173541 NOTES:added during gap filling. Assumption that such a reaction can exist. Mamalian peroxisome do not contain malate dehydrogenase.
is described by: ECO:0000134
fast: false
name: malate dehydrogenase, peroxisomal
reversible: true
is: SBO:0000176

metaM oxa x
initial concentration: 1.0
is: CHEBI:30623
initial amount: NaN
is: SBO:0000247
boundary condition: false
type: Species
name: oxalate(2-)
has only substance units: false
is: HMDB02329
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_424ae5c4_049f_41ed_8cd3_43083c23a7cc
initial concentration: NaN
type: Species
is encoded by: hsa:29880
has only substance units: false
initial amount: NaN
constant: false
is: Q9Y673
is: SBO:0000252
name: ALG5
boundary condition: true

metaM 20ahchsterol m
initial amount: NaN
initial concentration: 1.0
is: HMDB06283
is: CHEBI:1296
name: 20-hydroxycholesterol
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
has only substance units: false
constant: false
is: SBO:0000247
type: Species

metaM hexdiac c
initial concentration: 1.0
name: hexadecanediocacid
constant: false
is: C08260
notes: FORMULA: C16H28O4 CHARGE: -2
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00672

metaM leuktrA4 e
type: Species
is: CHEBI:57463
boundary condition: false
is: SBO:0000247
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial concentration: 1.0
initial amount: NaN
name: leukotriene A4(1-)
is: HMDB01337
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_464d3e39_9edc_49b6_bfe0_faa1030ab920
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
name: GALNT3
is: Q14435
is encoded by: hsa:2591
initial amount: NaN
constant: false

metaR URIK1
is: SBO:0000176
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.1.48
reversible: false
fast: false
reactant: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
name: uridine kinase (ATP:Uridine)
is described by: ECO:0000269

metaR r0841
reactant: MODEL1310110002#
type: Reaction
fast: false
kinetic law: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (7264.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16756494 NOTES:
reversible: true
modifier: MODEL1310110002#
name: Free diffusion
is version of: http://identifiers.org/ec-code/1.1.1.271
is described by: ECO:0000000

metaR C204CRNt
kinetic law: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV C20:4 transport
is: SBO:0000185
name: arachidonic acid transport into the mitochondria
reactant: MODEL1310110002#
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_146831a9_4c13_48ee_83b3_d7b25189ee44
name: CA3
has only substance units: false
is: P07451
is encoded by: hsa:761
constant: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

metaR r2136
is: SBO:0000185
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
reversible: false
reactant: MODEL1310110002#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
fast: false
product: MODEL1310110002#

metaR GMPtg
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
reversible: true
name: GMP transport (Golgi)
type: Reaction
is: SBO:0000185
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110002#_78c2879e_80c7_4a1a_93d0_4514199d7970
has only substance units: false
is: P45954
is encoded by: hsa:36
constant: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN
name: ACADSB

http://identifiers.org/biomodels.db/MODEL1310110002#_3333ed97_1ee8_4b65_a662_7c2cf51eb915
is: Q12882
name: DPYD
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1806
constant: false

metaR CITtbm
product: MODEL1310110002#
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: citrate transport, mitochondrial
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
reversible: true

metaR FAOXC101C8m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_metaR_EX_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_LPAREN_e_RPAREN_
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_19e35d22_37a6_4d40_a4af_a19bc182556e
initial concentration: NaN
is encoded by: hsa:3032
initial amount: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: P55084
boundary condition: true
name: HADHB
type: Species

metaM HC00229 e
is: CHEBI:28189
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
name: Isomaltose
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR G14T18g
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
type: Reaction
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is: SBO:0000176
modifier: MODEL1310110002#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110002#
reversible: false
is described by: ECO:0000000

metaM HC02203 c
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
name: prostaglandin-a2
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C05953
initial amount: NaN
is: CHEBI:27820
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_b46b5071_1751_460b_bc61_c8e52953784c
initial concentration: NaN
is: P23786
type: Species
has only substance units: false
constant: false
boundary condition: true
name: CPT2
initial amount: NaN
is encoded by: hsa:1376
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_270978e4_13f9_4321_aa1a_e660d9075a08
initial amount: NaN
is: P27987
is encoded by: hsa:3707
is: SBO:0000252
name: ITPKB
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
type: Species

metaR biomass reaction
is: SBO:0000185
is described by: ECO:0000134
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
reversible: false
product: MODEL1310110002#
fast: false
type: Reaction
kinetic law: MODEL1310110002#
name: biomass_reaction

metaR SADT
reversible: false
reactant: MODEL1310110002#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
name: sulfate adenylyltransferase
is version of: http://identifiers.org/ec-code/2.7.1.25
modifier: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_fbd880d0_ce19_4f66_9321_b90db0754e8a
boundary condition: true
is encoded by: hsa:145226
constant: false
is: SBO:0000252
name: RDH12
type: Species
initial amount: NaN
initial concentration: NaN
is: Q96NR8
has only substance units: false

metaM gluside hs g
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false
name: D-glucosyl-N-acylsphingosine
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:18368

metaR XOL27OHtm
is: SBO:0000185
product: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
type: Reaction
fast: false
is described by: ECO:0000000
name: 27 hydroxy cholesterol transport
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ

metaM 2dr1p c
has only substance units: false
name: 2-Deoxy-D-ribose 1-phosphate
boundary condition: false
is: HMDB01351
constant: false
type: Species
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
is: C00672
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58576
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_e3f21ba5_f01f_44b1_8484_9593e59bec12
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2348
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: FOLR1

metaM fprica c
boundary condition: false
initial amount: NaN
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB01439
constant: false
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
is: C04734
is: CHEBI:58467
is: SBO:0000247

metaM arg L e
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
initial amount: NaN
type: Species
is: CHEBI:32682
initial concentration: 1.0
is: HMDB00517
constant: false
boundary condition: false
has only substance units: false
name: L-argininium(1+)
is: SBO:0000247

metaR KSII CORE4t
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
name: keratan sulfate II (core4) transport, golgi to extracellular
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
fast: false

metaR S6T14g
reversible: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110002#
fast: false
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176

metaR r0616
product: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (C7orf24.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
kinetic law: MODEL1310110002#
fast: false
type: Reaction
name: trans-4-Hydroxy-L-proline:NAD+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
reactant: MODEL1310110002#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110002#_f787c536_08de_4e82_997b_8b3e877c6e9d
constant: false
is encoded by: hsa:2582
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: GALE
is: Q38G75
is: SBO:0000252
type: Species

metaM fuc12gal14acglcgalgluside hs g
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C50H89N2O26FULLRCO CHARGE: 0
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00304
constant: false
name: Type IIH glycolipid
is: CHEBI:57847

http://identifiers.org/biomodels.db/MODEL1310110002#_686d48bd_8dee_4618_b317_3891e776f21d
initial concentration: NaN
name: ABP1
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:26
type: Species
boundary condition: true
is: P19801

metaR CHOLD2m
reversible: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (55349.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.99.1 Confidence Level: 4 AUTHORS: PMID:15321791 NOTES:
reactant: MODEL1310110002#
type: Reaction
is: SBO:0000176
name: choline dehydrogenase (FAD acceptor), mitochondrial
is version of: http://identifiers.org/ec-code/1.1.99.1
kinetic law: MODEL1310110002#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_2c9338e6_e6d6_45c3_b561_07fda016456a
type: Species
has only substance units: false
is encoded by: hsa:766
initial amount: NaN
is: Q86YU0
is: SBO:0000252
name: CA7
boundary condition: true
initial concentration: NaN
constant: false

metaM ficytC m
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00123
is: SBO:0000247
is: CHEBI:15991
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
name: Ferricytochrome c

metaM HC01406 m
initial concentration: 1.0
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267
name: 3-Oxooctanoyl-CoA
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:28264
type: Species

metaR PSt3
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
name: phosphatidylserine transport
reversible: true
is described by: ECO:0000269
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_galacglcgal14acglcgalgluside_hs_g
type: Species
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:26174
name: i-antigen
notes: FORMULA: C58H102N3O32FULLRCO CHARGE: 0

metaM itp c
is: HMDB00189
type: Species
boundary condition: false
is: CHEBI:57614
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial concentration: 1.0
is: SBO:0000247
constant: false
name: ITP(3-)

http://identifiers.org/biomodels.db/MODEL1310110002#_dc19b554_ef4a_4f7b_a00b_cdbe547b66f2
initial amount: NaN
name: _NOS2A_1_e
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true
is encoded by: hsa:NOS2A
constant: false

metaR r0839
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:7419607 NOTES:
is described by: ECO:0000000
product: MODEL1310110002#
type: Reaction
is: SBO:0000185
reversible: true
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.1.70
fast: false
name: Postulated transport reaction

metaM g6p r
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: C00092
is: CHEBI:61548
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
is: HMDB01401
initial amount: NaN
constant: false
has only substance units: false
name: D-Glucose 6-phosphate

metaR CYSSNAT5tc
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of L-Cysteine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_d8ca2131_4950_4348_8369_5c21790fd153
name: DHODH
initial amount: NaN
has only substance units: false
is: SBO:0000252
is: Q02127
constant: false
initial concentration: NaN
is encoded by: hsa:1723
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_0b39c813_501b_49cd_90b2_2359078bd43f
initial concentration: NaN
type: Species
is encoded by: hsa:113026
initial amount: NaN
is: Q8N3E9
is: SBO:0000252
constant: false
boundary condition: true
name: PLCD3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_138cab90_5edc_4eae_9a5d_2b3d66e30e69
name: DGKD
has only substance units: false
boundary condition: true
is: Q16760
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:8527
initial concentration: NaN

metaM CE2424 m
is: CHEBI:28387
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
constant: false
is: HMDB11123
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_e5d74d37_be8f_4202_9b2a_3efb03f106a4
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AA576959
boundary condition: true
name: _AA576959_1_c
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_95278f4c_7586_4cd9_b896_f854bb3f7c4c
is encoded by: hsa:3251
name: HPRT1
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is: P00492
initial concentration: NaN

metaR BTNt2
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110002#
fast: false
is: SBO:0000185
name: Biotin reversible transport via proton symport
type: Reaction
reversible: true
reactant: MODEL1310110002#
product: MODEL1310110002#

metaR EX dchac LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for deoxycholic acid
type: Reaction

metaM pep m
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
has only substance units: false
boundary condition: false
type: Species
is: HMDB00263
is: C00074
name: Phosphoenolpyruvate
is: CHEBI:18021
initial concentration: 1.0

metaR S23T4g
name: beta-galactoside alpha-2,3-sialyltransferase
modifier: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
product: MODEL1310110002#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6484.1) or (6482.1) or (6483.1) or (6482.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:7901202,PMID:8027041,PMID:8288606,PMID:8920913 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.99.4
fast: false
is: SBO:0000176
kinetic law: MODEL1310110002#

metaR FAOXC164C143m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaR NDPK5n
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
product: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110002#
type: Reaction
reversible: true

metaR RE2974C
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.68
is version of: http://identifiers.org/ec-code/2.7.1.149
kinetic law: MODEL1310110002#
product: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (8395.1) or (23396.1) or (5305.1) or (8396.1) or (79837.1) or (8394.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 0 AUTHORS: PMID:10231032,PMID:10358929,PMID:11493657,PMID:9211928 NOTES:
reactant: MODEL1310110002#
name: RE2974

http://identifiers.org/biomodels.db/MODEL1310110002#_788f0d5b_170c_4c34_ad68_1dbee3d84aef
is encoded by: hsa:728441
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
name: GGT2
initial amount: NaN
type: Species
initial concentration: NaN

metaM oxa m
boundary condition: false
initial concentration: 1.0
is: CHEBI:30623
is: SBO:0000247
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
type: Species
name: oxalate(2-)
initial amount: NaN
constant: false
has only substance units: false
is: HMDB02329

metaR CSDPASEly
name: chondroitin sulfate D proteoglycan protease, lysosome (endosome)
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
reversible: false
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110002#
fast: false
is described by: ECO:0000000
product: MODEL1310110002#
reactant: MODEL1310110002#

metaM thf e
name: (6S)-5,6,7,8-tetrahydrofolate(2-)
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:57453
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB01846
notes: FORMULA: C19H21N7O6 CHARGE: -2 INCHI: InChI=1S/C19H23N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,11-12,21,23H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101

http://identifiers.org/biomodels.db/MODEL1310110002#_8f61bf10_6733_4fba_b2bb_6a0e4d457bbd
has only substance units: false
is encoded by: hsa:9583
initial concentration: NaN
boundary condition: true
constant: false
type: Species
initial amount: NaN
is: Q9Y227
is: SBO:0000252
name: ENTPD4

metaM apoC Lys btn m
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
is: HMDB03134
initial amount: NaN
boundary condition: false
type: Species
is: http://identifiers.org/pubchem.compound/7886
initial concentration: 1.0
has only substance units: false
constant: false
is: C05552
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: SBO:0000247

metaM 7dhchsterol c
is: HMDB00032
has only substance units: false
boundary condition: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00693 EHMN_ABBREVIATION: C01164
name: cholesta-5,7-dien-3beta-ol
is: CHEBI:17759
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: SBO:0000247

metaR r0614
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: 4.1.1.36 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:13630913,PMID:15893380,PMID:4459135,PMID:6061681 NOTES:
name: N-[(R)-4-Phosphopantothenoyl]-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.36
kinetic law: MODEL1310110002#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110002#
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_60da3bbb_6a6f_461c_a20e_811f8a2ee338
has only substance units: false
boundary condition: true
is encoded by: hsa:3945
is: SBO:0000252
type: Species
is: P07195
initial concentration: NaN
initial amount: NaN
name: LDHB
constant: false

metaR RE1254C
fast: false
is described by: ECO:0000000
product: MODEL1310110002#
reversible: true
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
is: SBO:0000176
name: RE1254

metaM adp e
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB01341
type: Species
is: CHEBI:456216
boundary condition: false
name: ADP(3-)
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008

metaM accoa g
initial concentration: 1.0
type: Species
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: CHEBI:57288
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: acetyl-CoA(4-)
is: HMDB01206

http://identifiers.org/biomodels.db/MODEL1310110002#_39f46c90_b7f3_485a_9ecf_6166a28e9c2d
constant: false
name: HSD3B2
is encoded by: hsa:3284
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
is: P26439
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_314db3ee_c424_4878_ae88_2efcb57c3dde
is encoded by: hsa:9123
has only substance units: false
initial concentration: NaN
constant: false
name: SLC16A3
type: Species
is: SBO:0000252
is: O15427
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_15c5bca4_0eb9_4078_be5a_83addd9c990b
is encoded by: hsa:728441
name: GGT2
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true

metaR 3SALATAim
fast: false
is: SBO:0000176
reversible: false
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000304
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
type: Reaction
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
reactant: MODEL1310110002#
product: MODEL1310110002#

metaR TALA
reversible: true
fast: false
reactant: MODEL1310110002#
name: transaldolase
is version of: http://identifiers.org/ec-code/2.2.1.2
type: Reaction
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
product: MODEL1310110002#
is: SBO:0000176

metaR r1733
reactant: MODEL1310110002#
reversible: false
kinetic law: MODEL1310110002#
is: SBO:0000185
fast: false
modifier: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110002#
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110002#_86a36b05_5390_48f0_ac74_4a3dc6880b74
is: Q9UBM7
is encoded by: hsa:1717
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
name: DHCR7

http://identifiers.org/biomodels.db/MODEL1310110002#_b8fd73a1_6317_4428_9fcb_d1b92e272a68
name: HKDC1
constant: false
is: SBO:0000252
is: B3KT70
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:80201
initial concentration: NaN
has only substance units: false

metaM lys L x
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: SBO:0000247
type: Species
initial amount: NaN
name: L-lysinium(1+)
is: CHEBI:32551
is: HMDB00182
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false

metaR r2140
modifier: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is described by: ECO:0000000

metaR O2tp
is: SBO:0000185
kinetic law: MODEL1310110002#
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
name: O2 transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

metaR r0944
name: Active transport
fast: false
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:1526979 NOTES:
product: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110002#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_76bc852b_3024_474d_894e_f0f1ff392c64
has only substance units: false
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: MTHFD1L
constant: false
initial concentration: NaN
is: B2RD24
is encoded by: hsa:25902

metaM HC02121 c
initial amount: NaN
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
is: SBO:0000247
name: S-(hydroxymethyl)glutathione(1-)
is: CHEBI:58758
constant: false
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0

metaR r0423
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is described by: ECO:0000000
modifier: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
is: SBO:0000176

metaR NACASPtm
is: SBO:0000185
fast: false
type: Reaction
name: N-acetyl-L-aspartate transport (mitochondria to cytosol)
reversible: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11279290 NOTES:MM
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_a0d17d99_a311_4aca_917b_7042601da541
is encoded by: hsa:9334
initial amount: NaN
is: O43286
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
name: B4GALT5

metaM dcamp c
constant: false
is: C03794
boundary condition: false
is: SBO:0000247
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
initial amount: NaN
name: N6-(1,2-Dicarboxyethyl)-AMP
type: Species
is: CHEBI:57567
has only substance units: false
is: HMDB00536
initial concentration: 1.0

metaR LEUKTRD4t
is: SBO:0000185
fast: false
kinetic law: MODEL1310110002#
name: leukotriene D4 transport
is described by: ECO:0000269
reversible: true
product: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10358072,PMID:12507753,PMID:9334206 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_2dde7794_a42d_4059_aa53_dce0d4b600e2
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: OXSM
is encoded by: hsa:54995
boundary condition: true
type: Species
is: Q9NWU1
is: SBO:0000252
constant: false

metaM leuktrC4 c
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
name: leukotriene C4(2-)
is: HMDB01198
is: CHEBI:57973
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_3e75836e_9d3d_4615_8b85_c4946053a737
is: P41247
name: PNPLA4
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:8228
initial amount: NaN
boundary condition: true
initial concentration: NaN

metaR G14T10g
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
reactant: MODEL1310110002#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
modifier: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
fast: false

metaM xol27oh r
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: 26-hydroxycholesterol
is: HMDB02103
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17703
type: Species

metaM sucsal m
name: Succinic semialdehyde
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
is: HMDB01259
boundary condition: false
is: CHEBI:57706
initial amount: NaN
has only substance units: false

metaR r0210
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: 4.2.1.22 Confidence Level: 0 AUTHORS: PMID:681363 NOTES:
reactant: MODEL1310110002#
is: SBO:0000176
name: L-Serine hydro-lyase (adding homocysteine) Glycine, serine and threonine metabolism EC:4.2.1.22
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
reversible: false

metaR GLXO2p
reversible: false
modifier: MODEL1310110002#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110002#
name: glyoxylate oxidase, peroxisomal
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.3.15
is: SBO:0000176
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (54363.1) or (51179.2) or (51179.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.3.15 Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:NCD
fast: false

metaR r2141
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110002#
is: SBO:0000185

metaR r0838
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
name: Free diffusion
is version of: http://identifiers.org/ec-code/3.1.2.4
is: SBO:0000185
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:3888072 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_4780093c_0aff_4ce6_b21e_0f78b5d880f5
is: P49448
boundary condition: true
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
name: GLUD2
has only substance units: false
is encoded by: hsa:2747
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_ae0facb4_fec9_4ef7_904f_000f2e3d2855
name: PPAT
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:5471
initial concentration: NaN
is: Q06203
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_6ebd4f6d_a933_4354_9300_fef22aaaa3dd
is encoded by: hsa:83530
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
name: _83530_1_c
constant: false
initial concentration: NaN

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR SERtN1
type: Reaction
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
name: Serine transport (Na, H coupled)
reactant: MODEL1310110002#
reversible: true
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92745.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12845534 NOTES:SAB based on PMID 12845534
product: MODEL1310110002#

metaM o2 n
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 INCHI: InChI=1S/O2/c1-2 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
type: Species
is: HMDB01377
name: dioxygen
boundary condition: false
is: CHEBI:15379
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_11ef08a7_01d8_46b5_815d_127cd992fbae
constant: false
type: Species
is encoded by: hsa:W74642
initial concentration: NaN
initial amount: NaN
name: _W74642_1_c
is: SBO:0000252
boundary condition: true
has only substance units: false

metaR r2142
type: Reaction
product: MODEL1310110002#
is: SBO:0000185
modifier: MODEL1310110002#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110002#
fast: false

metaR S2TASE5ly
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.18 Confidence Level: 4 AUTHORS: PMID:2497731,PMID:4019466,PMID:8993162 NOTES:NCD
is: SBO:0000176
reversible: false
name: glucuronate-2-sulfatase, lysosomal
fast: false
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_a349c34e_f3ab_410f_aee3_96ed612ea5a8
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
name: _AI222095_1_m
initial concentration: NaN
constant: false
is encoded by: hsa:AI222095
initial amount: NaN

metaM o2 r
is: C00007
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
constant: false
has only substance units: false
is: SBO:0000247
name: O2
is: HMDB01377
is: CHEBI:15379

metaR r0224
kinetic law: MODEL1310110002#
name: 5,6,7,8-Tetrahydrofolate:NAD+ oxidoreductase One carbon pool by folate EC:1.5.1.3
reactant: MODEL1310110002#
product: MODEL1310110002#
reversible: false
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 0 AUTHORS: PMID:15153070,PMID:1631094,PMID:6882460 NOTES:
modifier: MODEL1310110002#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_649b02e9_df4f_4580_a18a_7e9e2e7dc0e6
is: O75106
initial amount: NaN
is encoded by: hsa:314
constant: false
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
name: AOC2

metaM nadph r
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
is: CHEBI:57783
initial amount: NaN
is: SBO:0000247
is: C00005
name: Nicotinamide adenine dinucleotide phosphate - reduced
boundary condition: false
is: HMDB00221

metaR TYRt
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
type: Reaction
fast: false
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110002#
name: L-tyrosine transport
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
product: MODEL1310110002#

metaR r0946
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110002#

metaM oaa x
is: HMDB00223
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
has only substance units: false
name: Oxaloacetate
constant: false
type: Species
is: C00036
boundary condition: false
initial amount: NaN
is: CHEBI:16452
initial concentration: 1.0
is: SBO:0000247

metaR RE3050R
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215 NOTES:
reactant: MODEL1310110002#
fast: false
is described by: ECO:0000000
product: MODEL1310110002#
reversible: true
name: RE3050
is: SBO:0000176

metaR ACACt2
product: MODEL1310110002#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110002#
reversible: true
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
name: acetoacetate transport via proton symport
fast: false
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:originally named AACTP NCD
is described by: ECO:0000269

metaR r0425
kinetic law: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.1.4
name: EC:1.1.1.42
modifier: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:18484410,PMID:9866202 NOTES:
reactant: MODEL1310110002#
is: SBO:0000176
product: MODEL1310110002#
reversible: true
is described by: ECO:0000000

metaR LYSt4
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (11254.1) or (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11133652,PMID:12719981 NOTES:SAB
reactant: MODEL1310110002#
type: Reaction
is described by: ECO:0000304
reversible: false
product: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000185
name: L-lysine transport in via sodium symport

metaR C14STRr
type: Reaction
reversible: false
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.1.70
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
is: SBO:0000176
product: MODEL1310110002#
name: C-14 sterol reductase
fast: false
is described by: ECO:0000134
modifier: MODEL1310110002#

metaM leuktrC4 e
has only substance units: false
type: Species
is: HMDB01198
initial concentration: 1.0
boundary condition: false
is: CHEBI:57973
is: SBO:0000247
name: leukotriene C4(2-)
initial amount: NaN
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
constant: false

metaR RE3524R
fast: false
name: RE3524
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
reversible: true
is described by: ECO:0000000

metaM 56dura c
initial concentration: 1.0
has only substance units: false
boundary condition: false
name: 5,6-dihydrouracil
constant: false
is: CHEBI:15901
is: SBO:0000247
is: HMDB00076
type: Species
initial amount: NaN
notes: FORMULA: C4H6N2O2 CHARGE: 0 INCHI: InChI=1S/C4H6N2O2/c7-3-1-2-5-4(8)6-3/h1-2H2,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00348 EHMN_ABBREVIATION: C00429

metaR r0591
is version of: http://identifiers.org/ec-code/1.2.1.5
reactant: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
type: Reaction
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
modifier: MODEL1310110002#
reversible: true
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
product: MODEL1310110002#

metaR ANTHte
fast: false
reversible: true
reactant: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
name: Transport of anthranilate
is described by: ECO:0000134

metaM arg L c
is: CHEBI:32682
type: Species
initial concentration: 1.0
constant: false
initial amount: NaN
is: SBO:0000247
name: L-argininium(1+)
boundary condition: false
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
has only substance units: false
is: HMDB00517

metaM mercplaccys e
name: 3-mercaptolactate-cysteine disulfide
has only substance units: false
boundary condition: false
constant: false
initial concentration: 1.0
is: HMDB06512
initial amount: NaN
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
is: SBO:0000247
type: Species

metaR r0836
modifier: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.5.4.16
type: Reaction
reactant: MODEL1310110002#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
product: MODEL1310110002#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_20f20638_2493_43dc_8ee0_5db134d1c5c5
constant: false
initial amount: NaN
name: DGKB
boundary condition: true
has only substance units: false
initial concentration: NaN
is: Q9Y6T7
is: SBO:0000252
is encoded by: hsa:1607
type: Species

metaR PVD3
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:6281884 NOTES:This reaction takes place in skin and needs UV 290-305. based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
reversible: true
is described by: ECO:0000134
type: Reaction
is: SBO:0000176
name: Previtamin D3 formation
product: MODEL1310110002#

metaR EX chtn LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chitin exchange
type: Reaction

metaM pram c
is: C03090
is: SBO:0000247
boundary condition: false
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
constant: false
is: CHEBI:58681
name: 5-Phospho-beta-D-ribosylamine
has only substance units: false
initial amount: NaN
is: HMDB01128
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_5a0f19da_0d67_458f_95bb_889eec0571c3
initial concentration: NaN
has only substance units: false
is: Q92819
constant: false
is encoded by: hsa:3037
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: HAS2
type: Species

metaR r0590
is: SBO:0000176
modifier: MODEL1310110002#
reversible: false
type: Reaction
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reactant: MODEL1310110002#
product: MODEL1310110002#

metaM udpg r
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
name: [(2R,3S,4R,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl {[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl phosphonato]oxy}phosphonate
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB00286
is: CHEBI:58367
type: Species
constant: false
initial amount: NaN
boundary condition: false

W3 CDTF: Fri Aug 31 01:35:30 BST 2012

metaR r0426
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.5.1.34
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
reversible: true
is described by: ECO:0000000
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_3f278fb8_62f7_4193_aa91_23bd219df915
type: Species
has only substance units: false
is: SBO:0000252
boundary condition: true
is: Q8IZV5
constant: false
name: RDH10
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:157506

http://identifiers.org/biomodels.db/MODEL1310110002#_1659dee7_62c4_4f9c_aa0f_90da2a9375c4
name: ALDH3B2
initial amount: NaN
is encoded by: hsa:222
constant: false
is: SBO:0000252
is: P48448
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false

metaM cs e deg4 l
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 4
has only substance units: false
type: Species
notes: FORMULA: C31H46NO38S4 CHARGE: -5
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:15748
initial concentration: 1.0
is: HMDB00127

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaM C02470 c
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
name: Xanthurenic acid
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/5485
boundary condition: false
is: HMDB00881
is: C02470
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_acbc9069_d6e5_4650_b678_c11e5785d0ab
is: SBO:0000252
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:389015
has only substance units: false
boundary condition: true
initial concentration: NaN
name: SLC9A4
is: Q6AI14

metaM glyc m
is: C00116
constant: false
is: CHEBI:17754
type: Species
initial concentration: 1.0
is: SBO:0000247
name: Glycerol
is: HMDB00131
initial amount: NaN
has only substance units: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
boundary condition: false

metaM arg L m
notes: FORMULA: C6H15N4O2 CHARGE: 1 INCHI: InChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00065
is: HMDB00517
initial amount: NaN
name: L-argininium(1+)
is: CHEBI:32682
type: Species
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

metaM cs c l
is: CHEBI:16347
is: HMDB00062
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
type: Species
boundary condition: false
is: SBO:0000247
constant: false
is: C00318
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: chondroitin sulfate C (GalNAc6S-GlcA), free chain

metaM oxa c
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
has only substance units: false
constant: false
initial amount: NaN
name: oxalate(2-)
is: HMDB02329
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
is: CHEBI:30623

metaR DURIt
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
reversible: true
reactant: MODEL1310110002#
type: Reaction
name: deoxyuridine transport via diffusion
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_2e51e7dd_1c2a_4da8_afac_ce0969536302
initial amount: NaN
type: Species
constant: false
is: SBO:0000252
name: AK2
initial concentration: NaN
is encoded by: hsa:204
has only substance units: false
is: P54819
boundary condition: true

metaR PCHOLPm hs
modifier: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
is version of: http://identifiers.org/ec-code/3.1.4.4
is described by: ECO:0000269
kinetic law: MODEL1310110002#
name: choline phosphatase
is: SBO:0000176
reversible: false
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_e1dc8563_d7b4_4cf4_beef_7ade0f4d1555
initial concentration: NaN
has only substance units: false
name: ACSL4
initial amount: NaN
is: Q5JWV8
type: Species
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:2182

http://identifiers.org/biomodels.db/MODEL1310110002#_492a36aa_4082_4516_8d90_fbe6b076f630
name: HEXA
initial amount: NaN
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is: P06865
is encoded by: hsa:3073
has only substance units: false

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaM gdpmann c
boundary condition: false
is: CHEBI:57527
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
is: SBO:0000247
is: HMDB01163
name: GDP-alpha-D-mannose(2-)

metaR EX cspg c LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate C (GalNAc6S-GlcA) proteoglycan exchange
type: Reaction

metaM retn r
initial concentration: 1.0
is: HMDB01852
name: all-trans-retinoate
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
is: SBO:0000247
type: Species
is: CHEBI:35291
initial amount: NaN
constant: false
boundary condition: false

metaM asp D c
has only substance units: false
is: CHEBI:29990
type: Species
name: D-aspartate(1-)
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB06483
initial amount: NaN
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
constant: false

metaR r1738
reactant: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110002#
reversible: false
kinetic law: MODEL1310110002#
name: Y+LAT2 Utilized transport

metaR EX leuktrF4 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene F4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_dcd88533_e98d_4143_aced_18aac4672361
initial concentration: NaN
has only substance units: false
name: _AA278423_1_c
is encoded by: hsa:AA278423
boundary condition: true
constant: false
initial amount: NaN
type: Species
is: SBO:0000252

metaR BTNDm
reactant: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (686.1) SUBSYSTEM: Biotin metabolism EC Number: 3.5.1.12 Confidence Level: 4 AUTHORS: PMID:12459313,PMID:15059618 NOTES:Also acts on biotin esters IT
is described by: ECO:0000269
reversible: false
name: biotinidase (biotin), mitochondrial
kinetic law: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.12
fast: false

metaR r1682
is described by: ECO:0000000
reactant: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000185
type: Reaction
reversible: false
fast: false
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
name: Y+LAT2 Utilized transport
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110002#_55335c2c_eb0a_4e51_8fc3_54f7642d41e6
type: Species
constant: false
has only substance units: false
name: BPNT1
initial amount: NaN
boundary condition: true
is encoded by: hsa:10380
is: SBO:0000252
is: O95861
initial concentration: NaN

metaM xol27oh m
is: HMDB02103
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
is: CHEBI:17703
name: 26-hydroxycholesterol
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18?,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C06340

metaR r0728
is: SBO:0000176
name: (S)-Hydroxydecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#

metaR RE3000M
type: Reaction
modifier: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is described by: ECO:0000000
name: RE3000
is: SBO:0000176

metaR r0502
type: Reaction
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.113
fast: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (1716.1) or (NM_001929.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:11246119,PMID:12632927 NOTES:
is described by: ECO:0000000
reversible: true
name: xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4

metaR GGH 10FTHF6GLUe
fast: false
reversible: false
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.4.19.9
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
name: Gamma-glutamyl hydrolase (10FTHF6GLU), extracellular
is described by: ECO:0000000
product: MODEL1310110002#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT

metaM CE4792 m
initial concentration: 1.0
name: 3-oxo-cis-8-tetradecenoyl-CoA
is: SBO:0000247
constant: false
is: CHEBI:57923
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C35H54N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-22,24,28-30,34,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4792
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_a85477eb_b192_46b0_9edb_9ba20ec168fc
type: Species
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
is encoded by: hsa:206
name: _206_1_c
is: SBO:0000252
boundary condition: true

metaR FUT15g
reversible: false
name: Galactoside 2-alpha-L-fucosyltransferase 1
modifier: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
kinetic law: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.69
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110002#
is: SBO:0000176

metaR ACt2r
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110002#
is described by: ECO:0000000
reversible: true
name: acetate reversible transport via proton symport
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_74a2f7a9_c9b9_4e61_ac64_779d93a8b7f5
is: Q9NTN3
is: SBO:0000252
constant: false
boundary condition: true
name: SLC35D1
initial amount: NaN
is encoded by: hsa:23169
type: Species
has only substance units: false
initial concentration: NaN

metaM HC02216 c
is: SBO:0000247
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
initial amount: NaN
is: CHEBI:28922
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: prostaglandin-f2beta

metaR EX lnlnca LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-Linolenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_88f797d2_d73e_4a68_a0d8_0787124ac237
type: Species
name: CMPK1
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:51727
boundary condition: true
is: SBO:0000252
is: B2R6S5
initial amount: NaN

metaM mercplaccys c
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
is: HMDB06512
has only substance units: false
is: SBO:0000247
name: 3-mercaptolactate-cysteine disulfide

metaR B3GNT11g
is described by: ECO:0000269
kinetic law: MODEL1310110002#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (10678.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
reactant: MODEL1310110002#
fast: false
product: MODEL1310110002#

metaM CE2705 c
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
boundary condition: false
constant: false
name: quinonoid dihydrobiopterin
is: CHEBI:36781
is: SBO:0000247
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_c4d98f57_4232_49a6_96c8_c80a44305d4f
boundary condition: true
is: SBO:0000252
name: CYP27A1
constant: false
has only substance units: false
type: Species
is encoded by: hsa:1593
is: Q02318
initial concentration: NaN
initial amount: NaN

metaR r1459
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
name: Transport reaction
reactant: MODEL1310110002#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110002#
is: SBO:0000185
type: Reaction

metaR EX fol LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Folate
type: Reaction

metaR B3GNT311g
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
type: Reaction
kinetic law: MODEL1310110002#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is: SBO:0000176
reactant: MODEL1310110002#
fast: false
product: MODEL1310110002#
reversible: false
is described by: ECO:0000254

metaR r1670
product: MODEL1310110002#
fast: false
modifier: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: true
kinetic law: MODEL1310110002#
is described by: ECO:0000000

metaR CYTK12n
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
name: cytidylate kinase (dCMP,dCTP),nuclear
reactant: MODEL1310110002#
fast: false
reversible: true
type: Reaction
product: MODEL1310110002#
is: SBO:0000176

metaR C204CPT2
is: SBO:0000176
type: Reaction
reactant: MODEL1310110002#
modifier: MODEL1310110002#
name: arachidonic acid transport into the mitochondria
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TDV C20:4 transport
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false

metaM apoC Lys btn c
is: CHEBI:32551
notes: FORMULA: C16H27N4O3SX CHARGE: 0
constant: false
boundary condition: false
is: HMDB00182
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN

metaM leuktrF4 e
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
name: leukotriene F4
type: Species
initial amount: NaN
is: CHEBI:27491
is: SBO:0000247
has only substance units: false
is: HMDB06465
constant: false
initial concentration: 1.0
boundary condition: false

metaM ksi pre14 g
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 14
notes: FORMULA: C143H230N10O114S4X CHARGE: -5
initial amount: NaN
has only substance units: false
is: CHEBI:28067

metaM ksii core2 deg3 l
is: CHEBI:12936
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
name: keratan sulfate II (core 2-linked), degradation product 3
is: HMDB00143
is: SBO:0000247
has only substance units: false
constant: false
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_239931bb_152e_4a7b_9a97_e62302b0f137
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5315
constant: false
has only substance units: false
is: P14618
initial concentration: NaN
name: PKM2

metaR MMEm
reactant: MODEL1310110002#
reversible: true
modifier: MODEL1310110002#
name: methylmalonyl-CoA epimerase/racemase
notes: GENE_ASSOCIATION: (84693.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.1.99.1 Confidence Level: 4 AUTHORS: PMID:11481338 NOTES:TDV
product: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.99.1
kinetic law: MODEL1310110002#
is described by: ECO:0000269
type: Reaction
fast: false

metaM thp2c c
is: HMDB12130
has only substance units: false
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
name: 1-piperideine-6-carboxylate
is: SBO:0000247
initial amount: NaN
is: CHEBI:16987

metaR r2410
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
type: Reaction
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_693280af_4c48_4764_bc3e_1dec420a37c3
initial amount: NaN
type: Species
has only substance units: false
constant: false
is encoded by: hsa:6240
has part: P31350
name: RRM1:RRM2
boundary condition: true
initial concentration: NaN
is: SBO:0000297
has part: P23921
is encoded by: hsa:6241

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_fa5f4686_946e_4095_ba7a_b8fe0e650614
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:23428
has part: Q86U05
initial concentration: NaN
is: SBO:0000297
name: SLC7A8:SLC3A2
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_0b1eb323_7e71_487f_9ab0_b2b3c4aee472
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:H77542
type: Species
name: _H77542_1_c
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_78ec87a0_460a_4f06_abe4_e0804dbd4b5a
initial amount: NaN
type: Species
is: Q15735
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: INPP5J
boundary condition: true
is encoded by: hsa:27124

metaM oxa e
initial amount: NaN
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
is: HMDB02329
has only substance units: false
is: SBO:0000247
name: oxalate(2-)
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
is: CHEBI:30623

metaR O2tn
fast: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
product: MODEL1310110002#
name: O2 nuclear transport
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_aee62e56_5084_4e62_9fca_807fbf958055
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000297
constant: false
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is encoded by: hsa:7991
has only substance units: false

metaR r1671
name: Y+LAT2 Utilized transport
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
modifier: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

metaM nm4masn g
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C54H90N3O40X CHARGE: 0
type: Species
is: C05882
initial concentration: 1.0
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)

metaR EX leugly LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylglycine
type: Reaction

metaM apoC Lys m
is: HMDB00182
is: SBO:0000247
constant: false
name: Apocarboxylase (Lys residue)
type: Species
notes: FORMULA: C6H13N2OX CHARGE: 0
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:32551
has only substance units: false

metaR 5ADTSTSTERONESte
name: sulfonated testosterone transport
is: SBO:0000185
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
reversible: true
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_acgalfuc12gal14acglcgalgluside_hs_g
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00304
constant: false
has only substance units: false
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
initial concentration: 1.0
notes: FORMULA: C58H102N3O31FULLRCO CHARGE: 0
is: CHEBI:57847
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_59f4e432_9b87_4507_8223_5d72181ff1f4
boundary condition: true
type: Species
initial concentration: NaN
is: Q6IBE6
constant: false
is: SBO:0000252
is encoded by: hsa:6484
name: ST3GAL4
has only substance units: false
initial amount: NaN

metaR DPCOAPPe
name: Pyrophasphatase (dephospho-CoA, extracellular)
notes: GENE_ASSOCIATION: SUBSYSTEM: CoA synthesis EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110002#
is described by: ECO:0000134
reactant: MODEL1310110002#
is: SBO:0000176
fast: false
reversible: false
type: Reaction
product: MODEL1310110002#

metaM 4h2oglt m
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: HMDB02070
is: CHEBI:17742
constant: false
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
name: 4-hydroxy-2-oxoglutarate(2-)

metaR RE1527M
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11451959 NOTES:
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
product: MODEL1310110002#
name: RE1527
reversible: true
kinetic law: MODEL1310110002#
is: SBO:0000176

metaR r0726
fast: false
type: Reaction
modifier: MODEL1310110002#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110002#
product: MODEL1310110002#
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is described by: ECO:0000000

metaM Asn X Ser Thr r
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: protein-linked asparagine residue (N-glycosylation site)
is: CHEBI:28938
is: HMDB00051
is: C01342
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: XH CHARGE: 0

metaR NACHEX5ly
type: Reaction
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
product: MODEL1310110002#
is described by: ECO:0000000
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
kinetic law: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
reactant: MODEL1310110002#
modifier: MODEL1310110002#
fast: false

metaM ksii core4 pre7 g
is: CHEBI:58053
type: Species
initial concentration: 1.0
is: HMDB00175
name: keratan sulfate II biosynthesis, precursor 7
boundary condition: false
constant: false
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: C00130
is: SBO:0000247
has only substance units: false
initial amount: NaN

metaR GLYC3PFADm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110002#
type: Reaction
name: glycerophosphate shuttle for trasnfer of reducing equivalents
reactant: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000134
reversible: false

metaR RE0958E
kinetic law: MODEL1310110002#
name: RE0958
is version of: http://identifiers.org/ec-code/3.2.1.17
product: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.1
modifier: MODEL1310110002#
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_69fbc527_a3bc_4b30_8ae1_5f1a60419904
type: Species
name: B3GNT7
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is: Q8NFL0
initial concentration: NaN
is encoded by: hsa:93010
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_2c2e2f41_0cc9_434d_8d45_da486689a3fe
is: Q53H96
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:65263
constant: false
is: SBO:0000252
name: PYCRL
boundary condition: true
has only substance units: false

metaR r0594
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
is described by: ECO:0000000
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
reversible: true
modifier: MODEL1310110002#
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
kinetic law: MODEL1310110002#
is: SBO:0000176
product: MODEL1310110002#

metaM leu L e
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
has only substance units: false
is: SBO:0000247
is: CHEBI:15603
constant: false
type: Species
initial amount: NaN
name: L-leucine
initial concentration: 1.0
is: HMDB00687
boundary condition: false

metaR O2tm
is: SBO:0000185
name: O2 transport (diffusion)
is described by: ECO:0000000
type: Reaction
fast: false
kinetic law: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
product: MODEL1310110002#

metaM 5htrp c
name: 5-hydroxy-L-tryptophan
constant: false
is: HMDB00472
is: CHEBI:17780
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false

metaR G14T4g
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.22
is described by: ECO:0000000
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
reversible: false

metaM cdpdag hs m
initial amount: NaN
type: Species
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC02078
name: CDP-diacylglycerol(2-)
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:58332

http://identifiers.org/biomodels.db/MODEL1310110002#_63a0d1df_0920_43f9_ada6_4da4a3d1ee62
name: SLC26A2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: P50443
boundary condition: true
initial amount: NaN
is encoded by: hsa:1836
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_b850cb15_e8c0_4c02_8f91_7f948bacde8a
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:56954
type: Species
name: NIT2
initial amount: NaN
is: Q9NQR4
has only substance units: false

metaM leuktrF4 c
type: Species
has only substance units: false
initial amount: NaN
is: CHEBI:27491
is: SBO:0000247
is: HMDB06465
initial concentration: 1.0
boundary condition: false
constant: false
notes: FORMULA: C28H42N2O8S CHARGE: -2 INCHI: InChI=1S/C28H44N2O8S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-24(23(31)15-14-17-26(33)34)39-20-22(28(37)38)30-25(32)19-18-21(29)27(35)36/h6-7,9-13,16,21-24,31H,2-5,8,14-15,17-20,29H2,1H3,(H,30,32)(H,33,34)(H,35,36)(H,37,38)/b7-6-,10-9-,12-11+,16-13+/t21-,22+,23+,24-/m1/s1
name: leukotriene F4

http://identifiers.org/biomodels.db/MODEL1310110002#_88c00f85_2ae9_40f1_889f_79cc30a8b061
constant: false
initial concentration: NaN
type: Species
name: NDUFB3
is encoded by: hsa:4709
has only substance units: false
is: Q6IB80
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM gluside hs c
constant: false
name: D-glucosyl-N-acylsphingosine
type: Species
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:18368
initial amount: NaN

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_482166cc_e023_4c1f_b5ef_a3be5109bb08
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
name: GLDC
is encoded by: hsa:2731
is: P23378
initial concentration: NaN
is: SBO:0000252

metaR DNDPt34m
is described by: ECO:0000269
modifier: MODEL1310110002#
is: SBO:0000185
reversible: false
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dGDP transport via dTDP antiport
product: MODEL1310110002#

metaR SPODM
is described by: ECO:0000269
kinetic law: MODEL1310110002#
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
reversible: false
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.15.1.1
modifier: MODEL1310110002#
name: superoxide dismutase
reactant: MODEL1310110002#

metaR AG13T1g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
product: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (374907.2) or (374907.1) or (146712.1) or (10331.1) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149

metaM hgentis c
initial concentration: 1.0
is: CHEBI:16169
type: Species
has only substance units: false
constant: false
name: homogentisate
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
is: HMDB00130

metaR S6T9g
kinetic law: MODEL1310110002#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
reversible: false
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_4ed29fd6_564c_410a_b30f_07dca45a94ce
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
name: HADHA
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:3030
is: E9KL44

metaR PI345P3P
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.67
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
is: SBO:0000176
reactant: MODEL1310110002#
reversible: false
type: Reaction

metaR RE1534M
is version of: http://identifiers.org/ec-code/2.3.1.16
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
modifier: MODEL1310110002#
product: MODEL1310110002#
name: RE1534
fast: false
is described by: ECO:0000000

metaM o2 x
boundary condition: false
is: C00007
initial amount: NaN
is: CHEBI:15379
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
has only substance units: false
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
name: O2
is: HMDB01377

metaM Asn X Ser Thr l
initial concentration: 1.0
name: protein-linked asparagine residue (N-glycosylation site)
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
constant: false
is: HMDB00051
is: CHEBI:28938
is: C01342
initial amount: NaN

metaR RTOTALt
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:
fast: false
product: MODEL1310110002#
is: SBO:0000185
type: Reaction
name: RTOTAL transport
is described by: ECO:0000000
reactant: MODEL1310110002#
reversible: true

metaR G12MT1 U
is described by: ECO:0000000
product: MODEL1310110002#
fast: false
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110002#_34a1af40_cd6d_47a4_bcf5_f47bec10ca9f
initial concentration: NaN
boundary condition: true
is encoded by: hsa:226
has only substance units: false
name: ALDOA
type: Species
constant: false
is: SBO:0000252
initial amount: NaN

metaM adpcoa x
constant: false
initial amount: NaN
name: adipoylcoa
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
is: C14143
boundary condition: false
has only substance units: false
is: HMDB04047
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR G6PDH2c
is: SBO:0000176
product: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
type: Reaction
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.49
name: glucose 6-phosphate dehydrogenase
reactant: MODEL1310110002#
is described by: ECO:0000134
reversible: false
notes: GENE_ASSOCIATION: (2539.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:found in rats. HMP shunt reactions are cytosolic. Irreversible reaction, coefficient changed to 3

metaR M13N2Tg
type: Reaction
product: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.101
kinetic law: MODEL1310110002#
reversible: false
is: SBO:0000176
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

metaM leu L c
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: SBO:0000247
initial concentration: 1.0
name: L-leucine
constant: false
is: CHEBI:15603
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00687

metaR r0596
is: SBO:0000176
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
reversible: false
modifier: MODEL1310110002#
reactant: MODEL1310110002#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_26b5560a_18a6_4ea3_9771_08aaaa5d23f4
boundary condition: true
name: _AI373818_1_m
constant: false
initial concentration: NaN
is encoded by: hsa:AI373818
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_80c31381_e2c2_472d_b5b6_7681e8090252
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
name: RDH14
is: Q9HBH5
is encoded by: hsa:57665
constant: false
boundary condition: true

metaM adp c
name: ADP
type: Species
is: HMDB01341
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3310
initial concentration: 1.0
is: CHEBI:16761
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: C00008

metaM 1pipdn2c x
type: Species
constant: false
is: CHEBI:16187
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01084
has only substance units: false
name: 1-piperideine-2-carboxylate
notes: FORMULA: C6H9NO2 CHARGE: 0 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h1-4H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C04092

metaM paf hs c
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
constant: false
is: CHEBI:36707
type: Species
name: 1-alkyl 2-acteylglycerol 3-phosphocholine

http://identifiers.org/biomodels.db/MODEL1310110002#_9568df01_efbf_43f1_b12a_484010ae53b4
is encoded by: hsa:2878
initial amount: NaN
name: GPX3
is: P22352
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_07281cc8_d0d4_437e_aac5_27219f7d5eca
has only substance units: false
type: Species
is encoded by: hsa:200010
is: SBO:0000252
is: E9PAK4
name: SLC5A9
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true

metaM thf c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:57453
boundary condition: false
is: SBO:0000247
is: HMDB01846
is: C00101
has only substance units: false
constant: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
type: Species
name: 5,6,7,8-Tetrahydrofolate

metaM hxan e
constant: false
boundary condition: false
initial concentration: 1.0
name: hypoxanthine
notes: FORMULA: C5H4N4O CHARGE: 0 INCHI: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
has only substance units: false
initial amount: NaN
is: CHEBI:17368
type: Species
is: SBO:0000247
is: HMDB00157

http://identifiers.org/biomodels.db/MODEL1310110002#_c304a956_f2b9_4859_b410_1b81141c50cb
initial concentration: NaN
is: P37837
is encoded by: hsa:6888
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: TALDO1
boundary condition: true

metaM acnam c
boundary condition: false
name: N-acetylneuraminate
type: Species
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
has only substance units: false
is: CHEBI:35418
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00230
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_28408c4a_a311_4484_89b4_f9c395fa6671
is encoded by: hsa:586
name: BCAT1
has only substance units: false
is: P54687
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true

metaM asp D e
is: SBO:0000247
constant: false
boundary condition: false
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
type: Species
initial amount: NaN
name: D-aspartate(1-)
initial concentration: 1.0
has only substance units: false
is: CHEBI:29990
is: HMDB06483

metaM m3mpdol U c
boundary condition: false
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
has only substance units: false
initial amount: NaN
is: CHEBI:37632
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
constant: false

metaM guln c
is: HMDB03290
name: L-gulonate
constant: false
type: Species
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:13115
initial amount: NaN

metaM hexdiac r
notes: FORMULA: C16H28O4 CHARGE: -2
name: hexadecanediocacid
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
is: HMDB00672
initial amount: NaN
is: SBO:0000247
is: C08260

http://identifiers.org/biomodels.db/MODEL1310110002#_23578dc5_3d47_4a13_a772_852fd6689ea3
name: MTMR1
is encoded by: hsa:8776
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
is: Q13613

metaR r0504
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
name: Xanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (AI090874.1) or (AL048840.1) or (BG035985.1) or (3157.1) or (3158.1) SUBSYSTEM: Purine catabolism EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:16087479,PMID:1643670,PMID:16756494,PMID:18600557,PMID:8343533 NOTES:
is version of: http://identifiers.org/ec-code/2.3.3.10
reactant: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
fast: false

metaR CYTK4n
reactant: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110002#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
name: cytidylate kinase (dCMP,GTP),nuclear
reversible: true
modifier: MODEL1310110002#

metaR MCLOR
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.27
name: 3-Mercaptolactate:NAD+ oxidoreductase
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
is: SBO:0000176
type: Reaction
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_fc3ff375_335b_40f6_a5f9_2df8126cbae9
is encoded by: hsa:123041
constant: false
initial concentration: NaN
has only substance units: false
is: Q8NFF2
is: SBO:0000252
name: SLC24A4
type: Species
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_dc05928a_f001_43f6_be8d_99faaadc6711
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
type: Species
is: P05187
is encoded by: hsa:250
name: ALPP
initial amount: NaN

metaR r0377
is: SBO:0000176
name: ATP:deoxycitidine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.74
is described by: ECO:0000000
reactant: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: false
modifier: MODEL1310110002#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AI653169.1) or (203.1) or (204.1) or (205.1) or (206.1) or (26289.1) or (122481.1) or (AW277253.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 2.7.1.74 Confidence Level: 0 AUTHORS: PMID:12036920,PMID:1657002,PMID:213049,PMID:8399394,PMID:9342341,PMID:9593124 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.3

http://identifiers.org/biomodels.db/MODEL1310110002#_6a2d1fea_4168_4a77_bc0c_fe722534c11d
constant: false
is encoded by: hsa:23517
type: Species
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q3MHC9
initial amount: NaN
name: SKIV2L2
is: SBO:0000252

metaR GLCURtly
is: SBO:0000185
name: glucuronate transport into lysososme
is described by: ECO:0000269
reversible: true
fast: false
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#

metaM so3 m
boundary condition: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
is: SBO:0000247
is: HMDB00240
has only substance units: false
is: CHEBI:17137
name: hydrogensulfite
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_51d78da3_4df2_437a_b7ec_e2979170ceed
is: SBO:0000297
constant: false
has part: P15531
is encoded by: hsa:4830
has only substance units: false
is encoded by: hsa:4831
name: NME1:NME2
initial concentration: NaN
boundary condition: true
initial amount: NaN
has part: P22392
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_cf60afb4_c29e_47dd_9137_3c095ebd8acb
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is: Q96Q11
name: TRNT1
is encoded by: hsa:51095
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_27cd0f9b_dd62_4b4a_ab12_9688db2be002
initial amount: NaN
constant: false
has only substance units: false
is: Q9BZX2
is encoded by: hsa:7371
type: Species
name: UCK2
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR S6TASE6ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110002#
reversible: true
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110002#
type: Reaction
name: N-acetylgalactosamine-6-sulfatase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110002#_6139c200_bc9e_488b_98bb_d2546609e780
initial amount: NaN
is: SBO:0000252
is: P24752
is encoded by: hsa:38
boundary condition: true
initial concentration: NaN
constant: false
type: Species
name: ACAT1
has only substance units: false

metaR AG13T9g
product: MODEL1310110002#
reversible: false
fast: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_e22e7b00_a6b3_42c1_a431_76d39ec81df5
is: SBO:0000252
is encoded by: hsa:257068
initial amount: NaN
name: PLCXD2
constant: false
has only substance units: false
boundary condition: true
is: Q0VAA5
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_3181a40b_933d_4ee6_8556_dea8b8646ae9
is: SBO:0000252
is encoded by: hsa:956
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
is: O75355
initial amount: NaN
name: ENTPD3
constant: false

metaM HC02216 e
name: prostaglandin-f2beta
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
is: CHEBI:28922

metaR r1961
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_3d70f41d_aa45_44b7_95df_fde64d11daef
is: SBO:0000252
is encoded by: hsa:353
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
name: APRT
initial amount: NaN
type: Species
is: P07741

metaM r5p r
name: alpha-D-Ribose 5-phosphate
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:18189
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-3-2(1-12-14(9,10)11)13-5(8)4(3)7/h2-8H,1H2,(H2,9,10,11)/t2-,3-,4-,5+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
type: Species
has only substance units: false
is: HMDB00618
constant: false

metaM accoa c
is: HMDB01206
boundary condition: false
is: C00024
initial amount: NaN
type: Species
has only substance units: false
name: Acetyl-CoA
initial concentration: 1.0
is: CHEBI:57288
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: SBO:0000247
constant: false

metaM paf hs e
is: CHEBI:36707
initial concentration: 1.0
type: Species
name: 1-alkyl 2-acteylglycerol 3-phosphocholine
notes: FORMULA: C11H23O4NPFULLRCO2 CHARGE: 0
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN

metaR ADRNCOAtx
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
is described by: ECO:0000000
name: fatty acid intracellular transport
is: SBO:0000185
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#

metaR BHBtm
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:3427918 NOTES:IT, TDV
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110002#
name: (R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
type: Reaction
kinetic law: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_03312555_42c7_4707_ad81_30266058d5a9
is: Q5DSZ6
is: SBO:0000252
is encoded by: hsa:54576
has only substance units: false
boundary condition: true
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: UGT1A8

http://identifiers.org/biomodels.db/MODEL1310110002#_71245f6f_fe25_481a_9397_6a71006889b2
constant: false
name: ECHS1
type: Species
boundary condition: true
is: P30084
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:1892
initial concentration: NaN

metaM hxan c
constant: false
name: Hypoxanthine
notes: FORMULA: C5H4N4O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00238 EHMN_ABBREVIATION: C00262
is: C00262
is: CHEBI:17368
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00157
boundary condition: false
initial amount: NaN
has only substance units: false

metaR FAOXC16080m
type: Reaction
kinetic law: MODEL1310110002#
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_68be38ca_89de_4dd3_a5f0_a2c3156b3e03
name: ACAA1
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:30
initial concentration: NaN
is: Q96CA6
has only substance units: false
boundary condition: true

metaR RE3627M
reversible: true
is described by: ECO:0000000
is: SBO:0000176
fast: false
name: RE3627
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_5152db01_e23d_4292_a64f_65795d3bf9c8
has only substance units: false
type: Species
is: SBO:0000252
name: CPT1C
boundary condition: true
is: Q8TCG5
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:126129

metaR PCHOLPr hs
modifier: MODEL1310110002#
is: SBO:0000176
name: choline phosphatase
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ
kinetic law: MODEL1310110002#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.4
fast: false
reversible: false
product: MODEL1310110002#
reactant: MODEL1310110002#

metaR PI45P4P
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
kinetic law: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
reversible: false
fast: false
type: Reaction

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_0592a181_b347_47ee_acd9_fae222aaeb36
type: Species
has only substance units: false
is: Q9UFY1
constant: false
boundary condition: true
is: SBO:0000252
name: PLCG1
is encoded by: hsa:5335
initial concentration: NaN
initial amount: NaN

metaM CE2431 m
has only substance units: false
initial amount: NaN
boundary condition: false
name: cis-deca-4-enoyl-CoA
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57795

metaR AKR1C41
type: Reaction
product: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 4 AUTHORS: NOTES:NJ
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
reactant: MODEL1310110002#
is: SBO:0000176
reversible: false
modifier: MODEL1310110002#
is described by: ECO:0000269

metaR r2354
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is described by: ECO:0000000
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
type: Reaction
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_613dcb55_2a1e_42ba_bfad_46c12a5215d9
is: SBO:0000252
boundary condition: true
is encoded by: hsa:3612
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: NaN
is: B7Z6Q4
name: IMPA1

metaM sphgn c
is: HMDB00269
constant: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:57817
name: sphinganine(1+)
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
has only substance units: false

metaR RE0512M
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (3030.1) or (3295.1) or (1962.1) or (3033.1) or (3028.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:7846063 NOTES:
product: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.107
name: RE0512
reactant: MODEL1310110002#

metaR HEX7
reactant: MODEL1310110002#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.1
notes: GENE_ASSOCIATION: (2645.2) or (2645.3) or (3098.3) or (3098.1) or (3101.1) or (3098.2) or (3099.1) or (2645.1) or (3098.4) or (80201.1) or (3098.5) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. Same as 2.7.1.4
type: Reaction
is described by: ECO:0000304
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.1.2
name: hexokinase (D-fructose:ATP)
is: SBO:0000176

metaR FAOXC10C8x
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaR r2406
type: Reaction
reactant: MODEL1310110002#
reversible: false
product: MODEL1310110002#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110002#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaR OAGD3te
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
kinetic law: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110002#
type: Reaction
reversible: true
name: oagd3 hs transport
product: MODEL1310110002#

metaM 4fumacac c
constant: false
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061
initial concentration: 1.0
is: CHEBI:18034
is: HMDB01268
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
name: 4-fumarylacetoacetate(2-)
has only substance units: false

metaR r1666
product: MODEL1310110002#
name: Y+LAT2 Utilized transport
is: SBO:0000185
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
fast: false
type: Reaction
modifier: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_7e07282d_665e_4f6d_bfa1_81e85dc54a7c
is: SBO:0000252
initial concentration: NaN
is: P36021
boundary condition: true
type: Species
has only substance units: false
initial amount: NaN
name: SLC16A2
constant: false
is encoded by: hsa:6567

metaR r1677
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110002#
reversible: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000185
fast: false
type: Reaction
is described by: ECO:0000000
name: Y+LAT2 Utilized transport

http://identifiers.org/biomodels.db/MODEL1310110002#_80c0a36d_9e52_4107_aba4_9a17749ab250
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:U37519
has only substance units: false
initial amount: NaN
name: _U37519_1_m

http://identifiers.org/biomodels.db/MODEL1310110002#_5df4b405_1163_44c8_871f_83cafe93db4e
boundary condition: true
name: GALNT5
has only substance units: false
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
is: A5PKZ1
is: SBO:0000252
is encoded by: hsa:11227

http://identifiers.org/biomodels.db/MODEL1310110002#_edc1e6ee_3f17_4bcd_89f5_d51020114c20
is encoded by: hsa:54344
constant: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is: Q86TM7
name: DPM3
type: Species
initial amount: NaN
has only substance units: false

metaR r1665
reversible: true
type: Reaction
name: Y+LAT2 Utilized transport
reactant: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110002#_23125f0a_7677_491c_b656_975fc092b41f
initial concentration: NaN
type: Species
is encoded by: hsa:6120
is: Q96AT9
name: RPE
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaR r1464
name: Active transport
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 1.3.1.27 Confidence Level: 0 AUTHORS: NOTES:
fast: false
reactant: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000

metaM guln r
type: Species
is: HMDB03290
has only substance units: false
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
boundary condition: false
name: L-gulonate
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:13115

http://identifiers.org/biomodels.db/MODEL1310110002#_6e6e27d2_6a65_4d6b_93d0_c830d4eee753
boundary condition: true
is encoded by: hsa:8836
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: GGH
is: Q92820
initial amount: NaN
constant: false
type: Species

metaR r2355
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
kinetic law: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110002#
reversible: true
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110002#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_425f6c4d_7949_42e1_88e6_42e9ae68a282
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:1621
initial concentration: NaN
constant: false
is: P09172
name: DBH

metaR r0720
reversible: false
reactant: MODEL1310110002#
is: SBO:0000176
name: (S)-3-Hydroxytetradecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_7d63fa85_9a8f_47a8_a1a6_75ea376f7e77
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P17812
name: CTPS1
boundary condition: true
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:1503

metaM HC00319 m
is: SBO:0000247
name: Malonate
type: Species
has only substance units: false
constant: false
is: CHEBI:30794
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR ABO7g
type: Reaction
is: SBO:0000176
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.37
fast: false
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
product: MODEL1310110002#
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000269

metaM glyc c
boundary condition: false
is: SBO:0000247
is: HMDB00131
has only substance units: false
is: C00116
initial amount: NaN
name: Glycerol
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: CHEBI:17754
constant: false
initial concentration: 1.0
type: Species

metaM HC01223 m
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
initial amount: NaN
constant: false
is: CHEBI:57340
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110002#_a1aed975_983c_40b3_8270_050bf52c5ec6
boundary condition: true
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:570
has only substance units: false
initial concentration: NaN
is: Q14032
name: BAAT
type: Species

metaR O2ter
is: SBO:0000185
fast: false
reactant: MODEL1310110002#
reversible: true
name: O2 transport, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
kinetic law: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_6e145f98_5a32_4851_84d6_3418f2201eb0
is encoded by: hsa:728226
is: SBO:0000252
type: Species
name: _728226_1_e
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_89cb137c_09c2_46b6_98f8_fc4ee1f3fd96
initial concentration: NaN
name: SLC7A8:SLC3A2
constant: false
type: Species
is encoded by: hsa:23428
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000297
has part: Q9UHI5

metaM CE0693 m
initial amount: NaN
name: 3-oxolaur-6-cis-enoyl-CoA
is: SBO:0000247
is: CHEBI:28387
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
type: Species
initial concentration: 1.0
is: HMDB11123
has only substance units: false
boundary condition: false
constant: false

metaR GUAt
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
reactant: MODEL1310110002#
is: SBO:0000185
name: Guanine transport
modifier: MODEL1310110002#
fast: false
type: Reaction
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_0ac3a6f4_174d_4fa6_8256_5f7df20bde27
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
name: _AA854479_1_m
has only substance units: false
is encoded by: hsa:AA854479

metaR r0509
name: Succinate:ubiquinone oxidoreductase Citrate cycle (TCA cycle) EC:1.3.5.1
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Citric acid cycle EC Number: 1.3.5.1 Confidence Level: 0 AUTHORS: PMID:2843227 NOTES:
reversible: false
kinetic law: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
fast: false
type: Reaction
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_0f205b42_fe18_4c8b_95b0_8bd82f1bf270
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
name: DGKB
initial concentration: NaN
is encoded by: hsa:1607
constant: false

metaM HC01405 m
has only substance units: false
name: (S)-Hydroxyoctanoyl-CoA
type: Species
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
boundary condition: false
initial amount: NaN
is: CHEBI:28632
constant: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_1658f428_1f7a_41fc_a505_75c8f55f0e1e
boundary condition: true
name: SLC25A21
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is: G3V4L5
is encoded by: hsa:89874
is: SBO:0000252
initial amount: NaN

metaR r2497
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:18619829 NOTES:
type: Reaction
product: MODEL1310110002#
fast: false
reversible: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.203.3
is described by: ECO:0000000
kinetic law: MODEL1310110002#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_114d96c8_483d_44ee_93ca_5cf123f99519
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: FOLR1
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:2348

metaR OAGD3tg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
type: Reaction
name: oagd3 hs intracellular transport
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000185
reactant: MODEL1310110002#
fast: false
reversible: true

metaR r2356
is described by: ECO:0000000
product: MODEL1310110002#
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
fast: false
type: Reaction
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_2df80db0_8956_4337_992c_8609cccc9e18
constant: false
name: ACO1
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: P21399
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:48

http://identifiers.org/biomodels.db/MODEL1310110002#_315912e8_70e4_4650_bd0b_df5a1a431af5
name: _642502_1_c
type: Species
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:642502

metaR r1668
product: MODEL1310110002#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110002#
is: SBO:0000185
reactant: MODEL1310110002#
is described by: ECO:0000000
reversible: true
type: Reaction
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM HC00695 m
boundary condition: false
type: Species
constant: false
name: S-Succinyldihydrolipoamide
is: CHEBI:17432
is: SBO:0000247
has only substance units: false
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_82559b5c_7084_4c93_8005_252670636696
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
name: VNN3
has only substance units: false
is encoded by: hsa:55350
constant: false
initial amount: NaN

metaR GGH 5THFe
is: SBO:0000176
fast: false
product: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
kinetic law: MODEL1310110002#
name: Gamma-glutamyl hydrolase (5THF), extracellular
type: Reaction
reactant: MODEL1310110002#
is described by: ECO:0000000
reversible: false

metaR EX phe L LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-phenylalanine
type: Reaction

metaR FUCASEly
reactant: MODEL1310110002#
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.51
modifier: MODEL1310110002#
type: Reaction
reversible: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
name: alpha-fucosidase, lysosomal
notes: GENE_ASSOCIATION: (2517.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD

metaM mescoa m
boundary condition: false
type: Species
is: C06028
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:27969
is: SBO:0000247
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
initial amount: NaN
name: Mesaconyl-CoA

metaR r2357
fast: false
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
is: SBO:0000185
reversible: true
product: MODEL1310110002#

metaR r1252
product: MODEL1310110002#
fast: false
name: EC:6.2.1.3
reversible: false
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110002#

metaR DOLDPP Uer
modifier: MODEL1310110002#
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
reactant: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.43
reversible: false
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110002#
is: SBO:0000176
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD

metaR EX gchola LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycocholate exchange
type: Reaction

metaM dhcholestanate c
initial amount: NaN
initial concentration: 1.0
is: CHEBI:16577
has only substance units: false
constant: false
is: HMDB00359
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
type: Species
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_0c947c95_4b3d_47af_ad44_6e95c57c41e2
initial amount: NaN
has only substance units: false
is: O75452
boundary condition: true
name: RDH16
type: Species
is: SBO:0000252
is encoded by: hsa:8608
initial concentration: NaN
constant: false

metaR r2403
reactant: MODEL1310110002#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
is: SBO:0000185
kinetic law: MODEL1310110002#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
type: Reaction
reversible: false
product: MODEL1310110002#

metaM icit c
type: Species
initial concentration: 1.0
is: CHEBI:16087
has only substance units: false
is: SBO:0000247
name: Isocitrate
is: C00311
initial amount: NaN
constant: false
is: HMDB00193
boundary condition: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311

http://identifiers.org/biomodels.db/MODEL1310110002#_88fce297_c3b4_4ae8_b588_5efcf17244c7
has only substance units: false
has part: O95299
has part: P03897
is encoded by: hsa:4716
boundary condition: true
has part: O43181
is encoded by: hsa:4728
has part: Q6IBB5
initial concentration: NaN
is encoded by: hsa:4539
type: Species
has part: P56181
is encoded by: hsa:4731
has part: C9JT23
has part: P03915
has part: P03905
constant: false
has part: B7Z792
is encoded by: hsa:4724
is encoded by: hsa:4698
is encoded by: hsa:4717
has part: Q7GXZ4
has part: O95169
is encoded by: hsa:4540
is encoded by: hsa:4708
initial amount: NaN
is encoded by: hsa:4705
is encoded by: hsa:4697
has part: Q16718
is encoded by: hsa:4713
has part: O75438
has part: Q13454
is encoded by: hsa:4711
is encoded by: hsa:4729
has part: P19404
has part: B1AM93
has part: Q85KV6
is encoded by: hsa:4694
is encoded by: hsa:4720
is encoded by: hsa:51079
has part: Q9Y6M9
has part: Q549M5
has part: Q6IBA0
is encoded by: hsa:4706
has part: O00483
has part: E5KNH5
name: NDUFA11:NDUFS7:ND1:ND2:ND3:ND4:ND4L:ND5:ND6:NDUFA1:NDUFA2:NDUFA3:NDUFA4:NDUFA5:NDUFA6:NDUFA7:NDUFA8:NDUFA9:NDUFA10:NDUFAB1:NDUFB1:NDUFB2:NDUFB3:NDUFB4:NDUFB5:NDUFB6:NDUFB7:NDUFB8:NDUFB9:NDUFB10:NDUFC1:NDUFC2:NDUFS1:NDUFS2:NDUFS3:NDUFV1:NDUFS4:NDUFS5:NDUFS6:NDUFS8:NDUFV2:NDUFV3:NDUFA13:NDUFA12:TUSC3
is encoded by: hsa:4541
is encoded by: hsa:4725
is encoded by: hsa:4537
is encoded by: hsa:4718
is encoded by: hsa:4723
has part: O95167
has part: O95139
is encoded by: hsa:4709
is encoded by: hsa:4702
has part: O95168
has part: O00217
is encoded by: hsa:4700
has part: O75251
is: SBO:0000297
is encoded by: hsa:4714
is encoded by: hsa:4712
is encoded by: hsa:126328
has part: Q16795
has part: P28331
is encoded by: hsa:4535
is encoded by: hsa:4695
is encoded by: hsa:55967
is encoded by: hsa:374291
has part: O43674
has part: O43678
is encoded by: hsa:4715
has part: Q6FG42
has part: A8K761
has part: Q9P0J0
has part: O75489
has part: O43677
has part: Q6IB80
is encoded by: hsa:7991

metaR O2t
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
fast: false
is described by: ECO:0000000
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
name: o2 transport (diffusion)

metaR LINKDEG3ly
name: degradation of proteoglycan linkage region, lysosomal
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction

metaM gthrd m
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: glutathionate(1-)
is: CHEBI:57925
constant: false
is: HMDB00125
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_c9baddc4_0610_4418_b20d_848b706b42e3
is encoded by: hsa:3635
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: INPP5D
is: Q92835
has only substance units: false
initial amount: NaN

metaM nad x
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3305
name: Nicotinamide adenine dinucleotide
is: CHEBI:57540
boundary condition: false
is: C00003
is: SBO:0000247
is: HMDB00902
initial amount: NaN

metaR RE2660N
modifier: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:8921004 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96
product: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
fast: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110002#
name: RE2660

http://identifiers.org/biomodels.db/MODEL1310110002#_d7b80492_a3d9_4885_b688_78343c38af7b
initial concentration: NaN
initial amount: NaN
constant: false
name: PAFAH1B2:PAFAH1B3
has part: Q15102
is encoded by: hsa:5050
is encoded by: hsa:5049
is: SBO:0000297
boundary condition: true
has part: A8DPS7
has only substance units: false
type: Species

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaM lnlnca c
constant: false
is: CHEBI:32387
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: alpha-linolenate
initial amount: NaN
type: Species
is: HMDB01388
is: SBO:0000247

metaM cs e deg3 l
is: HMDB00127
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:15748
notes: FORMULA: C37H53NO44S4 CHARGE: -6
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 3
boundary condition: false
type: Species
constant: false

metaR 2OXOADOXm
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) SUBSYSTEM: Lysine metabolism EC Number: 2.3.1.61 Confidence Level: 2 AUTHORS: NOTES:SAB
is version of: http://identifiers.org/ec-code/1.8.1.4
name: 2-Oxoadipate:lipoamde 2-oxidoreductase(decarboxylating and acceptor-succinylating) (mitochondria)
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.2.4.2
is version of: http://identifiers.org/ec-code/2.3.1.61
modifier: MODEL1310110002#
is described by: ECO:0000304
type: Reaction
fast: false
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110002#_c3330c74_bbac_4d2c_a2a3_870bef77f48c
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:347734
initial amount: NaN
constant: false
has only substance units: false
is: Q8TB61
name: SLC35B2
type: Species

metaM dpcoa e
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
boundary condition: false
type: Species
name: Dephospho-CoA
is: SBO:0000247
initial amount: NaN
is: CHEBI:57328
constant: false
initial concentration: 1.0
is: HMDB01373
has only substance units: false
is: C00882

metaR LALDO
fast: false
reversible: true
reactant: MODEL1310110002#
is described by: ECO:0000000
modifier: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
is version of: http://identifiers.org/ec-code/1.1.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
kinetic law: MODEL1310110002#

metaR BPNT
reactant: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.1.3.7
product: MODEL1310110002#
reversible: false
kinetic law: MODEL1310110002#
name: 3',5'-bisphosphate nucleotidase
fast: false
type: Reaction
is described by: ECO:0000269

metaR GLCAASE8ly
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
product: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.31
name: beta-glucuronidase, lysosomal
reactant: MODEL1310110002#
is: SBO:0000176
reversible: false

metaR r1467
reversible: true
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
name: Postulated transport reaction
fast: false
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: 2.3.1.86 Confidence Level: 0 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110002#_876be78d_deac_4522_bd6f_6f09b0f74d54
is encoded by: hsa:5476
has only substance units: false
is encoded by: hsa:4758
has part: P16278
initial amount: NaN
has part: Q99519
boundary condition: true
name: GALNS:GLB1:NEU1:CTSA
type: Species
constant: false
is encoded by: hsa:2588
has part: P10619
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:2720
has part: P34059

metaR r0156
reactant: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
product: MODEL1310110002#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
is version of: http://identifiers.org/ec-code/2.7.1.40
fast: false
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_dbf3c4c8_f10f_4944_996d_a9755195f64b
initial amount: NaN
constant: false
name: GLUD1
type: Species
initial concentration: NaN
is: E9KL48
has only substance units: false
is encoded by: hsa:2746
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_74431fcf_3227_4533_9181_711d414e3a68
initial concentration: NaN
name: ACAT2
type: Species
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
is: Q9BWD1
is encoded by: hsa:39
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_a8343b71_c693_4490_9a5a_7fa886cae810
is encoded by: hsa:51
constant: false
is: SBO:0000252
type: Species
boundary condition: true
name: ACOX1
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q15067

metaR FAOXC14C12x
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_f287bb0e_5e47_4a16_813e_0bd632c8bc36
name: SLC38A5
initial concentration: NaN
is: Q8WUX1
is: SBO:0000252
constant: false
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:92745

metaM acnam l
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00230
is: CHEBI:35418
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
name: N-acetylneuraminate

metaM CE5120 m
boundary condition: false
is: SBO:0000247
is: CHEBI:57923
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: trans-2-cis-8-tetradecadienoyl-CoA
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,14-15,22-24,28-30,34,45-46H,4-7,10-13,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5120
type: Species
constant: false

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

metaM 3dhguln c
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:57655
notes: FORMULA: C6H9O7 CHARGE: -1 INCHI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-3,5,7-9,11H,1H2,(H,12,13)/p-1/t2-,3+,5-/m0/s1
name: 3-dehydro-L-gulonate
is: HMDB06334

metaR HEX1
product: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.2
type: Reaction
fast: false
kinetic law: MODEL1310110002#
name: hexokinase (D-glucose:ATP)
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (3098.3) or (80201.1) or (2645.3) or (3098.4) or (3099.1) or (2645.2) or (3098.5) or (2645.1) or (3098.1) or (3101.1) or (3098.2) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
reactant: MODEL1310110002#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.1

http://identifiers.org/biomodels.db/MODEL1310110002#_f0a2b385_46b9_4360_a0b2_f5299db6f148
type: Species
is: SBO:0000252
name: ALDH3B2
initial amount: NaN
initial concentration: NaN
is: P48448
boundary condition: true
is encoded by: hsa:222
constant: false
has only substance units: false

metaM dhcrm hs c
is: CHEBI:31488
initial amount: NaN
name: dihydroceramide
type: Species
initial concentration: 1.0
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false

metaR r0724
is version of: http://identifiers.org/ec-code/2.7.1.33
is: SBO:0000176
reversible: true
reactant: MODEL1310110002#
modifier: MODEL1310110002#
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is described by: ECO:0000000
product: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
fast: false

metaM dlnlcgcoa c
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C41H64N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h8-9,11-12,14-15,28-30,34-36,40,51-52H,4-7,10,13,16-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/b9-8-,12-11-,15-14-/t30-,34-,35-,36+,40-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC02102
type: Species
constant: false
is: CHEBI:27979
is: SBO:0000247
initial amount: NaN
name: dihomo-gamma-linolenyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110002#_9a4ab8fc_d8ed_45fa_8795_4d398b62f208
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: DDOST
is encoded by: hsa:1650
boundary condition: true
is: P39656
is: SBO:0000252
type: Species
constant: false

metaR r0157
modifier: MODEL1310110002#
is described by: ECO:0000000
fast: false
product: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.3.4.2
kinetic law: MODEL1310110002#
reversible: false
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
type: Reaction

metaR G6PDH1rer
fast: false
modifier: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
is version of: http://identifiers.org/ec-code/1.1.1.47
type: Reaction
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
is described by: ECO:0000269
reactant: MODEL1310110002#
is: SBO:0000176

metaR r1669
fast: false
is: SBO:0000185
product: MODEL1310110002#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM betald c
boundary condition: false
name: betaine aldehyde
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
has only substance units: false
type: Species
constant: false
is: CHEBI:15710
is: HMDB01252
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_c9b4de5c_fc95_45e4_986c_dff996fe112d
initial concentration: NaN
is: Q92903
constant: false
type: Species
name: CDS1
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1040

metaM acglcgal14acglcgalgluside hs g
constant: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17103
type: Species
notes: FORMULA: C52H92N3O27FULLRCO CHARGE: 0
has only substance units: false
is: SBO:0000247
name: nLc5Cer

metaM 42A3HP24DB c
initial concentration: 1.0
constant: false
is: C05645
initial amount: NaN
name: 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
is: HMDB04083
has only substance units: false
boundary condition: false
notes: FORMULA: C10H8NO5 CHARGE: -1 INCHI: InChI=1/C10H9NO5/c11-9-5(2-1-3-6(9)12)7(13)4-8(14)10(15)16/h1-3,12H,4,11H2,(H,15,16) HEPATONET_1.0_ABBREVIATION: HC01547 EHMN_ABBREVIATION: C05645
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/7956
type: Species

metaM prostge2 c
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
boundary condition: false
name: prostaglandin E2(1-)
is: HMDB01220
is: CHEBI:606564
constant: false
is: SBO:0000247

metaM HC01496 m
type: Species
name: 2-Amino-3-oxoadipate
has only substance units: false
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:28095
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
boundary condition: false
is: SBO:0000247

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

metaR EX pe hs LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for phosphatidylethanolamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_0c40ccc9_86c9_478c_b5d3_b95083c5700c
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: FLAD1
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:80308

metaM itp n
constant: false
initial concentration: 1.0
type: Species
is: HMDB00189
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
name: ITP(3-)
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:57614

metaR r2352
fast: false
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
type: Reaction
reactant: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:

metaM lnlnca e
is: CHEBI:32387
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9-
boundary condition: false
initial amount: NaN
is: HMDB01388
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
constant: false
name: alpha-linolenate

metaR HEX4
notes: GENE_ASSOCIATION: (3098.2) or (2645.2) or (3098.3) or (2645.3) or (3098.4) or (3099.1) or (3098.5) or (3098.1) or (3101.1) or (80201.1) or (2645.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.7 Confidence Level: 2 AUTHORS: NOTES:D-Glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. also active in ecoli PMID: 4557975
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.1.2
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.1
reversible: false
reactant: MODEL1310110002#
name: hexokinase (D-mannose:ATP)
modifier: MODEL1310110002#

metaR r0723
product: MODEL1310110002#
modifier: MODEL1310110002#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
reversible: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.85
is version of: http://identifiers.org/ec-code/2.3.1.41
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
is: SBO:0000176

metaM ala L m
is: HMDB00161
is: SBO:0000247
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00048
constant: false
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: L-alanine
is: CHEBI:16977

http://identifiers.org/biomodels.db/MODEL1310110002#_72ea2169_53c7_423b_9c25_50ba0a13f5ab
constant: false
is: Q9H310
name: RHBG
has only substance units: false
boundary condition: true
is encoded by: hsa:57127
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_eb28fd79_4ce7_40ef_b2de_32d3a539a2bb
name: NDUFA8
initial amount: NaN
is: B1AM93
type: Species
is encoded by: hsa:4702
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false

metaR HISTAtu
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
reversible: true
is described by: ECO:0000269
name: Histamine uniport
is: SBO:0000185
product: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
fast: false
kinetic law: MODEL1310110002#

metaM HC01104 e
has only substance units: false
initial amount: NaN
name: 4-nitrophenyl phosphate(2-)
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
notes: FORMULA: C6H4NO6P CHARGE: -2 INCHI: InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)/p-2 EHMN_ABBREVIATION: C03360
constant: false
is: CHEBI:61146

metaM didp n
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
has only substance units: false
name: dIDP
is: HMDB03536
boundary condition: false
type: Species
initial concentration: 1.0
is: CHEBI:28823
initial amount: NaN
constant: false
is: SBO:0000247

metaR FOLt2le
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110002#
name: folate transport via anion exchange
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_8e84ac19_446b_411e_a4ed_c39022fe6162
initial concentration: NaN
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2639
initial amount: NaN
name: GCDH
constant: false
boundary condition: true

metaR AICARte
reversible: true
type: Reaction
is described by: ECO:0000134
product: MODEL1310110002#
is: SBO:0000185
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)

metaR HIStN1
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000185
type: Reaction
is described by: ECO:0000269
product: MODEL1310110002#
reversible: true
modifier: MODEL1310110002#
fast: false
name: Histidine transport (Na, H coupled)

metaM occoa c
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
name: Octanoyl-CoA (n-C8:0CoA)
has only substance units: false
boundary condition: false
is: C01944
is: HMDB01070
constant: false
is: CHEBI:57386
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_1e094830_fcde_4f22_a947_54372e00f59b
initial concentration: NaN
name: _AA977580_1_c
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:AA977580
boundary condition: true
is: SBO:0000252
has only substance units: false

metaR HDCAtr
is described by: ECO:0000000
name: fatty acid transport via diffusion
kinetic law: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reactant: MODEL1310110002#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_f8eb708c_33c9_46ec_a653_714dd62a3148
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
type: Species
is encoded by: hsa:AI480132
name: _AI480132_1_c
initial concentration: NaN
is: SBO:0000252

metaR DGK2m
reactant: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.8 Confidence Level: 2 AUTHORS: NOTES:Added EC- JLR IT
fast: false
name: deoxyguanylate kinase (dGMP:dATP) (mitochondrial)

metaR r2408
is: SBO:0000185
type: Reaction
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_e525f6d9_68c9_4761_858e_0e08c25aa5d0
is: P03905
type: Species
boundary condition: true
initial amount: NaN
name: ND4
is: SBO:0000252
is encoded by: hsa:4538
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_f1038ba9_aae2_4763_9c20_ea3fdd3d5005
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
name: ALDH1A1
is: SBO:0000252
is: P00352
is encoded by: hsa:216

http://identifiers.org/biomodels.db/MODEL1310110002#_211cef2c_3478_462a_9b99_837d5174d6f7
boundary condition: true
name: LDHAL6B
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:92483
is: Q9BYZ2
constant: false

metaR DIDPtn
reversible: true
name: dIDP nuclear transport
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185

metaR r2353
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#

metaR r0722
type: Reaction
kinetic law: MODEL1310110002#
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reactant: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.3.12
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
fast: false
product: MODEL1310110002#
is described by: ECO:0000000

metaR L LACt4r
reactant: MODEL1310110002#
fast: false
product: MODEL1310110002#
reversible: true
type: Reaction
name: L-lactate reversible transport via sodium symport
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8476015,PMID:9425115 NOTES:
is: SBO:0000185
is described by: ECO:0000000

metaM ksii core2 pre4 g
constant: false
notes: FORMULA: C53H86N4O38X CHARGE: -1
type: Species
is: HMDB00175
is: C00130
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 4
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_dd4b55fe_c46d_40d4_9b07_618a2a74ff2d
initial concentration: NaN
has only substance units: false
is: Q04760
name: GLO1
constant: false
is encoded by: hsa:2739
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_9b71b05a_ec20_4d36_9800_7b9ad89dcfeb
is encoded by: hsa:2585
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: GALK2
type: Species

metaR RE1517M
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.3.6
reversible: true
reactant: MODEL1310110002#
type: Reaction
is: SBO:0000176
fast: false
is described by: ECO:0000000
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.99.13
name: RE1517

http://identifiers.org/biomodels.db/MODEL1310110002#_837b0809_9c96_43a3_a8af_b236f525345b
type: Species
boundary condition: true
is: Q02318
constant: false
initial amount: NaN
has only substance units: false
name: CYP27A1
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1593

metaM ksi pre24 g
is: SBO:0000247
boundary condition: false
type: Species
is: HMDB00175
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
has only substance units: false
is: C00130
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 24
initial concentration: 1.0
constant: false
is: CHEBI:58053

metaR PGLer
is described by: ECO:0000269
is: SBO:0000176
name: 6-phosphogluconolactonase, endoplasmic reticulum
reactant: MODEL1310110002#
reversible: false
type: Reaction
modifier: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.47
kinetic law: MODEL1310110002#

metaM 13dpg c
is: HMDB01270
name: 3-Phospho-D-glyceroyl phosphate
type: Species
constant: false
notes: FORMULA: C3H4O10P2 CHARGE: -4 INCHI: 1/C3H8O10P2/c4-2(1-12-14(6,7)8)3(5)13-15(9,10)11/h2,4H,1H2,(H2,6,7,8)(H2,9,10,11)/t2-/m1/s1/f/h6-7,9-10H HEPATONET_1.0_ABBREVIATION: HC00214 EHMN_ABBREVIATION: C00236
boundary condition: false
is: C00236
is: SBO:0000247
has only substance units: false
is: CHEBI:57604
initial concentration: 1.0
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3535

metaM dag hs c
is: CHEBI:18035
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
constant: false
is: SBO:0000247
type: Species
name: diglyceride
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_627d2b46_bbb9_4275_8fc3_430df9bbdf41
has only substance units: false
is encoded by: hsa:5294
boundary condition: true
initial amount: NaN
initial concentration: NaN
name: PIK3CG
type: Species
is: P48736
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_2d9a754a_cc91_46c5_98f2_74f37fdb7332
name: ACADVL
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: P49748
is encoded by: hsa:37

metaM prostge2 e
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
has only substance units: false
boundary condition: false
is: HMDB01220
constant: false
is: SBO:0000247
is: CHEBI:606564
name: prostaglandin E2(1-)
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_6e0d79df_9d82_4853_b5ce_fd530384a552
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:5305
is: P48426
boundary condition: true
constant: false
has only substance units: false
name: PIP4K2A

metaR ABTti
is described by: ECO:0000000
is: SBO:0000185
name: L-arabinitol transport via passive diffusion
reversible: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_617516ca_fe84_4077_8471_5e2e4bc97e8f
has only substance units: false
is encoded by: hsa:8833
is: SBO:0000252
name: GMPS
initial concentration: NaN
is: P49915
type: Species
constant: false
initial amount: NaN
boundary condition: true

metaR PUNP3
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Guanosine)
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
reactant: MODEL1310110002#
type: Reaction
product: MODEL1310110002#

metaM dgdp m
is: CHEBI:58595
initial amount: NaN
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
boundary condition: false
initial concentration: 1.0
constant: false
name: dGDP(2-)
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB00960

metaM pan4p c
initial concentration: 1.0
is: C01134
has only substance units: false
is: HMDB01416
initial amount: NaN
boundary condition: false
type: Species
name: Pantetheine 4'-phosphate
constant: false
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: CHEBI:47942

metaR EX dgmp LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGMP(2-)
type: Reaction

metaM thcholstoic c
is: HMDB03873
type: Species
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: CHEBI:18402
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
boundary condition: false
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaR r0941
fast: false
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:911815 NOTES:
is described by: ECO:0000000
type: Reaction
name: Free diffusion
is: SBO:0000185
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true

metaR S23Tg
kinetic law: MODEL1310110002#
is described by: ECO:0000269
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6482.1) or (6482.2) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:10504389,PMID:8027041 NOTES:NCD
name: beta-galactoside alpha-2,3-sialyltransferase (T antigen)
product: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.4
reactant: MODEL1310110002#
fast: false

metaR r0202
fast: false
name: sn-Glycerol-3-phosphate:NAD+ 2-oxidoreductase Glycerophospholipid metabolism EC:1.1.1.8
reversible: true
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.8 Confidence Level: 0 AUTHORS: PMID:17045662,PMID:7772607 NOTES:
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_7cdd1041_dd91_4135_8d05_0db91e18fc84
is: Q5T4W8
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6487
name: ST3GAL3

metaR ORPT
reversible: true
fast: false
product: MODEL1310110002#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
is: SBO:0000176
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.2.10
name: orotate phosphoribosyltransferase

metaM retfa c
has only substance units: false
initial concentration: 1.0
is: CHEBI:50211
is: HMDB00305
type: Species
is: SBO:0000247
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial amount: NaN
name: fatty acid retinol
constant: false
boundary condition: false

metaM ibcoa m
initial amount: NaN
constant: false
type: Species
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57338
is: SBO:0000247
name: isobutyryl-CoA(4-)
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
is: HMDB01243

metaR DURIPP
kinetic law: MODEL1310110002#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.4.2.3
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
name: deoxyuridine phosphorylase
product: MODEL1310110002#
is: SBO:0000176
reversible: true
fast: false
reactant: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1

metaR STS2
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: false
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
name: Steryl-sulfatase
is version of: http://identifiers.org/ec-code/3.1.6.2
fast: false
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
reactant: MODEL1310110002#
modifier: MODEL1310110002#

metaR r0834
product: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.5.4.16
fast: false

metaR r1257
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
is: SBO:0000176
is described by: ECO:0000000
reversible: false
fast: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
name: EC:6.2.1.3
type: Reaction
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_a74e34c7_8b83_44a6_b05b_c29d9f26dbf6
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:51022
is: SBO:0000252
name: GLRX2

metaR r1106
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110002#
is described by: ECO:0000000
name: Postulated transport reaction
is: SBO:0000185
reactant: MODEL1310110002#
type: Reaction
kinetic law: MODEL1310110002#
fast: false

metaR ST8SIA12
type: Reaction
is: SBO:0000176
reversible: false
modifier: MODEL1310110002#
is described by: ECO:0000000
name: Beta-galactoside alpha-2,3-sialyltransferase
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (6489.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.99.8
kinetic law: MODEL1310110002#
fast: false

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaM gthrd c
has only substance units: false
is: C00051
is: HMDB00125
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:57925
initial amount: NaN
constant: false
name: Reduced glutathione
is: SBO:0000247
notes: FORMULA: C10H16N3O6S CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051

metaM pail35p hs c
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
initial concentration: 1.0
is: CHEBI:57923
constant: false
has only substance units: false
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
is: SBO:0000247
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_d1db23c1_3cc8_4a9f_a3a4_9a25456c4b34
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: _AI631997_1_m
is encoded by: hsa:AI631997
initial amount: NaN
constant: false
type: Species
boundary condition: true

metaR PUNP4
type: Reaction
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
modifier: MODEL1310110002#
is: SBO:0000176
name: purine-nucleoside phosphorylase (Deoxyguanosine)
product: MODEL1310110002#
reversible: true
is described by: ECO:0000269

metaM for c
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15740
is: HMDB00142
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
is: C00058
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
name: Formate

metaR r1512
type: Reaction
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
product: MODEL1310110002#
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#

metaM pep c
is: HMDB00263
has only substance units: false
is: C00074
constant: false
notes: FORMULA: C3H2O6P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00076 EHMN_ABBREVIATION: C00074
initial concentration: 1.0
is: CHEBI:18021
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
name: Phosphoenolpyruvate

http://identifiers.org/biomodels.db/MODEL1310110002#_87382a54_c763_4f0d_aa39_d2a3c9a227d1
has only substance units: false
type: Species
is encoded by: hsa:3038
boundary condition: true
initial concentration: NaN
name: HAS3
initial amount: NaN
is: O00219
is: SBO:0000252
constant: false

metaM icit m
initial amount: NaN
type: Species
is: CHEBI:16087
name: Isocitrate
is: HMDB00193
is: C00311
constant: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_f2449bae_c648_4513_adb6_8fb7a0f68ae0
is: P13686
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:54
initial concentration: NaN
type: Species
name: ACP5
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_18eec28c_4e8b_4bf5_8565_9d761bdef11c
boundary condition: true
is: Q9H2F3
name: HSD3B7
is encoded by: hsa:80270
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaR r0940
reversible: true
is: SBO:0000185
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110002#
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110002#
name: Free diffusion

metaR EX 7dhf LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (DHF) exchange
type: Reaction

metaM dag hs e
constant: false
type: Species
is: CHEBI:18035
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2 CHARGE: 0
name: diglyceride
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_59285fb8_d610_4fe3_8881_dec8b431945e
initial concentration: NaN
name: NMNAT2
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9BZQ4
has only substance units: false
constant: false
is encoded by: hsa:23057
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_d5404fb6_62f7_43df_bdda_902bb1be082e
name: ENTPD5
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:957
type: Species
is: O75356
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_aa24b74c_131d_42dd_a677_8269cd3e275e
is: Q9H3H5
type: Species
initial amount: NaN
is encoded by: hsa:1798
name: DPAGT1
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

metaR ITCOAL1m
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
modifier: MODEL1310110002#
type: Reaction
fast: false
kinetic law: MODEL1310110002#
is described by: ECO:0000304
reactant: MODEL1310110002#
is: SBO:0000176
reversible: true
product: MODEL1310110002#
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
is version of: http://identifiers.org/ec-code/6.2.1.4

http://identifiers.org/biomodels.db/MODEL1310110002#_3fd2beb6_4ecb_42f4_92e3_aa08af7cb6be
has only substance units: false
initial concentration: NaN
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:6531
initial amount: NaN
is: Q01959
name: SLC6A3

metaR r1259
is described by: ECO:0000000
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
name: EC:6.2.1.3
reversible: false
fast: false
is: SBO:0000176
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:

metaM HC01444 e
has only substance units: false
notes: FORMULA: C9H18O8 CHARGE: 0 INCHI: InChI=1S/C9H18O8/c10-1-4(12)3-16-9-8(15)7(14)6(13)5(2-11)17-9/h4-15H,1-3H2/t4-,5-,6+,7+,8-,9-/m1/s1 EHMN_ABBREVIATION: C05401
constant: false
is: CHEBI:15754
initial amount: NaN
is: SBO:0000247
name: Galactosylglycerol
type: Species
boundary condition: false
initial concentration: 1.0

metaR PUNP1
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110002#
name: purine-nucleoside phosphorylase (Adenosine)
fast: false
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110002#
is: SBO:0000176
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true

metaM ksii core2 deg2 l
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: HMDB00143
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
is: SBO:0000247
has only substance units: false
is: CHEBI:12936
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 2

http://identifiers.org/biomodels.db/MODEL1310110002#_e4fe7f46_41da_4229_bb56_4bd929f60bf8
initial amount: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:50808
has only substance units: false
type: Species
name: AK3
is: E7ET30
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_439a9ea6_8157_4620_a388_cc0621860436
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:4728
constant: false
name: NDUFS8
is: O00217

metaM pan4p e
is: HMDB01416
is: C01134
initial amount: NaN
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
constant: false
is: SBO:0000247
name: Pantetheine 4'-phosphate
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: CHEBI:47942

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaM hpyr c
initial amount: NaN
constant: false
has only substance units: false
name: 3-hydroxypyruvate
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB01352
type: Species
is: CHEBI:17180
notes: FORMULA: C3H3O4 CHARGE: -1 INCHI: InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00163 EHMN_ABBREVIATION: C00168

metaM adp m
constant: false
type: Species
is: HMDB01341
is: http://identifiers.org/pubchem.compound/3310
name: ADP
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:456216
has only substance units: false
boundary condition: false
is: C00008

http://identifiers.org/biomodels.db/MODEL1310110002#_7f1e8de2_1c2d_47a5_b110_c6701c455e67
is encoded by: hsa:377841
has only substance units: false
type: Species
is: Q5MY95
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: ENTPD8
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_a920b8a5_aa0a_45a6_88bd_db5c23e0193d
is: P17858
name: PFKL
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5211
boundary condition: true
has only substance units: false

metaR NTD7e
is version of: http://identifiers.org/ec-code/3.1.3.5
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (4907.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:14578500 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000269
reversible: false
fast: false
modifier: MODEL1310110002#
reactant: MODEL1310110002#
name: 5'-nucleotidase (AMP), extracellular

http://identifiers.org/biomodels.db/MODEL1310110002#_cf415f7e_a75f_4eb2_a169_2282205e4fb7
initial concentration: NaN
has only substance units: false
is encoded by: hsa:2582
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: GALE
is: Q14376

http://identifiers.org/biomodels.db/MODEL1310110002#_9d7cf044_62aa_47f7_878b_6abe49197863
type: Species
is: SBO:0000252
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false
name: AMT
initial concentration: NaN
is: P48728
is encoded by: hsa:275

metaM gthrd e
name: glutathionate(1-)
is: HMDB00125
has only substance units: false
type: Species
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57925
constant: false
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_6ac2af69_02a5_408d_91d8_155da136cc96
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
name: _AI285872_1_c
is encoded by: hsa:AI285872
initial concentration: NaN
type: Species
initial amount: NaN

metaR r1318
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110002#
is: SBO:0000185
reversible: true
product: MODEL1310110002#
name: Transport reaction
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110002#

metaR UMPK5n
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.4.14
reversible: true
type: Reaction
name: UMP kinase (dATP),nuclear
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_cf4bdcb0_34ff_49bf_af60_15988beb29ca
name: PLCD1
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is: P51178
is encoded by: hsa:5333
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_fucfucgalacglcgalacglcgal14acglcgalgluside_hs_g
has only substance units: false
type: Species
boundary condition: false
is: CHEBI:61648
notes: FORMULA: C84H145N4O50FULLRCO CHARGE: 0
initial concentration: 1.0
initial amount: NaN
constant: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1
is: SBO:0000247

metaM adp n
boundary condition: false
is: HMDB01341
constant: false
is: CHEBI:456216
initial concentration: 1.0
name: ADP(3-)
has only substance units: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00018 EHMN_ABBREVIATION: C00008
type: Species
initial amount: NaN
is: SBO:0000247

metaM for e
is: CHEBI:15740
is: HMDB00142
initial concentration: 1.0
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: formate
type: Species

metaM ptth m
initial amount: NaN
name: pantetheine
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
constant: false
is: HMDB03426
has only substance units: false
is: CHEBI:16753
notes: FORMULA: C11H22N2O4S CHARGE: 0 INCHI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00554 EHMN_ABBREVIATION: C00831

metaR PUNP2
kinetic law: MODEL1310110002#
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.1
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
fast: false
name: purine-nucleoside phosphorylase (Deoxyadenosine)
reactant: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
reversible: true

metaR r0002
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110002#
name: Active transport
is: SBO:0000185

metaR r0942
reversible: true
is: SBO:0000185
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.4
is described by: ECO:0000000
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11165387,PMID:12110547,PMID:12145274,PMID:15918910,PMID:3896131,PMID:9386672 NOTES:

metaM gluside hs r
constant: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:18368
name: D-glucosyl-N-acylsphingosine
initial amount: NaN

metaM pail5p hs c
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
is: CHEBI:57795
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)

http://identifiers.org/biomodels.db/MODEL1310110002#_135dd766_cb74_402f_9afd_fc13173f059b
has only substance units: false
boundary condition: true
is: O94788
is: SBO:0000252
is encoded by: hsa:8854
type: Species
name: ALDH1A2
constant: false
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_e58340e5_bff8_47d1_99c0_1529475a7beb
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:53354
is: SBO:0000252
name: PANK1
constant: false
boundary condition: true

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaR PUNP7
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
fast: false
reactant: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000269
is: SBO:0000176
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
modifier: MODEL1310110002#
name: purine-nucleoside phosphorylase (Xanthosine)
type: Reaction
kinetic law: MODEL1310110002#

metaM pail45p hs n
type: Species
has only substance units: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: CHEBI:28910
boundary condition: false
name: phosphatidylinositol 4,5-bisphosphate
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247

metaM didp c
boundary condition: false
initial amount: NaN
is: CHEBI:28823
constant: false
initial concentration: 1.0
name: dIDP
is: SBO:0000247
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
type: Species
is: HMDB03536
has only substance units: false

metaR r0830
notes: GENE_ASSOCIATION: (2643.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reactant: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.16
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110002#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.2

metaR r2358
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_ed5d20af_e83a_43bd_a251_ab4608057836
has only substance units: false
is encoded by: hsa:AI539321
type: Species
is: SBO:0000252
initial concentration: NaN
name: _AI539321_1_c
constant: false
initial amount: NaN
boundary condition: true

metaR FATP2t
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
name: fatty acid electroneutral transport
fast: false
is: SBO:0000185
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
is described by: ECO:0000269

metaM betald m
constant: false
type: Species
boundary condition: false
name: betaine aldehyde
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01252
is: CHEBI:15710
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: SBO:0000247

metaR r0086
reactant: MODEL1310110002#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (56954.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.5.1.3
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
modifier: MODEL1310110002#
reversible: false

metaR GLYSNAT5tc
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Glycine into the cell coupled with co-transport with Sodium and counter transport with proton by SNAT5 transporter.
type: Reaction

metaR PCm
reactant: MODEL1310110002#
type: Reaction
is described by: ECO:0000269
name: pyruvate carboxylase
is: SBO:0000176
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance
fast: false
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/6.4.1.1
reversible: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#

metaM dpcoa m
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
is: CHEBI:57328
initial amount: NaN
initial concentration: 1.0
name: 3'-dephospho-CoA(2-)
is: HMDB01373
constant: false
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species

metaR GLUDym
is described by: ECO:0000269
name: glutamate dehydrogenase (NADP), mitochondrial
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.4.1.3
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
is: SBO:0000176
type: Reaction

metaM ksi pre35 g
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 35
is: SBO:0000247
constant: false
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110002#_326cdf11_1885_4ec6_afa9_31ba590e1eed
is: SBO:0000252
name: ITPKA
is: P23677
boundary condition: true
is encoded by: hsa:3706
type: Species
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false

metaM asp D x
name: D-aspartate(1-)
boundary condition: false
is: CHEBI:29990
initial concentration: 1.0
notes: FORMULA: C4H6NO4 CHARGE: -1 INCHI: InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/p-1/t2-/m1/s1
is: SBO:0000247
initial amount: NaN
is: HMDB06483
constant: false
has only substance units: false
type: Species

metaR r2359
name: Organic anion transporter 5 Utilized transport
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110002#
is: SBO:0000185

metaR UAGDP
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.7.23
modifier: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
type: Reaction
name: UDP-N-acetylglucosamine diphosphorylase
reversible: false
fast: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.7.23 Confidence Level: 4 AUTHORS: PMID:9603950 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110002#_3d099c23_7b57_40a2_8c55_a9c5004d844b
name: ECH1
type: Species
initial amount: NaN
is: Q13011
has only substance units: false
is encoded by: hsa:1891
constant: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_04b2196c_1634_43b1_9955_a31bbae089ba
initial amount: NaN
name: COX7A2L
has only substance units: false
constant: false
is encoded by: hsa:9167
type: Species
is: Q6FGA0
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR r0085
name: 2-Oxoglutaramate amidohydrolase Glutamate metabolism EC:3.5.1.3
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.42
product: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Urea cycle EC Number: 3.5.1.3 Confidence Level: 0 AUTHORS: PMID:3003502,PMID:319948,PMID:4436326,PMID:5114531,PMID:894284 NOTES:
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_891e2796_d093_4d32_9ccb_ea87c5c4199c
initial concentration: NaN
is encoded by: hsa:10861
has only substance units: false
constant: false
boundary condition: true
name: SLC26A1
type: Species
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_28669cb0_4d51_47bd_81f3_7914fe476747
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:43
name: ACHE
type: Species
boundary condition: true
initial amount: NaN

metaM glc D e
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: HMDB00122
type: Species
boundary condition: false
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
constant: false
initial amount: NaN
is: CHEBI:4167

http://identifiers.org/biomodels.db/MODEL1310110002#_ed90f6a3_3c38_45a0_9579_c7afb4dcda6c
is: SBO:0000252
constant: false
name: COX6B2
initial concentration: NaN
initial amount: NaN
type: Species
is: Q6YFQ2
is encoded by: hsa:125965
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_5f41faf1_70ea_4037_b97f_f83e6bdc5bbf
name: NT5M
is: Q9NPB1
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:56953
constant: false
boundary condition: true
initial amount: NaN

metaM 5fthf m
initial amount: NaN
name: 5-formyltetrahydrofolate(2-)
is: CHEBI:57457
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/p-2/t12-,13-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01125 EHMN_ABBREVIATION: C03479
boundary condition: false
is: HMDB01562
constant: false

metaR r0208
fast: false
type: Reaction
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/4.4.1.1
kinetic law: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1491.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.13 Confidence Level: 0 AUTHORS: PMID:10025667,PMID:8549746,PMID:9451026 NOTES:
reactant: MODEL1310110002#
reversible: true
is: SBO:0000176
modifier: MODEL1310110002#
name: GTP:alpha-D-mannose-1-phosphate guanylyltransferase Fructose and mannose metabolism EC:2.7.7.13

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM itp e
is: SBO:0000247
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
is: CHEBI:57614
constant: false
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00189
name: ITP(3-)
initial concentration: 1.0
boundary condition: false

metaR INSTt2r
fast: false
is: SBO:0000185
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#
reversible: true
name: inositol transport in via proton symport
notes: GENE_ASSOCIATION: (114134.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11500374,PMID:12750891 NOTES:
modifier: MODEL1310110002#
type: Reaction
is described by: ECO:0000269

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaR B3GNT33g
is: SBO:0000176
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
reversible: false
type: Reaction
is described by: ECO:0000269
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reactant: MODEL1310110002#
product: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM ksi pre17 g
name: keratan sulfate I biosynthesis, precursor 17
initial concentration: 1.0
is: CHEBI:28067
notes: FORMULA: C157H252N11O127S5X CHARGE: -6
boundary condition: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
has only substance units: false

metaM cytd m
is: HMDB00089
has only substance units: false
initial amount: NaN
is: CHEBI:17562
type: Species
initial concentration: 1.0
notes: FORMULA: C9H13N3O5 CHARGE: 0 INCHI: InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00381 EHMN_ABBREVIATION: C00475
is: SBO:0000247
constant: false
boundary condition: false
name: cytidine

metaR S6T15g
fast: false
type: Reaction
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.8.2.21
reversible: false
is described by: ECO:0000000
modifier: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.8.2.17
reactant: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#

metaR r0618
is: SBO:0000176
reversible: true
fast: false
kinetic law: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
type: Reaction
name: trans-4-Hydroxy-L-proline:NADP+ 5-oxidoreductase Arginine and proline metabolism EC:1.5.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 0 AUTHORS: PMID:12514185,PMID:3768405,PMID:6250440,PMID:675382 NOTES:
product: MODEL1310110002#

metaR AG13T15g
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
reversible: false
modifier: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110002#_24a0ce20_a06e_4da6_a0c4_b63b1b9b300b
is: Q9H845
name: ACAD9
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:28976

metaR RE0453N
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
fast: false
reversible: true
product: MODEL1310110002#
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110002#
name: RE0453
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM clpn hs c
constant: false
initial amount: NaN
is: HMDB00156
boundary condition: false
name: clpn_hs[c]
has only substance units: false
is: CHEBI:15589
type: Species
is: SBO:0000247
notes: FORMULA: CHARGE: 0
initial concentration: 1.0

metaM 4hexdtricoa m
type: Species
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
name: 4,7,10-hexadecatrienoylcoa
has only substance units: false
is: HMDB02288
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR G12MT2 U
reversible: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
reactant: MODEL1310110002#
fast: false

metaM CE4876 r
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: CHEBI:57923
constant: false
name: delta12-Prostaglandin J2
type: Species
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1/C20H30O4/c1-2-3-6-10-17(21)13-14-18-16(12-15-19(18)22)9-7-4-5-8-11-20(23)24/h4,7,12,14-17,21H,2-3,5-6,8-11,13H2,1H3,(H,23,24)/p-1/b7-4-,18-14+/t16-,17-/m0/s1 EHMN_ABBREVIATION: CE4876
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_dbae8f67_c2d9_472a_97bb_69c69a7d0f24
is encoded by: hsa:AA419122
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
name: _AA419122_1_c
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_6c511dda_a3f8_4168_ac85_2127fd163e80
initial concentration: NaN
name: SLC16A1
type: Species
is encoded by: hsa:6566
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is: B4DKS0
constant: false

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_359d3de2_3c5b_41ba_963d_2ba85fea09d2
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: Q9Y2D0
is encoded by: hsa:11238
constant: false
has only substance units: false
name: CA5B

metaR RE3269C
fast: false
product: MODEL1310110002#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.1.3.48
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.1.3.66 Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:Recin 1 had irreversible version - PI35P3P - GPR from PI35P3P was added - May 2011 IT
is described by: ECO:0000000
reactant: MODEL1310110002#
name: RE3269
type: Reaction

metaR TPI
reversible: true
reactant: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/5.3.1.1
name: triose-phosphate isomerase
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
is: SBO:0000176
is described by: ECO:0000134
fast: false
product: MODEL1310110002#
kinetic law: MODEL1310110002#

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaR PUNP6
type: Reaction
reactant: MODEL1310110002#
product: MODEL1310110002#
name: purine-nucleoside phosphorylase (Deoxyinosine)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.1
reversible: true
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_a8b54180_7e2e_491e_8dcf_4c270acdc14e
constant: false
is: Q9Y6M9
boundary condition: true
name: NDUFB9
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4715
type: Species
has only substance units: false

metaM dgdp n
is: HMDB00960
boundary condition: false
name: dGDP(2-)
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C10H12N5O10P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O10P2/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(24-6)2-23-27(21,22)25-26(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H2,18,19,20)(H3,11,13,14,17)/p-3/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00305 EHMN_ABBREVIATION: C00361
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:58595

http://identifiers.org/biomodels.db/MODEL1310110002#_5aba746d_0ea0_4054_8830_e102436572fd
is encoded by: hsa:9856
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: F5H123
type: Species
boundary condition: true
name: DYLX2
constant: false
initial amount: NaN

metaM glyc e
constant: false
initial concentration: 1.0
type: Species
is: C00116
is: HMDB00131
is: CHEBI:17754
has only substance units: false
name: Glycerol
initial amount: NaN
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
is: SBO:0000247
boundary condition: false

metaM man6p c
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
is: HMDB01078
initial concentration: 1.0
name: D-Mannose 6-phosphate
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:17369

metaR r0083
product: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
name: Oxalosuccinate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.42
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:16489927,PMID:9866202 NOTES:

metaR PRASCS
product: MODEL1310110002#
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (10606.1) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is: SBO:0000176
fast: false
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/6.3.2.6
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase

metaM 10fthf c
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
initial amount: NaN
initial concentration: 1.0
type: Species
name: 10-Formyltetrahydrofolate
constant: false
is: HMDB00972
boundary condition: false
is: CHEBI:57454
is: SBO:0000247
has only substance units: false
is: C00234

metaR CYANt
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:assumed to be readily diffusible MM
product: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
fast: false
name: Cyanide transport via diffusion (extracellular to cytosol)
kinetic law: MODEL1310110002#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_b425016b_0938_4cdd_966e_330439e33b27
name: DGUOK
constant: false
has only substance units: false
is encoded by: hsa:1716
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN

metaR EX thf LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange
type: Reaction

metaM glc D c
is: CHEBI:4167
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB00122
name: D-glucose
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_b9ab04f3_f4f6_457c_bb34_f812ab52afea
has only substance units: false
is: E5KNH5
name: NDUFV1
constant: false
boundary condition: true
is encoded by: hsa:4723
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaR RE0453M
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110002#
name: RE0453
is: SBO:0000176
reversible: true
modifier: MODEL1310110002#

metaR SO4HCOtex
type: Reaction
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (115111.1) or (115019.2) or (1836.1) or (115111.2) or (116369.2) or (284129.1) or (10861.2) or (116369.1) or (10861.1) or (10861.3) or (115019.1) or (1811.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
is described by: ECO:0000304
modifier: MODEL1310110002#
is: SBO:0000185
kinetic law: MODEL1310110002#
name: sulfate transport via bicarbonate countertransport
reversible: false
product: MODEL1310110002#

metaM ocdca c
name: stearate
initial amount: NaN
constant: false
is: HMDB00827
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
initial concentration: 1.0
is: CHEBI:25629

metaR RE1531M
is: SBO:0000176
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
name: RE1531
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
fast: false
modifier: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110002#_437590bf_1552_4741_b950_b8c22f14f7b1
constant: false
has only substance units: false
type: Species
name: CCBL1
is encoded by: hsa:883
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: Q16773
initial concentration: NaN

metaR RE2659R
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#
name: RE2659
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110002#
fast: false
type: Reaction

metaM ksii core2 pre9 g
initial concentration: 1.0
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
type: Species
boundary condition: false
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 9
has only substance units: false
is: CHEBI:28067
is: SBO:0000247
constant: false

metaM m6masnC g
constant: false
is: HMDB01356
initial concentration: 1.0
initial amount: NaN
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
is: CHEBI:57312
notes: FORMULA: C58H97N2O45X CHARGE: 0
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_a1f99cf9_d7cc_4756_bd04_253da8ea33ad
has only substance units: false
initial amount: NaN
name: TPH1
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:7166
boundary condition: true
type: Species
is: P17752
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_dd9d1ab0_9f38_4feb_8b77_f83743286b96
initial concentration: NaN
constant: false
is encoded by: hsa:55808
type: Species
has only substance units: false
initial amount: NaN
is: Q9NSC7
name: ST6GALNAC1
is: SBO:0000252
boundary condition: true

metaM cspg d e
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H64N2O51S5X CHARGE: -7
type: Species
boundary condition: false
is: HMDB00630
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16040
constant: false
name: chondroitin sulfate D (GlcNAc6S-GlcA2S) proteoglycan

metaR GGH 5DHFe
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) - last step from 5-glutamyl to monoglutamyl is in one step IT
reactant: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110002#
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (5DHF), extracellular
modifier: MODEL1310110002#
fast: false
reversible: false

metaM dadp c
initial concentration: 1.0
notes: FORMULA: C10H12N5O9P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00192 EHMN_ABBREVIATION: C00206
initial amount: NaN
is: CHEBI:57667
name: dADP
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB01508
is: C00206
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_78ab39db_7d44_4ff6_b55a_c344ff8013cb
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4697
constant: false
boundary condition: true
initial concentration: NaN
is: O00483
name: NDUFA4
has only substance units: false
type: Species

metaM 5adtststerones c
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB06278
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
name: 5alpha-Dihydrotestosterone sulfate
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_905a8d27_9772_47f2_ac0f_7353a6a80316
is encoded by: hsa:4700
name: NDUFA6
type: Species
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is: P56556

http://identifiers.org/biomodels.db/MODEL1310110002#_de66c563_f8b5_4471_8940_7540e367624d
is encoded by: hsa:130
type: Species
is: P28332
initial concentration: NaN
boundary condition: true
constant: false
name: ADH6
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaM ksii core2 pre1 g
initial amount: NaN
type: Species
name: keratan sulfate II biosynthesis, precursor 1
constant: false
notes: FORMULA: C33H53N3O23X CHARGE: -1
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:28067

metaR ADK3m
kinetic law: MODEL1310110002#
is described by: ECO:0000269
modifier: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
type: Reaction
reactant: MODEL1310110002#
name: adentylate kinase (GTP)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.10
product: MODEL1310110002#
reversible: true

metaM amp x
is: CHEBI:456215
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
is: HMDB00045
initial concentration: 1.0
name: AMP
has only substance units: false
is: C00020
boundary condition: false

metaR CYTK13n
is described by: ECO:0000269
is: SBO:0000176
reversible: true
type: Reaction
reactant: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.4.14
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dATP),nuclear
product: MODEL1310110002#

metaR PAIL4P HStn
reactant: MODEL1310110002#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110002#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)
product: MODEL1310110002#

metaR GMAND
modifier: MODEL1310110002#
type: Reaction
name: GDP-D-mannose dehydratase
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/4.2.1.47
is described by: ECO:0000000
product: MODEL1310110002#
reversible: false
notes: GENE_ASSOCIATION: (2762.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 4.2.1.47 Confidence Level: 0 AUTHORS: NOTES:JLR
reactant: MODEL1310110002#
is: SBO:0000176
fast: false

metaR RBTt
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
type: Reaction
is: SBO:0000185
name: ribitol transport via passive diffusion
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
is described by: ECO:0000000
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_04cb2d0a_5e20_498f_bf13_1d241aa03e42
name: CHST5
is encoded by: hsa:23563
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q9GZS9
initial concentration: NaN
has only substance units: false
type: Species
constant: false

metaR LNLCCPT2
reactant: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction

metaR PTPATe
is described by: ECO:0000134
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
name: PTPATe
type: Reaction
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_4f778e6b_4c43_4e92_b7d6_cb5e2d130f65
initial amount: NaN
type: Species
is encoded by: hsa:5167
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P22413
name: ENPP1
boundary condition: true
constant: false

metaR EX dtmp LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dTMP(2-)
type: Reaction

metaR DCMPDA
fast: false
notes: GENE_ASSOCIATION: (1635.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.12 Confidence Level: 2 AUTHORS: PMID:7642519,PMID:7685356 NOTES:NCD
type: Reaction
modifier: MODEL1310110002#
name: dCMP deaminase
product: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.5.4.12
is: SBO:0000176
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110002#_ea58506a_bf42_43aa_a533_fb93b003af16
is: SBO:0000252
is encoded by: hsa:1716
boundary condition: true
constant: false
name: DGUOK
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_81985961_e783_410f_98a6_242c8b3c674a
initial concentration: NaN
is: Q9H2B4
initial amount: NaN
boundary condition: true
constant: false
type: Species
is encoded by: hsa:10861
has only substance units: false
is: SBO:0000252
name: SLC26A1

metaR ASPTA
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
reactant: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
name: aspartate transaminase
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
product: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110002#_77489a73_7192_4399_881f_add57b5d6cee
type: Species
constant: false
is: SBO:0000252
name: NT5E
is: P21589
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:4907

http://identifiers.org/biomodels.db/MODEL1310110002#_da3ef4c3_bd5c_436d_8121_9347b72a60b4
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q15102
constant: false
name: PAFAH1B3
boundary condition: true
has only substance units: false
is encoded by: hsa:5050

metaM ptrc c
boundary condition: false
initial amount: NaN
has only substance units: false
type: Species
constant: false
is: C00134
is: SBO:0000247
is: HMDB01414
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
is: CHEBI:326268
initial concentration: 1.0
name: Putrescine

metaR r1154
product: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 1.2.7.2 Confidence Level: 0 AUTHORS: PMID:2649080,PMID:283398,PMID:3718468,PMID:9381974 NOTES:
name: EC:1.2.7.2
reactant: MODEL1310110002#
fast: false
reversible: true
is described by: ECO:0000000
is: SBO:0000176

metaM CE5121 m
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h9-10,18-20,24-26,30,41-42H,4-8,11-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b10-9+/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE5121
name: trans-3-decenoyl-CoA
type: Species
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:57449
initial amount: NaN

metaR NDPK8n
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000304
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
reactant: MODEL1310110002#
modifier: MODEL1310110002#
name: nucleoside-diphosphate kinase (ATP:dADP), nuclear
reversible: true

metaR EX C05965 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 12(S)-HPETE(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_4846aa68_c945_43fc_a63d_685357b4cdc1
type: Species
constant: false
is: O43181
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4724
initial concentration: NaN
name: NDUFS4
initial amount: NaN

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

metaM ocdca e
has only substance units: false
boundary condition: false
is: HMDB00827
constant: false
is: SBO:0000247
name: octadecanoate (n-C18:0)
initial amount: NaN
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
initial concentration: 1.0
type: Species
is: CHEBI:25629
is: C01530

metaR LDH D
is described by: ECO:0000304
fast: false
type: Reaction
modifier: MODEL1310110002#
is: SBO:0000176
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.2.4
reversible: true
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)
reactant: MODEL1310110002#
name: D-lactate dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110002#_68dfc9c6_7c9e_47e9_b338_e0ab5806bcc2
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:386757
initial amount: NaN
constant: false
type: Species
has only substance units: false
name: SLC6A10P

metaM m2mn l
notes: FORMULA: C26H45NO21 CHARGE: 0 INCHI: InChI=1/C26H45NO21/c1-6(32)27-11-15(36)20(10(5-31)42-23(11)41)46-25-18(39)22(14(35)8(3-29)44-25)48-26-19(40)21(13(34)9(4-30)45-26)47-24-17(38)16(37)12(33)7(2-28)43-24/h7-26,28-31,33-41H,2-5H2,1H3,(H,27,32)/t7-,8-,9-,10+,11+,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24-,25+,26+/m0/s1
is: HMDB06537
initial concentration: 1.0
name: (alpha-D-mannosyl)2-beta-D-mannosyl-N-acetylglucosamine
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false

metaM xyl D c
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: CHEBI:15936
initial concentration: 1.0
type: Species
name: aldehydo-D-xylose
is: SBO:0000247
boundary condition: false

metaR LNLCCPT1
fast: false
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
reversible: false
name: carnitine O-palmitoyltransferase
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110002#_6bb927cf_b78f_4450_a226_24e3d3647865
has only substance units: false
is encoded by: hsa:79053
initial concentration: NaN
name: ALG8
type: Species
is: SBO:0000252
is: Q9BVK2
boundary condition: true
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_4256346c_f049_45a3_a001_b9a38389c357
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI090874
constant: false
name: _AI090874_1_c

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaM so4 e
is: CHEBI:16189
name: sulfate
type: Species
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false
is: HMDB01448
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN

metaR r0647
reactant: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:18124509,PMID:6027578 NOTES:
is: SBO:0000176
name: Spontaneous reaction
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110002#
reversible: true

metaR THRGLNexR
name: L-threonine/glycine reversible exchange
modifier: MODEL1310110002#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110002#
reversible: true
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000304
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_3d2efc64_8445_4087_83b0_591455d1e6fe
has only substance units: false
is encoded by: hsa:23475
boundary condition: true
constant: false
is: Q15274
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: QPRT

http://identifiers.org/biomodels.db/MODEL1310110002#_b1612942_d362_48b8_b6a4_52fdcab58bdd
name: PKM2
initial amount: NaN
is: B4DNK4
type: Species
constant: false
is encoded by: hsa:5315
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR LEUKTRF4t
name: leukotriene F4 transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reactant: MODEL1310110002#
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#

metaM gar c
initial amount: NaN
is: SBO:0000247
is: HMDB02022
boundary condition: false
notes: FORMULA: C7H14N2O8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01190 EHMN_ABBREVIATION: C03838
is: C03838
name: N1-(5-Phospho-D-ribosyl)glycinamide
is: CHEBI:58457
has only substance units: false
type: Species
initial concentration: 1.0
constant: false

metaR ECOAH9m
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
type: Reaction
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
kinetic law: MODEL1310110002#
fast: false
product: MODEL1310110002#

metaM l2n2m2mn l
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)
has only substance units: false
type: Species
notes: FORMULA: C54H91N3O41 CHARGE: 0
is: SBO:0000247
is: HMDB00143
boundary condition: false
initial concentration: 1.0
is: CHEBI:12936
constant: false
initial amount: NaN

metaR HYXNt
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
fast: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110002#
modifier: MODEL1310110002#
name: Hypoxanthine transport
is: SBO:0000185

metaM ile L m
is: CHEBI:17191
is: SBO:0000247
boundary condition: false
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
name: L-isoleucine
is: HMDB00172
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_78cde8c6_6dc9_497b_a309_6b74e942385d
name: NDUFC2
is: Q549M5
initial amount: NaN
has only substance units: false
is encoded by: hsa:4718
constant: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaM Lkynr c
name: L-kynurenine
constant: false
boundary condition: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328
is: CHEBI:16946
is: HMDB00684
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0

metaM ptrc e
is: CHEBI:326268
is: C00134
is: HMDB01414
constant: false
boundary condition: false
type: Species
name: Putrescine
is: SBO:0000247
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_ca20545a_4583_42ed_b580_2434751b0e33
name: PANK4
is: Q9NVE7
is encoded by: hsa:55229
initial amount: NaN
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species

metaM gam6p c
name: D-Glucosamine 6-phosphate
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB01254
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
type: Species
is: CHEBI:12962

http://identifiers.org/biomodels.db/MODEL1310110002#_40b521d8_6cc6_4038_85c3_15218b1d5171
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8972
is: O43451
type: Species
initial amount: NaN
constant: false
name: MGAM

metaR r1744
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_b9760e01_7909_4b04_ab10_c7d25b0e23e8
initial concentration: NaN
name: NAE1
is: A8MU28
is encoded by: hsa:8883
is: SBO:0000252
has only substance units: false
initial amount: NaN
constant: false
type: Species
boundary condition: true

metaR S6T8g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110002#
is: SBO:0000176
fast: false
product: MODEL1310110002#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110002#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_9961197e_4043_4b60_9c91_e670f6e0d757
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: GCAT
is encoded by: hsa:23464
is: E2QC23
type: Species
constant: false

metaR q10tm
type: Reaction
is described by: ECO:0000134
reversible: true
product: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000185
kinetic law: MODEL1310110002#
fast: false
name: transport of ubiquinone into mitochondria
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR SPHK21c
reversible: false
name: sphingosine kinase 2
kinetic law: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
is: SBO:0000176
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.1.91
modifier: MODEL1310110002#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_c04aeb64_d984_446a_8a51_5cfecc506fbf
is encoded by: hsa:10195
constant: false
has only substance units: false
initial concentration: NaN
is: Q92685
boundary condition: true
is: SBO:0000252
initial amount: NaN
name: ALG3
type: Species

metaR AG13T4g
is described by: ECO:0000000
kinetic law: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
fast: false
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.149
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reactant: MODEL1310110002#
reversible: false

metaM m1mpdol U c
initial concentration: 1.0
type: Species
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:28067
initial amount: NaN
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false

metaR r2532
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
reactant: MODEL1310110002#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_8c4e186b_8728_427f_acbc_11969a5e12f2
initial amount: NaN
is: P14854
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:1340
is: SBO:0000252
constant: false
name: COX6B1
boundary condition: true

metaM so4 c
constant: false
initial amount: NaN
name: sulfate
is: CHEBI:16189
boundary condition: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448
is: SBO:0000247
type: Species

metaR G14T17g
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
modifier: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
type: Reaction
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.22
reactant: MODEL1310110002#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_6fec13ff_a1ba_471a_bb0d_26ba0d380cdd
initial concentration: NaN
type: Species
is: SBO:0000297
initial amount: NaN
name: LDHA:LDHB
is encoded by: hsa:3945
constant: false
boundary condition: true
has only substance units: false
has part: P00338
has part: P07195
is encoded by: hsa:3939

metaR FAOXC204
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110002#
type: Reaction
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR CITtam
name: citrate transport, mitochondrial
type: Reaction
product: MODEL1310110002#
modifier: MODEL1310110002#
reversible: true
fast: false
is described by: ECO:0000269
reactant: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
kinetic law: MODEL1310110002#

metaR HISCAT1
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaM gtp m
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP
constant: false
type: Species
initial amount: NaN
is: HMDB01273
is: SBO:0000247
has only substance units: false
is: C00044
is: CHEBI:37565

metaM xyl D e
initial amount: NaN
constant: false
is: CHEBI:15936
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
name: aldehydo-D-xylose
initial concentration: 1.0
is: SBO:0000247

metaM lnlnca r
type: Species
is: HMDB01388
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: alpha-linolenate
is: CHEBI:32387
constant: false
is: SBO:0000247
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427

metaR G14T9g
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
kinetic law: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38
is: SBO:0000176
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
reversible: false
fast: false

metaR EX citr L LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-citrulline exchange
type: Reaction

metaR EX din LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyinosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_5f8b3885_6639_48e4_87bf_61e4b1d07881
has only substance units: false
name: ALG3
boundary condition: true
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:10195
constant: false

metaR FAOXC164GC163m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)gm
type: Reaction

metaR S6T13g
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110002#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
modifier: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
is: SBO:0000176
reversible: false
reactant: MODEL1310110002#
fast: false
is described by: ECO:0000000

metaR NDPK10
is: SBO:0000176
fast: false
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.4.6
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
reversible: true
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dIDP)
reactant: MODEL1310110002#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.

metaM ppi e
is: C00013
initial amount: NaN
type: Species
is: CHEBI:33019
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
boundary condition: false
is: HMDB00250
constant: false
has only substance units: false
name: Diphosphate
initial concentration: 1.0
is: SBO:0000247

metaM mal L e
has only substance units: false
name: (S)-malate(2-)
is: HMDB00156
is: SBO:0000247
is: CHEBI:15589
initial amount: NaN
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_cfa85ef7_a2d6_4342_8a3c_891daa82fd26
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:51109
initial concentration: NaN
name: RDH11
is: B4DDW0

http://identifiers.org/biomodels.db/MODEL1310110002#_df9c8eee_d633_4f5e_bdd3_86fd2134431a
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI769281
is: SBO:0000252
constant: false
type: Species
name: _AI769281_1_e
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_91b9d3ab_18fe_4015_bee4_28b8329e8731
initial concentration: NaN
is: SBO:0000252
is: Q59EH3
name: ACP1
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:52
initial amount: NaN
type: Species

metaM gtp n
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
boundary condition: false
constant: false
is: CHEBI:37565
type: Species
name: GTP(4-)
initial amount: NaN
is: HMDB01273
is: SBO:0000247

metaM glyc R m
is: HMDB00139
boundary condition: false
constant: false
is: CHEBI:16659
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: D-glycerate
has only substance units: false
type: Species
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235

metaR r0360
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110002#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reversible: false
type: Reaction
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/6.2.1.16

metaM retinol cis 11 c
has only substance units: false
name: 11-cis-retinol
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: CHEBI:16302
is: HMDB06216
initial amount: NaN

metaM fn2m2masn g
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
is: CHEBI:32984
is: SBO:0000247
boundary condition: false
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_34bf05a0_29ef_444e_a8a3_db934e6fd3e0
is encoded by: hsa:8897
is: SBO:0000252
initial concentration: NaN
constant: false
name: MTMR3
type: Species
boundary condition: true
initial amount: NaN
is: Q13615
has only substance units: false

metaR NADtpu
reversible: false
type: Reaction
is described by: ECO:0000000
fast: false
product: MODEL1310110002#
is: SBO:0000185
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into peroxisome (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110002#
name: NAD transporter, peroxisome

metaM HC01231 c
is: CHEBI:58480
initial concentration: 1.0
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: SBO:0000247
name: N-[(R)-pantothenoyl]-L-cysteinate
constant: false
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false

metaR RETFA
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
name: retinol acyltransferase
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
reversible: false
fast: false
is described by: ECO:0000000

metaR r2534
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

metaR INSTt4
type: Reaction
reactant: MODEL1310110002#
is described by: ECO:0000269
product: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
modifier: MODEL1310110002#
fast: false
is: SBO:0000185
name: inositol transport via sodium symport

metaR r0936
name: Transport reaction
kinetic law: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110002#
fast: false
reversible: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185

metaM 5adtststerones e
has only substance units: false
is: SBO:0000247
name: 5alpha-Dihydrotestosterone sulfate
notes: FORMULA: C19H29O5S CHARGE: -1 INCHI: InChI=1/C19H30O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12,14-17H,3-11H2,1-2H3,(H,21,22,23)/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: CE6032
type: Species
initial amount: NaN
initial concentration: 1.0
is: HMDB06278
constant: false
boundary condition: false

metaR S2L2N2M2MASNtly
name: s2l2n2m2masn transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110002#
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110002#_5f5b8364_7f47_4d73_9d0e_94bf5f571f91
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
name: MTMR3
is encoded by: hsa:8897

metaM amp r
constant: false
is: C00020
has only substance units: false
name: AMP
initial amount: NaN
is: CHEBI:456215
type: Species
boundary condition: false
initial concentration: 1.0
is: HMDB00045
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020

http://identifiers.org/biomodels.db/MODEL1310110002#_d912b7be_95fb_4093_9023_d120b91e1b58
is encoded by: hsa:3099
name: HK2
initial amount: NaN
constant: false
is: SBO:0000252
is: P52789
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

metaR r2535
is described by: ECO:0000000
product: MODEL1310110002#
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false

metaM 44mzym r
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108
name: 14-demethyllanosterol
is: HMDB01286
is: CHEBI:18364
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR DNDPt22m
kinetic law: MODEL1310110002#
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110002#
is described by: ECO:0000269
reactant: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
reversible: false
fast: false
name: dTDP transport via dUDP antiport

metaM mal L c
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
is: HMDB00156
is: CHEBI:15589
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: (S)-malate(2-)
initial concentration: 1.0

metaM ppi c
is: SBO:0000247
is: C00013
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
name: Diphosphate
initial concentration: 1.0
is: HMDB00250
constant: false
is: CHEBI:0
notes: FORMULA: HO7P2 CHARGE: -3

metaR r1156
fast: false
reactant: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.48 Confidence Level: 0 AUTHORS: PMID:11306702,PMID:11494055,PMID:64250,PMID:9923963 NOTES:
reversible: true
name: dUTP:uridine 5-phosphotransferase Pyrimidine metabolism EC:2.7.1.48
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000176

metaR r0937
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
name: Transport reaction
kinetic law: MODEL1310110002#
is: SBO:0000185
fast: false
reactant: MODEL1310110002#
product: MODEL1310110002#

metaR AG13T16g
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.149
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10678.2) or (10331.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110002#
product: MODEL1310110002#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction
reversible: false
reactant: MODEL1310110002#
is described by: ECO:0000000
fast: false
is: SBO:0000176

metaR FAOXC80
product: MODEL1310110002#
name: Beta oxidation of med/long chain fatty acid
is described by: ECO:0000269
reactant: MODEL1310110002#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_efebf747_fbf0_48b9_a06b_7f08977ab429
boundary condition: true
constant: false
is: SBO:0000252
is: P06132
initial concentration: NaN
is encoded by: hsa:7389
name: UROD
initial amount: NaN
has only substance units: false
type: Species

metaR GALNTg
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
reversible: false
modifier: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
product: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.41
name: GalNAc transferase, Golgi apparatus
type: Reaction

metaR GCALDD
type: Reaction
product: MODEL1310110002#
fast: false
modifier: MODEL1310110002#
is described by: ECO:0000304
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.3
kinetic law: MODEL1310110002#
is: SBO:0000176
reactant: MODEL1310110002#
name: Glycolaldehyde dehydrogenase
is version of: http://identifiers.org/ec-code/1.2.1.36
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:11434452 NOTES:JLR
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM 34dhoxmand m
name: 3,4-Dihydroxymandelate
initial amount: NaN
is: CHEBI:27637
is: HMDB01866
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C8H7O5 CHARGE: -1 INCHI: InChI=1S/C8H8O5/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,9-11H,(H,12,13) HEPATONET_1.0_ABBREVIATION: HC01517 EHMN_ABBREVIATION: C05580
type: Species

metaM tdchola c
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: HMDB00951
name: taurochenodeoxycholate
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:9407
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species

metaR r0718
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.181
reversible: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (80270.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110002#
fast: false
name: (S)-3-Hydroxytetradecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211

metaR 5MTHFt
type: Reaction
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (2348.5) or (2348.3) or (2348.1) or (2348.6) or (2352.1) or (2348.4) or (2348.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:15094208 NOTES:IT
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis
is described by: ECO:0000269

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaM ksii core2 deg9 l
initial amount: NaN
is: CHEBI:12936
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 9
boundary condition: false
constant: false
is: HMDB00143
notes: FORMULA: C30H50N3O20X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110002#_4c819594_c94b_4afc_abf6_feea944df31b
type: Species
boundary condition: true
name: SLC38A3
constant: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q99624
is: SBO:0000252
is encoded by: hsa:10991

metaR r0365
is: SBO:0000176
modifier: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.1.72
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
fast: false
is described by: ECO:0000000
reversible: false

metaM 2mop c
is: HMDB01172
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(2-5)4(6)7/h2-3H,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00296 EHMN_ABBREVIATION: C00349
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
name: 2-methyl-3-oxopropanoate
is: CHEBI:57700
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110002#_e63418e8_7d7a_4f95_9737_40a0217fbd3b
is: SBO:0000252
type: Species
initial concentration: NaN
name: ALDH1B1
boundary condition: true
is: P30837
is encoded by: hsa:219
initial amount: NaN
has only substance units: false
constant: false

metaR DOLPGT1 Uer
product: MODEL1310110002#
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (uterus)
type: Reaction
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10359825 NOTES:EC 2.4.1.- NCD
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.267
fast: false
is: SBO:0000176
modifier: MODEL1310110002#
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#

metaR r1260
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
name: EC:6.2.1.3
is: SBO:0000176
reversible: false
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_705fa65c_d02a_44b0_ae61_78516486042e
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4830
initial amount: NaN
name: NME1
type: Species
initial concentration: NaN
constant: false

metaM HC01231 m
constant: false
boundary condition: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
type: Species
name: N-[(R)-pantothenoyl]-L-cysteinate
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:58480

http://identifiers.org/biomodels.db/MODEL1310110002#_b1707ee2_9b90_4d0f_b06d_082c53c3962c
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:763
initial amount: NaN
boundary condition: true
has only substance units: false
type: Species
name: CA5A
is: P35218

metaR r0587
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
product: MODEL1310110002#
type: Reaction
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
is described by: ECO:0000000
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_bcaec2cb_2796_4042_9fec_f3816d6b8b06
type: Species
is encoded by: hsa:2181
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: ACSL3
is: O95573

http://identifiers.org/biomodels.db/MODEL1310110002#_2836f448_2ca6_4cca_bd27_d9ee4867eab4
is: Q9BUM1
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:92579
initial concentration: NaN
type: Species
initial amount: NaN
name: G6PC3

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaM pail4p hs n
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3 EHMN_ABBREVIATION: C01277
initial concentration: 1.0
name: 1-phosphatidyl-1D-myo-inositol 4-phosphate(3-)
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:58178

http://identifiers.org/biomodels.db/MODEL1310110002#_3a046eac_6d45_41b1_8b9b_e8b0ee407c23
is encoded by: hsa:4833
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: O00746
type: Species
has only substance units: false
constant: false
name: NME4
initial amount: NaN

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

metaM acnacngalgbside hs e
has only substance units: false
name: disialyl galactosylgloboside
type: Species
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: C00036
boundary condition: false
constant: false
is: HMDB00223
is: CHEBI:3338

metaR r1748
kinetic law: MODEL1310110002#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_94df9e54_1390_4ef2_8b22_c967b49bc063
constant: false
initial amount: NaN
name: PEMT
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:10400

http://identifiers.org/biomodels.db/MODEL1310110002#_253fa0b3_73c5_4d17_b171_0621e9be58a7
initial amount: NaN
constant: false
has only substance units: false
name: _R39999_1_c
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:R39999

http://identifiers.org/biomodels.db/MODEL1310110002#_f6e2639e_58d3_4f7f_8891_f0026868f9d3
is: SBO:0000252
initial concentration: NaN
is: P40879
constant: false
boundary condition: true
is encoded by: hsa:1811
initial amount: NaN
name: SLC26A3
has only substance units: false
type: Species

metaR r2380
reversible: true
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110002#
is: SBO:0000185
fast: false
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR PAFH
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000269
reversible: false
name: Platelet-activating factor acetylhydrolase
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (5051.1) or (5049.1 and 5050.1) or (5049.1 and 5050.1 and 5048.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.47 Confidence Level: 4 AUTHORS: PMID:7669037,PMID:8028668,PMID:8955149 NOTES:NJ
product: MODEL1310110002#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/3.1.1.47

metaM retinal cis 13 r
name: 13-cis-retinal
constant: false
is: HMDB06220
initial concentration: 1.0
type: Species
boundary condition: false
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: CHEBI:45487
is: SBO:0000247
initial amount: NaN
has only substance units: false

metaR r1640
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false

metaM acac m
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
has only substance units: false
is: CHEBI:13705
is: HMDB00060
boundary condition: false
initial concentration: 1.0
name: acetoacetate
type: Species
initial amount: NaN
is: SBO:0000247
constant: false

metaM 4hexdtetcoa m
initial amount: NaN
type: Species
constant: false
is: HMDB02288
name: 4,7,10,13-hexadecatetraenoylcoa
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
boundary condition: false

metaR LEUKTRA4t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 1.1.1.27 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:9927705 NOTES:
kinetic law: MODEL1310110002#
reversible: true
reactant: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000269
fast: false
product: MODEL1310110002#
name: leukotriene A4 transport
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_001bd062_6f48_46c6_9e73_4c47a6ea682e
is encoded by: hsa:BC005314
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
name: _BC005314_1_x
type: Species
boundary condition: true
is: SBO:0000252

metaM ile L c
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:17191
boundary condition: false
has only substance units: false
name: L-isoleucine
is: HMDB00172
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
initial amount: NaN

metaM 3pg m
notes: FORMULA: C3H4O7P CHARGE: -3 INCHI: InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/p-3/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00186 EHMN_ABBREVIATION: C00197
initial amount: NaN
boundary condition: false
name: (2R)-2-hydroxy-3-(phosphonatooxy)propanoate
is: SBO:0000247
type: Species
is: HMDB00807
constant: false
has only substance units: false
is: CHEBI:58272
initial concentration: 1.0

metaR FAOXC10DCC8DCx
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10DC-->C8DC)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_09983017_99c4_4cb8_b5ae_f028c4b865b6
is encoded by: hsa:4714
is: SBO:0000252
initial concentration: NaN
name: NDUFB8
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is: O95169
constant: false

metaR GALACGLCGALGBSIDEte
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) - extracellular transport is also made available since metabolites can get to outer plasma membrane NJ
name: galacglcgalgbside hs transport
product: MODEL1310110002#
type: Reaction
reversible: true
is: SBO:0000185

metaR BDMT U
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (56052.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.142 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
product: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.142
name: GDPmannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase (uterus)

http://identifiers.org/biomodels.db/MODEL1310110002#_bc6ee656_f895_4019_b0fa_91a00aba69f6
is: Q9BZX2
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:7371
has only substance units: false
initial amount: NaN
name: UCK2
boundary condition: true

metaR HDCEAtr
is described by: ECO:0000000
name: fatty acid transport via diffusion
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110002#
reversible: true
type: Reaction
fast: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_450ca508_965b_4866_affd_96324716f10f
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:80025
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
name: PANK2

metaR FAOXC102m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

metaM so4 m
is: SBO:0000247
is: HMDB01448
boundary condition: false
is: CHEBI:16189
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: sulfate
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059

metaM 2oxoadp m
has only substance units: false
type: Species
is: CHEBI:57499
is: HMDB00225
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H6O5 CHARGE: -2 INCHI: InChI=1S/C6H8O5/c7-4(6(10)11)2-1-3-5(8)9/h1-3H2,(H,8,9)(H,10,11)/p-2 HEPATONET_1.0_ABBREVIATION: HC00273 EHMN_ABBREVIATION: C00322
is: SBO:0000247
name: 2-oxoadipate(2-)

http://identifiers.org/biomodels.db/MODEL1310110002#_88f20344_43bb_4cdf_b7ac_c3fe48284ec0
has only substance units: false
initial concentration: NaN
boundary condition: true
is: Q14032
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:570
constant: false
name: BAAT

metaM lnlnca l
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C18H29O2 CHARGE: -1 INCHI: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h3-4,6-7,9-10H,2,5,8,11-17H2,1H3,(H,19,20)/p-1/b4-3-,7-6-,10-9- HEPATONET_1.0_ABBREVIATION: HC01758 EHMN_ABBREVIATION: C06427
type: Species
is: HMDB01388
name: alpha-linolenate
is: CHEBI:32387
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_093953d8_6db9_4a7f_8eb3_a1f69300bdea
name: UGCG
constant: false
has only substance units: false
boundary condition: true
is: Q16739
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:7357
initial amount: NaN
type: Species

metaM tdchola e
has only substance units: false
type: Species
boundary condition: false
initial amount: NaN
is: HMDB00951
is: CHEBI:9407
name: taurochenodeoxycholate
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR CYTK5n
reactant: MODEL1310110002#
reversible: true
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
name: cytidylate kinase (CMP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM ump r
is: SBO:0000247
type: Species
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
constant: false
initial concentration: 1.0
is: CHEBI:57865
has only substance units: false
name: UMP
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_metaR_FUCFUCFUCGALACGLC13GALACGLCGAL14ACGLCGALGLUSIDEte
name: blood group intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_8ef61062_6686_4163_866e_cf038f76a721
type: Species
initial amount: NaN
initial concentration: NaN
name: _U37519_1_e
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:U37519

metaM acnacngalgbside hs g
is: C00036
initial amount: NaN
constant: false
is: HMDB00223
boundary condition: false
is: CHEBI:3338
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
name: disialyl galactosylgloboside

http://identifiers.org/biomodels.db/MODEL1310110002#_195aa15b_c967_4237_ae18_229062e861e9
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
is encoded by: hsa:AI440329
initial amount: NaN
constant: false
type: Species
name: _AI440329_1_r

metaM 3decdicoa m
initial concentration: 1.0
has only substance units: false
name: 3,7-decadienoylcoa
type: Species
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_99d1f9c4_a266_4c73_91ad_f51c25dd4fa7
type: Species
name: SLC16A7
is encoded by: hsa:9194
is: Q8NEM3
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_e98fb73c_48b9_4b93_8c03_671beadbd570
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
boundary condition: true
name: FOLR1
is encoded by: hsa:2348
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_55bd64a8_8dd9_4517_ab11_748a065940f2
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: F8WDN9
has only substance units: false
is encoded by: hsa:27068
constant: false
is: SBO:0000252
name: PPA2
type: Species

metaM cspg d l
is: HMDB00062
boundary condition: false
constant: false
name: chondroitin sulfate D (GlcNAc6S-GlcA2S) proteoglycan
has only substance units: false
is: CHEBI:16347
is: C00318
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C45H64N2O51S5X CHARGE: -7
initial concentration: 1.0

metaR G6Pter
fast: false
product: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (2542.1) SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 4 AUTHORS: PMID:11032333,PMID:11140953,PMID:11879177,PMID:9428641 NOTES:NCD
name: glucose 6-phosphate endoplasmic reticular transport via diffusion
is described by: ECO:0000269
type: Reaction
reversible: true
is: SBO:0000185

metaM hyptaur c
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519
is: CHEBI:16668
is: SBO:0000247
is: HMDB00965
name: Hypotaurine

metaR GMPR
modifier: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/1.7.1.7
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (2766.1) or (51292.1) or (51292.3) or (51292.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.7.1.7 Confidence Level: 4 AUTHORS: PMID:12009299,PMID:8188226 NOTES:
name: GMP reductase
is: SBO:0000176
reactant: MODEL1310110002#
is described by: ECO:0000269
fast: false
product: MODEL1310110002#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110002#_ec5fd114_e930_4a7b_bde5_3490b20e0dc0
boundary condition: true
is encoded by: hsa:BE042354
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: _BE042354_1_m
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_77181b16_508a_4285_865f_ab177d0330ac
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:AI469183
name: _AI469183_1_x
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_a4746921_9062_4244_bc36_9ee58c5befcf
is encoded by: hsa:H77542
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
name: _H77542_1_r
type: Species
is: SBO:0000252
boundary condition: true

metaR PAIL45P HStn
is described by: ECO:0000000
reactant: MODEL1310110002#
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
fast: false
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110002#

metaM xol7a r
initial amount: NaN
initial concentration: 1.0
type: Species
is: CHEBI:1296
constant: false
boundary condition: false
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C03594
name: 20-hydroxycholesterol
has only substance units: false
is: HMDB01496
is: SBO:0000247

metaM ile L e
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: SBO:0000247
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00172
type: Species
is: CHEBI:17191
name: L-isoleucine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_c
has only substance units: false
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:15347
is: HMDB01659
name: Type IIIA glycolipid
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_22a17759_e9af_42f0_907b_5ae4201af52e
name: B3GNTL1
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:146712
is: Q67FW5
constant: false
boundary condition: true

metaM CE5132 c
boundary condition: false
constant: false
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
initial amount: NaN
has only substance units: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
type: Species
initial concentration: 1.0
is: CHEBI:57923

metaR SUCD1m
is: SBO:0000176
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.5.1
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
reversible: true
fast: false
is described by: ECO:0000134
name: succinate dehydrogenase
product: MODEL1310110002#

metaR RE0383C
is: SBO:0000176
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.2
name: RE0383
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (10327.1) SUBSYSTEM: Miscellaneous EC Number: 1.1.1.2 Confidence Level: 0 AUTHORS: PMID:1748675 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
modifier: MODEL1310110002#

metaR RE3005M
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.107
name: RE3005
is described by: ECO:0000000
product: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_75ca589d_7b5c_406c_b8ba_0d9f7239cc24
constant: false
is encoded by: hsa:3948
boundary condition: true
is: SBO:0000252
name: LDHC
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_e25c7b0c_382d_41a5_b96a_cebbc3c2bb05
boundary condition: true
is: SBO:0000252
constant: false
is: O14975
type: Species
initial amount: NaN
has only substance units: false
name: SLC27A2
is encoded by: hsa:11001
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_4ab1c319_558b_412e_902f_b267f40c7afb
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
is: F5H2Y9
name: ALDH1A2
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8854

http://identifiers.org/biomodels.db/MODEL1310110002#_c3cdc81f_06db_419c_bef6_4c19eb96f083
is: SBO:0000252
is encoded by: hsa:3613
type: Species
boundary condition: true
has only substance units: false
is: O14732
initial concentration: NaN
initial amount: NaN
name: IMPA2
constant: false

metaR r0584
kinetic law: MODEL1310110002#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110002#
fast: false
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
product: MODEL1310110002#
type: Reaction

metaR ACALDt
kinetic law: MODEL1310110002#
is: SBO:0000185
reversible: true
type: Reaction
is described by: ECO:0000000
fast: false
name: acetaldehyde reversible transport
product: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaM oaa c
constant: false
is: C00036
is: HMDB00223
name: Oxaloacetate
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C4H2O5 CHARGE: -2
is: SBO:0000247
initial amount: NaN
type: Species
is: CHEBI:3338
has only substance units: false

metaR CYSGLYexR
is: SBO:0000185
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
is described by: ECO:0000000
fast: false
name: L-cysteine/glycine reversible exchanger
reversible: true
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#

metaR r0797
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12810727,PMID:6884990 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110002#
is described by: ECO:0000000
name: glycine N-choloyltransferase EC:2.3.1.65
kinetic law: MODEL1310110002#
is: SBO:0000176
fast: false
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.2.1.5

metaM acgam r
is: SBO:0000247
is: HMDB00215
initial amount: NaN
constant: false
initial concentration: 1.0
name: N-acetyl-D-glucosamine
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
boundary condition: false
is: CHEBI:17411
has only substance units: false

metaR r0714
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35

metaR EX 10fthf7glu LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 10-formyltetrahydrofolate-[Glu](7) exchange
type: Reaction

metaR r2385
kinetic law: MODEL1310110002#
is: SBO:0000185
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
is described by: ECO:0000000
product: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#

metaM aps c
notes: FORMULA: C10H12N5O10PS CHARGE: -2 INCHI: InChI=1S/C10H14N5O10PS/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-26(18,19)25-27(20,21)22/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H,20,21,22)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00204 EHMN_ABBREVIATION: C00224
initial concentration: 1.0
is: CHEBI:58243
type: Species
has only substance units: false
name: 5'-adenylyl sulfate(2-)
is: HMDB01003
constant: false
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR KYNATESYN
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
reactant: MODEL1310110002#
product: MODEL1310110002#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110002#
fast: false

metaR SERDGLNexR
is: SBO:0000185
name: D-Serine/Glutamine reversible exchange
reversible: true
is described by: ECO:0000304
reactant: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
type: Reaction

metaR EX utp LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: UTP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_207526b4_b7d6_4488_ac54_007529bae60d
initial amount: NaN
name: TMEM54
has only substance units: false
type: Species
is: Q969K7
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:113452
boundary condition: true
constant: false

metaR r0641
is described by: ECO:0000000
fast: false
is version of: http://identifiers.org/ec-code/3.1.2.4
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (26275.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.2.2 Confidence Level: 0 AUTHORS: PMID:1968061 NOTES:
product: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
reversible: true
name: (5-Glutamyl)-peptide:amino-acid 5-glutamyltransferase Arachidonic acid metabolism EC:2.3.2.2

metaR CYTDK1
is: SBO:0000176
kinetic law: MODEL1310110002#
is described by: ECO:0000254
fast: false
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.48
modifier: MODEL1310110002#
product: MODEL1310110002#
name: ATPcytidine 5-phosphotransferase
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaM mal L m
is: CHEBI:15589
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
constant: false
is: HMDB00156
boundary condition: false
name: (S)-malate(2-)

http://identifiers.org/biomodels.db/MODEL1310110002#_metaR_FUCFUCFUCGALACGLC13GALACGLCGAL14ACGLCGALGLUSIDEtg
name: blood group intracellular transport
product: MODEL1310110002#
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however these blood groups need to make it to the extracellular surface of cells NJ

metaR r2384
modifier: MODEL1310110002#
reversible: false
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
kinetic law: MODEL1310110002#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:

metaM dgmp m
has only substance units: false
initial concentration: 1.0
is: HMDB01044
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
name: dGMP
is: CHEBI:57673
is: C00362
type: Species

metaR r0715
fast: false
is version of: http://identifiers.org/ec-code/6.3.2.5
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
name: (S)-3-Hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (AI435857.1) or (79717.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:

metaR r2420
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
reversible: true

metaM C05965 e
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
name: 12(S)-HPETE(1-)
boundary condition: false
constant: false
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
is: HMDB04243
is: CHEBI:57444

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_e
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: HMDB01659
is: SBO:0000247
type: Species
is: CHEBI:15347
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
name: Type IIIA glycolipid
boundary condition: false

metaM so4 l
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
boundary condition: false
type: Species
initial concentration: 1.0
name: sulfate
initial amount: NaN
is: CHEBI:16189
constant: false
is: SBO:0000247
is: HMDB01448
has only substance units: false

metaM xylt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
is: CHEBI:17151
initial amount: NaN
is: SBO:0000247
name: xylitol
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB02917
has only substance units: false

ORG:
  orgname: University of Manchester
n:
  given: Neil
  family: Swainston

http://identifiers.org/biomodels.db/MODEL1310110002#_05131471_460f_4c3f_8b20_872cd6707f70
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
is: O15254
is: SBO:0000252
name: ACOX3
boundary condition: true
has only substance units: false
is encoded by: hsa:8310

metaR B3GNT12g
is version of: http://identifiers.org/ec-code/2.4.1.149
product: MODEL1310110002#
is: SBO:0000176
modifier: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (10678.1) or (10678.2) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12855703 NOTES:NJ
reactant: MODEL1310110002#
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
reversible: false
kinetic law: MODEL1310110002#
is described by: ECO:0000269
type: Reaction

metaR B3GNT310g
type: Reaction
reactant: MODEL1310110002#
reversible: false
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10072769 NOTES:NJ
kinetic law: MODEL1310110002#
fast: false
is: SBO:0000176
product: MODEL1310110002#
is described by: ECO:0000254
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus

metaR SIAT9g
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110002#
reversible: false
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
fast: false
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.99.9
product: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_5552db6a_a413_40a3_ba3f_f5f1c3daa4c5
is encoded by: hsa:1468
is: Q9UBX3
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
name: SLC25A10

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_acgalfucgalacglcgal14acglcgalgluside_hs_g
constant: false
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)2 (LFuc)1 (Cer)1
boundary condition: false
type: Species
notes: FORMULA: C72H125N4O41FULLRCO CHARGE: 0
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:61648
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_b21db860_2a38_4e25_ab64_963f97e359ee
has only substance units: false
initial concentration: NaN
is encoded by: hsa:8526
initial amount: NaN
type: Species
name: DGKE
is: A1L4Q0
is: SBO:0000252
boundary condition: true
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_085bd817_311f_4bdb_ada2_29e2c055ff56
is: B4E3E9
has only substance units: false
type: Species
constant: false
is encoded by: hsa:4967
name: OGDH
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_8661b64b_1a8d_43ed_836c_ac11b80db3c8
is encoded by: hsa:10559
is: P78382
is: SBO:0000252
has only substance units: false
type: Species
name: SLC35A1
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_655a4a19_0533_4fee_9a99_0bc295d69fc2
initial concentration: NaN
boundary condition: true
is: Q9P109
has only substance units: false
is encoded by: hsa:51301
initial amount: NaN
is: SBO:0000252
name: GCNT4
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_a0d96b01_e326_43fd_af6f_e4ce3a6899e8
initial amount: NaN
constant: false
name: BDH1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:622

metaR r0642
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10947204,PMID:10989432,PMID:1527093,PMID:16683190,PMID:8120000,PMID:8155713,PMID:8634152,PMID:9787093 NOTES:
fast: false
kinetic law: MODEL1310110002#
name: (S)-Methylmalonate semialdehyde:NAD+ oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.1.3
is: SBO:0000176
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_c10c00b9_432b_4fff_a976_2bd66b796110
has only substance units: false
initial amount: NaN
is encoded by: hsa:56623
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: Q9NRR6
name: INPP5E

metaM core4 g
constant: false
initial amount: NaN
is: CHEBI:16478
initial concentration: 1.0
name: Core 4
boundary condition: false
notes: FORMULA: C24H40N3O15X CHARGE: 0
has only substance units: false
is: SBO:0000247
type: Species

metaM thr L e
boundary condition: false
name: L-threonine
is: CHEBI:16857
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
is: HMDB00167
has only substance units: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_ac69853b_c925_4b35_8b89_29879ae56130
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:2348
name: FOLR1
is: P15328
boundary condition: true
has only substance units: false
constant: false

metaR r0796
is described by: ECO:0000000
kinetic law: MODEL1310110002#
name: Ribitol:NAD+ 2-oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.56
type: Reaction
modifier: MODEL1310110002#
product: MODEL1310110002#
fast: false
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.5
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: PMID:15234337 NOTES:
reactant: MODEL1310110002#

metaR FUT16g
product: MODEL1310110002#
fast: false
is: SBO:0000176
is described by: ECO:0000269
reversible: false
type: Reaction
modifier: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (2523.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.69 Confidence Level: 4 AUTHORS: PMID:2118655 NOTES:NJ
name: Galactoside 2-alpha-L-fucosyltransferase 1
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.69

metaM ksi pre26 g
initial concentration: 1.0
constant: false
name: keratan sulfate I biosynthesis, precursor 26
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:28067
boundary condition: false
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
type: Species

metaR CYOR u10m
name: ubiquinol-6 cytochrome c reductase, Complex III
product: MODEL1310110002#
reversible: false
fast: false
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.5.1.92
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (8876.1) and (8875.2) and (55350.3) or (8876.1) and (8875.2) and (55350.2) or (8876.1) and (8875.1) and (55350.1) or (8876.1) and (55350.2) and (8875.1) or (8875.2) and (8876.1) and (55350.1) or (8876.1) and (55350.3) and (8875.1) or (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10453733,PMID:11047755 NOTES:INVALID ECO TERM: IFH
type: Reaction
reactant: MODEL1310110002#
is described by: ECO:0000134
modifier: MODEL1310110002#
is: SBO:0000185

metaR RE1520M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
name: RE1520
modifier: MODEL1310110002#
fast: false
reactant: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_fd842319_ebea_457c_a9cd_dfb08530d420
type: Species
initial amount: NaN
name: CPT2
constant: false
initial concentration: NaN
has only substance units: false
is: P23786
boundary condition: true
is encoded by: hsa:1376
is: SBO:0000252

metaR r0716
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110002#
reversible: false
kinetic law: MODEL1310110002#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110002#
is: SBO:0000176

metaM cs d deg1 l
is: SBO:0000247
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 1
boundary condition: false
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: HMDB00812
is: CHEBI:16953
initial concentration: 1.0

ORG:
  orgname: University of Iceland
n:
  given: Ines
  family: Thiele

metaR PI45PLC
modifier: MODEL1310110002#
is: SBO:0000176
reactant: MODEL1310110002#
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: false
name: phosphatidylinositol 4,5-bisphosphate phospholipase C
is version of: http://identifiers.org/ec-code/3.1.4.11
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (9651.1) or (113026.1) or (89869.1) or (84812.1) or (5330.1) or (5335.1) or (51196.1) or (5333.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (257068.1) or (23236.1) or (23007.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.11 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110002#_12861e61_a416_49eb_99e0_7290c291cf3a
type: Species
initial amount: NaN
boundary condition: true
is: Q9P0J0
is: SBO:0000252
is encoded by: hsa:51079
has only substance units: false
constant: false
name: NDUFA13
initial concentration: NaN

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_48f4ffc3_cb99_4091_a464_36372cfffe43
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SHMT1
has only substance units: false
type: Species
is encoded by: hsa:6470
constant: false
is: P34896
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_3caefd8d_101b_46b5_9c8f_f4ba6b690cc6
is encoded by: hsa:55577
is: SBO:0000252
type: Species
name: NAGK
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
is: Q9UJ70
initial concentration: NaN

metaR r2090
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is: SBO:0000185
fast: false
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110002#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_39060d33_159c_4b74_8612_4306966a4310
has only substance units: false
name: COX5B
is: Q53YB7
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
is encoded by: hsa:1329
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_e49339d7_4a7d_40e3_93a4_a5ec341ebec0
initial concentration: NaN
is: D9HTE9
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
name: SLC25A1
constant: false
is: SBO:0000252
is encoded by: hsa:6576

http://identifiers.org/biomodels.db/MODEL1310110002#_3e4cf352_fd37_4dcb_bdee_83c1564156a7
initial concentration: NaN
name: CHAT
has only substance units: false
type: Species
is encoded by: hsa:1103
is: P28329
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_7aab7eed_1d30_41ee_92fa_c82dfcc6f382
is encoded by: hsa:8875
is encoded by: hsa:55350
constant: false
is: SBO:0000297
has part: A8K7W0
boundary condition: true
name: VNN3:VNN2:VNN1
is encoded by: hsa:8876
initial concentration: NaN
initial amount: NaN
has only substance units: false
type: Species
has part: O95497

metaM paps g
boundary condition: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
is: HMDB01134
is: CHEBI:58339
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_695274ec_f9cd_4b42_bd0f_a1198349b146
name: SLC22A3
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q5SYN6
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:6581
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_14e5248e_09b7_44fb_8a37_b88c747a1051
is: SBO:0000252
is: P42765
is encoded by: hsa:10449
constant: false
type: Species
initial amount: NaN
name: ACAA2
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM glc D r
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00040
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: D-glucose
is: HMDB00122
constant: false
boundary condition: false
type: Species
has only substance units: false
is: CHEBI:4167

metaM ump n
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: UMP(2-)
constant: false
is: HMDB00288
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
has only substance units: false
is: SBO:0000247

metaM glyc R c
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00139
name: D-glycerate
is: CHEBI:16659
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
boundary condition: false

metaR r0644
reversible: true
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
name: (S)-Methylmalonate semialdehyde:oxygen oxidoreductase Valine, leucine and isoleucine degradation EC:1.2.3.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
is: SBO:0000176
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
fast: false

metaM xylt c
is: SBO:0000247
boundary condition: false
constant: false
type: Species
has only substance units: false
name: xylitol
initial concentration: 1.0
is: HMDB02917
initial amount: NaN
is: CHEBI:17151
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379

http://identifiers.org/biomodels.db/MODEL1310110002#_ed4d91fa_bf94_4029_a15c_5579ccf2159c
type: Species
name: GMPR
boundary condition: true
has only substance units: false
is: P36959
constant: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:2766

http://identifiers.org/biomodels.db/MODEL1310110002#_b6bef6f7_672c_4c51_afea_00bcc733fa68
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:6487
type: Species
initial amount: NaN
initial concentration: NaN
name: ST3GAL3

metaM fadh2 m
is: CHEBI:58307
is: C01352
constant: false
notes: FORMULA: C27H33N9O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00770 EHMN_ABBREVIATION: C01352
boundary condition: false
type: Species
is: HMDB01197
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: Flavin adenine dinucleotide reduced

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_acgalfucgalacgalfuc12gal14acglcgalgluside_hs_g
initial concentration: 1.0
is: CHEBI:57847
initial amount: NaN
has only substance units: false
boundary condition: false
name: Type IIIA glycolipid
constant: false
notes: FORMULA: C78H135N4O45FULLRCO CHARGE: 0
is: SBO:0000247
type: Species
is: HMDB00304

metaR DGK1
reversible: true
reactant: MODEL1310110002#
fast: false
name: deoxyguanylate kinase (dGMP:ATP)
type: Reaction
modifier: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.8
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is described by: ECO:0000269
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_684d0322_b0c6_4e9e_acae_0d5760e6cef6
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:51022
is: Q9NS18
boundary condition: true
name: GLRX2

metaR r2382
product: MODEL1310110002#
is: SBO:0000185
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
type: Reaction
modifier: MODEL1310110002#
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

http://identifiers.org/biomodels.db/MODEL1310110002#_df03475b_09c0_488d_94f0_f1081ab9258d
initial concentration: NaN
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:5298
name: PI4KB
is: Q9UBF8
constant: false
boundary condition: true

metaR r0717
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110002#
name: (S)-3-Hydroxyhexadecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
type: Reaction
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
product: MODEL1310110002#
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_84400a55_efcc_4f2f_95a2_8ef8fe137ff5
initial concentration: NaN
boundary condition: true
is: Q6NSB3
has only substance units: false
constant: false
is: SBO:0000252
name: AMY1A
is encoded by: hsa:276
initial amount: NaN
type: Species

metaR GALACGLCGALGBSIDEtg
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:8206147 NOTES:unknown mechanism for transport - intracellular transport occurs, most details are unknown - see for example Varki glycobiology text or numerous reviews (PMID: 8206147) NJ
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110002#
reversible: true
name: galacglcgalgbside hs intracellular transport

metaR GALASE18ly
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
kinetic law: MODEL1310110002#
name: beta-galactosidase, lysosomal
fast: false
type: Reaction
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110002#
reactant: MODEL1310110002#

metaM gtp c
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
name: GTP
is: CHEBI:37565
constant: false
is: HMDB01273
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: C00044
type: Species

metaR r0580
type: Reaction
reactant: MODEL1310110002#
is: SBO:0000176
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
modifier: MODEL1310110002#
reversible: true
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
is version of: http://identifiers.org/ec-code/1.3.99.7

metaM thr L c
name: L-threonine
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00167
is: CHEBI:16857
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_2bd46d39_3182_448f_b029_4bdcfae17807
is: SBO:0000252
type: Species
is encoded by: hsa:8604
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
name: SLC25A12
is: O75746
has only substance units: false

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaM xol7ah2al c
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
is: HMDB06894
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial amount: NaN
constant: false
is: SBO:0000247
type: Species
is: CHEBI:27428

metaR UDPGALtg
name: UDP-Gal Golgi transport via CMP antiport
fast: false
product: MODEL1310110002#
is: SBO:0000185
modifier: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
reversible: true
kinetic law: MODEL1310110002#
type: Reaction
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110002#_31b13889_c3ed_4f4c_913d_874438465e19
boundary condition: true
is: SBO:0000252
name: DHCR24
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1718
is: Q15392
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_85e497d5_dd74_4585_952b_52d6f72443f7
has only substance units: false
is encoded by: hsa:81537
constant: false
is: Q9BX95
initial amount: NaN
name: SGPP1
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaR r1636
is described by: ECO:0000000
product: MODEL1310110002#
modifier: MODEL1310110002#
reactant: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_eaa3cbe9_bd38_4408_ab3c_5ccbd42c7f99
has only substance units: false
is encoded by: hsa:27034
initial concentration: NaN
type: Species
constant: false
is: Q6ZWP6
initial amount: NaN
is: SBO:0000252
name: ACAD8
boundary condition: true

metaM 5mthf e
name: 5-Methyltetrahydrofolate
boundary condition: false
type: Species
is: HMDB01396
is: CHEBI:3729
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: C00440
notes: FORMULA: C20H24N7O6 CHARGE: -1

metaR RE3624M
product: MODEL1310110002#
modifier: MODEL1310110002#
reversible: false
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
is: SBO:0000176
reactant: MODEL1310110002#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
type: Reaction
name: RE3624
fast: false
kinetic law: MODEL1310110002#

metaR r0033
modifier: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
reactant: MODEL1310110002#
fast: false
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
product: MODEL1310110002#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5

metaM thym e
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
boundary condition: false
is: CHEBI:17821
is: HMDB00262
name: thymine
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_09854631_d05c_45f8_8a8c_c12109e2a018
initial concentration: NaN
type: Species
name: LDHAL6B
is: Q9BYZ2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:92483
constant: false
boundary condition: true
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_4b8549ad_00f0_4e79_8b37_733a35aa63bd
type: Species
boundary condition: true
constant: false
has only substance units: false
is: Q5QPH3
name: ACSS2
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55902
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_8258e416_fa51_462d_940c_1dcf0a072bd3
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
name: _AI990637_1_x
is: SBO:0000252
is encoded by: hsa:AI990637

metaR ESTRADIOLtr
name: estradiol intracellular transport
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
is: SBO:0000185
fast: false
kinetic law: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_5ff17978_a3ea_4197_b2b8_103eab8a7b5f
initial amount: NaN
is: Q9H999
constant: false
initial concentration: NaN
has only substance units: false
name: PANK3
type: Species
is encoded by: hsa:79646
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_bb3876f5_feb5_4915_a014_91081d45839a
name: HADH
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: Q16836
is: SBO:0000252
is encoded by: hsa:3033
type: Species
boundary condition: true

metaR CHSTEROLt2
product: MODEL1310110002#
is: SBO:0000185
kinetic law: MODEL1310110002#
name: cholesterol intracellular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reactant: MODEL1310110002#
fast: false
reversible: true
type: Reaction

metaR r2388
product: MODEL1310110002#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110002#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_423f8c63_d7b3_4c77_80b7_076f3755ecd2
initial amount: NaN
name: ENTPD1
boundary condition: true
has only substance units: false
is: SBO:0000252
type: Species
is encoded by: hsa:953
is: Q86VV3
initial concentration: NaN
constant: false

metaR r2419
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:
is described by: ECO:0000000
reversible: true
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
is: SBO:0000185
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
fast: false

metaM ppi r
type: Species
initial amount: NaN
is: CHEBI:33019
is: SBO:0000247
is: HMDB00250
boundary condition: false
constant: false
name: Diphosphate
is: C00013
initial concentration: 1.0
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_6936113a_67f1_4dbb_8239_cd9a3929cf86
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:229
is: SBO:0000252
is: P05062
constant: false
initial amount: NaN
name: ALDOB
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_e0920bc8_3be4_4078_ae30_6313099e8ad5
type: Species
name: IDH2
initial concentration: NaN
is encoded by: hsa:3418
boundary condition: true
has only substance units: false
is: P48735
is: SBO:0000252
constant: false
initial amount: NaN

metaM m4mpdol U r
initial amount: NaN
type: Species
is: CHEBI:37633
is: SBO:0000247
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial concentration: 1.0
has only substance units: false
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
boundary condition: false

metaM HC01407 m
boundary condition: false
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
initial amount: NaN
type: Species
name: (S)-Hydroxyhexanoyl-CoA
has only substance units: false
is: CHEBI:28276
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR r1635
reactant: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110002#
fast: false
product: MODEL1310110002#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_3861fb2b_6fb4_4238_8dd9_136438ffdf4c
is: Q10469
is encoded by: hsa:4247
boundary condition: true
is: SBO:0000252
initial concentration: NaN
name: MGAT2
initial amount: NaN
constant: false
has only substance units: false
type: Species

metaR PEPCKm
kinetic law: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
fast: false
reactant: MODEL1310110002#
name: Phosphoenolpyruvate carboxykinase (GTP)
modifier: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.32

metaM andrstrn r
boundary condition: false
name: androsterone
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00031
initial amount: NaN
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00523
type: Species
initial concentration: 1.0
is: CHEBI:16032

http://identifiers.org/biomodels.db/MODEL1310110002#_f553f378_01df_4466_879c_f81b9ec76e76
name: AKR1C4
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P17516
has only substance units: false
constant: false
is encoded by: hsa:1109
initial concentration: NaN
type: Species

metaR r2080
kinetic law: MODEL1310110002#
is described by: ECO:0000000
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
reactant: MODEL1310110002#
product: MODEL1310110002#
type: Reaction

metaR CHSTEROLt3
kinetic law: MODEL1310110002#
product: MODEL1310110002#
name: cholesterol intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12370263,PMID:12770731 NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
reversible: true
reactant: MODEL1310110002#
is described by: ECO:0000000
fast: false
is: SBO:0000185
type: Reaction

metaR r2389
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
kinetic law: MODEL1310110002#
type: Reaction
is: SBO:0000185
product: MODEL1310110002#
is described by: ECO:0000000
modifier: MODEL1310110002#
fast: false
reversible: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2

metaR RE1903R
reactant: MODEL1310110002#
is: SBO:0000176
type: Reaction
product: MODEL1310110002#
name: RE1903
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 1.2.1.36 Confidence Level: 0 AUTHORS: PMID:10559215,PMID:11007799 NOTES:
kinetic law: MODEL1310110002#
is described by: ECO:0000000
fast: false

metaR PI45P3K
reactant: MODEL1310110002#
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.1.153
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.11.1
product: MODEL1310110002#

metaR EX maltpt LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltopentaose exchange
type: Reaction

metaR ALDD2y
product: MODEL1310110002#
reversible: false
modifier: MODEL1310110002#
is: SBO:0000176
name: aldehyde dehydrogenase (acetaldehyde, NADP)
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
kinetic law: MODEL1310110002#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_2a9b3603_53c0_4d02_bdbb_7d3a53ee1b9f
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: A8K3J4
is: SBO:0000252
name: CA14
is encoded by: hsa:23632

http://identifiers.org/biomodels.db/MODEL1310110002#_8bcd8ca9_406c_4537_8bd8_36f80ccd4a3e
is encoded by: hsa:AA629629
name: _AA629629_1_m
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_6f169d5b_b408_4227_8ee9_a1ff8f6d2c4b
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:AU149534
name: _AU149534_1_c
has only substance units: false
constant: false

metaR RNMK
name: ribosylnicotinamide kinase
product: MODEL1310110002#
modifier: MODEL1310110002#
reversible: false
fast: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.22
type: Reaction
notes: GENE_ASSOCIATION: (54981.1) SUBSYSTEM: NAD metabolism EC Number: 2.7.1.22 Confidence Level: 4 AUTHORS: PMID:15137942 NOTES:

metaR r1634
product: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110002#
is: SBO:0000185
type: Reaction
reversible: true
fast: false

metaM ura e
initial amount: NaN
is: CHEBI:17568
has only substance units: false
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
boundary condition: false
constant: false
name: uracil
initial concentration: 1.0
is: HMDB00300
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_c9be33c2_3ff4_444d_999b_ccc57c4425a6
type: Species
boundary condition: true
constant: false
is encoded by: hsa:6184
is: P04843
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: RPN1
is: SBO:0000252

metaM 5mthf c
is: CHEBI:3729
has only substance units: false
name: 5-Methyltetrahydrofolate
constant: false
notes: FORMULA: C20H24N7O6 CHARGE: -1
boundary condition: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: HMDB01396
is: C00440

metaR r2081
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_bb9c3687_4c00_4d0b_b950_f49869438b9a
name: SUCLG1
constant: false
is encoded by: hsa:8802
initial concentration: NaN
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
has only substance units: false
is: P53597

http://identifiers.org/biomodels.db/MODEL1310110002#_f4a098fd_2dea_49e0_90c6_4b5ab834d834
is encoded by: hsa:2222
initial amount: NaN
is: P37268
has only substance units: false
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: FDFT1
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_3a52afd9_155d_49aa_82db_f4184d8059ea
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: _AA081045_1_m
initial concentration: NaN
type: Species
is encoded by: hsa:AA081045

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR RE1807C
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
reversible: true
reactant: MODEL1310110002#
name: RE1807
is described by: ECO:0000000
fast: false
is: SBO:0000176
type: Reaction
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_d0a35a8e_5080_4f7d_83bb_41fae90489d0
is: Q9H008
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:64077
is: SBO:0000252
name: LHPP
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_81c466b6_337e_4b28_881a_8e29f15679fc
initial concentration: NaN
name: AMY1C
is: SBO:0000252
constant: false
has only substance units: false
is: P04745
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:278

http://identifiers.org/biomodels.db/MODEL1310110002#_396ee4d0_ce08_40d5_9677_b95a8feae023
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:50700
constant: false
boundary condition: true
is: Q9NYR8
type: Species
name: RDH8
is: SBO:0000252

metaR TRPHYDRO2
kinetic law: MODEL1310110002#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
product: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.16.4
is: SBO:0000176
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
modifier: MODEL1310110002#
fast: false
is described by: ECO:0000269
reversible: false

metaR r1378
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110002#
fast: false
name: S-(hydroxymethyl)glutathione dehydrogenase Methane metabolism EC:1.1.1.284
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.1.1.284 Confidence Level: 0 AUTHORS: PMID:18288723 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#

metaR r2386
product: MODEL1310110002#
is: SBO:0000185
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110002#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
reversible: false
reactant: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
fast: false

metaR CMPACNAtg
name: CMP-Sia Golgi transport via CMP antiport
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
reactant: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
is described by: ECO:0000269
type: Reaction
reversible: true
product: MODEL1310110002#
is: SBO:0000185

metaM amp e
is: CHEBI:456215
type: Species
name: AMP
has only substance units: false
constant: false
is: HMDB00045
is: C00020
is: SBO:0000247
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaM udpg c
is: C00029
boundary condition: false
initial amount: NaN
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00038 EHMN_ABBREVIATION: C00029
type: Species
has only substance units: false
is: SBO:0000247
name: UDPglucose
is: CHEBI:58367
constant: false
is: HMDB00286
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_b96bdba9_2895_416c_8234_5ba1839664e8
type: Species
is encoded by: hsa:64064
initial concentration: NaN
has only substance units: false
name: OXCT2
boundary condition: true
constant: false
is: Q9BYC2
is: SBO:0000252
initial amount: NaN

metaR ALDD2x
is version of: http://identifiers.org/ec-code/1.2.1.5
name: aldehyde dehydrogenase (acetaldehyde, NAD)
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.36
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
fast: false
is version of: http://identifiers.org/ec-code/1.2.1.3
product: MODEL1310110002#
reversible: false
is described by: ECO:0000000

metaM thp2c x
name: 1-piperideine-6-carboxylate
is: CHEBI:16987
constant: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C6H8NO2 CHARGE: -1 INCHI: InChI=1S/C6H9NO2/c8-6(9)5-3-1-2-4-7-5/h4-5H,1-3H2,(H,8,9)/p-1 EHMN_ABBREVIATION: C00450
is: HMDB12130
boundary condition: false

metaM ppcoa m
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:57392
constant: false
has only substance units: false
is: HMDB01275
is: C00100
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
initial amount: NaN
name: Propanoyl-CoA

metaR r1633
kinetic law: MODEL1310110002#
type: Reaction
reversible: true
reactant: MODEL1310110002#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110002#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR FAOXC180
modifier: MODEL1310110002#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (34.1) or (35.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
reactant: MODEL1310110002#
fast: false
type: Reaction
name: Beta oxidation of long chain fatty acid
kinetic law: MODEL1310110002#
is described by: ECO:0000269
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.3.8.1

metaM paps c
is: HMDB01134
name: (2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-2-({[(sulfonatooxy)phosphinato]oxy}methyl)oxolan-3-yl phosphate
constant: false
notes: FORMULA: C10H11N5O13P2S CHARGE: -4 INCHI: InChI=1S/C10H15N5O13P2S/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(27-29(17,18)19)4(26-10)1-25-30(20,21)28-31(22,23)24/h2-4,6-7,10,16H,1H2,(H,20,21)(H2,11,12,13)(H2,17,18,19)(H,22,23,24)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00058 EHMN_ABBREVIATION: C00053
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58339
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR ACGALtlg
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism - may be vesicular NJ
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
is described by: ECO:0000000
type: Reaction
name: N-acetyl-galactosamine intracellular transport
fast: false
kinetic law: MODEL1310110002#

metaR r2082
fast: false
kinetic law: MODEL1310110002#
reversible: true
is: SBO:0000185
reactant: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
product: MODEL1310110002#

metaR DOLASNT Uer
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD
reactant: MODEL1310110002#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.119
product: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
fast: false
modifier: MODEL1310110002#
reversible: false
type: Reaction

metaR r0145
reactant: MODEL1310110002#
is: SBO:0000176
reversible: true
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
product: MODEL1310110002#
type: Reaction
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.8.3.1
fast: false
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110002#

metaM o2s e
initial concentration: 1.0
name: superoxide
is: CHEBI:18421
is: HMDB02168
constant: false
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247

metaR r2387
fast: false
modifier: MODEL1310110002#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110002#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (215.1) or (U52111.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
reversible: false
reactant: MODEL1310110002#

metaM ump g
constant: false
boundary condition: false
type: Species
has only substance units: false
is: HMDB00288
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:57865
notes: FORMULA: C9H11N2O9P CHARGE: -2 INCHI: InChI=1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
initial amount: NaN
name: UMP(2-)

http://identifiers.org/biomodels.db/MODEL1310110002#_a75b8966_ecbf_411c_8da9_14e2bc692380
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q9Y259
is encoded by: hsa:1120
initial amount: NaN
has only substance units: false
constant: false
name: CHKB

http://identifiers.org/biomodels.db/MODEL1310110002#_427bc117_957b_46ce_9fde_1616b4f54df4
type: Species
name: ALDH1B1
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:219
initial concentration: NaN
is: P30837
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_70348a8e_2452_4b29_80c9_2dd130cfc570
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: P00390
type: Species
initial concentration: NaN
is encoded by: hsa:2936
name: GSR
constant: false
has only substance units: false

metaR APOCF
fast: false
name: Apocarboxylase formation
is described by: ECO:0000000
kinetic law: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10191093 NOTES:IT faked reaction to balance reaction in human biotin metabolism
reactant: MODEL1310110002#
is: SBO:0000176
reversible: false

metaR ADEt
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000269
kinetic law: MODEL1310110002#
fast: false
reversible: true
name: adenine reversible transport, cytosol

http://identifiers.org/biomodels.db/MODEL1310110002#_f859229a_c4d3_4f9b_b5a2_579c5b87657f
constant: false
initial amount: NaN
is encoded by: hsa:2990
is: SBO:0000252
name: GUSB
has only substance units: false
is: P08236
initial concentration: NaN
boundary condition: true
type: Species

metaR DM fol
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Demand for folic aicd
type: Reaction

metaR HIBDm
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
reversible: true
notes: GENE_ASSOCIATION: (11112.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.1.1.31 Confidence Level: 4 AUTHORS: PMID:7527207 NOTES:MM
is described by: ECO:0000269
type: Reaction
product: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.31
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
fast: false

metaR q10h2tc
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
name: transport of ubiquinol into cytosol
product: MODEL1310110002#
fast: false
reversible: true

metaM amp c
initial amount: NaN
has only substance units: false
name: AMP
type: Species
is: SBO:0000247
initial concentration: 1.0
constant: false
is: HMDB00045
boundary condition: false
is: CHEBI:3322
notes: FORMULA: C10H12N5O7P CHARGE: -2
is: C00020

metaR r0578
modifier: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
reversible: true
is version of: http://identifiers.org/ec-code/4.1.2.27
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reactant: MODEL1310110002#
is: SBO:0000176
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110002#

metaR PRODt2r
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD SAB D form
type: Reaction
modifier: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
reversible: true
is described by: ECO:0000304
name: D-proline reversible transport via proton symport

metaM oaa m
constant: false
name: Oxaloacetate
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
type: Species
initial concentration: 1.0
is: HMDB00223
is: CHEBI:16452
is: C00036

metaM xtsn c
is: CHEBI:18107
boundary condition: false
has only substance units: false
is: HMDB00299
is: SBO:0000247
name: xanthosine
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_23c0546c_290b_484b_8ca3_da88b85ebd07
type: Species
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: TM7SF2
has only substance units: false
constant: false
is: O76062
is encoded by: hsa:7108

metaR r1632
type: Reaction
modifier: MODEL1310110002#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#

metaR CSEPASEly
is described by: ECO:0000000
reversible: false
is: SBO:0000176
product: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
fast: false
reactant: MODEL1310110002#
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)

metaM lnlncgcoa r
boundary condition: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
is: HMDB06368
constant: false
initial concentration: 1.0
name: gamma-linolenoyl-CoA(4-)
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:57363
type: Species

metaM mi13p c
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
is: CHEBI:18225
name: 1D-myo-Inositol 1,3-bisphosphate
type: Species
has only substance units: false
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
is: HMDB06234
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_c7a8c9c4_0237_43df_8547_73d579b9d701
constant: false
name: NOS3
boundary condition: true
type: Species
initial amount: NaN
is: A0S0A7
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4846
has only substance units: false

metaM leuktrD4 e
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial amount: NaN
name: Leukotriene D4
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:28666
is: HMDB03080

metaM o2 e
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
is: C00007
name: O2
boundary condition: false
type: Species
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: HMDB01377
is: CHEBI:15379

metaR NDPK10n
kinetic law: MODEL1310110002#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
is: SBO:0000176
product: MODEL1310110002#
is described by: ECO:0000304
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_e5e13c82_354f_4304_ab16_cb414cb106a6
initial amount: NaN
name: MANBA
is: SBO:0000252
is encoded by: hsa:4126
has only substance units: false
boundary condition: true
is: O00462
constant: false
type: Species
initial concentration: NaN

metaM 2mb2coa m
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h5,12-13,15,18-20,24,35-36H,6-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/b14-5+/t15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01102 EHMN_ABBREVIATION: C03345
type: Species
is: HMDB02054
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 2-methylcrotonoyl-CoA(4-)
boundary condition: false
is: CHEBI:57337

http://identifiers.org/biomodels.db/MODEL1310110002#_3ad5a46f_e3d8_4e8f_9330_7450c2ca3cf4
initial amount: NaN
type: Species
name: _BF195998_1_x
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:BF195998
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_ea7fce52_98a6_4d37_9dda_fbe7adba84a7
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:376497
type: Species
is: SBO:0000252
constant: false
name: SLC27A1
has only substance units: false

metaR DM Ser Gly Ala X Gly ly
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Ser-Gly/Ala-X-Gly(ly)
type: Reaction

metaM o2s c
type: Species
name: superoxide
boundary condition: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
is: CHEBI:18421
is: HMDB02168
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0

metaM ksi pre1 g
boundary condition: false
is: SBO:0000247
notes: FORMULA: C79H129N5O57X CHARGE: -1
initial amount: NaN
type: Species
name: keratan sulfate I biosynthesis, precursor 1
is: CHEBI:58053
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB00175
is: C00130

metaR r0579
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
type: Reaction
is version of: http://identifiers.org/ec-code/1.13.11.19
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
modifier: MODEL1310110002#
fast: false
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#

metaR FAOXC165C164m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaR CYTK6n
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reactant: MODEL1310110002#
name: cytidylate kinase (CMP,CTP),nuclear
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
is: SBO:0000176
modifier: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
type: Reaction

metaR RE0935E
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000
fast: false
type: Reaction
reactant: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0935
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
kinetic law: MODEL1310110002#
reversible: true
product: MODEL1310110002#
is: SBO:0000176

metaR ACHtn
is described by: ECO:0000000
product: MODEL1310110002#
is: SBO:0000185
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:it
name: Acetylcholin transport, nuclear trhough pores
fast: false
reversible: true
reactant: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_67b97a83_089a_425f_b066_799532f9e9b6
name: SGPL1
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:8879
is: O95470
boundary condition: true

metaR r2084
is described by: ECO:0000000
reactant: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110002#
is: SBO:0000185
fast: false
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
reversible: true

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaR r1631
fast: false
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reactant: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR GLCURter
name: glucuronate endoplasmic reticular transport
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: false
type: Reaction
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_b5cae765_1831_4dba_a943_f1b3d66e1486
type: Species
boundary condition: true
has only substance units: false
constant: false
name: PLCH1
is: Q4KWH8
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:23007
initial concentration: NaN

metaM HC01162 c
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
type: Species
boundary condition: false
is: CHEBI:58376
has only substance units: false
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate
is: SBO:0000247

metaR UMPK
is described by: ECO:0000269
name: UMP kinase
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110002#
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
fast: false

metaM lys L e
constant: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
is: CHEBI:32551
initial amount: NaN
name: L-lysinium(1+)
type: Species
initial concentration: 1.0
has only substance units: false

metaR ACHEe
product: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
name: Acetylcholinesterase
is version of: http://identifiers.org/ec-code/3.1.1.7
is described by: ECO:0000269
kinetic law: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
reversible: false
notes: GENE_ASSOCIATION: (43.1) or (43.2) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.1.7 Confidence Level: 4 AUTHORS: PMID:11283752,PMID:1517212 NOTES:NJ
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110002#_0def3235_727c_4f4a_81a7_9e4eb3063c1a
is: SBO:0000252
name: TSTA3
is: Q13630
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:7264
has only substance units: false
initial concentration: NaN

metaM ach n
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
type: Species
is: HMDB00895
initial amount: NaN
is: SBO:0000247
is: CHEBI:15355
has only substance units: false
constant: false
name: acetylcholine
initial concentration: 1.0
boundary condition: false

metaR GLCt4
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000185
type: Reaction
product: MODEL1310110002#
fast: false
is described by: ECO:0000269
name: glucose transport via sodium symport
reversible: true
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_be3c15b4_4bc2_4baf_a357_5c63bdafe670
boundary condition: true
is: SBO:0000252
constant: false
name: GCDH
is encoded by: hsa:2639
initial amount: NaN
type: Species
is: Q92947
initial concentration: NaN
has only substance units: false

metaM thym c
is: HMDB00262
is: CHEBI:17821
has only substance units: false
is: C00178
is: SBO:0000247
constant: false
initial concentration: 1.0
name: Thymine
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178

http://identifiers.org/biomodels.db/MODEL1310110002#_e0d8671c_3771_4098_98ce_6e08e9b7d3f1
constant: false
type: Species
is encoded by: hsa:2592
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is: B4E097
has only substance units: false
name: GALT
initial amount: NaN

metaR EX glyc S LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (S)-Glycerate exchange
type: Reaction

metaR r2085
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110002#
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
fast: false
reversible: true
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is: SBO:0000185

metaR r1630
is: SBO:0000185
reactant: MODEL1310110002#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110002#
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_693d3d76_9942_4eec_a3f6_2465250b842f
is: Q9NS82
type: Species
is encoded by: hsa:56301
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
name: SLC7A10
is: SBO:0000252
boundary condition: true

metaR B3GNT34g
is described by: ECO:0000269
reactant: MODEL1310110002#
product: MODEL1310110002#
reversible: false
kinetic law: MODEL1310110002#
fast: false
type: Reaction
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
is: SBO:0000176

metaM acnacngalgbside hs c
initial amount: NaN
is: HMDB00223
initial concentration: 1.0
constant: false
is: C00036
name: disialyl galactosylgloboside
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
is: CHEBI:3338
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species

metaR DASCBR
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
reactant: MODEL1310110002#
type: Reaction
fast: false
name: dehydroascorbate reductase
reversible: false
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.8.4.1
is: SBO:0000176
product: MODEL1310110002#
is described by: ECO:0000269
modifier: MODEL1310110002#

metaM leuktrD4 c
type: Species
is: SBO:0000247
name: Leukotriene D4
constant: false
is: HMDB03080
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: CHEBI:28666
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_77a2562c_566a_4ce3_9836_9da0163172f0
boundary condition: true
is: SBO:0000252
has only substance units: false
is: P27707
constant: false
is encoded by: hsa:1633
initial concentration: NaN
initial amount: NaN
name: DCK
type: Species

metaR r0149
type: Reaction
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.14.13.39
product: MODEL1310110002#
reversible: true
modifier: MODEL1310110002#
is described by: ECO:0000000

metaR PA HSter
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717 NOTES:
product: MODEL1310110002#
fast: false
type: Reaction
name: phosphatidate scramblase
kinetic law: MODEL1310110002#
reversible: true

metaR RE1897C
name: RE1897
is: SBO:0000176
reactant: MODEL1310110002#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110002#
reversible: true
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:

metaM o2 c
is: HMDB01377
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
name: O2
boundary condition: false
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007
is: C00007
type: Species
is: CHEBI:15379

http://identifiers.org/biomodels.db/MODEL1310110002#_e2108abc_9288_4d7f_8bd4_77a5d5c2b34d
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
name: MPST
type: Species
boundary condition: true
is: P25325
has only substance units: false
is encoded by: hsa:4357

metaR GLUTCOADHm
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.7
fast: false
modifier: MODEL1310110002#
name: glutaryl-CoA dehydrogenase (mitochondria)
reversible: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (2639.1) or (2639.2) SUBSYSTEM: Tryptophan metabolism EC Number: 1.3.99.7 Confidence Level: 2 AUTHORS: NOTES:SAB use of FAD is not certain
product: MODEL1310110002#
is described by: ECO:0000304

metaM e4p c
name: D-Erythrose 4-phosphate
is: SBO:0000247
is: C00279
constant: false
is: HMDB01321
type: Species
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
is: CHEBI:16897
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_fb87915a_d7bd_4dd5_a519_fee9a1e587d7
name: SLC9A2
initial concentration: NaN
boundary condition: true
is: SBO:0000252
type: Species
is: Q9UBY0
is encoded by: hsa:6549
initial amount: NaN
has only substance units: false
constant: false

metaR GARFT
type: Reaction
reactant: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.1.2.2
kinetic law: MODEL1310110002#
reversible: true
product: MODEL1310110002#
name: phosphoribosylglycinamide formyltransferase
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.2 Confidence Level: 4 AUTHORS: PMID:12450384,PMID:2183217,PMID:9328467,PMID:9473452 NOTES:
is: SBO:0000176

metaR NAGAlby
reactant: MODEL1310110002#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 1 AUTHORS: NOTES:Beta-galactosidase B - no evidence to support this actually happens yet; added by analogy with alpha-galactosidase B (NAGAIy) NJ
product: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
name: N-acetylgalactosaminidase, beta-
type: Reaction
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110002#_3fd3e85e_af9d_47d4_bf1d_c0afd168cc26
has only substance units: false
name: NDUFV3
type: Species
is: P56181
is encoded by: hsa:4731
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true

metaM acgam l
is: HMDB00215
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:17411
initial amount: NaN
is: SBO:0000247
type: Species
name: N-acetyl-D-glucosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial concentration: 1.0

metaM lys L c
is: SBO:0000247
is: HMDB00182
has only substance units: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
type: Species
is: CHEBI:32551
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
name: L-lysinium(1+)

http://identifiers.org/biomodels.db/MODEL1310110002#_c4090d61_8fa3_47ba_aa6f_93be521be724
is: SBO:0000252
type: Species
initial amount: NaN
name: AK5
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:26289
boundary condition: true

metaR r2086
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
type: Reaction
modifier: MODEL1310110002#
is described by: ECO:0000000
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_5b4ea941_33c0_4f0d_9412_3c1c0bdb803c
is encoded by: hsa:5052
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: PRDX1
constant: false

metaR r1497
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076396,PMID:11819755,PMID:17404808,PMID:6384004 NOTES:
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter TCDB:2.A.28.1.1
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
fast: false
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110002#_db9fec3e_76f8_487a_bcc1_fccd47ccd777
is: GO:0005783
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: endoplasmic reticulum
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110002#_447e48e9_c131_4133_9197_c571ca29b2d6
is: SBO:0000252
initial amount: NaN
constant: false
name: RDH13
initial concentration: NaN
is: B3KVA3
boundary condition: true
is encoded by: hsa:112724
has only substance units: false
type: Species

metaM ach c
initial amount: NaN
has only substance units: false
type: Species
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
name: acetylcholine
constant: false
is: SBO:0000247
is: CHEBI:15355
boundary condition: false
is: HMDB00895
initial concentration: 1.0

metaR FATP3t
name: fatty acid electroneutral transport
reactant: MODEL1310110002#
is described by: ECO:0000269
is: SBO:0000185
fast: false
product: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_c9360163_252b_42c0_8e64_abc252ed8465
boundary condition: true
name: PRDX1
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:5052
constant: false
is: SBO:0000252

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaR r2087
is: SBO:0000185
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_f0267e6e_dced_44a5_bad0_1dca28e75e00
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
boundary condition: true
is: O14986
is encoded by: hsa:8395
name: PIP5K1B
has only substance units: false
is: SBO:0000252

metaR r2525
type: Reaction
is: SBO:0000185
product: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
fast: false
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_7d7771b6_722d_410f_a0a4_8fc4b7e65a21
initial amount: NaN
constant: false
name: FUT8
boundary condition: true
is: SBO:0000252
initial concentration: NaN
is: Q546E0
has only substance units: false
is encoded by: hsa:2530
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_f397a478_d81c_4aac_a803_98e27420b1dc
has only substance units: false
initial amount: NaN
is: P22392
constant: false
type: Species
name: NME2
is: SBO:0000252
boundary condition: true
is encoded by: hsa:4831
initial concentration: NaN

metaR TRDR
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
product: MODEL1310110002#
is: SBO:0000176
name: thioredoxin reductase (NADPH)
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.9
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110002#
reactant: MODEL1310110002#

metaR BILGLCURtr
name: glucuronidated compound transport
reversible: true
is: SBO:0000185
product: MODEL1310110002#
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
reactant: MODEL1310110002#
is described by: ECO:0000000
type: Reaction

metaM ppa e
constant: false
is: HMDB00237
is: SBO:0000247
initial amount: NaN
type: Species
name: propionate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
is: CHEBI:17272
boundary condition: false

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaR GGH 7DHFe
fast: false
is described by: ECO:0000000
name: Gamma-glutamyl hydrolase (7DHF), extracellular
kinetic law: MODEL1310110002#
is: SBO:0000176
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
modifier: MODEL1310110002#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110002#_4df22316_522d_4102_a962_63e300ab52f3
initial concentration: NaN
is: SBO:0000252
boundary condition: true
name: _R06874_1_r
type: Species
has only substance units: false
is encoded by: hsa:R06874
constant: false
initial amount: NaN

metaM ump c
has only substance units: false
name: UMP
is: HMDB00288
initial amount: NaN
is: SBO:0000247
constant: false
type: Species
boundary condition: false
is: C00105
notes: FORMULA: C9H11N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00105 EHMN_ABBREVIATION: C00105
is: CHEBI:57865
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110002#_3637e7c0_b59a_4fc5_ba6f_79ecbf79b559
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
constant: false
name: _LOC728997_1_c
is encoded by: hsa:LOC728997

metaM r5p c
has only substance units: false
initial amount: NaN
is: HMDB00618
name: alpha-D-Ribose 5-phosphate
is: SBO:0000247
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00115 EHMN_ABBREVIATION: C00117
boundary condition: false
is: C00117
initial concentration: 1.0
constant: false
is: CHEBI:18189
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_9564fc0f_83ec_42cc_93c0_ac7d8fac1d07
is encoded by: hsa:6319
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
is: O00767
constant: false
boundary condition: true
name: SCD
initial concentration: NaN

metaM i e
initial amount: NaN
type: Species
notes: FORMULA: I CHARGE: -1 INCHI: InChI=1S/HI/h1H/p-1 EHMN_ABBREVIATION: C00708
is: HMDB12238
is: CHEBI:16382
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: iodide

metaM aicar e
is: SBO:0000247
constant: false
is: CHEBI:58475
notes: FORMULA: C9H13N4O8P CHARGE: -2
is: HMDB01517
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
initial concentration: 1.0
has only substance units: false
type: Species
is: C04677
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_84434706_b703_4b9c_a43f_3d2f3a6783f9
has part: Q9NS82
has part: P08195
name: SLC7A10:SLC3A2
has only substance units: false
constant: false
is encoded by: hsa:6520
is encoded by: hsa:56301
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000297
type: Species

metaR EX ach LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetylcholine exchange
type: Reaction

metaR r2088
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110002#
is: SBO:0000185
modifier: MODEL1310110002#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
type: Reaction
is described by: ECO:0000000

metaR EX 5mthf LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 5-Methyltetrahydrofolate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_7ec81750_ee08_4885_8039_65f7ed9bdf3f
initial concentration: NaN
initial amount: NaN
has only substance units: false
is encoded by: hsa:AI656480
boundary condition: true
constant: false
type: Species
is: SBO:0000252
name: _AI656480_1_m

metaR EX prostge1 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin E1 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_bf02a88c_2f96_4e61_b297_3ea72ab4cb7f
is encoded by: hsa:79053
type: Species
is: SBO:0000252
name: ALG8
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN

metaR CYOOm3
product: MODEL1310110002#
reversible: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (1351.1) and (1347.1) and (1329.1) and (1327.1) and (341947.1) and (9167.1) and (1350.1) and (4512.1) and (1349.1) and (1339.1) and (1345.1) and (4513.1) and (9377.1) and (125965.1) and (4514.1) and (170712.1) and (1346.1) and (1340.1) and (84701.1) and (1337.1) SUBSYSTEM: Oxidative phosphorylation EC Number: Confidence Level: 4 AUTHORS: PMID:10869362,PMID:12241082 NOTES:TV, 2% O2 lost in O2-
name: cytochrome c oxidase, mitochondrial Complex IV
is: SBO:0000185
fast: false
reactant: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
is version of: http://identifiers.org/ec-code/1.9.3.1
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110002#_2b111d6e_f63c_4236_aa64_5edb7c2387d3
is: O75747
name: PIK3C2G
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
is encoded by: hsa:5288
boundary condition: true
constant: false
initial concentration: NaN

metaR UAGALDP
name: UDP-N-acetylgalactosamine diphosphorylase
is described by: ECO:0000000
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110002#_6309e451_3b31_4486_b169_f5ed5f05da39
initial amount: NaN
name: PPAP2A
is: G3XA95
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:8611
has only substance units: false

metaM HC00250 e
name: hydrosulfide
is: CHEBI:29919
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
constant: false
initial concentration: 1.0

metaR MACACI
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
fast: false
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
name: maleylacetoacetate isomerase
is version of: http://identifiers.org/ec-code/2.5.1.18
reversible: false
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_8fed33e6_c15e_4ef1_b89e_b02fdec48a4e
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:57282
constant: false
is: B7Z1R0
is: SBO:0000252
name: SLC4A10

metaM mal L x
name: (S)-malate(2-)
boundary condition: false
constant: false
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1
is: SBO:0000247
initial concentration: 1.0
type: Species
is: HMDB00156
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110002#_f088616d_d857_4b2a_868a_e22def4db13d
constant: false
is encoded by: hsa:57835
has only substance units: false
boundary condition: true
is: Q9BY07
name: SLC4A5
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110002#_af870bf8_9d89_4c5c_ac83_3d037ad64dac
is: Q9HCQ5
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:50614
initial amount: NaN
constant: false
initial concentration: NaN
name: GALNT9

metaM orot5p c
is: CHEBI:57538
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C10H10N2O11P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00669 EHMN_ABBREVIATION: C01103
constant: false
name: Orotidine 5'-phosphate
is: HMDB00218
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: C01103

http://identifiers.org/biomodels.db/MODEL1310110002#_da3b4a33_a6e6_4fd8_a16d_6400ad2d725a
initial amount: NaN
name: MGAT1
type: Species
initial concentration: NaN
is: P26572
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:4245
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_9bbc2e3f_78c6_466d_8cd7_2c1064635f83
constant: false
is encoded by: hsa:728637
name: _728637_1_c
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true

metaR GGH 6DHFe
is version of: http://identifiers.org/ec-code/3.4.19.9
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
product: MODEL1310110002#
reactant: MODEL1310110002#
name: Gamma-glutamyl hydrolase (6DHF), extracellular
reversible: false
fast: false
modifier: MODEL1310110002#
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110002#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110002#_7a454077_0c7d_40b2_b0d5_433f176e17e7
is encoded by: hsa:4701
type: Species
initial amount: NaN
constant: false
is: Q6FG42
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: NDUFA7
has only substance units: false

metaR DGULND
product: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
reversible: true
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is: SBO:0000176
name: dehydro-L-gulonate decarboxylase
type: Reaction
fast: false

metaR KSII CORE4tly
type: Reaction
name: keratan sulfate II (core 4) transport, extracellular to lysosome
product: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
fast: false
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

metaR r2089
product: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110002#
fast: false
modifier: MODEL1310110002#
is: SBO:0000185
type: Reaction
reversible: true

metaR KYNAKGAT
modifier: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.6.1.64
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.6.1.7
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
name: L-Kynurenine:2-oxoglutarate aminotransferase
type: Reaction
fast: false

metaR CRNCARtp
reactant: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: false
is: SBO:0000185
type: Reaction
name: carnitine-acetylcarnitine carrier, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
fast: false

metaM gdpfuc c
name: GDP-L-fucose(2-)
is: CHEBI:57984
initial amount: NaN
constant: false
is: HMDB01095
type: Species
has only substance units: false
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

metaM prpncoa m
initial amount: NaN
constant: false
boundary condition: false
is: SBO:0000247
name: acryloyl-CoA(4-)
type: Species
notes: FORMULA: C24H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C24H38N7O17P3S/c1-4-15(33)52-8-7-26-14(32)5-6-27-22(36)19(35)24(2,3)10-45-51(42,43)48-50(40,41)44-9-13-18(47-49(37,38)39)17(34)23(46-13)31-12-30-16-20(25)28-11-29-21(16)31/h4,11-13,17-19,23,34-35H,1,5-10H2,2-3H3,(H,26,32)(H,27,36)(H,40,41)(H,42,43)(H2,25,28,29)(H2,37,38,39)/p-4/t13-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00579 EHMN_ABBREVIATION: C00894
is: HMDB02307
initial concentration: 1.0
has only substance units: false
is: CHEBI:57367

http://identifiers.org/biomodels.db/MODEL1310110002#_fff4bf0b_c78c_452a_bf90_d6de727a29a9
initial concentration: NaN
is encoded by: hsa:83594
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: NUDT12
is: SBO:0000252
boundary condition: true
is: Q9BQG2

metaR EX thym LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymine exchange
type: Reaction

metaR AMETr
fast: false
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NJ
is: SBO:0000185
product: MODEL1310110002#
name: S-Adenosyl-L-methionine intracellular diffusion
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000

metaR EX gsn LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Guanosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_0a627863_9b48_49ac_bdaf_8468db1d0b20
initial concentration: NaN
initial amount: NaN
name: PCBD2
type: Species
boundary condition: true
is: SBO:0000252
is: Q9H0N5
is encoded by: hsa:84105
constant: false
has only substance units: false

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR NP1
fast: false
is described by: ECO:0000304
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
modifier: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: NAD metabolism EC Number: 3.4.2.1 Confidence Level: 2 AUTHORS: NOTES:NCD
name: nucleotide phosphatase
is: SBO:0000176
reversible: false

metaM ppa c
is: CHEBI:17272
name: propionate
constant: false
type: Species
is: HMDB00237
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
boundary condition: false

metaR NAGLCAly
is: SBO:0000176
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
reversible: false
type: Reaction
product: MODEL1310110002#
is described by: ECO:0000000
fast: false
name: N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 1 AUTHORS: NOTES:EC 3.2.1.- This reaction is my best guess at how the GlcNAc-beta-1,6-GalNAc linkage is cleaved. NCD

metaM xyl D l
name: aldehydo-D-xylose
type: Species
boundary condition: false
is: CHEBI:15936
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR LDH L
name: L-lactate dehydrogenase
is described by: ECO:0000000
kinetic law: MODEL1310110002#
fast: false
modifier: MODEL1310110002#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.27
product: MODEL1310110002#
reactant: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
type: Reaction

metaR BDHm
modifier: MODEL1310110002#
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
is described by: ECO:0000269
fast: false
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
is: SBO:0000176
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/1.1.1.30

metaM air c
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C8H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01108 EHMN_ABBREVIATION: C03373
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole
initial amount: NaN
is: CHEBI:58592
constant: false
is: HMDB01235
type: Species
is: C03373

metaM aicar c
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: C04677
initial amount: NaN
is: CHEBI:58475
is: SBO:0000247
constant: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
initial concentration: 1.0
has only substance units: false
is: HMDB01517
type: Species
boundary condition: false

metaM CE5854 e
is: SBO:0000247
is: CHEBI:27485
type: Species
initial concentration: 1.0
name: gama-CEHC-glucuronide
boundary condition: false
is: HMDB02710
has only substance units: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
constant: false
initial amount: NaN

metaM ksi g
is: SBO:0000247
type: Species
has only substance units: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00189
is: CHEBI:57614
name: keratan sulfate I
constant: false

metaR G14T16g
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110002#
is: SBO:0000176
type: Reaction
reversible: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000000
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi

metaR EX gbside hs LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: globoside (homo sapiens) exchange
type: Reaction

metaR URIt5le
type: Reaction
reversible: false
name: uridine transport in via sodium symport (1:2)
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110002#
is described by: ECO:0000134
modifier: MODEL1310110002#

metaR MALtm
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
modifier: MODEL1310110002#
fast: false
name: malate transport, mitochondrial
reactant: MODEL1310110002#
is: SBO:0000185
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: true

metaM pap c
has only substance units: false
type: Species
is: CHEBI:58343
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00061
name: adenosine 3',5'-bismonophosphate(4-)
is: SBO:0000247

metaM ksi pre9 g
has only substance units: false
is: C00130
constant: false
is: HMDB00175
initial concentration: 1.0
type: Species
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 9
boundary condition: false
notes: FORMULA: C121H196N8O93S2X CHARGE: -3
is: SBO:0000247
initial amount: NaN

metaR PETOHMr hs
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.1.17
modifier: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-Prot] NJ
name: phosphatidylethanolamine N-methyltransferase
type: Reaction
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reversible: false
fast: false

metaR UMPK2n
modifier: MODEL1310110002#
reversible: true
product: MODEL1310110002#
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
name: UMP kinase (CTP),nuclear
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction

metaR SUCOASm
reactant: MODEL1310110002#
is version of: http://identifiers.org/ec-code/6.2.1.5
is described by: ECO:0000000
product: MODEL1310110002#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.4
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.5 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:MIPS: cofactor ATP IF changed EC from 6.2.1.4 to 6.2.1.5 - NCD
is: SBO:0000176
type: Reaction
name: Succinate--CoA ligase (ADP-forming)
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#

metaR r2526
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110002#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185

metaM amp m
name: AMP(2-)
initial concentration: 1.0
is: CHEBI:456215
is: SBO:0000247
type: Species
is: HMDB00045
constant: false
has only substance units: false
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110002#_c8164811_66c1_4ff8_acf5_4762d822ac9e
initial amount: NaN
is encoded by: hsa:217
has only substance units: false
constant: false
initial concentration: NaN
is: P05091
boundary condition: true
is: SBO:0000252
name: ALDH2
type: Species

metaR ALAGLNexR
type: Reaction
reversible: true
reactant: MODEL1310110002#
is described by: ECO:0000304
fast: false
name: L-alanine/glutamine reversible exchange
is: SBO:0000185
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (6520.1) and (56301.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#

metaR EX ha pre1 LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: hyaluronan biosynthesis, precursor 1 exchange
type: Reaction

metaR FUT99g
reversible: false
notes: GENE_ASSOCIATION: (10690.1) SUBSYSTEM: Blood group synthesis EC Number: 2.4.1.152 Confidence Level: 4 AUTHORS: PMID:10386598 NOTES:NJ
reactant: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.4.1.152
is described by: ECO:0000269
fast: false
type: Reaction
product: MODEL1310110002#
modifier: MODEL1310110002#
name: Alpha-(1,3)-fucosyltransferase

metaR NTD1m
notes: GENE_ASSOCIATION: (56953.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 4 AUTHORS: PMID:10899995 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
fast: false
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
modifier: MODEL1310110002#
is described by: ECO:0000269
is: SBO:0000176
reversible: false
type: Reaction
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/3.1.3.5
name: 5'-nucleotidase (dUMP),mitochondrial

metaM HC00250 c
type: Species
is: CHEBI:29919
name: hydrosulfide
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_0e2dabd7_faa0_41cc_af18_f90b8687c050
initial concentration: NaN
constant: false
name: PIP4K2C
has only substance units: false
is: SBO:0000252
is encoded by: hsa:79837
initial amount: NaN
type: Species
is: B3KQV3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_153c6c89_5b8f_4f24_83b8_44596a3f5172
constant: false
initial amount: NaN
name: GALK2
has only substance units: false
is: SBO:0000252
is: Q01415
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:2585

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_43805ed6_dcc8_49f2_83ad_97663ad264a6
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: PRPS1L1
initial concentration: NaN
is encoded by: hsa:221823
has only substance units: false
constant: false
is: P21108
type: Species

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110002#_d3b64235_741d_45f9_bbc5_c19a66b98f13
initial concentration: NaN
is: Q8NFF5
constant: false
is: SBO:0000252
name: FLAD1
type: Species
boundary condition: true
initial amount: NaN
is encoded by: hsa:80308
has only substance units: false

metaR CRNtHa
kinetic law: MODEL1310110002#
product: MODEL1310110002#
notes: GENE_ASSOCIATION: (6583.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB H+ stoichiometry unknown
reversible: false
modifier: MODEL1310110002#
is described by: ECO:0000269
reactant: MODEL1310110002#
name: L-carnitine outward transport (H+ antiport)
type: Reaction
is: SBO:0000185
fast: false

metaM ppi m
is: C00013
initial concentration: 1.0
has only substance units: false
name: Diphosphate
constant: false
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: HMDB00250
boundary condition: false
initial amount: NaN
type: Species
is: CHEBI:33019
is: SBO:0000247

metaR r0142
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.6.1.5
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
reactant: MODEL1310110002#
product: MODEL1310110002#
modifier: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
reversible: false

metaR r1493
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:15845416 NOTES:
is described by: ECO:0000000
reversible: false
product: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
fast: false
is: SBO:0000185
name: Utilized transport
kinetic law: MODEL1310110002#

metaM 34dhmald m
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
is: http://identifiers.org/pubchem.compound/7903
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: 3,4-Dihydroxymandelaldehyde
type: Species
is: SBO:0000247
is: C05577
is: HMDB06242
constant: false
initial amount: NaN

metaR r1527
is version of: http://identifiers.org/ec-code/4.2.1.1
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
reactant: MODEL1310110002#
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110002#
kinetic law: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000185
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1

http://identifiers.org/biomodels.db/MODEL1310110002#_f634ee59_144b_456d_b9d7_74995d298e94
is encoded by: hsa:10637
is: SBO:0000252
initial amount: NaN
name: LEFTY1
boundary condition: true
initial concentration: NaN
type: Species
is: O75610
constant: false
has only substance units: false

metaM uri e
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
name: Uridine
initial concentration: 1.0
is: C00299
has only substance units: false
is: SBO:0000247
is: CHEBI:16704
type: Species
constant: false
initial amount: NaN
is: HMDB00296
boundary condition: false

metaM ura c
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:17568
boundary condition: false
is: C00106
name: Uracil
type: Species
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: HMDB00300
initial amount: NaN
has only substance units: false

metaR GLXtp
product: MODEL1310110002#
is described by: ECO:0000000
reactant: MODEL1310110002#
name: glyoxylate transport, peroxisomal
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
kinetic law: MODEL1310110002#
type: Reaction
fast: false
is: SBO:0000185

metaM HC02204 c
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:27624
boundary condition: false
has only substance units: false
type: Species
initial concentration: 1.0
name: prostaglandin-b1

http://identifiers.org/biomodels.db/MODEL1310110002#_22ffa7f1_d2d5_4d70_a908_6fcd023e0584
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: FUT8
is: A8K8P8
is: SBO:0000252
constant: false
is encoded by: hsa:2530
type: Species

http://identifiers.org/biomodels.db/MODEL1310110002#_f819d83a_6ba0_44f0_a6ac_e5b8f7bdebda
boundary condition: true
name: PC
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is: P11498
is encoded by: hsa:5091

metaR DUTPDPn
is version of: http://identifiers.org/ec-code/3.6.1.23
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:
reactant: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
fast: false
reversible: false
name: dUTP diphosphatase, nuclear
type: Reaction
modifier: MODEL1310110002#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110002#_916a753a_82e6_48c9_9d0b_76af1c28f672
initial concentration: NaN
constant: false
is: Q96C36
initial amount: NaN
is: SBO:0000252
name: PYCR2
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:29920

metaR r1377
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.4.1.22 Confidence Level: 0 AUTHORS: NOTES:
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110002#
kinetic law: MODEL1310110002#
is described by: ECO:0000000
name: S-(hydroxymethyl)glutathione synthase Methane metabolism EC:4.4.1.22
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_e
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: C00095
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
initial amount: NaN
is: HMDB00660
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
is: CHEBI:15824
type: Species

metaM ksi e
name: keratan sulfate I
initial amount: NaN
boundary condition: false
has only substance units: false
is: HMDB00211
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: SBO:0000247
constant: false
is: CHEBI:17268
initial concentration: 1.0
type: Species

metaM ppcoa c
boundary condition: false
initial amount: NaN
is: CHEBI:57392
constant: false
initial concentration: 1.0
is: HMDB01275
has only substance units: false
type: Species
name: Propanoyl-CoA
is: SBO:0000247
notes: FORMULA: C24H36N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00101 EHMN_ABBREVIATION: C00100
is: C00100

metaM ak2lgchol hs c
type: Species
is: http://identifiers.org/pubchem.compound/6975
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H21O5NPFULLR CHARGE: 0 EHMN_ABBREVIATION: C04317
is: C04317
name: 1-alkyl 2-lysoglycerol 3-phosphocholine
initial amount: NaN

metaR ABO4g
is described by: ECO:0000269
product: MODEL1310110002#
reactant: MODEL1310110002#
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.37
notes: GENE_ASSOCIATION: (28.1) SUBSYSTEM: Blood group synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11421346,PMID:12198488,PMID:2121736 NOTES:NJ
name: ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
kinetic law: MODEL1310110002#
is: SBO:0000176
reversible: false
modifier: MODEL1310110002#

metaM ppi n
constant: false
is: CHEBI:33019
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00250
type: Species
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3 INCHI: InChI=1S/H4O7P2/c1-8(2,3)7-9(4,5)6/h(H2,1,2,3)(H2,4,5,6)/p-3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
name: diphosphate(3-)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_3df218ce_4f65_4a54_b49c_ec29746402f7
constant: false
name: ST3GAL2
is: SBO:0000252
initial amount: NaN
is: Q16842
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6483
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_galacgalfuc12gal14acglcgalgluside_hs_g
has only substance units: false
boundary condition: false
is: CHEBI:26174
initial amount: NaN
notes: FORMULA: C64H112N3O36FULLRCO CHARGE: 0
initial concentration: 1.0
type: Species
is: SBO:0000247
name: (Gal)3 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)1 (Cer)1
constant: false

metaR MCLACCYSR
kinetic law: MODEL1310110002#
fast: false
is described by: ECO:0000000
name: 3-mercaptolactate:cysteine reductase
product: MODEL1310110002#
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
is: SBO:0000176
reversible: false
type: Reaction

metaR r1639
modifier: MODEL1310110002#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110002#
product: MODEL1310110002#
type: Reaction
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM lys L m
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
type: Species
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
name: L-lysinium(1+)
is: HMDB00182

http://identifiers.org/biomodels.db/MODEL1310110002#_61215d5e_3b9d_45d9_a8f2_7a1714d3e532
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:5051
has only substance units: false
type: Species
is: SBO:0000252
name: PAFAH2
is: Q99487
constant: false

metaR NDPK9n
fast: false
modifier: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
is described by: ECO:0000269
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
is: SBO:0000176
kinetic law: MODEL1310110002#
reversible: true
product: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.4.6
reactant: MODEL1310110002#

metaR NTD6
is version of: http://identifiers.org/ec-code/3.1.3.5
modifier: MODEL1310110002#
product: MODEL1310110002#
is: SBO:0000176
kinetic law: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
reversible: false
fast: false
name: 5'-nucleotidase (dAMP)
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:8450671 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31
type: Reaction

metaM o2 m
boundary condition: false
constant: false
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB01377
is: CHEBI:15379
initial amount: NaN
is: C00007
name: O2
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00017 EHMN_ABBREVIATION: C00007

metaR PAPtg
name: adenosine 3',5'-bisphosphate Golgi transport
is described by: ECO:0000000
reactant: MODEL1310110002#
product: MODEL1310110002#
kinetic law: MODEL1310110002#
reversible: false
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false

W3 CDTF: Fri Aug 31 01:35:31 BST 2012

http://identifiers.org/biomodels.db/MODEL1310110002#_a3d5bc52_746b_4722_9b9e_cefe1b7b035d
type: Species
boundary condition: true
initial concentration: NaN
is: B7Z5T8
initial amount: NaN
is encoded by: hsa:1375
has only substance units: false
is: SBO:0000252
name: CPT1B
constant: false

metaR r1374
type: Reaction
is described by: ECO:0000000
reversible: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
reactant: MODEL1310110002#
kinetic law: MODEL1310110002#
is: SBO:0000176
name: EC:3.2.1.14
fast: false

metaM CE5119 m
name: trans-3-cis-8-tetradecadienoyl-CoA
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:57923
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
initial amount: NaN
is: SBO:0000247
boundary condition: false

metaR RBFK
product: MODEL1310110002#
name: riboflavin kinase
is: SBO:0000176
reactant: MODEL1310110002#
is described by: ECO:0000269
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
type: Reaction
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.26
reversible: false

metaM ac c
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: acetate
is: SBO:0000247
is: CHEBI:30089
has only substance units: false
boundary condition: false
is: HMDB00042

metaM 13dampp c
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
is: HMDB00002
boundary condition: false
constant: false
is: CHEBI:57484
initial concentration: 1.0
has only substance units: false
name: trimethylenediaminium
is: SBO:0000247
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110002#_7dd94f8e_4c0a_485b_a707_9a1767bfe155
constant: false
is: SBO:0000297
has part: Q8WYR1
is encoded by: hsa:23533
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: PIK3R5:PIK3CG

metaM acgam c
type: Species
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial concentration: 1.0
is: HMDB00215
has only substance units: false
is: SBO:0000247
name: N-acetyl-D-glucosamine
initial amount: NaN
is: CHEBI:17411
boundary condition: false
constant: false

metaR DHPR2
is described by: ECO:0000304
fast: false
reversible: false
is: SBO:0000176
product: MODEL1310110002#
kinetic law: MODEL1310110002#
type: Reaction
reactant: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3735413 NOTES:IT
name: 6,7-dihydropteridine reduction

metaM uri c
initial amount: NaN
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
initial concentration: 1.0
is: HMDB00296
has only substance units: false
is: C00299
is: CHEBI:16704
type: Species
is: SBO:0000247
boundary condition: false
name: Uridine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_9167eb93_e7cb_4207_98f4_7aeef30cf6f0
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
name: NDUFS2
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:4720
is: B7Z792

metaR r0249
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
reactant: MODEL1310110002#
type: Reaction
is: SBO:0000176
product: MODEL1310110002#
is described by: ECO:0000000
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
reversible: true
fast: false
kinetic law: MODEL1310110002#
modifier: MODEL1310110002#
is version of: http://identifiers.org/ec-code/2.7.7.12

W3 CDTF: Fri Aug 31 01:35:31 BST 2012

metaR r1638
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110002#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
modifier: MODEL1310110002#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110002#
product: MODEL1310110002#

http://identifiers.org/biomodels.db/MODEL1310110002#_0a83303e_163f_4594_a33b_c3612ef221d8
is encoded by: hsa:4953
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
name: ODC1
is: P11926
constant: false
initial concentration: NaN
is: SBO:0000252

metaM acac x
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: HMDB00060
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: acetoacetate
type: Species
constant: false
is: CHEBI:13705

http://identifiers.org/biomodels.db/MODEL1310110002#_d44dbb99_e9f5_40a5_a20d_9eb66dfb0a0f
type: Species
initial concentration: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AL048840
initial amount: NaN
boundary condition: true
name: _AL048840_1_c
constant: false

metaR 2HBt2
fast: false
modifier: MODEL1310110002#
product: MODEL1310110002#
is described by: ECO:0000269
kinetic law: MODEL1310110002#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
name: 2-hydroxybutyrate cotransport with proton
reactant: MODEL1310110002#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110002#_a9dbd14f_e413_416d_9e23_33bad22e38f7
name: PLCG1
is: P19174
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:5335

http://identifiers.org/biomodels.db/MODEL1310110002#_ecad8a62_aad1_481e_93c9_02ee33b3d2a7
constant: false
type: Species
is encoded by: hsa:51809
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: GALNT7
is: SBO:0000252
is: Q86SF2
has only substance units: false

metaM HC02204 e
initial amount: NaN
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: SBO:0000247
is: CHEBI:27624
boundary condition: false
type: Species
has only substance units: false
initial concentration: 1.0
name: prostaglandin-b1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110002#_dc7081b8_bc4c_4100_8930_a75de6d1ee9b
has only substance units: false
constant: false
is: O15244
initial amount: NaN
type: Species
is encoded by: hsa:6582
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SLC22A2

http://identifiers.org/biomodels.db/MODEL1310110002#_metaM_fucfucfucgalacglc13galacglcgal14acglcgalgluside_hs_g
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
initial amount: NaN
has only substance units: false
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)3 (Cer)1
notes: FORMULA: C90H155N4O54FULLRCO CHARGE: 0
is: CHEBI:18287
type: Species
is: HMDB00174

metaR r1375
fast: false
is: SBO:0000185
reversible: false
product: MODEL1310110002#
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:17267599 NOTES:
type: Reaction
reactant: MODEL1310110002#
name: Transport reaction
is described by: ECO:0000000
kinetic law: MODEL1310110002#

metaR FAOXC142C122m
kinetic law: MODEL1310110002#
product: MODEL1310110002#
reactant: MODEL1310110002#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction