metaM thcrm hs g
name: trihexosyl ceramide
is: SBO:0000247
notes: FORMULA: C36H66NO17FULLRCO CHARGE: 0
constant: false
is: CHEBI:24636
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_7d8b4dfe_cad5_427c_b7e3_c41195dbffca
is encoded by: hsa:641649
initial concentration: NaN
type: Species
initial amount: NaN
is: C9JZ62
is: SBO:0000252
has only substance units: false
name: TMEM91
constant: false
boundary condition: true

metaR FAOXC183806m
is version of: http://identifiers.org/ec-code/1.3.99.3
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176
type: Reaction
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 3 degrees loss of saturation -> only 2 fad oxidized to fadh2 - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c18:3,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is described by: ECO:0000269
reversible: false
name: Beta oxidation of fatty acid
fast: false

metaR S6TASE12ly
fast: false
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
type: Reaction
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
is described by: ECO:0000000

metaR r0281
product: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
name: Putrescine:oxygen oxidoreductase (deaminating) Urea cycle and metabolism of amino groups EC:1.4.3.6
is version of: http://identifiers.org/ec-code/5.3.1.6
notes: GENE_ASSOCIATION: (22934.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:12072962,PMID:15795708,PMID:17006978,PMID:6403048 NOTES:
type: Reaction
is: SBO:0000176
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
is described by: ECO:0000000

metaM tetdece1crn e
constant: false
name: tetradecenoyl carnitine
is: SBO:0000247
notes: FORMULA: C21H39NO4 CHARGE: 0
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB02014
initial amount: NaN
boundary condition: false

metaM cgly c
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
type: Species
is: HMDB00078
has only substance units: false
initial amount: NaN
is: CHEBI:4047
name: L-cysteinylglycine

metaM Sfglutth c
name: S-formylglutathionate(1-)
has only substance units: false
constant: false
is: CHEBI:57688
boundary condition: false
initial amount: NaN
notes: FORMULA: C11H16N3O7S CHARGE: -1 INCHI: InChI=1S/C11H17N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h5-7H,1-4,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C01031
is: HMDB01550
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_31b5c17a_5b1d_4d12_bf76_f0def2bb47f5
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
name: PIK3R5
is: Q8WYR1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:23533
has only substance units: false

metaR r2125
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
reversible: true
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110001#
modifier: MODEL1310110001#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_927df858_dfc7_4efa_ab09_da79768ccab2
initial amount: NaN
boundary condition: true
is encoded by: hsa:6470
constant: false
is: SBO:0000252
is: P34896
name: SHMT1
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_bd069f68_b9aa_4128_a38c_3bda6fbf6a5e
is encoded by: hsa:501
boundary condition: true
initial amount: NaN
name: ALDH7A1
constant: false
type: Species
is: E7EPT3
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM dcyt n
boundary condition: false
is: CHEBI:15698
is: HMDB00014
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C9H13N3O4 CHARGE: 0 INCHI: InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: SBO:0000247
name: 2'-deoxycytidine

http://identifiers.org/biomodels.db/MODEL1310110001#_faa7362a_81e0_4119_9eca_2ab4310b6ea7
initial concentration: NaN
boundary condition: true
is encoded by: hsa:51
constant: false
initial amount: NaN
is: B4DK61
has only substance units: false
type: Species
is: SBO:0000252
name: ACOX1

metaR PPItr
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
fast: false
is: SBO:0000185
name: Diphosphate transporter, endoplasmic reticulum
reactant: MODEL1310110001#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_d5a81713_c71e_4869_85b8_e47f306052b1
initial concentration: NaN
has only substance units: false
name: ACP2
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
constant: false
is: E9PCI1
is encoded by: hsa:53

http://identifiers.org/biomodels.db/MODEL1310110001#_ab5f99ca_024a_4fad_90b7_3ec7f90d7ea5
boundary condition: true
name: ATP5C1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
is: P36542
constant: false
is encoded by: hsa:509
has only substance units: false

metaM hx2coa m
is: C05998
initial concentration: 1.0
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
type: Species
name: trans-Hex-2-enoyl-CoA
is: SBO:0000247
is: HMDB06870
boundary condition: false
is: http://identifiers.org/pubchem.compound/11966188
constant: false

metaR FACOAL180i
product: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (22305.2) or (2181.2) or (51703.1) or (2181.1) or (2180.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
type: Reaction
name: C180 fatty acid activation
reversible: false
is described by: ECO:0000269
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_80db8644_fa95_4486_bafe_09fb41ad00d4
boundary condition: true
is encoded by: hsa:11181
constant: false
name: TREH
has only substance units: false
is: SBO:0000252
initial amount: NaN
is: O43280
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_34ee6e8d_4a38_4081_a6f3_84ff5dba86be
boundary condition: true
is encoded by: hsa:79751
is: Q9H936
is: SBO:0000252
initial amount: NaN
type: Species
name: SLC25A22
has only substance units: false
constant: false
initial concentration: NaN

metaR r2124
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000185
reversible: true
product: MODEL1310110001#

metaR HESTRATRIOLte
kinetic law: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
product: MODEL1310110001#
name: hydroxylated estrogen derivative transport
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be exported NJ

http://identifiers.org/biomodels.db/MODEL1310110001#_b98dce2a_d2cd_447a_9685_355a9e40d80c
boundary condition: true
has only substance units: false
initial amount: NaN
name: NME1:NME2
is encoded by: hsa:4830
initial concentration: NaN
type: Species
constant: false
is: SBO:0000297

metaM cgly e
initial concentration: 1.0
notes: FORMULA: C5H10N2O3S CHARGE: 0 INCHI: InChI=1S/C5H10N2O3S/c6-3(2-11)5(10)7-1-4(8)9/h3,11H,1-2,6H2,(H,7,10)(H,8,9)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00784 EHMN_ABBREVIATION: C01419
type: Species
is: CHEBI:4047
boundary condition: false
name: L-cysteinylglycine
initial amount: NaN
has only substance units: false
is: HMDB00078
constant: false
is: SBO:0000247

metaM HC02204 c
is: SBO:0000247
has only substance units: false
name: prostaglandin-b1
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
is: CHEBI:27624
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
type: Species

metaM tetdece1crn c
initial amount: NaN
constant: false
notes: FORMULA: C21H39NO4 CHARGE: 0
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
is: HMDB02014
boundary condition: false
name: tetradecenoyl carnitine

metaR ACACT1r
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.9
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Tryptophan metabolism EC Number: 2.3.1.9 Confidence Level: 0 AUTHORS: NOTES:JLR- reversible form of ACACT1
fast: false
name: acetyl-CoA C-acetyltransferase
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110001#

metaM 3mgcoa m
is: CHEBI:57346
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C27H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C27H42N7O19P3S/c1-14(8-17(36)37)9-18(38)57-7-6-29-16(35)4-5-30-25(41)22(40)27(2,3)11-50-56(47,48)53-55(45,46)49-10-15-21(52-54(42,43)44)20(39)26(51-15)34-13-33-19-23(28)31-12-32-24(19)34/h8,12-13,15,20-22,26,39-40H,4-7,9-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,45,46)(H,47,48)(H2,28,31,32)(H2,42,43,44)/p-5/b14-8+/t15-,20-,21-,22+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01081 EHMN_ABBREVIATION: C03231
is: HMDB01057
name: trans-3-methylglutaconyl-CoA(5-)
boundary condition: false
is: SBO:0000247
has only substance units: false

metaR r2123
kinetic law: MODEL1310110001#
reversible: true
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110001#
product: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_c63cfaec_3543_40a9_ae1c_290af7fcaa37
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is: P20132
name: SDS
type: Species
initial concentration: NaN
is encoded by: hsa:10993
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_e3abbded_b031_4245_b12c_a386d1ca0eba
has only substance units: false
is encoded by: hsa:23428
is: Q9UHI5
name: SLC7A8
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_51f81cfc_1436_467e_8680_4946daf46b35
has only substance units: false
name: SLC7A8:SLC3A2
initial concentration: NaN
initial amount: NaN
is: SBO:0000297
is encoded by: hsa:23428
type: Species
boundary condition: true
has part: Q9UHI5
constant: false

metaM dhdascb e
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
name: dehydroascorbide(1-)
boundary condition: false
is: HMDB01264
is: CHEBI:58070
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_ca8e971e_2e37_45e5_9466_0be5ae535828
has only substance units: false
constant: false
is: SBO:0000252
name: HADH
initial concentration: NaN
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:3033
is: Q16836

http://identifiers.org/biomodels.db/MODEL1310110001#_868d5906_c447_400a_82af_f45bebf308f3
type: Species
is: SBO:0000252
constant: false
is: P49247
boundary condition: true
is encoded by: hsa:22934
name: RPIA
has only substance units: false
initial amount: NaN
initial concentration: NaN

metaM ksi pre13 g
is: CHEBI:58053
is: C00130
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C143H231N10O111S3X CHARGE: -4
name: keratan sulfate I biosynthesis, precursor 13
type: Species
is: HMDB00175

metaM 3hdececrn e
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C23H43NO5 CHARGE: 0
boundary condition: false
is: SBO:0000247
is: HMDB12930
has only substance units: false
initial amount: NaN
name: 3-hydroxyhexadecenoylcarnitine

metaM cmpacna g
is: HMDB01176
has only substance units: false
constant: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57812
type: Species
name: CMP-N-acetyl-beta-neuraminate(2-)

metaM 3aib m
type: Species
initial amount: NaN
has only substance units: false
is: HMDB02166
initial concentration: 1.0
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
is: CHEBI:33094
is: SBO:0000247
constant: false
name: (S)-3-aminoisobutyric acid
boundary condition: false

metaR r2122
kinetic law: MODEL1310110001#
type: Reaction
reversible: true
product: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110001#
is: SBO:0000185
modifier: MODEL1310110001#
fast: false

metaR PIK3
modifier: MODEL1310110001#
fast: false
product: MODEL1310110001#
name: phosphatidylinositol 3-kinase
kinetic law: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.11.1
is version of: http://identifiers.org/ec-code/2.7.1.154
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.137 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7628435,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.153
is version of: http://identifiers.org/ec-code/2.7.1.137

http://identifiers.org/biomodels.db/MODEL1310110001#_949f03f6_ef73_42a7_9323_7080c5872a20
name: GSR
constant: false
boundary condition: true
type: Species
is encoded by: hsa:2936
initial amount: NaN
is: P00390
has only substance units: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_fa52695e_13ce_471f_ad64_8774168db318
type: Species
is encoded by: hsa:10476
constant: false
is: SBO:0000297
boundary condition: true
has only substance units: false
has part: P24539
initial concentration: NaN
is encoded by: hsa:515
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:518
initial amount: NaN
has part: P18859
has part: O75947
is encoded by: hsa:522

http://identifiers.org/biomodels.db/MODEL1310110001#_9a48d57d_ba65_4f5c_88cb_22514b5fd410
is: O00754
initial concentration: NaN
has only substance units: false
boundary condition: true
type: Species
is encoded by: hsa:4125
initial amount: NaN
is: SBO:0000252
name: MAN2B1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_24ea7792_864b_4ef8_8222_719cac09a282
initial amount: NaN
type: Species
is encoded by: hsa:51227
name: PIGP
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN

metaR GAMYe
is: SBO:0000176
reactant: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.20
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.3 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:NCD
modifier: MODEL1310110001#
fast: false
name: glucoamylase, extracellular (glygn5 -> malt)

http://identifiers.org/biomodels.db/MODEL1310110001#_18c4ebd7_e298_4fae_a52c_36f0ff6bb0a5
has only substance units: false
constant: false
type: Species
is encoded by: hsa:125
is: SBO:0000297
boundary condition: true
initial amount: NaN
is encoded by: hsa:124
name: ADH1A:ADH1B
has part: P07327
has part: P00325
initial concentration: NaN

metaR GPDDA1
type: Reaction
product: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.46 Confidence Level: 0 AUTHORS: NOTES:JLR
reversible: false
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#

metaM 4abutn m
name: 4-ammoniobutanal
is: CHEBI:58264
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB01080
boundary condition: false
type: Species
has only substance units: false
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555

metaR EX adn LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Adenosine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_608d9037_84d0_40d0_8355_9986bfac245e
is: GO:0005737
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: cytoplasm
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110001#_44445658_fd84_4fd9_9ee8_284514f83512
constant: false
name: AGXT2L1
is encoded by: hsa:64850
has only substance units: false
is: Q8TBG4
boundary condition: true
initial amount: NaN
type: Species
is: SBO:0000252
initial concentration: NaN

metaR PYDXDH
is version of: http://identifiers.org/ec-code/1.2.3.1
is described by: ECO:0000269
product: MODEL1310110001#
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.2.3.1 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:IT
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
name: pyridoxal dehydrogenase
is: SBO:0000176
reactant: MODEL1310110001#

metaR r0055
name: 2-Oxopropanal:NADP+ oxidoreductase Pyruvate metabolism EC:1.2.1.49
reversible: true
kinetic law: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (353.1) or (3251.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.49 Confidence Level: 0 AUTHORS: PMID:20958,PMID:4383524,PMID:4391087,PMID:6014,PMID:7107625,PMID:7107626,PMID:7144586,PMID:7763257,PMID:7993370 NOTES:IT added 2 protons (are there really 2 protons produced?)
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.2.8
is: SBO:0000176
is described by: ECO:0000000
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.2.7
fast: false
reactant: MODEL1310110001#

metaR RE2666C
fast: false
product: MODEL1310110001#
name: RE2666
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycosphingolipid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7930586 NOTES:
is described by: ECO:0000000
reversible: false
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#

metaR ARACHDCOAtx
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reversible: true
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
is: SBO:0000185
name: fatty acid intracellular transport
is described by: ECO:0000000
fast: false

metaM HC02204 e
is: CHEBI:27624
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12,14,17,21H,2-11,13,15H2,1H3,(H,23,24)/b14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C00959
initial amount: NaN
is: SBO:0000247
constant: false
boundary condition: false
name: prostaglandin-b1
has only substance units: false
type: Species
initial concentration: 1.0

metaR BTNPLm
type: Reaction
name: holocarboxylase synthestase (biotin protein ligase), mitochondrial
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
modifier: MODEL1310110001#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.4.10
kinetic law: MODEL1310110001#
reversible: false
is: SBO:0000176
product: MODEL1310110001#

metaR SADT
kinetic law: MODEL1310110001#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110001#
product: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
name: sulfate adenylyltransferase
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.7.4 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.1.25
reversible: false

metaM fdp c
is: CHEBI:16905
is: SBO:0000247
is: HMDB01058
is: C00354
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00300 EHMN_ABBREVIATION: C00354
initial concentration: 1.0
name: D-Fructose 1,6-bisphosphate
initial amount: NaN
type: Species
constant: false
is: http://identifiers.org/pubchem.compound/3647
boundary condition: false
has only substance units: false

metaR HOXG
modifier: MODEL1310110001#
name: Heme oxygenase 1
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (3162.1) or (3163.1) SUBSYSTEM: Heme degradation EC Number: 1.14.99.3 Confidence Level: 0 AUTHORS: PMID:16356137 NOTES:TDV (4/28/2004) There are conflicting data on how many moles of NADPH consumed per mole of Biliverdine (Tenhunen 1969, Ryter, 2000). Heme oxygenase is a well known enzyme
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.14.99.3
is described by: ECO:0000134
reversible: false
product: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176

metaR AACTOOR
modifier: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
type: Reaction
reversible: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (8639.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:10328770,PMID:12878330 NOTES:
is described by: ECO:0000269
fast: false
name: Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)
is version of: http://identifiers.org/ec-code/1.4.3.21

metaM dhdascb c
type: Species
notes: FORMULA: C6H6O6 CHARGE: 0 INCHI: InChI=1S/C6H5O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,7-8H,1H2/q-1 EHMN_ABBREVIATION: C00425
has only substance units: false
initial amount: NaN
is: HMDB01264
is: SBO:0000247
name: dehydroascorbide(1-)
is: CHEBI:58070
boundary condition: false
initial concentration: 1.0
constant: false

metaR NACHEX27ly
is described by: ECO:0000269
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12562784 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
type: Reaction
fast: false

metaR MCLOR
reversible: true
reactant: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:7054184 NOTES:
name: 3-Mercaptolactate:NAD+ oxidoreductase
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
is: SBO:0000176
kinetic law: MODEL1310110001#

metaR FAOXC102m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)m
type: Reaction

metaR TDCRNe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of myristoyl carnitine into extra cellular space
type: Reaction

metaM ksi pre4 g
initial amount: NaN
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 4
is: C00130
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00175
notes: FORMULA: C101H165N7O72X CHARGE: -1
has only substance units: false
initial concentration: 1.0
constant: false

metaM zym int2 r
initial concentration: 1.0
constant: false
is: CHEBI:52386
is: SBO:0000247
name: zymosterol intermediate 2
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-20,23-24H,6,8-17H2,1-5H3/t19-,20+,23-,24+,26+,27-/m1/s1
initial amount: NaN

metaR ADNt
is described by: ECO:0000269
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:IT
type: Reaction
modifier: MODEL1310110001#
name: adenosine facilated transport in cytosol
reversible: true
kinetic law: MODEL1310110001#
fast: false
is: SBO:0000185
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_b095c4ef_7c89_4137_b38d_b9f4462a306f
initial amount: NaN
boundary condition: true
has only substance units: false
name: SOD2
is encoded by: hsa:6648
is: P04179
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

metaR r0317
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.4.4.2
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.4
reactant: MODEL1310110001#
name: citrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.4
is: SBO:0000176
product: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (AI761708.1) or (275.1) or (1738.1) or (2731.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.4 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.1.2.10

metaR r2129
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110001#
modifier: MODEL1310110001#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaM gmp g
constant: false
name: GMP(3-)
type: Species
initial amount: NaN
is: HMDB01397
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
boundary condition: false
has only substance units: false
is: CHEBI:58115

metaR EX nac LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Nicotinate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_bf3a3a22_1aec_48a8_8538_9ca7eaac3b77
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P11310
is encoded by: hsa:34
name: ACADM
has only substance units: false
type: Species
is: SBO:0000252
constant: false

metaR CSBPASEly
is described by: ECO:0000000
fast: false
product: MODEL1310110001#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
type: Reaction
name: chondroitin sulfate B proteoglycan protease, lysosome (endosome)
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#

metaR NACHEX26ly
modifier: MODEL1310110001#
product: MODEL1310110001#
reversible: false
reactant: MODEL1310110001#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
type: Reaction
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
kinetic law: MODEL1310110001#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_c774c6a6_8201_4d3b_af53_66d5a52881ca
has only substance units: false
initial concentration: NaN
constant: false
name: VNN3
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:55350
initial amount: NaN

metaM 3hdececrn c
initial concentration: 1.0
notes: FORMULA: C23H43NO5 CHARGE: 0
boundary condition: false
is: HMDB02014
constant: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
name: 3-hydroxyhexadecenoylcarnitine

metaM hs deg14 l
name: heparan sulfate, degradation product 14
is: SBO:0000247
is: CHEBI:16126
notes: FORMULA: C57H84N3O62S5 CHARGE: -7
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: false

metaM nadph m
is: C00005
has only substance units: false
boundary condition: false
is: HMDB00221
name: Nicotinamide adenine dinucleotide phosphate - reduced
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
is: CHEBI:57783
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247

metaM aacoa c
name: Acetoacetyl-CoA
is: SBO:0000247
is: C00332
is: CHEBI:57286
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
is: HMDB01484
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false

metaR GTHRDt
name: Glutathione transport into mitochondria
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutathione metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (8-15-2003) Meister, A, Mitochondrial changes associated with glutathione deficiency, Biochimica et Biophysica Acta 1271 (1995) 35-42. The article reports that this is an active transport but doesn't not specify if it uses atp.
fast: false
type: Reaction
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_c607e08a_28f7_4ce4_8911_e5dbe68d783a
initial concentration: NaN
name: SCD5
constant: false
is: Q86SK9
boundary condition: true
is encoded by: hsa:79966
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_504afbb8_9bf9_405d_8e21_e0e2cc62f123
constant: false
has part: P48728
has part: P23434
is encoded by: hsa:2653
is: SBO:0000297
is encoded by: hsa:2731
initial amount: NaN
boundary condition: true
initial concentration: NaN
has part: P23378
has only substance units: false
name: DLD:GCSH:GLDC:AMT
is encoded by: hsa:275
type: Species

metaR DESAT24 1
is: SBO:0000176
name: fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110001#
is described by: ECO:0000269
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (9415.1) SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.99.25 Confidence Level: 4 AUTHORS: NOTES:for homo sapiens, noted to actually be NADH-cyt b5, using NADH at present NJ
product: MODEL1310110001#
reactant: MODEL1310110001#

metaR r2128
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110001#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

metaR EX cspg a LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan exchange
type: Reaction

metaR GTHPm
reversible: true
modifier: MODEL1310110001#
name: glutathione peroxidase, mitochondria
is: SBO:0000176
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.11.1.12
kinetic law: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (10935.1) or (10935.2) or (2879.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:12427732 NOTES:TV (8-15-2003)
is version of: http://identifiers.org/ec-code/1.11.1.15
product: MODEL1310110001#
is described by: ECO:0000269
type: Reaction

metaR GLCter
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
name: glucose transport, endoplasmic reticulum
type: Reaction
fast: false
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:11879177 NOTES:NCD

metaR PPPGOm
type: Reaction
product: MODEL1310110001#
modifier: MODEL1310110001#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.3.3.4
notes: GENE_ASSOCIATION: (5498.1) SUBSYSTEM: Heme synthesis EC Number: 1.3.3.4 Confidence Level: 2 AUTHORS: PMID:8771201 NOTES:NCD
name: protoporphyrinogen oxidase, mitochondrial
kinetic law: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000304
reactant: MODEL1310110001#

metaR PNTK
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000176
name: pantothenate kinase
is version of: http://identifiers.org/ec-code/2.7.1.33
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (79646.1) or (80025.2) or (53354.1) or (53354.3) or (80025.1) or (53354.2) or (80025.3) or (80025.4) or (55229.1) SUBSYSTEM: CoA synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110001#
modifier: MODEL1310110001#
reversible: false
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_286c4a82_a5e6_429d_b66f_ebc51cd07f37
is encoded by: hsa:23632
type: Species
is: A8K3J4
name: CA14
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaM strdnccrn m
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
is: HMDB06463
initial amount: NaN
type: Species
notes: FORMULA: C25H41NO4 CHARGE: 0 INCHI: InChI=1/C25H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h6-7,9-10,13-14,17-18,23H,5,8,11-12,15-16,19-22H2,1-4H3/b7-6-,10-9-,14-13-,18-17-
name: stearidonyl carnitine
boundary condition: false

metaR C6CRNtcx
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexanoylcarnitine into cytosol
type: Reaction

metaM pmtcrn c
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: L-palmitoylcarnitine
is: CHEBI:17490
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB00222

metaR LYSOXp
type: Reaction
product: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000176
name: L-lysine oxidase, peroxisomal
reactant: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.4.3.14 Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957,PMID:6811962 NOTES:MM
reversible: false

metaR EX 5htrp LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-Hydroxy-L-tryptophan exchange
type: Reaction

metaR r2127
is: SBO:0000185
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110001#
fast: false
product: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
type: Reaction

metaM n2m2nmasn l
is: C04946
constant: false
boundary condition: false
has only substance units: false
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C58H96N5O40X CHARGE: 0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_afca4134_00dd_492b_9aac_a6bf555e7b04
is: SBO:0000252
is encoded by: hsa:114
boundary condition: true
type: Species
initial amount: NaN
is: Q4F7X0
name: ADCY8
has only substance units: false
initial concentration: NaN
constant: false

metaR r2126
reversible: true
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110001#
reactant: MODEL1310110001#

metaM gmp e
name: GMP(3-)
constant: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
type: Species
initial concentration: 1.0
initial amount: NaN
is: HMDB01397
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:58115

http://identifiers.org/biomodels.db/MODEL1310110001#_87341aa1_86c0_4bfc_a36a_60d2c165c74b
has only substance units: false
is: P08842
boundary condition: true
is: SBO:0000252
is encoded by: hsa:412
name: STS
constant: false
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_d80a5497_4276_4d31_8082_3d9e87bbdff1
type: Species
name: ADCY7
has only substance units: false
initial concentration: NaN
is encoded by: hsa:113
is: SBO:0000252
initial amount: NaN
is: P51828
constant: false
boundary condition: true

metaM grdp x
is: SBO:0000247
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:58057
boundary condition: false
name: geranyl diphosphate(3-)
notes: FORMULA: C10H17O7P2 CHARGE: -3 INCHI: InChI=1S/C10H20O7P2/c1-9(2)5-4-6-10(3)7-8-16-19(14,15)17-18(11,12)13/h5,7H,4,6,8H2,1-3H3,(H,14,15)(H2,11,12,13)/p-3/b10-7+ HEPATONET_1.0_ABBREVIATION: HC00288 EHMN_ABBREVIATION: C00341
type: Species
constant: false
is: HMDB01285

http://identifiers.org/biomodels.db/MODEL1310110001#_b536d680_408b_4743_81b1_d189b1e6a9b5
is: P07195
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: LDHB
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3945

metaM b2coa m
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-4-5-16(34)53-9-8-27-15(33)6-7-28-23(37)20(36)25(2,3)11-46-52(43,44)49-51(41,42)45-10-14-19(48-50(38,39)40)18(35)24(47-14)32-13-31-17-21(26)29-12-30-22(17)32/h4-5,12-14,18-20,24,35-36H,6-11H2,1-3H3,(H,27,33)(H,28,37)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/b5-4+/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00572 EHMN_ABBREVIATION: C00877
initial amount: NaN
is: HMDB02009
is: CHEBI:57332
boundary condition: false
has only substance units: false
name: crotonoyl-CoA(4-)
is: SBO:0000247

metaR RE1534M
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
product: MODEL1310110001#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000000
kinetic law: MODEL1310110001#
name: RE1534

metaR CMPACNAtg
fast: false
product: MODEL1310110001#
is described by: ECO:0000269
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
name: CMP-Sia Golgi transport via CMP antiport
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (10559.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12759756,PMID:9010752,PMID:9644260 NOTES:NCD
type: Reaction
reversible: true
is: SBO:0000185

metaR EX Tyr ggn LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Tyr-194 of apo-glycogenin protein (primer for glycogen synthesis) exchange
type: Reaction

metaM decdp m
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
has only substance units: false
initial amount: NaN
name: all trans Decaprenyl diphosphate
constant: false
is: HMDB06288
is: SBO:0000247
type: Species
initial concentration: 1.0
boundary condition: false

metaR HDECAACBP
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxyhexadecanoylcoa from mitochondria into the cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_bf6827a3_dce7_4d6a_aa0b_603879834120
is encoded by: hsa:79071
is: Q9H5J4
name: ELOVL6
has only substance units: false
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN

metaM 5hoxindoa c
initial amount: NaN
is: CHEBI:27823
is: SBO:0000247
constant: false
is: HMDB00763
type: Species
notes: FORMULA: C10H8NO3 CHARGE: -1 INCHI: InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14) HEPATONET_1.0_ABBREVIATION: HC01537 EHMN_ABBREVIATION: C05635
has only substance units: false
boundary condition: false
name: 5-Hydroxyindoleacetate
initial concentration: 1.0

metaR sink pre prot LPAREN r RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: 2.4.99.9 Confidence Level: 1 AUTHORS: PMID:9822625 NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycophosphatidylinositol (GPI)-anchored protein precursor sink
type: Reaction

metaR r0426
type: Reaction
modifier: MODEL1310110001#
name: isocitrate hydro-lyase Citrate cycle (TCA cycle) / Glyoxylate and dicarboxylate metabolism EC:4.2.1.3
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5860.1) SUBSYSTEM: Unassigned EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:15263083,PMID:16511074 NOTES:
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.5.1.34

metaR NCKt
name: Na+/Ca2+-K+ exchange
is: SBO:0000185
product: MODEL1310110001#
reversible: true
fast: false
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (123041.2) or (57419.1) or (9187.1) or (123041.3) or (25769.1) or (123041.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
reactant: MODEL1310110001#

metaR PPCOAOm
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (80724.1) or (27034.1) or (36.1) or (35.1) or (84129.1) or (34.1) or (28976.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:12359132,PMID:12359260,PMID:15560374,PMID:2565344,PMID:3035565,PMID:7698750,PMID:8276399 NOTES:NCD
modifier: MODEL1310110001#
is described by: ECO:0000269
product: MODEL1310110001#
name: Propanoyl-CoA:FAD 2,3-oxidoreductase, mitochondrial

metaM pydx5p e
is: CHEBI:597326
name: pyridoxal 5'-phosphate(2-)
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C8H8NO6P CHARGE: -2 INCHI: InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018
is: HMDB01491
type: Species
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false

metaR CHOLESACATc
reactant: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.26
type: Reaction
modifier: MODEL1310110001#
fast: false
is described by: ECO:0000134
is: SBO:0000176
name: esterification of cholesterol to cholesterol ester within enterocytes
notes: GENE_ASSOCIATION: (8435.1) or (6646.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 2 AUTHORS: Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 143-144. charasuraisin, c. in short dissertation 19 (2008) NOTES:re-formation of cholesterol ester within enterocytes, then exit in chylomicrons into the lymph.
reversible: false

metaR EX ksi LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: keratan sulfate I exchange
type: Reaction

metaM 3tetd7ecoa c
name: 3-hydroxy tetradecenoyl-7-coa
initial amount: NaN
is: HMDB05066
is: SBO:0000247
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
boundary condition: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4

http://identifiers.org/biomodels.db/MODEL1310110001#_73f99731_d92f_4b28_bf27_af21bb35bfa4
boundary condition: true
initial amount: NaN
is encoded by: hsa:3633
name: INPP5B
has only substance units: false
type: Species
is: P32019
is: SBO:0000252
initial concentration: NaN
constant: false

metaR HSD11B2r
reversible: true
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.146
notes: GENE_ASSOCIATION: (3291.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
kinetic law: MODEL1310110001#
name: 11-beta-hydroxysteroid dehydrogenase type 2
type: Reaction
is: SBO:0000176
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000269
fast: false

metaM xyl D e
boundary condition: false
type: Species
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
is: CHEBI:15936
is: SBO:0000247
name: aldehydo-D-xylose
initial concentration: 1.0

metaR FAOXTC142TC122m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C14:2-->C12:2)m
type: Reaction

metaM leuleu e
name: Leucylleucine
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/94244
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H24N2O3 CHARGE: 0
is: SBO:0000247
has only substance units: false

metaM xol7ah c
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:2290
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h17-19,21-25,29H,6-16H2,1-5H3/t18-,19+,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01460 EHMN_ABBREVIATION: C05451
is: SBO:0000247
has only substance units: false
name: 7alpha-hydroxy-5beta-cholestan-3-one
is: HMDB06892

metaR r1652
reactant: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is: SBO:0000185

metaM lneldccoa m
is: http://identifiers.org/pubchem.compound/5462164
initial amount: NaN
type: Species
is: HMDB01064
name: linoelaidyl coenzyme A
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
boundary condition: false

metaR ACCOAgt
product: MODEL1310110001#
name: acetyl-coa transport
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12739170 NOTES:transport between cytosol and Golgi/ER presumed presumed facilitated transport, but unknown co-substrates, see PMID: 12739170, Hirabayashi et al NJ
kinetic law: MODEL1310110001#
is: SBO:0000185
reversible: true
fast: false
type: Reaction
is described by: ECO:0000269
reactant: MODEL1310110001#
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_a41a37fc_af27_44fe_8119_fc17a644876b
type: Species
initial concentration: NaN
name: HNMT
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is: P50135
is encoded by: hsa:3176

metaR EX 4hpro LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for hydroxy proline
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_b5d562eb_83fb_4d4a_a890_83fa8d65c739
constant: false
has only substance units: false
is: SBO:0000252
name: SLC25A1
is encoded by: hsa:6576
initial amount: NaN
initial concentration: NaN
is: D9HTE9
type: Species
boundary condition: true

metaR C141ACBP
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradecenoyl coa from mitochondria into cytosol
type: Reaction

metaR PDE4n
is version of: http://identifiers.org/ec-code/3.1.4.35
reactant: MODEL1310110001#
name: 3',5'-cyclic-nucleotide phosphodiesterase, Nucleus
product: MODEL1310110001#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5152.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:12565835,PMID:14527714,PMID:9624146 NOTES:NCD. IT
modifier: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
reversible: false
fast: false
is: SBO:0000176

metaM sphmyln hs g
is: SBO:0000247
has only substance units: false
is: CHEBI:58216
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
initial amount: NaN
name: sphingomyelin betaine
type: Species
boundary condition: false
initial concentration: 1.0
constant: false

metaM 3aib c
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
constant: false
is: CHEBI:33094
is: HMDB02166
name: (S)-3-aminoisobutyric acid
has only substance units: false
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM 5HPET c
type: Species
is: CHEBI:57450
has only substance units: false
constant: false
name: 5(S)-HPETE(1-)
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
is: HMDB01193

http://identifiers.org/biomodels.db/MODEL1310110001#_392060ac_550f_4165_a84a_1af47980fb65
name: _W74642_1_c
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:W74642
type: Species
has only substance units: false

metaM 4abutn c
notes: FORMULA: C4H10NO CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
initial concentration: 1.0
name: 4-Aminobutanal
constant: false
is: CHEBI:58264
has only substance units: false
initial amount: NaN
is: HMDB01080
type: Species
is: SBO:0000247
is: C00555
boundary condition: false

metaM n2m2nmasn e
initial concentration: 1.0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
constant: false
initial amount: NaN
notes: FORMULA: C58H96N5O40X CHARGE: 0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: C04946
type: Species

metaM sbcoa c
initial concentration: 1.0
notes: FORMULA: C29H43N7O19P3S CHARGE: -5
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
is: C02838
name: suberylcoa
is: HMDB00791
type: Species

metaR FAOXC164C143x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)x
type: Reaction

metaR r1651
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
modifier: MODEL1310110001#

metaR PCm
type: Reaction
name: pyruvate carboxylase
reactant: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#
is described by: ECO:0000269
kinetic law: MODEL1310110001#
reversible: false
product: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/6.4.1.1
notes: GENE_ASSOCIATION: (5091.1) or (5091.2) SUBSYSTEM: Pyruvate metabolism EC Number: 6.4.1.1 Confidence Level: 4 AUTHORS: PMID:6548474 NOTES:TV Metabolism at a glance

http://identifiers.org/biomodels.db/MODEL1310110001#_dafabf8b_3155_45c7_912e_a8731f1f8e04
name: PCCA:PCCB
is encoded by: hsa:5096
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:5095
has part: P05166
is: SBO:0000297
initial concentration: NaN
has part: C9JPQ8

metaR r1654
fast: false
modifier: MODEL1310110001#
reversible: true
is described by: ECO:0000000
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
reactant: MODEL1310110001#

metaR PPItx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
name: Diphosphate transporter, peroxisome
reversible: true
is: SBO:0000185
product: MODEL1310110001#
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_04eaa0e0_f403_4427_8877_61c98d0d5b58
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: PRDX2
is encoded by: hsa:7001
has only substance units: false
type: Species

metaR MHISOR
is: SBO:0000176
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
reversible: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Histidine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:12072962,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000269
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.4.3.21
name: N-Methylhistamine:oxygen oxidoreductase (deaminating)

metaR DOLPGT1 Ler
kinetic law: MODEL1310110001#
fast: false
reversible: false
modifier: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
is described by: ECO:0000000
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.267
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (29929.1) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD

metaR BAMPPALDOX
is version of: http://identifiers.org/ec-code/1.2.1.36
is described by: ECO:0000212
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.36 Confidence Level: 1 AUTHORS: PMID:12586697 NOTES:SAB
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
reversible: false
product: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#

metaM pydx5p c
constant: false
is: CHEBI:597326
boundary condition: false
is: C00018
initial concentration: 1.0
is: HMDB01491
has only substance units: false
type: Species
name: Pyridoxal 5'-phosphate
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C8H8NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00028 EHMN_ABBREVIATION: C00018

metaM HC01115 c
constant: false
has only substance units: false
boundary condition: false
name: NeuNGc
is: CHEBI:29025
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C11H18NO10 CHARGE: -1 INCHI: InChI=1S/C11H19NO10/c13-2-5(16)8(18)9-7(12-6(17)3-14)4(15)1-11(21,22-9)10(19)20/h4-5,7-9,13-16,18,21H,1-3H2,(H,12,17)(H,19,20)/p-1/t4-,5+,7+,8+,9+,11?/m0/s1 EHMN_ABBREVIATION: C03410
initial amount: NaN
type: Species

metaR RE1523M
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110001#
name: RE1523
type: Reaction
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110001#
product: MODEL1310110001#

metaM T antigen g
name: T antigen (core 1)
constant: false
initial amount: NaN
notes: FORMULA: C14H24NO10X CHARGE: 0
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:22783

metaM cmpacna n
has only substance units: false
name: CMP-N-acetyl-beta-neuraminate(2-)
is: SBO:0000247
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB01176
is: CHEBI:57812
type: Species

metaM leuleu c
is: SBO:0000247
initial amount: NaN
type: Species
is: http://identifiers.org/pubchem.compound/94244
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C12H24N2O3 CHARGE: 0
constant: false
has only substance units: false
name: Leucylleucine

metaR TETPENT3t
is described by: ECO:0000000
kinetic law: MODEL1310110001#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reactant: MODEL1310110001#
product: MODEL1310110001#
name: fatty acid transport via diffusion
reversible: true

metaR EX 3thexddcoacrn
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans7,10-hexadecadienoyl carnitine
type: Reaction

metaR XYLUR
modifier: MODEL1310110001#
fast: false
reversible: true
type: Reaction
name: xylulose reductase
notes: GENE_ASSOCIATION: (51181.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.10 Confidence Level: 4 AUTHORS: PMID:11882650,PMID:6821187 NOTES:
product: MODEL1310110001#
is described by: ECO:0000269
kinetic law: MODEL1310110001#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.10
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_9e546c71_b4b0_4611_af57_7d735b1b72ab
boundary condition: true
constant: false
is: E9KL44
name: HADHA
type: Species
is encoded by: hsa:3030
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_4ffc6730_1bce_4ddd_a06f_842b9840a62f
type: Species
boundary condition: true
has part: Q07326
initial concentration: NaN
name: PIGF:PIGO
initial amount: NaN
has part: Q8TEQ8
is: SBO:0000297
has only substance units: false
constant: false
is encoded by: hsa:84720
is encoded by: hsa:5281

metaR FACOAL1822
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
product: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110001#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110001#

metaR GGH 7DHFe
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110001#
name: Gamma-glutamyl hydrolase (7DHF), extracellular
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is version of: http://identifiers.org/ec-code/3.4.19.9
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110001#

metaR PSt3
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.7.8.8 Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
product: MODEL1310110001#
name: phosphatidylserine transport
is: SBO:0000185
is described by: ECO:0000269
type: Reaction

metaR ICDHyrm
type: Reaction
notes: GENE_ASSOCIATION: (3418.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.42 Confidence Level: 4 AUTHORS: PMID:12234803,PMID:8187868 NOTES:The reaction may be reversible. Strathern shows the reaction as irreversible. IF
is: SBO:0000176
reactant: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
name: Isocitrate dehydrogenase (NADP+)
is version of: http://identifiers.org/ec-code/1.1.1.42
is described by: ECO:0000269
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true

metaM n2m2nmasn g
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
constant: false
notes: FORMULA: C58H96N5O40X CHARGE: 0
is: C04946
is: SBO:0000247
boundary condition: false

metaM nadph c
type: Species
boundary condition: false
is: CHEBI:57783
is: SBO:0000247
is: C00005
initial amount: NaN
is: HMDB00221
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
constant: false
name: Nicotinamide adenine dinucleotide phosphate - reduced
has only substance units: false
initial concentration: 1.0

metaR EX drib LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Deoxyribose exchange
type: Reaction

metaM 2dpmhobq m
notes: FORMULA: C58H88O4 CHARGE: 0 INCHI: InChI=1S/C58H88O4/c1-43(2)23-14-24-44(3)25-15-26-45(4)27-16-28-46(5)29-17-30-47(6)31-18-32-48(7)33-19-34-49(8)35-20-36-50(9)37-21-38-51(10)39-22-40-52(11)41-42-54-53(12)55(59)57(61)58(62-13)56(54)60/h23,25,27,29,31,33,35,37,39,41,61H,14-22,24,26,28,30,32,34,36,38,40,42H2,1-13H3/b44-25+,45-27+,46-29+,47-31+,48-33+,49-35+,50-37+,51-39+,52-41+
initial concentration: 1.0
type: Species
initial amount: NaN
name: 2-decaprenyl-5-hydroxy-6-methoxy-3-methyl-1,4-benzoquinone
is: HMDB06484
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:50771
boundary condition: false

metaM 3mlda c
has only substance units: false
type: Species
is: HMDB02820
is: C05828
constant: false
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
name: 3-Methylimidazoleacetic acid
is: http://identifiers.org/pubchem.compound/8122
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM 3aib e
is: HMDB02166
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1S/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1 EHMN_ABBREVIATION: C03284
name: (S)-3-aminoisobutyric acid
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false
is: CHEBI:33094

metaR r1653
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
modifier: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR COt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:TDV
reversible: true
reactant: MODEL1310110001#
is: SBO:0000185
name: CO transporter via diffusion
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110001#

metaM aacoa m
initial concentration: 1.0
type: Species
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
initial amount: NaN
is: HMDB01484
name: acetoacetyl-CoA(4-)
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:57286
has only substance units: false

metaM 4abutn e
is: HMDB01080
has only substance units: false
initial amount: NaN
initial concentration: 1.0
name: 4-ammoniobutanal
boundary condition: false
constant: false
is: CHEBI:58264
notes: FORMULA: C4H10NO CHARGE: 1 INCHI: InChI=1S/C4H9NO/c5-3-1-2-4-6/h4H,1-3,5H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00428 EHMN_ABBREVIATION: C00555
is: SBO:0000247
type: Species

metaR FACOAL1821
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE1514C
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
name: fatty-acid--CoA ligase
product: MODEL1310110001#
is: SBO:0000176
reversible: true
fast: false

metaM dcyt e
name: Deoxycytidine
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
is: HMDB00014
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
is: C00881
type: Species
initial concentration: 1.0
constant: false
is: CHEBI:15698

http://identifiers.org/biomodels.db/MODEL1310110001#_4cca3cc9_2800_42d5_a7b5_18f2f5b68533
is encoded by: hsa:170712
is: SBO:0000252
is: Q8TF08
initial amount: NaN
name: COX7B2
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species

metaM pentcoa m
notes: FORMULA: C26H40N7O17P3S CHARGE: -4
is: SBO:0000247
is: C00888
has only substance units: false
type: Species
is: HMDB13037
constant: false
name: pentanoylcoa
initial amount: NaN
initial concentration: 1.0
boundary condition: false

metaM pan4p e
initial amount: NaN
is: CHEBI:47942
initial concentration: 1.0
is: HMDB01416
name: Pantetheine 4'-phosphate
notes: FORMULA: C11H21N2O7PS CHARGE: -2
is: C01134
type: Species
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_f196486c_9cdc_4a2b_a876_84f2b25fa774
has only substance units: false
constant: false
type: Species
name: TK2
is: O00142
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:7084
boundary condition: true
initial amount: NaN

metaM 3sala c
is: CHEBI:61085
initial concentration: 1.0
has only substance units: false
name: 3-Sulfino-L-alanine
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: C00606
notes: FORMULA: C3H5NO4S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606

metaR FAOXOHC16C16DCc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid omega oxidation(w-OHC16-->C16DC)c
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_b3f4665c_51e4_4a5b_b4cf_0efd267b6678
boundary condition: true
initial concentration: NaN
is: Q02318
initial amount: NaN
is: SBO:0000252
name: CYP27A1
type: Species
has only substance units: false
is encoded by: hsa:1593
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_b6aba04c_00e7_42d3_8464_3a8e801a8ee5
name: GALT
is: SBO:0000252
boundary condition: true
is: E7ET32
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:2592
initial amount: NaN
constant: false

metaM 2docopencoa m
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
name: 2,7,10,13,16-docosapentenoylcoa
initial concentration: 1.0
constant: false
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_752b54e4_2f46_454d_8cb5_8ae112f63ff8
is encoded by: hsa:5158
name: PDE6A:PDE6H:PDE6B
boundary condition: true
initial concentration: NaN
has part: B7Z9T9
has part: P16499
type: Species
is encoded by: hsa:5149
initial amount: NaN
has only substance units: false
is encoded by: hsa:5145
constant: false
has part: Q13956
is: SBO:0000297

metaR FAOXC1811603m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
modifier: MODEL1310110001#
type: Reaction
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation fatty acid
reactant: MODEL1310110001#

metaR EX s2l2n2m2masn LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: de-Fuc form of PA6 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_b047d0ec_8b32_4fea_8759_cef02ca13cec
type: Species
is encoded by: hsa:56953
initial concentration: NaN
constant: false
is: Q9NPB1
boundary condition: true
initial amount: NaN
name: NT5M
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_987d42f2_2917_4d2e_b40a_69d16660fa7e
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9377
initial concentration: NaN
initial amount: NaN
name: COX5A
has only substance units: false
is: P20674
constant: false

metaM urcan c
notes: FORMULA: C6H5N2O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00534 EHMN_ABBREVIATION: C00785
type: Species
boundary condition: false
is: HMDB00301
is: CHEBI:17771
name: Urocanate
constant: false
is: C00785
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR FAOXC101C8m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8)m
type: Reaction

metaM pchol hs c
initial concentration: 1.0
name: Phosphatidylcholine
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
is: CHEBI:16110

http://identifiers.org/biomodels.db/MODEL1310110001#_854788fc_45d5_4d97_8b14_aa2d9f7ea094
initial concentration: NaN
is: SBO:0000252
name: NANS
constant: false
boundary condition: true
has only substance units: false
is: Q9NR45
is encoded by: hsa:54187
type: Species
initial amount: NaN

metaR LNLNCACRNt
fast: false
kinetic law: MODEL1310110001#
type: Reaction
reversible: false
product: MODEL1310110001#
is: SBO:0000185
name: transport into the mitochondria (carnitine)
modifier: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000269

metaM 3hpp m
is: CHEBI:16510
initial concentration: 1.0
is: HMDB00700
initial amount: NaN
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c4-2-1-3(5)6/h4H,1-2H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00625 EHMN_ABBREVIATION: C01013
has only substance units: false
constant: false
type: Species
name: 3-hydroxypropionate
boundary condition: false
is: SBO:0000247

metaR TSULt4 3
kinetic law: MODEL1310110001#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (6561.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10811962,PMID:11161786 NOTES:NCD
reactant: MODEL1310110001#
fast: false
is described by: ECO:0000269
modifier: MODEL1310110001#
product: MODEL1310110001#
reversible: true
name: thiosulfate transport via sodium symport

metaM h x
is: http://identifiers.org/pubchem.compound/3380
name: proton
has only substance units: false
is: C00080
initial amount: NaN
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:24636
type: Species

metaM 3mlda e
is: SBO:0000247
constant: false
boundary condition: false
is: HMDB02820
initial concentration: 1.0
is: C05828
has only substance units: false
notes: FORMULA: C6H7N2O2 CHARGE: -1 INCHI: InChI=1/C6H8N2O2/c1-8-3-5(7-4-8)2-6(9)10/h3-4H,2H2,1H3,(H,9,10) EHMN_ABBREVIATION: C05828
is: http://identifiers.org/pubchem.compound/8122
initial amount: NaN
name: 3-Methylimidazoleacetic acid
type: Species

metaM dolmanp L r
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial concentration: 1.0
is: SBO:0000247
name: Dolichyl phosphate D-mannose, human liver homolog
constant: false
is: CHEBI:15809
boundary condition: false

metaR CMPACNAtn
is: SBO:0000185
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110001#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000000
name: CMP-Sia nuclear export
kinetic law: MODEL1310110001#

metaR FAOXC102C81m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C8:1)m
type: Reaction

metaR NACHEX11ly
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
is: SBO:0000176
kinetic law: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
name: beta-N-acetylhexosaminidase, lysosomal
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_8b4bd867_749f_489f_a87f_2db891962f2a
initial concentration: NaN
is: SBO:0000252
constant: false
type: Species
is encoded by: hsa:55350
has only substance units: false
initial amount: NaN
boundary condition: true
name: VNN3

metaR GluForTx
reactant: MODEL1310110001#
name: Glutamate formimidoyltransferase
type: Reaction
reversible: false
is described by: ECO:0000269
fast: false
product: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (10841.1) or (10841.2) SUBSYSTEM: Histidine metabolism EC Number: 2.1.2.5 Confidence Level: 4 AUTHORS: PMID:12815595 NOTES:SAB
is version of: http://identifiers.org/ec-code/2.1.2.5
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_a53cfefa_9954_4b98_8d6e_7913121f276f
initial concentration: NaN
type: Species
constant: false
is: Q308M7
boundary condition: true
initial amount: NaN
is encoded by: hsa:5169
has only substance units: false
is: SBO:0000252
name: ENPP3

metaR H2Otly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110001#
is: SBO:0000185
name: H2O transport, lysosomal
product: MODEL1310110001#
fast: false

metaM pan4p c
name: Pantetheine 4'-phosphate
initial concentration: 1.0
is: CHEBI:47942
is: C01134
has only substance units: false
initial amount: NaN
type: Species
is: HMDB01416
boundary condition: false
constant: false
notes: FORMULA: C11H21N2O7PS CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
is: SBO:0000247

metaM sphmyln hs c
is: SBO:0000247
is: CHEBI:58216
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C23H48N2O5PFULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02007
type: Species
has only substance units: false
name: sphingomyelin betaine

http://identifiers.org/biomodels.db/MODEL1310110001#_cd298da7_74f4_47a6_b033_3500e20163d9
name: ENPP1
is encoded by: hsa:5167
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: P22413
type: Species
has only substance units: false
constant: false

metaR r0424
is version of: http://identifiers.org/ec-code/1.17.1.4
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176
reversible: true
modifier: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (7498.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
product: MODEL1310110001#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
type: Reaction

metaR PI345P5P
is: SBO:0000176
kinetic law: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.36
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3633.1) or (27124.1) or (3635.1) or (3636.1) or (8871.1) or (56623.1) or (8867.2) or (27124.2) or (8867.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10358929 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
name: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
reactant: MODEL1310110001#
fast: false

metaR r1650
reactant: MODEL1310110001#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
product: MODEL1310110001#

metaM xyl D c
has only substance units: false
initial amount: NaN
type: Species
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: aldehydo-D-xylose
is: CHEBI:15936

metaR RE3000M
type: Reaction
notes: GENE_ASSOCIATION: (1891.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
name: RE3000
modifier: MODEL1310110001#
reversible: true
product: MODEL1310110001#
fast: false
is: SBO:0000176
is described by: ECO:0000000

metaR PROSTGF2t
is described by: ECO:0000269
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: prostaglandin uniport
reactant: MODEL1310110001#
type: Reaction
reversible: true
modifier: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (6582.2) or (6582.1) or (6580.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:electrogenic, Na indepdendent & rev NJ
is: SBO:0000185

metaR G14T12g
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
reversible: false
fast: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.38
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaM gmp n
is: CHEBI:58115
initial concentration: 1.0
is: HMDB01397
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C10H12N5O8P CHARGE: -2 INCHI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/p-2/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
has only substance units: false
boundary condition: false
name: GMP(3-)
is: SBO:0000247

metaR BTNt2
fast: false
type: Reaction
product: MODEL1310110001#
reversible: true
name: Biotin reversible transport via proton symport
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9508842,PMID:9649795,PMID:9824713 NOTES:NCD
kinetic law: MODEL1310110001#
is: SBO:0000185

metaR FAOXC102x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:2)x
type: Reaction

metaR NAt
is: SBO:0000185
name: sodium transport (uniport)
notes: GENE_ASSOCIATION: (6526.1) or (6523.1) or (6528.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10893432,PMID:11024018,PMID:11034615,PMID:12679487,PMID:12748858,PMID:1372904,PMID:15546855,PMID:2490366,PMID:7537337,PMID:7789985,PMID:8063771,PMID:8559252,PMID:8806637,PMID:9341168 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
product: MODEL1310110001#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_dd127bff_82e1_4923_86e5_9167d652ac1e
is: SBO:0000252
has only substance units: false
constant: false
is encoded by: hsa:206358
boundary condition: true
type: Species
initial amount: NaN
name: SLC36A1
is: Q1LZ56
initial concentration: NaN

metaR GALSIDEtl
reversible: true
name: galactocerebroside intracellular transport
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
is described by: ECO:0000000
product: MODEL1310110001#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110001#

metaR r0423
fast: false
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.42 Confidence Level: 0 AUTHORS: PMID:10521434,PMID:16489927,PMID:9866202 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110001#
name: Isocitrate:NADP+ oxidoreductase (decarboxylating) Citrate cycle (TCA cycle) EC:1.1.1.42
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#

metaR LNLCCRNt
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
reactant: MODEL1310110001#
is: SBO:0000185
reversible: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000269
modifier: MODEL1310110001#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_e452e9c8_ce2c_4fae_a56f_d353e06b2381
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AV727634
constant: false
initial concentration: NaN
boundary condition: true
type: Species
name: _AV727634_1_c
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_d62825c3_f3ee_42c2_9477_99c83997d39c
has only substance units: false
initial amount: NaN
name: GBA
is encoded by: hsa:2629
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
is: B7Z6S1

metaM xol7ah3 c
boundary condition: false
is: CHEBI:28540
is: HMDB12455
is: SBO:0000247
type: Species
constant: false
initial amount: NaN
name: 5beta-cholestane-3alpha,7alpha,26-triol
initial concentration: 1.0
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
has only substance units: false

metaM dolp U c
constant: false
initial amount: NaN
name: dolichyl phosphate(2-)
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: CHEBI:57683
initial concentration: 1.0

metaM pchol hs e
initial concentration: 1.0
name: Phosphatidylcholine
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:16110
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0
has only substance units: false
is: SBO:0000247
constant: false

metaR CLPNDCOAtx
reversible: true
name: fatty acid intracellular transport
kinetic law: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110001#_0da3d0bd_da99_462a_b089_ca2344069675
name: ACP6
is encoded by: hsa:51205
constant: false
type: Species
is: Q9NPH0
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
is: SBO:0000252

metaR FAOXC18480m
name: Beta oxidation of fatty acid
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 4 degrees loss of saturation -> only 1 fad oxidized to fadh2 peroxisomal (very long chain FA) c18:4,n-6 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176
product: MODEL1310110001#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_70419892_4c37_4c3e_8cd0_50f70e968d79
is: Q9UN76
initial amount: NaN
name: SLC6A14
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:11254
is: SBO:0000252

metaR FAOXC163C164Gm
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_993d3b34_a8d1_47f6_b8c1_9610bf703d79
name: GBA
constant: false
type: Species
is: B7Z5G2
initial amount: NaN
is encoded by: hsa:2629
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252

metaR r1433
reversible: false
kinetic law: MODEL1310110001#
type: Reaction
name: NADPH:oxidized-thioredoxin oxidoreductase Pyrimidine metabolism EC:1.8.1.9
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:5553404,PMID:5671058 NOTES:
fast: false
reactant: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#

metaR MALSO4tm
name: Malate:sulfate antiport, mitochondrial
product: MODEL1310110001#
is described by: ECO:0000269
modifier: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
is: SBO:0000185
fast: false

metaM HC00664 c
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:58695
type: Species
name: D-tagatofuranose 6-phosphate(2-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/p-2/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C01097

metaR r1659
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_fdb546ce_948e_489f_9c47_0907f841ca90
name: ACOX1
type: Species
initial amount: NaN
is: Q15067
is encoded by: hsa:51
is: SBO:0000252
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_5145f35a_fd09_4ee2_a334_c2bf13902f49
constant: false
boundary condition: true
has only substance units: false
type: Species
name: _AI694761_1_c
is: SBO:0000252
is encoded by: hsa:AI694761
initial amount: NaN
initial concentration: NaN

metaR RE0456M
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6997299,PMID:8483833 NOTES:
is described by: ECO:0000000
name: RE0456
type: Reaction

metaR PAIL45P HStn
product: MODEL1310110001#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
name: phosphatidylinositol 4,5-bisphosphate nuclear transport (diffusion)

metaM dhf m
name: dihydrofolate(2-)
constant: false
notes: FORMULA: C19H19N7O6 CHARGE: -2 INCHI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB01056
is: CHEBI:57451

metaM dolp U r
type: Species
name: dolichyl phosphate(2-)
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
notes: FORMULA: C1025H1670O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial concentration: 1.0
is: CHEBI:57683

metaR PCt
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: true
is: SBO:0000185
name: phosphatidylcholine transporter
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11826283,PMID:7912658 NOTES:for PC secretion into bile NJ
fast: false
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.44
kinetic law: MODEL1310110001#

metaR DM dgpi prot hs r
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM dgpi prot hs(r)
type: Reaction

metaR FAOXC183C163m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)m
type: Reaction

metaM nadph x
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide phosphate - reduced
boundary condition: false
constant: false
is: SBO:0000247
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
type: Species
is: C00005
is: HMDB00221
is: CHEBI:57783
initial amount: NaN
has only substance units: false

metaM gam6p c
constant: false
notes: FORMULA: C6H13NO8P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00298 EHMN_ABBREVIATION: C00352
is: HMDB01254
is: CHEBI:12962
name: D-Glucosamine 6-phosphate
is: SBO:0000247
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR EX HC01361 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Dihydroneopterin
type: Reaction

metaR RE3001M
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110001#
is: SBO:0000176
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (1666.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.34 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
name: RE3001
is version of: http://identifiers.org/ec-code/1.3.1.34

metaR r1434
is described by: ECO:0000000
kinetic law: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
name: Transport reaction
reversible: false
reactant: MODEL1310110001#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_020cb3c1_a969_4f84_9ae6_c21d304c8a8a
initial amount: NaN
name: ENTPD1
is: Q86VV3
constant: false
has only substance units: false
is encoded by: hsa:953
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species

metaR COQ7m
modifier: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (10229.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.14.13.- IT
is: SBO:0000176
name: Ubiquinone biosynthesis COQ7
reactant: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
fast: false
reversible: false
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110001#_cbbf3b33_2c1f_432b_9611_af3f7b13dc21
is encoded by: hsa:493
constant: false
name: ATP2B4
is: SBO:0000252
boundary condition: true
type: Species
initial amount: NaN
is: P23634
initial concentration: NaN
has only substance units: false

metaR RAI1
fast: false
reactant: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is: SBO:0000176
kinetic law: MODEL1310110001#
name: retinal isomerase (11-cis)
type: Reaction
reversible: true
product: MODEL1310110001#

metaM 3octdectecoa m
type: Species
is: http://identifiers.org/pubchem.compound/5280355
constant: false
boundary condition: false
name: 3,6,9,12-octadecatetraenoylcoa
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C39H58N7O17P3S CHARGE: -4

metaR NADPtru
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional output from ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
name: NADP transporter, endoplasmic reticulum
type: Reaction
product: MODEL1310110001#
reversible: false
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110001#_15409c81_4440_4d9c_a652_cd1e7ef5edb6
is: Q9UJS0
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:10165
has only substance units: false
is: SBO:0000252
boundary condition: true
name: SLC25A13

http://identifiers.org/biomodels.db/MODEL1310110001#_7d9c6c36_144d_4935_9b78_2dbc1309d2f1
has only substance units: false
initial concentration: NaN
name: COL4A3BP
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
is: Q9Y5P4
is encoded by: hsa:10087
boundary condition: true

metaR EX abt LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinitol exchange
type: Reaction

metaR RAI2
reactant: MODEL1310110001#
fast: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 5.2.1.3 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: retinal isomerase (9-cis)

metaR r1435
fast: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
name: Transport reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12930836,PMID:16288981,PMID:911815 NOTES:
reversible: false
reactant: MODEL1310110001#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_899e05ff_408d_4d46_b2d9_ae036b284389
initial concentration: NaN
constant: false
name: ALDH9A1
is encoded by: hsa:223
is: SBO:0000252
initial amount: NaN
is: P49189
type: Species
boundary condition: true
has only substance units: false

metaR r0998
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
name: Facilitated diffusion
reversible: true
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#

metaR r0885
fast: false
type: Reaction
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.1.38
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
modifier: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418,PMID:16600197,PMID:9639574 NOTES:
is: SBO:0000185
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110001#

metaR C160CPT1
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
modifier: MODEL1310110001#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:
name: production of Palmitoylcarnitine
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_29f4c16c_dabe_4dd2_a0e7_40a583f9bae8
is: C9JV30
boundary condition: true
is encoded by: hsa:3614
name: IMPDH1
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_32aaae0d_f112_4623_9b4d_fced3fab7922
type: Species
is: P14618
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:5315
name: PKM2

metaM gln L e
constant: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:18050
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
is: HMDB00641
name: L-glutamine
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_6e0b40e3_c2bf_43e0_b570_424628283d7d
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is encoded by: hsa:115
is: SBO:0000252
type: Species
is: O60503
name: ADCY9

http://identifiers.org/biomodels.db/MODEL1310110001#_7ed6a748_4e0b_483a_afdf_4d289d07b556
name: PLA2G12A
constant: false
is encoded by: hsa:81579
has only substance units: false
initial amount: NaN
type: Species
is: Q542Y6
is: SBO:0000252
boundary condition: true
initial concentration: NaN

metaR HESTRATRIOLtr
is: SBO:0000185
type: Reaction
reactant: MODEL1310110001#
fast: false
reversible: true
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism, hydroxylated (inactivated) estrogen derivative needs to be transported out of the cell NJ
product: MODEL1310110001#
is described by: ECO:0000000
name: hydroxylated estrogen derivative transport

metaM acnam c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00230
name: N-acetylneuraminate
is: SBO:0000247
constant: false
is: CHEBI:35418
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270

http://identifiers.org/biomodels.db/MODEL1310110001#_6fa2570c_8f81_40e6_84ee_2ead8fa53339
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:AA614647
name: _AA614647_1_c
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_cbf6822c_dbc7_4631_aab2_bc78ef3a7b16
initial amount: NaN
is: Q8NCL4
name: GALNT6
is encoded by: hsa:11226
has only substance units: false
is: SBO:0000252
type: Species
boundary condition: true
initial concentration: NaN
constant: false

metaR TYMSFt
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:SAB excretion of tyramine sulfate
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
reversible: false
name: Tyramine O-sulfate transport (diffusion)

http://identifiers.org/biomodels.db/MODEL1310110001#_a62524dd_74da_4ba5_88f7_74bc381ad360
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
type: Species
is encoded by: hsa:5730
is: P41222
name: PTGDS

metaR AG13T11g
reactant: MODEL1310110001#
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110001#

metaR r0999
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
is described by: ECO:0000000
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:1735445,PMID:18406340,PMID:1988962,PMID:2351134,PMID:2355017,PMID:6361812,PMID:7892212,PMID:8132483 NOTES:
reversible: true
type: Reaction
is: SBO:0000185
name: Facilitated diffusion

http://identifiers.org/biomodels.db/MODEL1310110001#_be3dfafc_5948_4d36_90bc_a179f0801f86
is: SBO:0000252
constant: false
is: Q96M32
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:122481
name: AK7

metaM pmtcrn x
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00222
initial concentration: 1.0
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
is: CHEBI:17490
name: L-palmitoylcarnitine

metaR 4HOXPACDOX NADP
is: SBO:0000176
modifier: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.2.1.5 Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
is described by: ECO:0000304
reactant: MODEL1310110001#
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
fast: false
type: Reaction
kinetic law: MODEL1310110001#

metaR FAOXC163C164x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C16:4)x
type: Reaction

metaR XYLTt
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:6821187 NOTES:NCD
name: Xylitol transport via passive diffusion
reversible: true
product: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#

metaR ESTRADIOLtr
product: MODEL1310110001#
name: estradiol intracellular transport
is: SBO:0000185
reversible: true
reactant: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ

metaM g2m8mpdol U r
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C1845H3040N20O720P20 CHARGE: -20
constant: false
is: SBO:0000247
is: CHEBI:59093
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_7b880408_0b38_4d4b_9eed_6331e35de6f3
is: Q9NUB1
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:84532
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
name: ACSS1

metaR S6TASE15ly
reversible: true
name: N-acetylglucosamine-6-sulfatase, lysosomal
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_fb0932c3_9705_4a09_9cd3_c34f19509583
constant: false
initial concentration: NaN
boundary condition: true
type: Species
has only substance units: false
name: PIK3R2
is encoded by: hsa:5296
is: SBO:0000252
initial amount: NaN
is: O00459

metaM dcyt c
notes: FORMULA: C9H13N3O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00574 EHMN_ABBREVIATION: C00881
name: Deoxycytidine
initial amount: NaN
is: CHEBI:15698
is: SBO:0000247
initial concentration: 1.0
is: HMDB00014
has only substance units: false
is: C00881
boundary condition: false
constant: false
type: Species

metaR LEULEULAPc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: hydrolysis of Leucylleucine in the small intestine for cellular uptake
type: Reaction

metaR G16MT L
name: Glycolipid 1,6-alpha-D-mannosyltransferase (liver)
kinetic law: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
product: MODEL1310110001#
reversible: false
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000176

metaM fuc1p L c
is: CHEBI:28319
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C6H11O8P CHARGE: -2 INCHI: InChI=1S/C6H13O8P/c1-2-3(7)4(8)5(9)6(13-2)14-15(10,11)12/h2-9H,1H3,(H2,10,11,12)/t2-,3+,4+,5-,6?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01030
is: HMDB01265
constant: false
name: L-Fucose 1-phosphate
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_2d510565_72a5_4e83_a21c_0d47f08de8fc
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: _J03866_1_m
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:J03866

metaR TETTET6t
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
reactant: MODEL1310110001#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
product: MODEL1310110001#

metaR FAOXC102C101m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: reduction(C10:2-->C10:1)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_4c2d7b31_6042_4981_949c_bb88ddb6e7d6
is: Q5JRA6
has only substance units: false
boundary condition: true
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
name: MIA3
is encoded by: hsa:375056
constant: false

metaR r1655
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#

metaM dlnlcg c
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
is: CHEBI:53486
has only substance units: false
type: Species
is: HMDB02925
name: dihomo-gamma-linolenic acid (n-6)
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_8cb32857_6edc_4fdc_9ea3_2c68b639509b
type: Species
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
name: _AD000092_1_c
is encoded by: hsa:AD000092
constant: false

metaR G14T5g
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8704.2) or (8704.1) or (8703.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
modifier: MODEL1310110001#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110001#
fast: false
is: SBO:0000176

metaR AMPtp
reversible: true
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:"diffusion" NJ
name: AMP transporter, peroxisome
kinetic law: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110001#
type: Reaction
fast: false

metaR C2tcx
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of acetylcarnitine from peroxisomes to cytosol
type: Reaction

metaR SMPD3g
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (55512.1) or (55512.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
product: MODEL1310110001#
is: SBO:0000176
fast: false
reactant: MODEL1310110001#
modifier: MODEL1310110001#
reversible: false
name: sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
is version of: http://identifiers.org/ec-code/3.1.4.12
type: Reaction
kinetic law: MODEL1310110001#

metaM gln L c
name: L-glutamine
initial concentration: 1.0
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
has only substance units: false
initial amount: NaN
boundary condition: false
is: HMDB00641
is: CHEBI:18050
type: Species
is: SBO:0000247
constant: false

metaR EX leuleu LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for leucylleucine
type: Reaction

metaM pan4p m
is: SBO:0000247
notes: FORMULA: C11H21N2O7PS CHARGE: -2 INCHI: InChI=1S/C11H23N2O7PS/c1-11(2,7-20-21(17,18)19)9(15)10(16)13-4-3-8(14)12-5-6-22/h9,15,22H,3-7H2,1-2H3,(H,12,14)(H,13,16)(H2,17,18,19)/p-2 HEPATONET_1.0_ABBREVIATION: HC00681 EHMN_ABBREVIATION: C01134
boundary condition: false
type: Species
is: HMDB01416
constant: false
has only substance units: false
name: pantetheine 4'-phosphate(2-)
is: CHEBI:47942
initial amount: NaN
initial concentration: 1.0

metaM xmp c
boundary condition: false
is: CHEBI:57464
initial concentration: 1.0
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C10H11N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00478 EHMN_ABBREVIATION: C00655
is: C00655
has only substance units: false
name: Xanthosine 5'-phosphate
is: HMDB01554
type: Species

metaR FACOAL246 1
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
product: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110001#
name: fatty-acid--CoA ligase
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#

metaM 3hexdtetcoa m
initial amount: NaN
is: SBO:0000247
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
name: 3,7,10,13-hexadecatetraenoylcoa
constant: false
boundary condition: false
is: HMDB02288
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_aabf6549_c6b4_4014_8422_09c9d6d24376
has only substance units: false
name: SLC35B2
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q8TB61
is encoded by: hsa:347734
type: Species
constant: false

metaR r1833
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
reversible: false
type: Reaction
fast: false

metaR r1656
fast: false
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000185

metaM pail45p hs n
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: CHEBI:28910
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: phosphatidylinositol 4,5-bisphosphate
initial concentration: 1.0

metaM acgal l
name: N-acetyl-D-galactosamine
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
is: HMDB00212
type: Species
boundary condition: false
is: CHEBI:28037
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132

http://identifiers.org/biomodels.db/MODEL1310110001#_4140221e_600d_459c_ba1d_264cc0649a6a
type: Species
name: ABCB4
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:5244
is: SBO:0000252
is: P21439
initial amount: NaN
has only substance units: false

metaR r0881
is: SBO:0000185
name: Active transport
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12107270,PMID:12739169,PMID:12829793,PMID:17245649,PMID:18375207,PMID:8476015,PMID:8557697,PMID:9786900 NOTES:
kinetic law: MODEL1310110001#
is described by: ECO:0000000

metaM h r
has only substance units: false
boundary condition: false
is: CHEBI:24636
initial amount: NaN
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3380
is: C00080
name: proton
type: Species
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: SBO:0000247

metaM hx2coa x
constant: false
name: trans-Hex-2-enoyl-CoA
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/11966188
is: HMDB06870
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H40N7O17P3S CHARGE: -4
is: C05998

metaR PSDm hs
notes: GENE_ASSOCIATION: (23761.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.1.1.65 Confidence Level: 4 AUTHORS: PMID:15052331,PMID:9370338 NOTES:modified from TV version for hs NJ
reversible: false
kinetic law: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.65
name: Phosphatidylserine decarboxylase
is described by: ECO:0000269
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#

metaM btamp c
has only substance units: false
name: Biotinyl-5'-AMP
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
is: HMDB04220
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: CHEBI:3110
type: Species
is: SBO:0000247

metaM dlnlcg e
constant: false
name: dihomo-gamma-linolenic acid (n-6)
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C20H33O2 CHARGE: -1 INCHI: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
initial concentration: 1.0
has only substance units: false
is: HMDB02925
boundary condition: false
is: CHEBI:53486

metaR GLYATm
type: Reaction
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (23464.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.3.1.29 Confidence Level: 2 AUTHORS: PMID:10712613 NOTES:
product: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.29
is: SBO:0000176
fast: false
reversible: true
name: glycine C-acetyltransferase
kinetic law: MODEL1310110001#

metaR r1657
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
reversible: true
is described by: ECO:0000000
product: MODEL1310110001#

metaR RE0583C
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110001#
name: RE0583
is: SBO:0000176
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10479480 NOTES:
product: MODEL1310110001#
is described by: ECO:0000000

metaM memgacpail hs r
is: SBO:0000247
is: CHEBI:15809
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
notes: FORMULA: C45H84N2O27P2FULLRCO2FULLR2CO2 CHARGE: 0
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)
initial amount: NaN
type: Species

metaR GLCSGLT1le
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of D-glucose from extracellular space to cytosol of mucosal cells in small intestine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_1e8ac27e_1bc4_4ef4_9f06_9d4d11b09c6b
is: P27144
initial concentration: NaN
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:205
has only substance units: false
type: Species
name: AK4

metaM pail45p hs m
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
is: CHEBI:28910
boundary condition: false
constant: false
name: phosphatidylinositol 4,5-bisphosphate
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM elaidcrn m
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
initial amount: NaN
name: Elaidic carnitine
is: HMDB06464
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false

metaR DADNt4
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:
fast: false
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110001#
name: deoxyadenosine transport via diffusion
product: MODEL1310110001#
is: SBO:0000185
kinetic law: MODEL1310110001#

metaM 2hexdtricoa x
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
boundary condition: false
constant: false
name: 2,7,10-hexadecatrienoylcoa
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110001#_58be8fb2_f5d2_461b_b07e_7f362703d12d
is: SBO:0000252
is encoded by: hsa:3098
has only substance units: false
is: B3KXY9
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
boundary condition: true
name: HK1

metaR C12DCTD
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of Dodecanedioic acid by diffusion
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_6af93c4f_d39c_4e21_ab0f_86ee86047529
boundary condition: true
constant: false
initial concentration: NaN
name: PECR
has only substance units: false
is encoded by: hsa:55825
type: Species
is: SBO:0000252
initial amount: NaN
is: Q9BY49

metaM 3sala m
is: CHEBI:61085
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C00606
has only substance units: false
name: 3-sulfino-L-alanine (1-)
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C3H5NO4S CHARGE: -2 INCHI: InChI=1S/C3H7NO4S/c4-2(3(5)6)1-9(7)8/h2H,1,4H2,(H,5,6)(H,7,8)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00451 EHMN_ABBREVIATION: C00606

http://identifiers.org/biomodels.db/MODEL1310110001#_d8cc9640_02c2_41db_8e77_ddfef59a63dd
initial amount: NaN
constant: false
initial concentration: NaN
name: PRDX1
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:5052

http://identifiers.org/biomodels.db/MODEL1310110001#_829496ee_a5b1_4410_9201_7e8af40a7588
type: Species
is encoded by: hsa:AA788780
constant: false
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
name: _AA788780_1_c

http://identifiers.org/biomodels.db/MODEL1310110001#_854cf669_39be_4561_9dc7_98a9224885c8
is: SBO:0000252
type: Species
initial concentration: NaN
name: SLC24A4
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:123041

http://identifiers.org/biomodels.db/MODEL1310110001#_9e1d2f58_c4cf_453a_ab46_359b82cedad9
is: SBO:0000252
initial amount: NaN
is: Q86VV3
is encoded by: hsa:953
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: ENTPD1
type: Species

metaM lthstrl r
has only substance units: false
is: HMDB01170
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00706 EHMN_ABBREVIATION: C01189
is: CHEBI:17168
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
name: 5alpha-cholest-7-en-3beta-ol
boundary condition: false

metaR r1658
is described by: ECO:0000000
reactant: MODEL1310110001#
fast: false
product: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
reversible: true
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction

metaR LCYSTAT
name: L-Cysteate:2-oxoglutarate aminotransferase
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#
reversible: true
is version of: http://identifiers.org/ec-code/2.6.1.1
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:described in PMID: 3346220 and KEGG MM
fast: false
type: Reaction
reactant: MODEL1310110001#

metaM adpcoa c
constant: false
initial concentration: 1.0
type: Species
is: C14143
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C27H39N7O19P3S CHARGE: -5
has only substance units: false
name: adipoylcoa
is: HMDB04047
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_624da270_1df8_43b2_93de_730fa264f820
is: P56134
name: ATP5J2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:9551

metaR LDH D
modifier: MODEL1310110001#
is: SBO:0000176
name: D-lactate dehydrogenase
fast: false
is described by: ECO:0000304
type: Reaction
reversible: true
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.2.4
notes: GENE_ASSOCIATION: (197257.1) or (197257.2) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.28 Confidence Level: 2 AUTHORS: PMID:11955284,PMID:12127981 NOTES:See also LDL_L. D-lactate metabolism measured in rat mitochondria; probably depend on D-LDH activity in matrix plus transport activity across mitochondrial membrane; putative human D-LDH cloned ; D-lactate formed in nanomolar concentrations via the methylglyoxal pathway; D- -hydroxy acid dehydrogenase (EC 1.1.99.6)

http://identifiers.org/biomodels.db/MODEL1310110001#_13c4424a_d777_40e4_86f4_a4579f40d61b
constant: false
has only substance units: false
name: _AI769281_1_e
initial amount: NaN
is encoded by: hsa:AI769281
boundary condition: true
type: Species
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_a5cee608_c5bd_4582_9d6c_568ba8020786
is: SBO:0000252
is encoded by: hsa:11238
name: CA5B
boundary condition: true
type: Species
has only substance units: false
is: Q9Y2D0
initial amount: NaN
initial concentration: NaN
constant: false

metaM h l
is: http://identifiers.org/pubchem.compound/3380
initial amount: NaN
boundary condition: false
name: proton
is: CHEBI:24636
is: C00080
has only substance units: false
notes: FORMULA: H CHARGE: 1 INCHI: "
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species

metaR S2TASE1ly
name: iduronate-2-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
reactant: MODEL1310110001#
reversible: false
is: SBO:0000176
fast: false
product: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.13
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000

metaM btamp m
notes: FORMULA: C20H27N7O9PS CHARGE: -1 INCHI: InChI=1S/C20H28N7O9PS/c21-17-14-18(23-7-22-17)27(8-24-14)19-16(30)15(29)10(35-19)5-34-37(32,33)36-12(28)4-2-1-3-11-13-9(6-38-11)25-20(31)26-13/h7-11,13,15-16,19,29-30H,1-6H2,(H,32,33)(H2,21,22,23)(H2,25,26,31)/t9-,10+,11-,13-,15+,16+,19+/m0/s1 EHMN_ABBREVIATION: C05921
boundary condition: false
is: HMDB04220
has only substance units: false
initial concentration: 1.0
name: Biotinyl-5'-AMP
type: Species
is: CHEBI:3110
is: SBO:0000247
constant: false
initial amount: NaN

metaR FAOXC163C142x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:2)x
type: Reaction

metaM xol7ah3 m
constant: false
name: 5beta-cholestane-3alpha,7alpha,26-triol
is: CHEBI:28540
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: HMDB12455
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h17-25,28-30H,5-16H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01453 EHMN_ABBREVIATION: C05444
type: Species
boundary condition: false

metaR CYTK13
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dATP)
type: Reaction
product: MODEL1310110001#

metaM gmp c
is: C00144
initial amount: NaN
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C10H12N5O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00141 EHMN_ABBREVIATION: C00144
constant: false
name: GMP
is: CHEBI:58115
is: HMDB01397
type: Species
is: SBO:0000247
has only substance units: false

metaR DOLPGT2 Ler
is: SBO:0000176
is described by: ECO:0000000
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase (liver)
notes: GENE_ASSOCIATION: (79053.1) or (79053.3) or (79053.2) SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC 2.4.1.- NCD
is version of: http://identifiers.org/ec-code/2.4.1.265
type: Reaction
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
reversible: false
product: MODEL1310110001#

metaR RE3346C
kinetic law: MODEL1310110001#
name: RE3346
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110001#
is described by: ECO:0000000
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (223.1) or (218.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:1591235 NOTES:
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_34c3104e_aea3_4cb4_8994_b0d157dfe5af
has only substance units: false
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
is: Q8WWT9
is encoded by: hsa:64849
type: Species
name: SLC13A3
initial concentration: NaN

metaM triodthy c
constant: false
boundary condition: false
name: 3,3',5-triiodo-L-thyronine
initial amount: NaN
is: CHEBI:18258
is: SBO:0000247
has only substance units: false
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
type: Species
is: HMDB00265
initial concentration: 1.0

metaM pmtcrn r
initial concentration: 1.0
is: HMDB00222
is: SBO:0000247
name: L-palmitoylcarnitine
boundary condition: false
has only substance units: false
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990
initial amount: NaN
constant: false
is: CHEBI:17490
type: Species

metaR RE3565C
name: RE3565
type: Reaction
reactant: MODEL1310110001#
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:

metaR FRUt1r
fast: false
is described by: ECO:0000269
reactant: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (29988.1) or (6514.1) or (155184.1) or (6518.1) or (66035.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10821868,PMID:10860996,PMID:11583593,PMID:11780753,PMID:11882499,PMID:12135767,PMID:12750891,PMID:15033637,PMID:1634504,PMID:1695905,PMID:1701966,PMID:2182619,PMID:3399500,PMID:8419132,PMID:9770484 NOTES:NCD
name: D-fructose transport in via uniport
kinetic law: MODEL1310110001#
is: SBO:0000185
reversible: true

metaM h m
notes: FORMULA: H CHARGE: 1 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
name: proton
is: CHEBI:24636
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/3380
is: SBO:0000247
type: Species
boundary condition: false
is: C00080
initial amount: NaN
initial concentration: 1.0

metaM acgal c
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
name: N-acetyl-D-galactosamine
type: Species
is: HMDB00212
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6+,7-,8?/m1/s1 EHMN_ABBREVIATION: C01132
boundary condition: false
is: CHEBI:28037

metaR CYTK14
kinetic law: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
name: cytidylate kinase (dCMP,UTP)
product: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269
reactant: MODEL1310110001#
type: Reaction

metaM l2fn2m2masn g
notes: FORMULA: C68H113N4O49X CHARGE: 0
has only substance units: false
initial concentration: 1.0
constant: false
name: {[galactosyl-(1,4)-N-Acetyl-glucosaminyl-(1,2)-mannosyl-(1,3)-],[N-acetyl-glucosaminyl-(1,2)-mannosyl-(1,6)-]mannosyl-(1,4)-N-acetyl-glucosaminyl-(1,4)-[fucosyl-(1,6)]-N-acetyl-glucosaminyl}asparagine
type: Species
is: SBO:0000247
boundary condition: false
is: CHEBI:28067
initial amount: NaN

metaR r0993
reversible: false
type: Reaction
is: SBO:0000185
name: ATP-binding Cassette (ABC) TCDB:3.A.1.208.2
kinetic law: MODEL1310110001#
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14716480,PMID:15209530,PMID:15297262 NOTES:
reactant: MODEL1310110001#
product: MODEL1310110001#

metaR PPD2CSPp
fast: false
kinetic law: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:spontaneous cyclization reaction MM
name: PPD2CSPp
reversible: false
reactant: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#
is: SBO:0000176

metaR SAMHISTA
product: MODEL1310110001#
is: SBO:0000176
reversible: false
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
notes: GENE_ASSOCIATION: (3176.1) SUBSYSTEM: Histidine metabolism EC Number: 2.1.1.8 Confidence Level: 4 AUTHORS: PMID:7943261 NOTES:SAB R02155
type: Reaction
reactant: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/2.1.1.8
is described by: ECO:0000269
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#

metaM dhf c
is: HMDB01056
is: CHEBI:57451
notes: FORMULA: C19H19N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00340 EHMN_ABBREVIATION: C00415
name: 7,8-Dihydrofolate
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: C00415
constant: false
type: Species
initial concentration: 1.0
boundary condition: false

metaR EX sucr LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sucrose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_307b7cbd_fddc_4dd7_9f42_1b8da6bc04de
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
is: P06865
is: SBO:0000252
name: HEXA
initial amount: NaN
type: Species
is encoded by: hsa:3073

metaR r1832
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110001#
is: SBO:0000185
fast: false
reactant: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
name: Y+LAT2 Utilized transport
product: MODEL1310110001#

metaR CYTK8n
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110001#
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110001#
name: cytidylate kinase (CMP,dATP),nuclear
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
modifier: MODEL1310110001#
fast: false
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_cddce557_4a6e_498d_bea2_23ef377bcb12
initial concentration: NaN
constant: false
initial amount: NaN
boundary condition: true
type: Species
name: INPP5J
is: SBO:0000252
is encoded by: hsa:27124
has only substance units: false

metaR AGTim
name: alanine-glyoxylate transaminase (irreversible), mitochondrial
modifier: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (64902.1) or (64850.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.44 Confidence Level: 4 AUTHORS: PMID:15240345,PMID:9038835,PMID:9783918 NOTES:NCD
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/2.6.1.44
is described by: ECO:0000269
type: Reaction
reactant: MODEL1310110001#

metaM ksii core2 pre8 g
is: C00130
type: Species
boundary condition: false
is: HMDB00175
initial amount: NaN
constant: false
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 8
notes: FORMULA: C75H121N6O56SX CHARGE: -2
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_ab2b5fdc_69a1_4e74_a9af_e9e62b64e16b
type: Species
initial amount: NaN
name: PDE9A
is: SBO:0000252
is encoded by: hsa:5152
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_adba5c98_748b_40eb_b38c_b23fcd243023
initial concentration: NaN
type: Species
is: O43678
is encoded by: hsa:4695
name: NDUFA2
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false

metaM h n
initial amount: NaN
type: Species
name: proton
has only substance units: false
initial concentration: 1.0
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
is: CHEBI:24636
constant: false
is: SBO:0000247
boundary condition: false

metaR FAOXC101C8x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C8:0)x
type: Reaction

metaR EX tetpent3 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-3 exchange
type: Reaction

metaR r0990
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:10884298,PMID:6469982 NOTES:
type: Reaction
reactant: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
is described by: ECO:0000000
name: Postulated transport reaction

metaR PROD2
product: MODEL1310110001#
is: SBO:0000176
fast: false
reactant: MODEL1310110001#
is described by: ECO:0000254
kinetic law: MODEL1310110001#
reversible: false
notes: GENE_ASSOCIATION: (58510.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR
name: Proline dehydrogenase
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.5.99.8
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_9bef7450_75d6_4ccb_a550_9653a7ed7ad6
name: PMM1
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
is: A8K003
type: Species
is: SBO:0000252
is encoded by: hsa:5372
initial concentration: NaN

metaR C4tcx
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of bytyrylcarnitine from peroxisomes
type: Reaction

metaM ha deg1 l
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
name: hyaluronan degradation product 1
notes: FORMULA: C22H33N2O16 CHARGE: -1
has only substance units: false
is: SBO:0000247
is: CHEBI:16336

metaM betald c
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: CHEBI:15710
constant: false
notes: FORMULA: C5H12NO CHARGE: 1 INCHI: InChI=1S/C5H12NO/c1-6(2,3)4-5-7/h5H,4H2,1-3H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00435 EHMN_ABBREVIATION: C00576
is: HMDB01252
name: betaine aldehyde

metaM dnad c
constant: false
is: CHEBI:18304
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C21H24N6O15P2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00564 EHMN_ABBREVIATION: C00857
name: Deamino-NAD+
is: HMDB01179
initial concentration: 1.0
type: Species
boundary condition: false
is: C00857

metaR r0276
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.2
type: Reaction
is: SBO:0000176
product: MODEL1310110001#
fast: false
name: NADH:guanosine-5-phosphate oxidoreductase(deaminating) Purine metabolism EC:1.7.1.7
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.21
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (10327.1) or (231.1) SUBSYSTEM: Purine catabolism EC Number: 1.7.1.7 Confidence Level: 0 AUTHORS: PMID:12009299,PMID:12669231 NOTES:
reversible: true
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_a8b1f980_dea2_4111_be29_43cb19e56154
initial amount: NaN
is encoded by: hsa:506
constant: false
boundary condition: true
name: ATP5B
initial concentration: NaN
is: SBO:0000252
is: P06576
type: Species
has only substance units: false

metaR ILETA
name: isoleucine transaminase
type: Reaction
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.42 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:
reactant: MODEL1310110001#
fast: false
reversible: true
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.6.1.42
modifier: MODEL1310110001#

metaM triodthy e
type: Species
is: HMDB00265
initial amount: NaN
notes: FORMULA: C15H12I3NO4 CHARGE: 0 INCHI: InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00943 EHMN_ABBREVIATION: C02465
is: CHEBI:18258
has only substance units: false
name: 3,3',5-triiodo-L-thyronine
constant: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_f0c7e7ac_9e54_4008_baa3_2a71d14306e2
is: Q5QPH3
constant: false
name: ACSS2
has only substance units: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55902
boundary condition: true
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_510ceff9_06f9_41f9_b7c2_07388fa2f592
is: Q75T13
is encoded by: hsa:80055
boundary condition: true
type: Species
has only substance units: false
constant: false
is: SBO:0000252
name: PGAP1
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_14e4c95b_81f9_4cb2_bc40_3c3f607fd4f4
initial amount: NaN
is encoded by: hsa:6652
name: SORD
type: Species
initial concentration: NaN
is: Q00796
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false

metaR G6PPer
modifier: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.9
kinetic law: MODEL1310110001#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 3.1.3.9 Confidence Level: 4 AUTHORS: PMID:10078553,PMID:11297555,PMID:12370122,PMID:12965222,PMID:13129915,PMID:15044018,PMID:8211187,PMID:8407995,PMID:9497333 NOTES:NCD
product: MODEL1310110001#
is: SBO:0000176
fast: false
name: glucose-6-phosphate phosphatase, edoplasmic reticular
reversible: false
reactant: MODEL1310110001#

metaM nadph r
is: CHEBI:57783
is: C00005
type: Species
is: HMDB00221
is: SBO:0000247
name: Nicotinamide adenine dinucleotide phosphate - reduced
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C21H26N7O17P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00015 EHMN_ABBREVIATION: C00005
has only substance units: false
initial amount: NaN
constant: false

metaM gln L m
boundary condition: false
is: HMDB00641
initial concentration: 1.0
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:18050
name: L-glutamine
notes: FORMULA: C5H10N2O3 CHARGE: 0 INCHI: InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00067
constant: false
initial amount: NaN

metaM gm3 hs g
notes: FORMULA: C41H72N2O20FULLRCO CHARGE: -1 EHMN_ABBREVIATION: C04730
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:60065
name: alpha-N-acetylneuraminosyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide(1-)
has only substance units: false

metaM acgam r
boundary condition: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: SBO:0000247
is: CHEBI:17411
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: N-acetyl-D-glucosamine
initial concentration: 1.0
is: HMDB00215

metaR ADNt4
name: adenosine transport (Na/Adn cotransport)
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9154.2) or (9154.1) or (64078.1) or (9153.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856181 NOTES:MM
is described by: ECO:0000269
fast: false
modifier: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#

metaM alpa hs c
notes: FORMULA: C3H6O5PFULLRCO2 CHARGE: -2 INCHI: InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)
is: CHEBI:52288
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
name: lysophosphatidic acid
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_621e3506_f5a7_4e53_90d2_39f8f4be9bef
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:AI971023
boundary condition: true
name: _AI971023_1_c
type: Species
initial concentration: NaN
initial amount: NaN

metaR SUCCtp
type: Reaction
name: succinate transporter, peroxisome
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
reactant: MODEL1310110001#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_da12fad5_894f_4747_b837_fa0f23a2b9b1
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:761
initial concentration: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
name: CA3
is: P07451

http://identifiers.org/biomodels.db/MODEL1310110001#_4dde98cb_35b1_4b61_951e_5aeeae4340f2
is encoded by: hsa:6817
name: SULT1A1
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
constant: false

metaR G16MT U
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
product: MODEL1310110001#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110001#
name: Glycolipid 1,6-alpha-D-mannosyltransferase (uterus)
type: Reaction
fast: false
reactant: MODEL1310110001#

metaR EX xyl D LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Xylose exchange
type: Reaction

metaR r0129
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
reactant: MODEL1310110001#
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.1.40
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
fast: false
type: Reaction
is: SBO:0000176
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_b0f56246_bd5d_403e_b390_9ee0cf754993
is: A8K460
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:8398
initial amount: NaN
constant: false
has only substance units: false
name: PLA2G6
type: Species
boundary condition: true

metaM pail45p hs c
initial amount: NaN
is: CHEBI:28910
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5 EHMN_ABBREVIATION: C04637
type: Species
name: phosphatidylinositol 4,5-bisphosphate

metaR r2132
reversible: true
fast: false
modifier: MODEL1310110001#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_2bf09d7f_51b1_42bd_8ada_2efda86cc6fd
has only substance units: false
name: SLC29A2
initial amount: NaN
type: Species
constant: false
is: Q14542
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3177

http://identifiers.org/biomodels.db/MODEL1310110001#_dc85df84_a568_416a_ba54_1472c4da7462
initial amount: NaN
is: O15120
type: Species
has only substance units: false
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:10555
boundary condition: true
name: AGPAT2

metaM decdp c
is: SBO:0000247
boundary condition: false
name: all trans Decaprenyl diphosphate
constant: false
notes: FORMULA: C50H81O7P2 CHARGE: -3 INCHI: InChI=1/C50H90O7P2/c1-41(2)21-31-53-58(51,54-32-22-42(3)4)57-59(52,35-25-45(9)10,36-26-46(11)12,37-27-47(13)14,38-28-48(15)16,39-29-49(17)18,40-30-50(19)20,55-33-23-43(5)6)56-34-24-44(7)8/h21-30H,31-40H2,1-20H3
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB06288

metaM sbcoa x
constant: false
boundary condition: false
name: suberylcoa
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/16019966
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C29H43N7O19P3S CHARGE: -5

metaM ala D e
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
type: Species
is: HMDB01310
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
name: D-alanine
has only substance units: false
is: CHEBI:15570

metaR C160CPT2
kinetic law: MODEL1310110001#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110001#
is: SBO:0000176
name: C160 transport into the mitochondria
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_4a200870_626f_4938_a8d8_7132b9c12613
name: PDE9A
boundary condition: true
is encoded by: hsa:5152
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: NaN

metaM c12dc x
constant: false
notes: FORMULA: C19H34NO6 CHARGE: -1
is: SBO:0000247
name: dodecanedioyl carnitine
boundary condition: false
has only substance units: false
is: HMDB11123
is: C05279
initial amount: NaN
type: Species
initial concentration: 1.0

metaM ksi pre32 g
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 32
initial amount: NaN
type: Species
notes: FORMULA: C227H362N16O192S10X CHARGE: -11
boundary condition: false
is: CHEBI:28067

metaR EX 3ivcrn
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-isovaleryl carnitine
type: Reaction

metaR CORE6GTg
is: SBO:0000176
notes: GENE_ASSOCIATION: (2650.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:9915862 NOTES:NCD
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110001#
product: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
reversible: false
name: Core 6 beta-GlcNAc-transferase A, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.102
kinetic law: MODEL1310110001#

metaR r1946
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
product: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#
reversible: false
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_30db3c8b_d011_47f2_8216_76c8ba22dc50
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:3418
is: P48735
type: Species
name: IDH2
is: SBO:0000252
initial amount: NaN

metaR FAOXC18C18OHm
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18-->C18OH)m
type: Reaction

metaR OIVD1m
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.2.4.4
is version of: http://identifiers.org/ec-code/2.3.1.168
is version of: http://identifiers.org/ec-code/1.8.1.4
name: 2-oxoisovalerate dehydrogenase (acylating; 4-methyl-2-oxopentaoate), mitochondrial
kinetic law: MODEL1310110001#
fast: false
product: MODEL1310110001#
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110001#
type: Reaction

metaR r2133
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110001#
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_4cba7d21_e32e_4c88_87d9_0f3ac24b00fd
type: Species
boundary condition: true
constant: false
name: SLC2A1
is: P11166
has only substance units: false
initial amount: NaN
is encoded by: hsa:6513
initial concentration: NaN
is: SBO:0000252

metaM pmtcrn m
has only substance units: false
initial concentration: 1.0
boundary condition: false
name: L-palmitoylcarnitine
constant: false
is: CHEBI:17490
initial amount: NaN
is: SBO:0000247
type: Species
is: HMDB00222
notes: FORMULA: C23H45NO4 CHARGE: 0 INCHI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01034 EHMN_ABBREVIATION: C02990

http://identifiers.org/biomodels.db/MODEL1310110001#_300b0307_de4b_456a_83b4_17a316008533
name: _AI631997_1_m
has only substance units: false
is: SBO:0000252
is encoded by: hsa:AI631997
boundary condition: true
initial concentration: NaN
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_032e1c8f_1976_4b7b_ba5e_4ad2f1bef344
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
type: Species
name: ITPKB
has only substance units: false
initial concentration: NaN
is encoded by: hsa:3707
is: P27987

metaR GLUDxm
reversible: true
is version of: http://identifiers.org/ec-code/1.4.1.3
modifier: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
fast: false
name: glutamate dehydrogenase (NAD) (mitochondrial)
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.3 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
kinetic law: MODEL1310110001#
is described by: ECO:0000269

metaR DMHPTCRNCPT2
reactant: MODEL1310110001#
is: SBO:0000176
name: 2,6 dimethylheptanoly CoA carnitine transferase
fast: false
product: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9819701 NOTES:made reversible since Keq ~ 0.6. dmhptcoa is a special case because its biochemical fate has not be elucidated. NJ
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_1fb118f7_4e82_41c6_83cd_8585f79c2640
type: Species
initial amount: NaN
is: SBO:0000252
name: ST3GAL1
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6482

metaM 3hexdtetcoa x
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
name: 3,7,10,13-hexadecatetraenoylcoa
constant: false
is: HMDB02288

metaR CYTDK2m
reversible: false
name: cytidine kinase (ATP), mitochondrial
kinetic law: MODEL1310110001#
fast: false
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: NOTES:IT
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction

metaR r0994
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:15975683 NOTES:
type: Reaction
reversible: true
product: MODEL1310110001#
name: Facilitated diffusion
reactant: MODEL1310110001#
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110001#

metaM elaidcrn c
is: HMDB06464
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
name: Elaidic carnitine
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/b13-12+
is: SBO:0000247
has only substance units: false

metaM HC00695 m
is: CHEBI:17432
is: SBO:0000247
has only substance units: false
constant: false
initial concentration: 1.0
name: S-Succinyldihydrolipoamide
initial amount: NaN
notes: FORMULA: C12H20NO4S2 CHARGE: -1 INCHI: InChI=1S/C12H21NO4S2/c13-10(14)4-2-1-3-9(18)7-8-19-12(17)6-5-11(15)16/h9,18H,1-8H2,(H2,13,14)(H,15,16) EHMN_ABBREVIATION: C01169
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_a01c172b_a015_441c_b63f_669e2963a918
initial amount: NaN
constant: false
name: MTHFD1L
is encoded by: hsa:25902
is: SBO:0000252
has only substance units: false
type: Species
is: B2RD24
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_dde8d375_7df1_424a_bc8d_f460cac75f9c
boundary condition: true
is encoded by: hsa:47
name: ACLY
constant: false
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

metaR DOPASULT
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.8.2.1
notes: GENE_ASSOCIATION: (6799.1) or (6817.3) or (6799.2) or (6818.2) or (6817.2) or (6818.1) or (6817.1) or (6817.4) or (6818.3) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:RS/TV (6/14/2005)
is described by: ECO:0000269
modifier: MODEL1310110001#
type: Reaction
reversible: false
fast: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000176
name: Dopamine Sulfotransferase

metaR r2130
fast: false
modifier: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000000
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110001#_b42a5c85_bf5c_4702_b0e4_ec3380e81e99
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:4199
type: Species
name: ME1
is: P48163
constant: false
has only substance units: false

metaR AKGtp
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
fast: false
name: AKG transporter, peroxisome
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_ec783dfd_35c7_4b9c_883c_1c28bff2deb9
has only substance units: false
boundary condition: true
initial amount: NaN
type: Species
initial concentration: NaN
has part: Q9NY65
is encoded by: hsa:1962
name: EHHADH:ACAA1:ACOX1
constant: false
is: SBO:0000297

metaR DM gpi sig er
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gpi sig(er)
type: Reaction

metaR 3HBCDm
is described by: ECO:0000254
fast: false
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (55268.1) SUBSYSTEM: Butanoate metabolism EC Number: 4.2.1.55 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:NCD. rat gene that is homologous to the human gene encodes for this activity
name: 3-hydroxybutyryl-CoA dehydratase, mitochondrial
is: SBO:0000176
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_2382495a_5531_4773_a7a9_7cf7e440e8ae
initial concentration: NaN
type: Species
constant: false
boundary condition: true
has only substance units: false
is: P56181
name: NDUFV3
initial amount: NaN
is encoded by: hsa:4731
is: SBO:0000252

metaR D LACt2
is: SBO:0000185
type: Reaction
modifier: MODEL1310110001#
reversible: true
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9194.1) or (23539.1) or (6566.1) or (9123.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10493836,PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:JLR
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: D-lactate transport via proton symport
fast: false
reactant: MODEL1310110001#

metaM ala D c
is: CHEBI:15570
is: SBO:0000247
boundary condition: false
initial amount: NaN
type: Species
constant: false
notes: FORMULA: C3H7NO2 CHARGE: 0 INCHI: InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m1/s1
has only substance units: false
name: D-alanine
is: HMDB01310
initial concentration: 1.0

metaR MANt1r
reactant: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
reversible: true
is described by: ECO:0000269
name: mannose transport (uniport)
is: SBO:0000185
type: Reaction
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (6513.1) or (6515.1) or (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3399500,PMID:3839598,PMID:7926364,PMID:9770484 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110001#_d8bc59d7_481f_42d2_8e0e_6d82f5442f7d
initial amount: NaN
has only substance units: false
constant: false
type: Species
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: _R06874_1_r
is encoded by: hsa:R06874

metaR DDECCRNe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of lauroyl carnitine into extra cellular space
type: Reaction

metaR Htx
fast: false
reversible: true
is: SBO:0000185
name: H transporter, peroxisome
kinetic law: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000
reactant: MODEL1310110001#

metaR NTD10
name: 5'-nucleotidase (XMP)
type: Reaction
reversible: false
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.3.5
modifier: MODEL1310110001#
is described by: ECO:0000254
product: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (22978.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.5 Confidence Level: 2 AUTHORS: PMID:15699053 NOTES:Wide specificity for 5'-nucleotides Also see EC 3.1.3.31. Rat

metaM 3tetd7ecoa m
name: 3-hydroxy tetradecenoyl-7-coa
initial amount: NaN
notes: FORMULA: C35H56N7O18P3S CHARGE: -4
is: HMDB05066
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
boundary condition: false
is: SBO:0000247

metaR r2131
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
kinetic law: MODEL1310110001#

metaR r0311
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110001#
name: Palmitate:CoA ligase (AMP-forming) Fatty acid metabolism EC:6.2.1.3
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (38.1) or (39.1) or (3032.1) or (4645.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
fast: false
is: SBO:0000176
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.9
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.16

http://identifiers.org/biomodels.db/MODEL1310110001#_06031008_7e77_4f76_b162_fb89ceb72379
constant: false
is: SBO:0000252
type: Species
has only substance units: false
name: PIPOX
initial concentration: NaN
boundary condition: true
is: Q9P0Z9
initial amount: NaN
is encoded by: hsa:51268

metaR GALASE8ly
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110001#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
name: beta-galactosidase, lysosomal
fast: false
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.18
is: SBO:0000176
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110001#_11e56470_96aa_4743_b1ba_b8f40457b1ac
has only substance units: false
is encoded by: hsa:10396
initial concentration: NaN
is: Q9Y2Q0
type: Species
name: ATP8A1
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM udpglcur r
is: SBO:0000247
boundary condition: false
is: C00167
initial amount: NaN
is: CHEBI:58052
constant: false
name: UDP-D-glucuronate
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
has only substance units: false
is: HMDB00935
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_32e5eee7_0bd5_47f3_8771_2f7c95538a7e
initial amount: NaN
has only substance units: false
is: D3DX95
initial concentration: NaN
constant: false
name: CHAT
is encoded by: hsa:1103
boundary condition: true
is: SBO:0000252
type: Species

metaR r2111
reactant: MODEL1310110001#
reversible: true
is: SBO:0000185
fast: false
kinetic law: MODEL1310110001#
is described by: ECO:0000000
modifier: MODEL1310110001#
product: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_6e1bfdb8_83ee_4c3d_8dd0_69b91a1d9aea
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P31040
is encoded by: hsa:6389
type: Species
name: SDHA
constant: false
initial amount: NaN
is: SBO:0000252

metaR MALTe
name: alpha-glucosidase, extracellular
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (8972.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.20 Confidence Level: 4 AUTHORS: PMID:3143729 NOTES:IF
modifier: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000269
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.20
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_0a855f40_2561_46ad_969d_8e9e747e2fb4
is: SBO:0000252
initial amount: NaN
type: Species
is encoded by: hsa:353
boundary condition: true
name: APRT
constant: false
is: P07741
has only substance units: false
initial concentration: NaN

metaR BTNPL
name: holocarboxylase synthestase (biotin protein ligase)
reversible: false
fast: false
is: SBO:0000176
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.3.4.10
type: Reaction
product: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (3141.1) SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:IT for human biotin metabolism
kinetic law: MODEL1310110001#
is described by: ECO:0000000

metaM pa hs c
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57739
name: phosphatidate(2-)
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
initial concentration: 1.0
constant: false
type: Species

metaR r1928
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reactant: MODEL1310110001#
reversible: false
is: SBO:0000185
modifier: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#
type: Reaction
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_b7bf3bc3_dc33_4560_b589_9fce349bb984
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:9107
initial amount: NaN
is: Q9Y217
name: MTMR6
is: SBO:0000252
type: Species

metaM dgtp c
name: dGTP
is: HMDB01440
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
is: CHEBI:16497
has only substance units: false
is: C00286
initial concentration: 1.0
is: SBO:0000247
constant: false
type: Species
initial amount: NaN
boundary condition: false

metaR r2110
kinetic law: MODEL1310110001#
type: Reaction
reversible: true
product: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110001#
is: SBO:0000185
modifier: MODEL1310110001#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_7f9227d1_8875_42b2_8b40_0651c38e31b3
initial concentration: NaN
is: P00374
constant: false
type: Species
initial amount: NaN
name: DHFR
boundary condition: true
is: SBO:0000252
is encoded by: hsa:1719
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_46d1f5c2_a5cb_462f_9db4_3b479a2f6607
type: Species
boundary condition: true
is: SBO:0000252
is: B4E0V8
constant: false
name: HAL
initial amount: NaN
is encoded by: hsa:3034
initial concentration: NaN
has only substance units: false

metaR TDPm
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: 3.6.1.15 Confidence Level: 2 AUTHORS: PMID:9755848 NOTES:_01-25-05 IT
reversible: false
fast: false
product: MODEL1310110001#
name: thiamin pyrophosphatase, mitochondrial
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_7dc3665e_3430_4d12_b25a_e8fedd2934a4
boundary condition: true
has only substance units: false
name: NDUFV1
is: E5KNH5
initial amount: NaN
is encoded by: hsa:4723
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_fa1244e7_123a_44c0_ba17_6f78b1975c4e
initial concentration: NaN
is: Q9NVS9
type: Species
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: PNPO
has only substance units: false
is encoded by: hsa:55163

metaR FACOAL181i
fast: false
kinetic law: MODEL1310110001#
is described by: ECO:0000269
name: C181 fatty acid activation
is: SBO:0000176
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:TV catalyzed by acyl-CoA synthetases
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110001#
reversible: false
type: Reaction
product: MODEL1310110001#

metaR BILDGLCURtr
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism, however glucuronidated metabolites need to get out of the cell NJ
reversible: true
kinetic law: MODEL1310110001#
is: SBO:0000185
type: Reaction
name: glucuronidated compound transport
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_5c5f335b_2f80_4839_a30b_ddba0c76cf05
initial concentration: NaN
name: LDHA
is: SBO:0000252
constant: false
is: P00338
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
is encoded by: hsa:3939

metaR AKR1D
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ
is version of: http://identifiers.org/ec-code/1.3.1.3
is described by: ECO:0000269
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
type: Reaction
is: SBO:0000176

metaR HPACtr
name: hydroxyphenylacetate transport via diffusion
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:3753983 NOTES:SAB
reversible: true
product: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false

metaM btn e
initial concentration: 1.0
notes: FORMULA: C10H15N2O3S CHARGE: -1
is: HMDB00030
constant: false
initial amount: NaN
has only substance units: false
name: Biotin
boundary condition: false
is: C00120
is: SBO:0000247
type: Species
is: CHEBI:3420

http://identifiers.org/biomodels.db/MODEL1310110001#_2230fc92_516e_4bfe_8289_23bed0e09bd7
is: Q3I5F7
is encoded by: hsa:641372
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: ACOT6
constant: false
is: SBO:0000252
type: Species
boundary condition: true

metaR r0119
is described by: ECO:0000000
name: Guanosine 5-triphosphate pyrophosphohydrolase Purine metabolism EC:3.6.1.19
is version of: http://identifiers.org/ec-code/5.1.3.14
reversible: false
type: Reaction
is: SBO:0000176
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (10020.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:11278832,PMID:4310599 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_46a5cc69_23ca_4733_b44f_27d4ca07e48e
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
name: FOLR1
constant: false
initial amount: NaN
is encoded by: hsa:2348
is: SBO:0000252

metaR SPODM
is described by: ECO:0000269
product: MODEL1310110001#
reactant: MODEL1310110001#
name: superoxide dismutase
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
kinetic law: MODEL1310110001#
type: Reaction
fast: false
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.15.1.1
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_7159312e_492e_4b4a_9ef2_7d490f6d7dd4
type: Species
is encoded by: hsa:7108
boundary condition: true
is: SBO:0000252
has only substance units: false
initial amount: NaN
is: O76062
initial concentration: NaN
name: TM7SF2
constant: false

metaR ARAB Lt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12359133,PMID:15234337,PMID:2167807 NOTES:
name: L-arabinoase extracellular transport
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reversible: true

metaR r2113
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110001#
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110001#

metaR SCP22x
reversible: true
name: Sterol carrier protein 2
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.176
is: SBO:0000185
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
kinetic law: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#
reactant: MODEL1310110001#
modifier: MODEL1310110001#
fast: false

metaM HC01434 x
constant: false
is: CHEBI:58931
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species
name: oxalatosuccinate(3-)
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379

metaR DLNLCGCPT1
modifier: MODEL1310110001#
name: carnitine O-palmitoyltransferase
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#

metaM acgam l
name: N-acetyl-D-glucosamine
is: CHEBI:17411
has only substance units: false
initial concentration: 1.0
is: HMDB00215
constant: false
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247

metaM 4hpro LT m
constant: false
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
has only substance units: false
initial concentration: 1.0
name: trans-4-hydroxy-L-proline
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:18095
is: HMDB00725
boundary condition: false

metaM ksi deg4 l
is: SBO:0000247
initial concentration: 1.0
name: keratan sulfate I, degradation product 4
constant: false
initial amount: NaN
boundary condition: false
is: CHEBI:57737
type: Species
has only substance units: false
is: HMDB00868
notes: FORMULA: C222H355N15O197S12 CHARGE: -12

metaR EX acetone LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetone exchange
type: Reaction

metaM g3p c
type: Species
initial concentration: 1.0
name: Glyceraldehyde 3-phosphate
is: HMDB01112
is: SBO:0000247
constant: false
is: C00661
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3930
boundary condition: false
is: CHEBI:58027
has only substance units: false
notes: FORMULA: C3H5O6P CHARGE: -2 INCHI: " HEPATONET_1.0_ABBREVIATION: HC00116

http://identifiers.org/biomodels.db/MODEL1310110001#_c86bc54b_febc_4c01_989c_8911587170f5
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
type: Species
name: ETFB
is encoded by: hsa:2109
initial amount: NaN
has only substance units: false

metaR FUMtm
reactant: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:3587497 NOTES:TDV
modifier: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
fast: false
kinetic law: MODEL1310110001#
name: fumarate transport, mitochondrial

metaR LDH L
type: Reaction
is described by: ECO:0000000
product: MODEL1310110001#
modifier: MODEL1310110001#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.27
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
name: L-lactate dehydrogenase
notes: GENE_ASSOCIATION: (3945.1 and 3939.1) or (160287.1) or (3948.2) or (3939.1) or (3948.1) or (55293.1) or (3945.1) or (92483.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:11377399,PMID:15240094,PMID:2440048 NOTES:Also see LDL_D
is: SBO:0000176
fast: false

metaM 4hexdtetcoa x
name: 4,7,10,13-hexadecatetraenoylcoa
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C37H54N7O17P3S CHARGE: -4
boundary condition: false
has only substance units: false
is: HMDB02288

http://identifiers.org/biomodels.db/MODEL1310110001#_f9f4d01f_e78e_4b32_9c77_2d3d41afdd7e
constant: false
type: Species
initial concentration: NaN
name: BCKDHB
initial amount: NaN
is encoded by: hsa:594
boundary condition: true
is: P21953
has only substance units: false
is: SBO:0000252

metaR r2112
reversible: true
product: MODEL1310110001#
kinetic law: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000185
type: Reaction

metaR DLNLCGCPT2
type: Reaction
product: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine transferase
reversible: false
modifier: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaM cs b deg1 l
has only substance units: false
is: CHEBI:57455
type: Species
is: HMDB01354
notes: FORMULA: C45H67N2O46S3 CHARGE: -5
is: SBO:0000247
initial amount: NaN
boundary condition: false
constant: false
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), degradation product 1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_2ec992ea_7eb3_4604_b9f5_a0bf9e994762
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4129
type: Species
name: MAOB
is: P27338
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN

metaM btn c
initial concentration: 1.0
has only substance units: false
is: HMDB00030
name: Biotin
boundary condition: false
constant: false
initial amount: NaN
is: C00120
type: Species
is: CHEBI:3420
is: SBO:0000247
notes: FORMULA: C10H15N2O3S CHARGE: -1

metaR HMGLm
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (3155.1) or (54511.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.4 Confidence Level: 4 AUTHORS: PMID:11129331 NOTES:TV
type: Reaction
name: hydroxymethylglutaryl-CoA lyase
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.1.3.4
is: SBO:0000176
is described by: ECO:0000134
reversible: false
kinetic law: MODEL1310110001#
fast: false
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_07bb9fa4_9bd3_4df5_9f6f_26e256532fa5
is: P36269
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:2687
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
name: GGT5

metaR EX HC02205 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-b2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_5f3ae15f_a3d3_45aa_baa2_d03315fcaf32
is: O95528
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
name: SLC2A10
initial concentration: NaN
boundary condition: true
is encoded by: hsa:81031
type: Species

metaM urea c
is: SBO:0000247
name: Urea
is: HMDB00294
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
initial amount: NaN
constant: false
has only substance units: false
is: C00086
is: CHEBI:16199
type: Species
boundary condition: false
initial concentration: 1.0

metaR B MANNASEly
name: beta-mannosidase, lysosomal
reversible: false
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.25
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (4126.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.25 Confidence Level: 0 AUTHORS: PMID:9384606 NOTES:NCD
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_b166d644_fffc_4a83_906a_90935b2cf6a6
name: _NOS2A_1_c
type: Species
initial concentration: NaN
is encoded by: hsa:NOS2A
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_aa3725b4_ee46_4eb8_a684_9847ea08d2d9
initial amount: NaN
has only substance units: false
is: Q5FWF5
initial concentration: NaN
name: ESCO1
is: SBO:0000252
is encoded by: hsa:114799
type: Species
constant: false
boundary condition: true

metaR CYTK12
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
name: cytidylate kinase (dCMP,dCTP)
modifier: MODEL1310110001#
fast: false

metaM acgpail hs c
is: SBO:0000247
name: 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol(1-)
is: CHEBI:57265
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C17H29NO14PFULLRCO2FULLR2CO2 CHARGE: -1 EHMN_ABBREVIATION: C01288
type: Species

metaR HIStN1
kinetic law: MODEL1310110001#
is described by: ECO:0000269
type: Reaction
fast: false
reactant: MODEL1310110001#
name: Histidine transport (Na, H coupled)
notes: GENE_ASSOCIATION: (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
modifier: MODEL1310110001#
is: SBO:0000185
reversible: true
product: MODEL1310110001#

metaM CE5162 r
notes: FORMULA: C39H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h11-12,18-19,26-28,32-34,38,49-50H,4-10,13-17,20-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b12-11-,19-18+/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5162
initial amount: NaN
is: CHEBI:57923
is: SBO:0000247
name: trans,cis-2,9-octadecadienoyl-CoA
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_8a99f877_16a9_4fba_9b18_2d0389f657cb
has part: Q9UPY5
boundary condition: true
name: SLC7A11:SLC3A2
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:23657

metaR r2115
is described by: ECO:0000000
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110001#
type: Reaction
reversible: true
is: SBO:0000185
reactant: MODEL1310110001#

metaR FAOXC101m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)m
type: Reaction

metaR ALOX52
kinetic law: MODEL1310110001#
name: Arachidonate 5-lipoxygenase
reversible: false
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (240.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 1.13.11.34 Confidence Level: 4 AUTHORS: PMID:11160764 NOTES:cofactors + usage still not clear unknown mechanism - biochemistry supported by PMID: 2829172, 11160764
fast: false
modifier: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.13.11.34

metaR FAOXC123m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)m
type: Reaction

metaR CYTK11
name: cytidylate kinase (dCMP,dGTP)
fast: false
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
reversible: true
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.14
is described by: ECO:0000269

metaM estrones c
initial concentration: 1.0
name: estrone 3-sulfate(1-)
is: SBO:0000247
has only substance units: false
constant: false
type: Species
is: HMDB01425
notes: FORMULA: C18H21O5S CHARGE: -1 INCHI: InChI=1S/C18H22O5S/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22)/p-1/t14-,15-,16+,18+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00961 EHMN_ABBREVIATION: C02538
is: CHEBI:60050
initial amount: NaN
boundary condition: false

metaR r2114
type: Reaction
reversible: true
kinetic law: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false
product: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110001#
reactant: MODEL1310110001#

metaM acgam1p c
has only substance units: false
boundary condition: false
is: HMDB01367
name: N-Acetyl-D-glucosamine 1-phosphate
constant: false
is: CHEBI:7125
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6-,7-,8?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01256 EHMN_ABBREVIATION: C04256

metaR KYNAKGAT
is: SBO:0000176
notes: GENE_ASSOCIATION: (51166.1) or (883.1) or (51166.2) SUBSYSTEM: Tryptophan metabolism EC Number: 2.6.1.7 Confidence Level: 4 AUTHORS: PMID:15016471 NOTES:SAB
reversible: false
name: L-Kynurenine:2-oxoglutarate aminotransferase
is version of: http://identifiers.org/ec-code/2.6.1.64
kinetic law: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.6.1.7
reactant: MODEL1310110001#
fast: false
is described by: ECO:0000269

metaR HMGCOARc
kinetic law: MODEL1310110001#
name: Hydroxymethylglutaryl CoA reductase (ir) in cytosol
notes: GENE_ASSOCIATION: (3156.1) SUBSYSTEM: Squalene and cholesterol synthesis EC Number: Confidence Level: 4 AUTHORS: Davidson, N. O., Magun, A. M. and Glickman, R. M. 2011. Enterocyte Lipid Absorption and Secretion. Comprehensive Physiology. 505?526, PMID: 17015489, PMID: 18216769, PMID: 6833883, PMID: 11229876. NOTES:Enterocytes stand next to liver in endogenous cholesterol synthesis. in rats they provide 25% of bodys cholesterol. the crypt epithelial cells synthesize maximum cholesterol when compared to other parts of the GI tract (PMCID: PMC292609). enzyme is located in E.R. but has catalytic site facing the cytosol (D.S. Sheriff (2004) Medical biochemistry, 1st edition Jaypee brothers Medical publishers pvt ltd page 502).
reversible: false
is: SBO:0000176
product: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
fast: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.34
is described by: ECO:0000134

metaR TTDCAtr
product: MODEL1310110001#
is: SBO:0000185
reactant: MODEL1310110001#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10811962,PMID:11161786 NOTES:
fast: false
name: tetradecanoate (transport)
is described by: ECO:0000269
kinetic law: MODEL1310110001#

metaR NACHEX25ly
reactant: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3073.1) or (3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110001#
type: Reaction
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110001#_3d2004e7_50fc_4c62_ae5f_94246e84bc0b
is encoded by: hsa:5315
type: Species
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
name: PKM2
initial concentration: NaN

metaR C6COAt
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of of hexanoylcoa for transport into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_97b27dc4_df7f_4e3f_8faa_344190c2b2c7
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: AKR1B1
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:231
is: P15121
type: Species

metaM urea e
type: Species
is: C00086
is: HMDB00294
initial concentration: 1.0
name: Urea
is: SBO:0000247
constant: false
notes: FORMULA: CH4N2O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00089 EHMN_ABBREVIATION: C00086
is: CHEBI:16199
boundary condition: false
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_86c8e603_7e0b_4485_8334_8d39200752cb
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5151
name: PDE8A
has only substance units: false
boundary condition: true
initial concentration: NaN

metaR CYTK10
reversible: true
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110001#
name: cytidylate kinase (CMP,dGTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#
is described by: ECO:0000269
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_3f385961_8d4b_47e9_9219_198aa692c6f5
boundary condition: true
is encoded by: hsa:2348
initial amount: NaN
is: SBO:0000252
name: FOLR1
type: Species
constant: false
initial concentration: NaN
has only substance units: false

metaR SERt4
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958,PMID:11342143,PMID:11414754 NOTES:JLR
reversible: false
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
name: L-serine via sodium symport
type: Reaction
fast: false
product: MODEL1310110001#
is described by: ECO:0000269
is: SBO:0000185

metaR ACITL
fast: false
is described by: ECO:0000000
reversible: false
product: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (47.1) or (47.2) SUBSYSTEM: Citric acid cycle EC Number: 2.3.3.8 Confidence Level: 4 AUTHORS: PMID:2295639 NOTES:ATP dependent citrate lyase. Reaction is reversible in KEGG (new EC 2.3.3.8) NCD
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.3.8
name: ATP-Citrate lyase
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#

metaM Tyr ggn e
notes: FORMULA: XOH CHARGE: 0
constant: false
name: Tyr-194 of apo-glycogenin protein (primer for glycogen synthesis)
is: SBO:0000247
initial amount: NaN
is: HMDB06409
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_c702e30d_d4e1_4af9_b976_d5cda142cd5a
has only substance units: false
initial concentration: NaN
is encoded by: hsa:130752
is: SBO:0000252
type: Species
constant: false
name: MDH1B
initial amount: NaN
is: Q5I0G3
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_3a00c2d5_88ae_4b35_845d_4e089ce73a20
name: AICDA
initial concentration: NaN
is encoded by: hsa:57379
is: Q546Y9
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_7386b797_1011_4fb0_a9ba_7a1946699351
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: P46459
has only substance units: false
constant: false
initial amount: NaN
name: NSF
is encoded by: hsa:4905
type: Species

metaM dgtp e
boundary condition: false
is: CHEBI:16497
name: dGTP
is: HMDB01440
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17)/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
initial concentration: 1.0

metaR CDPDAGtm
is described by: ECO:0000000
product: MODEL1310110001#
reversible: true
fast: false
type: Reaction
name: intracellular transport
is: SBO:0000185
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ

metaR r2117
is described by: ECO:0000000
modifier: MODEL1310110001#
fast: false
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110001#

metaR ILEt5m
is: SBO:0000185
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
name: Isoleucine mitochondrial transport
fast: false
reactant: MODEL1310110001#
type: Reaction

metaR EX HC01104 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-nitrophenyl phosphate(2-)
type: Reaction

metaM HC02205 e
has only substance units: false
boundary condition: false
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
name: prostaglandin-b2
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
is: CHEBI:28099
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_a48c333b_6711_415a_ae82_d35b5990689f
is: B4DX94
name: PGM3
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
is encoded by: hsa:5238
has only substance units: false
is: SBO:0000252
boundary condition: true

metaR EX vitd3 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for calctriol
type: Reaction

metaM 44mctr r
is: CHEBI:17813
name: 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol
boundary condition: false
notes: FORMULA: C29H46O CHARGE: 0 INCHI: InChI=1S/C29H46O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,13,20,22,25-26,30H,8,10-12,14-18H2,1-7H3/t20-,22-,25+,26+,28-,29-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01808 EHMN_ABBREVIATION: C11455
is: HMDB01023
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

metaM h2o2 x
constant: false
type: Species
initial amount: NaN
has only substance units: false
name: Hydrogen peroxide
is: HMDB03125
initial concentration: 1.0
boundary condition: false
is: CHEBI:16240
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: C00027
is: SBO:0000247

metaR TRIODTHYt2
product: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
is: SBO:0000185
name: T3 transport via facilitated diffusion
notes: GENE_ASSOCIATION: (6567.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12871948,PMID:7981683 NOTES:NJ
is described by: ECO:0000269
reversible: true
fast: false
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_c1d7b671_82b7_4783_8f73_4c6c48443976
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
is encoded by: hsa:29925
boundary condition: true
is: SBO:0000252
type: Species
name: GMPPB

http://identifiers.org/biomodels.db/MODEL1310110001#_e08027b1_c2d6_4d67_9997_b9c43e864f47
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:8534
is: O43916
is: SBO:0000252
boundary condition: true
name: CHST1

metaR EX glyc S LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (S)-Glycerate exchange
type: Reaction

metaR CITt4 4
modifier: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000006
reactant: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (284111.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12177002,PMID:12445824 NOTES:NCD
name: citrate transport via sodium symport
fast: false
is: SBO:0000185

metaR SCP21cx
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of phytanoylcoa from cytosol to peroxisomes.
type: Reaction

metaR r2116
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110001#
is described by: ECO:0000000
modifier: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110001#
fast: false

metaM C05965 e
is: SBO:0000247
boundary condition: false
is: HMDB04243
initial concentration: 1.0
is: CHEBI:57444
has only substance units: false
constant: false
type: Species
name: 12(S)-HPETE(1-)
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-4-5-10-13-16-19(24-23)17-14-11-8-6-7-9-12-15-18-20(21)22/h7-11,13-14,17,19,23H,2-6,12,15-16,18H2,1H3,(H,21,22)/p-1/b9-7-,11-8-,13-10-,17-14+/t19-/m0/s1 EHMN_ABBREVIATION: C05965
initial amount: NaN

metaR RE2659R
is: SBO:0000176
reversible: true
name: RE2659
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9647871 NOTES:
reactant: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
type: Reaction
fast: false
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_26728e99_e184_4fd2_90f0_86d6f48e92c6
is: P00441
has only substance units: false
name: SOD1
boundary condition: true
is encoded by: hsa:6647
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

metaM sl L e
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1
name: (S)-3-sulfonatolactate(2-)
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: CHEBI:61289
initial concentration: 1.0

metaR r2119
modifier: MODEL1310110001#
fast: false
is described by: ECO:0000000
reversible: true
product: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is: SBO:0000185

metaM HC01434 m
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C6H3O7 CHARGE: -3 INCHI: InChI=1S/C6H6O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 EHMN_ABBREVIATION: C05379
initial concentration: 1.0
name: oxalatosuccinate(3-)
type: Species
is: CHEBI:58931

metaR EX 3mob LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-methyl-2-oxobutanoate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_b792b7a9_aabe_4202_a841_b86ae9cb3bac
type: Species
is encoded by: hsa:AI761708
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
name: _AI761708_1_m
is: SBO:0000252

metaR r1642
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
reversible: true
is: SBO:0000185
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#

metaM lnlncacrn m
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: alpha-linolenyl carnitine
is: HMDB06319
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
initial amount: NaN
type: Species

metaM pnto R c
name: (R)-Pantothenate
is: HMDB00210
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
type: Species
is: CHEBI:7916
has only substance units: false
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false

metaR HSD11B1r
type: Reaction
is: SBO:0000176
reversible: true
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: 11-beta-hydroxysteroid dehydrogenase type 1
is version of: http://identifiers.org/ec-code/1.1.1.146
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (3290.2) or (3290.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.146 Confidence Level: 4 AUTHORS: PMID:11673786,PMID:15466942,PMID:7859916 NOTES:NJ
reactant: MODEL1310110001#
fast: false
modifier: MODEL1310110001#

metaR DNDPt46m
product: MODEL1310110001#
is: SBO:0000185
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110001#
modifier: MODEL1310110001#
name: dTTP transport via dUDP antiport
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
kinetic law: MODEL1310110001#

metaR ADPT
reactant: MODEL1310110001#
name: adenine phosphoribosyltransferase
kinetic law: MODEL1310110001#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (353.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.7 Confidence Level: 4 AUTHORS: PMID:14674717,PMID:15196008 NOTES:
type: Reaction
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.2.7
is described by: ECO:0000269
modifier: MODEL1310110001#
fast: false

metaR EX HC00229 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Isomaltose
type: Reaction

metaR r2118
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reversible: true
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_7cb05507_bc53_44c4_944e_3295084bc380
initial concentration: NaN
name: ADO
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: B3KXN9
is encoded by: hsa:84890

metaM btn m
constant: false
type: Species
notes: FORMULA: C10H15N2O3S CHARGE: -1 INCHI: InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/p-1/t6-,7-,9-/m0/s1 EHMN_ABBREVIATION: C00120
name: biotinate
boundary condition: false
is: SBO:0000247
is: CHEBI:57586
initial concentration: 1.0
is: HMDB00030
has only substance units: false
initial amount: NaN

metaR HSD3B11
notes: GENE_ASSOCIATION: (3283.1) SUBSYSTEM: Steroid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:16023337 NOTES:progesterone prduction measured after the incubation of human granulosa cells with pregnenolone
is: SBO:0000176
reactant: MODEL1310110001#
reversible: false
fast: false
modifier: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000134
name: 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I
is version of: http://identifiers.org/ec-code/1.1.1.145

metaR r1641
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_3ae7012f_c68d_434f_961b_f3a654b135aa
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:D87002
name: _D87002_1_m
constant: false
is: SBO:0000252
boundary condition: true

metaM HC02205 c
type: Species
name: prostaglandin-b2
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H29O4 CHARGE: -1 INCHI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1 EHMN_ABBREVIATION: C05954
is: SBO:0000247
initial concentration: 1.0
constant: false
is: CHEBI:28099
boundary condition: false

metaM CE5119 m
type: Species
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,13-14,22-24,28-30,34,45-46H,4-7,10-12,15-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,14-13+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5119
is: CHEBI:57923
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN
boundary condition: false
name: trans-3-cis-8-tetradecadienoyl-CoA

metaM h2o2 n
boundary condition: false
is: CHEBI:16240
is: HMDB03125
constant: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
initial concentration: 1.0
initial amount: NaN
type: Species
name: hydrogen peroxide

http://identifiers.org/biomodels.db/MODEL1310110001#_2bc01e3e_156f_44d2_af3f_59daa44c5bf1
is encoded by: hsa:9334
has only substance units: false
name: B4GALT5
type: Species
is: O43286
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_dd27bb85_9cc8_4762_b048_700a0c849fb8
type: Species
is: Q6IBC0
is: SBO:0000252
is encoded by: hsa:3155
boundary condition: true
name: HMGCL
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false

metaR SUCCOAPET
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of succinyl coa for release into cytosol
type: Reaction

metaR 2OXOADPTm
product: MODEL1310110001#
is: SBO:0000185
reactant: MODEL1310110001#
modifier: MODEL1310110001#
reversible: true
fast: false
name: 2-oxoadipate shuttle (cytosol/mitochondria)
type: Reaction
kinetic law: MODEL1310110001#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (89874.1) SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11083877 NOTES:SAB PMID 11083877

metaR RE1342C
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
fast: false
name: RE1342
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 0 AUTHORS: PMID:9537432 NOTES:IT - fixed proton

metaR r1640
is described by: ECO:0000000
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110001#
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM pnto R e
is: HMDB00210
name: (R)-Pantothenate
is: CHEBI:7916
type: Species
notes: FORMULA: C9H16NO5 CHARGE: -1 INCHI: InChI=1S/C9H17NO5/c1-9(2,5-11)7(14)8(15)10-4-3-6(12)13/h7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13) HEPATONET_1.0_ABBREVIATION: HC00568
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR GTHOm
is version of: http://identifiers.org/ec-code/1.8.1.7
reversible: false
fast: false
name: glutathione oxidoreductase
is described by: ECO:0000254
type: Reaction
product: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558,PMID:15149466 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2

metaM ptdcacrn m
constant: false
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
has only substance units: false
is: HMDB01721
is: CHEBI:15811
type: Species
initial amount: NaN
name: pendtadenoyl carnitine
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaR r0892
fast: false
product: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:179827,PMID:9305892 NOTES:
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.1.2.27
reactant: MODEL1310110001#
type: Reaction
reversible: true
name: Facilitated diffusion
is described by: ECO:0000000
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_d106eea0_c924_430d_9f46_a6ad515e50d3
boundary condition: true
has only substance units: false
type: Species
name: AKR1C4
initial amount: NaN
is: P17516
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:1109
constant: false

metaM h2o2 m
type: Species
initial amount: NaN
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
is: HMDB03125
name: Hydrogen peroxide
initial concentration: 1.0
is: CHEBI:16240
is: C00027
has only substance units: false
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_de43dcd3_e40e_4ce2_b556_3f72adced00f
is: O00443
type: Species
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: PIK3C2A
is encoded by: hsa:5286

metaM 4hpro LT c
name: trans-4-hydroxy-L-proline
is: CHEBI:18095
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00690
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00725

metaR O2ter
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
name: O2 transport, endoplasmic reticulum
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110001#
fast: false
type: Reaction

metaM acgam c
is: SBO:0000247
constant: false
name: N-acetyl-D-glucosamine
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6+,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00138 EHMN_ABBREVIATION: C00140
is: CHEBI:17411
boundary condition: false
type: Species
has only substance units: false
is: HMDB00215
initial amount: NaN
initial concentration: 1.0

metaR r1429
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
fast: false
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
name: Free diffusion
is described by: ECO:0000000
type: Reaction
reversible: true

metaR r0437
is: SBO:0000176
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.1.2.13
modifier: MODEL1310110001#
reversible: true
type: Reaction
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (AI469183.1) or (226.1) or (229.1) or (230.1) or (BC005314.1) or (BF195998.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false

metaM nac c
boundary condition: false
is: SBO:0000247
is: CHEBI:0
initial concentration: 1.0
is: HMDB01488
initial amount: NaN
name: Nicotinate
is: C00253
has only substance units: false
type: Species
constant: false
notes: FORMULA: C6H4NO2 CHARGE: -1

metaR FAS160COA
is: SBO:0000176
fast: false
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
reactant: MODEL1310110001#
modifier: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reversible: false
name: fatty-acyl-CoA synthase (n-C16:0CoA)

http://identifiers.org/biomodels.db/MODEL1310110001#_8fb27b7f_3a16_44cb_8095_42769840c711
type: Species
has only substance units: false
is encoded by: hsa:2109
has part: P38117
initial concentration: NaN
constant: false
is: SBO:0000297
boundary condition: true
name: ETFA:ETFB
initial amount: NaN

metaM ksii core4 pre5 g
initial concentration: 1.0
is: HMDB00175
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 5
initial amount: NaN
notes: FORMULA: C69H112N6O48X CHARGE: -1
type: Species
is: SBO:0000247
constant: false
is: CHEBI:58053
has only substance units: false
is: C00130

metaR GALASE13ly
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
reactant: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.6.4
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_1c51fcaf_4345_4ced_8205_1272f1992b09
initial amount: NaN
is encoded by: hsa:LOC728997
name: _LOC728997_1_c
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_215ee895_035e_47ca_8b50_eaf14090e5fa
type: Species
is: O95498
constant: false
has only substance units: false
boundary condition: true
name: VNN2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:8875

metaR FAOXC102C101x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:1)x
type: Reaction

metaR LCADi
fast: false
is: SBO:0000176
reactant: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.2.1.3
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
notes: GENE_ASSOCIATION: (218.1) or (223.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (501.1) or (220.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.2.1.21 Confidence Level: 2 AUTHORS: PMID:15987839,PMID:2296157,PMID:6487654 NOTES:JLR- added irreversible form of LCAD
is version of: http://identifiers.org/ec-code/1.2.1.36
kinetic law: MODEL1310110001#
name: lactaldehyde dehydrogenase
reversible: false
modifier: MODEL1310110001#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110001#_ab093ef7_47b1_4827_a916_6775e0476447
boundary condition: true
initial amount: NaN
name: SDHD
has only substance units: false
is encoded by: hsa:6392
type: Species
is: SBO:0000252
constant: false
is: O14521
initial concentration: NaN

metaR r1428
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:17045662 NOTES:
name: Free diffusion
is described by: ECO:0000000
reactant: MODEL1310110001#
type: Reaction
reversible: true
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
fast: false

metaM retinal c
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
is: CHEBI:15035
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3 EHMN_ABBREVIATION: C00376
constant: false
is: HMDB01358
has only substance units: false
initial concentration: 1.0
name: retinal

metaM lald D c
initial concentration: 1.0
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h2-3,5H,1H3/t3-/m1/s1
type: Species
is: SBO:0000247
constant: false
name: (R)-lactaldehyde
is: HMDB06458
has only substance units: false
is: CHEBI:17167
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_4657705b_93eb_43da_91f8_f879e3a8f446
name: NT5M
constant: false
initial concentration: NaN
is: Q9NPB1
has only substance units: false
type: Species
is: SBO:0000252
boundary condition: true
is encoded by: hsa:56953
initial amount: NaN

metaM gullac r
initial concentration: 1.0
has only substance units: false
is: HMDB03466
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: L-gulono-1,4-lactone
constant: false
type: Species
is: CHEBI:17587

metaM glac r
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
boundary condition: false
initial concentration: 1.0
is: CHEBI:18268
is: HMDB06355
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
name: D-glucurono-6,3-lactone
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_f20f23e6_fdd2_4f83_a351_a98d118eae7b
constant: false
is encoded by: hsa:123041
initial amount: NaN
name: SLC24A4
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
boundary condition: true

metaR 3MOBte
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000134
reactant: MODEL1310110001#
reversible: true
name: Transport of 3-methyl-2-oxobutanoate
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_34951d54_c630_488c_b348_7eb20cff1ed6
constant: false
is encoded by: hsa:38
boundary condition: true
is: P24752
type: Species
initial concentration: NaN
name: ACAT1
has only substance units: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_a45de316_5282_4e2a_afe8_e317b5ff699a
boundary condition: true
initial concentration: NaN
is encoded by: hsa:53354
has only substance units: false
constant: false
is: SBO:0000252
name: PANK1
type: Species
initial amount: NaN

metaM nac e
is: SBO:0000247
notes: FORMULA: C6H4NO2 CHARGE: -1
initial amount: NaN
boundary condition: false
is: HMDB01488
initial concentration: 1.0
type: Species
is: C00253
constant: false
has only substance units: false
is: CHEBI:0
name: Nicotinate

metaM 4hpro LT e
is: HMDB00725
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
type: Species
notes: FORMULA: C5H9NO3 CHARGE: 0 INCHI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
initial amount: NaN
boundary condition: false
name: trans-4-hydroxy-L-proline

metaM duri e
name: Deoxyuridine
is: C00526
is: CHEBI:16450
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: HMDB00012
has only substance units: false
constant: false
type: Species
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_200c3298_4e9b_41c0_92fb_34791f1b03c2
boundary condition: true
has part: O00330
initial concentration: NaN
has part: P09622
is encoded by: hsa:4967
is: SBO:0000297
name: DLD:DLST:OGDH:PDHX
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:1743
has part: P36957
is encoded by: hsa:1738
has part: Q02218
is encoded by: hsa:8050

metaM 3hddcoa c
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
boundary condition: false
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: HMDB00623
name: (S)-3-Hydroxydodecanoyl-CoA
constant: false
has only substance units: false

metaR r0434
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (AI824319.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:
fast: false
is: SBO:0000176

metaR FAOXC163C143m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:3-->C14:3)m
type: Reaction

metaM sl L c
is: CHEBI:61289
name: (S)-3-sulfonatolactate(2-)
is: SBO:0000247
notes: FORMULA: C3H4O6S CHARGE: -2 INCHI: InChI=1S/C3H6O6S/c4-2(3(5)6)1-10(7,8)9/h2,4H,1H2,(H,5,6)(H,7,8,9)/p-2/t2-/m1/s1
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false

metaR PSERT
reactant: MODEL1310110001#
is described by: ECO:0000269
product: MODEL1310110001#
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.52
notes: GENE_ASSOCIATION: (29968.1) or (29968.2) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.52 Confidence Level: 4 AUTHORS: PMID:12633500 NOTES:
name: phosphoserine transaminase
is: SBO:0000176
reversible: false
fast: false

metaR G14T11g
product: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
reactant: MODEL1310110001#
reversible: false
kinetic law: MODEL1310110001#
fast: false
is: SBO:0000176
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
is version of: http://identifiers.org/ec-code/2.4.1.90
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD

metaR GLCNACASE2ly
is: SBO:0000176
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.50
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110001#
reactant: MODEL1310110001#
reversible: false
fast: false
modifier: MODEL1310110001#
type: Reaction
name: alpha-N-acetylglucosaminidase, lysosomal

metaR GALASE16ly
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.18
reactant: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.6.4
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: beta-galactosidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110001#_f0420bef_2568_49e5_ae9c_19e1c30d92b5
is encoded by: hsa:6560
name: SLC12A4
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252
is: F5H066
boundary condition: true

metaR FAOXC165C164m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C16:5-->C16:4)m
type: Reaction

metaR FACOAL1832
is: SBO:0000176
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110001#
name: fatty-acid--CoA ligase
product: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ, RE3114C
type: Reaction
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_e5f00533_fcde_47c5_bc3f_2b4dcaf31db0
is: GO:0005764
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: lysosome
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110001#_b558204d_e249_4ae8_816b_960458d7513e
is: SBO:0000252
type: Species
name: MGST2
initial concentration: NaN
is: D6RBB5
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:4258
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_6020f3d7_1491_4936_8a15_bb06e2d5357a
name: PAICS
type: Species
is: SBO:0000252
boundary condition: true
is: P22234
is encoded by: hsa:10606
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaM duri c
name: Deoxyuridine
initial concentration: 1.0
has only substance units: false
is: C00526
is: SBO:0000247
is: CHEBI:16450
initial amount: NaN
is: HMDB00012
notes: FORMULA: C9H12N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00410 EHMN_ABBREVIATION: C00526
type: Species
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_a78b1f87_5296_42dc_a1e5_ab66a11d1a60
is: Q16706
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:4124
has only substance units: false
name: MAN2A1
type: Species
initial concentration: NaN

metaR EX 3octdece1crn
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-octadecenoyl carnitine
type: Reaction

metaM 2dr1p c
is: SBO:0000247
is: C00672
is: HMDB01351
is: CHEBI:58576
boundary condition: false
type: Species
name: 2-Deoxy-D-ribose 1-phosphate
notes: FORMULA: C5H9O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00489 EHMN_ABBREVIATION: C00672
initial amount: NaN
has only substance units: false
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_a962e3f2_482f_4879_9f02_ec4af13d57cb
is encoded by: hsa:217
name: ALDH2
initial concentration: NaN
has only substance units: false
constant: false
type: Species
boundary condition: true
is: SBO:0000252
is: P05091
initial amount: NaN

metaM HC01403 m
initial concentration: 1.0
notes: FORMULA: C31H50N7O18P3S CHARGE: -4 INCHI: InChI=1S/C31H54N7O18P3S/c1-4-5-6-7-8-9-19(39)14-22(41)60-13-12-33-21(40)10-11-34-29(44)26(43)31(2,3)16-53-59(50,51)56-58(48,49)52-15-20-25(55-57(45,46)47)24(42)30(54-20)38-18-37-23-27(32)35-17-36-28(23)38/h17-20,24-26,30,39,42-43H,4-16H2,1-3H3,(H,33,40)(H,34,44)(H,48,49)(H,50,51)(H2,32,35,36)(H2,45,46,47)/t19-,20+,24+,25+,26-,30+/m0/s1 EHMN_ABBREVIATION: C05264
boundary condition: false
is: CHEBI:28325
constant: false
initial amount: NaN
name: (S)-Hydroxydecanoyl-CoA
type: Species
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_fbed220a_451e_46e2_b29a_9b82c3208be0
type: Species
is encoded by: hsa:8277
initial amount: NaN
name: TKTL1
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: B7Z7I0

metaR FACOAL1831
modifier: MODEL1310110001#
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
type: Reaction
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is: SBO:0000176
product: MODEL1310110001#

metaR EX bilirub LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bilirubin exchange
type: Reaction

metaR IVCRNe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of isovaleryl carnitine into the extra cellular space
type: Reaction

metaR DM pe hs LPAREN r RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: PMID: 17173541 NOTES:added during gap-filling, no evidence for such a reaction. only assumed.
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: demand reaction for pe_hs[r]
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_a1394877_e929_432e_8157_2a8ec987e519
name: _HG2846_HT2983_1_c
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:HG2846-HT2983
boundary condition: true
initial concentration: NaN
type: Species
constant: false

metaR C8DCc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberylcarnitine
type: Reaction

metaR M1316Mg
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.114
reversible: false
notes: GENE_ASSOCIATION: (4124.1) or (4122.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.114 Confidence Level: 0 AUTHORS: PMID:8524845 NOTES:NCD
type: Reaction
fast: false
reactant: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
is described by: ECO:0000000
modifier: MODEL1310110001#
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

metaM 4aphdob c
name: 4-(2-aminophenyl)-2,4-dioxobutanoate
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:58147
constant: false
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H8NO4 CHARGE: -1 INCHI: InChI=1S/C10H9NO4/c11-7-4-2-1-3-6(7)8(12)5-9(13)10(14)15/h1-4H,5,11H2,(H,14,15)/p-1 EHMN_ABBREVIATION: C01252
is: HMDB00978

metaR COAtn
product: MODEL1310110001#
is: SBO:0000185
fast: false
reversible: true
name: coenzyme A transport, nuclear
is described by: ECO:0000000
kinetic law: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

metaM lnlncacrn c
is: SBO:0000247
type: Species
name: alpha-linolenyl carnitine
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h6-7,9-10,12-13,23H,5,8,11,14-22H2,1-4H3/b7-6-,10-9-,13-12-/t23-/m0/s1
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false
is: HMDB06319
initial amount: NaN

metaM h2o2 e
is: CHEBI:16240
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB03125
notes: FORMULA: H2O2 CHARGE: 0 INCHI: InChI=1S/H2O2/c1-2/h1-2H HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
name: hydrogen peroxide
has only substance units: false
constant: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_a9e61c73_18d5_4a5b_97f0_66677eb962f4
initial amount: NaN
type: Species
is encoded by: hsa:285973
initial concentration: NaN
name: ATG9B
is: Q674R7
constant: false
boundary condition: true
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_9f8020bc_4125_4723_9189_a503c4012753
has part: Q9H3S5
is encoded by: hsa:93183
initial amount: NaN
is encoded by: hsa:54965
name: PIGX:PIGM
has part: Q8TBF5
initial concentration: NaN
constant: false
is: SBO:0000297
has only substance units: false
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_f86c0744_0745_47ab_9b5e_84f239d853ac
constant: false
is encoded by: hsa:5293
type: Species
has only substance units: false
name: PIK3CD
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: A7E2E0

metaR r1649
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110001#
type: Reaction
reversible: true
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110001#

metaR r1423
fast: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
reversible: false
reactant: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
name: Facilitated diffusion

metaM succoa x
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C25H35N7O19P3S CHARGE: -5
name: Succinyl-CoA
type: Species
constant: false
is: HMDB01022
initial concentration: 1.0

metaR RE3301C
reactant: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 0 AUTHORS: PMID:11182251 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.1.4.4
reversible: true
kinetic law: MODEL1310110001#
name: RE3301
product: MODEL1310110001#
is described by: ECO:0000000
modifier: MODEL1310110001#
type: Reaction

metaR EX dopasf LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Dopamine 3-O-sulfate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_4272a0b3_2c78_403a_a713_17f58180ba07
initial amount: NaN
initial concentration: NaN
name: _2509_1_e
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:2509
is: SBO:0000252
constant: false

metaM ksi deg30 l
initial amount: NaN
type: Species
notes: FORMULA: C90H147N6O75S3 CHARGE: -3
is: SBO:0000247
boundary condition: false
is: HMDB00143
initial concentration: 1.0
constant: false
name: keratan sulfate I, degradation product 30
has only substance units: false
is: CHEBI:12936

metaM ttdca e
is: HMDB00806
has only substance units: false
notes: FORMULA: C14H27O2 CHARGE: -1 EHMN_ABBREVIATION: C06424
constant: false
type: Species
name: tetradecanoate (n-C14:0)
is: SBO:0000247
is: CHEBI:30807
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C06424

http://identifiers.org/biomodels.db/MODEL1310110001#_b4bfc383_bbe5_4405_ad2d_d0adcb1cd50a
is: SBO:0000252
name: SHMT2
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: B4DJQ3
is encoded by: hsa:6472

metaR DMNONCRNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
reversible: true
product: MODEL1310110001#
name: 4,8 dimethylnonanoyl carnitine transport (mitochondria)
is described by: ECO:0000000
kinetic law: MODEL1310110001#
is: SBO:0000185
fast: false
reactant: MODEL1310110001#
type: Reaction

metaM apoC Lys m
is: HMDB00182
boundary condition: false
type: Species
notes: FORMULA: C6H13N2OX CHARGE: 0
is: SBO:0000247
constant: false
is: CHEBI:32551
has only substance units: false
name: Apocarboxylase (Lys residue)
initial concentration: 1.0
initial amount: NaN

metaM hs deg15 l
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:16126
initial amount: NaN
type: Species
notes: FORMULA: C49H71N2O57S5 CHARGE: -7
has only substance units: false
name: heparan sulfate, degradation product 15

metaR COAtm
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
modifier: MODEL1310110001#
reversible: true
is described by: ECO:0000269
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (8034.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TV May not a "real" transporter, use in heart mitochondria model only
type: Reaction
is: SBO:0000185
fast: false
name: CoA transporter

http://identifiers.org/biomodels.db/MODEL1310110001#_7cacfb93_b1e5_4001_aa1b_e0dbe00b1f4f
is encoded by: hsa:125206
constant: false
type: Species
is: A0PJK1
initial concentration: NaN
name: SLC5A10
has only substance units: false
initial amount: NaN
is: SBO:0000252
boundary condition: true

metaR DADA
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.4
reactant: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:JLR
kinetic law: MODEL1310110001#
is described by: ECO:0000269
name: Deoxyadenosine deaminase
product: MODEL1310110001#
fast: false
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_a427af83_ab36_42c5_a497_92b6ce236898
is: P49748
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: ACADVL
type: Species
boundary condition: true
constant: false
is encoded by: hsa:37
has only substance units: false

metaR EX 34hpp
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 3-(4-hydroxyphenyl)pyruvate
type: Reaction

metaR LGTHL
reversible: false
notes: GENE_ASSOCIATION: (2739.1) SUBSYSTEM: Pyruvate metabolism EC Number: 4.4.1.5 Confidence Level: 4 AUTHORS: PMID:7684374,PMID:8449929 NOTES:IF
product: MODEL1310110001#
name: lactoylglutathione lyase
kinetic law: MODEL1310110001#
is described by: ECO:0000269
reactant: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/4.4.1.5
modifier: MODEL1310110001#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_d82912d9_574b_477d_991b_9122f0cc38ab
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
name: PDE6G
boundary condition: true
constant: false
is: P18545
has only substance units: false
is encoded by: hsa:5148

http://identifiers.org/biomodels.db/MODEL1310110001#_85846c65_aebb_442e_a298_8667d75a6cff
initial amount: NaN
has only substance units: false
is: SBO:0000252
name: DEGS1
constant: false
type: Species
is encoded by: hsa:8560
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_3477113b_3eee_43ad_9a1a_cdac0b544b02
initial concentration: NaN
constant: false
is: Q9BTY2
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2519
boundary condition: true
type: Species
name: FUCA2
initial amount: NaN

metaR CAATPS
notes: GENE_ASSOCIATION: (492.1) or (491.1) or (490.1) or (493.1) SUBSYSTEM: Transport, extracellular EC Number: 3.6.3.6 Confidence Level: 4 AUTHORS: PMID:7876199,PMID:8396145 NOTES:plasma membrane version (SR and ER versions also exist) stoichiometry actually varies (number of Ca/ATP transported). See PMID: 7876199 NJ
type: Reaction
reactant: MODEL1310110001#
is described by: ECO:0000269
name: Ca ATPase
is: SBO:0000185
fast: false
reversible: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.6.3.8

metaM cs e deg2 l
is: CHEBI:57455
initial concentration: 1.0
boundary condition: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 2
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
is: HMDB01354
constant: false
has only substance units: false

metaM 2dp6mobq m
notes: FORMULA: C57H86O3 CHARGE: 0 INCHI: InChI=1S/C57H86O3/c1-44(2)22-13-23-45(3)24-14-25-46(4)26-15-27-47(5)28-16-29-48(6)30-17-31-49(7)32-18-33-50(8)34-19-35-51(9)36-20-37-52(10)38-21-39-53(11)40-41-54-42-55(58)43-56(60-12)57(54)59/h22,24,26,28,30,32,34,36,38,40,42-43H,13-21,23,25,27,29,31,33,35,37,39,41H2,1-12H3/b45-24+,46-26+,47-28+,48-30+,49-32+,50-34+,51-36+,52-38+,53-40+
has only substance units: false
is: CHEBI:50773
constant: false
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone
boundary condition: false
is: SBO:0000247
type: Species
initial amount: NaN
initial concentration: 1.0

metaM h2o2 c
name: Hydrogen peroxide
is: HMDB03125
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: C00027
constant: false
notes: FORMULA: H2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00036 EHMN_ABBREVIATION: C00027
type: Species
is: CHEBI:16240
has only substance units: false
is: SBO:0000247

metaR FAOXC101x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C10:1)x
type: Reaction

metaR r0899
name: Amino acid transporter ATB0+ Facilitated diffusion
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10721894,PMID:11787643,PMID:12269802,PMID:12504794,PMID:16955229,PMID:17401668,PMID:18599538,PMID:3132542,PMID:487087,PMID:551321,PMID:6418146,PMID:7731061,PMID:8010975,PMID:8382624,PMID:8654117,PMID:8899554,PMID:911815,PMID:917262 NOTES:
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000185
kinetic law: MODEL1310110001#
fast: false
is described by: ECO:0000000
reversible: true

metaR GALT
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.7.12
is: SBO:0000176
fast: false
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
name: galactose-1-phosphate uridylyltransferase
product: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:1427861 NOTES:
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_9e0263f1_a893_46ab_aab7_bc53cabe203f
initial amount: NaN
constant: false
is encoded by: hsa:8527
initial concentration: NaN
is: SBO:0000252
type: Species
name: DGKD
boundary condition: true
has only substance units: false

metaR r1647
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
type: Reaction
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_c4f8e9f2_e092_477b_9a91_ee7b257f94c9
is: O00764
type: Species
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:8566
is: SBO:0000252
initial amount: NaN
name: PDXK
has only substance units: false

metaR C14OHc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxytetradecanoylcarnitine
type: Reaction

metaR COAtl
name: CoA transport in lysosome via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:6313022 NOTES:IT
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110001#

metaM strdnccrn c
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB06463
notes: FORMULA: C25H41NO4 CHARGE: 0 INCHI: InChI=1/C25H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h6-7,9-10,13-14,17-18,23H,5,8,11-12,15-16,19-22H2,1-4H3/b7-6-,10-9-,14-13-,18-17-
boundary condition: false
name: stearidonyl carnitine

http://identifiers.org/biomodels.db/MODEL1310110001#_7bc6ec3e_2ec1_4964_bd67_4acabe1d7523
constant: false
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: A8K8P8
has only substance units: false
is encoded by: hsa:2530
name: FUT8
boundary condition: true
type: Species

metaR S2TASE2ly
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: false
notes: GENE_ASSOCIATION: (3423.1) or (3423.2) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.13 Confidence Level: 4 AUTHORS: PMID:2122463,PMID:8244397,PMID:8530090,PMID:8993162 NOTES:NCD
product: MODEL1310110001#
is described by: ECO:0000000
modifier: MODEL1310110001#
name: iduronate-2-sulfatase, lysosomal
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.13
type: Reaction
fast: false

metaR EX HC01610 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of CoproporphyrinogenI
type: Reaction

metaM ksi deg17 l
notes: FORMULA: C152H245N10O132S7 CHARGE: -7
constant: false
is: SBO:0000247
initial amount: NaN
is: HMDB00143
boundary condition: false
is: CHEBI:12936
type: Species
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 17

metaR GLYCTDle
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: difussion of glycerol accross the brush border membrane
reactant: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000134
kinetic law: MODEL1310110001#
is: SBO:0000185
reversible: true

metaR GALU
notes: GENE_ASSOCIATION: (7360.1) or (7359.1) or (7360.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.9 Confidence Level: 0 AUTHORS: PMID:9119383 NOTES:Human Y/N: Y
name: UTP-glucose-1-phosphate uridylyltransferase
reactant: MODEL1310110001#
fast: false
is described by: ECO:0000134
reversible: true
type: Reaction
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.7.9
is: SBO:0000176
product: MODEL1310110001#
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_195895a8_b2d2_4552_ac26_f85198effbe3
initial concentration: NaN
type: Species
name: GUCY2F
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is: P51841
is encoded by: hsa:2986
initial amount: NaN

metaM gullac c
boundary condition: false
notes: FORMULA: C6H10O6 CHARGE: 0 INCHI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2/t2-,3+,4-,5+/m0/s1
initial concentration: 1.0
is: HMDB03466
is: CHEBI:17587
initial amount: NaN
constant: false
has only substance units: false
name: L-gulono-1,4-lactone
is: SBO:0000247
type: Species

metaR r1648
modifier: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: true
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#

metaR ACOAD10m
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
is described by: ECO:0000269
product: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (36.1) or (34.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.3.99.12 Confidence Level: 4 AUTHORS: PMID:11013134 NOTES:MM
reversible: false

metaM c12dc c
initial amount: NaN
boundary condition: false
notes: FORMULA: C19H34NO6 CHARGE: -1
type: Species
is: SBO:0000247
name: dodecanedioyl carnitine
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB00623

http://identifiers.org/biomodels.db/MODEL1310110001#_3ff4e1f1_6e27_4f96_8c4e_dd5257f1d6c7
initial concentration: NaN
type: Species
is encoded by: hsa:91373
name: UAP1L1
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
is: Q3KQV9
is: SBO:0000252

metaR SPHMYLNtg
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: PMID:15907394 NOTES:unknown mechanism for transport - however must get to other intracellular compartments (e.g. lysosome for degradation) NJ
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
name: sphingomyelin intracellular transport
is: SBO:0000185
type: Reaction
product: MODEL1310110001#
fast: false
is described by: ECO:0000000

metaM ocdca c
initial amount: NaN
is: CHEBI:25629
has only substance units: false
boundary condition: false
is: SBO:0000247
name: stearate
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C18H35O2 CHARGE: -1 INCHI: InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)/p-1 EHMN_ABBREVIATION: C01530
is: HMDB00827

metaR AMPDA
type: Reaction
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.6 Confidence Level: 4 AUTHORS: PMID:1400401,PMID:2345176 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.6
reactant: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
is described by: ECO:0000269
modifier: MODEL1310110001#
reversible: false
name: Adenosine monophosphate deaminase
product: MODEL1310110001#

metaR r0268
is: SBO:0000176
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.3.2
modifier: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: (52.1) or (53.1) or (54.1) or (51205.1) or (55.1) or (AI191472.1) or (248.1) or (249.1) or (250.1) or (251.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:10052592,PMID:1964451,PMID:2249689 NOTES:
reactant: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.3.1
name: cytidine monophospho-N-acetylneuraminic acid hydroxylase EC:1.14.18.2
fast: false

metaR r1645
is described by: ECO:0000000
product: MODEL1310110001#
is: SBO:0000185
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#
reversible: true

metaM xyl D l
name: aldehydo-D-xylose
type: Species
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h1,3-5,7-10H,2H2/t3-,4+,5+/m0/s1
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:15936
boundary condition: false
is: SBO:0000247

metaM 2docopencoa x
boundary condition: false
name: 2,7,10,13,16-docosapentenoylcoa
is: SBO:0000247
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/24892790
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_ff45d24f_b82c_48d9_822e_2eddec13a017
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:5019
is: SBO:0000252
constant: false
is: P55809
has only substance units: false
name: OXCT1

metaR COAtr
reversible: true
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
name: COA transporter, endoplasmic reticulum
is: SBO:0000185
product: MODEL1310110001#

metaR GALASE20ly
is described by: ECO:0000000
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
reactant: MODEL1310110001#
modifier: MODEL1310110001#
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.4.16.5
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_a02cfb6d_692f_46e3_8b6f_4b568a2815b9
initial amount: NaN
is: P51648
has only substance units: false
name: ALDH3A2
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:224
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_cae0ff56_edec_4a3a_9bc1_7a1156004b20
is: Q16774
has only substance units: false
boundary condition: true
is encoded by: hsa:2987
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: GUK1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_6d98ad49_a8c4_49fd_b8d4_6502a552233e
initial amount: NaN
type: Species
name: KDSR
boundary condition: true
is: Q06136
is encoded by: hsa:2531
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252

metaM dcacoa c
is: C05274
is: HMDB06404
has only substance units: false
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
initial amount: NaN
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
name: Decanoyl-CoA (n-C10:0CoA)
is: CHEBI:61430
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_71c96e6b_62af_499b_9f58_1dd9d1980d58
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:6536
has only substance units: false
name: SLC6A9
is: B7Z3W8
type: Species
boundary condition: true
is: SBO:0000252

metaR r0267
name: CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating) Aminosugars metabolism EC:1.14.18.2
is version of: http://identifiers.org/ec-code/3.5.1.9
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (125061.1) SUBSYSTEM: Unassigned EC Number: 1.14.18.2 Confidence Level: 0 AUTHORS: PMID:11211935,PMID:2249689,PMID:8112313 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
is: SBO:0000176

metaR G14T4g
type: Reaction
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176
reversible: false
modifier: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110001#

metaR EX c51crn
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tiglyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_f0b14492_0cc6_405e_a0d9_a691fbfe4524
type: Species
name: COX7A1
initial amount: NaN
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:1346
is: P24310
is: SBO:0000252
has only substance units: false

metaR r1646
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110001#
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR COQ6m
modifier: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (51004.1) or (51004.2) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_1.13.12.- IT
type: Reaction
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000269
fast: false
reversible: false
name: Ubiquinone biosynthesis monooxgenase COQ6

metaM 6pgl r
has only substance units: false
is: HMDB01127
initial amount: NaN
is: CHEBI:57955
is: SBO:0000247
constant: false
name: 6-O-phosphonato-D-glucono-1,5-lactone(2-)
boundary condition: false
notes: FORMULA: C6H9O9P CHARGE: -2 INCHI: InChI=1S/C6H11O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-5,7-9H,1H2,(H2,11,12,13)/p-2/t2-,3-,4+,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00733 EHMN_ABBREVIATION: C01236
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_54a94f0b_de0e_4d56_9059_94d9e9ed760c
has only substance units: false
constant: false
is: P20933
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
name: AGA
boundary condition: true
is encoded by: hsa:175

metaR 4ABUTtcn
kinetic law: MODEL1310110001#
reversible: false
fast: false
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000185
name: transport of GABA
is described by: ECO:0000134
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: Jane D. Carver, W. Allan Walkera , The Journal of Nutritional Biochemistry, Volume 6, Issue 2, February 1995, Pages 58?72. NOTES:added during gap-filling, required for GABA role in cell proliferation.

metaM mmcoa R m
is: CHEBI:57326
notes: FORMULA: C25H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C25H40N7O19P3S/c1-12(23(37)38)24(39)55-7-6-27-14(33)4-5-28-21(36)18(35)25(2,3)9-48-54(45,46)51-53(43,44)47-8-13-17(50-52(40,41)42)16(34)22(49-13)32-11-31-15-19(26)29-10-30-20(15)32/h10-13,16-18,22,34-35H,4-9H2,1-3H3,(H,27,33)(H,28,36)(H,37,38)(H,43,44)(H,45,46)(H2,26,29,30)(H2,40,41,42)/p-5/t12-,13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00721
name: (R)-methylmalonyl-CoA(5-)
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
is: HMDB01269
type: Species
is: SBO:0000247
initial amount: NaN

metaR RE1525M
product: MODEL1310110001#
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110001#
name: RE1525
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
modifier: MODEL1310110001#

metaM m1mpdol U c
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C1305H2140N20O270P20 CHARGE: -20 INCHI: InChI=1S/C53H92N2O27P2/c1-27(2)13-9-14-28(3)15-10-16-29(4)17-11-18-30(5)19-12-20-31(6)21-22-73-83(69,70)82-84(71,72)81-51-39(55-33(8)61)43(65)47(37(26-59)77-51)78-50-38(54-32(7)60)42(64)48(36(25-58)76-50)79-53-46(68)49(41(63)35(24-57)75-53)80-52-45(67)44(66)40(62)34(23-56)74-52/h13,15,17,19,31,34-53,56-59,62-68H,9-12,14,16,18,20-26H2,1-8H3,(H,54,60)(H,55,61)(H,69,70)(H,71,72)/b28-15+,29-17+,30-19+/t31?,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44+,45+,46+,47-,48-,49+,50+,51-,52-,53+/m1/s1
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110001#_1b419a68_399a_43cf_874d_d24381d1989e
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is: Q9P019
type: Species
is encoded by: hsa:29085
has only substance units: false
name: PHPT1
initial amount: NaN

metaR SPODMn
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
reactant: MODEL1310110001#
name: superoxide dismutase, nuclear
is version of: http://identifiers.org/ec-code/1.15.1.1
modifier: MODEL1310110001#
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reversible: false
fast: false
kinetic law: MODEL1310110001#

metaM ocdca e
name: octadecanoate (n-C18:0)
constant: false
type: Species
is: HMDB00827
is: CHEBI:25629
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C18H35O2 CHARGE: -1 EHMN_ABBREVIATION: C01530
has only substance units: false
boundary condition: false
is: C01530

metaM citr L m
is: CHEBI:16349
is: SBO:0000247
name: L-citrulline
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
boundary condition: false
constant: false
is: HMDB00904
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_8695019d_17b4_489c_9971_c09172c9b164
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: SBO:0000252
name: RDH13
is encoded by: hsa:112724
is: B3KVA3
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_1ced39d1_d934_4565_abcd_8846ada682f4
boundary condition: true
is: B7Z6M3
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: DGKZ
is encoded by: hsa:8525
constant: false

metaR r1643
product: MODEL1310110001#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
reversible: true
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_d92d6964_8b37_48d0_abf3_68678da99a9a
type: Species
has only substance units: false
name: PDE9A
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:5152

http://identifiers.org/biomodels.db/MODEL1310110001#_2afad814_77f8_4e4b_985f_4e2dab1851bf
initial amount: NaN
is: O00767
name: SCD
is encoded by: hsa:6319
type: Species
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM CE5132 n
is: CHEBI:57923
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
constant: false
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
type: Species

metaM ksii core2 deg5 l
is: HMDB00143
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
name: keratan sulfate II (core 2-linked), degradation product 5
notes: FORMULA: C50H82N4O38SX CHARGE: -1
type: Species
initial concentration: 1.0
is: CHEBI:12936
boundary condition: false

metaR COAtp
is: SBO:0000185
fast: false
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
kinetic law: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110001#
name: coenzyme A transport, peroxisomal

metaM ttdca c
is: HMDB00806
constant: false
name: myristate
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C14H27O2 CHARGE: -1 INCHI: InChI=1S/C14H28O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14(15)16/h2-13H2,1H3,(H,15,16)/p-1 EHMN_ABBREVIATION: C06424
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:30807
boundary condition: false

metaR SPODMm
name: superoxide dismutase
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.15.1.1
is described by: ECO:0000304
kinetic law: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (6648.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 2 AUTHORS: PMID:12649272,PMID:9376114 NOTES:TV (8-15-2003)
reactant: MODEL1310110001#
is: SBO:0000176

metaM ksi deg28 l
is: HMDB01354
initial concentration: 1.0
name: keratan sulfate I, degradation product 28
boundary condition: false
is: CHEBI:57455
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C104H170N7O85S3 CHARGE: -3
constant: false
type: Species

metaM CE2705 n
boundary condition: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
type: Species
is: SBO:0000247
initial amount: NaN
name: quinonoid dihydrobiopterin
is: HMDB02281
is: CHEBI:15374
initial concentration: 1.0
constant: false
has only substance units: false

metaR EX o2s LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Superoxide anion exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_aee2d25f_ffe7_4a66_a5ed_ec9f59c4fe1c
is: Q59HH3
boundary condition: true
is encoded by: hsa:2618
is: SBO:0000252
initial amount: NaN
name: GART
has only substance units: false
constant: false
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_173af0ab_24ca_4615_9519_453b761c1a55
is: Q9Y227
is encoded by: hsa:9583
initial concentration: NaN
name: ENTPD4
initial amount: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
has only substance units: false

metaM ksi deg41 l
name: keratan sulfate I, degradation product 41
notes: FORMULA: C34H58N2O26 CHARGE: 0
type: Species
constant: false
initial amount: NaN
is: CHEBI:12936
is: HMDB00143
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
boundary condition: false

metaM mpdol U c
type: Species
constant: false
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog
notes: FORMULA: C1245H2040N20O220P20 CHARGE: -20
is: CHEBI:18396

metaR T4HCINNMFM
name: 4-hydroxycinnamate formation
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
reversible: false
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
product: MODEL1310110001#
is: SBO:0000176
type: Reaction

metaM HC01223 m
name: 3-hydroxy-2-methylpropanoyl-CoA(4-)
is: CHEBI:57340
has only substance units: false
boundary condition: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13?,14-,17-,18-,19+,23-/m1/s1 EHMN_ABBREVIATION: C04047
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0

metaR r1821
is: SBO:0000185
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110001#
modifier: MODEL1310110001#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
reversible: false
fast: false

metaR r1644
reactant: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_f45a0097_76f2_4435_82d2_6713cf90324c
is encoded by: hsa:54363
constant: false
boundary condition: true
type: Species
is: Q9UJM8
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: HAO1
has only substance units: false

metaR GALSIDEtg
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell NJ
product: MODEL1310110001#
is: SBO:0000185
name: galactocerebroside intracellular transport
kinetic law: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_afbf101e_6289_4730_b0a8_b8394174665d
constant: false
initial concentration: NaN
name: ALDH3B2
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: P48448
is encoded by: hsa:222
has only substance units: false
type: Species

metaR EX dcsptn1 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: docosa-4,7,10,13,16-pentaenoic acid (n-6) exchange
type: Reaction

metaR C226CPT2
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:TDV
kinetic law: MODEL1310110001#
name: C226 transport into the mitochondria
modifier: MODEL1310110001#
type: Reaction
reversible: false
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21

metaR GALASE5ly
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is: SBO:0000176
fast: false
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
type: Reaction
name: beta-galactosidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110001#_530ef7c5_a629_4bed_b9d1_504f8bc3bf19
boundary condition: true
initial concentration: NaN
is: Q06278
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:316
constant: false
is: SBO:0000252
name: AOX1

metaM phyt2ohcoa x
is: SBO:0000247
name: 2-hydroxyphytanoyl-CoA(4-)
initial concentration: 1.0
type: Species
has only substance units: false
is: HMDB01295
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:57334
notes: FORMULA: C41H70N7O18P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O18P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)32(50)40(54)70-20-19-43-30(49)17-18-44-38(53)35(52)41(6,7)22-63-69(60,61)66-68(58,59)62-21-29-34(65-67(55,56)57)33(51)39(64-29)48-24-47-31-36(42)45-23-46-37(31)48/h23-29,32-35,39,50-52H,8-22H2,1-7H3,(H,43,49)(H,44,53)(H,58,59)(H,60,61)(H2,42,45,46)(H2,55,56,57)/p-4/t26?,27?,28?,29-,32?,33-,34-,35+,39-/m1/s1 EHMN_ABBREVIATION: C07343

metaM 3hddcoa m
notes: FORMULA: C33H54N7O18P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
is: HMDB11123
constant: false
name: (S)-3-Hydroxydodecanoyl-CoA
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
is: C05279

http://identifiers.org/biomodels.db/MODEL1310110001#_d874137a_1e6a_404c_be63_e29057550d8e
is encoded by: hsa:1371
type: Species
name: CPOX
initial amount: NaN
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
is: P36551
is: SBO:0000252

metaM apoC Lys c
is: CHEBI:32551
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C6H13N2OX CHARGE: 0
is: HMDB00182
name: Apocarboxylase (Lys residue)
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_98632cb8_2432_48cc_871c_4ab4cb5d2829
constant: false
is encoded by: hsa:1650
boundary condition: true
is: P39656
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: DDOST

metaR FK
reversible: false
notes: GENE_ASSOCIATION: (197258.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.52 Confidence Level: 0 AUTHORS: NOTES:kh 1/6/03 NCD
is: SBO:0000176
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.1.52
modifier: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110001#
product: MODEL1310110001#
fast: false
name: Fucokinase

metaR OIVD2m
type: Reaction
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.168
is version of: http://identifiers.org/ec-code/1.2.4.4
is: SBO:0000176
modifier: MODEL1310110001#
reversible: false
is described by: ECO:0000269
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.8.1.4
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:1429740,PMID:2914958 NOTES:
product: MODEL1310110001#
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxobutanoate), mitochondrial
reactant: MODEL1310110001#

metaR RE3566C
is described by: ECO:0000000
name: RE3566
product: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is: SBO:0000176
reversible: true
reactant: MODEL1310110001#
type: Reaction
fast: false

metaR UMPKn
is: SBO:0000176
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.4.14
name: UMP kinase, nuclear
product: MODEL1310110001#
is described by: ECO:0000269
type: Reaction
fast: false

metaR URIK1
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.48
type: Reaction
modifier: MODEL1310110001#
name: uridine kinase (ATP:Uridine)
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (7371.1) or (83549.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.48 Confidence Level: 4 AUTHORS: PMID:11306702,PMID:12199906,PMID:8812458 NOTES:
kinetic law: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
reactant: MODEL1310110001#

metaM CE2418 m
constant: false
type: Species
name: (3S)-3-hydroxy-cis,cis-palmito-7,10-dienoyl-CoA
is: SBO:0000247
is: CHEBI:28387
initial amount: NaN
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C37H58N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-26,30-32,36,45,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t25-,26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2418
is: HMDB11123

http://identifiers.org/biomodels.db/MODEL1310110001#_2662aff7_2263_45fe_88e2_a9b6347b2e96
boundary condition: true
type: Species
is encoded by: hsa:314
initial amount: NaN
initial concentration: NaN
name: AOC2
constant: false
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_a762d0b2_05a0_4afd_8b45_7f027c4d4c67
is: P61457
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:5092
constant: false
has only substance units: false
initial amount: NaN
name: PCBD1

http://identifiers.org/biomodels.db/MODEL1310110001#_6bef9b54_f94b_4530_96f8_70f298af4c6f
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
name: DCK
initial concentration: NaN
boundary condition: true
type: Species
is: P27707
is encoded by: hsa:1633

metaR M7MASNBterg
reversible: false
kinetic law: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
fast: false
name: m7masnB transport from endoplasmic reticulum to Golgi apparatus
type: Reaction
product: MODEL1310110001#
is: SBO:0000185
reactant: MODEL1310110001#

metaM acnamp c
initial concentration: 1.0
type: Species
is: HMDB06268
has only substance units: false
is: SBO:0000247
notes: FORMULA: C11H17NO12P CHARGE: -3 INCHI: InChI=1S/C11H20NO12P/c1-4(13)12-7-5(14)2-11(19,10(17)18)24-9(7)8(16)6(15)3-23-25(20,21)22/h5-9,14-16,19H,2-3H2,1H3,(H,12,13)(H,17,18)(H2,20,21,22)/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01734 EHMN_ABBREVIATION: C06241
boundary condition: false
constant: false
name: N-Acetylneuraminate 9-phosphate
is: CHEBI:27438
initial amount: NaN

metaR NRPPHRtu
type: Reaction
kinetic law: MODEL1310110001#
name: Norepinephrine uniport
is: SBO:0000185
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
modifier: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: true

metaR UMPKm
reactant: MODEL1310110001#
type: Reaction
is: SBO:0000176
is described by: ECO:0000134
reversible: true
product: MODEL1310110001#
name: UMP kinase (mitochondrial, ATP)
fast: false
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:IT

metaR EX fru LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Fructose
type: Reaction

metaR r1931
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reversible: false
type: Reaction
modifier: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#

metaR NADtx
name: transport of NAD into peroxisome
type: Reaction
reactant: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110001#_97a6bc75_153e_4994_8b7e_2b87514a43a2
boundary condition: true
name: RRM2
is: SBO:0000252
has only substance units: false
constant: false
initial amount: NaN
is: P31350
type: Species
initial concentration: NaN
is encoded by: hsa:6241

http://identifiers.org/biomodels.db/MODEL1310110001#_5056ede6_c9a5_4702_85fd_07b2067c3ba2
type: Species
is: B2RB13
initial concentration: NaN
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:23305
name: ACSL6
is: SBO:0000252

metaR DITPtn
reversible: true
kinetic law: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
name: dITP nuclear transport
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
fast: false

metaR EX cyan LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hydrogen cyanide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_a6a65aad_74bc_47e2_b5ca_cba65c76159d
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:4702
is: B1AM93
boundary condition: true
name: NDUFA8
has only substance units: false

metaR GALK
is: SBO:0000176
fast: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.1.157
reactant: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.6
notes: GENE_ASSOCIATION: (2584.1) or (2585.2) or (2585.1) SUBSYSTEM: Galactose metabolism EC Number: 2.7.1.6 Confidence Level: 0 AUTHORS: PMID:4371022 NOTES:INVALID ECO TERM: IFH
is described by: ECO:0000000
name: galactokinase

metaM c226crn m
constant: false
is: HMDB06510
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/127055
initial concentration: 1.0
initial amount: NaN
name: cervonyl carnitine
has only substance units: false
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_63e579e7_2e44_4ba2_b01e_b5e2712c2cca
has only substance units: false
constant: false
name: BPNT1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is: O95861
is encoded by: hsa:10380
type: Species

metaR PIACGT
reversible: false
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.83
is version of: http://identifiers.org/ec-code/2.4.1.198
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
fast: false
name: phosphatidylinositol N-acetylglucosaminyltransferase
is: SBO:0000176
notes: GENE_ASSOCIATION: (5279.1) and (51227.2) and (5283.1) and (5277.2) and (9091.1) and (8818.1) or (5279.1) and (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) or (51227.1) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.2) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (5279.2) and (8818.1) or (51227.1) and (9091.2) and (5277.1) and (5283.1) and (8818.1) and (5279.2) or (51227.3) and (9091.2) and (5277.3) and (5283.1) and (5279.2) and (8818.2) or (51227.1) and (5277.1) and (5283.1) and (9091.1) and (5279.2) and (8818.1) or (51227.2) and (5283.1) and (9091.1) and (5277.2) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (9091.2) and (5277.3) and (5283.1) and (8818.2) or (51227.3) and (9091.2) and (5277.1) and (5283.1) and (8818.2) and (5279.2) or (5279.1) and (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.2) or (51227.1) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.1) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.2) and (9091.2) and (5277.1) and (5283.1) and (8818.1) or (5279.1) and (51227.1) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.2) and (5283.1) and (8818.2) or (5279.1) and (9091.2) and (51227.2) and (5277.1) and (5283.1) and (8818.2) or (51227.3) and (5283.1) and (5277.2) and (9091.1) and (8818.1) and (5279.2) or (51227.2) and (5277.3) and (5283.1) and (9091.1) and (8818.1) and (5279.2) or (5279.1) and (51227.1) and (5283.1) and (5277.2) and (9091.1) and (8818.2) or (51227.3) and (9091.2) and (5283.1) and (5277.2) and (5279.2) and (8818.1) or (5279.1) and (51227.3) and (9091.2) and (5283.1) and (5277.2) and (8818.2) or (51227.1) and (9091.2) and (5277…

http://identifiers.org/biomodels.db/MODEL1310110001#_71491ab3_fa1c_4790_b02d_5915f824f601
constant: false
boundary condition: true
type: Species
is encoded by: hsa:3295
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: E9PB82
name: HSD17B4
initial amount: NaN

metaR r1930
modifier: MODEL1310110001#
fast: false
type: Reaction
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
product: MODEL1310110001#
name: Y+LAT2 Utilized transport
is: SBO:0000185
kinetic law: MODEL1310110001#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_d672e563_f865_4537_9811_9e568b544182
initial concentration: NaN
has only substance units: false
type: Species
name: ATP5D
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:513
initial amount: NaN

metaR r0051
name: AMP:pyrophosphate phosphoribosyltransferase Purine metabolism EC:2.4.2.7
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.3.5
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (AI769281.1) or (30833.1) or (93034.1) or (22978.1) or (51251.1) or (4907.1) or (56953.1) or (57786.1) or (57665.1) SUBSYSTEM: Purine catabolism EC Number: 2.4.2.7 Confidence Level: 0 AUTHORS: PMID:6778226,PMID:692402 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110001#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110001#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_76c7f399_d478_4ccd_b0a0_c40900fbe3a9
is: SBO:0000252
is: Q16790
has only substance units: false
initial amount: NaN
name: CA9
is encoded by: hsa:768
initial concentration: NaN
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_0f6f18a4_a432_4607_aac5_78869a1a642a
initial concentration: NaN
initial amount: NaN
type: Species
is: Q6NVY1
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:26275
name: HIBCH
is: SBO:0000252

metaR XOLTRIOLtm
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110001#
name: lipid, flip-flop intracellular transport
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction

metaM co2 c
initial amount: NaN
type: Species
boundary condition: false
is: CHEBI:3313
notes: FORMULA: CO2 CHARGE: 0
initial concentration: 1.0
is: SBO:0000247
is: C00011
name: CO2
has only substance units: false
is: HMDB01967
constant: false

metaM cmp c
initial amount: NaN
type: Species
is: HMDB00095
boundary condition: false
notes: FORMULA: C9H12N3O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: C00055
name: CMP
is: CHEBI:60377
constant: false

metaR ACGAMPM
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/5.4.2.3
notes: GENE_ASSOCIATION: (5238.1) SUBSYSTEM: Aminosugar metabolism EC Number: 5.4.2.3 Confidence Level: 4 AUTHORS: PMID:11004509 NOTES:NCD
type: Reaction
product: MODEL1310110001#
kinetic law: MODEL1310110001#
name: phosphoacetylglucosamine mutase
reversible: true
is described by: ECO:0000269
fast: false
is: SBO:0000176

metaM xolest2 hs c
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: cholesterol ester
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
constant: false
is: CHEBI:17002
initial concentration: 1.0
type: Species
boundary condition: false

metaR KSII CORE2tly
reactant: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: false
fast: false
name: keratan sulfate II (core 2) transport, extracellular to lysosome
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_6ce65cd5_96b8_467c_b409_258403a1af26
constant: false
is encoded by: hsa:PRO1933
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true
name: _PRO1933_1_m
is: SBO:0000252

metaR NAGA2ly
is described by: ECO:0000000
type: Reaction
fast: false
reactant: MODEL1310110001#
modifier: MODEL1310110001#
reversible: false
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (4668.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.49 Confidence Level: 4 AUTHORS: PMID:2174888,PMID:2551294 NOTES:Alpha-galactosidase B NJ
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.49
name: N-acetylgalactosaminidase, alpha-
is: SBO:0000176

metaR EX ppa LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Propionate exchange
type: Reaction

metaM co2 e
initial amount: NaN
name: CO2
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00021 EHMN_ABBREVIATION: C00011
is: HMDB01967
is: C00011
has only substance units: false
boundary condition: false
is: CHEBI:16526
type: Species

metaM cmp e
initial amount: NaN
initial concentration: 1.0
is: HMDB00095
is: CHEBI:60377
is: SBO:0000247
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
constant: false
name: CMP(2-)
has only substance units: false
boundary condition: false
type: Species

metaR DURIt
is described by: ECO:0000000
name: deoxyuridine transport via diffusion
is: SBO:0000185
product: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

metaR IDOAASE1ly
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (3425.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.76 Confidence Level: 4 AUTHORS: PMID:1946389,PMID:2470345 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110001#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.76
reversible: false
is: SBO:0000176
modifier: MODEL1310110001#
product: MODEL1310110001#
fast: false
name: alpha-L-iduronidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110001#_cf2faa09_9c83_4873_88c9_26376cccb77f
initial amount: NaN
name: NME7
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:29922
type: Species
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_bd11c31a_8845_4790_b0d8_c8e7b060eb50
name: CYP1B1
has only substance units: false
is: SBO:0000252
is: Q16678
boundary condition: true
type: Species
is encoded by: hsa:1545
initial amount: NaN
constant: false
initial concentration: NaN

metaM dgtp n
type: Species
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00252 EHMN_ABBREVIATION: C00286
has only substance units: false
is: CHEBI:16497
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: dGTP
is: C00286
constant: false
is: HMDB01440
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_3ced974b_92da_4596_8173_8fa12e69d2a7
name: GPX1
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:2876
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_07a699bd_0e4d_42be_9740_c240f3d357a4
has only substance units: false
constant: false
boundary condition: true
name: RRM1
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6240
is: P23921

http://identifiers.org/biomodels.db/MODEL1310110001#_577379fc_72b8_4d1c_8702_b48a835eb0b6
is encoded by: hsa:124583
name: CANT1
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
is: Q8WVQ1
is: SBO:0000252
has only substance units: false
constant: false

metaM CE2705 c
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17)/p+1/t3-,4?,6+/m0/s1 EHMN_ABBREVIATION: CE2705
constant: false
initial concentration: 1.0
name: quinonoid dihydrobiopterin
type: Species
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:36781

metaR DURIPP
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11278417,PMID:12849978,PMID:6087295,PMID:9305963 NOTES:JLR
reactant: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.2.1
is described by: ECO:0000269
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.2.3
fast: false
name: deoxyuridine phosphorylase
type: Reaction
reversible: true
kinetic law: MODEL1310110001#

metaR TRDR
modifier: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (7296.3) or (7296.1) or (7296.4) or (7296.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:8577704,PMID:8999974 NOTES:
kinetic law: MODEL1310110001#
reversible: false
name: thioredoxin reductase (NADPH)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.8.1.9
is described by: ECO:0000269
reactant: MODEL1310110001#
fast: false
product: MODEL1310110001#

metaR SPODMx
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000176
type: Reaction
fast: false
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.15.1.1
notes: GENE_ASSOCIATION: (6647.1) SUBSYSTEM: ROS detoxification EC Number: 1.15.1.1 Confidence Level: 4 AUTHORS: PMID:1332049,PMID:3889846 NOTES:JLR
reactant: MODEL1310110001#
is described by: ECO:0000269
reversible: false
name: superoxide dismutase, peroxisome

metaM gam c
is: CHEBI:17315
is: HMDB01514
constant: false
name: D-Glucosamine
is: C00329
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
is: SBO:0000247
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_73193180_4d4c_4d25_8254_567f7d19d412
is: P14060
name: HSD3B1
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:3283
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_25457b82_72cc_407e_ab89_cf4ade6f393c
initial concentration: NaN
type: Species
is encoded by: hsa:1798
name: DPAGT1
is: SBO:0000252
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN

metaM CE5132 c
initial concentration: 1.0
is: SBO:0000247
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
has only substance units: false
type: Species
constant: false
boundary condition: false
initial amount: NaN
notes: FORMULA: C11H14O19P3R2 CHARGE: -5 EHMN_ABBREVIATION: CE5132
is: CHEBI:57923

metaR GLUDym
name: glutamate dehydrogenase (NADP), mitochondrial
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000176
reversible: true
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.4.1.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2747.1) or (2746.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.4.1.4 Confidence Level: 4 AUTHORS: PMID:12324473,PMID:3368458 NOTES:
reactant: MODEL1310110001#
fast: false
product: MODEL1310110001#

metaM gt3 hs g
initial amount: NaN
is: CHEBI:28424
boundary condition: false
type: Species
name: GT3
constant: false
notes: FORMULA: C63H104N4O36FULLRCO CHARGE: -3
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

metaR NACDe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: release of nicotinate at the basolateral surface
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_09a9acad_e367_46ce_84c4_160025274b4a
initial amount: NaN
is: P49902
constant: false
type: Species
name: NT5C2
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is encoded by: hsa:22978

http://identifiers.org/biomodels.db/MODEL1310110001#_db81dc51_6a68_4dc2_8c47_003e0f740003
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: P23378
name: GLDC
is encoded by: hsa:2731

metaR FAOXC123x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:3)x
type: Reaction

metaM xolest2 hs e
constant: false
type: Species
notes: FORMULA: C27H45FULLR2CO2 CHARGE: 0
is: CHEBI:17002
is: SBO:0000247
boundary condition: false
name: cholesterol ester
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaM s2l2fn2m2masn e
notes: FORMULA: C90H145N6O65X CHARGE: -2
is: HMDB00244
is: CHEBI:3554
is: C00255
name: PA6
type: Species
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false

metaM cmp g
is: SBO:0000247
is: HMDB00095
is: CHEBI:60377
constant: false
initial concentration: 1.0
notes: FORMULA: C9H12N3O8P CHARGE: -2 INCHI: InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/p-2/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00060 EHMN_ABBREVIATION: C00055
name: CMP(2-)
initial amount: NaN
boundary condition: false
type: Species
has only substance units: false

metaR CYTK7n
name: cytidylate kinase (CMP,UTP),nuclear
modifier: MODEL1310110001#
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
reversible: true
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_cc970892_b518_4bea_b7ee_a77813dcc2d0
name: ECHS1
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:1892
boundary condition: true
is: P30084
is: SBO:0000252
constant: false

metaM citr L e
initial concentration: 1.0
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
name: citr_L[e]
constant: false
is: HMDB00904
boundary condition: false
initial amount: NaN
is: CHEBI:16349
has only substance units: false
is: SBO:0000247
type: Species

metaR AG13T10g
type: Reaction
reactant: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (79369.1) or (10678.1) or (11041.1) or (146712.1) or (374907.1) or (93010.1) or (374907.2) or (10331.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
product: MODEL1310110001#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is: SBO:0000176
reversible: false

metaR FAOXC2251836m
is version of: http://identifiers.org/ec-code/1.3.8.1
name: Beta oxidation of fatty acid
is: SBO:0000176
reactant: MODEL1310110001#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_2 rounds of beta-ox, plus a loss of 2 degrees of desatuartion, so no fad is oxidized peroxisomal (very long chain FA) c22:5,n-6 -> c18:3, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000

metaR r2120
fast: false
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
product: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110001#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_78c5b73f_e963_4104_95dd_026b5194c118
is encoded by: hsa:28232
is: Q9UIG8
boundary condition: true
initial amount: NaN
has only substance units: false
name: SLCO3A1
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaR XOLEST2te
product: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:
is: SBO:0000185
type: Reaction
name: cholesterol ester transporter

http://identifiers.org/biomodels.db/MODEL1310110001#_a74e2246_7494_4f14_b95b_bbdc7e80d5a9
name: ODC1
initial concentration: NaN
is: SBO:0000252
is: P11926
initial amount: NaN
is encoded by: hsa:4953
type: Species
constant: false
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_61b2db3b_4c2a_4c67_a65a_d4842bb96a1a
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ACSS2
initial concentration: NaN
is: Q5QPH3
is encoded by: hsa:55902
type: Species

metaR C226CPT1
reversible: false
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1374.1) or (1375.2) or (1375.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TDV
fast: false
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#
name: carnitine C22:6 transferase
kinetic law: MODEL1310110001#
is described by: ECO:0000000

metaR COAtg
kinetic law: MODEL1310110001#
fast: false
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
reversible: true
name: CoA transport in Golgi via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:

metaM gam e
boundary condition: false
name: D-Glucosamine
is: C00329
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H14NO5 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00279 EHMN_ABBREVIATION: C00329
initial amount: NaN
has only substance units: false
type: Species
is: HMDB01514
constant: false
is: CHEBI:17315

metaR ACACT1x
is version of: http://identifiers.org/ec-code/2.3.1.9
fast: false
modifier: MODEL1310110001#
name: acetyl-CoA C-acetyltransferase, mitochondrial
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (39.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.1.9 Confidence Level: 4 AUTHORS: PMID:11108725 NOTES:NCD NJ - added peroxisomal version
type: Reaction
product: MODEL1310110001#
reactant: MODEL1310110001#
reversible: false
is: SBO:0000176
is described by: ECO:0000134

metaM citr L c
is: SBO:0000247
name: L-citrulline
notes: FORMULA: C6H13N3O3 CHARGE: 0 INCHI: InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00277
type: Species
initial concentration: 1.0
boundary condition: false
is: CHEBI:16349
has only substance units: false
initial amount: NaN
constant: false
is: HMDB00904

http://identifiers.org/biomodels.db/MODEL1310110001#_38f425c0_3044_41c0_9db1_25fea400824f
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000297
type: Species
has part: Q8WYR1
is encoded by: hsa:23533
has only substance units: false
name: PIK3R5:PIK3CG
initial amount: NaN

metaM dhcholestanate c
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H45O4 CHARGE: -1 INCHI: InChI=1S/C27H46O4/c1-16(6-5-7-17(2)25(30)31)20-8-9-21-24-22(11-13-27(20,21)4)26(3)12-10-19(28)14-18(26)15-23(24)29/h16-24,28-29H,5-15H2,1-4H3,(H,30,31)/t16-,17?,18+,19-,20-,21+,22+,23-,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01313 EHMN_ABBREVIATION: C04554
is: SBO:0000247
initial amount: NaN
is: HMDB00359
type: Species
constant: false
boundary condition: false
is: CHEBI:16577

metaR UGT1A10r
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (54576.1) SUBSYSTEM: Steroid metabolism EC Number: 2.4.1.17 Confidence Level: 1 AUTHORS: PMID:7945246 NOTES:bil is taken up by cell - made reversible (actual measurements of deltaG/reversibility not described in literature currently) NJ. rate of estradiol (alpha and beta) glucuronidation by human bilirubin UGT quantified
is version of: http://identifiers.org/ec-code/2.4.1.17
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000134
reversible: true
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000176
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal
type: Reaction

metaR r2121
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
type: Reaction
is: SBO:0000185
modifier: MODEL1310110001#
is described by: ECO:0000000
fast: false
reversible: true
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110001#
product: MODEL1310110001#

metaR C9BRxtc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dimethylnonanoylcarnitine from peroxisomes to cytosol
type: Reaction

metaR r0321
modifier: MODEL1310110001#
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (AA664770.1) or (AI684467.1) or (8833.1) SUBSYSTEM: Cholesterol metabolism EC Number: 6.2.1.16 Confidence Level: 0 AUTHORS: PMID:4073493 NOTES:
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.3.5.2
product: MODEL1310110001#
name: Acetoacetate:CoA ligase (AMP-forming) Butanoate metabolism EC:6.2.1.16
is described by: ECO:0000000
kinetic law: MODEL1310110001#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_917db2e9_aa00_4160_9d65_274846404062
initial concentration: NaN
initial amount: NaN
is: Q9Y5L3
constant: false
is: SBO:0000252
type: Species
name: ENTPD2
boundary condition: true
is encoded by: hsa:954
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_70239636_8575_478e_b460_cd55568fd4e8
has only substance units: false
initial amount: NaN
name: OCRL
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:4952
boundary condition: true
is: Q01968

http://identifiers.org/biomodels.db/MODEL1310110001#_f44726f3_ade3_4c88_bf71_b9c26a431f37
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
name: CMAS
type: Species
is: Q8NFW8
initial amount: NaN
is encoded by: hsa:55907
is: SBO:0000252

metaR C12OHc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdodecanoylcarnitinec
type: Reaction

metaM HC02213 c
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial concentration: 1.0
is: CHEBI:28031
is: SBO:0000247
has only substance units: false
name: prostaglandin-e3
boundary condition: false

metaR PGCD
type: Reaction
reversible: false
reactant: MODEL1310110001#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26227.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.1.1.95 Confidence Level: 4 AUTHORS: PMID:10713460 NOTES:
kinetic law: MODEL1310110001#
is: SBO:0000176
fast: false
product: MODEL1310110001#
name: phosphoglycerate dehydrogenase
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.95

metaR C30CPT1
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of propionylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_7afaf81a_2d59_4508_ad46_980a95fc5bb1
type: Species
constant: false
name: ACLY
initial amount: NaN
is encoded by: hsa:47
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: P53396
boundary condition: true

metaR RE2954C
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.1.40
notes: GENE_ASSOCIATION: (5315.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.40 Confidence Level: 0 AUTHORS: PMID:10585400,PMID:8967971 NOTES:
is: SBO:0000176
is described by: ECO:0000000
name: RE2954
fast: false
product: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction

metaR FAOXC14C14OHm
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C14OH)m
type: Reaction

metaR HGNTOR
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.5
reversible: false
type: Reaction
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (3081.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.5 Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000269
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
modifier: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_bdb3d381_70c5_4d30_8f5d_1877e631848c
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AU149534
constant: false
has only substance units: false
type: Species
initial amount: NaN
name: _AU149534_1_m
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_665652f8_8108_4efc_84df_52864496ada3
initial amount: NaN
name: LDHC
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:3948
boundary condition: true
type: Species

metaR FAOXC81C61x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)x
type: Reaction

metaM vitd3 c
name: calciol
is: CHEBI:28940
constant: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00876

metaM xylu D c
is: SBO:0000247
constant: false
is: HMDB01644
initial concentration: 1.0
type: Species
is: CHEBI:17140
boundary condition: false
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m1/s1
name: D-xylulose
initial amount: NaN

metaM melatn c
initial amount: NaN
boundary condition: false
constant: false
is: CHEBI:16796
is: SBO:0000247
name: melatonin
type: Species
is: HMDB01389
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C13H16N2O2 CHARGE: 0 INCHI: InChI=1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C01598

http://identifiers.org/biomodels.db/MODEL1310110001#_ab1181e3_c5c6_4979_8452_aea10e58f197
has only substance units: false
name: GALNTL2
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is: Q8N3T1
constant: false
is encoded by: hsa:117248
is: SBO:0000252

metaM txa2 r
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
name: thromboxane A2(1-)
has only substance units: false
is: SBO:0000247
is: HMDB01452
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:57445

metaR EX mercplaccys LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3-mercaptolactate-cysteine disulfide exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_9f215134_19f2_43f1_9273_a39c89d86560
is encoded by: hsa:5151
initial concentration: NaN
boundary condition: true
is: O60658
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
name: PDE8A
type: Species

metaR EX dhdascb LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dehydroascorbide(1-)
type: Reaction

metaR FATP3t
product: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
reversible: true
is: SBO:0000185
modifier: MODEL1310110001#
name: fatty acid electroneutral transport
is described by: ECO:0000269
fast: false

metaR Asn X Ser Thrtr
reactant: MODEL1310110001#
is described by: ECO:0000269
reversible: true
type: Reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: Asn-X-Ser/Thr transport (from ER to lysosome)
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:10823827,PMID:12845534 NOTES:
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_ab94dd78_91f2_4eca_87fb_b67406d39b6c
constant: false
name: GALNT12
boundary condition: true
has only substance units: false
is: Q8IXK2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:79695
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_5bf39e88_ce78_48f5_8f3c_29191f227957
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true
is: Q14032
is encoded by: hsa:570
name: BAAT

metaM HC02213 e
boundary condition: false
type: Species
is: CHEBI:28031
notes: FORMULA: C20H29O5 CHARGE: -1 INCHI: InChI=1S/C20H30O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h3-4,6-7,12-13,15-17,19,21,23H,2,5,8-11,14H2,1H3,(H,24,25)/b6-3-,7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C06439
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: prostaglandin-e3
constant: false
initial amount: NaN

metaR FAOXC61x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_09d2b4e4_fe1d_4c8f_b06c_eb5f52a235bc
is encoded by: hsa:AW277253
is: SBO:0000252
constant: false
initial amount: NaN
name: _AW277253_1_c
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_925b9310_9888_4ba3_8d3c_97eb5cf828f8
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: GSTZ1
has only substance units: false
constant: false
type: Species
is encoded by: hsa:2954
is: SBO:0000252

metaM 20ahchsterol m
name: 20-hydroxycholesterol
type: Species
initial concentration: 1.0
has only substance units: false
is: HMDB06283
is: CHEBI:1296
notes: FORMULA: C27H46O2 CHARGE: 0 INCHI: InChI=1S/C27H46O2/c1-18(2)7-6-14-27(5,29)24-11-10-22-21-9-8-19-17-20(28)12-15-25(19,3)23(21)13-16-26(22,24)4/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t20-,21-,22-,23-,24-,25-,26-,27-/m0/s1 EHMN_ABBREVIATION: C05500
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247

metaR SCP21x
product: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
is described by: ECO:0000269
reversible: true
name: Sterol carrier protein 2
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 4 AUTHORS: PMID:1703300 NOTES:intracellular transport, mechanism details not presently known NJ
is: SBO:0000185

metaM 4abut m
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
is: C00334
is: CHEBI:16865
name: 4-Aminobutanoate
initial concentration: 1.0
is: HMDB00112
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00284 EHMN_ABBREVIATION: C00334
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_d2f44768_a4cb_469c_b91d_a1e2b0aa34a9
type: Species
boundary condition: true
constant: false
initial concentration: NaN
is encoded by: hsa:196951
is: Q96M60
initial amount: NaN
has only substance units: false
name: C15orf33
is: SBO:0000252

metaM zymstnl r
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-21,23-24,28H,6-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1 EHMN_ABBREVIATION: C03845
name: 5alpha-cholest-8-en-3beta-ol
has only substance units: false
is: SBO:0000247
is: HMDB06841
initial amount: NaN
is: CHEBI:16608
boundary condition: false
initial concentration: 1.0
type: Species
constant: false

metaM gacpail hs r
initial concentration: 1.0
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: HMDB01401
type: Species
has only substance units: false
name: glucosaminyl-acylphosphatidylinositol
is: CHEBI:61548
constant: false
is: C00092
boundary condition: false
is: SBO:0000247

metaR ADCim
reversible: false
type: Reaction
name: Acetoacetate decarboxylation (irreversible), mitochondrial
kinetic law: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Propanoate metabolism EC Number: 4.1.1.4 Confidence Level: 2 AUTHORS: NOTES:TDV (Voet & Voet pg 581) Non-enzymatic decarboxylation; spontaneous reaction added "m" suffix - NCD
reactant: MODEL1310110001#
fast: false
is: SBO:0000176

metaM 4hbzcoa m
constant: false
boundary condition: false
is: SBO:0000247
name: 4-hydroxybenoyl-CoA
is: HMDB06467
notes: FORMULA: C28H36N7O18P3S CHARGE: -4 INCHI: InChI=1/C28H40N7O18P3S/c1-28(2,22(39)25(40)31-8-7-18(37)30-9-10-57-27(41)15-3-5-16(36)6-4-15)12-50-56(47,48)53-55(45,46)49-11-17-21(52-54(42,43)44)20(38)26(51-17)35-14-34-19-23(29)32-13-33-24(19)35/h3-6,13-14,17,20-22,26,36,38-39H,7-12H2,1-2H3,(H,30,37)(H,31,40)(H,45,46)(H,47,48)(H2,29,32,33)(H2,42,43,44)/t17-,20?,21-,22+,26-/m1/s1
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_d0d75806_2721_46dc_81e2_5c1a053e718d
boundary condition: true
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:10166
is: SBO:0000252
is: Q9Y619
initial amount: NaN
name: SLC25A15

metaR EX orot LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of orotate
type: Reaction

metaM retinal cis 9 c
name: all-trans-retinal
has only substance units: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:17898
is: HMDB01358
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+ EHMN_ABBREVIATION: CE5575
constant: false
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_09aea0a1_a8ce_4772_80ee_e340fd10ae52
initial amount: NaN
name: PEMT
is encoded by: hsa:10400
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN

metaM acetone c
type: Species
name: acetone
boundary condition: false
has only substance units: false
constant: false
is: CHEBI:15347
is: HMDB01659
initial concentration: 1.0
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
initial amount: NaN
is: SBO:0000247

metaR PROSTGI2tr
name: Prostaglandin I2 transport (ER)
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:12827517,PMID:12883891,PMID:9187257 NOTES:
is described by: ECO:0000269
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
reversible: true

metaM accoa x
initial concentration: 1.0
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
type: Species
initial amount: NaN
name: Acetyl-CoA
is: HMDB01206
is: SBO:0000247
boundary condition: false
is: CHEBI:57288
is: C00024
constant: false
has only substance units: false

metaM vitd3 e
is: CHEBI:28940
constant: false
is: SBO:0000247
name: calciol
initial concentration: 1.0
initial amount: NaN
type: Species
is: HMDB00876
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1
boundary condition: false
has only substance units: false

metaM 3dphb m
notes: FORMULA: C57H85O3 CHARGE: -1 INCHI: InChI=1/C57H86O3/c1-44(2)21-12-22-45(3)23-13-24-46(4)25-14-26-47(5)27-15-28-48(6)29-16-30-49(7)31-17-32-50(8)33-18-34-51(9)35-19-36-52(10)37-20-38-53(11)39-40-54-43-55(57(59)60)41-42-56(54)58/h21,23,25,27,29,31,33,35,37,39,41-43,58H,12-20,22,24,26,28,30,32,34,36,38,40H2,1-11H3,(H,59,60)/b45-23+,46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+
is: HMDB06251
type: Species
initial amount: NaN
constant: false
name: 3-Decaprenyl-4-hydroxybenzoate
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
has only substance units: false

metaR FAOXC12DCc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: formation of dodecanedioyl carnitine
type: Reaction

metaM m3mpdol U c
is: CHEBI:37632
name: (alpha-D-mannosyl)3-beta-D-mannosyl-diacetylchitodiphosphodolichol, human uterine homolog
boundary condition: false
has only substance units: false
type: Species
constant: false
is: SBO:0000247
notes: FORMULA: C1425H2340N20O370P20 CHARGE: -20
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_18686d4c_57a6_49d1_ae03_f69d36ab647e
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AA526438
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: _AA526438_1_c

metaR CSNAT2x
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
name: carnitine dimethyl nonanoyl transferase, revsible, peroxisomal
modifier: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (54677.1) or (1384.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:15464416,PMID:7829107 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.7
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.137
reversible: true
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_a996b2c3_90ce_43cf_9073_d4e63c9be9ce
has only substance units: false
type: Species
is encoded by: hsa:AA081045
constant: false
name: _AA081045_1_e
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_e071a357_7fe6_4097_b570_9508a0b39b0f
initial amount: NaN
initial concentration: NaN
is: O60488
name: ACSL4
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:2182
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_930deef6_bca1_4420_9487_207e55141345
initial concentration: NaN
is: Q8TEQ8
initial amount: NaN
is encoded by: hsa:84720
is: SBO:0000252
type: Species
constant: false
has only substance units: false
name: PIGO
boundary condition: true

metaM tddedi2coa m
type: Species
is: HMDB00792
is: SBO:0000247
name: trans2,6dodecadienoylcoa
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
has only substance units: false
is: C08277
initial concentration: 1.0
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_3bed937a_9890_48b3_85a2_b95dd378dc51
initial concentration: NaN
is encoded by: hsa:T83654
constant: false
initial amount: NaN
boundary condition: true
type: Species
has only substance units: false
name: _T83654_1_c
is: SBO:0000252

metaR 5ADTSTSTERONESte
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
name: sulfonated testosterone transport
is described by: ECO:0000000
product: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction

metaM acetol c
is: SBO:0000247
has only substance units: false
is: HMDB06961
name: hydroxyacetone
type: Species
constant: false
notes: FORMULA: C3H6O2 CHARGE: 0 INCHI: InChI=1S/C3H6O2/c1-3(5)2-4/h4H,2H2,1H3
is: CHEBI:27957
initial amount: NaN
boundary condition: false
initial concentration: 1.0

metaR TRPt
type: Reaction
name: L-tryptophan transport
is described by: ECO:0000269
product: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
is: SBO:0000185
modifier: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
reactant: MODEL1310110001#

metaR VACCt
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reversible: true
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
name: fatty acid transport via diffusion
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
fast: false

metaR HISD
reactant: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (3034.1) SUBSYSTEM: Histidine metabolism EC Number: 4.3.1.3 Confidence Level: 4 AUTHORS: PMID:8530107 NOTES:
fast: false
name: histidase
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reversible: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/4.3.1.3
is described by: ECO:0000269

metaM hs deg17 l
name: heparan sulfate, degradation product 17
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB02704
type: Species
notes: FORMULA: C43H65N2O48S4 CHARGE: -5
is: CHEBI:21338
initial amount: NaN
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_486ac799_c697_498b_8b4b_27f36ac8f0ff
has only substance units: false
constant: false
type: Species
name: GCNT1
is: SBO:0000252
is encoded by: hsa:2650
is: Q02742
initial concentration: NaN
initial amount: NaN
boundary condition: true

metaM dmnoncrn c
constant: false
type: Species
notes: FORMULA: C18H37NO4 CHARGE: 0
boundary condition: false
has only substance units: false
name: 4,8-dimethylnonanoyl carnitine
initial concentration: 1.0
is: SBO:0000247
is: HMDB06202
initial amount: NaN

metaM lneldccrn m
initial amount: NaN
type: Species
has only substance units: false
is: HMDB06461
name: Linoelaidyl carnitine
boundary condition: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_9364a040_a9a9_4e64_a7a1_d9b646897faf
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: B7Z9T9
name: PDE6B
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5158
constant: false
type: Species

MODEL1310110001#
species: metaM fuc L c
species: metaM ksi deg38 l
type: ModifierSpeciesReference
species: metaM Lcystin e
species: metaM lnlccoa m
species: metaM HC10852 r
species: metaM cmp m
species: metaM co2 m
species: metaM ametam c
species: metaM e4hglu m
species: metaM mescoa m
species: metaM 4nphsf e
species: metaM q10 c
species: metaM Rtotal2coa c
species: metaM CE2424 m
species: metaM HC00591 c
species: metaM 3deccrn e
species: metaM c6dc c
name: DPM3:DPM1:DPM2
species: metaM nh4 c
species: metaM ahcys c
species: metaM hdca l
species: metaM CE2839 e
species: metaM icit c
species: metaM phe L e
species: metaM glcur l
species: metaM tddedicoa m
species: metaM CE2432 m
species: metaM g3m8masn r
species: metaM pchol hs e
species: metaM occoa c
species: metaM CE2416 x
species: metaM gluside hs l
species: metaM m5masnB2 g
species: metaM 4mptnl e
species: metaM clpnd e
species: metaM cholcoar r
species: metaM 2ddecdicoa m
species: metaM subeac x
species: metaM docohexcoa m
species: metaM phyt2ohcoa x
species: metaM 2hexdtricoa m
species: metaM sebcoa c
species: metaM dad 2 c
species: metaM dpcoa c
species: metaM 4pyrdx c
species: metaM anth e
species: metaM 3mldz c
species: metaM 3aib D c
species: metaM adrnl c
species: metaM ncam c
species: metaM 25aics c
species: metaM pect e
species: metaM c5dc c
species: metaM galside hs c
species: metaM adrncrn c
species: metaM hdd2coa m
species: metaM ksi pre27 g
species: metaM odecoa c
stoichiometry: 0.011658
species: metaM octe5coa m
species: metaM pi e
species: metaM xol7ah2al c
species: metaM dgsn c
species: metaM xylu D c
species: metaM btn m
species: metaM thr L c
species: metaM duri e
value: -1000.0
value: 1000.0
species: metaM prostgd2 e
species: metaM pchol hs m
species: metaM CE5118 m
species: metaM Ser Gly Ala X Gly l
species: metaM nadh r
species: metaM xol7ah c
species: metaM tdchola c
species: metaM gthrd r
is: SBO:0000297
species: metaM tmndnccoa c

metaR DADAe
fast: false
modifier: MODEL1310110001#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110001#
type: Reaction
name: Deoxyadenosine deaminase, extracellular
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:adenosine deaminase has been found on cell surface in human (Gonzales-Gronow et al, JBC, 2004,279,20993-20998). IT
is described by: ECO:0000269
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.5.4.4
product: MODEL1310110001#

metaR MI1345PP
product: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reactant: MODEL1310110001#
name: inositol-1,3,4,5-trisphosphate 5-phosphatase
kinetic law: MODEL1310110001#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.3.36
fast: false
is version of: http://identifiers.org/ec-code/3.1.3.56
modifier: MODEL1310110001#
reversible: false
is version of: http://identifiers.org/ec-code/3.1.3.86

metaR FAOXC1811601m
modifier: MODEL1310110001#
is: SBO:0000176
reversible: false
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.8.1
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
name: Beta oxidation fatty acid
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_2e300e3d_36ac_4884_bf60_2f0fa6f95075
is: P13804
is encoded by: hsa:2108
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
name: ETFA
type: Species
initial concentration: NaN
boundary condition: true

metaR HPDCACRNt
modifier: MODEL1310110001#
is described by: ECO:0000269
is: SBO:0000185
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
type: Reaction
reversible: false
name: heptadecanoate transport into the mitochondria
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#

metaM octd11ecoa m
name: 11-octadecenoylcoa
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB06294
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247

metaR CITtbm
reversible: true
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with PEP IF
fast: false
is: SBO:0000185
type: Reaction
modifier: MODEL1310110001#
name: citrate transport, mitochondrial
reactant: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000269

metaM decdicoa c
type: Species
has only substance units: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: HMDB01168
name: decadienoylcoa
is: SBO:0000247

metaR EX duri LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Deoxyuridine
type: Reaction

metaR RE0688E
kinetic law: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#
is: SBO:0000176
reactant: MODEL1310110001#
fast: false
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
name: RE0688
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:

metaM adn c
boundary condition: false
type: Species
is: SBO:0000247
is: HMDB00050
is: CHEBI:16335
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
name: Adenosine
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
is: C00212

metaR r0594
is version of: http://identifiers.org/ec-code/1.2.1.3
reactant: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Lysine metabolism EC Number: 1.2.1.31 Confidence Level: 0 AUTHORS: PMID:2160277 NOTES:
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reversible: true
type: Reaction
name: L-2-Aminoadipate-6-semialdehyde:NAD+ 6-oxidoreductase Lysine degradation EC:1.2.1.31
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_64c1bc1a_ec6a_451c_b955_fd1ea73e66f5
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
name: DECR1
is: Q16698
is encoded by: hsa:1666
initial amount: NaN

metaM ksi pre8 g
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 8
type: Species
constant: false
notes: FORMULA: C115H186N8O88S2X CHARGE: -3
is: SBO:0000247
is: CHEBI:28067
initial amount: NaN
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_ca9c14ef_4cf3_4385_bc08_36516d3a37b9
boundary condition: true
is: SBO:0000252
name: HAO2
is encoded by: hsa:51179
has only substance units: false
type: Species
initial concentration: NaN
initial amount: NaN
constant: false

metaM c226crn c
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/127055
initial concentration: 1.0
constant: false
notes: FORMULA: C29H45NO4 CHARGE: 0 INCHI: InChI=1/C29H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h6-7,9-10,12-13,15-16,18-19,21-22,27H,5,8,11,14,17,20,23-26H2,1-4H3/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+
name: cervonyl carnitine
is: HMDB06510
boundary condition: false

metaR TTDCPT1
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1374.1) or (1375.2) or (126129.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
product: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
name: carnitine O-palmitoyltransferase

metaR 4MPTNLte
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
type: Reaction
name: 4-methylpentanal transport

http://identifiers.org/biomodels.db/MODEL1310110001#_74c85e13_4ae5_47f1_856a_2f9bee2f564b
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
name: PAPSS2
is: SBO:0000252
is encoded by: hsa:9060
type: Species
is: O95340

http://identifiers.org/biomodels.db/MODEL1310110001#_1352e2db_1320_4c16_bb73_11efd8f569f4
type: Species
constant: false
boundary condition: true
is: Q9HC21
is encoded by: hsa:60386
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: SLC25A19
initial amount: NaN

metaR TMNDNCt
is described by: ECO:0000000
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110001#
is: SBO:0000185
type: Reaction
fast: false
name: fatty acid transport via diffusion
reversible: true
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_5ead2025_7f6c_4bc2_afc2_14ff1a12fa13
name: HADHB
has only substance units: false
constant: false
is encoded by: hsa:3032
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: P55084

http://identifiers.org/biomodels.db/MODEL1310110001#_b99b25d4_b676_4e71_b213_4b87d84bb1d4
initial concentration: NaN
type: Species
name: _AA203143_1_c
has only substance units: false
is encoded by: hsa:AA203143
initial amount: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaR G14T14g
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
modifier: MODEL1310110001#
reversible: false
notes: GENE_ASSOCIATION: (8703.1) or (8704.2) or (8704.1) or (2683.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110001#
reactant: MODEL1310110001#

metaM ha l
type: Species
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16336
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
has only substance units: false
name: hyaluronan

metaM dgmp c
initial concentration: 1.0
type: Species
has only substance units: false
is: CHEBI:57673
constant: false
is: SBO:0000247
is: C00362
initial amount: NaN
name: dGMP
is: HMDB01044
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_8f05c4f7_762b_4bc6_a3f5_887aba5b4694
name: FTH1
initial amount: NaN
has only substance units: false
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:2495
is: P02794
initial concentration: NaN
boundary condition: true

metaR r0033
name: ATP:dephospho-CoA 3-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.24
modifier: MODEL1310110001#
fast: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: false
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.24 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5

metaM ctp n
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: HMDB00082
constant: false
boundary condition: false
name: CTP(4-)
has only substance units: false
is: CHEBI:37563

metaR EX glu L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Glutamate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_eb67a081_7776_4e4a_b53c_12dd2f0248ea
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:57282
constant: false
initial amount: NaN
name: SLC4A10
is: B7Z1R0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_b5cef3d7_e922_4ce5_b5e8_59aeec268327
name: ATP1A2
constant: false
is: P50993
boundary condition: true
initial amount: NaN
is encoded by: hsa:477
initial concentration: NaN
type: Species
is: SBO:0000252
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_538784ba_cfb2_41fa_a9ef_49b0eec5f63a
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
is: P51648
initial concentration: NaN
constant: false
name: ALDH3A2
is encoded by: hsa:224
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_f68eb2bb_6784_4bb0_9eed_36fecebbe727
is encoded by: hsa:3290
boundary condition: true
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
name: HSD11B1
initial amount: NaN
type: Species

metaR TTDCPT2
reversible: false
product: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
fast: false
name: carnitine transferase
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_89c35b3d_b25d_4c51_adf5_e499207e6f57
is: SBO:0000252
is: O75489
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:4722
boundary condition: true
name: NDUFS3

metaM 3thexddcoa c
initial amount: NaN
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
boundary condition: false
type: Species
initial concentration: 1.0
name: 3-hydroxy trans7,10-hexadecadienoylcoa
constant: false
has only substance units: false
is: HMDB02014
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_42066a1b_6f16_4c2f_bae6_b384ce4b3cd5
name: HSD17B4
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:3295
has only substance units: false
type: Species
initial concentration: NaN
is: E9PB82

metaR FAOXC15NADPx
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid alpha oxidation(2-Hydroxyphytanoyl-CoA)(nadp)x
type: Reaction

metaR EX hxan LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hypoxanthine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_e3402ccf_19e0_4ca6_be25_c56574cf0bb4
is encoded by: hsa:3295
is: E9PB82
boundary condition: true
is: SBO:0000252
name: HSD17B4
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
has only substance units: false

metaR S6TASE13ly
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110001#
type: Reaction
fast: false
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.1.6.14
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
product: MODEL1310110001#

metaR r0596
modifier: MODEL1310110001#
type: Reaction
name: 3-hydroxyisobutyryl-CoA hydrolase beta-Alanine metabolism / Propanoate metabolism EC:3.1.2.4
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: CoA synthesis EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:10989434,PMID:8188708,PMID:8824301 NOTES:
reversible: false
is: SBO:0000176
fast: false

metaM ctp m
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species
is: HMDB00082
constant: false
is: CHEBI:37563
initial concentration: 1.0
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063

metaR DOLASNT Ler
reversible: false
product: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.119
fast: false
reactant: MODEL1310110001#
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (liver)
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_2024a8ae_31e5_42ab_b4d3_8e963c471f97
type: Species
boundary condition: true
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:BC005314
name: _BC005314_1_x
has only substance units: false

metaM dgmp e
is: CHEBI:57673
initial amount: NaN
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
type: Species
name: dGMP(2-)
notes: FORMULA: C10H12N5O7P CHARGE: -2 INCHI: InChI=1S/C10H14N5O7P/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(22-6)2-21-23(18,19)20/h3-6,16H,1-2H2,(H2,18,19,20)(H3,11,13,14,17)/p-2/t4-,5+,6+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00306 EHMN_ABBREVIATION: C00362
is: HMDB01044
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_dac924f5_258b_4de2_8f6b_b8350fd98267
is encoded by: hsa:2990
constant: false
initial concentration: NaN
is: SBO:0000252
is: P08236
boundary condition: true
name: GUSB
initial amount: NaN
type: Species
has only substance units: false

metaR r0591
modifier: MODEL1310110001#
name: Dephospho-CoA nucleotidohydrolase Pantothenate and CoA biosynthesis EC:3.6.1.9
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.2.1.5
reversible: true
is described by: ECO:0000000
product: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176
fast: false

metaR UDPGALtg
modifier: MODEL1310110001#
name: UDP-Gal Golgi transport via CMP antiport
fast: false
reversible: true
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000185
kinetic law: MODEL1310110001#
type: Reaction

metaR CO2t
product: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from CO2TPr to CO2t NCD
is: SBO:0000185
fast: false
reactant: MODEL1310110001#
reversible: true
name: CO2 transporter via diffusion
type: Reaction
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_1bac504e_d5df_4ac9_b511_14a9328f5b8e
is: P33908
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:4121
name: MAN1A1
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_8916ed5d_7800_4cac_86c8_82bbc29efe33
name: UROD
is: P06132
type: Species
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
is encoded by: hsa:7389

http://identifiers.org/biomodels.db/MODEL1310110001#_e6a2d528_6dbd_422d_9f34_e58c1a65285e
initial concentration: NaN
is: Q99943
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:10554
constant: false
name: AGPAT1
initial amount: NaN

metaR IDOURtly
name: iduronate transport into lysososme
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261,PMID:9852127 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 (for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ renamed from GLCURlt to GLCURtly - NCD added IdoA reaction - NCD
fast: false
product: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
reversible: true

metaR DSAT
type: Reaction
reversible: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
is described by: ECO:0000000
fast: false
name: dihydrosphingosine N-acyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:CoA transfer not explicitly in rxn (accounted for in Rtotal rxn -> ARTF) NJ

metaR FAOXC122C101m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:2-->C10:1)m
type: Reaction

metaM 4abut c
is: C00334
is: SBO:0000247
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:3628
notes: FORMULA: C4H9NO2 CHARGE: 0
initial concentration: 1.0
name: 4-Aminobutanoate
boundary condition: false
constant: false
is: HMDB00112

metaR EX lnlncg LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gamma-linolenic acid exchange
type: Reaction

metaR r0590
kinetic law: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
modifier: MODEL1310110001#
name: ATP:pantetheine-4-phosphate adenylyltransferase Pantothenate and CoA biosynthesis EC:2.7.7.3
type: Reaction
reactant: MODEL1310110001#
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.7.3 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:11994049,PMID:13163064,PMID:15893380 NOTES:

metaM accoa m
is: SBO:0000247
type: Species
name: Acetyl-CoA
is: C00024
is: HMDB01206
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
constant: false
is: CHEBI:57288
boundary condition: false

metaM arachcrn m
is: HMDB06460
type: Species
is: SBO:0000247
initial amount: NaN
name: arachidyl carnitine
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0

metaR RE3524R
is: SBO:0000176
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:9755286 NOTES:
is described by: ECO:0000000
product: MODEL1310110001#
name: RE3524
reversible: true
type: Reaction
kinetic law: MODEL1310110001#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_4d57b04e_e533_456b_9294_5d2ef882144f
boundary condition: true
name: GLUL
initial amount: NaN
is encoded by: hsa:2752
is: SBO:0000252
type: Species
initial concentration: NaN
is: P15104
has only substance units: false
constant: false

metaR ITCOALm
fast: false
reactant: MODEL1310110001#
is described by: ECO:0000212
reversible: true
name: Itaconate--CoA ligase (ADP-forming), mitochondrial
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
is version of: http://identifiers.org/ec-code/6.2.1.5
type: Reaction
is: SBO:0000176
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.2.1.4

metaR TCYNTtm
is: SBO:0000185
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:6351723 NOTES:thiocyanate is found excreted in urine (PMID: 6351723) MM
name: Thiocyanate transport via diffusion (mitochondrial)
reactant: MODEL1310110001#
fast: false
product: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_fba700cc_cb75_4e24_a292_63de761f43a9
initial concentration: NaN
is encoded by: hsa:28976
initial amount: NaN
name: ACAD9
has only substance units: false
boundary condition: true
is: Q9H845
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_aa58113f_1960_46ea_bd8f_294a1ac24128
initial amount: NaN
name: LDHD
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
is encoded by: hsa:197257
type: Species

metaR PAIL HStn
fast: false
is: SBO:0000185
name: phosphatidylinositol nuclear transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:
product: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_a4b120ea_062e_42b4_b05a_4e5532e20cb1
has only substance units: false
type: Species
name: ACAA1
is: Q96CA6
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:30
initial concentration: NaN

metaR FAOXC123C102m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)m
type: Reaction

metaM accoa n
boundary condition: false
is: CHEBI:57288
has only substance units: false
name: acetyl-CoA(4-)
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
is: HMDB01206
initial amount: NaN
type: Species

metaR CSEPASEly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
product: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
reversible: false
name: chondroitin sulfate E proteoglycan protease, lysosome (endosome)
reactant: MODEL1310110001#

metaR EX cdp LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CDP(3-) exchange
type: Reaction

metaR RE1521M
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.16
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is: SBO:0000176
name: RE1521
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
fast: false
reactant: MODEL1310110001#
modifier: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_f85b2f2d_6c6f_46cc_9487_fb6f8e398bf7
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:478
name: ATP1A3
constant: false
has only substance units: false
is: B7Z2T0
is: SBO:0000252

metaR MECOALm
is: SBO:0000176
notes: GENE_ASSOCIATION: (8802.1 and 8803.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.5 Confidence Level: 1 AUTHORS: PMID:13783048 NOTES:NCD
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.5
modifier: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.2.1.4
reactant: MODEL1310110001#
type: Reaction
name: mesaconate--CoA ligase (ADP-forming), mitochondrial
is described by: ECO:0000212

metaM ametam c
notes: FORMULA: C14H24N6O3S CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00683 EHMN_ABBREVIATION: C01137
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB00988
initial amount: NaN
type: Species
is: C01137
initial concentration: 1.0
is: CHEBI:57443
name: S-Adenosylmethioninamine
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_10651737_ef46_4483_a693_bf4f5b8120d9
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
is: Q13423
name: NNT
is encoded by: hsa:23530
initial amount: NaN
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_2cf8091b_b619_4888_ae0a_2d5de4a81cb3
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SULT1A1
type: Species
is encoded by: hsa:6817
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_6b2e7a35_b153_4f16_a084_cc31b5a82495
name: SLC26A6
is: SBO:0000252
constant: false
is encoded by: hsa:65010
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: Q548A7
boundary condition: true

metaM mescon m
is: HMDB00749
notes: FORMULA: C5H4O4 CHARGE: -2 INCHI: InChI=1S/C5H6O4/c1-3(5(8)9)2-4(6)7/h2H,1H3,(H,6,7)(H,8,9)/p-2/b3-2+
is: CHEBI:36986
initial amount: NaN
constant: false
name: Mesaconate
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR CYTK2n
fast: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110001#
modifier: MODEL1310110001#
name: cytidylate kinase (dCMP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_80e29adb_3599_494c_bc65_e7bd9d4c8227
has only substance units: false
name: PPA2
initial concentration: NaN
boundary condition: true
is encoded by: hsa:27068
constant: false
initial amount: NaN
type: Species
is: SBO:0000252

metaR r1807
kinetic law: MODEL1310110001#
reversible: false
fast: false
reactant: MODEL1310110001#
name: Y+LAT2 Utilized transport
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction

metaM 4abut e
type: Species
initial amount: NaN
is: CHEBI:3628
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0
initial concentration: 1.0
boundary condition: false
constant: false
is: HMDB00112
name: 4-Aminobutanoate
is: C00334
is: SBO:0000247

metaM mescoa m
is: SBO:0000247
boundary condition: false
is: CHEBI:27969
name: Mesaconyl-CoA
initial concentration: 1.0
type: Species
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(8-16(35)36)25(40)56-7-6-28-15(34)4-5-29-23(39)20(38)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(37)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h8,11-12,14,18-20,24,37-38H,4-7,9-10H2,1-3H3,(H,28,34)(H,29,39)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/b13-8+/t14-,18-,19-,20+,24-/m1/s1
has only substance units: false
constant: false
is: C06028
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_c6727420_71b9_4c57_ad21_a1181f896e0a
has part: B7Z3U6
initial concentration: NaN
has part: P54709
has only substance units: false
constant: false
type: Species
is encoded by: hsa:476
is: SBO:0000297
name: ATP1A1:ATP1B3
is encoded by: hsa:483
initial amount: NaN
boundary condition: true

metaR HPDCAt
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NJ
reversible: true
name: fatty acid transport via diffusion
kinetic law: MODEL1310110001#
fast: false
is: SBO:0000185
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_915da98b_bc8b_47fe_a51a_3c2a4dfcb1b2
boundary condition: true
name: ADH1A
type: Species
constant: false
is: P07327
is: SBO:0000252
has only substance units: false
initial amount: NaN
is encoded by: hsa:124
initial concentration: NaN

metaR DM oretn n
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: 4-oxo-retonoic acid demand
type: Reaction

metaM HC01496 m
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
constant: false
name: 2-Amino-3-oxoadipate
notes: FORMULA: C6H8NO5 CHARGE: -1 INCHI: InChI=1S/C6H9NO5/c7-5(6(11)12)3(8)1-2-4(9)10/h5H,1-2,7H2,(H,9,10)(H,11,12) EHMN_ABBREVIATION: C05520
is: CHEBI:28095
initial concentration: 1.0
initial amount: NaN

metaR NACHEX3ly
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) or (3074.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
product: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
reversible: false

metaR GALNTg
notes: GENE_ASSOCIATION: (26290.1) or (79695.1) or (2589.1) or (50614.1) or (8693.1) or (55568.2) or (114805.1) or (11226.1) or (117248.1) or (11227.1) or (55568.1) or (2590.1) or (51809.1) or (26290.1) or (79623.1) or (63917.1) or (2591.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.41 Confidence Level: 0 AUTHORS: PMID:10767557,PMID:12417297,PMID:12507512,PMID:12634319,PMID:15147861,PMID:9765313 NOTES:NCD
modifier: MODEL1310110001#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.41
product: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
name: GalNAc transferase, Golgi apparatus
reactant: MODEL1310110001#

metaR EX HC02207 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-c2 exchange
type: Reaction

metaR PMEVKx
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (10654.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.7.4.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
is version of: http://identifiers.org/ec-code/2.7.4.2
name: phosphomevalonate kinase
is: SBO:0000176
type: Reaction
is described by: ECO:0000134
product: MODEL1310110001#
reversible: false

metaM pro D e
is: SBO:0000247
constant: false
boundary condition: false
type: Species
name: D-proline
is: HMDB03411
is: CHEBI:16313
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_42106018_1946_4fee_b5f8_07292daace03
is: SBO:0000252
initial concentration: NaN
type: Species
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
is: P50747
is encoded by: hsa:3141
name: HLCS

metaR FAOXC16BRx
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid activation(C16br)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_09e95feb_9acc_4ccd_a4f5_a1f1b8a2069e
has only substance units: false
constant: false
is encoded by: hsa:84343
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
name: HPS3
is: Q969F9

metaM gdpfuc g
initial amount: NaN
is: HMDB01095
is: CHEBI:57984
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325
type: Species
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
name: GDP-L-fucose(2-)
has only substance units: false

metaM odecrn m
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1
name: octadecenoyl carnitine
is: C00412
constant: false
is: HMDB01114
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:57394
initial concentration: 1.0
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_a8610cb0_aeae_4545_a8c1_5bb12259a35d
type: Species
name: H6PD
has only substance units: false
is: O95479
constant: false
initial amount: NaN
is encoded by: hsa:9563
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_3205a71b_5c30_4fdc_9ab4_57357f2718cd
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000252
name: BTD
boundary condition: true
initial concentration: NaN
is: P43251
is encoded by: hsa:686

metaM ppa c
is: SBO:0000247
boundary condition: false
is: CHEBI:17272
is: HMDB00237
name: propionate
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163

http://identifiers.org/biomodels.db/MODEL1310110001#_adb9f821_a96a_47ce_92d6_5447631c9681
is encoded by: hsa:3658
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
name: IREB2
is: P48200
type: Species
initial concentration: NaN

metaR SUCD1m
name: succinate dehydrogenase
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.5.1
is described by: ECO:0000134
is: SBO:0000176
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) SUBSYSTEM: Citric acid cycle EC Number: 1.3.99.1 Confidence Level: 0 AUTHORS: PMID:6945861 NOTES:NCD. Biochemical, Genetic
reversible: true
product: MODEL1310110001#

metaR EX ala B LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: beta-Alanine exchange
type: Reaction

metaR RE1836X
product: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: (6342.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.154 Confidence Level: 0 AUTHORS: PMID:10706581 NOTES:
name: RE1836
is described by: ECO:0000000
is: SBO:0000176
fast: false
reactant: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.176
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#

metaR MM5cg
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
fast: false
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.113
is: SBO:0000176
product: MODEL1310110001#
modifier: MODEL1310110001#
reversible: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus

metaR FAOXC61m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C6:1)m
type: Reaction

metaR EX 3ddcrn
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxydodecanoyl carnitine
type: Reaction

metaM adrn e
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
type: Species
name: adrenic acid
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB02226
is: CHEBI:53487

http://identifiers.org/biomodels.db/MODEL1310110001#_27899765_d925_4159_bdbb_a6814eb4d6e7
constant: false
boundary condition: true
initial amount: NaN
name: SLC10A1
is: B2RA41
is encoded by: hsa:6554
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaR UPPDC1
notes: GENE_ASSOCIATION: (7389.1) SUBSYSTEM: Heme synthesis EC Number: 4.1.1.37 Confidence Level: 4 AUTHORS: PMID:3015909 NOTES:Acts on a number of porphyrinogens, r0606
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
reversible: false
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/4.1.1.37

metaR GAPD
reversible: true
type: Reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: glyceraldehyde-3-phosphate dehydrogenase
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.2.1.12
fast: false
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.12 Confidence Level: 0 AUTHORS: PMID:10714828 NOTES:SMP. Same reaction as GAPDH, but localied to spermatids. NOTE: I think "glyceroyl" in this and many other reactions should be "glycerol". There are "glyceroyl" compounds, but I don't think that is what is intended here.

metaR r1418
is: SBO:0000176
reactant: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:10938543,PMID:11493685,PMID:12713833,PMID:12747791,PMID:14640555,PMID:17259996,PMID:17504134,PMID:17826101,PMID:7011879,PMID:7672338 NOTES:
product: MODEL1310110001#
is described by: ECO:0000000
reversible: true
name: Carbonic acid hydro-lyase Nitrogen metabolism EC:4.2.1.1

metaR r1809
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#

metaM uri m
boundary condition: false
is: SBO:0000247
is: HMDB00296
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: CHEBI:16704
initial amount: NaN
type: Species
initial concentration: 1.0
name: uridine
constant: false
has only substance units: false

metaR C140CPT1
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of myristoylcarnitine
type: Reaction

metaM acetone e
name: acetone
constant: false
is: HMDB01659
is: CHEBI:15347
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
type: Species
has only substance units: false
is: SBO:0000247

metaR URATEt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110001#
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110001#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110001#
type: Reaction
name: urate export from cytosol

http://identifiers.org/biomodels.db/MODEL1310110001#_9ed75886_2962_4ff9_be99_d9f03515098f
is encoded by: hsa:5138
is: Q8IW54
boundary condition: true
type: Species
has only substance units: false
name: PDE2A
is: SBO:0000252
initial concentration: NaN
constant: false
initial amount: NaN

metaR PTCRTD
product: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 9505881, PMID: 11564949 NOTES:putriscine uptake by the cells via passive diffusion, reported to be more rapid at the basolateral side.
is described by: ECO:0000134
type: Reaction
kinetic law: MODEL1310110001#
name: diffusion of putriscine into the endothelial cells
is: SBO:0000185
reversible: true

metaM pdx5p c
type: Species
initial amount: NaN
constant: false
has only substance units: false
name: Pyridoxine 5'-phosphate
is: CHEBI:58589
notes: FORMULA: C8H10NO6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00459 EHMN_ABBREVIATION: C00627
initial concentration: 1.0
boundary condition: false
is: HMDB01319
is: SBO:0000247
is: C00627

http://identifiers.org/biomodels.db/MODEL1310110001#_2a0a7c3b_247d_4d1f_9d4e_24a2508e20c6
boundary condition: true
has only substance units: false
constant: false
name: TM7SF2
initial concentration: NaN
initial amount: NaN
is: O76062
is: SBO:0000252
type: Species
is encoded by: hsa:7108

metaM pro D c
has only substance units: false
initial amount: NaN
type: Species
is: HMDB03411
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m1/s1
initial concentration: 1.0
boundary condition: false
name: D-proline
is: CHEBI:16313
is: SBO:0000247
constant: false

metaR RTOTALt
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185
type: Reaction
name: RTOTAL transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:

metaR C162ACBP
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxy trans7,10-hexadecadienoylcoa from mitochondria into cytosol
type: Reaction

metaM ksi pre35 g
name: keratan sulfate I biosynthesis, precursor 35
type: Species
has only substance units: false
initial amount: NaN
notes: FORMULA: C241H384N17O205S11X CHARGE: -12
is: SBO:0000247
boundary condition: false
is: CHEBI:28067
constant: false
initial concentration: 1.0

metaR TYROXDAc
modifier: MODEL1310110001#
reversible: false
name: Tyramine:oxygen oxidoreductase(deaminating)(flavin-containing) (cytosol)
reactant: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.6 Confidence Level: 4 AUTHORS: PMID:11336106,PMID:14697899,PMID:8255365 NOTES:SAB also 1.4.3.4
is described by: ECO:0000269
kinetic law: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.4
is: SBO:0000176
product: MODEL1310110001#

metaR PI5P3K
fast: false
product: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.154
name: phosphatidylinositol-5-phosphate 3-kinase
kinetic law: MODEL1310110001#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.7.1.137
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5295.2 and 5290.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.1) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (5291.1 and 8503.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5290.1 and 5295.3) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
is: SBO:0000176
reactant: MODEL1310110001#
modifier: MODEL1310110001#
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.153

metaM ppa e
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00237
has only substance units: false
initial amount: NaN
notes: FORMULA: C3H5O2 CHARGE: -1 INCHI: InChI=1S/C3H6O2/c1-2-3(4)5/h2H2,1H3,(H,4,5)/p-1 HEPATONET_1.0_ABBREVIATION: HC00158 EHMN_ABBREVIATION: C00163
name: propionate
is: SBO:0000247
type: Species
is: CHEBI:17272

metaR LNLNCGCRNt
product: MODEL1310110001#
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
kinetic law: MODEL1310110001#
is: SBO:0000185
fast: false
reversible: false

metaR PRAGSr
is version of: http://identifiers.org/ec-code/2.1.2.2
notes: GENE_ASSOCIATION: (2618.1) or (2618.2) SUBSYSTEM: Purine synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
reversible: true
is: SBO:0000176
reactant: MODEL1310110001#
name: phosphoribosylglycinamide synthase
product: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110001#_c4dc099f_609c_41b8_94f6_665ff98b1a94
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
name: PHGDH
boundary condition: true
is encoded by: hsa:26227
constant: false
is: O43175

metaR GLYC St
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: PMID:9604805 NOTES:
type: Reaction
fast: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: false
name: L-glycerate export
is: SBO:0000185
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_a03ba622_0886_481e_9e4c_9a793cea26d4
has only substance units: false
is: SBO:0000252
is: Q9Y672
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:29929
constant: false
name: ALG6
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_9cf8b4fd_0644_49cd_83fe_9d1e4ea92135
has only substance units: false
constant: false
initial concentration: NaN
name: SLC7A8
is: SBO:0000252
type: Species
is encoded by: hsa:23428
boundary condition: true
initial amount: NaN
is: Q86U05

metaR P450SCC1m
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1525048 NOTES:Acting on paired donors with incorporation of molecular oxygen With a reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
product: MODEL1310110001#
name: cholesterol monooxygenase
is described by: ECO:0000134
is: SBO:0000176
fast: false
reactant: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
reversible: true

metaR r1630
reversible: true
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000

metaM adrn c
initial concentration: 1.0
notes: FORMULA: C22H35O2 CHARGE: -1 INCHI: InChI=1S/C22H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-21H2,1H3,(H,23,24)/b7-6-,10-9-,13-12-,16-15-
constant: false
name: adrenic acid
initial amount: NaN
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB02226
is: CHEBI:53487

metaM lneldccrn c
boundary condition: false
constant: false
notes: FORMULA: C25H45NO4 CHARGE: 0 INCHI: InChI=1/C25H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h9-10,12-13,23H,5-8,11,14-22H2,1-4H3/b10-9+,13-12+
has only substance units: false
type: Species
initial amount: NaN
is: HMDB06461
is: SBO:0000247
name: Linoelaidyl carnitine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_22dd3e48_5b44_45ba_a261_c872bbb464b7
is: P30084
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: ECHS1
is encoded by: hsa:1892
constant: false

metaR 4MPTNLtm
product: MODEL1310110001#
reversible: true
name: 4-methylpentanal transport (mitochondria)
kinetic law: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:8428987 NOTES:
is described by: ECO:0000000
fast: false
reactant: MODEL1310110001#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_3cdc3883_5790_40e9_aa1f_7ee06032b08e
is: SBO:0000252
name: _T83654_1_m
type: Species
initial amount: NaN
is encoded by: hsa:T83654
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaM ctp e
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
name: CTP(4-)
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 INCHI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063
is: CHEBI:37563
initial amount: NaN
constant: false
is: HMDB00082
is: SBO:0000247

metaM HC00250 e
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial concentration: 1.0
name: hydrosulfide
is: CHEBI:29919
initial amount: NaN
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_2b7ae56d_a54a_4cd2_b59c_62cec78dad43
type: Species
name: GPX7
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q96SL4
is encoded by: hsa:2882

metaM ha e
is: SBO:0000247
boundary condition: false
is: CHEBI:16336
initial concentration: 1.0
notes: FORMULA: C28H40N2O22 CHARGE: -2 EHMN_ABBREVIATION: C00518
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: hyaluronan

http://identifiers.org/biomodels.db/MODEL1310110001#_5ce7337c_38a6_4bd7_9258_4b4db27389d1
has only substance units: false
is encoded by: hsa:8526
is: SBO:0000252
is: A1L4Q0
initial concentration: NaN
boundary condition: true
initial amount: NaN
name: DGKE
constant: false
type: Species

metaM ksii core4 pre7 g
is: SBO:0000247
type: Species
constant: false
boundary condition: false
is: CHEBI:58053
notes: FORMULA: C75H121N6O56SX CHARGE: -2
is: C00130
initial concentration: 1.0
is: HMDB00175
initial amount: NaN
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 7

metaM maltpt e
initial amount: NaN
is: http://identifiers.org/pubchem.compound/5141
name: maltopentaose
has only substance units: false
is: SBO:0000247
constant: false
is: C02052
is: HMDB01296
type: Species
notes: FORMULA: C30H52O26 CHARGE: 0 EHMN_ABBREVIATION: CE2835
initial concentration: 1.0
boundary condition: false

metaM uri n
boundary condition: false
constant: false
type: Species
is: HMDB00296
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16704
initial amount: NaN
has only substance units: false
name: uridine
notes: FORMULA: C9H12N2O6 CHARGE: 0 INCHI: InChI=1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299

http://identifiers.org/biomodels.db/MODEL1310110001#_80447ad2_cbde_42b3_a018_0b84d61ab1fb
constant: false
is encoded by: hsa:2984
has only substance units: false
name: GUCY2C
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: P25092
is: SBO:0000252

metaM hs deg1 l
has only substance units: false
is: SBO:0000247
name: heparan sulfate, degradation product 1
is: CHEBI:17180
notes: FORMULA: C79H115N5O99S11 CHARGE: -12
is: HMDB01352
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species

metaM cholcoaone x
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C48H74N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-30,32-34,36,38-40,44,56,58-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/p-4/t24-,25?,26+,27-,28-,29+,30+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01473 EHMN_ABBREVIATION: C05467
is: HMDB06891
constant: false
is: SBO:0000247
name: 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA(4-)
type: Species
is: CHEBI:58507
boundary condition: false

metaR RE0944E
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.1
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.17
fast: false
reversible: true
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
modifier: MODEL1310110001#
type: Reaction
name: RE0944

http://identifiers.org/biomodels.db/MODEL1310110001#_86125aed_777e_4838_88ef_0e5ed8a2fbf4
name: _D29675_1_e
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:D29675
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false

metaM thmpp m
is: CHEBI:45931
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 INCHI: InChI=1S/C12H18N4O7P2S/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21) HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
has only substance units: false
initial concentration: 1.0
name: Thiamine diphosphate
constant: false
is: HMDB01372
boundary condition: false
type: Species

metaM leuktrD4 r
initial concentration: 1.0
boundary condition: false
has only substance units: false
type: Species
is: HMDB03080
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:28666
name: Leukotriene D4
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951

metaM gpi prot hs r
type: Species
is: C00249
name: {[(Prot-PE-Man),(PE)-Man],[PE]}-Man-GlcN-acylPI
boundary condition: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2X CHARGE: 0
is: HMDB00220
is: CHEBI:7896
initial concentration: 1.0
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_191ce5c2_6238_415c_b05a_194dbc7c31a5
type: Species
name: GALK2
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
is: Q01415
has only substance units: false
is encoded by: hsa:2585

metaR GTHP
notes: GENE_ASSOCIATION: (7001.3) or (5052.3) or (2877.1) or (2876.2) or (5052.2) or (2876.1) or (5052.1) or (7001.1) or (2879.1) or (7001.2) SUBSYSTEM: Glutathione metabolism EC Number: 1.11.1.9 Confidence Level: 4 AUTHORS: PMID:15802613,PMID:17015272,PMID:17015273 NOTES:NCD
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.11.1.12
kinetic law: MODEL1310110001#
reversible: true
is version of: http://identifiers.org/ec-code/1.11.1.9
name: glutathione peroxidase
is version of: http://identifiers.org/ec-code/1.11.1.15
product: MODEL1310110001#
is described by: ECO:0000134
type: Reaction
modifier: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_982dee44_d2b0_4f3e_86b7_4d85f4444514
constant: false
is encoded by: hsa:2876
boundary condition: true
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
is: P07203
has only substance units: false
name: GPX1

metaR r0145
kinetic law: MODEL1310110001#
name: L-Arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) Arginine and proline metabolism EC:1.14.13.39
is: SBO:0000176
product: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/1.8.3.1
reactant: MODEL1310110001#
is described by: ECO:0000000
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (6821.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.14.13.39 Confidence Level: 0 AUTHORS: PMID:11125020,PMID:7515853 NOTES:

metaR r1631
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#

metaR S2L2N2M2MASNtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
type: Reaction
name: s2l2n2m2masn transport, extracellular to lysosome
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110001#

metaR M4MPDOL Uter
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
fast: false
product: MODEL1310110001#
name: m4mpdol flippase
reversible: false
reactant: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185

metaM CE1935 e
initial concentration: 1.0
has only substance units: false
type: Species
name: spermine monoaldehyde
is: CHEBI:30623
boundary condition: false
is: HMDB02329
notes: FORMULA: C10H26N3O CHARGE: 3 INCHI: InChI=1/C10H23N3O/c11-5-3-8-12-6-1-2-7-13-9-4-10-14/h10,12-13H,1-9,11H2/p+3 EHMN_ABBREVIATION: CE1935
constant: false
is: SBO:0000247
initial amount: NaN

metaM thf c
name: 5,6,7,8-Tetrahydrofolate
is: CHEBI:57453
is: HMDB01846
initial concentration: 1.0
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
has only substance units: false
is: C00101
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
boundary condition: false

metaM chlstol r
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,10,19-21,23-25,28H,6,8-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01452 EHMN_ABBREVIATION: C05439
initial amount: NaN
initial concentration: 1.0
name: 5alpha-cholesta-7,24-dien-3beta-ol
has only substance units: false
is: SBO:0000247
is: HMDB06842
boundary condition: false
constant: false
type: Species
is: CHEBI:16290

metaR EX 3tetd7ecoacrn
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy tetradecenoyl-7-carnitine
type: Reaction

metaR RE3567C
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.3.9 Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
name: RE3567
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: true
fast: false
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

metaM CE5101 m
type: Species
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
notes: FORMULA: C11H15O16P2R2 CHARGE: -3 EHMN_ABBREVIATION: CE5101
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:57795
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_0407881a_9f48_42ca_a258_314835456688
initial concentration: NaN
constant: false
boundary condition: true
name: NME1
type: Species
is encoded by: hsa:4830
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR GTHO
type: Reaction
modifier: MODEL1310110001#
reversible: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2936.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.8.1.7 Confidence Level: 2 AUTHORS: PMID:10708558 NOTES:NCD, TV This EC (1.6.4.2) is obsolete. The new EC is 1.8.1.7. http://www.genome.ad.jp/dbget-bin/www_bget?ec:1.6.4.2
reactant: MODEL1310110001#
is described by: ECO:0000254
name: glutathione oxidoreductase
fast: false
is version of: http://identifiers.org/ec-code/1.8.1.7

metaR C226COAtx
name: fatty acid intracellular transport
product: MODEL1310110001#
fast: false
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
type: Reaction
reactant: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#

metaR EX CE5786 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin exchange
type: Reaction

metaM apoC Lys btn m
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/7886
boundary condition: false
initial amount: NaN
notes: FORMULA: C16H27N4O3SX CHARGE: 0
is: C05552
is: HMDB03134
is: SBO:0000247
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
initial concentration: 1.0
type: Species

metaR TMDPK
kinetic law: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/2.7.6.2
product: MODEL1310110001#
name: Thiamin pyrophosphokinase (EC 2.7.6.2)
is: SBO:0000176
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (27010.1) SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
modifier: MODEL1310110001#
is described by: ECO:0000269
type: Reaction

metaM arachcrn c
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C27H53NO4 CHARGE: 0 INCHI: InChI=1/C27H53NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h25H,5-24H2,1-4H3
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: HMDB06460
name: arachidyl carnitine

metaM anth c
is: HMDB01123
name: anthranilate
boundary condition: false
constant: false
is: CHEBI:16567
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1 HEPATONET_1.0_ABBREVIATION: HC00107 EHMN_ABBREVIATION: C00108
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species

metaR COQ5m
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:_2.1.1.- IT
reversible: false
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
name: Ubiquinone biosynthesis methyltransferase COQ5
kinetic law: MODEL1310110001#
is: SBO:0000176
fast: false

metaR PTDCACRNCPT2
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.21
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11274214,PMID:1528846,PMID:1988962 NOTES:NJ
name: pentadecanoate transport into the mitochondria
is: SBO:0000176
modifier: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reversible: false
type: Reaction
fast: false
reactant: MODEL1310110001#

metaR r1632
reactant: MODEL1310110001#
product: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
modifier: MODEL1310110001#
type: Reaction
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (57835.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000

metaM 3hodcoa m
is: SBO:0000247
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
boundary condition: false
type: Species
has only substance units: false
constant: false
name: (S)-3-Hydroxyoctadecanoyl-CoA
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355

http://identifiers.org/biomodels.db/MODEL1310110001#_393341e1_f0db_4826_a93c_986c15d30b60
boundary condition: true
is encoded by: hsa:39
constant: false
is: SBO:0000252
name: ACAT2
initial amount: NaN
has only substance units: false
type: Species
is: Q9BWD1
initial concentration: NaN

metaM ade c
notes: FORMULA: C5H5N5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
type: Species
has only substance units: false
name: Adenine
is: C00147
initial concentration: 1.0
constant: false
boundary condition: false
is: HMDB00034
initial amount: NaN
is: CHEBI:16708
is: SBO:0000247

metaR RE3003M
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
is described by: ECO:0000000
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/5.3.3.8
reversible: true
modifier: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
fast: false
name: RE3003
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
reactant: MODEL1310110001#

metaR RE2625M
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176
fast: false
name: RE2625
product: MODEL1310110001#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:

metaR ADRNCRNt
type: Reaction
modifier: MODEL1310110001#
fast: false
is described by: ECO:0000000
product: MODEL1310110001#
reactant: MODEL1310110001#
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) or (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reversible: false
kinetic law: MODEL1310110001#
is: SBO:0000185

metaR r0860
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.1.2.27
is: SBO:0000185
name: Utilized transport
reversible: true
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:1459,PMID:14598172,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110001#
is described by: ECO:0000000
fast: false
product: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction

metaR SARCStm
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
name: Sarcosine transport (mitochondrial)
fast: false
is: SBO:0000185
reversible: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
is described by: ECO:0000000

metaR AG13T9g
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (146712.1) or (79369.1) or (10331.1) or (374907.1) or (10678.2) or (374907.2) or (10678.1) or (11041.1) or (93010.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is described by: ECO:0000000
reversible: false

metaR FAOXC204C205x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C20:5)x
type: Reaction

metaR ALADGLYexR
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000185
name: D-alanine/glycine reversible exchange
is described by: ECO:0000304
reversible: true
fast: false
product: MODEL1310110001#

metaR r1633
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
is: SBO:0000185

metaM C02470 c
is: SBO:0000247
type: Species
is: C02470
name: Xanthurenic acid
is: http://identifiers.org/pubchem.compound/5485
notes: FORMULA: C10H6NO4 CHARGE: -1 INCHI: InChI=1/C10H7NO4/c12-7-3-1-2-5-8(13)4-6(10(14)15)11-9(5)7/h1-4,12H,(H,11,13)(H,14,15) HEPATONET_1.0_ABBREVIATION: HC00945 EHMN_ABBREVIATION: C02470
initial amount: NaN
is: HMDB00881
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false

metaR GLYt7 311 r
reactant: MODEL1310110001#
product: MODEL1310110001#
name: glycine reversible transport via sodium and chloride symport (3:1:1)
notes: GENE_ASSOCIATION: (9152.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
fast: false
is: SBO:0000185
type: Reaction
is described by: ECO:0000006

http://identifiers.org/biomodels.db/MODEL1310110001#_db4e9778_552b_4f23_96a8_9d0c05c13b60
initial concentration: NaN
boundary condition: true
name: SLC2A7
is encoded by: hsa:155184
constant: false
initial amount: NaN
is: Q6PXP3
type: Species
is: SBO:0000252
has only substance units: false

metaM CE2421 m
type: Species
is: HMDB02329
is: SBO:0000247
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-28,32-34,38,47,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE2421
boundary condition: false
name: (3S)-3-hydroxylinoleoyl-CoA
initial amount: NaN
has only substance units: false
is: CHEBI:30623
constant: false
initial concentration: 1.0

metaR VALLAT1tc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of L-Valine by LAT1 in association with 4F2hc, across the apical surface of the memebranes.
type: Reaction

metaR ADPACTD
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport into cytosol (diffusion)
type: Reaction

metaM accoa g
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 INCHI: InChI=1S/C23H38N7O17P3S/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38)/p-4/t13-,16-,17-,18+,22-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB01206
name: acetyl-CoA(4-)
is: CHEBI:57288
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_f13d985b_a845_40a5_8a85_ebe256c2f1cc
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:55276
is: Q96G03
is: SBO:0000252
has only substance units: false
constant: false
name: PGM2

metaR PTDCACRNCPT1
product: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000176
reversible: false
modifier: MODEL1310110001#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (1375.1) or (1375.4) or (1375.3) or (1374.1) or (126129.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:NJ
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.21
name: carnitine fatty-acyl transferase

metaR FORtr
is described by: ECO:0000000
reactant: MODEL1310110001#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110001#
fast: false
reversible: true
product: MODEL1310110001#
name: FOR transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ

metaM adn m
is: CHEBI:16335
type: Species
boundary condition: false
is: HMDB00050
initial concentration: 1.0
notes: FORMULA: C10H13N5O4 CHARGE: 0 INCHI: InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
name: adenosine
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

metaM ksi pre24 g
is: C00130
notes: FORMULA: C191H306N13O158S7X CHARGE: -8
boundary condition: false
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB00175
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 24
constant: false
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110001#_d4691672_a59f_4236_9ce8_b3c512ddf6d8
has only substance units: false
name: PDHA2
boundary condition: true
is: P29803
type: Species
is: SBO:0000252
is encoded by: hsa:5161
initial amount: NaN
constant: false
initial concentration: NaN

metaR NACHEX24ly
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110001#
reversible: false
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110001#
modifier: MODEL1310110001#
product: MODEL1310110001#

metaM odecrn c
is: C00412
initial amount: NaN
is: CHEBI:57394
initial concentration: 1.0
type: Species
name: octadecenoyl carnitine
constant: false
boundary condition: false
is: HMDB01114
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H47NO4 CHARGE: 0 INCHI: InChI=1/C25H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h12-13,23H,5-11,14-22H2,1-4H3/t23-/m0/s1

metaR 34HPLFM
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
name: 3-(4-hydroxyphenyl-)lactate formation
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
product: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaR AG13T13g
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
kinetic law: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false

metaM xoldioloneh c
name: 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one
type: Species
is: HMDB06887
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-18,20-25,29-30H,6-15H2,1-5H3/t17-,18+,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01462 EHMN_ABBREVIATION: C05453
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: CHEBI:2288
is: SBO:0000247
initial concentration: 1.0

metaR r1634
product: MODEL1310110001#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#

metaM acald e
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
name: acetaldehyde
is: HMDB00990
is: CHEBI:15343
type: Species
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084

metaM adrncoa m
initial concentration: 1.0
name: adrenyl coenzyme A
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
type: Species
is: C16170
has only substance units: false
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/47205480

metaM uri c
has only substance units: false
type: Species
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: HMDB00296
boundary condition: false
name: Uridine
initial concentration: 1.0
initial amount: NaN
is: CHEBI:16704
is: SBO:0000247
is: C00299
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_f304aee1_a9e1_4a1f_8243_f207ef2bd18f
name: AMT
constant: false
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is: P48728
has only substance units: false
is: SBO:0000252
is encoded by: hsa:275

http://identifiers.org/biomodels.db/MODEL1310110001#_2bec41d5_f4a3_43e5_b811_f9b2992b28db
is: P08195
boundary condition: true
has only substance units: false
name: SLC3A2
initial concentration: NaN
is encoded by: hsa:6520
initial amount: NaN
is: SBO:0000252
constant: false
type: Species

metaM mi13p c
boundary condition: false
is: SBO:0000247
is: HMDB06234
constant: false
initial amount: NaN
initial concentration: 1.0
is: CHEBI:18225
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16/h1-10H,(H2,11,12,13)(H2,14,15,16)/t1-,2-,3+,4+,5+,6-
name: 1D-myo-Inositol 1,3-bisphosphate
has only substance units: false
type: Species

metaM ade e
has only substance units: false
is: SBO:0000247
boundary condition: false
name: adenine
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H5N5 CHARGE: 0 INCHI: InChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10) HEPATONET_1.0_ABBREVIATION: HC00144 EHMN_ABBREVIATION: C00147
is: CHEBI:16708
constant: false
is: HMDB00034

metaR r0142
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.3.1 Confidence Level: 0 AUTHORS: PMID:12763039,PMID:16475804,PMID:17459792 NOTES:
modifier: MODEL1310110001#
fast: false
reversible: false
name: Sulfite:oxygen oxidoreductase Sulfur metabolism EC:1.8.3.1
is described by: ECO:0000000
product: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.1.5

metaM anth e
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C7H6NO2 CHARGE: -1 INCHI: InChI=1S/C7H7NO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,8H2,(H,9,10)/p-1
is: CHEBI:16567
is: HMDB01123
is: SBO:0000247
name: anthranilate

metaR EX elaid LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: elaidic acid exchange
type: Reaction

metaM docoscoa x
initial concentration: 1.0
notes: FORMULA: C43H74N7O17P3S CHARGE: -4
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
name: docosanoylcoa
constant: false
boundary condition: false
is: HMDB12930

metaM thmpp c
has only substance units: false
is: SBO:0000247
name: Thiamine diphosphate
is: CHEBI:45931
notes: FORMULA: C12H16N4O7P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00071 EHMN_ABBREVIATION: C00068
constant: false
initial amount: NaN
is: HMDB01372
is: C00068
initial concentration: 1.0
boundary condition: false
type: Species

metaR RE3074X
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (11001.1) or (2182.1) or (2181.1) or (2180.1) or (51703.1) or (23305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:11060359,PMID:11356164 NOTES:IT - fixed proton
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110001#
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
name: RE3074
modifier: MODEL1310110001#

metaR r1635
reactant: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
reversible: true
product: MODEL1310110001#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#

metaR N2M2NMASNtly
kinetic law: MODEL1310110001#
reversible: false
reactant: MODEL1310110001#
is described by: ECO:0000000
fast: false
name: n2m2nmasn transport, extracellular to lysosome
type: Reaction
is: SBO:0000185
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110001#_0293bd6a_e794_4856_8818_14b5462c6e28
is encoded by: hsa:5244
is: SBO:0000252
has only substance units: false
constant: false
name: ABCB4
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaR FAOXC2452256x
is version of: http://identifiers.org/ec-code/1.3.3.6
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:5,n-6 -> c22:5, n-6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
type: Reaction
product: MODEL1310110001#
modifier: MODEL1310110001#
reversible: false
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_aacdee93_bcac_4c48_8534_2e9e4ed84500
is encoded by: hsa:6508
boundary condition: true
constant: false
is: P48751
initial concentration: NaN
initial amount: NaN
name: SLC4A3
type: Species
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_2964830a_2593_4dad_93c8_705763513a0c
initial concentration: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:376497
is: SBO:0000252
name: SLC27A1
initial amount: NaN
type: Species

metaR HTDCRNe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-tetradecanoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_d8a7057d_ee1d_4395_b6c8_6136c11b33a7
initial concentration: NaN
is: Q9ULC5
type: Species
boundary condition: true
is encoded by: hsa:51703
constant: false
has only substance units: false
initial amount: NaN
name: ACSL5
is: SBO:0000252

metaR PAPtg
product: MODEL1310110001#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110001#
is: SBO:0000185
name: adenosine 3',5'-bisphosphate Golgi transport
reactant: MODEL1310110001#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_6f395b08_71cc_4d0f_a6e2_4a9cb00419d8
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AI990637
boundary condition: true
name: _AI990637_1_x
has only substance units: false
constant: false
type: Species
is: SBO:0000252

metaM acetone m
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C3H6O CHARGE: 0 INCHI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3 HEPATONET_1.0_ABBREVIATION: HC00193 EHMN_ABBREVIATION: C00207
is: CHEBI:15347
name: acetone
type: Species
is: HMDB01659
has only substance units: false
boundary condition: false

metaM uri e
is: SBO:0000247
has only substance units: false
notes: FORMULA: C9H12N2O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00259 EHMN_ABBREVIATION: C00299
is: HMDB00296
is: CHEBI:16704
boundary condition: false
initial amount: NaN
name: Uridine
type: Species
constant: false
is: C00299
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_5e9086e1_54ea_44f5_8611_6682c4c5b35c
constant: false
has only substance units: false
name: RPN2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6185
type: Species
is: P04844
initial amount: NaN
boundary condition: true

metaR r1636
modifier: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
product: MODEL1310110001#

metaM acald c
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false
name: acetaldehyde
is: HMDB00990
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
is: CHEBI:15343
boundary condition: false
initial concentration: 1.0

metaR EX dgtp LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of dGTP
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_ba657448_62c7_4085_b504_a714385de7ce
has only substance units: false
initial amount: NaN
name: GNPDA1
boundary condition: true
is: P46926
is: SBO:0000252
type: Species
is encoded by: hsa:10007
initial concentration: NaN
constant: false

metaM gchola e
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: HMDB00138
is: SBO:0000247
notes: FORMULA: C26H43NO6 CHARGE: 0
name: glycocholate

metaR EX sph1p LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphinganine 1-phosphate exchange
type: Reaction

metaR SPMS
name: spermidine synthase
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (6723.1) SUBSYSTEM: Urea cycle EC Number: 2.5.1.16 Confidence Level: 4 AUTHORS: PMID:2069720,PMID:8343131 NOTES:
modifier: MODEL1310110001#
reversible: false
product: MODEL1310110001#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.16
reactant: MODEL1310110001#

metaR HMGCOASim
is: SBO:0000176
name: Hydroxymethylglutaryl CoA synthase (ir)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.3.10
modifier: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (3158.1) SUBSYSTEM: Cholesterol metabolism EC Number: 4.1.3.5 Confidence Level: 4 AUTHORS: PMID:7893153 NOTES:NCD New assignment: EC-2.3.3.10 EC-4.1.3.5 (created 1961, deleted 2002). Enzyme Commission mitochondrial enzyme NJ Made irreversible to match KEGG data for S. aureus
reversible: false
reactant: MODEL1310110001#
product: MODEL1310110001#

metaM HC02023 r
has only substance units: false
type: Species
constant: false
name: Cholesterol-ester-ol
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C45H78O2 CHARGE: 0 INCHI: InChI=1S/C45H78O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25-43(46)47-38-30-32-44(5)37(34-38)26-27-39-41-29-28-40(36(4)24-22-23-35(2)3)45(41,6)33-31-42(39)44/h14-15,26,35-36,38-42H,7-13,16-25,27-34H2,1-6H3/b15-14-/t36-,38+,39+,40-,41+,42+,44+,45-/m1/s1
boundary condition: false
is: CHEBI:46898
initial amount: NaN

metaM pyam5p c
is: HMDB01555
is: CHEBI:58451
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: C00647
is: SBO:0000247
type: Species
notes: FORMULA: C8H12N2O5P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00475 EHMN_ABBREVIATION: C00647
name: Pyridoxamine 5'-phosphate
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_3cd394db_132d_442b_888d_3e3b377e25d7
is: Q9Y2A9
type: Species
has only substance units: false
initial concentration: NaN
name: B3GNT3
is: SBO:0000252
boundary condition: true
is encoded by: hsa:10331
initial amount: NaN
constant: false

metaM ksii core2 deg9 l
initial concentration: 1.0
notes: FORMULA: C30H50N3O20X CHARGE: 0
is: CHEBI:12936
initial amount: NaN
type: Species
constant: false
is: SBO:0000247
boundary condition: false
has only substance units: false
is: HMDB00143
name: keratan sulfate II (core 2-linked), degradation product 9

http://identifiers.org/biomodels.db/MODEL1310110001#_71c9cf16_f493_4953_9664_d5420582d6f4
initial amount: NaN
initial concentration: NaN
constant: false
name: _AV717590_1_c
is: SBO:0000252
type: Species
is encoded by: hsa:AV717590
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_36235845_ae06_413c_880b_fa1ebd67f23d
initial concentration: NaN
is: O43674
is encoded by: hsa:4711
name: NDUFB5
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_33049f66_5113_4352_ac97_1960b7bddda0
initial concentration: NaN
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:85365
type: Species
name: ALG2
is: SBO:0000252
initial amount: NaN

metaR G14T7g
is described by: ECO:0000000
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.90
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000176
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
product: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (8704.1) or (8703.1) or (2683.1) or (9334.1) or (8704.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.22

metaR CHSTEROLtrc
type: Reaction
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID: 11229876 NOTES:newly synthesized cholesterol may either be incorporated into membrane or transported out of enterocytes.
is described by: ECO:0000134
reversible: true
is: SBO:0000185
product: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
name: transport of cholesterol into the cytosol

metaR r1637
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110001#
fast: false
reversible: true
type: Reaction
product: MODEL1310110001#
kinetic law: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110001#

metaR FAOXC184C164x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_eee4b96c_e945_4c32_bacc_7b1946fc0534
is: SBO:0000252
constant: false
is: Q96E98
initial concentration: NaN
type: Species
name: RHAG
initial amount: NaN
is encoded by: hsa:6005
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_891835d7_dcaa_46ca_b245_befc68a913ef
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
boundary condition: true
name: ABAT
constant: false
is encoded by: hsa:18

metaM ksii core4 deg1 l
type: Species
is: HMDB00868
constant: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
initial amount: NaN
notes: FORMULA: C78H126N6O64S3X CHARGE: -3
name: keratan sulfate II (core 4-linked), degradation product 1
has only substance units: false
is: CHEBI:57737

metaM gdpfuc c
name: GDP-L-fucose(2-)
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:57984
is: HMDB01095
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C16H23N5O15P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O15P2/c1-4-7(22)9(24)11(26)15(33-4)35-38(30,31)36-37(28,29)32-2-5-8(23)10(25)14(34-5)21-3-18-6-12(21)19-16(17)20-13(6)27/h3-5,7-11,14-15,22-26H,2H2,1H3,(H,28,29)(H,30,31)(H3,17,19,20,27)/p-2/t4-,5+,7+,8+,9+,10+,11-,14+,15?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00275 EHMN_ABBREVIATION: C00325

metaR HEXDICOAACBP
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioyl coa
type: Reaction

metaR FAOXC11C9m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C11-->C9)m
type: Reaction

metaR CHLtm
fast: false
is: SBO:0000185
name: choline transport via diffusion (cytosol to mitochondria)
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10984 NOTES:
reversible: true
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_f453e2ca_20cb_48a9_ac15_c41727d1b2f7
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is encoded by: hsa:M68895
type: Species
name: _M68895_1_c
initial amount: NaN
initial concentration: NaN

metaM docosahexcoa m
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
type: Species
name: 3,7,10,13,16,19-docosahexenoylcoa
notes: FORMULA: C43H62N7O17P3S CHARGE: -4

metaR sink c101coa LPAREN c RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C101COASINK
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_39221ef0_a76a_41ec_b622_efd1f773ad59
constant: false
name: PIK3R1
initial amount: NaN
initial concentration: NaN
is: P27986
boundary condition: true
has only substance units: false
is encoded by: hsa:5295
is: SBO:0000252
type: Species

metaR r0443
reactant: MODEL1310110001#
product: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
name: Palmitoyl-CoA:L-carnitine O-palmitoyltransferase Fatty acid metabolism EC:2.3.1.21
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.1.1.42
reversible: false
notes: GENE_ASSOCIATION: (AI971036.1) or (3417.1) or (3418.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 0 AUTHORS: PMID:1735445,PMID:1988962,PMID:2355017,PMID:6361812,PMID:7892212 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_f4881a90_1948_470e_93be_38efa4f524f9
has only substance units: false
is encoded by: hsa:593
boundary condition: true
initial amount: NaN
is: B4DP47
initial concentration: NaN
name: BCKDHA
constant: false
type: Species
is: SBO:0000252

metaR r1638
kinetic law: MODEL1310110001#
type: Reaction
is: SBO:0000185
modifier: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110001#

metaR RE2999M
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/5.3.3.8
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
fast: false
reactant: MODEL1310110001#
name: RE2999
is described by: ECO:0000000

metaR FAOXC2051843x
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000269
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) or (51.1 and 30.1 and 1962.1) or (3295.1 and 30.1 and 51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
kinetic law: MODEL1310110001#
reversible: false
product: MODEL1310110001#
reactant: MODEL1310110001#
name: Beta oxidation of long chain fatty acid
is version of: http://identifiers.org/ec-code/4.2.1.107
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false

metaR PROt2r
type: Reaction
is described by: ECO:0000304
is: SBO:0000185
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
name: L-proline reversible transport via proton symport
reversible: true
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:NCD

metaR RETNt
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
reversible: true
fast: false
name: retinoic acid transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:8630327 NOTES:IT
product: MODEL1310110001#
type: Reaction

metaM ddcacoa m
is: CHEBI:57375
is: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB03571
initial amount: NaN
is: SBO:0000247
constant: false
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_436f2c96_8e8e_44ff_a958_4aac1e2efb4f
boundary condition: true
constant: false
name: SLC13A5
initial concentration: NaN
has only substance units: false
initial amount: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:284111
is: Q86YT5

metaR C16DCe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Hexadecanedioic acid mono-L-carnitine ester into extra cellular space
type: Reaction

metaM uacgam c
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
initial concentration: 1.0
initial amount: NaN
type: Species
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
constant: false
boundary condition: false
has only substance units: false
is: HMDB00290
is: CHEBI:57705
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_5ae57002_d18d_4cc1_8ef2_3017318ab4f8
initial amount: NaN
boundary condition: true
is encoded by: hsa:728441
has only substance units: false
name: GGT2
initial concentration: NaN
is: SBO:0000252
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_517c7a22_ac18_4212_beee_8e6274ccc413
boundary condition: true
is encoded by: hsa:377841
constant: false
is: Q5MY95
is: SBO:0000252
name: ENTPD8
initial concentration: NaN
initial amount: NaN
type: Species
has only substance units: false

metaR PI345P3P
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reversible: false
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.67
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (5728.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.67 Confidence Level: 4 AUTHORS: PMID:11463863 NOTES:NCD
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_7f8617ef_49af_4856_b81e_b8decbe9f40e
type: Species
constant: false
initial concentration: NaN
is: SBO:0000297
is encoded by: hsa:3295
initial amount: NaN
has part: E9PB82
has only substance units: false
boundary condition: true
name: ACAA1:HSD17B4:ACOX1

metaR MANter
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
reactant: MODEL1310110001#
is: SBO:0000185
type: Reaction
name: mannose efflux from endoplasmic reticulum
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reversible: false
product: MODEL1310110001#

metaR PDE4
fast: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.4.17
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.4.35
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (5139.1) or (5146.1) or (5152.17) or (50940.1) or (5152.6) or (5136.1) or (5152.11) or (5152.2) or (8654.2) or (10846.1) or (5152.10) or (5145.1 and 5158.1 and 5149.1) or (5140.1) or (5152.12) or (5152.15) or (5137.1) or (5136.2) or (5138.1) or (5152.5) or (5153.1) or (5152.20) or (5152.19) or (5152.16) or (8654.3) or (5152.14) or (5152.13) or (5152.7) or (5152.3) or (5140.2) or (8654.1) or (5152.18) or (5145.1 and 5146.1 and 5158.1 and 5147.1 and 5148.1) or (5152.4) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10952971,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12565835,PMID:14527714,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8786098,PMID:8884271,PMID:9210593,PMID:9419816,PMID:9624146,PMID:9716380 NOTES:NCD
product: MODEL1310110001#
name: 3',5'-cyclic-nucleotide phosphodiesterase
type: Reaction
is: SBO:0000176
modifier: MODEL1310110001#
reversible: false

metaR EX gluala LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5-L-Glutamyl-L-alanine exchange
type: Reaction

metaM 3thexddcoa m
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C37H58N7O18P3S CHARGE: -4
has only substance units: false
is: HMDB02014
type: Species
name: 3-hydroxy trans7,10-hexadecadienoylcoa

http://identifiers.org/biomodels.db/MODEL1310110001#_306d83d1_6734_4f89_b238_507948f7c20b
type: Species
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8781
has only substance units: false
constant: false
boundary condition: true
name: _8781_1_c

metaM n2m2nmn l
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)
type: Species
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00742
notes: FORMULA: C50H84N4O36 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: CHEBI:17588
boundary condition: false

metaR r1639
fast: false
kinetic law: MODEL1310110001#
reversible: true
type: Reaction
product: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR HAtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
type: Reaction
product: MODEL1310110001#
fast: false
reversible: false
is described by: ECO:0000000
name: hyaluronan transport, extracellular to lysosome
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185

metaR r0726
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.1.33
kinetic law: MODEL1310110001#
type: Reaction
is: SBO:0000176
name: (S)-Hydroxydecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
reversible: true
fast: false
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
reactant: MODEL1310110001#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_e3c91720_752c_4114_b500_266b8345f979
initial concentration: NaN
boundary condition: true
is: SBO:0000252
constant: false
is encoded by: hsa:10723
initial amount: NaN
has only substance units: false
is: Q9Y666
name: SLC12A7
type: Species

metaR C16DCc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexadecanedioylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_a684123c_b4a8_40ad_ad0e_a054c1f55bcc
is: SBO:0000297
is encoded by: hsa:5295
boundary condition: true
type: Species
has part: P27986
has only substance units: false
initial amount: NaN
constant: false
initial concentration: NaN
name: PIK3CA:PIK3R1

metaR CSNAT2m
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:3759988 NOTES:TDV
product: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
type: Reaction
name: carnitine O-aceyltransferase, mitochondrial
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.7
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_4172bc96_9407_44e5_8a7a_696c9073944b
is: SBO:0000252
is encoded by: hsa:622
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is: Q02338
boundary condition: true
name: BDH1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_268f0418_495c_4550_986a_810a39b1ac4a
is: SBO:0000252
is: Q9UFY1
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5335
name: PLCG1
initial amount: NaN
boundary condition: true
constant: false
type: Species

metaR LNLCt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
name: Linoleic acid (n-C18:2) transport in via diffusion
product: MODEL1310110001#
is: SBO:0000185
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
fast: false
reversible: true

metaM adrncoa c
initial concentration: 1.0
boundary condition: false
is: http://identifiers.org/pubchem.compound/47205480
has only substance units: false
type: Species
initial amount: NaN
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
is: C16170
constant: false
name: adrenyl coenzyme A
is: SBO:0000247

metaR FAOXC12DCx
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of dodecanedioyl carnitine
type: Reaction

metaR r1527
notes: GENE_ASSOCIATION: (AI024818.1) or (AI091231.1) or (AI480132.1) or (AI972237.1) or (AL050025.1) or (759.1) or (771.1) or (377677.1) or (23632.1) or (760.1) or (761.1) or (762.1) or (763.1) or (11238.1) or (765.1) or (766.1) or (767.1) or (768.1) or (8883.1) or (R51273.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:16858612 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.1
fast: false
is: SBO:0000185
type: Reaction
reversible: false
name: ATP-binding Cassette (ABC) TCDB:3.A.1.211.1
modifier: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#

metaM adn e
initial amount: NaN
name: Adenosine
constant: false
is: CHEBI:16335
type: Species
is: C00212
is: HMDB00050
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00196 EHMN_ABBREVIATION: C00212
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaR IMPC
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 3.5.4.10 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
is version of: http://identifiers.org/ec-code/2.1.2.3
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110001#
kinetic law: MODEL1310110001#
name: IMP cyclohydrolase
modifier: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_6c4cac67_8768_43af_a0a3_c509b01de332
initial amount: NaN
type: Species
name: ADH7
constant: false
is encoded by: hsa:131
is: P40394
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252

metaR FAOXC2051843m
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox, 1 degree loss of sat -> no fad oxidation peroxisomal (very long chain FA) c20:5,n-3 -> c18:4, n-3 - final '3' in abbreviation indicates omega3 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110001#
reversible: false
kinetic law: MODEL1310110001#
type: Reaction
name: Beta oxidation of fatty acid
reactant: MODEL1310110001#
is described by: ECO:0000000
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR MI134P4P
reactant: MODEL1310110001#
is: SBO:0000176
reversible: false
product: MODEL1310110001#
name: inositol-1,3,4-trisphosphate 4-phosphatase
kinetic law: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110001#_ccb20c43_3f3d_435c_a7cb_45202ac388e9
has only substance units: false
is: P24539
is: SBO:0000252
name: ATP5F1
constant: false
type: Species
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:515

metaR FACOAL160i
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110001#
reversible: false
kinetic law: MODEL1310110001#
is described by: ECO:0000269
reactant: MODEL1310110001#
is: SBO:0000176
fast: false
modifier: MODEL1310110001#
type: Reaction
name: C160 fatty acid activation
notes: GENE_ASSOCIATION: (2181.2) or (22305.2) or (51703.1) or (22305.1) or (2180.1) or (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:1531127 NOTES:TV catalyzed by acyl-CoA synthetases

metaM thf m
initial concentration: 1.0
is: C00101
is: SBO:0000247
is: HMDB01846
initial amount: NaN
constant: false
notes: FORMULA: C19H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00102 EHMN_ABBREVIATION: C00101
boundary condition: false
type: Species
is: CHEBI:57453
has only substance units: false
name: 5,6,7,8-Tetrahydrofolate

http://identifiers.org/biomodels.db/MODEL1310110001#_cc69f440_2e3f_4035_8c30_e51122374f6c
is encoded by: hsa:5297
constant: false
is: B4DYG5
type: Species
name: PI4KA
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR CSPG Etly
product: MODEL1310110001#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110001#
reversible: false
is: SBO:0000185
name: chondroitin sulfate E transport, extracellular to lysosome
is described by: ECO:0000000
kinetic law: MODEL1310110001#

metaR r0724
name: Decanoyl-CoA:acetyl-CoA C-acyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
reversible: true
modifier: MODEL1310110001#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (AI924226.1) or (53354.1) or (80025.1) or (79646.1) or (55229.1) or (100128062.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:1679347,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.33
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_61fb791a_e8df_4d92_a017_ffe67ffa582b
boundary condition: true
initial amount: NaN
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
is encoded by: hsa:56901
constant: false
is: Q9NRX3
name: NDUFA4L2

http://identifiers.org/biomodels.db/MODEL1310110001#_ffd1ebd2_6c40_4c3a_80d5_fe194596cad7
boundary condition: true
constant: false
type: Species
is encoded by: hsa:5740
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PTGIS
is: Q16647
is: SBO:0000252

metaM hs deg8 l
is: CHEBI:16126
notes: FORMULA: C69H100N4O81S8 CHARGE: -10
constant: false
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
name: heparan sulfate, degradation product 8
initial amount: NaN
is: SBO:0000247

metaR HSD17B4x
fast: false
product: MODEL1310110001#
reversible: false
name: hydroxysteroid (17-beta) dehydrogenase 4
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 4 AUTHORS: NOTES:see Russell bile acid synthesis review paper in human recon citation db adamanski et al Steroids (1997) 62:159 notes cofactor NADP/NADPH use
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
is described by: ECO:0000269
is: SBO:0000176

metaM dmnoncrn m
name: 4,8 dimethylnonanoyl carnitine
has only substance units: false
constant: false
is: HMDB06202
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
notes: FORMULA: C18H37NO4 CHARGE: 0 INCHI: InChI=1/C18H35NO4/c1-14(2)8-7-9-15(3)10-11-18(22)23-16(12-17(20)21)13-19(4,5)6/h14-16H,7-13H2,1-6H3
is: SBO:0000247

metaR EX pan4p LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for pan4p
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_7e45fb71_23e3_4abf_ac8a_fbc193eb9dec
is: SBO:0000252
initial concentration: NaN
is: P21912
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:6390
type: Species
name: SDHB
initial amount: NaN

metaR IMPD
reversible: false
name: IMP dehydrogenase
reactant: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3614.1) or (3615.1) or (3614.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.1.1.205 Confidence Level: 4 AUTHORS: PMID:16464785 NOTES:
is described by: ECO:0000134
modifier: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.205
fast: false

metaM uacgam g
boundary condition: false
constant: false
is: CHEBI:57705
initial amount: NaN
name: UDP-N-acetyl-alpha-D-glucosamine(2-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11-,12-,13-,14-,15-,16-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00050 EHMN_ABBREVIATION: C00043
is: SBO:0000247
is: HMDB00290
type: Species

metaR RE2625C
is described by: ECO:0000000
reactant: MODEL1310110001#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
product: MODEL1310110001#
name: RE2625
is: SBO:0000176
kinetic law: MODEL1310110001#
reversible: true

metaM acald m
name: acetaldehyde
notes: FORMULA: C2H4O CHARGE: 0 INCHI: InChI=1S/C2H4O/c1-2-3/h2H,1H3 HEPATONET_1.0_ABBREVIATION: HC00087 EHMN_ABBREVIATION: C00084
type: Species
boundary condition: false
is: CHEBI:15343
is: SBO:0000247
initial amount: NaN
is: HMDB00990
constant: false
initial concentration: 1.0
has only substance units: false

metaR ACNAMlt
notes: GENE_ASSOCIATION: (26503.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 4 AUTHORS: PMID:10581036,PMID:2768261 NOTES:H symport into lysososome. See PMID: 2768261 and PMID: 10581036 ( for human evidence). Sialic acid storage disorders (due to transporter mutations) require import and export e.g. PMID: 2768266 NJ
name: N-acetylneuraminate transport into lysososme
product: MODEL1310110001#
reversible: true
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000185

metaR RE1709N
modifier: MODEL1310110001#
product: MODEL1310110001#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
name: RE1709
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
reactant: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110001#

metaR KSII CORE4t
product: MODEL1310110001#
reversible: false
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
kinetic law: MODEL1310110001#
name: keratan sulfate II (core4) transport, golgi to extracellular
is described by: ECO:0000000

metaR EX gthrd LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Reduced glutathione exchange
type: Reaction

metaM cs a deg5 l
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C23H36O24S CHARGE: -2
has only substance units: false
initial amount: NaN
is: CHEBI:15936
is: SBO:0000247
type: Species
constant: false
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 5

metaR TYMSULT
is: SBO:0000176
name: Tyramine Sulfotransferase
reversible: false
reactant: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (6818.3) or (6818.1) or (6817.4) or (6817.1) or (6817.3) or (6818.2) or (6817.2) or (6817.5) SUBSYSTEM: Tyrosine metabolism EC Number: 2.8.2.1 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:15293241 NOTES:TV/RS (6/14/05)
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.2.1
fast: false
type: Reaction
kinetic law: MODEL1310110001#

metaR MGSA
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate metabolism EC Number: 4.2.3.3 Confidence Level: 4 AUTHORS: PMID:1537826,PMID:16037240,PMID:8853285 NOTES:Previously EC 4.2.99.11 this rxn represents the enzymatic conversion or non-enzymatic fragmentation of dhap to mthgxl - NCD
is described by: ECO:0000000
reactant: MODEL1310110001#
type: Reaction
name: methylglyoxal synthase
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000176
reversible: false

metaR NOt
is: SBO:0000185
type: Reaction
product: MODEL1310110001#
reversible: true
fast: false
kinetic law: MODEL1310110001#
name: NO transport (diffusion)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:IT (06-16-04)
is described by: ECO:0000000
reactant: MODEL1310110001#

metaR PAPStg
product: MODEL1310110001#
name: 3'-Phosphoadenylyl sufate Golgi transport
notes: GENE_ASSOCIATION: (347734.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:12716889 NOTES:NCD
reactant: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110001#
reversible: true
is described by: ECO:0000269

metaR EX CE2839 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltodecaose exchange
type: Reaction

metaR FAOXC81C61m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8:1-->C6:1)m
type: Reaction

metaR ABTArm
modifier: MODEL1310110001#
reactant: MODEL1310110001#
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
fast: false
reversible: true
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Glutamate metabolism EC Number: 2.6.19.4 Confidence Level: 4 AUTHORS: PMID:10407778,PMID:7721088 NOTES:kh 1/6/03
is version of: http://identifiers.org/ec-code/2.6.1.19
product: MODEL1310110001#
is: SBO:0000176

metaR r0722
reactant: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
product: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (5805.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
is: SBO:0000176
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.35 EC:1.1.1.211
is version of: http://identifiers.org/ec-code/4.2.3.12
reversible: true
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_a7259e75_e735_45e3_8e73_b17b4847a959
name: PLCD1
initial concentration: NaN
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5333
type: Species
is: P51178
has only substance units: false
constant: false

metaR r0149
fast: false
reactant: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.14.13.39
type: Reaction
name: CTP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is described by: ECO:0000000
product: MODEL1310110001#

metaM ttdcrn m
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
type: Species
is: HMDB05066
constant: false
is: http://identifiers.org/pubchem.compound/3413344
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: tetradecanoyl carnitine
boundary condition: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_e75a9194_6e75_44a1_91ff_4edcedc74e0f
name: SLCO1B1
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is: Q9Y6L6
initial amount: NaN
is encoded by: hsa:10599
boundary condition: true
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_44798a75_859a_4afd_adae_66e34a34c84a
initial concentration: NaN
boundary condition: true
type: Species
is: P30043
is: SBO:0000252
constant: false
is encoded by: hsa:645
name: BLVRB
has only substance units: false
initial amount: NaN

metaM homoval m
name: Homovanillate
is: CHEBI:545959
initial concentration: 1.0
initial amount: NaN
constant: false
boundary condition: false
is: HMDB00118
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c1-13-8-4-6(5-9(11)12)2-3-7(8)10/h2-4,10H,5H2,1H3,(H,11,12) HEPATONET_1.0_ABBREVIATION: HC01519 EHMN_ABBREVIATION: C05582
has only substance units: false
is: SBO:0000247
type: Species

metaM hs deg4 l
is: CHEBI:16126
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
notes: FORMULA: C73H104N4O92S10 CHARGE: -12
constant: false
initial amount: NaN
name: heparan sulfate, degradation product 4
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_f480c993_b1fc_4f3a_a7bf_3d114050213e
boundary condition: true
constant: false
type: Species
is: Q92535
initial amount: NaN
name: PIGC
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5279
is: SBO:0000252

metaR FAOXC184C164m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:4)m
type: Reaction

metaM ddcacoa c
constant: false
initial amount: NaN
notes: FORMULA: C33H54N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00850 EHMN_ABBREVIATION: C01832
name: Dodecanoyl-CoA (n-C12:0CoA)
is: CHEBI:57375
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB03571
is: C01832
type: Species

metaR GDPFUCtg
product: MODEL1310110001#
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
type: Reaction
reactant: MODEL1310110001#
name: GDPFuc Golgi transport via CMP antiport
is described by: ECO:0000269
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (55343.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11326279,PMID:11326280 NOTES:NCD

metaM dd3coa x
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
name: 3-dodecenoylcoa
is: HMDB04257

metaM dgsn c
initial amount: NaN
type: Species
is: CHEBI:17172
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: C00330
is: HMDB00085
initial concentration: 1.0
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
name: Deoxyguanosine

metaR r1966
reactant: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000
fast: false
product: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Y+LAT2 Utilized transport
reversible: false

metaR r0723
kinetic law: MODEL1310110001#
is described by: ECO:0000000
name: (S)-3-Hydroxydodecanoyl-CoA:NAD+ oxidoreductase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:1.1.1.211 EC:1.1.1.35
fast: false
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10231530,PMID:10329704,PMID:1550553,PMID:1651711,PMID:7150615,PMID:8188243,PMID:8687463,PMID:9553139 NOTES:
type: Reaction
is: SBO:0000176
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.41
reactant: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.85

metaR NDPK10
kinetic law: MODEL1310110001#
name: nucleoside-diphosphate kinase (ATP:dIDP)
is described by: ECO:0000134
product: MODEL1310110001#
reversible: true
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
modifier: MODEL1310110001#
reactant: MODEL1310110001#
fast: false

metaR C10CRNe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of decanoyl carnitine into extra cellular space
type: Reaction

metaR UROLACer
reactant: MODEL1310110001#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.19 Confidence Level: 1 AUTHORS: PMID:13587494 NOTES:NCD
kinetic law: MODEL1310110001#
fast: false
reversible: true
name: uronolactonase, endoplasmic reticulum
product: MODEL1310110001#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_364578a7_42e1_49fa_bf3c_35fb98569f1b
is encoded by: hsa:271
name: AMPD2
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
is: B2RB47
constant: false
boundary condition: true

metaM gacpail hs c
is: SBO:0000247
boundary condition: false
name: glucosaminyl-acylphosphatidylinositol
initial amount: NaN
notes: FORMULA: C31H58NO14PFULLRCO2FULLR2CO2 CHARGE: 0
is: C00092
constant: false
is: HMDB01401
type: Species
has only substance units: false
initial concentration: 1.0
is: CHEBI:61548

metaR CLFORtex
name: chloride transport via formate countertransport
kinetic law: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (5172.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12759755 NOTES:SAB
reversible: false
is: SBO:0000185
modifier: MODEL1310110001#
is described by: ECO:0000304
type: Reaction
fast: false
reactant: MODEL1310110001#

metaR GLCt4
is described by: ECO:0000269
reactant: MODEL1310110001#
is: SBO:0000185
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (200010.1) or (159963.1) or (6526.1) or (125206.1) or (6524.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11133510,PMID:12436245,PMID:12748858,PMID:1372904,PMID:1415574,PMID:15546855,PMID:7537337,PMID:7789985,PMID:8282810 NOTES:NCD
name: glucose transport via sodium symport
modifier: MODEL1310110001#
reversible: true
product: MODEL1310110001#
fast: false
type: Reaction

metaR NDP10ex
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:IT
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reversible: false
name: nucleoside-diphosphatase (IDP), extracellular

http://identifiers.org/biomodels.db/MODEL1310110001#_134848c8_8f76_49c3_ab81_729ad4273ec8
is: SBO:0000252
is: Q9NVE7
type: Species
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:55229
has only substance units: false
initial concentration: NaN
name: PANK4

metaR NACHEX8ly
reversible: false
kinetic law: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
modifier: MODEL1310110001#
name: beta-N-acetylhexosaminidase, lysosomal
is: SBO:0000176
reactant: MODEL1310110001#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.52
fast: false
product: MODEL1310110001#

metaR EX 5adtststerone LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone exchange
type: Reaction

metaR FAOXC204
reversible: false
fast: false
is described by: ECO:0000269
modifier: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.99.3
type: Reaction
name: Beta oxidation of long chain fatty acid

http://identifiers.org/biomodels.db/MODEL1310110001#_67f7be7f_81d1_460a_b67d_31d5de2144ba
is: Q96CA6
type: Species
constant: false
boundary condition: true
has only substance units: false
name: ACAA1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:30

metaR G6PDH2rer
is: SBO:0000176
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:NCD
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
reversible: true
reactant: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.47
is described by: ECO:0000269

metaM ksi deg11 l
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00143
name: keratan sulfate I, degradation product 11
type: Species
boundary condition: false
notes: FORMULA: C180H289N12O158S9 CHARGE: -9
is: CHEBI:12936
initial amount: NaN
is: SBO:0000247

metaM dcholcoa c
initial concentration: 1.0
initial amount: NaN
name: chenodeoxycholoyl coenzyme a
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
boundary condition: false
type: Species
is: HMDB06292
constant: false
is: CHEBI:28701
is: SBO:0000247
has only substance units: false

metaM accoa c
name: Acetyl-CoA
initial concentration: 1.0
type: Species
is: C00024
is: SBO:0000247
is: HMDB01206
notes: FORMULA: C23H34N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00033 EHMN_ABBREVIATION: C00024
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:57288
boundary condition: false

metaM HC01406 m
has only substance units: false
boundary condition: false
constant: false
is: CHEBI:28264
initial concentration: 1.0
name: 3-Oxooctanoyl-CoA
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C29H44N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H48N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-16,18,22-24,28,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t18-,22-,23-,24+,28-/m1/s1 EHMN_ABBREVIATION: C05267

metaM octd11ecoa c
type: Species
constant: false
name: 11-octadecenoylcoa
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280771
notes: FORMULA: C39H64N7O17P3S CHARGE: -4
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_43122436_45bf_4935_98f4_c1cfe8de5f0a
is encoded by: hsa:6482
boundary condition: true
name: ST3GAL1
is: SBO:0000252
is: Q11201
initial amount: NaN
constant: false
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_1e942feb_a0b8_4775_8006_4fec8f0627cf
initial concentration: NaN
name: PTDSS2
boundary condition: true
initial amount: NaN
has only substance units: false
is encoded by: hsa:81490
is: SBO:0000252
type: Species
is: Q9BVG9
constant: false

metaM dgsn e
is: CHEBI:17172
is: SBO:0000247
notes: FORMULA: C10H13N5O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00280 EHMN_ABBREVIATION: C00330
is: C00330
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
name: Deoxyguanosine
is: HMDB00085
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_4347c235_9669_4b68_a6d8_f9099abbdf80
name: COX1
type: Species
is: Q7GXY8
boundary condition: true
initial amount: NaN
is encoded by: hsa:4512
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR r2139
type: Reaction
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
reactant: MODEL1310110001#
fast: false
product: MODEL1310110001#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
is: SBO:0000185

metaR GALt1r
is: SBO:0000185
name: galactose transport (uniport)
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860996,PMID:11247674,PMID:11592815,PMID:11882499,PMID:12135767,PMID:12750891,PMID:1701966,PMID:2182619,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:NCD
modifier: MODEL1310110001#
is described by: ECO:0000269
product: MODEL1310110001#
type: Reaction

metaM L2aadp m
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
has only substance units: false
name: L-2-aminoadipate(1-)
is: HMDB00510
type: Species
constant: false
is: SBO:0000247
is: CHEBI:58672

metaM dpcoa e
has only substance units: false
is: SBO:0000247
name: Dephospho-CoA
constant: false
boundary condition: false
is: CHEBI:57328
initial concentration: 1.0
is: C00882
type: Species
notes: FORMULA: C21H33N7O13P2S CHARGE: -2
initial amount: NaN
is: HMDB01373

metaM 2amac c
boundary condition: false
constant: false
is: CHEBI:17123
notes: FORMULA: C3H5NO2 CHARGE: 0 INCHI: InChI=1S/C3H5NO2/c1-2(4)3(5)6/h1,4H2,(H,5,6) HEPATONET_1.0_ABBREVIATION: HC00906 EHMN_ABBREVIATION: C02218
is: SBO:0000247
has only substance units: false
type: Species
is: HMDB03609
name: 2-aminoacrylic acid
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_3b358aab_175a_44bb_93e9_73ef33826c41
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:89874
name: SLC25A21
is: G3V4L5
constant: false

metaR CITtam
is: SBO:0000185
type: Reaction
reversible: true
fast: false
name: citrate transport, mitochondrial
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:antiport with malate IF
reactant: MODEL1310110001#
is described by: ECO:0000269
product: MODEL1310110001#

metaR KSIt
is: SBO:0000185
fast: false
kinetic law: MODEL1310110001#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is described by: ECO:0000000
name: keratan sulfate I transport, golgi to extracellular
type: Reaction
product: MODEL1310110001#
reactant: MODEL1310110001#

metaR PGDI
is described by: ECO:0000269
reactant: MODEL1310110001#
fast: false
reversible: true
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (5730.1) or (27306.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.2 Confidence Level: 4 AUTHORS: PMID:9065498,PMID:9353279 NOTES:noted on RER, but also cytoplasmic structures NJ
product: MODEL1310110001#
name: Prostaglandin-H2 D-isomerase [Precursor]
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/5.3.99.2
is version of: http://identifiers.org/ec-code/2.5.1.18

http://identifiers.org/biomodels.db/MODEL1310110001#_28c02267_75f5_4aed_8c27_b6cbb449db5c
is: SBO:0000252
name: ABCA1
has only substance units: false
is: O95477
type: Species
is encoded by: hsa:19
boundary condition: true
initial amount: NaN
constant: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_e146a3d0_0505_4810_a027_e8b2ab545572
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
name: CA8
constant: false
is: P35219
type: Species
initial amount: NaN
is encoded by: hsa:767

http://identifiers.org/biomodels.db/MODEL1310110001#_f8cdeba2_49fd_4807_8a18_98eaee72e731
constant: false
is: SBO:0000252
name: SLC25A26
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:115286
boundary condition: true
has only substance units: false

metaM ksii core2 deg2 l
is: CHEBI:12936
constant: false
boundary condition: false
is: HMDB00143
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C70H114N5O56S2X CHARGE: -2
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 2

metaM leuktrD4 e
has only substance units: false
is: HMDB03080
name: Leukotriene D4
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: CHEBI:28666
initial amount: NaN

metaR AHCYStd
is: SBO:0000185
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
reversible: true
name: diffusion of S-Adenosyl-L-homocysteine
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID: 8283303. NOTES:
product: MODEL1310110001#
fast: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_48cb6ddd_4199_4379_a2b9_469619ff0d70
name: PIGA
initial amount: NaN
initial concentration: NaN
is: B3KUV7
type: Species
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5277

http://identifiers.org/biomodels.db/MODEL1310110001#_e772c076_8fcc_4a74_8f1f_f7b5a6a117bb
initial concentration: NaN
is encoded by: hsa:11112
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
constant: false
name: HIBADH
is: P31937

metaR GBAl
reactant: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: false
product: MODEL1310110001#
is: SBO:0000176
name: Glucosylceramidase
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.45
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (2629.4) or (2629.1) or (2629.3) or (2629.2) or (2629.5) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.45 Confidence Level: 4 AUTHORS: PMID:11933202,PMID:12667141 NOTES:NJ

metaR TRDRm
reversible: false
is version of: http://identifiers.org/ec-code/1.8.1.9
type: Reaction
fast: false
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (114112.1) or (10587.1) or (10587.3) or (10587.2) SUBSYSTEM: Nucleotide interconversion EC Number: 1.8.1.9 Confidence Level: 4 AUTHORS: PMID:10215850,PMID:11259642,PMID:12705894 NOTES:NCD
reactant: MODEL1310110001#
name: thioredoxin reductase (NADPH)
is described by: ECO:0000269

metaR S6TASE17ly
fast: false
type: Reaction
product: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
name: N-acetylglucosamine-6-sulfatase, lysosomal
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_8d47817a_106a_4b6d_82df_dc8d9afdff75
has only substance units: false
is: P28332
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:130
constant: false
type: Species
boundary condition: true
name: ADH6

metaM lnlncgcoa r
is: HMDB06368
initial concentration: 1.0
name: gamma-linolenoyl-CoA(4-)
initial amount: NaN
constant: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
boundary condition: false
type: Species
is: CHEBI:57363

metaR GLYt7 211 r
name: glycine reversible transport via sodium and chloride symport (2:1:1)
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (6536.1) or (6536.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
reactant: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110001#
reversible: true
is: SBO:0000185

metaR C3STDH1Pr
product: MODEL1310110001#
fast: false
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000134
name: C-3 sterol dehydrogenase (4-methylzymosterol)
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.170
reversible: false
notes: GENE_ASSOCIATION: (50814.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10710235,PMID:14506130 NOTES:NCD ER version NJ

metaM m7mpdol U r
has only substance units: false
notes: FORMULA: C1665H2740N20O570P20 CHARGE: -20
boundary condition: false
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:37636

metaR PSP L
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.3.3
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8781.1) or (5723.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 3.1.3.3 Confidence Level: 4 AUTHORS: PMID:9188776,PMID:9573387 NOTES:
modifier: MODEL1310110001#
is: SBO:0000176
reversible: false
type: Reaction
name: phosphoserine phosphatase (L-serine)

metaR DOLGLCP Uter
reversible: false
type: Reaction
name: Dolichyl beta-D-glucosyl phosphate flippase (uterus)
fast: false
is: SBO:0000185
kinetic law: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
reactant: MODEL1310110001#
product: MODEL1310110001#

metaR FATP2t
is described by: ECO:0000269
reactant: MODEL1310110001#
reversible: true
is: SBO:0000185
name: fatty acid electroneutral transport
modifier: MODEL1310110001#
type: Reaction
fast: false
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (376497.1) or (376497.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110001#

metaR AHCYSte
is described by: ECO:0000134
product: MODEL1310110001#
fast: false
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
name: Transport of S-adenosyl-L-homocysteine
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_edaf7c92_498f_4fa4_9004_c228e72e626d
constant: false
initial concentration: NaN
is encoded by: hsa:1120
is: SBO:0000252
initial amount: NaN
name: CHKB
boundary condition: true
has only substance units: false
type: Species
is: Q9Y259

metaM f6p c
name: D-Fructose 6-phosphate
constant: false
is: HMDB00124
has only substance units: false
is: C00085
boundary condition: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/3385
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:57579

metaR SIAASE2ly
product: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
name: sialidase, lysosomal
type: Reaction

metaR FUMSO4tm
name: Fumarate:sulfate antiport, mitochondrial
is described by: ECO:0000269
fast: false
reversible: true
reactant: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
product: MODEL1310110001#
is: SBO:0000185
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_1cbf4688_7ed9_42b9_8c10_3155ea96beb0
boundary condition: true
is: Q96RQ3
is: SBO:0000252
is encoded by: hsa:56922
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
has only substance units: false
name: MCCC1

http://identifiers.org/biomodels.db/MODEL1310110001#_d4907cc5_bf34_4855_a0ec_1446e0892109
initial concentration: NaN
has part: A8K7W0
is encoded by: hsa:8876
constant: false
type: Species
name: VNN3:VNN2:VNN1
boundary condition: true
initial amount: NaN
is encoded by: hsa:55350
has only substance units: false
is encoded by: hsa:8875
has part: O95497
is: SBO:0000297

metaR TETPENT6t
reversible: true
reactant: MODEL1310110001#
is: SBO:0000185
kinetic law: MODEL1310110001#
name: fatty acid transport via diffusion
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_e66be74d_4935_4fd5_ac44_6873a71c891e
is: Q96AT9
has only substance units: false
is encoded by: hsa:6120
type: Species
initial concentration: NaN
initial amount: NaN
name: RPE
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_45df8b72_27d0_48df_9598_3ef5b1d112c5
is: SBO:0000252
boundary condition: true
is encoded by: hsa:5091
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false
name: PC

metaR D3AIBTm
type: Reaction
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
name: D-3-Amino-isobutanoate:pyruvate aminotransferase, mitochondrial
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.40 Confidence Level: 4 AUTHORS: PMID:5773299 NOTES:MM

metaM ksi pre16 g
is: HMDB00175
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 16
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:58053
type: Species
is: SBO:0000247
is: C00130
initial amount: NaN
notes: FORMULA: C157H253N11O124S4X CHARGE: -5

metaR PUNP7
name: purine-nucleoside phosphorylase (Xanthosine)
reversible: true
modifier: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.2.1
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferasextsn
type: Reaction

metaM leuktrD4 c
initial amount: NaN
name: Leukotriene D4
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C25H39N2O6S CHARGE: -1 INCHI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01664 EHMN_ABBREVIATION: C05951
is: HMDB03080
boundary condition: false
is: CHEBI:28666

metaR RE1804M
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9660774 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.14.13.15
type: Reaction
reversible: true
kinetic law: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000000
name: RE1804

http://identifiers.org/biomodels.db/MODEL1310110001#_e734eaee_3ae0_4e2d_a331_81c79b82ab82
type: Species
initial concentration: NaN
initial amount: NaN
name: VNN3:VNN2:VNN1
constant: false
is: SBO:0000297
boundary condition: true
has only substance units: false
is encoded by: hsa:55350

metaM aact c
type: Species
initial amount: NaN
is: HMDB02134
is: CHEBI:58320
name: ammonioacetone
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1S/C3H7NO/c1-3(5)2-4/h2,4H2,1H3/p+1 EHMN_ABBREVIATION: C01888
initial concentration: 1.0

metaR 34DHOXPEGt
name: 3,4-Dihydroxyphenylethyleneglycol transport (diffusion)
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:7473774 NOTES:SAB
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_5f217fa6_611f_42a8_a65d_08a93923f343
has only substance units: false
boundary condition: true
type: Species
is: Q7Z3X3
constant: false
is: SBO:0000252
name: GNS
initial amount: NaN
is encoded by: hsa:2799
initial concentration: NaN

metaM dece4coa m
initial concentration: 1.0
boundary condition: false
has only substance units: false
name: 4-decenoylcoa
type: Species
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
is: HMDB02145
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_d0c4d887_f38b_43a7_a808_c9142bbfc66e
is encoded by: hsa:3033
name: HADH
initial amount: NaN
boundary condition: true
is: Q16836
has only substance units: false
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false

metaR DNDPt33m
is described by: ECO:0000269
product: MODEL1310110001#
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000185
reversible: false
reactant: MODEL1310110001#
fast: false
type: Reaction
name: dGDP transport via dUDP antiport
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT

metaM dcdp c
is: CHEBI:58593
is: C00705
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: dCDP
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: HMDB01245
constant: false
boundary condition: false
type: Species

metaM btcoa x
initial amount: NaN
is: C00136
has only substance units: false
name: Butanoyl-CoA
notes: FORMULA: C25H38N7O17P3S CHARGE: -4
type: Species
constant: false
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: HMDB01088

metaM thbpt4acam c
is: SBO:0000247
initial amount: NaN
is: CHEBI:15374
is: HMDB02281
type: Species
initial concentration: 1.0
notes: FORMULA: C9H15N5O4 CHARGE: 0 INCHI: InChI=1S/C9H15N5O4/c1-3(15)5(16)4-2-11-6-9(18,14-4)7(17)13-8(10)12-6/h3-5,14-16,18H,2H2,1H3,(H3,10,11,12,13,17) EHMN_ABBREVIATION: CE1951
boundary condition: false
name: 4a-hydroxytetrahydrobiopterin
has only substance units: false
constant: false

metaM pydam c
initial amount: NaN
is: C00534
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: HMDB01431
is: SBO:0000247
is: CHEBI:57761
notes: FORMULA: C8H13N2O2 CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00416 EHMN_ABBREVIATION: C00534
type: Species
name: Pyridoxamine

metaR PYAM5POr
name: pyridoxamine 5'-phosphate oxidase
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.4.3.5
reversible: true
is: SBO:0000176
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:6380540 NOTES:NCD IT
is described by: ECO:0000269
fast: false
type: Reaction

metaR STRDNCCRNt
name: transport into the mitochondria (carnitine)
fast: false
kinetic law: MODEL1310110001#
is described by: ECO:0000000
modifier: MODEL1310110001#
reversible: false
is: SBO:0000185
type: Reaction
product: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

http://identifiers.org/biomodels.db/MODEL1310110001#_deef1c63_6c54_4298_80d1_f9c77a8e6d64
is encoded by: hsa:1350
is: SBO:0000252
is: P15954
has only substance units: false
boundary condition: true
name: COX7C
initial amount: NaN
constant: false
type: Species
initial concentration: NaN

metaR MAL Lte
reversible: true
reactant: MODEL1310110001#
name: Transport of L-malate
is: SBO:0000185
is described by: ECO:0000134
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
type: Reaction
kinetic law: MODEL1310110001#

metaM apoC Lys btn c
is: HMDB00182
constant: false
type: Species
notes: FORMULA: C16H27N4O3SX CHARGE: 0
boundary condition: false
has only substance units: false
initial amount: NaN
is: CHEBI:32551
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)
initial concentration: 1.0
is: SBO:0000247

metaM mercplaccys e
is: HMDB06512
has only substance units: false
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
name: 3-mercaptolactate-cysteine disulfide
type: Species
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
initial concentration: 1.0

metaR ESTSULT
product: MODEL1310110001#
reversible: false
is version of: http://identifiers.org/ec-code/2.8.2.4
modifier: MODEL1310110001#
is described by: ECO:0000269
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (6783.1) or (6817.4) or (6817.1) or (6817.3) or (6817.2) or (6817.5) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.4 Confidence Level: 4 AUTHORS: PMID:11535246,PMID:8185618 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.1
type: Reaction
is: SBO:0000176
name: Estrogen sulfotransferase
fast: false

metaR S6TASE14ly
modifier: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000000
name: N-acetylglucosamine-6-sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.14
reversible: true
type: Reaction
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_8caeb8fe_a8ab_4b57_90d2_6612c0ed4aca
has only substance units: false
is: Q9BYZ2
type: Species
name: LDHAL6B
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:92483

metaR r0021
is described by: ECO:0000000
reactant: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (954.1) or (956.1) or (377841.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:IT - fixed proton
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
is version of: http://identifiers.org/ec-code/3.6.1.5
type: Reaction
fast: false
product: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
is: SBO:0000176

metaR PUNP5
modifier: MODEL1310110001#
name: purine-nucleoside phosphorylase (Inosine)
is: SBO:0000176
product: MODEL1310110001#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_ff05869b_4e85_4bff_9a8a_5e1f0ea029af
has only substance units: false
is: Q8IX04
boundary condition: true
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
name: UEVLD
initial amount: NaN
is encoded by: hsa:55293

http://identifiers.org/biomodels.db/MODEL1310110001#_e7c742a6_2e0b_4d5d_ad30_cedba4c34d5a
has only substance units: false
initial concentration: NaN
constant: false
has part: P50993
has part: Q9UN42
name: ATP1B4:ATP1A2
boundary condition: true
is: SBO:0000297
type: Species
is encoded by: hsa:477
is encoded by: hsa:23439
initial amount: NaN

metaM 5dhf e
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C39H43N11O18 CHARGE: -6 INCHI: InChI=1/C39H47N11O18/c40-39-49-31-30(33(58)50-39)43-19(16-42-31)15-41-18-3-1-17(2-4-18)32(57)48-24(38(67)68)8-13-28(54)46-22(36(63)64)6-11-26(52)44-20(34(59)60)5-10-25(51)45-21(35(61)62)7-12-27(53)47-23(37(65)66)9-14-29(55)56/h1-4,16,20-24,41H,5-15H2,(H,44,52)(H,45,51)(H,46,54)(H,47,53)(H,48,57)(H,55,56)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H,67,68)(H3,40,42,49,50,58)/t20-,21-,22-,23-,24-/m0/s1
constant: false
name: pentaglutamyl folate (DHF)
boundary condition: false
type: Species
is: HMDB06487
initial amount: NaN

metaM tyr L m
initial amount: NaN
constant: false
name: L-tyrosine
is: CHEBI:17895
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB00158
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085

http://identifiers.org/biomodels.db/MODEL1310110001#_ed6011f9_d9f9_46e5_b26c_9732873ec6f4
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:7390
name: UROS
is: P10746
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_90e4fa40_f27f_4c58_b499_72c2c6a10b70
is: O75752
initial amount: NaN
is encoded by: hsa:8706
constant: false
boundary condition: true
type: Species
is: SBO:0000252
name: B3GALNT1
has only substance units: false
initial concentration: NaN

metaM 2hexdtricoa m
boundary condition: false
name: 2,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
type: Species
is: HMDB02288
has only substance units: false
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN

metaM 5mthf e
is: CHEBI:3729
notes: FORMULA: C20H24N7O6 CHARGE: -1
boundary condition: false
is: SBO:0000247
name: 5-Methyltetrahydrofolate
is: HMDB01396
initial amount: NaN
constant: false
type: Species
has only substance units: false
is: C00440
initial concentration: 1.0

metaR KAS8
modifier: MODEL1310110001#
reversible: false
reactant: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
name: b-ketoacyl synthetase (palmitate, n-C16:0)
type: Reaction
fast: false
product: MODEL1310110001#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.85 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.85

metaM thym c
initial amount: NaN
constant: false
boundary condition: false
initial concentration: 1.0
is: CHEBI:17821
name: Thymine
type: Species
has only substance units: false
is: HMDB00262
is: SBO:0000247
notes: FORMULA: C5H6N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
is: C00178

http://identifiers.org/biomodels.db/MODEL1310110001#_509a0574_970c_4e2d_bf06_6aa3a25a9ed8
type: Species
boundary condition: true
is: P10619
name: CTSA
initial concentration: NaN
constant: false
is encoded by: hsa:5476
has only substance units: false
initial amount: NaN
is: SBO:0000252

metaR TALA
is version of: http://identifiers.org/ec-code/2.2.1.2
is described by: ECO:0000000
reactant: MODEL1310110001#
modifier: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
reversible: true
kinetic law: MODEL1310110001#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (6888.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.2.1.2 Confidence Level: 0 AUTHORS: NOTES:SMP
name: transaldolase

metaR EX 4abut LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Aminobutanoate exchange
type: Reaction

metaM pcrn m
is: http://identifiers.org/pubchem.compound/107738
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
name: propionyl-carnitine
is: HMDB00824
has only substance units: false
constant: false

metaR r0022
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (AA532636.1) or (2936.1) SUBSYSTEM: Glutathione metabolism EC Number: 1.8.1.7 Confidence Level: 0 AUTHORS: PMID:10781871,PMID:12821209,PMID:237878,PMID:31912,PMID:4380255,PMID:8981046,PMID:9621574 NOTES:
is described by: ECO:0000000
product: MODEL1310110001#
type: Reaction
name: glutathione:NAD+ oxidoreductase Glutamate metabolism EC:1.8.1.7
fast: false
reversible: true
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.8.1.7
is: SBO:0000176

metaM ttdcrn c
constant: false
is: http://identifiers.org/pubchem.compound/3413344
name: tetradecanoyl carnitine
type: Species
has only substance units: false
notes: FORMULA: C21H41NO4 CHARGE: 0 INCHI: InChI=1/C21H41NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-21(25)26-19(17-20(23)24)18-22(2,3)4/h19H,5-18H2,1-4H3/t19-/m1/s1
boundary condition: false
is: SBO:0000247
is: HMDB05066
initial amount: NaN
initial concentration: 1.0

metaR PUNP6
is: SBO:0000176
name: purine-nucleoside phosphorylase (Deoxyinosine)
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:14706628,PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is version of: http://identifiers.org/ec-code/2.4.2.1
type: Reaction
product: MODEL1310110001#
reversible: true
modifier: MODEL1310110001#
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_4397ba6c_1940_413c_8e27_a68409dc768b
initial concentration: NaN
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:2643
name: GCH1
is: Q8IZH9

metaR r0707
modifier: MODEL1310110001#
product: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.168
reactant: MODEL1310110001#
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate phosphohydrolase (alkaline optimum) Folate biosynthesis EC:3.1.3.1
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (1629.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777 NOTES:
is: SBO:0000176
reversible: true

metaR ADA
kinetic law: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.5.4.4
is: SBO:0000176
reactant: MODEL1310110001#
name: Adenosine deaminase
notes: GENE_ASSOCIATION: (100.1) SUBSYSTEM: Purine catabolism EC Number: 3.5.4.4 Confidence Level: 4 AUTHORS: PMID:12381379,PMID:15016824 NOTES:Added EC- JLR
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000269
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110001#_f19e5592_5f3f_4d1c_af5e_6a47a799b415
is encoded by: hsa:10195
initial amount: NaN
constant: false
initial concentration: NaN
is: SBO:0000252
name: ALG3
type: Species
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_01738498_7ca9_4a90_b209_f80e4128c064
name: COQ6
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is: B7Z3K8
boundary condition: true
is encoded by: hsa:51004
initial amount: NaN

metaR CYTK1n
fast: false
reversible: true
reactant: MODEL1310110001#
modifier: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
name: cytidylate kinase (CMP),nuclear
is: SBO:0000176

metaR DOLICHOL Uter
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110001#
type: Reaction
reversible: true
name: dolichol diffusion, human (uterus)
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:

metaR ADPCOAPTE
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of adipoyl coA for release into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_2bfe7809_9ade_4db0_9d7a_b6c161f60e02
is: Q53HE2
name: TPI1
constant: false
is encoded by: hsa:7167
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN

metaM pydx c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
has only substance units: false
type: Species
is: CHEBI:17310
is: C00250
boundary condition: false
name: Pyridoxal
notes: FORMULA: C8H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00227 EHMN_ABBREVIATION: C00250
constant: false
is: HMDB01545

metaM man1p c
is: SBO:0000247
name: D-Mannose 1-phosphate
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: InChI=1S/C6H13O9P/c7-1-2-3(8)4(9)5(10)6(14-2)15-16(11,12)13/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00466 EHMN_ABBREVIATION: C00636
type: Species
boundary condition: false
constant: false
initial concentration: 1.0
is: CHEBI:35374
has only substance units: false
is: HMDB06330
initial amount: NaN

metaR SPHK21c
reversible: false
kinetic law: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.91
name: sphingosine kinase 2
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (56848.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10751414 NOTES:NJ
product: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
modifier: MODEL1310110001#

metaR r2137
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
fast: false
reversible: true
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
modifier: MODEL1310110001#

metaR RE2814R
reactant: MODEL1310110001#
name: RE2814
is described by: ECO:0000000
reversible: true
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
type: Reaction
fast: false

metaM val L m
type: Species
constant: false
has only substance units: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
initial amount: NaN
initial concentration: 1.0
name: L-valine
boundary condition: false
is: CHEBI:16414
is: HMDB00883
is: SBO:0000247

metaM mercplaccys c
is: HMDB06512
constant: false
is: SBO:0000247
notes: FORMULA: C6H10O5S2N CHARGE: -1 INCHI: InChI=1/C6H11NO5S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4,8H,1-2,7H2,(H,9,10)(H,11,12)/t3-,4?/m0/s1
type: Species
has only substance units: false
initial concentration: 1.0
initial amount: NaN
name: 3-mercaptolactate-cysteine disulfide
boundary condition: false

metaR G14T13g
is version of: http://identifiers.org/ec-code/2.4.1.22
kinetic law: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.90
reversible: false
product: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
is: SBO:0000176
is described by: ECO:0000000
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.38

metaM mev R c
initial concentration: 1.0
name: (R)-mevalonate
is: HMDB00227
is: SBO:0000247
constant: false
is: CHEBI:36464
boundary condition: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_a4b28710_023a_45d6_84ae_578abb2a73c1
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:29880
is: Q9Y673
initial amount: NaN
name: ALG5
initial concentration: NaN
type: Species
boundary condition: true

metaR PDE1
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.4.17
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (5139.1) or (5142.1) or (5151.3) or (5153.1) or (5150.2) or (5143.1) or (5150.1) or (5137.1) or (5144.1) or (5136.2) or (5140.2) or (5151.2) or (10846.1) or (5151.5) or (5140.1) or (5141.1) or (5138.1) or (5136.1) or (5151.4) or (5151.1) or (27115.1) or (50940.1) or (8622.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.4.17 Confidence Level: 4 AUTHORS: PMID:10725373,PMID:10872825,PMID:10906126,PMID:10952971,PMID:11050148,PMID:11114167,PMID:12038792,PMID:12135876,PMID:12154085,PMID:12388353,PMID:12681444,PMID:12764607,PMID:14604994,PMID:15147193,PMID:15272012,PMID:15480303,PMID:8884271,PMID:9210593,PMID:9419816 NOTES:NCD
reversible: false
name: 3',5'-cyclic-nucleotide phosphodiesterase
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.4.35
reactant: MODEL1310110001#
type: Reaction
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_8bce6a85_0251_4c29_abfe_dc2cccea206d
type: Species
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:7001
constant: false
name: PRDX2
has only substance units: false
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_668d175c_8890_4165_95c7_1b7ff350a272
is: GO:0005615
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: extracellular space
type: Compartment

metaR PUNP3
type: Reaction
fast: false
reversible: true
is described by: ECO:0000269
name: purine-nucleoside phosphorylase (Guanosine)
modifier: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_26c5aef2_9789_4322_891a_ce629d01bd8c
is: SBO:0000252
type: Species
name: ADCY5
is encoded by: hsa:111
initial amount: NaN
is: O95622
constant: false
boundary condition: true
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_d1e18915_bb05_48cf_aa0a_cf0f0c6926ee
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
initial concentration: NaN
is encoded by: hsa:517
has only substance units: false
type: Species
is: SBO:0000297
constant: false
initial amount: NaN
boundary condition: true
has part: Q06055

metaR TETTET6COAtx
fast: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
reactant: MODEL1310110001#
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185

metaM tchola x
is: SBO:0000247
is: HMDB00036
initial amount: NaN
notes: FORMULA: C26H45NO7S CHARGE: 0 INCHI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/p-1/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
type: Species
constant: false
boundary condition: false
name: taurocholate
is: CHEBI:36257
has only substance units: false
initial concentration: 1.0

metaR r0706
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (34.1) or (3712.1) or (R14373.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356170,PMID:8943006 NOTES:RE1814X
product: MODEL1310110001#
name: acyl-Coenzyme A dehydrogenase family, member 9 Bile acid biosynthesis EC:1.3.3.6
kinetic law: MODEL1310110001#
reversible: false
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.99.10
reactant: MODEL1310110001#

metaR CYTK1m
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 1 AUTHORS: PMID:17999954 NOTES:No evidence in the mitochondrion
fast: false
is described by: ECO:0000134
reactant: MODEL1310110001#
reversible: true
product: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000176
name: cytidylate kinase (CMP),mitochondrial

metaM g3m8mpdol L r
is: SBO:0000247
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
boundary condition: false
notes: FORMULA: C1960H3228N20O770P20 CHARGE: -20
is: HMDB01342
is: C00459
has only substance units: false
is: CHEBI:37568
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false

metaR FACOAL140i
is: SBO:0000176
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase (tetradecanoate)
notes: GENE_ASSOCIATION: (2181.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:JLR
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: false
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000269

metaM 5mthf c
is: HMDB01396
constant: false
type: Species
notes: FORMULA: C20H24N7O6 CHARGE: -1
boundary condition: false
name: 5-Methyltetrahydrofolate
initial amount: NaN
is: CHEBI:3729
is: C00440
initial concentration: 1.0
is: SBO:0000247
has only substance units: false

metaM thym e
boundary condition: false
is: CHEBI:17821
initial concentration: 1.0
name: thymine
type: Species
has only substance units: false
is: HMDB00262
is: SBO:0000247
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_36f36287_3a82_41d8_a9f3_3f35c03905a7
constant: false
has only substance units: false
boundary condition: true
is: P22303
initial concentration: NaN
is encoded by: hsa:43
is: SBO:0000252
type: Species
name: ACHE
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_e8f456cb_4e01_4658_b807_7b446afb3e53
is: SBO:0000252
name: ADSL
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:158

metaR r2136
modifier: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
reversible: false
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.14.6
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12811560 NOTES:
fast: false
is: SBO:0000185
kinetic law: MODEL1310110001#

metaM ahcys c
notes: FORMULA: C14H20N6O5S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00031 EHMN_ABBREVIATION: C00021
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00939
constant: false
boundary condition: false
is: CHEBI:16680
has only substance units: false
initial concentration: 1.0
is: C00021
name: S-Adenosyl-L-homocysteine

metaM dpcoa l
name: 3'-dephospho-CoA(2-)
is: HMDB01373
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
constant: false
initial concentration: 1.0
is: CHEBI:57328
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_592e1952_fd71_4bf1_9bac_87308332dbd3
is encoded by: hsa:5152
type: Species
has only substance units: false
constant: false
boundary condition: true
name: PDE9A
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_76ab30fc_d6c6_430f_b5be_2727ac9f761d
is: Q6LEN6
name: CHAT
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:1103
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_c60592fb_bb2f_460b_bf0d_64fc5d96b8b8
is: B2R6S5
boundary condition: true
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:51727
name: CMPK1
constant: false

metaR THBPT4ACAMDASE
reversible: false
is: SBO:0000176
name: Tetrahydrobiopterin-4a-carbinolamine dehydratase
kinetic law: MODEL1310110001#
is described by: ECO:0000269
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.2.1.96
fast: false
type: Reaction
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (5092.1) or (5092.2) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 4 AUTHORS: PMID:10727395 NOTES:SAB based on PMID 10727395

http://identifiers.org/biomodels.db/MODEL1310110001#_6df64431_3217_4895_8a69_ecd39e6ad65a
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:55089
has only substance units: false
name: SLC38A4
is: SBO:0000252
type: Species
is: Q969I6
initial concentration: NaN

metaR PUNP4
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
product: MODEL1310110001#
reversible: true
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.2.1
name: purine-nucleoside phosphorylase (Deoxyguanosine)
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110001#

metaR H2O2t
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:AMF
fast: false
product: MODEL1310110001#
reactant: MODEL1310110001#
name: hydrogen peroxide transport via diffusion
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
reversible: true

metaM dec47dicoa x
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
name: 4,7-decadienoylcoa
constant: false
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR FAOXC1811602m
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.8.1
reactant: MODEL1310110001#
name: Beta oxidation fatty acid
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
is described by: ECO:0000000
reversible: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_5 rounds of beta ox, 1 loss of degree of unsat -> 4 fad oxidized c18:1 -> c8:0 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
type: Reaction
product: MODEL1310110001#

metaR PUNP1
fast: false
reactant: MODEL1310110001#
reversible: true
name: purine-nucleoside phosphorylase (Adenosine)
modifier: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
is described by: ECO:0000269
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.2.1
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
type: Reaction

metaR EX q10h2 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinol
type: Reaction

metaR LSTO1r
name: Lathosterol oxidase
modifier: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.14.21.6
is: SBO:0000176
reversible: false
product: MODEL1310110001#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (6309.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.3.2 Confidence Level: 4 AUTHORS: PMID:10344195 NOTES:lanosterol -> cholesterol pathway NJ

http://identifiers.org/biomodels.db/MODEL1310110001#_99e53e6d_2460_40ce_8c1b_d73c3b7c92ea
has only substance units: false
initial amount: NaN
name: GALNT10
type: Species
is: Q86SR1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:55568

metaM din e
is: C05512
is: CHEBI:28997
is: HMDB00071
type: Species
name: Deoxyinosine
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
has only substance units: false
boundary condition: false
initial concentration: 1.0
constant: false

metaM dpcoa m
is: SBO:0000247
constant: false
is: CHEBI:57328
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB01373
has only substance units: false
name: 3'-dephospho-CoA(2-)
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 INCHI: InChI=1S/C21H35N7O13P2S/c1-21(2,16(32)19(33)24-4-3-12(29)23-5-6-44)8-39-43(36,37)41-42(34,35)38-7-11-14(30)15(31)20(40-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-32,44H,3-8H2,1-2H3,(H,23,29)(H,24,33)(H,34,35)(H,36,37)(H2,22,25,26)/p-2/t11-,14-,15-,16+,20-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
boundary condition: false

metaM dhcholoylcoa x
initial concentration: 1.0
is: CHEBI:27393
constant: false
initial amount: NaN
boundary condition: false
notes: FORMULA: C48H74N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h9,24-26,28-34,36,38-40,44,56-57,59-60H,7-8,10-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
is: HMDB06895
is: SBO:0000247
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA
has only substance units: false
type: Species

metaM gchola c
has only substance units: false
type: Species
is: CHEBI:58235
is: SBO:0000247
notes: FORMULA: C26H43NO6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00863 EHMN_ABBREVIATION: C01921
boundary condition: false
is: HMDB00138
name: glycocholate
initial amount: NaN
constant: false
initial concentration: 1.0

metaM 4h2oglt m
is: SBO:0000247
notes: FORMULA: C5H4O6 CHARGE: -2 INCHI: InChI=1S/C5H6O6/c6-2(4(8)9)1-3(7)5(10)11/h2,6H,1H2,(H,8,9)(H,10,11)/p-2
is: HMDB02070
has only substance units: false
name: 4-hydroxy-2-oxoglutarate(2-)
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: CHEBI:17742
type: Species

metaM val L c
has only substance units: false
type: Species
is: SBO:0000247
constant: false
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
name: L-valine
initial concentration: 1.0
is: CHEBI:16414
boundary condition: false
initial amount: NaN
is: HMDB00883

metaR DUDPtn
name: dUDP nuclear transport
fast: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true

metaR PUNP2
reversible: true
modifier: MODEL1310110001#
is: SBO:0000176
name: purine-nucleoside phosphorylase (Deoxyadenosine)
is version of: http://identifiers.org/ec-code/2.4.2.1
fast: false
reactant: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (4860.1) SUBSYSTEM: Purine catabolism EC Number: 3.4.2.1 Confidence Level: 4 AUTHORS: PMID:6087295,PMID:9305963 NOTES:Specificity not completely determined. Can also catalyse ribosyltransferase reactions of the type catalysed by EC 2.4.2.5, nucleoside ribosyltransferase
is described by: ECO:0000269
product: MODEL1310110001#
kinetic law: MODEL1310110001#

metaM acnam n
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB00230
name: N-acetylneuraminate
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
is: CHEBI:35418
constant: false
is: SBO:0000247
type: Species

metaR SUBERICACT
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of suberic acid for formation of suberyl carnitine
type: Reaction

metaR EX C04849 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate exchange
type: Reaction

metaM dhlpro m
notes: FORMULA: H2S2X CHARGE: 0 EHMN_ABBREVIATION: C02972
is: CHEBI:16194
initial concentration: 1.0
constant: false
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
has only substance units: false
name: Dihydrolipolprotein

metaR EX HC02203 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin-a2 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_8546a649_c2dc_4f0b_b342_5809e8773eaf
constant: false
name: CLYBL
type: Species
initial amount: NaN
is encoded by: hsa:171425
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM hdd2crn m
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB06317
name: trans-Hexadec-2-enoyl carnitine
type: Species
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
constant: false
initial amount: NaN

metaR EX ala D LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: D-Alanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_fae7ed65_79e1_4dcc_ab55_688af9e7b2d4
is: SBO:0000252
has only substance units: false
type: Species
is: Q6LEN5
constant: false
name: CHAT
initial concentration: NaN
initial amount: NaN
boundary condition: true
is encoded by: hsa:1103

metaR EX dlnlcg LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: dihomo-gamma-linolenic acid (n-6) exchange
type: Reaction

metaM udpglcur c
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C15H19N2O18P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00162 EHMN_ABBREVIATION: C00167
has only substance units: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: HMDB00935
name: UDP-D-glucuronate
is: CHEBI:58052
is: C00167

metaM hmbil c
name: Hydroxymethylbilane
is: CHEBI:57845
type: Species
initial amount: NaN
is: HMDB01137
has only substance units: false
is: C01024
constant: false
is: SBO:0000247
notes: FORMULA: C40H38N4O17 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00628 EHMN_ABBREVIATION: C01024
initial concentration: 1.0
boundary condition: false

metaM ahcys e
constant: false
notes: FORMULA: C14H20N6O5S CHARGE: 0
name: S-Adenosyl-L-homocysteine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:16680
is: C00021
initial amount: NaN
boundary condition: false
type: Species
is: HMDB00939

metaM L2aadp c
is: CHEBI:58672
type: Species
boundary condition: false
constant: false
initial amount: NaN
initial concentration: 1.0
name: L-2-aminoadipate(1-)
is: HMDB00510
has only substance units: false
notes: FORMULA: C6H10NO4 CHARGE: -1 INCHI: InChI=1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/p-1/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00599 EHMN_ABBREVIATION: C00956
is: SBO:0000247

metaR ASAH1
type: Reaction
is described by: ECO:0000000
fast: false
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.5.1.23
reversible: false
reactant: MODEL1310110001#
name: N-acylsphingosine amidohydrolase
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (427.1) or (427.2) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.5.1.23 Confidence Level: 4 AUTHORS: PMID:8955159 NOTES:NJ
product: MODEL1310110001#
is: SBO:0000176

metaR DLNLCGt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110001#
fast: false
is described by: ECO:0000000
is: SBO:0000185
name: fatty acid transport via diffusion
reactant: MODEL1310110001#
reversible: true
type: Reaction
kinetic law: MODEL1310110001#

metaR RE0689E
product: MODEL1310110001#
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000000
reversible: false
type: Reaction
name: RE0689
reactant: MODEL1310110001#

metaR NADPHtxu
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:10521434 NOTES:diffusion - unidirectional to avoid NADP/NAD loops w/ free hydrogens NJ
name: NADPH transporter, peroxisome
is: SBO:0000185
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reversible: false
type: Reaction
reactant: MODEL1310110001#
fast: false
is described by: ECO:0000000

metaR GACPAILter
is described by: ECO:0000000
product: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
type: Reaction
reversible: false
kinetic law: MODEL1310110001#
name: glucosaminyl-acylphosphatidylinositol ER flippase
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:14517336 NOTES:NCD
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110001#_e7d9b0d7_3ac1_48cc_a379_4038bec25a51
initial amount: NaN
is: B4DGD7
boundary condition: true
constant: false
name: IDS
is: SBO:0000252
is encoded by: hsa:3423
type: Species
has only substance units: false
initial concentration: NaN

metaR RE1522M
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
reactant: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110001#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
fast: false
name: RE1522

metaM din c
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00071
name: Deoxyinosine
constant: false
initial amount: NaN
is: C05512
is: CHEBI:28997
notes: FORMULA: C10H12N4O4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01493 EHMN_ABBREVIATION: C05512
initial concentration: 1.0
type: Species

metaR EX gam LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for D-Glucosamine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_b0807860_bda5_44ad_9108_53185a585a51
initial amount: NaN
name: AOC2
is encoded by: hsa:314
is: O75106
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_db98a34a_99a3_48a4_abf1_27c432d3ac67
is: Q9BQL0
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:594
boundary condition: true
name: BCKDHB
initial amount: NaN
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_76804888_c6e8_4502_b00e_116c02fa9701
name: _AI926493_1_m
boundary condition: true
constant: false
has only substance units: false
is encoded by: hsa:AI926493
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN

metaR r0027
product: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (285973.1) or (D29675.1) or (4842.1) or (NOS2A.1) or (4846.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.8.1.9 Confidence Level: 0 AUTHORS: PMID:18042542 NOTES:
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.14.13.39
name: NADPH:CoA-glutathione oxidoreductase EC:1.8.1.9
reversible: true
is described by: ECO:0000000
type: Reaction

metaM hpdcacrn m
type: Species
initial concentration: 1.0
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
initial amount: NaN
boundary condition: false
is: SBO:0000247
name: heptadecanoyl carnitine
constant: false
is: HMDB06210
has only substance units: false

metaM lnlncgcoa m
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:57363
is: HMDB06368
name: gamma-linolenoyl-CoA(4-)
has only substance units: false
is: SBO:0000247

metaM ksii core2 pre9 g
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C75H120N6O59S2X CHARGE: -3
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 9
constant: false
is: CHEBI:28067

http://identifiers.org/biomodels.db/MODEL1310110001#_13427268_f8fa_403d_a588_dc429fb6f9fb
initial concentration: NaN
boundary condition: true
constant: false
type: Species
name: OXSM
has only substance units: false
is: Q9NWU1
is encoded by: hsa:54995
initial amount: NaN
is: SBO:0000252

metaM gdpmann c
initial concentration: 1.0
is: CHEBI:57527
constant: false
name: GDP-alpha-D-mannose(2-)
is: HMDB01163
notes: FORMULA: C16H23N5O16P2 CHARGE: -2 INCHI: InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23)4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/p-2/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00098 EHMN_ABBREVIATION: C00096
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
initial amount: NaN

metaR MAN6PI
modifier: MODEL1310110001#
name: mannose-6-phosphate isomerase
fast: false
kinetic law: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (4351.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.3.1.8 Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/5.3.1.8
is described by: ECO:0000304
is: SBO:0000176
product: MODEL1310110001#
reversible: true

metaM 3php c
is: CHEBI:18110
notes: FORMULA: C3H2O7P CHARGE: -3 INCHI: InChI=1S/C3H5O7P/c4-2(3(5)6)1-10-11(7,8)9/h1H2,(H,5,6)(H2,7,8,9)/p-3 HEPATONET_1.0_ABBREVIATION: HC01082 EHMN_ABBREVIATION: C03232
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
name: 3-phosphonatooxypyruvate(3-)
is: HMDB01024
boundary condition: false

metaR EX tdchola LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: taurochenodeoxycholate exchange
type: Reaction

metaM 3octdectecoa x
has only substance units: false
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
constant: false
name: 3,6,9,12-octadecatetraenoylcoa
is: SBO:0000247
type: Species
boundary condition: false
notes: FORMULA: C39H58N7O17P3S CHARGE: -4

metaR EX so4 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sulfate exchange
type: Reaction

metaR H2MTer L
reversible: false
reactant: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (55650.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15623507 NOTES:NCD
modifier: MODEL1310110001#
product: MODEL1310110001#
name: H2 mannosyltransferase, endoplasmic reticulum
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110001#
fast: false

metaR METtec
product: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
reversible: true
name: L-methionine transport via diffusion (extracellular to cytosol)
type: Reaction
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
modifier: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_60777c2d_0e56_42ad_8318_8caf4720ac47
boundary condition: true
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
name: SLC25A18
initial amount: NaN
is encoded by: hsa:83733
is: Q9H1K4

metaR r1401
is version of: http://identifiers.org/ec-code/2.3.1.51
modifier: MODEL1310110001#
name: Facilitated diffusion
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000185
fast: false
is version of: http://identifiers.org/ec-code/2.7.10.1
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.35
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (AA177072.1) or (AA203143.1) or (56894.1) or (56895.1) or (AGPAT7.1) or (AI818585.1) or (AI971023.1) or (1956.1) or (54898.1) or (60481.1) or (79071.1) or (114799.1) or (157570.1) or (8372.1) or (LOC647190.1) or (9926.1) or (129642.1) or (MBOAT5.1) or (79143.1) or (N63787.1) or (54995.1) or (80339.1) or (9197.1) or (6901.1) or (W87865.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:6361812,PMID:8132483 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.41
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.1.3

http://identifiers.org/biomodels.db/MODEL1310110001#_f04566df_ba5e_4509_9589_4bfc1c574fd0
is: SBO:0000252
type: Species
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q8N5Z0
is encoded by: hsa:51166
constant: false
name: AADAT
has only substance units: false

metaR RE2814M
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:0 NOTES:
is described by: ECO:0000000
fast: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000176
name: RE2814
type: Reaction
reactant: MODEL1310110001#

metaR PHCHGSm
is: SBO:0000176
type: Reaction
product: MODEL1310110001#
reversible: true
is described by: ECO:0000000
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:taken from KEGG map. No enzyme assigned, so assumed this is a non-enzymatic reaction. NCD
name: L-1-Pyrroline-3-hydroxy-5-carboxylate spontaneous conversion to L-4-Hydroxyglutamate semialdehyde, mitochondrial

metaR 7DHCHSTEROLtr
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:specific mechanism not known, proton dependence for trans-mit transport has been suggested, however directionality and stoichiometry has not yet been elucidated. see PMID: 12770731 and others NJ
name: cholesterol precursor intracellular transport
is: SBO:0000185
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110001#

metaR PPA
notes: GENE_ASSOCIATION: (5464.1) SUBSYSTEM: Oxidative phosphorylation EC Number: 3.6.1.1 Confidence Level: 4 AUTHORS: PMID:10542310,PMID:15533045 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.1
is described by: ECO:0000269
modifier: MODEL1310110001#
type: Reaction
fast: false
product: MODEL1310110001#
reversible: false
reactant: MODEL1310110001#
is: SBO:0000176
name: inorganic diphosphatase
kinetic law: MODEL1310110001#

metaM 56dthm m
initial amount: NaN
is: SBO:0000247
is: HMDB00079
name: 5,6-dihydrothymine
type: Species
is: CHEBI:27468
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false
notes: FORMULA: C5H8N2O2 CHARGE: 0 INCHI: InChI=1S/C5H8N2O2/c1-3-2-6-5(9)7-4(3)8/h3H,2H2,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00582 EHMN_ABBREVIATION: C00906

metaM btcoa m
type: Species
has only substance units: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
is: CHEBI:57371
initial concentration: 1.0
name: Butanoyl-CoA
is: SBO:0000247
is: C00136
initial amount: NaN
is: HMDB01088
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_85af4c26_4812_4a0b_bf47_20357f43642a
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
type: Species
is encoded by: hsa:4967
boundary condition: true
is: B4E3E9
name: OGDH
initial amount: NaN

metaM 3hodcoa c
type: Species
initial amount: NaN
is: HMDB13336
name: (S)-3-Hydroxyoctadecanoyl-CoA
has only substance units: false
notes: FORMULA: C39H66N7O18P3S CHARGE: -4
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_411da6f1_1b7c_4a9b_b9ee_82b83a6039de
boundary condition: true
type: Species
initial amount: NaN
is encoded by: hsa:126129
has only substance units: false
is: Q8TCG5
is: SBO:0000252
name: CPT1C
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_e506c4e9_0baf_43b2_86df_2cf6afdaf56c
constant: false
is encoded by: hsa:54872
initial amount: NaN
boundary condition: true
name: PIGF:PIGG
has only substance units: false
has part: Q8NCI4
is: SBO:0000297
initial concentration: NaN
type: Species

metaM c8dc x
is: HMDB00893
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C15H26NO6 CHARGE: -1
initial concentration: 1.0
has only substance units: false
constant: false
name: suberyl carnitine

metaM pcrn c
constant: false
boundary condition: false
notes: FORMULA: C10H19NO4 CHARGE: 0 INCHI: InChI=1/C10H19NO4/c1-5-10(14)15-8(6-9(12)13)7-11(2,3)4/h8H,5-7H2,1-4H3
is: http://identifiers.org/pubchem.compound/107738
name: propionyl-carnitine
type: Species
is: HMDB00824
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_fdca705d_d224_4c64_b670_3c5a47f8d6e9
is: SBO:0000252
has only substance units: false
name: NDUFS8
is encoded by: hsa:4728
initial concentration: NaN
is: O00217
initial amount: NaN
constant: false
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_cd8387d4_e55d_4786_9dd1_c9883eaec5e4
is: SBO:0000252
has only substance units: false
is encoded by: hsa:2110
type: Species
initial concentration: NaN
boundary condition: true
is: Q16134
constant: false
name: ETFDH
initial amount: NaN

metaM dmnoncrn x
is: HMDB06202
initial amount: NaN
name: 4,8-dimethylnonanoyl carnitine
boundary condition: false
has only substance units: false
notes: FORMULA: C18H37NO4 CHARGE: 0
type: Species
initial concentration: 1.0
is: SBO:0000247
constant: false

metaM aicar e
initial amount: NaN
is: SBO:0000247
is: CHEBI:58475
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: C04677
type: Species
notes: FORMULA: C9H13N4O8P CHARGE: -2
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: HMDB01517
constant: false

metaM lnlncacoa c
initial concentration: 1.0
is: CHEBI:51985
type: Species
is: HMDB06290
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
name: alpha-Linolenoyl-CoA
has only substance units: false
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809

http://identifiers.org/biomodels.db/MODEL1310110001#_5b06234f_2c95_4c40_a6aa_337415d3e3d7
constant: false
has only substance units: false
is: Q9UEF7
initial concentration: NaN
type: Species
initial amount: NaN
name: KL
is: SBO:0000252
boundary condition: true
is encoded by: hsa:9365

http://identifiers.org/biomodels.db/MODEL1310110001#_4a3bcad6_ae3e_4c71_bad1_aaf0e90a6f7d
is: P26439
constant: false
is encoded by: hsa:3284
name: HSD3B2
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

metaR EX decdicrn
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decadienoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_a32f03b9_4e3a_41ed_93b4_8e3627bfe72d
boundary condition: true
is: Q9UHI7
is encoded by: hsa:9963
initial amount: NaN
type: Species
initial concentration: NaN
name: SLC23A1
has only substance units: false
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_4617c16c_9fd9_4fff_923e_6853f59f8e9c
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: _AI824319_1_r
constant: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:AI824319

metaR 2MB2COAc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 2-methylcrotonoyl-CoA into cytosol
type: Reaction

metaM tyr L e
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
is: HMDB00158
type: Species
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
initial concentration: 1.0
is: CHEBI:17895
name: L-tyrosine

http://identifiers.org/biomodels.db/MODEL1310110001#_16467435_3451_43a6_956b_96bb2fc615f0
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:26279
constant: false
type: Species
name: PLA2G2D
boundary condition: true
has only substance units: false
is: SBO:0000252
is: Q9UNK4

metaM adrncoa x
notes: FORMULA: C43H66N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H70N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4-7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-/t32-,36-,37-,38?,42-/m1/s1
has only substance units: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/47205480
constant: false
is: C16170
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: adrenyl coenzyme A

metaR RE1709C
type: Reaction
reactant: MODEL1310110001#
is described by: ECO:0000000
reversible: true
is: SBO:0000176
product: MODEL1310110001#
name: RE1709
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:8921004 NOTES:
fast: false

metaM core2 g
name: Core 2
constant: false
type: Species
is: CHEBI:15876
initial amount: NaN
notes: FORMULA: C22H37N2O15X CHARGE: 0
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: SBO:0000247

metaM acmanap c
is: CHEBI:58557
constant: false
type: Species
initial amount: NaN
is: HMDB01121
is: SBO:0000247
has only substance units: false
name: N-acetyl-D-mannosamine 6-phosphate(2-)
initial concentration: 1.0
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-4(11)9-5(2-10)7(13)8(14)6(12)3-18-19(15,16)17/h2,5-8,12-14H,3H2,1H3,(H,9,11)(H2,15,16,17)/p-2 HEPATONET_1.0_ABBREVIATION: HC01257 EHMN_ABBREVIATION: C04257
boundary condition: false

metaR r2404
kinetic law: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000
modifier: MODEL1310110001#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
product: MODEL1310110001#
fast: false
reversible: false

metaR C12DCACT
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of Dodecanedioic acid
type: Reaction

metaR BDHm
type: Reaction
kinetic law: MODEL1310110001#
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
reversible: true
reactant: MODEL1310110001#
fast: false
is: SBO:0000176
modifier: MODEL1310110001#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.30
notes: GENE_ASSOCIATION: (622.2) or (622.3) or (622.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.1.1.30 Confidence Level: 4 AUTHORS: PMID:1639787,PMID:8679568 NOTES:IT
product: MODEL1310110001#

metaR r0309
is described by: ECO:0000000
product: MODEL1310110001#
kinetic law: MODEL1310110001#
name: trans-Hexadec-2-enoyl-CoA reductase Fatty acid elongation in mitochondria EC:1.3.1.38
modifier: MODEL1310110001#
reversible: true
is version of: http://identifiers.org/ec-code/1.4.3.22
fast: false
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.1.38 Confidence Level: 0 AUTHORS: PMID:12654921 NOTES:
reactant: MODEL1310110001#
is: SBO:0000176
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_6ca962e4_4509_4895_b8ef_83683dacc8ae
initial amount: NaN
type: Species
initial concentration: NaN
is: Q6FGA0
constant: false
is encoded by: hsa:9167
boundary condition: true
is: SBO:0000252
name: COX7A2L
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_a92b244b_5a0a_470f_b317_34c9cc72249e
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:1340
type: Species
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P14854
name: COX6B1

metaR FAOXC5OHc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: (3-hydroxyisovalerylcoa-->3-hydroxyisovalerylcarnitine)c
type: Reaction

metaM val L e
type: Species
is: HMDB00883
initial amount: NaN
has only substance units: false
is: CHEBI:16414
boundary condition: false
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C5H11NO2 CHARGE: 0 INCHI: InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00174
name: L-valine

metaR FAOXC8C6m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C8-->C6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_518ff1aa_ca71_4f28_9356_8f2a802aed87
has part: Q6FIH7
is: SBO:0000297
initial amount: NaN
constant: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G1:ATP5I:ATP5J:ATP5J2
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:516

metaR GLYCLTtp
type: Reaction
name: glycolate transport into peroxisome
is described by: ECO:0000000
kinetic law: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#
reversible: false
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:15240345 NOTES:NCD

metaM aicar c
constant: false
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide
is: CHEBI:58475
initial amount: NaN
notes: FORMULA: C9H13N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01334 EHMN_ABBREVIATION: C04677
is: SBO:0000247
is: C04677
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
is: HMDB01517

metaM ahdt e
type: Species
constant: false
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: 7,8-dihydroneopterin 3'-triphosphate(4-)
initial amount: NaN
is: SBO:0000247
is: CHEBI:58462
is: HMDB00980
notes: FORMULA: C9H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C9H16N5O13P3/c10-9-13-7-5(8(17)14-9)12-3(1-11-7)6(16)4(15)2-25-29(21,22)27-30(23,24)26-28(18,19)20/h4,6,15-16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H4,10,11,13,14,17)/p-4/t4-,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01367 EHMN_ABBREVIATION: C04895

metaM acnam l
is: CHEBI:35418
initial amount: NaN
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
notes: FORMULA: C11H18NO9 CHARGE: -1 INCHI: InChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/p-1/t5-,6+,7+,8+,9+,11?/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00244 EHMN_ABBREVIATION: C00270
type: Species
name: N-acetylneuraminate
is: HMDB00230
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_2471b04e_4495_4bd3_87c6_197599c949bb
is: P11908
initial amount: NaN
boundary condition: true
has only substance units: false
constant: false
is encoded by: hsa:5634
initial concentration: NaN
is: SBO:0000252
name: PRPS2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_a8220e6b_f297_4e8a_ba8f_5e9f678a1383
name: ECI1
is encoded by: hsa:1632
initial amount: NaN
has only substance units: false
is: P42126
type: Species
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

metaR SPRMTDe
is: SBO:0000185
type: Reaction
reversible: true
name: absorption for spermine across the basolateral side
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Larqu? E, Sabater-Molina M, Zamora S. (2007). Nutrition 23: 87-95, PMID: 11564949. NOTES:polyamines are taken up by diffusion process, although specific carriers and para-cellular transport has also been documented.

metaR PCHOLP hs
name: choline phosphatase
notes: GENE_ASSOCIATION: (5338.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:9395408,PMID:9582313 NOTES:NJ
fast: false
product: MODEL1310110001#
reactant: MODEL1310110001#
reversible: false
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.4.4
type: Reaction
modifier: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000269

metaM thym m
is: CHEBI:17821
notes: FORMULA: C5H6N2O2 CHARGE: 0 INCHI: InChI=1S/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9) HEPATONET_1.0_ABBREVIATION: HC00170 EHMN_ABBREVIATION: C00178
type: Species
has only substance units: false
initial amount: NaN
boundary condition: false
name: thymine
constant: false
is: HMDB00262
initial concentration: 1.0
is: SBO:0000247

metaM cs e l
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), free chain
initial concentration: 1.0
initial amount: NaN
is: HMDB02183
notes: FORMULA: C45H64N2O55S6 CHARGE: -8
constant: false
boundary condition: false
is: SBO:0000247
is: CHEBI:36005
type: Species

metaR FAOXC142C142OHm
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C14:2OH)m
type: Reaction

metaR THP2Ctp
product: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:MM
is described by: ECO:0000000
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate transport, peroxisomal
kinetic law: MODEL1310110001#
reversible: true
is: SBO:0000185

metaR r0308
reactant: MODEL1310110001#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 3.1.2.22 Confidence Level: 0 AUTHORS: PMID:10092594,PMID:6151837 NOTES:
fast: false
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
type: Reaction
product: MODEL1310110001#
name: Palmitoyl-CoA hydrolase Fatty acid elongation in mitochondria EC:3.1.2.22 EC:3.1.2.2

metaM tyr L c
is: CHEBI:17895
constant: false
name: L-tyrosine
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00158
notes: FORMULA: C9H11NO3 CHARGE: 0 INCHI: InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00085
boundary condition: false
initial concentration: 1.0
is: SBO:0000247

metaR DECDICRNe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of decadienoyl carnitine into the extra cellular space
type: Reaction

metaR r1621
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000185

metaM pap c
has only substance units: false
type: Species
name: adenosine 3',5'-bismonophosphate(4-)
constant: false
is: CHEBI:58343
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: HMDB00061
boundary condition: false

metaM dolglcp L c
is: CHEBI:15812
is: SBO:0000247
type: Species
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
constant: false
initial concentration: 1.0
boundary condition: false
has only substance units: false

metaM xoltriol m
is: CHEBI:16496
initial concentration: 1.0
is: SBO:0000247
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
boundary condition: false
type: Species
is: HMDB01457
initial amount: NaN
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_9153557b_14a2_4fbc_a590_4924007eb13c
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: O43272
type: Species
boundary condition: true
name: PRODH
constant: false
is encoded by: hsa:5625
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_86eb7da1_0aec_4956_9c0c_99907619fd0d
is encoded by: hsa:4166
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
name: CHST6
is: Q9GZX3

metaR HCO3 CLt
is described by: ECO:0000269
reactant: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
name: bicarbonate transport (Cl-/HCO3- exchange)
type: Reaction
notes: GENE_ASSOCIATION: (6522.1) or (83697.1) or (6521.1) or (6508.2) or (6508.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11302728,PMID:12027221,PMID:14722772 NOTES:MM
is: SBO:0000185
product: MODEL1310110001#
modifier: MODEL1310110001#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_5f68e2ec_fc2e_4411_bcc3_d1954c59e3e3
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: P42765
has only substance units: false
is: SBO:0000252
name: ACAA2
initial amount: NaN
is encoded by: hsa:10449

metaM pchol hs m
initial concentration: 1.0
type: Species
initial amount: NaN
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02000 EHMN_ABBREVIATION: C00157
is: SBO:0000247
constant: false
name: Phosphatidylcholine
is: CHEBI:16110
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_cd6bb273_aabc_42ad_aff4_8d2499ebafe3
boundary condition: true
has only substance units: false
is encoded by: hsa:29922
name: NME7
is: Q9Y5B8
is: SBO:0000252
type: Species
initial amount: NaN
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_841a6651_364a_4be2_a1f2_4f7aaf3900b3
has only substance units: false
is encoded by: hsa:H45672
constant: false
initial concentration: NaN
boundary condition: true
type: Species
initial amount: NaN
is: SBO:0000252
name: _H45672_1_m

metaR 2HBO
type: Reaction
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.27
fast: false
name: 2-Hydroxybutyrate:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (92483.1) or (3948.2) or (55293.1) or (3945.1 and 3939.1) or (3939.1) or (160287.1) or (3945.1) or (3948.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.27 Confidence Level: 4 AUTHORS: PMID:10108,PMID:21765 NOTES:NCD

metaM tetdec2crn c
is: HMDB02014
initial concentration: 1.0
has only substance units: false
type: Species
name: tetradecadienoyl carnitine
notes: FORMULA: C21H37NO4 CHARGE: 0
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_a80b4e9b_0f54_4009_be66_25f658a222f8
name: PLA2G4A
constant: false
boundary condition: true
is encoded by: hsa:5321
type: Species
is: P47712
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_7d31da0e_5bd3_4d3d_b0d8_87843ed1dc55
is: P04746
boundary condition: true
name: AMY2A
type: Species
is encoded by: hsa:279
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
has only substance units: false

metaR UGLT
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) SUBSYSTEM: Galactose metabolism EC Number: 2.7.7.12 Confidence Level: 0 AUTHORS: PMID:12923184 NOTES:NCD
is described by: ECO:0000000
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.7.12
modifier: MODEL1310110001#
product: MODEL1310110001#
name: UDPglucose--hexose-1-phosphate uridylyltransferase
is: SBO:0000176

metaR r1622
modifier: MODEL1310110001#
fast: false
reversible: true
kinetic law: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110001#_ebfad607_6eb2_4188_b498_7830920d7541
is encoded by: hsa:5294
name: PIK3CG
type: Species
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
is: P48736
initial amount: NaN
has only substance units: false

metaR SIAT9g
is version of: http://identifiers.org/ec-code/2.4.99.9
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (8869.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.9 Confidence Level: 4 AUTHORS: PMID:9822625 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110001#
type: Reaction
fast: false
modifier: MODEL1310110001#
name: Lactosylceramide alpha-2,3-sialyltransferase, Golgi apparatus
is: SBO:0000176
product: MODEL1310110001#
reversible: false

metaM ksii core2 e
constant: false
has only substance units: false
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
is: HMDB00211
is: CHEBI:17268
name: keratan sulfate II (core 2-linked)
boundary condition: false

metaR PIt7
type: Reaction
kinetic law: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (10050.1) or (10786.1) or (10246.1) or (6568.1) or (6569.1) or (10568.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889,PMID:12811560,PMID:8815811 NOTES:Merged GPRs from PIt7 and PIt7r. May 2011 IT
reactant: MODEL1310110001#
is described by: ECO:0000269
is: SBO:0000185
name: phosphate transport in/out via three Na+ symporter
modifier: MODEL1310110001#
reversible: true
product: MODEL1310110001#

metaR sink tetdec2coa LPAREN c RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDEC2COASINK
type: Reaction

metaM hpdcacrn c
is: SBO:0000247
type: Species
is: HMDB06210
has only substance units: false
boundary condition: false
constant: false
notes: FORMULA: C24H47NO4 CHARGE: 0 INCHI: InChI=1/C24H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-24(28)29-22(20-23(26)27)21-25(2,3)4/h22H,5-21H2,1-4H3
initial concentration: 1.0
name: heptadecanoyl carnitine
initial amount: NaN

metaR RE3568C
fast: false
product: MODEL1310110001#
reversible: true
name: RE3568
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:234423 NOTES:
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#

metaR r0870
is version of: http://identifiers.org/ec-code/3.6.1.1
name: Facilitated diffusion
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (AA419122.1) or (AA576959.1) or (64077.1) or (8776.1) or (8898.1) or (9107.1) or (29085.1) or (8611.1) or (8613.1) or (8612.1) or (81537.1) or (130367.1) or (23517.1) or (51095.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409,PMID:17466261 NOTES:
is version of: http://identifiers.org/ec-code/2.7.7.72
is: SBO:0000185
is version of: http://identifiers.org/ec-code/3.6.4.13
is version of: http://identifiers.org/ec-code/3.1.3.4
modifier: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#

metaR SERPT
product: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110001#
reversible: false
name: serine C-palmitoyltransferase
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.3.1.50 Confidence Level: 4 AUTHORS: NOTES:NCD
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.50
type: Reaction
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_4f8e0302_fc86_499f_bcdf_13ba70b4178a
has only substance units: false
initial amount: NaN
initial concentration: NaN
name: ATP5J2
constant: false
is encoded by: hsa:9551
is: SBO:0000252
boundary condition: true
type: Species
is: F8W7V3

metaR EX glygn4 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

metaM lnlncgcoa c
initial amount: NaN
is: HMDB06368
constant: false
boundary condition: false
name: gamma-linolenoyl-CoA(4-)
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h8-9,11-12,14-15,26-28,32-34,38,49-50H,4-7,10,13,16-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/p-4/b9-8-,12-11-,15-14-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: C03035
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
type: Species
is: CHEBI:57363

metaR r0130
notes: GENE_ASSOCIATION: (LOC374569.1) SUBSYSTEM: Glutathione metabolism EC Number: 3.4.11.4 Confidence Level: 0 AUTHORS: PMID:1968061,PMID:3511062 NOTES:
is: SBO:0000176
reactant: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
is described by: ECO:0000000
product: MODEL1310110001#
type: Reaction
reversible: true
name: gamma-glutamyltranspeptidase Glutathione metabolism EC:3.4.11.4
kinetic law: MODEL1310110001#

metaR RE3004M
reactant: MODEL1310110001#
name: RE3004
fast: false
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_a8a8325d_892e_472c_9f7b_3c58f16ae93a
is: SBO:0000252
has only substance units: false
initial concentration: NaN
name: SLC2A13
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:114134
is: Q96QE2
type: Species

metaM mev R x
initial amount: NaN
name: (R)-mevalonate
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H11O4 CHARGE: -1 INCHI: InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/p-1/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00343
is: HMDB00227
is: CHEBI:36464
constant: false
is: SBO:0000247
has only substance units: false

metaR PPM
modifier: MODEL1310110001#
name: phosphopentomutase
reversible: true
kinetic law: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/5.4.2.2
notes: GENE_ASSOCIATION: (5236.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: NOTES:
fast: false

metaR FAOXC184C163x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:4-->C16:3)x
type: Reaction

metaR r0246
reversible: false
is described by: ECO:0000000
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.5.1.3
fast: false
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
kinetic law: MODEL1310110001#
is: SBO:0000176
reactant: MODEL1310110001#
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.72 EC:1.1.1.2
type: Reaction
modifier: MODEL1310110001#

metaR G14T6g
reversible: false
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.38
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.22
fast: false
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is: SBO:0000176

metaR LEUtec
name: L-leucine transport via diffusion (extracellular to cytosol)
is: SBO:0000185
fast: false
modifier: MODEL1310110001#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
reversible: true
type: Reaction
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#

metaR PIt8
notes: GENE_ASSOCIATION: (6574.1) or (6575.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12759754 NOTES:MM
reversible: true
kinetic law: MODEL1310110001#
fast: false
name: phosphate transport in/out via Na+ symporter
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000006
is: SBO:0000185
type: Reaction
product: MODEL1310110001#

metaM gcald c
is: CHEBI:17071
notes: FORMULA: C2H4O2 CHARGE: 0 INCHI: InChI=1S/C2H4O2/c3-1-2-4/h1,4H,2H2 EHMN_ABBREVIATION: C00266
initial amount: NaN
is: HMDB03344
type: Species
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
name: glycolaldehyde
initial concentration: 1.0

metaR r0871
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14977409 NOTES:
name: Diffusion
reactant: MODEL1310110001#
fast: false
type: Reaction
product: MODEL1310110001#
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110001#
is: SBO:0000185

metaM adpcoa x
is: HMDB04047
type: Species
boundary condition: false
initial amount: NaN
name: adipoylcoa
is: SBO:0000247
constant: false
is: C14143
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C27H39N7O19P3S CHARGE: -5

metaM tetdec2crn e
initial concentration: 1.0
type: Species
constant: false
has only substance units: false
name: tetradecadienoyl carnitine
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C21H37NO4 CHARGE: 0
is: HMDB05066
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_c582f955_72bc_44e4_aa06_21b2d23ae600
has only substance units: false
initial concentration: NaN
name: MTMR3
initial amount: NaN
type: Species
constant: false
boundary condition: true
is encoded by: hsa:8897
is: SBO:0000252

metaR DRBK
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 2.7.1.15 Confidence Level: 2 AUTHORS: PMID:9693094 NOTES:NCD
name: Deoxyribokinase
product: MODEL1310110001#
is: SBO:0000176
reversible: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.1.15
is described by: ECO:0000304
kinetic law: MODEL1310110001#
type: Reaction
fast: false
modifier: MODEL1310110001#

metaM ksii core4 deg4 l
boundary condition: false
notes: FORMULA: C66H108N6O48SX CHARGE: -1
initial amount: NaN
type: Species
name: keratan sulfate II (core 4-linked), degradation product 4
constant: false
initial concentration: 1.0
is: CHEBI:57455
has only substance units: false
is: HMDB01354
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_b155ff49_2d77_4a41_a7c7_d035d924b122
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
name: _286297_1_c
type: Species
is encoded by: hsa:286297

metaM ctp c
is: C00063
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
name: CTP
boundary condition: false
is: CHEBI:37563
is: HMDB00082
has only substance units: false
notes: FORMULA: C9H12N3O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00066 EHMN_ABBREVIATION: C00063

metaM txa2 c
type: Species
is: SBO:0000247
is: CHEBI:57445
has only substance units: false
constant: false
is: HMDB01452
name: thromboxane A2(1-)
initial amount: NaN
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
initial concentration: 1.0
boundary condition: false

metaM mhista c
notes: FORMULA: C6H12N3 CHARGE: 1 INCHI: InChI=1S/C6H11N3/c1-9-4-6(2-3-7)8-5-9/h4-5H,2-3,7H2,1H3/p+1 EHMN_ABBREVIATION: C05127
boundary condition: false
type: Species
name: N(tele)-methylhistaminium
initial amount: NaN
initial concentration: 1.0
is: HMDB00898
is: CHEBI:58600
is: SBO:0000247
constant: false
has only substance units: false

metaM HC00250 c
boundary condition: false
notes: FORMULA: HS CHARGE: -1 INCHI: InChI=1S/H2S/h1H2/p-1 EHMN_ABBREVIATION: C00283
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
name: hydrosulfide
has only substance units: false
is: SBO:0000247
is: CHEBI:29919

metaR PIt9
type: Reaction
name: phosphate transport in/out via two Na+ symporter
notes: GENE_ASSOCIATION: (142680.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12750889 NOTES:MM
fast: false
reactant: MODEL1310110001#
is described by: ECO:0000006
kinetic law: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#
reversible: true
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_34b54265_7090_49ec_aa69_fc816db7c6f2
is: SBO:0000252
name: AMPD2
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: E9PNG0
has only substance units: false
is encoded by: hsa:271
type: Species

metaM CE0849 m
is: CHEBI:57795
notes: FORMULA: C37H58N7O17P3S CHARGE: -4 INCHI: InChI=1/C37H62N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h8-9,11-12,24-26,30-32,36,47-48H,4-7,10,13-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE0849
type: Species
constant: false
name: cis,cis-palmito-7,10-dienoyl-CoA
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR BUP2
notes: GENE_ASSOCIATION: (51733.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.1.6 Confidence Level: 4 AUTHORS: PMID:11508704,PMID:5773299 NOTES:MM
type: Reaction
product: MODEL1310110001#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.1.6
name: beta-ureidopropionase (D-3-amino-isobutanoate forming)

http://identifiers.org/biomodels.db/MODEL1310110001#_4d426305_f413_4cf9_9c10_f1dc9d5ffbfe
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
name: CHST2
initial concentration: NaN
is: Q9Y4C5
boundary condition: true
is encoded by: hsa:9435
type: Species

metaR r2408
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110001#
is: SBO:0000185
type: Reaction
fast: false
product: MODEL1310110001#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.19.1
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (8402.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
modifier: MODEL1310110001#

metaR r0245
reactant: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.72 Confidence Level: 0 AUTHORS: PMID:11716357,PMID:6753936,PMID:6815419,PMID:8916913,PMID:9693960 NOTES:
is: SBO:0000176
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.5.1.3
name: Glycerol:NADP+ oxidoreductase Glycerolipid metabolism EC:1.1.1.2 EC:1.1.1.72

metaR r1620
kinetic law: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
fast: false
is described by: ECO:0000000
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true

metaM HC01361 e
notes: FORMULA: C9H13N5O4 CHARGE: 0 INCHI: InChI=1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1 EHMN_ABBREVIATION: C04874
name: Dihydroneopterin
is: CHEBI:17001
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN

metaR r0450
is version of: http://identifiers.org/ec-code/4.2.1.3
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Lysine metabolism EC Number: 2.6.1.39 Confidence Level: 0 AUTHORS: PMID:8087205 NOTES:
is: SBO:0000176
type: Reaction
name: L-2-Aminoadipate:2-oxoglutarate aminotransferase Lysine biosynthesis / Lysine degradation EC:2.6.1.39
fast: false
modifier: MODEL1310110001#
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_41ad89b7_521a_4fcc_aaf9_4c2e358dddfe
is: SBO:0000252
is: Q9NRA2
name: SLC17A5
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:26503

metaM cortsn r
is: CHEBI:16962
is: HMDB02802
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
boundary condition: false
name: cortisone
notes: FORMULA: C21H28O5 CHARGE: 0 INCHI: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1 EHMN_ABBREVIATION: C00762
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_9d369ac5_6067_4957_b290_c4eda0004eb4
has only substance units: false
boundary condition: true
type: Species
is: P30049
is encoded by: hsa:513
initial concentration: NaN
name: ATP5D
constant: false
is: SBO:0000252
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_c6b079a7_16a8_4c60_bf4c_d0ee735ebfbc
type: Species
is: Q96DU7
is encoded by: hsa:80271
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
boundary condition: true
is: SBO:0000252
name: ITPKC

metaR r1625
type: Reaction
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110001#
fast: false
reversible: true
product: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000

metaM CE5236 n
constant: false
type: Species
initial amount: NaN
boundary condition: false
is: CHEBI:28002
name: O2'-4a-cyclic-tetrahydrobiopterin
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: HMDB03952
has only substance units: false

metaM pap g
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C10H11N5O10P2 CHARGE: -4 INCHI: InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7(25-27(20,21)22)4(24-10)1-23-26(17,18)19/h2-4,6-7,10,16H,1H2,(H2,11,12,13)(H2,17,18,19)(H2,20,21,22)/p-4/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00059 EHMN_ABBREVIATION: C00054
is: HMDB00061
initial amount: NaN
name: adenosine 3',5'-bismonophosphate(4-)
type: Species
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:58343

metaR LEUt5m
fast: false
kinetic law: MODEL1310110001#
type: Reaction
name: leucine mitochondrial transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
is: SBO:0000185
reversible: true
reactant: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#

metaR DHDPBMTm
reactant: MODEL1310110001#
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: 2.1.1.114 Confidence Level: 4 AUTHORS: PMID:10777520,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.1.1.114 IT
reversible: false
name: dihydroxydecaprenylbenzoate methyltransferase
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.1.1.114
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#

metaM mpdol L c
boundary condition: false
notes: FORMULA: C1300H2128N20O220P20 CHARGE: -20 INCHI: InChI=1S/C47H82N2O22P2/c1-26(2)13-9-14-27(3)15-10-16-28(4)17-11-18-29(5)19-12-20-30(6)21-22-64-72(60,61)71-73(62,63)70-46-37(49-32(8)54)40(57)43(35(25-52)67-46)68-45-36(48-31(7)53)39(56)44(34(24-51)66-45)69-47-42(59)41(58)38(55)33(23-50)65-47/h13,15,17,19,30,33-47,50-52,55-59H,9-12,14,16,18,20-25H2,1-8H3,(H,48,53)(H,49,54)(H,60,61)(H,62,63)/b27-15+,28-17+,29-19+/t30?,33-,34-,35-,36-,37-,38-,39-,40-,41+,42+,43-,44-,45+,46-,47+/m1/s1
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:18396
constant: false
initial concentration: 1.0
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog
is: SBO:0000247

metaM gbside hs g
is: CHEBI:18259
name: globoside
boundary condition: false
notes: FORMULA: C44H79N2O22FULLRCO CHARGE: 0
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
has only substance units: false
initial concentration: 1.0

metaR EX lnlc LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange
type: Reaction

metaM lneldccoa c
initial concentration: 1.0
name: linoelaidyl coenzyme A
has only substance units: false
notes: FORMULA: C39H62N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
is: HMDB06521
is: http://identifiers.org/pubchem.compound/9543677
type: Species
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_81c2130a_ec39_4be8_89cb_5a2a3bc8e97d
initial amount: NaN
boundary condition: true
is encoded by: hsa:1375
name: CPT1B
constant: false
is: E9PCP2
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaM sbt D e
boundary condition: false
initial concentration: 1.0
name: D-glucitol
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: HMDB00247
has only substance units: false

metaM txa2 e
type: Species
initial concentration: 1.0
is: CHEBI:57445
is: HMDB01452
is: SBO:0000247
initial amount: NaN
constant: false
name: thromboxane A2(1-)
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/p-1/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1 EHMN_ABBREVIATION: C02198
boundary condition: false
has only substance units: false

metaR FACOAL80i
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase (octanoate)
product: MODEL1310110001#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (2181.1) or (2181.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.2 Confidence Level: 4 AUTHORS: NOTES:JLR Also 6.2.1.3
fast: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110001#
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: false

metaR DOLP Lter
type: Reaction
fast: false
kinetic law: MODEL1310110001#
name: dolichol phosphate flippase (liver)
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:

metaR r0456
reversible: false
name: ATP:deoxyguanosine 5-phosphotransferase Purine metabolism EC:2.7.1.113
product: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
is version of: http://identifiers.org/ec-code/2.7.1.32
is described by: ECO:0000000
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (AA614647.1) or (1120.1) or (1374.1) or (1375.1) or (126129.1) or (1376.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.113 Confidence Level: 0 AUTHORS: PMID:15748706 NOTES:
type: Reaction
is: SBO:0000176
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_eb57c260_33b1_4f75_8377_3a8c5822eeb5
is: SBO:0000252
boundary condition: true
initial amount: NaN
name: ALDH1A1
initial concentration: NaN
has only substance units: false
type: Species
is: P00352
constant: false
is encoded by: hsa:216

http://identifiers.org/biomodels.db/MODEL1310110001#_866f0d3b_1eb7_4db4_9e66_5b120003712e
is: SBO:0000252
has only substance units: false
name: _AA419122_1_c
boundary condition: true
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:AA419122
constant: false

metaR r1626
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110001#
fast: false
product: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
is: SBO:0000185

metaR H6ET3er
product: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
name: H6 phosphoethanolaminyl transferase, endoplasmic reticulum
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (84720.2) and (5281.1) or (84720.1) and (5281.2) or (5281.1) and (84720.1) or (84720.2) and (5281.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10781593,PMID:8463218 NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
reversible: false
is version of: http://identifiers.org/ec-code/2.7.8.1

metaM aact m
name: ammonioacetone
boundary condition: false
is: SBO:0000247
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
is: HMDB02134
is: CHEBI:58320
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1S/C3H7NO/c1-3(5)2-4/h2,4H2,1H3/p+1 EHMN_ABBREVIATION: C01888
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_9e971b3a_3f19_4871_a1b3_38f37a3eae40
boundary condition: true
name: ATP5J2
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q6IBB3
initial amount: NaN
has only substance units: false
is encoded by: hsa:9551

metaR EX o2 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for oxugen
type: Reaction

metaR SACCD4m
type: Reaction
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.10 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
kinetic law: MODEL1310110001#
name: saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial
product: MODEL1310110001#
reversible: false
is version of: http://identifiers.org/ec-code/1.5.1.8
fast: false
is: SBO:0000176
is described by: ECO:0000269
reactant: MODEL1310110001#

metaM m2gacpail hs r
notes: FORMULA: C43H78NO24PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: SBO:0000247
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:16038
has only substance units: false
boundary condition: false
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)

metaM cala c
boundary condition: false
has only substance units: false
name: N-carbamoyl-beta-alaninate
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB00026
is: CHEBI:11892
notes: FORMULA: C4H7N2O3 CHARGE: -1 INCHI: InChI=1S/C4H8N2O3/c5-4(9)6-2-1-3(7)8/h1-2H2,(H,7,8)(H3,5,6,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00975 EHMN_ABBREVIATION: C02642
initial concentration: 1.0
constant: false

metaM aacoa x
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:57286
constant: false
is: SBO:0000247
type: Species
is: HMDB01484
notes: FORMULA: C25H36N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-12,14,18-20,24,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t14-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00282 EHMN_ABBREVIATION: C00332
boundary condition: false
name: acetoacetyl-CoA(4-)

metaR r1623
type: Reaction
reactant: MODEL1310110001#
modifier: MODEL1310110001#
reversible: true
product: MODEL1310110001#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_7487f1a2_8ca0_4e12_84a5_3c6701ed7a81
boundary condition: true
constant: false
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: PDE9A
is encoded by: hsa:5152
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_b516fa49_b551_4948_a37d_c5e4a5504e90
type: Species
boundary condition: true
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P54819
is encoded by: hsa:204
name: AK2
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_f441eea7_88bb_4e31_bfe9_cce55dfa3d19
name: ST3GAL3
boundary condition: true
constant: false
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:6487
initial amount: NaN
initial concentration: NaN

metaM lnlncacoa m
constant: false
initial concentration: 1.0
initial amount: NaN
name: alpha-Linolenoyl-CoA
is: HMDB06290
notes: FORMULA: C39H60N7O17P3S CHARGE: -4 INCHI: InChI=1S/C39H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h5-6,8-9,11-12,26-28,32-34,38,49-50H,4,7,10,13-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b6-5-,9-8-,12-11-/t28-,32-,33-,34+,38-/m1/s1 EHMN_ABBREVIATION: CE4809
boundary condition: false
is: SBO:0000247
is: CHEBI:51985
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_6e981df4_874b_4d7e_a332_fb0e3c44f72f
constant: false
initial amount: NaN
is encoded by: hsa:2878
is: SBO:0000252
has only substance units: false
name: GPX3
boundary condition: true
initial concentration: NaN
type: Species
is: P22352

metaM btcoa c
is: SBO:0000247
is: C00136
is: CHEBI:57371
is: HMDB01088
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00134 EHMN_ABBREVIATION: C00136
boundary condition: false
has only substance units: false
name: Butanoyl-CoA
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_0df6e1a9_951d_41f4_b8bf_25bac94849aa
is: SBO:0000252
name: TAZ
initial amount: NaN
is: Q16635
boundary condition: true
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6901
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_390318d7_13d6_4bfd_8e81_f4d90421e5ec
is: Q5JPA4
name: SLCO1C1
has only substance units: false
type: Species
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:53919
initial amount: NaN
initial concentration: NaN

metaR DLNLCGCRNt
type: Reaction
reversible: false
product: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
modifier: MODEL1310110001#
fast: false

metaM sbt D c
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
is: CHEBI:17924
constant: false
is: HMDB00247
name: D-glucitol
notes: FORMULA: C6H14O6 CHARGE: 0 INCHI: InChI=1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4+,5-,6-/m1/s1
boundary condition: false
initial amount: NaN

metaM HC01407 m
boundary condition: false
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C27H42N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H46N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-16,20-22,26,35,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t15-,16+,20+,21+,22-,26+/m0/s1 EHMN_ABBREVIATION: C05268
name: (S)-Hydroxyhexanoyl-CoA
is: SBO:0000247
is: CHEBI:28276
initial amount: NaN
has only substance units: false

metaR AG13T12g
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
kinetic law: MODEL1310110001#
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110001#_44a03e9a_16bb_4119_a50d_12f65edce3e2
is encoded by: hsa:1375
is: Q53FV7
constant: false
name: CPT1B
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaR 2HCO3 NAt
notes: GENE_ASSOCIATION: (57835.3) or (8671.1) or (57835.2) or (57835.1) or (57835.4) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14722772 NOTES:MM
is described by: ECO:0000269
is: SBO:0000185
name: bicarbonate transport (Na/HCO3 1:2 cotransport)
kinetic law: MODEL1310110001#
type: Reaction
reversible: true
reactant: MODEL1310110001#
modifier: MODEL1310110001#
product: MODEL1310110001#
fast: false

metaR RE2998M
is version of: http://identifiers.org/ec-code/1.3.3.6
kinetic law: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
reversible: false
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
name: RE2998
type: Reaction

metaR ADSS
type: Reaction
reversible: false
product: MODEL1310110001#
name: adenylosuccinate synthase
is: SBO:0000176
kinetic law: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) SUBSYSTEM: Nucleotide interconversion EC Number: 6.3.4.4 Confidence Level: 2 AUTHORS: PMID:1592113 NOTES:r0277
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.3.4.4
is described by: ECO:0000134

metaR MCCCrm
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: true
is version of: http://identifiers.org/ec-code/6.4.1.4
modifier: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
name: methylcrotonoyl-CoA carboxylase, mitochondrial
notes: GENE_ASSOCIATION: (56922.1 and 64087.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.4 Confidence Level: 4 AUTHORS: PMID:11181649,PMID:11406611 NOTES:MM
is: SBO:0000176
is described by: ECO:0000269
fast: false

metaR r0249
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2592.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.3.1.6 Confidence Level: 0 AUTHORS: PMID:14690456,PMID:14988808,PMID:15234337,PMID:2843500 NOTES:
is: SBO:0000176
fast: false
kinetic law: MODEL1310110001#
reversible: true
type: Reaction
modifier: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.7.12
name: D-Ribose-5-phosphate ketol-isomerase Pentose phosphate pathway EC:5.3.1.6
reactant: MODEL1310110001#

metaR SEBCOAPET
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of sebacoylcoa for release into cytosol
type: Reaction

metaR r1624
modifier: MODEL1310110001#
fast: false
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (19.1) or (AL038231.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction

metaM ksii core2 g
is: HMDB01644
initial amount: NaN
constant: false
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
type: Species
name: keratan sulfate II (core 2-linked)
boundary condition: false
initial concentration: 1.0
is: CHEBI:17140
has only substance units: false
is: SBO:0000247

metaR SIAT4Bg
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.99.4
reactant: MODEL1310110001#
is described by: ECO:0000269
name: Beta-galactoside alpha-2,3-sialyltransferase, Golgi apparatus
type: Reaction
notes: GENE_ASSOCIATION: (6483.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.4 Confidence Level: 4 AUTHORS: PMID:9266697 NOTES:NJ
reversible: false
product: MODEL1310110001#
modifier: MODEL1310110001#

metaR TETHEX3COAtx
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
product: MODEL1310110001#
name: fatty acid intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is: SBO:0000185
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_73539fd3_90d7_4eef_9c98_4f81fef2d6c5
is: SBO:0000252
name: GALNT7
constant: false
has only substance units: false
is: Q86SF2
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:51809
initial concentration: NaN

metaM tdcoa m
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
initial concentration: 1.0
is: CHEBI:57385
initial amount: NaN
type: Species
is: HMDB01521
is: SBO:0000247
name: Tetradecanoyl-CoA (n-C14:0CoA)
boundary condition: false
is: C02593
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_3e17781f_8dac_4fae_b93c_e7d330a37d0d
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: B3GNT8
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:374907

metaM m8mpdol L r
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
constant: false
notes: FORMULA: C1780H2928N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1 EHMN_ABBREVIATION: C05868
is: SBO:0000247
type: Species
is: CHEBI:59093

metaM hgentis c
is: HMDB00130
initial concentration: 1.0
initial amount: NaN
boundary condition: false
notes: FORMULA: C8H7O4 CHARGE: -1 INCHI: InChI=1S/C8H8O4/c9-6-1-2-7(10)5(3-6)4-8(11)12/h1-3,9-10H,4H2,(H,11,12)/p-1 HEPATONET_1.0_ABBREVIATION: HC00423 EHMN_ABBREVIATION: C00544
type: Species
has only substance units: false
name: homogentisate
is: CHEBI:16169
constant: false
is: SBO:0000247

metaM lgnc c
constant: false
is: CHEBI:31014
initial amount: NaN
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
is: HMDB02003
is: SBO:0000247
name: lignocerate
initial concentration: 1.0
has only substance units: false
boundary condition: false
type: Species

metaM naglc2p U c
is: CHEBI:18278
boundary condition: false
notes: FORMULA: C1105H1810N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
is: SBO:0000247
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog
type: Species
has only substance units: false
initial concentration: 1.0
constant: false
initial amount: NaN

metaM c8dc c
is: HMDB00791
boundary condition: false
constant: false
is: C02838
is: SBO:0000247
type: Species
name: suberyl carnitine
notes: FORMULA: C15H26NO6 CHARGE: -1
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR MDHm
modifier: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.37
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (4191.1) SUBSYSTEM: Citric acid cycle EC Number: 1.1.1.37 Confidence Level: 0 AUTHORS: PMID:15565635,PMID:9933076 NOTES:IF. Biochemical
reversible: true
type: Reaction
fast: false
name: malate dehydrogenase, mitochondrial
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110001#_bfebecbc_5414_4d09_b85f_80162b4cf632
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
is encoded by: hsa:728441
type: Species
initial amount: NaN
initial concentration: NaN
name: GGT2

metaR PROt4 2 r
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
is: SBO:0000185
is described by: ECO:0000006
name: Proline transport (sodium symport) (2:1)
notes: GENE_ASSOCIATION: (6534.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
product: MODEL1310110001#
reversible: true
modifier: MODEL1310110001#

metaR r2142
reactant: MODEL1310110001#
modifier: MODEL1310110001#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
fast: false
type: Reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
is: SBO:0000185

metaR C162OHe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: excretion of C16:2OH
type: Reaction

metaM cmpacna c
has only substance units: false
is: CHEBI:57812
boundary condition: false
is: SBO:0000247
initial amount: NaN
name: CMP-N-acetyl-beta-neuraminate(2-)
is: HMDB01176
type: Species
initial concentration: 1.0
constant: false
notes: FORMULA: C20H29N4O16P CHARGE: -2 INCHI: InChI=1S/C20H31N4O16P/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34)/p-2/t8-,9+,10+,12+,13+,14+,15+,16+,17+,20+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00126 EHMN_ABBREVIATION: C00128

metaR r0139
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
reversible: true
product: MODEL1310110001#
fast: false
is: SBO:0000176
name: CDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.2.2

metaR sink c81coa LPAREN c RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: C81COASINK
type: Reaction

metaM dolmanp L c
is: CHEBI:15809
boundary condition: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
name: Dolichyl phosphate D-mannose, human liver homolog

metaR r1629
product: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
type: Reaction

metaR PHEACGLNt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14681857 NOTES:SAB
type: Reaction
fast: false
is: SBO:0000185
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
name: PHEACGLN extracellular transport via diffusion
reactant: MODEL1310110001#
reversible: true

metaM CE5236 c
type: Species
has only substance units: false
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1/C9H13N5O3/c1-3-5(15)4-2-11-6-9(14-4,17-3)7(16)13-8(10)12-6/h3-5,14-15H,2H2,1H3,(H3,10,11,12,13,16)/p+1/t3-,4u,5+,9u/m0/s1 EHMN_ABBREVIATION: CE5236
is: CHEBI:28002
is: HMDB03952
name: O2'-4a-cyclic-tetrahydrobiopterin
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_09860737_0d03_4dbc_ae76_30dbca10fb9b
initial concentration: NaN
is: SBO:0000252
is: B2RDZ2
constant: false
has only substance units: false
type: Species
initial amount: NaN
boundary condition: true
is encoded by: hsa:55312
name: RFK

http://identifiers.org/biomodels.db/MODEL1310110001#_e16f5a15_555b_440d_96d8_fe4fcf3bb31c
type: Species
constant: false
has only substance units: false
name: SLC24A2
initial concentration: NaN
is: Q9UI40
is encoded by: hsa:25769
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaR ILEtec
is: SBO:0000185
type: Reaction
product: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12930836,PMID:14624363,PMID:15659399 NOTES:SAB
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
name: L-isoleucine transport via diffusion (extracellular to cytosol)
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_6b41da2f_b2d9_4b55_b58c_4b881a342cd6
is encoded by: hsa:AI090874
has only substance units: false
initial concentration: NaN
initial amount: NaN
name: _AI090874_1_c
boundary condition: true
is: SBO:0000252
constant: false
type: Species

metaR GLYCLTDy
kinetic law: MODEL1310110001#
reversible: false
is: SBO:0000176
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (9380.1) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: 1.1.1.79 Confidence Level: 4 AUTHORS: PMID:1252411,PMID:15240345,PMID:2689175 NOTES:JLR
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.79
reactant: MODEL1310110001#
product: MODEL1310110001#
name: Glycolate dehydrogenase (NADP)
fast: false

metaR FAOXC164C143m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C14:3)m
type: Reaction

metaM mgacpail hs r
type: Species
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)
is: C00249
initial concentration: 1.0
constant: false
boundary condition: false
is: CHEBI:7896
is: SBO:0000247
notes: FORMULA: C37H68NO19PFULLRCO2FULLR2CO2 CHARGE: 0
initial amount: NaN
is: HMDB00220
has only substance units: false

metaR S4TASE4ly
is version of: http://identifiers.org/ec-code/3.1.6.12
name: N-acetylgalactosamine-4-sulfatase, lysosomal
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_0fc6cd44_7058_40ce_ad25_d5143ce843fe
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: P35557
is encoded by: hsa:2645
name: GCK
initial concentration: NaN
constant: false

metaM lgnc e
is: CHEBI:31014
initial amount: NaN
is: HMDB02003
is: SBO:0000247
notes: FORMULA: C24H47O2 CHARGE: -1 INCHI: InChI=1S/C24H48O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h2-23H2,1H3,(H,25,26)/p-1 HEPATONET_1.0_ABBREVIATION: HC01788 EHMN_ABBREVIATION: CE2547
name: lignocerate
initial concentration: 1.0
type: Species
constant: false
boundary condition: false
has only substance units: false

metaM ksii core2 l
is: HMDB01644
type: Species
name: keratan sulfate II (core 2-linked)
initial concentration: 1.0
is: CHEBI:17140
notes: FORMULA: C81H129N6O67S3X CHARGE: -4
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
has only substance units: false

metaR C162OHc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxy hexadecadienoyl carnitine
type: Reaction

metaM dcamp c
is: SBO:0000247
is: HMDB00536
initial amount: NaN
notes: FORMULA: C14H14N5O11P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01183 EHMN_ABBREVIATION: C03794
initial concentration: 1.0
name: N6-(1,2-Dicarboxyethyl)-AMP
type: Species
has only substance units: false
constant: false
boundary condition: false
is: C03794
is: CHEBI:57567

metaR r1627
kinetic law: MODEL1310110001#
type: Reaction
fast: false
reversible: true
product: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185

metaR EX taur LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Taurine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_b6910965_810b_4f53_9637_a1ccd6a69cb8
name: ADHFE1
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:137872
has only substance units: false
constant: false
initial amount: NaN
is: Q8IWW8

http://identifiers.org/biomodels.db/MODEL1310110001#_5b9dff89_7f3d_4fb7_ba34_5e281fe4c03a
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: SOD1
boundary condition: true
constant: false
is encoded by: hsa:6647
is: P00441
type: Species
initial concentration: NaN

metaM HC01459 x
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:27458
notes: FORMULA: C48H76N7O21P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O21P3S/c1-24(28-8-9-29-36-30(19-34(59)48(28,29)6)47(5)13-11-27(56)17-26(47)18-32(36)58)7-10-31(57)25(2)45(64)80-16-15-50-35(60)12-14-51-43(63)40(62)46(3,4)21-73-79(70,71)76-78(68,69)72-20-33-39(75-77(65,66)67)38(61)44(74-33)55-23-54-37-41(49)52-22-53-42(37)55/h22-34,36,38-40,44,56-59,61-62H,7-21H2,1-6H3,(H,50,60)(H,51,63)(H,68,69)(H,70,71)(H2,49,52,53)(H2,65,66,67)/t24-,25?,26+,27-,28-,29+,30+,31?,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 EHMN_ABBREVIATION: C05450
type: Species
initial amount: NaN
name: 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA
constant: false
has only substance units: false

metaR ASPTA
reversible: true
kinetic law: MODEL1310110001#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.6.1.1
modifier: MODEL1310110001#
name: aspartate transaminase
notes: GENE_ASSOCIATION: (2805.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 2.6.1.1 Confidence Level: 4 AUTHORS: PMID:2225456,PMID:6930651 NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction

metaM xoltriol c
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
notes: FORMULA: C27H48O3 CHARGE: 0 INCHI: InChI=1S/C27H48O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h16-25,28-30H,6-15H2,1-5H3/t17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01463 EHMN_ABBREVIATION: C05454
name: 5beta-cholestane-3alpha,7alpha,12alpha-triol
initial concentration: 1.0
is: HMDB01457
is: CHEBI:16496
type: Species
boundary condition: false

metaM HC02208 c
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-18,21-22H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,18-/m0/s1
name: prostaglandin-d1
is: CHEBI:27696
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_b1828f8c_15d8_4d61_8d3d_be553f35d145
constant: false
has only substance units: false
name: _N63787_1_c
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:N63787

metaR PPItm
fast: false
product: MODEL1310110001#
type: Reaction
reversible: true
reactant: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000134
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. NOTES:added during gap-filling.
name: diphopshate transporter, mitochondrial

metaR RE1254C
name: RE1254
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: 1.14.17.1 Confidence Level: 0 AUTHORS: PMID:3443096,PMID:7759508,PMID:9763470 NOTES:
is: SBO:0000176
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_03b1bb63_e429_4d8e_ae9d_d9a49f9aca01
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
name: _AL048840_1_c
type: Species
is encoded by: hsa:AL048840
constant: false
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_d0137418_89ea_4e3d_a550_594a2531016c
has only substance units: false
boundary condition: true
type: Species
is: SBO:0000252
constant: false
is encoded by: hsa:1491
initial amount: NaN
is: P32929
name: CTH
initial concentration: NaN

metaR r1628
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110001#
is: SBO:0000185
kinetic law: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110001#
type: Reaction
reversible: true

metaR MECOAS1m
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:IF
is version of: http://identifiers.org/ec-code/6.2.1.4
name: mesaconate--CoA ligase (GDP-forming)
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
type: Reaction
product: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000304
fast: false
modifier: MODEL1310110001#

metaM fmn e
initial concentration: 1.0
initial amount: NaN
constant: false
is: C00061
type: Species
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB01520
is: CHEBI:58210
notes: FORMULA: C17H19N4O9P CHARGE: -2
name: FMN

http://identifiers.org/biomodels.db/MODEL1310110001#_f6187550_95a6_467b_9094_ae1baebe11de
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: FOLR1
is encoded by: hsa:2348
initial amount: NaN
has only substance units: false
type: Species

metaR ME2m
reversible: false
reactant: MODEL1310110001#
name: malic enzyme (NADP), mitochondrial
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.38
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.40 Confidence Level: 0 AUTHORS: PMID:1993674 NOTES:IF
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.40
type: Reaction
modifier: MODEL1310110001#
fast: false
product: MODEL1310110001#
is described by: ECO:0000000

metaM dec47dicoa m
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
initial amount: NaN
name: 4,7-decadienoylcoa
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false

metaR GNDer
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.44 Confidence Level: 4 AUTHORS: PMID:2156506 NOTES:SMP Note no proton generation by the the reaction NCD
type: Reaction
reversible: false
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176
fast: false
name: phosphogluconate dehydrogenase, endoplasmic reticulum

http://identifiers.org/biomodels.db/MODEL1310110001#_bfc018a4_29ba_416f_ab5c_5566f5550449
name: HMGCS1
is encoded by: hsa:3157
initial amount: NaN
is: Q01581
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN

metaR r1512
type: Reaction
fast: false
name: Utilized transport
reversible: false
reactant: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_a0ccaa44_8a8a_4f31_a221_3fd60aa9e1f3
boundary condition: true
type: Species
is encoded by: hsa:10195
is: SBO:0000252
has only substance units: false
initial amount: NaN
name: ALG3
constant: false
initial concentration: NaN

metaR RIBt
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000185
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
fast: false
name: ribose transport via diffusion
reversible: true
product: MODEL1310110001#

metaR FAOXC184C163m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation (C18:4-->C16:3)m
type: Reaction

metaM 3hbcoa R c
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
constant: false
is: HMDB01166
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14-,18-,19-,20+,24-/m1/s1
initial concentration: 1.0
has only substance units: false
name: (R)-3-hydroxybutanoyl-CoA(4-)

http://identifiers.org/biomodels.db/MODEL1310110001#_d96b44e6_f5e1_4d4d_9268_efaef1e8df68
initial concentration: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:2194
type: Species
initial amount: NaN
name: FASN
has only substance units: false
is: P49327
boundary condition: true

metaR FAOXC123C102x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12:3-->C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_88d27507_7ec8_4ec1_923e_31fabc3d329a
initial concentration: NaN
is: SBO:0000252
is: Q9ULC5
name: ACSL5
has only substance units: false
type: Species
boundary condition: true
is encoded by: hsa:51703
initial amount: NaN
constant: false

metaM fgam c
initial concentration: 1.0
notes: FORMULA: C8H13N2O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01281 EHMN_ABBREVIATION: C04376
initial amount: NaN
has only substance units: false
type: Species
is: C04376
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
is: CHEBI:58426
boundary condition: false
is: HMDB01308
is: SBO:0000247
constant: false

metaM fmn c
initial amount: NaN
boundary condition: false
constant: false
has only substance units: false
is: C00061
is: SBO:0000247
notes: FORMULA: C17H19N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00064 EHMN_ABBREVIATION: C00061
is: CHEBI:58210
is: HMDB01520
initial concentration: 1.0
type: Species
name: FMN

metaR C6DCCACT
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of adipoyl carnitine into cytosol
type: Reaction

metaM hista c
is: CHEBI:58432
is: HMDB00870
initial amount: NaN
boundary condition: false
constant: false
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
type: Species
initial concentration: 1.0
name: histamium
has only substance units: false
is: SBO:0000247

metaM focytC m
constant: false
has only substance units: false
boundary condition: false
initial amount: NaN
name: Ferrocytochrome C
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16928
notes: FORMULA: C42H54FeN8O6S2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00124

metaR r1956
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110001#
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110001#
reversible: false
type: Reaction
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000

metaR ADSK
type: Reaction
reactant: MODEL1310110001#
name: adenylyl-sulfate kinase
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.25 Confidence Level: 4 AUTHORS: PMID:11931637,PMID:12716056 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.25
fast: false
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
reversible: false
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110001#

metaR r0242
reactant: MODEL1310110001#
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
name: Glycerone phosphate phosphohydrolase (alkaline optimum) EC:3.1.3.1
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.1
product: MODEL1310110001#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (84532.1) or (55902.1) or (79611.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.1 Confidence Level: 0 AUTHORS: PMID:1730777,PMID:3042787 NOTES:

metaR FAOXC204184m
reversible: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.8.1
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: Beta oxidation fatty acid
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.99.3
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 rounds of beta ox c20:4 -> c18:4 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction

metaR EX ddecrn
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for lauroyl carnitine
type: Reaction

metaR NACHEXA21ly
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110001#
product: MODEL1310110001#
reversible: false
fast: false
is: SBO:0000176
kinetic law: MODEL1310110001#
name: beta-N-acetylhexosaminidase A, lysosomal
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:Note that this reaction is specific to beta-N-acetylhexosaminidase A and cannot be catalyzed by beta-N-acetylhexosaminidase B (or presumably beta-N-acetylhexosaminidase S). This is also a lumped reaction, representing the cleavage of GalNAc4S or GalNAc6S and N-acetylgalactosamine 4-sulfatase or 6-sulfatase. NCD

metaM 4abut n
has only substance units: false
notes: FORMULA: C4H9NO2 CHARGE: 0
is: SBO:0000247
constant: false
initial concentration: 1.0
is: HMDB00112
is: C00334
name: 4-Aminobutanoate
type: Species
initial amount: NaN
boundary condition: false

metaR DASCBR
modifier: MODEL1310110001#
is described by: ECO:0000269
name: dehydroascorbate reductase
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: false
is: SBO:0000176
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (2745.1) or (51022.2) or (51022.1) SUBSYSTEM: Vitamin C metabolism EC Number: 1.6.5.4 Confidence Level: 4 AUTHORS: PMID:11297543 NOTES:
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.8.4.1

metaR r2140
fast: false
is: SBO:0000185
reversible: true
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
modifier: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#

metaR EX chol LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Choline
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_7d55a6c2_4741_474f_866a_823569717583
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: SULT2B1
initial amount: NaN
constant: false
is encoded by: hsa:6820
type: Species

metaR ITCOAL1m
name: Itaconate--CoA ligase (GDP-forming), mitochondrial
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: C5-branched dibasic acid metabolism EC Number: 6.2.1.4 Confidence Level: 2 AUTHORS: PMID:13783048 NOTES:NCD
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.2.1.4
product: MODEL1310110001#
is: SBO:0000176
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110001#_899ae0b7_4d9c_4717_9df9_700a56df34d9
boundary condition: true
name: _AI656480_1_m
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AI656480
constant: false
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_025dc5ec_e664_4631_98ce_13c01bf5740b
name: SLC23A2
constant: false
type: Species
is encoded by: hsa:9962
initial concentration: NaN
is: Q9UGH3
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN

metaM hdd2crn c
is: SBO:0000247
is: HMDB06317
constant: false
type: Species
name: trans-Hexadec-2-enoyl carnitine
initial amount: NaN
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h17-18,21H,5-16,19-20H2,1-4H3/b18-17+
boundary condition: false
has only substance units: false
initial concentration: 1.0

metaR CYTK9n
modifier: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (CMP,dCTP),nuclear
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
is described by: ECO:0000269
is: SBO:0000176

metaM tdcoa c
type: Species
notes: FORMULA: C35H58N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00971 EHMN_ABBREVIATION: C02593
has only substance units: false
constant: false
is: SBO:0000247
is: C02593
is: CHEBI:57385
initial concentration: 1.0
initial amount: NaN
name: Tetradecanoyl-CoA (n-C14:0CoA)
is: HMDB01521
boundary condition: false

metaR DRPA
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.2.4 Confidence Level: 2 AUTHORS: NOTES:
product: MODEL1310110001#
name: deoxyribose-phosphate aldolase
fast: false

metaR GALASE7ly
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
product: MODEL1310110001#
reversible: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
name: beta-galactosidase, lysosomal
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5

metaR 2AMACSULT
is described by: ECO:0000000
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220,PMID:6351723 NOTES:-this is a lumped rxn w/ an inferred reduction rxn that occurs in conjunction w/ sulfotransferase step; this reduction step has to occur in order for the transformation (2amac-->Lcyst) to be valid -used NADPH as electron donor since it is a common cofactor involved in biosynthetic steps utilizing oxygen (see Neema for further explanations) MM
is: SBO:0000176
name: 2-Aminoacrylate sulfotransferase
product: MODEL1310110001#
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_b4c0bcb6_2841_48e6_af4d_00462d645e6f
is: SBO:0000252
name: SLC9A1
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
initial amount: NaN
type: Species
is encoded by: hsa:6548
is: P19634

metaR r2141
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
fast: false
product: MODEL1310110001#
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000185
kinetic law: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR TYRt
name: L-tyrosine transport
modifier: MODEL1310110001#
fast: false
is: SBO:0000185
reactant: MODEL1310110001#
type: Reaction
reversible: true
kinetic law: MODEL1310110001#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (117247.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11827462 NOTES:
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_536025c9_941c_49ae_ab84_05480cebe0e5
is: A8K0I1
is encoded by: hsa:160851
is: SBO:0000252
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species
name: DGKH
initial concentration: NaN

metaM dpcoa c
type: Species
is: C00882
is: SBO:0000247
has only substance units: false
boundary condition: false
name: Dephospho-CoA
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C21H33N7O13P2S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00575 EHMN_ABBREVIATION: C00882
constant: false
is: HMDB01373
is: CHEBI:57328

http://identifiers.org/biomodels.db/MODEL1310110001#_83cfa702_aa1d_4698_a6f5_41920650ea39
is encoded by: hsa:4668
type: Species
initial concentration: NaN
is: P17050
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
name: NAGA

metaM mn l
name: beta-1,4-mannose-N-acetylglucosamine
boundary condition: false
constant: false
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB06535
is: SBO:0000247
type: Species
notes: FORMULA: C14H25NO11 CHARGE: 0 INCHI: InChI=1/C14H25NO11/c1-4(18)15-7-9(20)12(6(3-17)24-13(7)23)26-14-11(22)10(21)8(19)5(2-16)25-14/h5-14,16-17,19-23H,2-3H2,1H3,(H,15,18)/t5-,6-,7-,8-,9-,10+,11+,12-,13-,14-/m1/s1

metaM CE2422 m
is: CHEBI:28387
is: HMDB11123
boundary condition: false
constant: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C37H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C37H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-25(45)20-28(47)66-19-18-39-27(46)16-17-40-35(50)32(49)37(2,3)22-59-65(56,57)62-64(54,55)58-21-26-31(61-63(51,52)53)30(48)36(60-26)44-24-43-29-33(38)41-23-42-34(29)44/h8-9,11-12,23-24,26,30-32,36,48-49H,4-7,10,13-22H2,1-3H3,(H,39,46)(H,40,50)(H,54,55)(H,56,57)(H2,38,41,42)(H2,51,52,53)/p-4/b9-8-,12-11-/t26-,30+,31+,32u,36-/m0/s1 EHMN_ABBREVIATION: CE2422
name: 3-oxo-cis,cis-7,10-hexadecadienoyl-CoA

metaM hista e
has only substance units: false
is: HMDB00870
is: CHEBI:58432
initial amount: NaN
constant: false
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C5H10N3 CHARGE: 1 INCHI: InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)/p+1 HEPATONET_1.0_ABBREVIATION: HC00323 EHMN_ABBREVIATION: C00388
is: SBO:0000247
name: histamium

metaR FAOXC164C165m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)m
type: Reaction

metaM dolglcp L r
has only substance units: false
is: SBO:0000247
is: CHEBI:15812
initial concentration: 1.0
constant: false
notes: FORMULA: C1140H1868O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30-,31+/m1/s1
type: Species
boundary condition: false
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog
initial amount: NaN

metaM retfa c
constant: false
is: CHEBI:50211
is: SBO:0000247
boundary condition: false
has only substance units: false
notes: FORMULA: C20H29OFULLR2CO CHARGE: 0
initial amount: NaN
type: Species
name: fatty acid retinol
is: HMDB00305
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_c2057ed0_c5ff_42e5_abde_6efbeacd3c1a
initial amount: NaN
constant: false
is encoded by: hsa:8801
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
boundary condition: true
is: Q96I99
name: SUCLG2

http://identifiers.org/biomodels.db/MODEL1310110001#_dbe87c39_5fc5_49da_a87a_4454dc485914
is: SBO:0000252
constant: false
is: P11177
boundary condition: true
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: PDHB
is encoded by: hsa:5162

http://identifiers.org/biomodels.db/MODEL1310110001#_f87f92cb_fe53_4733_9244_f02770013c5a
type: Species
name: AUH
is: SBO:0000252
is: Q13825
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is encoded by: hsa:549
initial concentration: NaN

metaR r0683
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Unassigned EC Number: 1.3.99.3 Confidence Level: 0 AUTHORS: PMID:10502673,PMID:3597357,PMID:4062874 NOTES:
is described by: ECO:0000000
product: MODEL1310110001#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
name: Propanoyl-CoA:(acceptor) 2,3-oxidoreductase beta-Alanine metabolism EC:1.3.3.6 EC:1.3.99.3
reversible: false
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176

metaM 3uib c
is: CHEBI:1670
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C5H9N2O3 CHARGE: -1 INCHI: InChI=1S/C5H10N2O3/c1-3(4(8)9)2-7-5(6)10/h3H,2H2,1H3,(H,8,9)(H3,6,7,10) HEPATONET_1.0_ABBREVIATION: HC01371 EHMN_ABBREVIATION: C05100
has only substance units: false
is: HMDB02031
name: 3-Ureidoisobutyrate
initial concentration: 1.0
type: Species
boundary condition: false

metaM ksi deg25 l
is: SBO:0000247
notes: FORMULA: C118H192N8O98S4 CHARGE: -4
constant: false
type: Species
name: keratan sulfate I, degradation product 25
initial concentration: 1.0
is: HMDB01354
boundary condition: false
is: CHEBI:57455
initial amount: NaN
has only substance units: false

metaR GALASE6ly
is: SBO:0000176
name: beta-galactosidase, lysosomal
modifier: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
reversible: false
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.2.1.23
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110001#_33a10faf_fc49_4e63_a639_45dd97cd72aa
constant: false
type: Species
name: ST3GAL2
is: Q16842
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6483
has only substance units: false
initial amount: NaN

metaR DTTPtn
product: MODEL1310110001#
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
name: dTTP diffusion in nucleus
reversible: true

metaR EX idour LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-iduronate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_c7e0fcb3_4b4d_41bd_b8e1_3b0778b88c2c
has only substance units: false
name: NDUFS5
is: Q6IBA0
type: Species
is encoded by: hsa:4725
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN

metaM fald c
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:16842
has only substance units: false
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: CH2O CHARGE: 0 INCHI: InChI=1S/CH2O/c1-2/h1H2 HEPATONET_1.0_ABBREVIATION: HC00070 EHMN_ABBREVIATION: C00067
name: formaldehyde
is: HMDB01426

metaM nm4masn g
is: SBO:0000247
notes: FORMULA: C54H90N3O40X CHARGE: 0
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: C05882
boundary condition: false

metaR FUMSO3tm
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
fast: false
modifier: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
type: Reaction
name: Fumarate:sulfite antiport, mitochondrial
is described by: ECO:0000269

metaR SIAASE3ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000
product: MODEL1310110001#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110001#
name: sialidase, lysosomal
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.18
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
fast: false

metaM cs a l
type: Species
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain
is: CHEBI:36005
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB02183
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C45H67N2O46S3 CHARGE: -5

metaM ps hs m
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
is: CHEBI:18303
name: ps_hs[m]
type: Species
boundary condition: false
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0

metaR CHOLtn
name: Choline transport, nuclear through pores
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:it
fast: false
kinetic law: MODEL1310110001#
type: Reaction

metaM 3mox4hoxm m
notes: FORMULA: C9H9O5 CHARGE: -1 INCHI: InChI=1S/C9H10O5/c1-14-7-4-5(2-3-6(7)10)8(11)9(12)13/h2-4,8,10-11H,1H3,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC01521 EHMN_ABBREVIATION: C05584
constant: false
is: HMDB00291
has only substance units: false
initial concentration: 1.0
name: 3-Methoxy-4-hydroxymandelate
type: Species
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: CHEBI:27622

metaR HMBS
kinetic law: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3145.1) SUBSYSTEM: Heme synthesis EC Number: 4.3.1.8 Confidence Level: 2 AUTHORS: PMID:2875434 NOTES:
reactant: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#
fast: false
name: hydroxymethylbilane synthase
product: MODEL1310110001#
type: Reaction
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.5.1.61

http://identifiers.org/biomodels.db/MODEL1310110001#_6b51563d_e73c_47cb_95f6_560a166487d9
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:84920
is: Q5BKT4
initial amount: NaN
type: Species
name: ALG10
is: SBO:0000252
boundary condition: true

metaR EX Rtotal2 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: R total 2 position exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_8eae1ab8_cb34_448b_989c_0d797bdb9972
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: B7Z3U6
constant: false
name: ATP1A1
is encoded by: hsa:476
is: SBO:0000252
has only substance units: false
type: Species

metaR r0686
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (AI222095.1) or (AI697028.1) or (D87002.1) or (2678.1) or (728441.1) or (2687.1) or (2686.1) or (728226.1) or (NM_013421.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 0 AUTHORS: PMID:1286669,PMID:2211729 NOTES:
product: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.2.2
name: L-1-Pyrroline-3-hydroxy-5-carboxylate:NADP+ oxidoreductase Arginine and proline metabolism EC:1.5.1.12
kinetic law: MODEL1310110001#
is: SBO:0000176
reversible: true

metaR RE0935E
is version of: http://identifiers.org/ec-code/3.2.1.17
is described by: ECO:0000000
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.1
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
fast: false
product: MODEL1310110001#
reversible: true
name: RE0935
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110001#

metaR CERT2gt
is version of: http://identifiers.org/ec-code/2.7.11.1
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of glucocerebroside
is: SBO:0000185
type: Reaction
name: ceramide transport protein
is described by: ECO:0000000
modifier: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
product: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#

metaR CYTK4n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176
modifier: MODEL1310110001#
product: MODEL1310110001#
reversible: true
fast: false
reactant: MODEL1310110001#
name: cytidylate kinase (dCMP,GTP),nuclear
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR GLNLASEer
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin C metabolism EC Number: 3.1.1.17 Confidence Level: 2 AUTHORS: PMID:9296457 NOTES:NCD
kinetic law: MODEL1310110001#
fast: false
reversible: true
name: gluconolactonase, endoplasmic reticulum
product: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
is described by: ECO:0000000

metaR PRGNLONESULT
reactant: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.14
fast: false
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (6822.1) or (6820.2) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:12145317,PMID:9799594 NOTES:NJ
product: MODEL1310110001#
reversible: false
name: steroid sulfotransferase
is: SBO:0000176
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.8.2.2

http://identifiers.org/biomodels.db/MODEL1310110001#_94a9ab78_1f2e_4329_931e_1656ad4ff7a2
initial amount: NaN
constant: false
initial concentration: NaN
has only substance units: false
is: Q8TD20
boundary condition: true
is: SBO:0000252
is encoded by: hsa:154091
name: SLC2A12
type: Species

metaR PPCOACm
modifier: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
reversible: false
is version of: http://identifiers.org/ec-code/6.4.1.3
product: MODEL1310110001#
is described by: ECO:0000269
is: SBO:0000176
name: Propionyl-CoA carboxylase, mitochondrial
notes: GENE_ASSOCIATION: (5096.1 and 5095.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 6.4.1.3 Confidence Level: 4 AUTHORS: PMID:3460076,PMID:8188292 NOTES:TV

http://identifiers.org/biomodels.db/MODEL1310110001#_36b8ccd7_1045_40a7_ad42_6fbd8645afd3
boundary condition: true
name: SULT1A3
constant: false
is: Q1ET61
is encoded by: hsa:6818
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is: SBO:0000252

metaR GLYCt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9405233 NOTES:NCD
reactant: MODEL1310110001#
product: MODEL1310110001#
fast: false
name: glycerol transport via channel
reversible: true
type: Reaction
kinetic law: MODEL1310110001#
is described by: ECO:0000000

metaM cdp n
initial concentration: 1.0
is: CHEBI:58069
constant: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546
boundary condition: false
is: SBO:0000247
has only substance units: false
name: CDP(3-)
initial amount: NaN
type: Species

metaR r2322
product: MODEL1310110001#
reversible: true
is: SBO:0000185
reactant: MODEL1310110001#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110001#

metaR AG13T6g
type: Reaction
is: SBO:0000176
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
modifier: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.149

metaM prist x
boundary condition: false
type: Species
initial amount: NaN
constant: false
is: HMDB00795
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
is: CHEBI:51340
name: pristanic acid
has only substance units: false
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_9cdbf192_42aa_452e_9298_10828f6538ce
constant: false
boundary condition: true
type: Species
initial concentration: NaN
is: SBO:0000252
is: Q5MY95
initial amount: NaN
has only substance units: false
name: ENTPD8
is encoded by: hsa:377841

metaM Lkynr c
name: L-kynurenine
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: HMDB00684
type: Species
boundary condition: false
constant: false
is: CHEBI:16946
has only substance units: false
notes: FORMULA: C10H12N2O3 CHARGE: 0 INCHI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00278 EHMN_ABBREVIATION: C00328

metaR r0016
kinetic law: MODEL1310110001#
product: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (1356.1) or (2495.1) or (2509.1) or (94033.1) or (84343.1) SUBSYSTEM: Miscellaneous EC Number: 1.16.3.1 Confidence Level: 0 AUTHORS: PMID:16405854,PMID:2154449,PMID:9162052,PMID:9722559 NOTES:
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.16.3.1
type: Reaction
is described by: ECO:0000000
name: Fe(II):oxygen oxidoreductase Porphyrin and chlorophyll metabolism EC:1.16.3.1
is: SBO:0000176
reversible: true

metaR IDPtn
kinetic law: MODEL1310110001#
fast: false
name: IDP nuclear transport
is: SBO:0000185
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
reversible: true
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_374e4ecf_a42f_4cb3_982e_e4a02dcdcc56
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:6515
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
name: SLC2A3
is: P11169

metaR r0173
kinetic law: MODEL1310110001#
name: (S)-Lactate:NAD+ oxidoreductase Glycolysis / Gluconeogenesis / Pyruvate metabolism EC:1.1.1.27
reversible: true
modifier: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (3704.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.1.1.27 Confidence Level: 0 AUTHORS: PMID:12042361,PMID:17045662,PMID:7449128,PMID:9927705 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.19
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000

metaR C18OHc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecanoylcarnitine
type: Reaction

metaM biocyt e
is: http://identifiers.org/pubchem.compound/7886
boundary condition: false
initial amount: NaN
is: HMDB03134
name: Biocytin
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
is: SBO:0000247
is: C05552
has only substance units: false

metaR ATPtx
reactant: MODEL1310110001#
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:most likely NOT physiological - detailed information about the peroxisomal transporters has not yet been achieved - this transport is most likely dependent on a concomitant energy consuming reaction (human ABC peroxisomal transporters: PEX family - check in future for new research articles describing biochemistry and stoichiometry) NJ
name: ATP transporter, peroxisomal

metaR FAOXC225C204m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)m
type: Reaction

metaM 5aop c
initial amount: NaN
is: CHEBI:17549
constant: false
is: SBO:0000247
is: C00430
type: Species
is: HMDB01149
initial concentration: 1.0
name: 5-Amino-4-oxopentanoate
boundary condition: false
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00349 EHMN_ABBREVIATION: C00430

http://identifiers.org/biomodels.db/MODEL1310110001#_580c1223_6d15_40a5_92be_8d74d6bf7793
type: Species
name: IK
constant: false
boundary condition: true
is encoded by: hsa:3550
has only substance units: false
is: Q13123
is: SBO:0000252
initial concentration: NaN
initial amount: NaN

metaM cdp m
initial amount: NaN
is: HMDB01546
type: Species
boundary condition: false
constant: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58069
name: CDP(3-)

metaR r2323
reactant: MODEL1310110001#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reversible: true
kinetic law: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
product: MODEL1310110001#
is: SBO:0000185

metaR DM gncore2 g
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM gncore2(g)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_b85096a9_d718_4435_a9e0_5f84254fae29
is: SBO:0000252
constant: false
is encoded by: hsa:5152
name: PDE9A
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_e27e535d_82b9_48ee_9323_a473ca0367b1
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
is encoded by: hsa:55343
is: B3KQH0
initial concentration: NaN
name: SLC35C1

http://identifiers.org/biomodels.db/MODEL1310110001#_cc600ef2_da7f_45a4_9d89_0261c6ce9b6e
initial amount: NaN
constant: false
name: _U37519_1_m
is: SBO:0000252
is encoded by: hsa:U37519
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_17c81e39_9e5f_4933_a2cc_92727899820e
initial amount: NaN
boundary condition: true
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:4190
type: Species
name: MDH1
is: B7Z3I7
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_8f4d9804_642b_4654_b0d5_739de7400f32
initial concentration: NaN
name: BLVRA
initial amount: NaN
has only substance units: false
constant: false
is: P53004
boundary condition: true
is encoded by: hsa:644
type: Species
is: SBO:0000252

metaM chito2pdol L c
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:12427
boundary condition: false
type: Species
notes: FORMULA: C1240H2028N20O170P20 CHARGE: -20 INCHI: InChI=1S/C41H72N2O17P2/c1-25(2)13-9-14-26(3)15-10-16-27(4)17-11-18-28(5)19-12-20-29(6)21-22-55-61(51,52)60-62(53,54)59-41-35(43-31(8)47)38(50)39(33(24-45)57-41)58-40-34(42-30(7)46)37(49)36(48)32(23-44)56-40/h13,15,17,19,29,32-41,44-45,48-50H,9-12,14,16,18,20-24H2,1-8H3,(H,42,46)(H,43,47)(H,51,52)(H,53,54)/b26-15+,27-17+,28-19-/t29?,32-,33-,34-,35-,36-,37-,38-,39-,40+,41-/m1/s1
is: HMDB01196
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog

metaM dolp L c
constant: false
is: SBO:0000247
type: Species
name: dolichyl phosphate(2-)
has only substance units: false
is: CHEBI:57683
boundary condition: false
initial amount: NaN
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
initial concentration: 1.0

metaM c226coa c
has only substance units: false
is: http://identifiers.org/pubchem.compound/47205479
initial amount: NaN
constant: false
is: C16169
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A
type: Species

metaR ACACT5p
modifier: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (30.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 4 AUTHORS: PMID:1679347 NOTES:NCD
fast: false
is: SBO:0000176
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.16
is described by: ECO:0000269
reversible: false
reactant: MODEL1310110001#
name: acetyl-CoA C-acyltransferase (decanoyl-CoA), peroxisomal
kinetic law: MODEL1310110001#

metaM hs deg22 l
is: HMDB02704
initial concentration: 1.0
initial amount: NaN
name: IdoA-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247
is: CHEBI:21338
notes: FORMULA: C37H56NO35S CHARGE: -3
boundary condition: false
constant: false
has only substance units: false
type: Species

metaR ADRNCPT2
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
reversible: false
product: MODEL1310110001#
type: Reaction
name: carnitine transferase
is: SBO:0000176
fast: false

metaR r0680
modifier: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.137
type: Reaction
fast: false
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI373818.1) or (54677.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_2f69bf2f_ca41_4b1d_a937_81065202aa95
name: GPAA1
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: O43292
is encoded by: hsa:8733
type: Species
boundary condition: true

metaR ACGPID
name: N-acetylglucosaminylphosphatidylinositol deacetylase
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.5.1.89
type: Reaction
kinetic law: MODEL1310110001#
fast: false
product: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (9487.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: 3.5.1.89 Confidence Level: 4 AUTHORS: PMID:10085243,PMID:14742432 NOTES:NCD
reactant: MODEL1310110001#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110001#_c9c31982_3a29_473a_8be8_86d7f849af08
initial amount: NaN
type: Species
name: ALDH7A1
is: E7EPT3
is: SBO:0000252
is encoded by: hsa:501
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_c2f7318e_e348_4bf7_b63c_6abe9c074926
initial amount: NaN
has only substance units: false
name: FDPS
boundary condition: true
is: P14324
type: Species
is encoded by: hsa:2224
constant: false
is: SBO:0000252
initial concentration: NaN

metaR r2320
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110001#
is: SBO:0000185
reactant: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
is described by: ECO:0000000
type: Reaction

metaM stcoa m
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: C00412
name: Stearoyl-CoA (n-C18:0CoA)
is: HMDB01114
constant: false
is: CHEBI:57394

metaR FAOXC225C226x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)x
type: Reaction

metaR FAOXTC182TC162m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C18:2-->C16:2)m
type: Reaction

metaR ADRNCPT1
reactant: MODEL1310110001#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
name: carnitine O-palmitoyltransferase
reversible: false
is: SBO:0000176
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

metaR FAOXC24C22x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: Fatty acid beta oxidation(C24-->C22)x
type: Reaction

metaM biocyt c
is: HMDB03134
is: http://identifiers.org/pubchem.compound/7886
has only substance units: false
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
name: Biocytin
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
is: C05552
boundary condition: false
is: SBO:0000247

metaM malcoa c
name: Malonyl-CoA
initial concentration: 1.0
is: CHEBI:57384
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
is: HMDB01175
type: Species
has only substance units: false
is: C00083
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN

metaR GDPtg
reversible: true
kinetic law: MODEL1310110001#
is: SBO:0000185
reactant: MODEL1310110001#
fast: false
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - likely translocated, unknown transporter/mechanism though NJ
product: MODEL1310110001#
name: GDP intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110001#_0bde0f5e_3536_4d81_92b8_7ac642248143
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
constant: false
is: O94903
is encoded by: hsa:11212
is: SBO:0000252
initial concentration: NaN
name: PROSC

http://identifiers.org/biomodels.db/MODEL1310110001#_d3fef2e9_ceae_40c3_8308_f36ad1efd1ce
is: P38571
name: LIPA
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:3988
has only substance units: false

metaR EX glyc LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Glycerol exchange
type: Reaction

metaR r2321
is described by: ECO:0000000
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
fast: false
is: SBO:0000185
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
product: MODEL1310110001#

metaR ECOAH9m
product: MODEL1310110001#
is: SBO:0000176
type: Reaction
reactant: MODEL1310110001#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 2-Methylprop-2-enoyl-CoA (2-Methylbut-2-enoyl-CoA), mitochondrial
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
reversible: true
fast: false
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM sebacid x
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H16O4 CHARGE: -2
type: Species
is: C08277
boundary condition: false
name: sebacicacid
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00792

metaR S6TASE18ly
is: SBO:0000176
kinetic law: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/3.1.6.14
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
name: N-acetylglucosamine-6-sulfatase, lysosomal
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110001#
reversible: true

metaM ksii core4 pre2 g
initial amount: NaN
is: SBO:0000247
type: Species
has only substance units: false
is: C00130
name: keratan sulfate II boisynthesis, precursor 2
constant: false
notes: FORMULA: C47H76N4O33X CHARGE: -1
initial concentration: 1.0
is: HMDB00175
is: CHEBI:58053
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_36457cfc_7389_40e5_9060_a23c04730e63
is: SBO:0000252
name: LEFTY1
boundary condition: true
is encoded by: hsa:10637
initial amount: NaN
type: Species
is: O75610
initial concentration: NaN
has only substance units: false
constant: false

metaR ACP1 FMN
modifier: MODEL1310110001#
reversible: false
is: SBO:0000176
is described by: ECO:0000254
type: Reaction
kinetic law: MODEL1310110001#
fast: false
name: acid phosphatase (FMN)
reactant: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) SUBSYSTEM: Vitamin B2 metabolism EC Number: 3.1.3.2 Confidence Level: 2 AUTHORS: PMID:8522318 NOTES:INVALID ECO TERM: IFH
is version of: http://identifiers.org/ec-code/3.1.3.2

metaR GALASE10ly
is: SBO:0000176
type: Reaction
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.23
reversible: false
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.6.4
is described by: ECO:0000000
fast: false
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
kinetic law: MODEL1310110001#

metaR r0170
type: Reaction
reactant: MODEL1310110001#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
reversible: true
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.1.40
name: Farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:11108725,PMID:1527001,PMID:17180682,PMID:7864626,PMID:8509416 NOTES:

metaR 5OXPROt
is described by: ECO:0000134
reactant: MODEL1310110001#
reversible: true
name: Transport of 5-oxoprolinate
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
kinetic law: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_46ca8bc9_a271_4265_b987_417fb3058942
is: O43924
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:5147
name: PDE6D
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_24bc3d66_1e2d_4dfc_ac33_5291ee3d4de4
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
constant: false
has only substance units: false
initial concentration: NaN
name: SULT2A1
is: Q06520
is encoded by: hsa:6822

http://identifiers.org/biomodels.db/MODEL1310110001#_95f451d1_f285_46d4_b0d8_e40070a4cce9
initial amount: NaN
initial concentration: NaN
has only substance units: false
is encoded by: hsa:80025
type: Species
boundary condition: true
constant: false
name: PANK2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_fa169fa8_217f_4445_9e77_0b97a5f8332e
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:NM 001929
initial amount: NaN
constant: false
has only substance units: false
type: Species
boundary condition: true
name: _NM_001929_1_c

metaR r2326
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
product: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR F1PGT
name: fucose-1-phosphate guanylyltransferase
notes: GENE_ASSOCIATION: (8790.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.7.30 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.7.7.30
kinetic law: MODEL1310110001#
product: MODEL1310110001#
fast: false
is: SBO:0000176
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_a9d9ddf5_dcb4_437f_89ff_bc099314548b
type: Species
initial concentration: NaN
name: EGFR
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
is: P00533
initial amount: NaN
is encoded by: hsa:1956

http://identifiers.org/biomodels.db/MODEL1310110001#_fa39dec9_7fc8_49c1_8033_32ab8ba4d820
name: C1GALT1
initial concentration: NaN
constant: false
is encoded by: hsa:56913
boundary condition: true
is: Q9NS00
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN

metaR r1691
fast: false
modifier: MODEL1310110001#
reversible: false
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185

metaR r0570
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000000
reversible: true
name: 2-Deoxy-D-ribose 1-phosphate 1,5-phosphomutase Pentose phosphate pathway EC:5.4.2.7
fast: false
notes: GENE_ASSOCIATION: (10588.1) or (400410.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 5.4.2.7 Confidence Level: 0 AUTHORS: PMID:3023765 NOTES:
type: Reaction
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.3.3.2

metaR ORETNF
reactant: MODEL1310110001#
reversible: false
fast: false
product: MODEL1310110001#
name: 4-oxo-retinoic acid formation (oxidation)
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
kinetic law: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000176
type: Reaction

metaR FACOAL200
fast: false
reactant: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000269
kinetic law: MODEL1310110001#
product: MODEL1310110001#

metaM idp n
boundary condition: false
initial amount: NaN
is: CHEBI:58280
type: Species
notes: FORMULA: C10H11N4O11P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O11P2/c15-6-4(1-23-27(21,22)25-26(18,19)20)24-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00104 EHMN_ABBREVIATION: C00104
is: HMDB03335
initial concentration: 1.0
constant: false
name: IDP(3-)
is: SBO:0000247
has only substance units: false

metaM Rtotalcoa c
notes: FORMULA: CO2FULLRC21H31N7O15P3S CHARGE: -4
boundary condition: false
initial amount: NaN
name: R total Coenzyme A
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB01448
constant: false
is: CHEBI:16189

metaR SO4tl
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: PMID:10535998,PMID:15607730 NOTES:
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000269
name: Sulfate transport (lysosome)
reversible: true
kinetic law: MODEL1310110001#
is: SBO:0000185
fast: false
type: Reaction

metaM f1a l
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0
name: F1alpha
is: HMDB02917
is: SBO:0000247
boundary condition: false
is: CHEBI:17151
has only substance units: false
notes: FORMULA: C22H37N2O15X CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110001#_43533299_b60c_49b3_8db4_5d9b6ca72baa
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:11136
is: P82251
name: SLC7A9
initial concentration: NaN
constant: false
type: Species

metaM ksi g
constant: false
name: keratan sulfate I
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:17140
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: HMDB01644

http://identifiers.org/biomodels.db/MODEL1310110001#_075eb946_5922_41f0_b170_7a4d84761268
is encoded by: hsa:2618
is: P22102
initial concentration: NaN
is: SBO:0000252
name: GART
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_191169a7_d081_4322_ad3b_eb6aaeb53700
initial concentration: NaN
has only substance units: false
is: B3KNC1
initial amount: NaN
is encoded by: hsa:51733
type: Species
is: SBO:0000252
boundary condition: true
constant: false
name: UPB1

metaR SUCCACT
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: activation of succinate
type: Reaction

metaR r2327
reversible: true
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185

metaM psyl e
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
is: HMDB03402
notes: FORMULA: C9642006H15428700O8667414 CHARGE: 0
has only substance units: false
initial amount: NaN
type: Species
name: psyllium

metaR EX ascb L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Ascorbate exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_f4ad8d87_e9b8_4e1a_ad56_ce60311247a4
initial amount: NaN
constant: false
is encoded by: hsa:79901
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: CYBRD1
is: B4DWD7
initial concentration: NaN

metaR r0571
fast: false
product: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 3.1.2.17 Confidence Level: 0 AUTHORS: PMID:3071714,PMID:6885824 NOTES:
is version of: http://identifiers.org/ec-code/1.5.1.8
name: (S)-Methylmalonyl-CoA hydrolase Propanoate metabolism EC:3.1.2.17
is: SBO:0000176

metaM gsn c
initial amount: NaN
type: Species
is: CHEBI:16750
name: Guanosine
has only substance units: false
initial concentration: 1.0
constant: false
is: SBO:0000247
is: C00387
notes: FORMULA: C10H13N5O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00322 EHMN_ABBREVIATION: C00387
is: HMDB00133
boundary condition: false

metaM dhcholestancoa x
constant: false
is: HMDB02159
initial amount: NaN
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
type: Species
is: CHEBI:15494
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
has only substance units: false
boundary condition: false

metaR URAt
modifier: MODEL1310110001#
product: MODEL1310110001#
name: uracil transport via facilated diffusion
is described by: ECO:0000269
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
fast: false
is: SBO:0000185
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#

metaR F1Atg
name: F1alpha transport (from golgi to lysosome)
reversible: true
kinetic law: MODEL1310110001#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110001#
reactant: MODEL1310110001#

metaR PROSTGE1t
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
reversible: true
reactant: MODEL1310110001#
is: SBO:0000185
modifier: MODEL1310110001#
name: prostaglandin transport via bicarbonate countertransport
type: Reaction

metaR FAOXC150m
name: Beta oxidation of long chain fatty acid (odd chain)
product: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:by extension from even chain lumped FAO - should double-check stoich in future NJ
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.3.99.3
kinetic law: MODEL1310110001#
reversible: false
fast: false
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.8.1
is: SBO:0000176

metaR RE2079R
notes: GENE_ASSOCIATION: SUBSYSTEM: Eicosanoid metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:10200320,PMID:11786541,PMID:8521498,PMID:9755286 NOTES:
product: MODEL1310110001#
name: RE2079
type: Reaction
reversible: true
reactant: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000176

metaR r1540
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12719981 NOTES:
modifier: MODEL1310110001#
name: Neurotransmitter:Sodium Symporter (NSS) TCDB:2.A.22.3.3
is described by: ECO:0000000
kinetic law: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
is: SBO:0000185
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_a5e4d3a5_004c_44e8_a714_4e94cb619db3
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
is: P00568
name: AK1
is encoded by: hsa:203
type: Species

metaR FAOXC225C204x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C20:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_5c7ee78f_2c8c_47cc_a5bb_d95b23a48831
boundary condition: true
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: P25325
is encoded by: hsa:4357
name: MPST
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_ac2e4b1d_ea39_4fa2_bf31_42d91c0d04e4
is encoded by: hsa:522
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
name: ATP5J

metaR r2324
product: MODEL1310110001#
reversible: true
fast: false
is: SBO:0000185
kinetic law: MODEL1310110001#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110001#

metaR VACCCRNt
fast: false
kinetic law: MODEL1310110001#
is described by: ECO:0000269
product: MODEL1310110001#
name: transport into the mitochondria (carnitine)
reactant: MODEL1310110001#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110001#
reversible: false

metaR r2325
is: SBO:0000185
product: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_d9a9e1e1_9372_49b5_8f95_2d75587770c3
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: HCST
is: Q9UBK5
is encoded by: hsa:10870
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_978e49ef_144c_4c9d_9010_fd31a15ce562
name: FPGT
is encoded by: hsa:8790
is: O14772
initial concentration: NaN
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
has only substance units: false

metaM tdchola c
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
is: HMDB00951
name: taurochenodeoxycholate
is: SBO:0000247
is: CHEBI:9407
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false

metaM ksi e
name: keratan sulfate I
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:17268
notes: FORMULA: C247H393N17O213S12X CHARGE: -13
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: HMDB00211

http://identifiers.org/biomodels.db/MODEL1310110001#_c950cf41_051a_4e4e_94f0_0be40c76b9c5
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: DEGS1
is: O15121
is encoded by: hsa:8560
boundary condition: true
constant: false
is: SBO:0000252
type: Species

metaM 3docopencoa x
type: Species
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/24892790
boundary condition: false
is: SBO:0000247
constant: false
name: 3,7,10,13,16-docosapentenoylcoa
initial concentration: 1.0
initial amount: NaN
has only substance units: false

metaR FAOXC164C165x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:5)x
type: Reaction

metaR EX glygn5 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycogen, structure 5 (glycogenin-2[1,4-Glc])
type: Reaction

metaR S6T16g
reactant: MODEL1310110001#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is: SBO:0000176
type: Reaction
modifier: MODEL1310110001#
fast: false

metaR GALASE19ly
kinetic law: MODEL1310110001#
name: beta-galactosidase, lysosomal
reversible: false
is: SBO:0000176
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000269
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
product: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR FACOAL203
reactant: MODEL1310110001#
name: fatty-acid--CoA ligase
kinetic law: MODEL1310110001#
reversible: true
is described by: ECO:0000000
modifier: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_ecdeca2e_6064_4f12_8860_b7cd306997e5
boundary condition: true
name: HGD
constant: false
type: Species
initial amount: NaN
is: SBO:0000252
is: Q93099
is encoded by: hsa:3081
initial concentration: NaN
has only substance units: false

metaR CHOLtu
notes: GENE_ASSOCIATION: (6582.1) or (6584.1) or (6582.2) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev
is described by: ECO:0000269
is: SBO:0000185
type: Reaction
product: MODEL1310110001#
reversible: true
modifier: MODEL1310110001#
reactant: MODEL1310110001#
name: Choline uniport
kinetic law: MODEL1310110001#
fast: false

metaR FAOXC226
is version of: http://identifiers.org/ec-code/1.3.8.1
modifier: MODEL1310110001#
fast: false
product: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TV Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
is described by: ECO:0000000
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110001#_a125a7ce_a399_4593_9a1c_6fa808ffbcff
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:10587
is: SBO:0000252
type: Species
initial concentration: NaN
has only substance units: false
name: TXNRD2

metaR biomass reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: false
is described by: ECO:0000134
name: biomass_reaction
fast: false
is: SBO:0000185
reactant: MODEL1310110001#
type: Reaction

metaR PSFLIPm
reversible: false
is described by: ECO:0000269
product: MODEL1310110001#
is: SBO:0000185
name: phosphatidylserine flippase
notes: GENE_ASSOCIATION: (10396.1) or (57194.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10198212,PMID:10856717,PMID:11353404 NOTES:See PMID: 10856717 - flippase activity no detailed data on which compartment ATP hydrolysis occurs, so for the time being assumed to be cytosolic NJ
kinetic law: MODEL1310110001#
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/3.6.3.1
modifier: MODEL1310110001#
reactant: MODEL1310110001#

metaR FAOXC225C226m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:5-->C22:6)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_cd68b8b7_1975_41f0_ad10_fc841df07a4f
is: P43155
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: CRAT
is encoded by: hsa:1384
has only substance units: false
initial concentration: NaN
constant: false
type: Species

metaM ksi deg29 l
is: CHEBI:12936
initial amount: NaN
type: Species
name: keratan sulfate I, degradation product 29
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB00143
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C96H157N6O80S3 CHARGE: -3

http://identifiers.org/biomodels.db/MODEL1310110001#_f8d58821_072b_48de_9685_3050eb8a9d90
is: P17568
name: NDUFB7
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4713
constant: false
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaR EX C02528 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chenodeoxycholate exchange
type: Reaction

metaM HC02216 e
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: SBO:0000247
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
name: prostaglandin-f2beta
constant: false
type: Species
is: CHEBI:28922

metaR It
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: Iodide uniport
fast: false
is described by: ECO:0000269
modifier: MODEL1310110001#
reactant: MODEL1310110001#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: (160728.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:1217270 NOTES:NCD
is: SBO:0000185

metaM biocyt m
name: Biocytin
is: SBO:0000247
notes: FORMULA: C16H28N4O4S CHARGE: 0 INCHI: InChI=1/C16H28N4O4S/c17-10(15(22)23)5-3-4-8-18-13(21)7-2-1-6-12-14-11(9-25-12)19-16(24)20-14/h10-12,14H,1-9,17H2,(H,18,21)(H,22,23)(H2,19,20,24)/t10-,11-,12-,14-/m0/s1 EHMN_ABBREVIATION: C05552
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7886
type: Species
constant: false
boundary condition: false
is: C05552
has only substance units: false
is: HMDB03134
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_aa14e3fc_79fd_4958_bb37_7433344d7d09
has only substance units: false
constant: false
initial concentration: NaN
type: Species
initial amount: NaN
name: PDE9A
is encoded by: hsa:5152
is: SBO:0000252
boundary condition: true

metaR RE1530C
product: MODEL1310110001#
reversible: true
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000176
name: RE1530
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.1.21 Confidence Level: 0 AUTHORS: PMID:11812127 NOTES:
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110001#

metaR CSNATr
is described by: ECO:0000000
reversible: true
fast: false
type: Reaction
product: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
name: carnitine O-acetyltransferase
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:11257506,PMID:7829107 NOTES:IF

metaR FACOAL204
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
fast: false
notes: GENE_ASSOCIATION: (22305.1) or (2181.2) or (2181.1) or (2180.1) or (22305.2) or (2182.1) or (2182.2) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA NJ. Merged GPR from FACOAL204 and FACOAL204i - (May 2011) IT
product: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#

metaM c226coa m
initial amount: NaN
name: cervonyl coenzyme A
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
initial concentration: 1.0
boundary condition: false
is: C16169
type: Species
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/47205479
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_03a780c6_755d_4339_a105_9f21ef66b35d
has only substance units: false
type: Species
name: NDUFA11
boundary condition: true
initial concentration: NaN
is: C9JT23
initial amount: NaN
constant: false
is encoded by: hsa:126328
is: SBO:0000252

metaM ksi deg14 l
has only substance units: false
name: keratan sulfate I, degradation product 14
type: Species
boundary condition: false
is: CHEBI:12936
is: HMDB00143
notes: FORMULA: C166H267N11O145S8 CHARGE: -8
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
constant: false

metaR r0575
reversible: true
product: MODEL1310110001#
is described by: ECO:0000000
name: Presqualene diphosphate:farnesyl-diphosphate farnesyltransferase Biosynthesis of steroids EC:2.5.1.21
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (AA021081.1) or (AI440329.1) or (R06874.1) or (83549.1) or (7371.1) or (54963.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 0 AUTHORS: PMID:10449533,PMID:1527001,PMID:7864626,PMID:8509416 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.48
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
is: SBO:0000176

metaR LINKDEG2ly
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
reactant: MODEL1310110001#
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reversible: false
name: degradation of proteoglycan linkage region, lysosomal
is described by: ECO:0000000

metaR FACOAL206
is described by: ECO:0000269
kinetic law: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
modifier: MODEL1310110001#
name: fatty-acid--CoA ligase
reversible: true
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/6.2.1.3
is: SBO:0000176

metaM 3hbcoa R m
is: SBO:0000247
has only substance units: false
is: CHEBI:57315
name: (R)-3-hydroxybutanoyl-CoA(4-)
initial amount: NaN
boundary condition: false
type: Species
constant: false
is: HMDB01166
initial concentration: 1.0
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14-,18-,19-,20+,24-/m1/s1

metaM cdp e
boundary condition: false
initial amount: NaN
name: CDP(3-)
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58069
constant: false
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O11P2/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
is: HMDB01546

metaR GUAt
name: Guanine transport
modifier: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:JLR
is described by: ECO:0000269
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_7f1ee207_a700_4246_83ae_7edd7282d61f
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:8854
is: O94788
name: ALDH1A2

http://identifiers.org/biomodels.db/MODEL1310110001#_05377972_416c_4feb_9c34_fa8745f797ba
constant: false
initial concentration: NaN
is encoded by: hsa:594
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
is: P21953
name: BCKDHB
boundary condition: true

metaR EX xylt LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for xylitol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_efbcba64_42a1_4d60_80ef_f1c5880d2ada
initial amount: NaN
name: SLC6A2
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:6530
has only substance units: false
constant: false
is: Q96KH8

metaM c4crn c
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C11H21NO4 CHARGE: 0
type: Species
name: butyryl carnitine
is: HMDB02013
is: C02862
has only substance units: false
is: http://identifiers.org/pubchem.compound/213144
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_ce5fd3a8_a045_4897_bc99_dc04a1d1d73a
type: Species
name: PIGK
initial concentration: NaN
has only substance units: false
is: Q92643
is encoded by: hsa:10026
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_47848d6e_4e89_41de_8d50_c269a6035c1b
boundary condition: true
is encoded by: hsa:7166
initial amount: NaN
name: TPH1
type: Species
initial concentration: NaN
constant: false
has only substance units: false
is: SBO:0000252
is: P17752

metaM ksi l
initial concentration: 1.0
is: SBO:0000247
constant: false
is: CHEBI:57455
is: HMDB01354
name: keratan sulfate I
has only substance units: false
is: C00445
boundary condition: false
type: Species
initial amount: NaN
notes: FORMULA: C247H393N17O213S12X CHARGE: -13

http://identifiers.org/biomodels.db/MODEL1310110001#_f5ce5df6_8db0_45d6_83f7_7584cb0db686
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6579
is: SBO:0000252
has only substance units: false
name: SLCO1A2
initial amount: NaN
type: Species
is: P46721
constant: false

metaR FACOAL205
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
name: fatty-acid--CoA ligase
modifier: MODEL1310110001#
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3

metaM prostgi2 r
constant: false
is: HMDB01335
has only substance units: false
name: prostaglandin I2(1-)
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: CHEBI:57403
type: Species
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24)/p-1/b11-10+,15-8-/t14-,16+,17+,18+,19-/m0/s1 EHMN_ABBREVIATION: C01312

metaM 10fthf c
initial amount: NaN
is: HMDB00972
boundary condition: false
is: CHEBI:57454
initial concentration: 1.0
name: 10-Formyltetrahydrofolate
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
type: Species
has only substance units: false
is: SBO:0000247
constant: false
is: C00234

metaM hexde7coa x
initial amount: NaN
is: HMDB02288
initial concentration: 1.0
constant: false
notes: FORMULA: C37H60N7O17P3S CHARGE: -4
has only substance units: false
is: SBO:0000247
name: 7-hexadecenoylcoa
type: Species
boundary condition: false

metaM HC02216 c
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
boundary condition: false
has only substance units: false
type: Species
notes: FORMULA: C20H33O5 CHARGE: -1 INCHI: InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18+,19+/m0/s1
constant: false
is: CHEBI:28922
name: prostaglandin-f2beta

metaR EX inost LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: myo-Inositol exchange
type: Reaction

metaM ksi pre17 g
is: CHEBI:28067
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
boundary condition: false
is: SBO:0000247
name: keratan sulfate I biosynthesis, precursor 17
notes: FORMULA: C157H252N11O127S5X CHARGE: -6

metaR r2328
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110001#

metaM ppbng c
boundary condition: false
initial amount: NaN
name: Porphobilinogen
has only substance units: false
is: CHEBI:58126
type: Species
constant: false
initial concentration: 1.0
is: HMDB00245
is: C00931
notes: FORMULA: C10H13N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00588 EHMN_ABBREVIATION: C00931
is: SBO:0000247

metaR OCTAt
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:JLR
name: Octanoate transport via diffusion
fast: false
reversible: true
product: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
reactant: MODEL1310110001#

metaM utp m
type: Species
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
boundary condition: false
is: CHEBI:46398
name: UTP(4-)
is: HMDB00285
initial concentration: 1.0

metaR SPC HSt
reversible: true
type: Reaction
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
is: SBO:0000185
name: sphingosylphosphorylcholine transport (diffusion)
is described by: ECO:0000000
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069827 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_29924ef5_785e_4041_81f6_b3a40e6dc39a
is encoded by: hsa:766
boundary condition: true
type: Species
is: P43166
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: CA7
constant: false
initial amount: NaN

metaR NDPK2m
is: SBO:0000176
is described by: ECO:0000254
reversible: true
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
is version of: http://identifiers.org/ec-code/2.7.4.6
modifier: MODEL1310110001#
name: nucleoside-diphosphate kinase (ATP:UDP), mitochondrial
type: Reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#

metaM nad c
constant: false
type: Species
is: C00003
is: http://identifiers.org/pubchem.compound/3305
is: HMDB00902
has only substance units: false
is: CHEBI:57540
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: Nicotinamide adenine dinucleotide
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_c92a165d_5d9e_44a6_89bb_22c04a8a62ed
constant: false
is encoded by: hsa:1339
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
is: Q02221
name: COX6A2
boundary condition: true
initial concentration: NaN

metaR r1544
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110001#
is: SBO:0000185
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_e3d46c89_4672_409e_8e91_851ad785035f
type: Species
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:5295
name: PIK3R1
is: E7EX19
initial concentration: NaN
is: SBO:0000252

metaR OMHPALTD
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of w-hydroxypalmitic acid by diffusion
type: Reaction

metaM c4crn e
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02013
is: C02862
constant: false
is: http://identifiers.org/pubchem.compound/213144
type: Species
initial amount: NaN
boundary condition: false
notes: FORMULA: C11H21NO4 CHARGE: 0
name: butyryl carnitine

metaM crn x
boundary condition: false
constant: false
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial amount: NaN
is: C00318
name: L-Carnitine
is: CHEBI:16347
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00062
has only substance units: false

metaR r1690
reversible: false
reactant: MODEL1310110001#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110001#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_e475d058_1707_4e7e_ae5e_3e45f434523d
initial concentration: NaN
has only substance units: false
name: SYNJ1
constant: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:8867
type: Species
boundary condition: true
is: O43426

metaR SUBEACTD
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of suberic acid into cytosol (diffusion)
type: Reaction

metaR DHFtm
product: MODEL1310110001#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110001#
is: SBO:0000185
kinetic law: MODEL1310110001#
name: dihydrofolate reversible mitochondrial transport
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
type: Reaction

metaR r2329
product: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
reversible: true
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
is described by: ECO:0000000
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false

metaM 3dodtricoa x
boundary condition: false
is: SBO:0000247
type: Species
is: C05279
initial amount: NaN
name: 3,6,9-dodecatrienoylcoa
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
has only substance units: false
is: HMDB11123

metaR PHYCBOXL
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.28
reactant: MODEL1310110001#
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Phenylalanine metabolism EC Number: 4.1.1.28 Confidence Level: 1 AUTHORS: NOTES:SAB
is described by: ECO:0000212
fast: false
name: L-Phenylalanine carboxy-lyase
modifier: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#

metaR NDPK2n
reversible: true
kinetic law: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
fast: false
reactant: MODEL1310110001#
name: nucleoside-diphosphate kinase (ATP:UDP), nuclear
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
is described by: ECO:0000269

metaM utp n
is: CHEBI:46398
name: UTP(4-)
has only substance units: false
is: HMDB00285
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C9H11N2O15P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/p-4/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00077 EHMN_ABBREVIATION: C00075
type: Species
boundary condition: false

metaR EX cys L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-cysteine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_00ca4ede_a933_436d_82e3_7e7255f61d63
is: SBO:0000252
type: Species
boundary condition: true
name: SLC25A26
initial concentration: NaN
is: F8WAB8
has only substance units: false
initial amount: NaN
is encoded by: hsa:115286
constant: false

metaR PIPLC
is version of: http://identifiers.org/ec-code/3.1.4.11
is: SBO:0000176
notes: GENE_ASSOCIATION: (23236.2) or (5336.1) or (23007.1) or (113026.1) or (89869.1) or (84812.1) or (9651.1) or (5335.1) or (51196.1) or (257068.1) or (5332.2) or (5331.1) or (5335.2) or (5334.1) or (5332.1) or (5330.1) or (23236.1) or (5333.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.4.3 Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
modifier: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
name: phosphatidylinositol phospholipase C
reactant: MODEL1310110001#
fast: false
reversible: false

metaR HISTAtu
product: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6581.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
type: Reaction
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
name: Histamine uniport
fast: false
reversible: true
modifier: MODEL1310110001#
is described by: ECO:0000269

metaM HC00900 c
initial amount: NaN
boundary condition: false
type: Species
name: Methylmalonate
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:30860
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170

metaR r0579
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (84890.1) or (AV713053.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:
is described by: ECO:0000000
type: Reaction
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
reversible: true
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.13.11.19
product: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_fd62f0be_d83c_4098_bdf3_1009e364e2d9
is: SBO:0000252
type: Species
has only substance units: false
is: E9PCI1
name: ACP2
is encoded by: hsa:53
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN

metaM acnacngalgbside hs g
initial amount: NaN
is: CHEBI:3338
is: SBO:0000247
boundary condition: false
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
has only substance units: false
name: disialyl galactosylgloboside
constant: false
type: Species
initial concentration: 1.0
is: HMDB00223
is: C00036

metaM gua c
name: Guanine
type: Species
is: C00242
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:16235
notes: FORMULA: C5H5N5O CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial concentration: 1.0
is: HMDB00132
initial amount: NaN

metaR r1547
type: Reaction
is described by: ECO:0000000
reversible: true
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000185

metaM leuktrA4 c
is: CHEBI:57463
initial amount: NaN
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
is: HMDB01337
constant: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
name: leukotriene A4(1-)

http://identifiers.org/biomodels.db/MODEL1310110001#_cf1f9263_1fcb_48b4_939d_f9a860bbc5f2
initial concentration: NaN
constant: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:518
name: ATP5G3
type: Species
has only substance units: false

metaR COQ3m
name: methyltransferase COQ3
type: Reaction
reversible: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.1.1.114
notes: GENE_ASSOCIATION: (51805.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10777520,PMID:11051212,PMID:1965190,PMID:7380842 NOTES:_2.1.1.114 IT
is described by: ECO:0000269
fast: false
product: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_0a7f8d38_8a8a_4ad1_ae63_b520ee687b34
is: SBO:0000252
name: SLC10A2
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
constant: false
has only substance units: false
is encoded by: hsa:6555
is: Q12908

metaM c226coa x
boundary condition: false
is: C16169
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
is: http://identifiers.org/pubchem.compound/47205479
initial amount: NaN
notes: FORMULA: C43H62N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4,7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b6-5-,9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37-,38?,42-/m1/s1
name: cervonyl coenzyme A

http://identifiers.org/biomodels.db/MODEL1310110001#_c054a2e4_5bf0_4daa_a67e_27e673bdd455
is: SBO:0000252
constant: false
is: D3DWC4
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:259230
boundary condition: true
name: SGMS1

metaR RE3005M
modifier: MODEL1310110001#
name: RE3005
product: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (3295.1) or (1962.1) or (3033.1) or (3028.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.1.1.35 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.107
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
kinetic law: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
reversible: true

metaR r0578
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is: SBO:0000176
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/4.1.2.27
reversible: true
notes: GENE_ASSOCIATION: (8879.1) SUBSYSTEM: CoA synthesis EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:13163064,PMID:15105273,PMID:15659606 NOTES:

metaR FAOXC12C12OHm
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C12-->OHC12)m
type: Reaction

metaR r1546
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000185
reversible: true

metaM nadh c
is: C00004
name: Nicotinamide adenine dinucleotide - reduced
is: SBO:0000247
is: CHEBI:57945
has only substance units: false
initial amount: NaN
boundary condition: false
constant: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3306
type: Species
is: HMDB01487

http://identifiers.org/biomodels.db/MODEL1310110001#_54047cf9_74e9_424b_80f9_ec22d3029720
constant: false
type: Species
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: O75251
has only substance units: false
is encoded by: hsa:374291
name: NDUFS7

metaM ptrc c
is: SBO:0000247
is: CHEBI:326268
type: Species
initial concentration: 1.0
name: Putrescine
constant: false
is: C00134
has only substance units: false
is: HMDB01414
boundary condition: false
initial amount: NaN
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134

metaM crn m
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
constant: false
is: SBO:0000247
is: HMDB00062
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: L-Carnitine
initial amount: NaN
is: CHEBI:16347
type: Species
is: C00318

metaR CYTK12n
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110001#
is described by: ECO:0000269
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
name: cytidylate kinase (dCMP,dCTP),nuclear
is: SBO:0000176
type: Reaction
reactant: MODEL1310110001#
reversible: true
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_ec5bfd60_e0a3_4ce3_b937_9e17e366cb3c
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
is: F6VPY9
is encoded by: hsa:6546
name: SLC8A1

metaR RE0452M
reactant: MODEL1310110001#
type: Reaction
name: RE0452
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.9 Confidence Level: 0 AUTHORS: PMID:8024690 NOTES:
fast: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_81e56193_a18c_4a93_955e_61b6f5b6f1fd
is encoded by: hsa:2098
initial concentration: NaN
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
constant: false
is: P10768
name: ESD
is: SBO:0000252

metaM sebacid c
is: C08277
boundary condition: false
type: Species
notes: FORMULA: C10H16O4 CHARGE: -2
initial amount: NaN
is: HMDB00792
constant: false
is: SBO:0000247
name: sebacicacid
has only substance units: false
initial concentration: 1.0

metaR MI145PK
is described by: ECO:0000269
type: Reaction
name: inositol-1,4,5-trisphosphate 3-kinase
is: SBO:0000176
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.1.127
modifier: MODEL1310110001#
reversible: false
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (3706.1) or (80271.1) or (3707.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.127 Confidence Level: 4 AUTHORS: PMID:11085927,PMID:1654894,PMID:2906139 NOTES:NCD

metaM 4fumacac c
constant: false
is: HMDB01268
has only substance units: false
name: 4-fumarylacetoacetate(2-)
initial amount: NaN
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
is: CHEBI:18034
notes: FORMULA: C8H6O6 CHARGE: -2 INCHI: InChI=1S/C8H8O6/c9-5(1-2-7(11)12)3-6(10)4-8(13)14/h1-2H,3-4H2,(H,11,12)(H,13,14)/p-2/b2-1+ HEPATONET_1.0_ABBREVIATION: HC00648 EHMN_ABBREVIATION: C01061

metaM glyald m
name: D-glyceraldehyde
boundary condition: false
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h1,3,5-6H,2H2/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
initial amount: NaN
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: CHEBI:17378
type: Species
is: HMDB01051

metaM leuktrA4 e
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
initial amount: NaN
name: leukotriene A4(1-)
type: Species
is: SBO:0000247
boundary condition: false
is: HMDB01337
initial concentration: 1.0
constant: false
has only substance units: false
is: CHEBI:57463

metaR PEPCKm
is: SBO:0000176
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110001#
name: Phosphoenolpyruvate carboxykinase (GTP)
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (5106.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 4.1.1.32 Confidence Level: 0 AUTHORS: PMID:8645161 NOTES:
modifier: MODEL1310110001#
reversible: false
is version of: http://identifiers.org/ec-code/4.1.1.32

metaM f1a g
initial amount: NaN
type: Species
notes: FORMULA: C22H37N2O15X CHARGE: 0
name: F1alpha
boundary condition: false
has only substance units: false
is: HMDB02917
is: SBO:0000247
constant: false
initial concentration: 1.0
is: CHEBI:17151

metaM ksi pre21 g
is: SBO:0000247
type: Species
is: C00130
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:58053
name: keratan sulfate I biosynthesis, precursor 21
is: HMDB00175
constant: false
notes: FORMULA: C177H284N12O145S6X CHARGE: -7

metaM 1p3h5c c
is: SBO:0000247
constant: false
is: HMDB01369
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
has only substance units: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
boundary condition: false
is: CHEBI:6151
initial amount: NaN
initial concentration: 1.0
type: Species

metaR r1549
is described by: ECO:0000000
kinetic law: MODEL1310110001#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reactant: MODEL1310110001#
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_90db07cc_687f_4edb_99fd_c50fd511d567
is: SBO:0000252
is encoded by: hsa:5149
has only substance units: false
name: PDE6H
boundary condition: true
initial amount: NaN
type: Species
is: Q13956
initial concentration: NaN
constant: false

metaM ach n
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB00895
constant: false
is: CHEBI:15355
name: acetylcholine
has only substance units: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
initial amount: NaN

metaR HAS2
fast: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.212
is: SBO:0000185
name: hyaluronan synthase
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (3038.2) or (3036.1) or (3038.1) or (3037.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 2.4.1.212 Confidence Level: 4 AUTHORS: PMID:12512858,PMID:8651928,PMID:8798477,PMID:8798544,PMID:9083017 NOTES:NCD
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_7d81ec14_2f3f_46d1_a512_cd74fe25dd97
boundary condition: true
is encoded by: hsa:210
is: Q6ZMU0
is: SBO:0000252
initial concentration: NaN
type: Species
name: ALAD
constant: false
initial amount: NaN
has only substance units: false

metaR EX hdca LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Hexadecanoate (n-C16:0) exchange
type: Reaction

metaR r0355
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
fast: false
kinetic law: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (AA278423.1) or (48.1) or (50.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
reactant: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.3

metaR r1548
product: MODEL1310110001#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_ba698a0d_53e1_49c6_a1e7_fbcf1a5e9780
type: Species
constant: false
is encoded by: hsa:2222
boundary condition: true
initial concentration: NaN
name: FDFT1
is: SBO:0000252
is: P37268
has only substance units: false
initial amount: NaN

metaM ptrc e
notes: FORMULA: C4H14N2 CHARGE: 2 HEPATONET_1.0_ABBREVIATION: HC00132 EHMN_ABBREVIATION: C00134
name: Putrescine
is: SBO:0000247
has only substance units: false
boundary condition: false
is: CHEBI:326268
initial concentration: 1.0
is: C00134
type: Species
is: HMDB01414
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_db9f35b6_bebc_40d9_904d_ebd5facf17c4
constant: false
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:514
has only substance units: false
initial amount: NaN
name: ATP5E
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_6c014d73_4273_455b_8023_f48edc5104be
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
is encoded by: hsa:27068
name: PPA2
boundary condition: true
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_24134934_57de_4af1_a0c1_c2b070912f83
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: SBO:0000252
name: PDE5A
constant: false
boundary condition: true
is encoded by: hsa:8654
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_32f5b817_96f0_4de6_83f1_1923f3bc6b48
is encoded by: hsa:389015
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
name: SLC9A4
is: Q6AI14
constant: false
initial concentration: NaN
is: SBO:0000252

metaR r0354
reversible: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110001#
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110001#
type: Reaction
fast: false
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (AA788780.1) or (AA977580.1) or (2180.1) or (2181.1) or (2182.1) or (51703.1) or (23305.1) or (AI694761.1) or (AI915649.1) or (AL525798.1) or (AV727634.1) or (728637.1) or (LOC728997.1) or (11001.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:

metaR EX ppi LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ppi
type: Reaction

metaM retinal 11 cis c
boundary condition: false
constant: false
has only substance units: false
type: Species
is: CHEBI:16066
is: SBO:0000247
is: HMDB02152
initial amount: NaN
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
name: 11-cis-retinal
initial concentration: 1.0

metaM ile L m
type: Species
has only substance units: false
name: L-isoleucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
is: HMDB00172
is: CHEBI:17191
is: SBO:0000247
constant: false
initial concentration: 1.0
initial amount: NaN
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_b114d9ce_a4e0_44d1_8713_20a86d3f1482
is encoded by: hsa:AL525798
initial amount: NaN
constant: false
initial concentration: NaN
name: _AL525798_1_c
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species

metaM malcoa r
is: CHEBI:57384
boundary condition: false
has only substance units: false
initial amount: NaN
is: HMDB01175
type: Species
notes: FORMULA: C24H33N7O19P3S CHARGE: -5 INCHI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/p-5/t12-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00086 EHMN_ABBREVIATION: C00083
name: malonyl-CoA(4-)
is: SBO:0000247
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_3088b5f9_4aa9_4702_b757_d8e10ad6b7a2
name: SLC19A3
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
is: Q9BZV2
constant: false
is encoded by: hsa:80704
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_c8d26af4_52ef_4495_9319_93126b441739
type: Species
initial concentration: NaN
name: PIK3C2G
has only substance units: false
is: O75747
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:5288

http://identifiers.org/biomodels.db/MODEL1310110001#_2478fce4_a1fa_4df7_8aeb_cfea2fbb8548
type: Species
has only substance units: false
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: ACO1
is encoded by: hsa:48
boundary condition: true
is: P21399

metaM acnacngalgbside hs c
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
boundary condition: false
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: C00036
name: disialyl galactosylgloboside
is: HMDB00223
is: SBO:0000247
is: CHEBI:3338

metaM retinol c
is: CHEBI:50211
initial amount: NaN
name: retinol
constant: false
boundary condition: false
has only substance units: false
is: HMDB00305
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3
is: SBO:0000247
initial concentration: 1.0
type: Species

metaR EX adrn LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: adrenic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_c899b8ba_2c13_4132_909b_5c38ccb2d797
name: CEPT1
is: B3KN25
has only substance units: false
is: SBO:0000252
is encoded by: hsa:10390
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
boundary condition: true

metaR DNDPt27m
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
reversible: false
modifier: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185
name: dCDP transport via dTDP antiport
is described by: ECO:0000269
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_c69bd9d2_685b_4f50_ad98_8dabee1443a5
constant: false
type: Species
is: P04181
initial concentration: NaN
is encoded by: hsa:4942
boundary condition: true
initial amount: NaN
name: OAT
is: SBO:0000252
has only substance units: false

metaM CE5118 m
has only substance units: false
is: CHEBI:57923
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C35H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,12-15,22-24,28-30,34,45-46H,4-7,10-11,16-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,13-12-,15-14+/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE5118
is: SBO:0000247
type: Species
boundary condition: false
name: trans-2-cis,cis-4,8-tetradecatrienoyl-CoA

metaM crn r
constant: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C7H15NO3 CHARGE: 0 INCHI: InChI=1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
is: SBO:0000247
is: CHEBI:16347
name: (R)-carnitine
boundary condition: false
type: Species
is: HMDB00062

metaM decdicrn e
boundary condition: false
is: SBO:0000247
is: HMDB13325
type: Species
name: decadienoyl carnitine
constant: false
notes: FORMULA: C17H29NO4 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaR 3MOPt2im
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is: SBO:0000185
reactant: MODEL1310110001#
fast: false
is described by: ECO:0000000
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport
reversible: false
type: Reaction
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_a11cd0cc_be35_441f_9fc6_2c5db980d678
name: TYMS
boundary condition: true
is encoded by: hsa:7298
initial concentration: NaN
is: P04818
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species

metaM dolp L r
name: dolichyl phosphate(2-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C1080H1758O40P10 CHARGE: -20 INCHI: InChI=1S/C25H45O4P/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-29-30(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H2,26,27,28)/p-2/b22-13+,23-15+,24-17- EHMN_ABBREVIATION: C00110
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
boundary condition: false
is: CHEBI:57683

http://identifiers.org/biomodels.db/MODEL1310110001#_e686dcea_bffd_4d6d_9a1b_2c3571f7ce97
initial concentration: NaN
is: B3KRZ3
name: IMPDH1
type: Species
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:3614
boundary condition: true
initial amount: NaN

metaM HC01603 c
is: C00234
is: SBO:0000247
type: Species
name: 10-Formyltetrahydrofolate
has only substance units: false
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
is: CHEBI:57454
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_41d490e6_8521_4c1f_873c_840b61d76ddd
is: Q6UVY6
type: Species
constant: false
initial amount: NaN
is encoded by: hsa:26002
is: SBO:0000252
name: MOXD1
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM his L c
name: L-histidine
is: CHEBI:15971
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial concentration: 1.0
is: HMDB00177
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_9c151a79_7ef2_4144_8945_40a379c9b960
type: Species
is encoded by: hsa:221823
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
has only substance units: false
name: PRPS1L1
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_0644a795_16c9_41c4_b08d_f559071b454d
initial concentration: NaN
is encoded by: hsa:956
constant: false
is: O75355
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
name: ENTPD3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_908cd333_a4f0_4513_94c4_bb7e1c4cfc33
is: SBO:0000252
boundary condition: true
type: Species
name: PLCXD2
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:257068
is: Q0VAA5
initial amount: NaN

metaM 10fthf m
is: CHEBI:57454
is: SBO:0000247
boundary condition: false
type: Species
constant: false
is: HMDB00972
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 INCHI: InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)23-11(7-22-16)8-27(9-28)12-3-1-10(2-4-12)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,11,13,23H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,22,25,26,32)/p-2/t11-,13+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
name: 10-formyltetrahydrofolate(2-)
has only substance units: false
initial amount: NaN

metaR EX for LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Formate exchange
type: Reaction

metaR O2t
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:tv renamed from O2TP to O2t to avoid confusion with transport reaction from cytosol to peroxisome NCD
fast: false
product: MODEL1310110001#
is described by: ECO:0000000
name: o2 transport (diffusion)
kinetic law: MODEL1310110001#
is: SBO:0000185
type: Reaction
reactant: MODEL1310110001#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_7c667a42_f5ae_42e0_b243_07f609c854fe
is encoded by: hsa:514
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
name: ATP5E
constant: false
type: Species
is: P56381

metaM HC01118 r
type: Species
constant: false
is: CHEBI:57310
has only substance units: false
notes: FORMULA: C30H49O7P2 CHARGE: -3 INCHI: InChI=1S/C30H52O7P2/c1-23(2)13-9-15-25(5)17-11-18-27(7)21-28-29(22-36-39(34,35)37-38(31,32)33)30(28,8)20-12-19-26(6)16-10-14-24(3)4/h13-14,17,19,21,28-29H,9-12,15-16,18,20,22H2,1-8H3,(H,34,35)(H2,31,32,33)/p-3/b25-17+,26-19+,27-21+/t28-,29-,30-/m0/s1 EHMN_ABBREVIATION: C03428
initial concentration: 1.0
initial amount: NaN
name: presqualene diphosphate(3-)
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_0caf9c97_58a6_4e83_8d13_6aae39e20e3d
has only substance units: false
name: VNN3
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:55350
initial amount: NaN

metaR GLCNACASE3ly
reversible: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is: SBO:0000176
name: alpha-N-acetylglucosaminidase, lysosomal
product: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.50
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false

metaR CSNATm
notes: GENE_ASSOCIATION: (1384.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.7 Confidence Level: 4 AUTHORS: PMID:3759988 NOTES:TDV
reactant: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000269
kinetic law: MODEL1310110001#
type: Reaction
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.7
modifier: MODEL1310110001#
reversible: true
name: carnitine O-aceyltransferase, mitochondrial

metaM 2dp6mep m
has only substance units: false
type: Species
name: 2-Decaprenyl-6-methoxyphenol
notes: FORMULA: C57H88O2 CHARGE: 0 INCHI: InChI=1S/C57H88O2/c1-45(2)23-13-24-46(3)25-14-26-47(4)27-15-28-48(5)29-16-30-49(6)31-17-32-50(7)33-18-34-51(8)35-19-36-52(9)37-20-38-53(10)39-21-40-54(11)43-44-55-41-22-42-56(59-12)57(55)58/h22-23,25,27,29,31,33,35,37,39,41-43,58H,13-21,24,26,28,30,32,34,36,38,40,44H2,1-12H3/b46-25+,47-27+,48-29+,49-31+,50-33+,51-35+,52-37+,53-39+,54-43+
boundary condition: false
is: CHEBI:50774
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN

metaR ACOAO7p
name: acyl-CoA oxidase (hexadecanoyl-CoA), peroxisomal
is version of: http://identifiers.org/ec-code/1.3.3.6
fast: false
type: Reaction
reactant: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (51.1) or (51.2) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 4 AUTHORS: PMID:7876265,PMID:8159712 NOTES:NCD
is described by: ECO:0000269
reversible: false
modifier: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_5b798549_7918_4d7f_94de_adc168e8dddc
is encoded by: hsa:9380
is: Q9UBQ7
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
type: Species
name: GRHPR

metaR PDX5PO
fast: false
is version of: http://identifiers.org/ec-code/1.4.3.5
reversible: true
modifier: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (55163.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: 1.4.3.5 Confidence Level: 4 AUTHORS: PMID:15182361,PMID:6380540 NOTES:NCD
is described by: ECO:0000269
product: MODEL1310110001#
is: SBO:0000176
name: pyridoxine 5'-phosphate oxidase
kinetic law: MODEL1310110001#

metaR MI145PP
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.56 Confidence Level: 4 AUTHORS: PMID:10593988,PMID:10764818,PMID:15261714,PMID:2906139,PMID:7721860,PMID:8006039,PMID:8013665,PMID:8530088,PMID:8769125,PMID:9428629,PMID:9824312 NOTES:NCD
reactant: MODEL1310110001#
fast: false
product: MODEL1310110001#
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110001#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.1.3.56
is version of: http://identifiers.org/ec-code/3.1.3.86
is version of: http://identifiers.org/ec-code/3.1.3.36
type: Reaction
name: inositol-1,4,5-trisphosphate 5-phosphatase

metaM n2m2mn l
is: HMDB00742
notes: FORMULA: C42H71N3O31 CHARGE: 0
has only substance units: false
is: SBO:0000247
constant: false
initial amount: NaN
type: Species
name: de-Fuc, reducing GlcNAc removed, de-Sia, de-Gal form of PA6 (w/o peptide linkage)
initial concentration: 1.0
is: CHEBI:17588
boundary condition: false

metaM c4crn m
constant: false
is: SBO:0000247
type: Species
is: HMDB02013
is: C02862
notes: FORMULA: C11H21NO4 CHARGE: 0
has only substance units: false
name: butyryl carnitine
initial amount: NaN
boundary condition: false
is: http://identifiers.org/pubchem.compound/213144
initial concentration: 1.0

metaM gua e
type: Species
notes: FORMULA: C5H5N5O CHARGE: 0 INCHI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11) HEPATONET_1.0_ABBREVIATION: HC00219 EHMN_ABBREVIATION: C00242
initial concentration: 1.0
is: CHEBI:16235
constant: false
is: SBO:0000247
has only substance units: false
is: HMDB00132
initial amount: NaN
name: guanine
boundary condition: false

metaM acnacngalgbside hs e
boundary condition: false
is: HMDB00223
is: SBO:0000247
has only substance units: false
initial amount: NaN
is: CHEBI:3338
notes: FORMULA: C72H121N4O43FULLRCO CHARGE: -2
name: disialyl galactosylgloboside
initial concentration: 1.0
constant: false
type: Species
is: C00036

http://identifiers.org/biomodels.db/MODEL1310110001#_54cbcf1b_ded3_46bb_8140_9040530eb8bc
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:8714
is: O15438
initial concentration: NaN
name: ABCC3
type: Species
constant: false
has only substance units: false

metaR UGALNACtg
fast: false
product: MODEL1310110001#
reactant: MODEL1310110001#
reversible: true
type: Reaction
modifier: MODEL1310110001#
is described by: ECO:0000269
name: UDP-GalNAc Golgi transport via CMP antiport
notes: GENE_ASSOCIATION: (7355.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 4 AUTHORS: PMID:11784306,PMID:8889805,PMID:9010752,PMID:9399569,PMID:9562625 NOTES:NCD
is: SBO:0000185
kinetic law: MODEL1310110001#

metaM decdicrn c
is: SBO:0000247
name: decadienoyl carnitine
is: HMDB13325
type: Species
notes: FORMULA: C17H29NO4 CHARGE: 0
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
boundary condition: false

metaR FAOXC17C15m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C17-->C15)m
type: Reaction

metaR FACOAL191
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty-acid--CoA ligase
is: SBO:0000176
reactant: MODEL1310110001#
type: Reaction
is described by: ECO:0000269
fast: false
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: false
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:11591435 NOTES:current models suggest COAL activity occurs on outer peroxisomal membrane NJ

http://identifiers.org/biomodels.db/MODEL1310110001#_47c4891f_879d_42ca_ac67_a84a8fd2c7b4
is: Q6NSB3
constant: false
name: AMY1A
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:276
initial concentration: NaN
has only substance units: false
type: Species

metaR DM Asn X Ser Thr ly
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: DM Asn-X-Ser/Thr(ly)
type: Reaction

metaM his L e
is: CHEBI:15971
name: L-histidine
type: Species
has only substance units: false
boundary condition: false
is: HMDB00177
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_e151ce62_e107_41bb_824a_1aad9aef4d88
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
is: O95427
name: PIGN
initial amount: NaN
type: Species
is encoded by: hsa:23556
has only substance units: false

metaR G13MT L
kinetic law: MODEL1310110001#
name: Glycolipid 1,3-alpha-D-mannosyltransferase (liver)
fast: false
type: Reaction
is: SBO:0000176
reactant: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.132
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110001#_47d62b4b_162c_42eb_9384_89be8dc066f8
is encoded by: hsa:57171
has only substance units: false
is: SBO:0000252
is: Q86YN1
constant: false
initial concentration: NaN
type: Species
name: DOLPP1
boundary condition: true
initial amount: NaN

metaR CYSGLYexR
modifier: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185
reactant: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
fast: false
name: L-cysteine/glycine reversible exchanger
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (6520.1) and (23428.1) or (6520.1) and (23428.2) or (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:Merged CYSGLYexR and CYSGLYex - (May 2011) IT
reversible: true

metaR EX fmn LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for FMN
type: Reaction

metaR PRGNLONEtm
product: MODEL1310110001#
name: pregnenolone intracellular transport
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
is described by: ECO:0000000
reactant: MODEL1310110001#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_ee98d620_5cd5_4e06_aa7b_efe5e7cf9796
initial amount: NaN
constant: false
is encoded by: hsa:3636
name: INPPL1
boundary condition: true
initial concentration: NaN
type: Species
is: O15357
is: SBO:0000252
has only substance units: false

metaR EX psyl LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for psyllium
type: Reaction

metaR EX prostgi2 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: prostaglandin I2(1-) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_98aac0f9_b9b0_4995_b176_ee1fe04083ef
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
constant: false
boundary condition: true
name: ATP5L
is encoded by: hsa:10632
is: O75964
has only substance units: false
type: Species

metaM CE2839 e
type: Species
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5041
initial concentration: 1.0
constant: false
name: maltodecaose
notes: FORMULA: C60H102O51 CHARGE: 0 INCHI: InChI=1/C60H102O51/c61-1-11-21(71)22(72)33(83)52(94-11)104-43-13(3-63)96-54(35(85)24(43)74)106-45-15(5-65)98-56(37(87)26(45)76)108-47-17(7-67)100-58(39(89)28(47)78)110-49-19(9-69)102-60(41(91)30(49)80)111-50-20(10-70)101-59(40(90)31(50)81)109-48-18(8-68)99-57(38(88)29(48)79)107-46-16(6-66)97-55(36(86)27(46)77)105-44-14(4-64)95-53(34(84)25(44)75)103-42-12(2-62)93-51(92)32(82)23(42)73/h11-92H,1-10H2/t11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21+,22+,23-,24-,25-,26-,27-,28-,29-,30-,31-,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43+,44+,45+,46+,47+,48+,49+,50+,51u,52+,53+,54+,55+,56+,57+,58+,59+,60+/m1/s1 EHMN_ABBREVIATION: CE2839
has only substance units: false
boundary condition: false
is: C01936
initial amount: NaN

metaM ach c
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00895
is: CHEBI:15355
type: Species
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
boundary condition: false
initial concentration: 1.0
has only substance units: false
name: acetylcholine

http://identifiers.org/biomodels.db/MODEL1310110001#_3a122cc9_72b0_4ed1_abfc_d0a717dbd0c0
is: P78542
has only substance units: false
initial amount: NaN
initial concentration: NaN
type: Species
boundary condition: true
constant: false
name: HK1
is encoded by: hsa:3098
is: SBO:0000252

metaM met L e
is: SBO:0000247
initial concentration: 1.0
type: Species
boundary condition: false
is: CHEBI:16643
constant: false
is: HMDB00696
name: L-methionine
has only substance units: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial amount: NaN

metaM c6dc c
constant: false
boundary condition: false
name: adipoyl carnitine
type: Species
initial amount: NaN
notes: FORMULA: C13H22NO6 CHARGE: -1
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00705

metaM crn e
initial amount: NaN
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318
initial concentration: 1.0
constant: false
is: CHEBI:16347
is: HMDB00062
boundary condition: false
has only substance units: false
is: SBO:0000247
type: Species
is: C00318
name: L-Carnitine

metaM asn L e
is: CHEBI:17196
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
constant: false
initial concentration: 1.0
boundary condition: false
is: HMDB00168
type: Species
initial amount: NaN
name: L-asparagine
has only substance units: false
is: SBO:0000247

metaM ksi deg5 l
has only substance units: false
initial concentration: 1.0
boundary condition: false
is: HMDB00143
name: keratan sulfate I, degradation product 5
notes: FORMULA: C222H356N15O194S11 CHARGE: -11
constant: false
initial amount: NaN
is: CHEBI:12936
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_1c2e5f4d_2594_46de_943d_8d7d88d5726b
is: SBO:0000252
constant: false
name: GGT7
has only substance units: false
initial concentration: NaN
is encoded by: hsa:2686
is: A0PJJ9
boundary condition: true
type: Species
initial amount: NaN

metaM HC00900 m
constant: false
name: Methylmalonate
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: C4H4O4 CHARGE: -2 INCHI: InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8) EHMN_ABBREVIATION: C02170
is: CHEBI:30860
initial amount: NaN
type: Species
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_e4905ef3_ba37_4548_8e43_b207c40df53b
constant: false
is encoded by: hsa:3425
type: Species
is: SBO:0000252
name: IDUA
initial amount: NaN
boundary condition: true
is: P35475
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_f6cbd151_cf9b_42f5_a124_fa908d7caeaa
constant: false
is: Q9NUQ2
name: AGPAT5
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:55326
has only substance units: false
is: SBO:0000252
type: Species

metaR B3GNT39g
name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3, Golgi apparatus
reversible: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (10331.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
product: MODEL1310110001#
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000

metaM prpp e
is: CHEBI:58017
constant: false
type: Species
boundary condition: false
name: 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
is: HMDB00280
notes: FORMULA: C5H8O14P3 CHARGE: -5 INCHI: InChI=1S/C5H13O14P3/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13)/p-5/t2-,3-,4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM xu5p D c
is: HMDB00868
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
name: D-xylulose 5-phosphate(2-)
notes: FORMULA: C5H9O8P CHARGE: -2 INCHI: InChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/p-2/t4-,5-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00209
constant: false
is: SBO:0000247
is: CHEBI:57737
initial amount: NaN

metaM c4crn x
is: SBO:0000247
is: HMDB02013
constant: false
type: Species
initial amount: NaN
is: C02862
has only substance units: false
name: butyryl carnitine
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C11H21NO4 CHARGE: 0
is: http://identifiers.org/pubchem.compound/213144

metaR EX gln L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-glutamine
type: Reaction

metaR NDP7er
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 2 AUTHORS: PMID:10369669 NOTES:NCD
type: Reaction
reactant: MODEL1310110001#
name: nucleoside-diphosphatase (UDP), endoplasmic reticulum
product: MODEL1310110001#
reversible: false
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110001#
is: SBO:0000176

metaM ps hs c
boundary condition: false
constant: false
initial concentration: 1.0
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
is: CHEBI:18303
type: Species
initial amount: NaN
is: SBO:0000247
name: ps_hs[c]
has only substance units: false

metaR EX ddece1crn
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dodecenoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_7f5ae799_6866_43a8_a48f_a02c10019f05
is: Q546E0
boundary condition: true
is encoded by: hsa:2530
type: Species
initial concentration: NaN
name: FUT8
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_9a6fa5dd_bf24_4c34_9916_96fab1b512d2
initial amount: NaN
is: O00154
has only substance units: false
initial concentration: NaN
type: Species
name: ACOT7
is: SBO:0000252
is encoded by: hsa:11332
constant: false
boundary condition: true

metaR EX crn LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-Carnitine
type: Reaction

metaM dcdp m
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: CHEBI:58593
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB01245
name: dCDP(3-)
type: Species
initial amount: NaN

metaR KSII CORE2t
name: keratan sulfate II (core2) transport, golgi to extracellular
is: SBO:0000185
fast: false
reversible: false
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_80117ef9_070b_4d7e_afc8_e1bb189d9624
is: Q6FH11
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:3162
constant: false
name: HMOX1
type: Species

metaR ADKd
reactant: MODEL1310110001#
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
name: adenylate kinase (d form)
notes: GENE_ASSOCIATION: (26289.2) or (26289.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:Inorganic triphosphate can also act as donor This form was added for Staph based on KEGG evidence (SAB)
type: Reaction
is: SBO:0000176
reversible: true
is described by: ECO:0000269

metaM met L c
type: Species
initial amount: NaN
has only substance units: false
notes: FORMULA: C5H11NO2S CHARGE: 0 INCHI: InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00075
initial concentration: 1.0
constant: false
is: HMDB00696
is: CHEBI:16643
name: L-methionine
is: SBO:0000247
boundary condition: false

metaM CE0693 m
boundary condition: false
is: CHEBI:28387
type: Species
is: HMDB11123
name: 3-oxolaur-6-cis-enoyl-CoA
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C33H50N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H54N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-20,22,26-28,32,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE0693
initial concentration: 1.0

metaM ksi deg32 l
initial concentration: 1.0
is: HMDB00143
type: Species
is: CHEBI:12936
is: SBO:0000247
has only substance units: false
constant: false
name: keratan sulfate I, degradation product 32
initial amount: NaN
boundary condition: false
notes: FORMULA: C82H135N5O67S2 CHARGE: -2

metaM crn c
initial concentration: 1.0
initial amount: NaN
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:16347
is: HMDB00062
name: L-Carnitine
type: Species
is: SBO:0000247
is: C00318
notes: FORMULA: C7H15NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00270 EHMN_ABBREVIATION: C00318

metaR VALt5m
name: Valine reversible mitochondrial transport
kinetic law: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11004451 NOTES:MM
fast: false
type: Reaction
reactant: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
reversible: true

metaR FAS100COA
product: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.3.1.85
kinetic law: MODEL1310110001#
name: fatty acyl-CoA synthase (n-C10:0CoA)
reactant: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
fast: false
reversible: false

metaM g2m8masn r
boundary condition: false
constant: false
notes: FORMULA: C82H137N2O65X CHARGE: 0
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
has only substance units: false
is: C05874
type: Species

metaR S6T9g
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
is described by: ECO:0000000
reversible: false
is: SBO:0000176
type: Reaction
modifier: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_9dc35575_3f69_4f8b_9a2f_6f87526b1cd0
constant: false
initial amount: NaN
type: Species
has only substance units: false
is encoded by: hsa:AI620219
initial concentration: NaN
name: _AI620219_1_c
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_87ad8a62_21cd_4180_aac8_88fa1904d2aa
is encoded by: hsa:3706
initial amount: NaN
is: P23677
type: Species
name: ITPKA
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
boundary condition: true

metaM ach e
initial amount: NaN
name: acetylcholine
type: Species
is: CHEBI:15355
initial concentration: 1.0
constant: false
notes: FORMULA: C7H16NO2 CHARGE: 1 INCHI: InChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1 HEPATONET_1.0_ABBREVIATION: HC00877 EHMN_ABBREVIATION: C01996
is: HMDB00895
is: SBO:0000247
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_eaacb2c8_c326_46be_b43a_e3b0e1017b9f
has only substance units: false
is encoded by: hsa:218
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: ALDH3A1
is: P30838
initial amount: NaN
initial concentration: NaN

metaM dcdp n
has only substance units: false
is: SBO:0000247
constant: false
name: dCDP(3-)
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C9H12N3O10P2 CHARGE: -3 INCHI: InChI=1S/C9H15N3O10P2/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17)/p-3/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00506 EHMN_ABBREVIATION: C00705
is: HMDB01245
is: CHEBI:58593

metaR EX glysar LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for glycylsarcosine
type: Reaction

metaR RDH3a
product: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.300
name: retinol dehydrogenase (11-cis,NADPH)
reversible: true
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (112724.1) or (145226.1) or (51109.1) or (57665.1) or (195814.1) SUBSYSTEM: Vitamin A metabolism EC Number: 1.1.1.105 Confidence Level: 4 AUTHORS: PMID:12226107,PMID:12372410,PMID:1503811,PMID:15258582,PMID:15322982 NOTES:IT
is version of: http://identifiers.org/ec-code/1.1.1.105

metaR AG13T7g
is version of: http://identifiers.org/ec-code/2.4.1.149
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110001#
modifier: MODEL1310110001#
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus

metaR SACCD3m
notes: GENE_ASSOCIATION: (10157.1) SUBSYSTEM: Lysine metabolism EC Number: 1.5.1.8 Confidence Level: 4 AUTHORS: PMID:10775527 NOTES:MM
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.5.1.8
reversible: false
product: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000269
name: saccharopine dehydrogenase (NADP, L-lysine forming), mitochondrial
type: Reaction

metaM ps hs e
boundary condition: false
has only substance units: false
initial concentration: 1.0
name: phosphatidylserine
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC02006
initial amount: NaN
is: CHEBI:18303
type: Species
is: SBO:0000247
constant: false

metaM dece4coa x
boundary condition: false
name: 4-decenoylcoa
initial amount: NaN
is: HMDB02145
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
type: Species
constant: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4

metaM 3octdeccrn c
is: SBO:0000247
notes: FORMULA: C25H49NO5 CHARGE: 0
boundary condition: false
type: Species
name: 3-hydroxyoctadecanoyl carnitine
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB13336
initial amount: NaN

metaR TRPHYDRO2
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.14.16.4
type: Reaction
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (7166.1) or (121278.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.14.16.4 Confidence Level: 4 AUTHORS: PMID:10727395,PMID:12379098 NOTES:SAB unlumped version of TRPHYDRO1
reversible: false
modifier: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
name: L-Tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
product: MODEL1310110001#
is: SBO:0000176

metaM pheacgln e
constant: false
type: Species
boundary condition: false
is: CHEBI:58310
is: HMDB06344
initial amount: NaN
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
has only substance units: false
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
initial concentration: 1.0
is: SBO:0000247

metaM dc2coa x
initial concentration: 1.0
constant: false
has only substance units: false
initial amount: NaN
is: HMDB01168
is: SBO:0000247
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
type: Species
name: trans-Dec-2-enoyl-CoA
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_f9eecf1f_8145_4e7e_bb7b_48c56bfd2cd1
boundary condition: true
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: ALDH1B1
is encoded by: hsa:219
is: P30837

metaM ile L e
constant: false
is: CHEBI:17191
is: SBO:0000247
is: HMDB00172
type: Species
name: L-isoleucine
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial concentration: 1.0
initial amount: NaN
boundary condition: false

metaR EX mal L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of L-malate
type: Reaction

metaR ELAIDt
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
name: fatty acid transport via diffusion
type: Reaction

metaR FAOXC80
product: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.3 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:TDV (9/7/2004) Other enzymes: 1.3.3.6, 4.2.1.74, 4.2.1.17, 1.1.1.35, 1.1.1.211
name: Beta oxidation of med/long chain fatty acid
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.99.3
reversible: false
fast: false
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.8.1
is described by: ECO:0000269

metaM 1p3h5c m
constant: false
initial concentration: 1.0
initial amount: NaN
name: L-1-Pyrroline-3-hydroxy-5-carboxylate
is: HMDB01369
boundary condition: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-3-1-4(5(8)9)6-2-3/h2-4,7H,1H2,(H,8,9)/t3-,4+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01261 EHMN_ABBREVIATION: C04281
has only substance units: false
is: CHEBI:6151
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_94c7d310_8658_4ea0_a957_a05824ec3664
has only substance units: false
is encoded by: hsa:57419
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
is: Q9HC58
boundary condition: true
initial amount: NaN
name: SLC24A3

http://identifiers.org/biomodels.db/MODEL1310110001#_e2af42cd_f18c_4f29_ac2c_c8a54b411519
type: Species
is encoded by: hsa:1337
boundary condition: true
constant: false
initial amount: NaN
is: SBO:0000252
has only substance units: false
is: P12074
initial concentration: NaN
name: COX6A1

http://identifiers.org/biomodels.db/MODEL1310110001#_e02749ae_84c8_4445_9a0a_7449eb943365
is: B7Z6S1
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:2629
boundary condition: true
type: Species
is: SBO:0000252
constant: false
name: GBA
has only substance units: false

metaR r0688
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (219.1) or (217.1) or (224.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:11182138,PMID:8155713,PMID:9538213 NOTES:
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al:NAD+ oxidoreductase Bile acid biosynthesis EC:1.2.1.3
modifier: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.2.1.3

http://identifiers.org/biomodels.db/MODEL1310110001#_bfd3adb4_1ad7_42b0_8d6b_b7352c099d47
initial concentration: NaN
boundary condition: true
is: P83881
has only substance units: false
is: SBO:0000252
constant: false
name: RPL36A
initial amount: NaN
type: Species
is encoded by: hsa:6173

metaR RE1845C
reactant: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: (570.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.65 Confidence Level: 0 AUTHORS: PMID:11980911 NOTES:IT - removed 4 h[c] from compEHMN reaction as they were not necessary
product: MODEL1310110001#
name: RE1845
kinetic law: MODEL1310110001#
fast: false
is described by: ECO:0000000
modifier: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.65
is: SBO:0000176

metaM tchola c
initial amount: NaN
boundary condition: false
constant: false
name: taurocholic acid
is: CHEBI:36257
is: SBO:0000247
is: HMDB00036
initial concentration: 1.0
notes: FORMULA: C26H45NO7S CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01378 EHMN_ABBREVIATION: C05122
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_09f9953c_af5d_4fe9_8fd7_9cd3ed978a37
name: DPM2
is: O94777
initial concentration: NaN
type: Species
constant: false
is encoded by: hsa:8818
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_8eb93837_55eb_4e6c_9a66_a8ee681d08ae
is: SBO:0000252
is: Q5DSZ6
constant: false
name: UGT1A8
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:54576
has only substance units: false
initial amount: NaN

metaR S4TASE5ly
reversible: true
notes: GENE_ASSOCIATION: (411.1) or (411.2) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.12 Confidence Level: 4 AUTHORS: PMID:1968043,PMID:2303452 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.6.12
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
modifier: MODEL1310110001#
name: N-acetylgalactosamine-4-sulfatase, lysosomal
product: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_cf5de979_f9fa_4d04_b71d_f631bf802aa0
is: SBO:0000297
is encoded by: hsa:8818
initial amount: NaN
boundary condition: true
is encoded by: hsa:5277
constant: false
has part: P37287
initial concentration: NaN
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has only substance units: false
type: Species

metaM pheacgln c
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C13H16N2O4 CHARGE: 0 INCHI: InChI=1S/C13H16N2O4/c14-11(16)7-6-10(13(18)19)15-12(17)8-9-4-2-1-3-5-9/h1-5,10H,6-8H2,(H2,14,16)(H,15,17)(H,18,19)/p-1/t10-/m0/s1
constant: false
initial amount: NaN
name: (2S)-4-carbamoyl-2-(2-phenylacetamido)butanoate
is: HMDB06344
type: Species
has only substance units: false
is: CHEBI:58310

metaM 3octdeccrn e
initial concentration: 1.0
is: HMDB13336
name: 3-hydroxyoctadecanoyl carnitine
constant: false
notes: FORMULA: C25H49NO5 CHARGE: 0
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_ac070ca1_ba61_4e37_9341_6abb81e54bbd
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
is: P20020
boundary condition: true
name: ATP2B1
is: SBO:0000252
is encoded by: hsa:490

metaM his L m
initial concentration: 1.0
notes: FORMULA: C6H9N3O2 CHARGE: 0 INCHI: InChI=1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00133
name: L-histidine
is: SBO:0000247
is: HMDB00177
boundary condition: false
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:15971

metaR r0166
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.19 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
fast: false
name: Uridine triphosphate pyrophosphohydrolase Pyrimidine metabolism EC:3.6.1.19
is described by: ECO:0000000
reactant: MODEL1310110001#

metaR r2014
reversible: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110001#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
product: MODEL1310110001#
is described by: ECO:0000000
type: Reaction

metaR r0464
kinetic law: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
name: 4-Aminobutyraldehyde:NAD+ oxidoreductase Urea cycle and metabolism of amino groups EC:1.2.1.3
reactant: MODEL1310110001#
reversible: true
fast: false
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:10467734,PMID:11790142,PMID:4817964,PMID:8155713,PMID:8645224,PMID:8786138 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_68604ee9_ea84_4a7c_bb80_949dc72086ff
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:6487
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
is: Q5T4Y1
name: ST3GAL3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_2dc2a858_528f_45b2_a233_a5412e98a944
name: ATP1B1
is encoded by: hsa:481
boundary condition: true
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: A3KLL5
type: Species
is: SBO:0000252

metaM ile L c
constant: false
has only substance units: false
is: CHEBI:17191
is: HMDB00172
name: L-isoleucine
type: Species
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-3-4(2)5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t4-,5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00334 EHMN_ABBREVIATION: C00407
initial concentration: 1.0
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_8502447e_6e37_4a56_8459_2c73a0f999b1
constant: false
initial amount: NaN
name: PMVK
is: Q6FGV9
boundary condition: true
initial concentration: NaN
is encoded by: hsa:10654
is: SBO:0000252
type: Species
has only substance units: false

metaM maltttr e
initial amount: NaN
is: C02052
has only substance units: false
is: http://identifiers.org/pubchem.compound/5141
initial concentration: 1.0
is: SBO:0000247
name: Maltotetraose
type: Species
constant: false
is: HMDB01296
boundary condition: false
notes: FORMULA: C24H42O21 CHARGE: 0 INCHI: InChI=1/C24H42O21/c25-1-5-9(29)10(30)15(35)22(40-5)44-19-7(3-27)42-24(17(37)12(19)32)45-20-8(4-28)41-23(16(36)13(20)33)43-18-6(2-26)39-21(38)14(34)11(18)31/h5-38H,1-4H2/t5-,6-,7-,8-,9-,10+,11-,12-,13-,14-,15-,16-,17-,18-,19-,20-,21u,22-,23-,24-/m1/s1 EHMN_ABBREVIATION: C02052

metaM glu5p m
notes: FORMULA: C5H8NO7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01092 EHMN_ABBREVIATION: C03287
is: HMDB01228
has only substance units: false
is: CHEBI:58274
initial amount: NaN
name: L-Glutamate 5-phosphate
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247

metaR C14STRr
is version of: http://identifiers.org/ec-code/1.3.1.70
product: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110001#
is described by: ECO:0000134
name: C-14 sterol reductase
fast: false
notes: GENE_ASSOCIATION: (7108.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 4 AUTHORS: PMID:16784888 NOTES:NCD ER version NJ
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_d27fcc2f_f822_466d_b714_7323f636a1fe
is: Q96P26
has only substance units: false
is encoded by: hsa:93034
initial amount: NaN
name: NT5C1B
boundary condition: true
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_289b4c53_0a95_404f_bef9_2c4d9b7394b8
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
is encoded by: hsa:8818
name: DPM2
initial amount: NaN
type: Species
has only substance units: false

metaR RE0691C
fast: false
reactant: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
kinetic law: MODEL1310110001#
name: RE0691
is described by: ECO:0000000
type: Reaction
product: MODEL1310110001#
is: SBO:0000176

metaR DNDPt16m
reversible: false
fast: false
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is: SBO:0000185
name: dUDP transport via dADP antiport
kinetic law: MODEL1310110001#
is described by: ECO:0000269

metaM prpp c
initial amount: NaN
is: CHEBI:58017
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
is: HMDB00280
is: C00119
notes: FORMULA: C5H8O14P3 CHARGE: -5 HEPATONET_1.0_ABBREVIATION: HC00117 EHMN_ABBREVIATION: C00119
boundary condition: false
has only substance units: false
name: 5-Phospho-alpha-D-ribose 1-diphosphate

metaR NCAMUP
product: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
reversible: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12069599,PMID:1463467 NOTES:SAB mechanism copied from nac--not certain
type: Reaction
fast: false
name: Nicotinamide acid uptake

metaM tchola e
boundary condition: false
is: SBO:0000247
is: HMDB00036
name: taurocholic acid
initial concentration: 1.0
notes: FORMULA: C26H45NO7S CHARGE: 0
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaR r0463
fast: false
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 2.3.3.10 Confidence Level: 0 AUTHORS: PMID:11087424,PMID:11108725,PMID:1358203,PMID:7893153 NOTES:
reversible: true
type: Reaction
product: MODEL1310110001#
is: SBO:0000176
name: (S)-3-Hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) Synthesis and degradation of ketone bodies / Valine, leucine and isoleucine degradation / Butanoate metabolism EC:2.3.3.10
is described by: ECO:0000000
reactant: MODEL1310110001#

metaR NDP7ex
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12600208 NOTES:
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.6.1.6
type: Reaction
product: MODEL1310110001#
reversible: false
is: SBO:0000176
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
name: nucleoside-diphosphatase (UDP), extracellular

http://identifiers.org/biomodels.db/MODEL1310110001#_5e60ff1f_ec9f_44d1_bc56_7bdd265294b4
is encoded by: hsa:10327
has only substance units: false
type: Species
is: P14550
constant: false
is: SBO:0000252
initial amount: NaN
name: AKR1A1
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_529139b4_fb40_4a74_8596_d025ded60a9f
type: Species
is encoded by: hsa:3158
is: P54868
initial concentration: NaN
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
initial amount: NaN
name: HMGCS2

metaR SBTD D2
fast: false
type: Reaction
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (6652.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.14 Confidence Level: 0 AUTHORS: PMID:14965227 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.14
product: MODEL1310110001#
reactant: MODEL1310110001#
name: D-sorbitol dehydrogenase (D-fructose producing)

metaR SUCRe
type: Reaction
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (6476.1) or (8972.1) SUBSYSTEM: Galactose metabolism EC Number: 3.2.1.26 Confidence Level: 4 AUTHORS: PMID:1560017,PMID:3143729 NOTES:NCD
fast: false
is: SBO:0000176
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.20
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.10
name: sucrose hydrolyzing enxyme, extracellular

http://identifiers.org/biomodels.db/MODEL1310110001#_e5fc3e1c_b9a6_43c3_9a4d_272afaba6e8a
is: Q9NT06
is encoded by: hsa:54511
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true
is: SBO:0000252
name: HMGCLL1

metaR EX malthp LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltoheptaose exchange
type: Reaction

metaR GGH 10FTHF7GLUe
reversible: false
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
reactant: MODEL1310110001#
type: Reaction
name: Gamma-glutamyl hydrolase (10FTHF7GLU), extracellular
fast: false
is version of: http://identifiers.org/ec-code/3.4.19.9

metaM 3docopencoa m
name: 3,7,10,13,16-docosapentenoylcoa
boundary condition: false
constant: false
is: http://identifiers.org/pubchem.compound/24892790
is: SBO:0000247
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4
has only substance units: false

metaR H7ET2er
kinetic law: MODEL1310110001#
is: SBO:0000176
name: H7 phosphoethanolaminyl transferase, endoplasmic reticulum
is described by: ECO:0000000
fast: false
modifier: MODEL1310110001#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.8.1
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (5281.1) and (54872.1) or (5281.2) and (54872.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15632136 NOTES:NCD
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_e0ece6f2_57c0_443e_b39c_ffc924a5d653
name: _BG035985_1_c
initial concentration: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:BG035985
is: SBO:0000252
initial amount: NaN
constant: false

metaR G13MT U
notes: GENE_ASSOCIATION: (85365.1) or (85365.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.132 Confidence Level: 0 AUTHORS: NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.132
kinetic law: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
fast: false
reactant: MODEL1310110001#
modifier: MODEL1310110001#
name: Glycolipid 1,3-alpha-D-mannosyltransferase (uterus)
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110001#_86807378_a23c_4b31_a673_00873851efcd
boundary condition: true
constant: false
name: B3GALT5
has only substance units: false
is encoded by: hsa:10317
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN

metaM vacccoa c
has only substance units: false
is: http://identifiers.org/pubchem.compound/9543677
initial concentration: 1.0
is: SBO:0000247
is: HMDB06521
initial amount: NaN
type: Species
boundary condition: false
constant: false
name: vaccenyl coenzyme A
notes: FORMULA: C39H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(48)67-23-22-41-29(47)20-21-42-37(51)34(50)39(2,3)25-60-66(57,58)63-65(55,56)59-24-28-33(62-64(52,53)54)32(49)38(61-28)46-27-45-31-35(40)43-26-44-36(31)46/h9-10,26-28,32-34,38,49-50H,4-8,11-25H2,1-3H3,(H,41,47)(H,42,51)(H,55,56)(H,57,58)(H2,40,43,44)(H2,52,53,54)/b10-9+/t28-,32-,33?,34+,38-/m1/s1

metaM xoltetrol c
type: Species
is: CHEBI:17278
has only substance units: false
is: SBO:0000247
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
boundary condition: false
initial amount: NaN
constant: false
is: HMDB01231
initial concentration: 1.0
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol

metaR TXA2te
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tc -> TXA2te to get to EC space NJ
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110001#
reversible: true
name: thromboxane A2 transport

metaR GMPtg
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000269
name: GMP transport (Golgi)
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: 6.3.5.2 Confidence Level: 1 AUTHORS: PMID:7706277 NOTES:
reactant: MODEL1310110001#
product: MODEL1310110001#

metaR NADHtpu
kinetic law: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
name: NADH transporter, peroxisome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
is described by: ECO:0000000
is: SBO:0000185
reversible: false
fast: false
reactant: MODEL1310110001#

metaM msa m
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c4-2-1-3(5)6/h2H,1H2,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00203 EHMN_ABBREVIATION: C00222
boundary condition: false
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
name: 3-oxopropanoate
is: HMDB11111
is: CHEBI:33190
is: SBO:0000247

metaM datp n
constant: false
initial concentration: 1.0
is: SBO:0000247
type: Species
name: dATP
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: C00131
initial amount: NaN
has only substance units: false
boundary condition: false
is: CHEBI:61404
is: HMDB01532

metaR FAOXC204C184m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:4-->C18:4)m
type: Reaction

metaR r0698
reactant: MODEL1310110001#
name: Propanoyl-CoA:acetyl-CoA C-acyltransferase Bile acid biosynthesis EC:2.3.1.16
type: Reaction
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.2.27
fast: false
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (10005.1) SUBSYSTEM: Bile acid synthesis EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:1121274,PMID:12543708,PMID:3746130,PMID:6378901 NOTES:
reversible: true
kinetic law: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_26968edb_52de_4fe0_a241_6a571fa28bac
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: UPP1
is: SBO:0000252
is encoded by: hsa:7378
is: Q16831
has only substance units: false
type: Species
constant: false

metaM cspg a e
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: HMDB00630
constant: false
initial amount: NaN
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
is: CHEBI:16040
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_9b44c21b_784e_4252_b9ca_1a25a1f94cf0
is: SBO:0000252
is: Q86VQ6
initial concentration: NaN
is encoded by: hsa:114112
boundary condition: true
has only substance units: false
initial amount: NaN
name: TXNRD3
type: Species
constant: false

metaR CLPNDt
type: Reaction
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110001#
is described by: ECO:0000000
name: fatty acid transport via diffusion
reactant: MODEL1310110001#

metaM ksii core2 pre5 g
type: Species
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate II biosynthesis, precursor 5
constant: false
is: HMDB00175
is: SBO:0000247
notes: FORMULA: C61H99N5O43X CHARGE: -1
has only substance units: false
boundary condition: false
is: CHEBI:58053
is: C00130

http://identifiers.org/biomodels.db/MODEL1310110001#_431d22dc_4aa9_4d68_b3fa_9eff2865e7b3
boundary condition: true
is: Q9H3H5
is: SBO:0000252
name: DPAGT1
initial amount: NaN
constant: false
is encoded by: hsa:1798
initial concentration: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_dd213699_fee5_4ba7_ba6d_5e081f16eee0
has only substance units: false
initial concentration: NaN
name: SLC23A1
initial amount: NaN
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:9963

metaR EX gua LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Guanine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_013348d9_6691_4ba1_9883_bbe0b562368d
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:54677
constant: false
name: CROT
is: SBO:0000252
is: E7EQF2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_7cd597dc_507a_4cba_8dc8_999cca0b214e
boundary condition: true
initial amount: NaN
is: P47895
is encoded by: hsa:220
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252
name: ALDH1A3
type: Species

metaM dcsptn1coa c
is: http://identifiers.org/pubchem.compound/47205483
is: C16173
has only substance units: false
boundary condition: false
is: SBO:0000247
constant: false
type: Species
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: HMDB06513
initial amount: NaN
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A

metaR EX leuktrE4 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene E4 exchange
type: Reaction

metaM ksi deg24 l
boundary condition: false
is: HMDB00143
constant: false
name: keratan sulfate I, degradation product 24
notes: FORMULA: C118H191N8O101S5 CHARGE: -5
is: CHEBI:12936
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247

metaR MI14PP
notes: GENE_ASSOCIATION: (3628.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.61 Confidence Level: 4 AUTHORS: PMID:2906139,PMID:8390685 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.1.3.57
type: Reaction
is described by: ECO:0000269
product: MODEL1310110001#
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: false
name: inositol-1,4-bisphosphate 1-phosphatase
fast: false
is: SBO:0000176
modifier: MODEL1310110001#

metaM galgbside hs g
type: Species
has only substance units: false
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
name: galactosylgloboside
is: CHEBI:18259
initial concentration: 1.0
notes: FORMULA: C50H89N2O27FULLRCO CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110001#_fc62436e_a298_427b_a986_8747dcd07c0a
boundary condition: true
name: PDE9A
initial concentration: NaN
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5152
type: Species

metaM leuktrA4 r
is: SBO:0000247
initial amount: NaN
is: CHEBI:57463
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C20H29O3 CHARGE: -1 INCHI: InChI=1S/C20H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18-19(23-18)16-14-17-20(21)22/h6-7,9-13,15,18-19H,2-5,8,14,16-17H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,12-11+,15-13+/t18-,19-/m0/s1 EHMN_ABBREVIATION: C00909
is: HMDB01337
type: Species
name: leukotriene A4(1-)
initial concentration: 1.0

metaM dcholcoa r
type: Species
has only substance units: false
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
is: SBO:0000247
is: CHEBI:28701
name: chenodeoxycholoyl coenzyme a
boundary condition: false
is: HMDB06292

http://identifiers.org/biomodels.db/MODEL1310110001#_b462b130_2c0b_43cd_a88a_5e19e4ea1eb5
constant: false
name: RHBG
is encoded by: hsa:57127
type: Species
is: Q9H310
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_a14e8434_42f6_40d3_a68d_1bf643350c6a
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q08499
type: Species
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:5144
name: PDE4D

metaR ALAGLYexR
is: SBO:0000185
name: L-alanine/glycine reversible exchange
fast: false
product: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
is described by: ECO:0000304
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reversible: true

metaR AHEXASE2ly
reactant: MODEL1310110001#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
is described by: ECO:0000000
reversible: false
type: Reaction
kinetic law: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD

metaR ABUTD
reversible: false
kinetic law: MODEL1310110001#
is described by: ECO:0000269
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (223.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 1.2.1.19 Confidence Level: 4 AUTHORS: PMID:8786138 NOTES:JLR
type: Reaction
name: Aminobutyraldehyde dehydrogenase
product: MODEL1310110001#
fast: false

metaM pail5p hs n
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
initial concentration: 1.0
constant: false
is: CHEBI:57795

metaR FAOXC183C163Gm
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:3-->C16:3)gm
type: Reaction

metaM nadh r
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C21H27N7O14P2 CHARGE: -2 INCHI: InChI=1S/C21H29N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25)/p-2/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00014 EHMN_ABBREVIATION: C00004
constant: false
type: Species
name: NADH(2-)
is: CHEBI:57945
is: HMDB01487
has only substance units: false
initial amount: NaN
is: SBO:0000247

metaR r2012
reversible: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110001#
modifier: MODEL1310110001#

metaR EX ocdca LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: echange reaction for octadecanoate (n-C18:0)
type: Reaction

metaR GPIAT
notes: GENE_ASSOCIATION: (284098.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14517336 NOTES:EC 2.3.-.- NCD
product: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#
name: glucosaminylphosphatidyl inositol acetyltransferase
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000176

metaR PItn
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
type: Reaction
fast: false
name: phosphate transport, nuclear
is: SBO:0000185
reactant: MODEL1310110001#

metaR MALSO3tm
product: MODEL1310110001#
is described by: ECO:0000269
name: Malate:sulfite antiport, mitochondrial
reversible: true
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
fast: false
reactant: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM

metaR EX co LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Carbon monoxide exchange
type: Reaction

metaM 2mbcoa m
is: CHEBI:57336
is: HMDB01041
initial amount: NaN
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
notes: FORMULA: C26H40N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O17P3S/c1-5-14(2)25(38)54-9-8-28-16(34)6-7-29-23(37)20(36)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-19(49-51(39,40)41)18(35)24(48-15)33-13-32-17-21(27)30-12-31-22(17)33/h12-15,18-20,24,35-36H,5-11H2,1-4H3,(H,28,34)(H,29,37)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t14?,15-,18-,19-,20+,24-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00632 EHMN_ABBREVIATION: C01033
is: SBO:0000247
name: 2-methylbutanoyl-CoA(4-)
boundary condition: false

metaR 4NPHSFte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9344226 NOTES:unknown mechanism, related cyp P450 metabolism reactions NJ. Biochemical, Rat
is described by: ECO:0000000
fast: false
product: MODEL1310110001#
reversible: true
name: xenobiotic transport
kinetic law: MODEL1310110001#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110001#

metaR FAOXC185C164m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C18:5-->C16:4)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_648b9a6e_9c7a_4685_a1e5_de3606832dd6
is: SBO:0000297
is encoded by: hsa:5291
has part: B4DER4
initial amount: NaN
name: PIK3CB:PIK3R1
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:5295
constant: false
has part: B3KT19
initial concentration: NaN

metaR PETOHMm hs
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.1.1.17
name: phosphatidylethanolamine N-methyltransferase
reversible: false
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (10400.2) or (10400.1) or (10400.3) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.17 Confidence Level: 2 AUTHORS: PMID:9989271 NOTES:for human Catalyzes three sequential methylation of phosphatidylethanolamine (PE) by AdoMet, thus producing phosphatidylcholine (PC). [Swiss-prot] NJ
kinetic law: MODEL1310110001#
is: SBO:0000176
type: Reaction
product: MODEL1310110001#
fast: false

metaM g3m8mpdol U r
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
constant: false
initial concentration: 1.0
is: C05873
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C1905H3140N20O770P20 CHARGE: -20
initial amount: NaN

metaM dcholcoa x
is: CHEBI:28701
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB06292
constant: false
notes: FORMULA: C45H70N7O19P3S CHARGE: -4 INCHI: InChI=1S/C45H74N7O19P3S/c1-24(27-7-8-28-34-29(11-14-45(27,28)5)44(4)13-10-26(53)18-25(44)19-30(34)54)6-9-33(56)75-17-16-47-32(55)12-15-48-41(59)38(58)43(2,3)21-68-74(65,66)71-73(63,64)67-20-31-37(70-72(60,61)62)36(57)42(69-31)52-23-51-35-39(46)49-22-50-40(35)52/h22-31,34,36-38,42,53-54,57-58H,6-21H2,1-5H3,(H,47,55)(H,48,59)(H,63,64)(H,65,66)(H2,46,49,50)(H2,60,61,62)/t24-,25+,26-,27-,28+,29+,30-,31-,34+,36-,37-,38+,42-,44+,45-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01426 EHMN_ABBREVIATION: C05337
type: Species
has only substance units: false
name: chenodeoxycholoyl coenzyme a

metaM retinol cis 11 c
notes: FORMULA: C20H30O CHARGE: 0 INCHI: InChI=1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6-,12-11+,16-8+,17-13+
is: SBO:0000247
initial concentration: 1.0
constant: false
name: 11-cis-retinol
type: Species
boundary condition: false
is: HMDB06216
has only substance units: false
initial amount: NaN
is: CHEBI:16302

metaR ACCOAtn
reversible: true
name: acetyl-CoA transport, nuclear
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
is described by: ECO:0000000
reactant: MODEL1310110001#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_0745fc98_c18d_47ab_b4b3_9e80418f6892
is: P47989
is: SBO:0000252
type: Species
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
name: XDH
is encoded by: hsa:7498

http://identifiers.org/biomodels.db/MODEL1310110001#_5a7b8cb7_8f95_4556_9b9f_e0e273a125ae
is: O95167
constant: false
boundary condition: true
name: NDUFA3
has only substance units: false
initial concentration: NaN
initial amount: NaN
type: Species
is encoded by: hsa:4696
is: SBO:0000252

metaR r0580
modifier: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.99.7
is described by: ECO:0000000
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (AD000092.1) or (2639.1) SUBSYSTEM: CoA synthesis EC Number: 4.1.1.30 Confidence Level: 0 AUTHORS: PMID:13163064 NOTES:
type: Reaction
name: N-((R)-Pantothenoyl)-L-cysteine carboxy-lyase Pantothenate and CoA biosynthesis EC:4.1.1.30

metaR FAS80COA L
reversible: false
product: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.85
type: Reaction
is: SBO:0000176
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110001#_eea52378_8a01_474c_a63a_a0a5f2ca68a6
has only substance units: false
is encoded by: hsa:1376
initial amount: NaN
name: CPT2
initial concentration: NaN
constant: false
boundary condition: true
type: Species
is: P23786
is: SBO:0000252

metaR EX ala L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-alanine
type: Reaction

metaR r0002
name: Active transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10460205,PMID:1296165,PMID:16288981,PMID:17466261,PMID:2199597,PMID:6219439,PMID:6361812,PMID:8353366 NOTES:
reactant: MODEL1310110001#
fast: false
reversible: true
kinetic law: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
is: SBO:0000185
is described by: ECO:0000000

metaR VLCSr
reversible: false
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
fast: false
name: Very-long-chain-fatty-acid-CoA ligase
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_f14c816c_2396_464d_be3b_588b2b949351
is: SBO:0000252
is encoded by: hsa:8818
initial concentration: NaN
constant: false
initial amount: NaN
name: DPM2
type: Species
has only substance units: false
boundary condition: true

metaR TYRCBOX
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: PMID:6131938 NOTES:SAB KEGG also says EC 4.1.1.28
is version of: http://identifiers.org/ec-code/4.1.1.28
name: L-Tyrosine carboxy-lyase
reversible: false
is described by: ECO:0000134
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
is: SBO:0000176

metaR GLB1
name: Beta-galactosidase
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NJ
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.4.16.5
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110001#
type: Reaction
reversible: false
is: SBO:0000176
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.6.4
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_eb6d00ef_0829_4cdb_b255_7cc81a442b93
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
name: PDE9A
initial concentration: NaN
type: Species
initial amount: NaN
is encoded by: hsa:5152

http://identifiers.org/biomodels.db/MODEL1310110001#_a8f28a4c_b76d_4fdf_95b5_aca389521d8e
is: Q13630
initial amount: NaN
constant: false
is encoded by: hsa:7264
type: Species
is: SBO:0000252
name: TSTA3
initial concentration: NaN
boundary condition: true
has only substance units: false

metaM asn L c
has only substance units: false
boundary condition: false
type: Species
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17196
constant: false
notes: FORMULA: C4H8N2O3 CHARGE: 0 INCHI: InChI=1S/C4H8N2O3/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H2,6,7)(H,8,9)/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00148
name: L-asparagine
is: HMDB00168
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_a61bc6a8_2201_4c8c_9f77_e217bdaacbc2
constant: false
name: ST3GAL3
boundary condition: true
is encoded by: hsa:6487
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
initial concentration: NaN

metaM mal L m
name: (S)-malate(2-)
constant: false
has only substance units: false
is: HMDB00156
is: CHEBI:15589
is: SBO:0000247
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
initial concentration: 1.0
initial amount: NaN
boundary condition: false
type: Species

metaR EX ura LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Uracil exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_2389831f_c0cf_45cf_8bb6_f86c6ba2adcc
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN
name: PYCRL
boundary condition: true
is encoded by: hsa:65263
is: Q53H96

metaR 4PYRDX
name: 4-Pyridoxal secretion
is described by: ECO:0000000
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
is: SBO:0000185
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:6380540 NOTES:IT Reaction correct??? (active transport)
reversible: false
type: Reaction

metaM nadh x
is: HMDB01487
initial amount: NaN
has only substance units: false
is: http://identifiers.org/pubchem.compound/3306
is: CHEBI:57945
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: Nicotinamide adenine dinucleotide - reduced
constant: false
type: Species
is: C00004

http://identifiers.org/biomodels.db/MODEL1310110001#_23b5f80b_5522_4a5b_8b40_8d3fc8c94f8e
boundary condition: true
initial concentration: NaN
is: Q9NX14
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is encoded by: hsa:54539
name: NDUFB11

metaR ABTD
product: MODEL1310110001#
fast: false
reversible: true
is described by: ECO:0000000
name: L-arabinitol 4-dehydrogenase
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.12 Confidence Level: 2 AUTHORS: PMID:12359133,PMID:13922173,PMID:15234337 NOTES:NCD
reactant: MODEL1310110001#

metaM ctdecdcoa m
boundary condition: false
is: C08277
initial concentration: 1.0
is: SBO:0000247
name: cis2trans4decadienoylcoa
has only substance units: false
is: HMDB00792
type: Species
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
constant: false
initial amount: NaN

metaR EX thymd LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thymidine exchange
type: Reaction

metaM lgnccoa x
initial concentration: 1.0
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
constant: false
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false
is: HMDB06526
name: lignocericyl coenzyme A
is: SBO:0000247

metaM occoa c
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
name: Octanoyl-CoA (n-C8:0CoA)
has only substance units: false
type: Species
is: HMDB01070
boundary condition: false
constant: false
is: CHEBI:57386
is: C01944
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM 3hbcoa m
name: (S)-3-hydroxybutanoyl-CoA(4-)
initial amount: NaN
type: Species
boundary condition: false
has only substance units: false
is: CHEBI:57316
constant: false
is: HMDB01166
is: SBO:0000247
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(33)8-16(35)54-7-6-27-15(34)4-5-28-23(38)20(37)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-19(49-51(39,40)41)18(36)24(48-14)32-12-31-17-21(26)29-11-30-22(17)32/h11-14,18-20,24,33,36-37H,4-10H2,1-3H3,(H,27,34)(H,28,38)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/p-4/t13-,14+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00686 EHMN_ABBREVIATION: C01144
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_eca4788c_48c7_4cda_9587_5d00ce5b30bf
name: COX7B
has only substance units: false
is encoded by: hsa:1349
type: Species
is: P24311
initial concentration: NaN
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252

metaM ksi pre20 g
is: CHEBI:28067
initial concentration: 1.0
type: Species
constant: false
name: keratan sulfate I biosynthesis, precursor 20
boundary condition: false
has only substance units: false
notes: FORMULA: C171H274N12O140S6X CHARGE: -7
is: SBO:0000247
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_d698e28d_12cd_40eb_a5c3_fe0eca804b08
initial amount: NaN
is encoded by: hsa:501
name: ALDH7A1
is: SBO:0000252
type: Species
initial concentration: NaN
constant: false
is: E7EPT3
has only substance units: false
boundary condition: true

metaR H2CO3D
name: carboxylic acid dissociation
product: MODEL1310110001#
is described by: ECO:0000000
reversible: true
fast: false
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.2.1.1
notes: GENE_ASSOCIATION: (761.1) or (771.1) or (377677.1) or (762.1) or (766.2) or (23632.1) or (766.1) or (771.2) or (759.1) or (768.1) or (760.1) SUBSYSTEM: Miscellaneous EC Number: 4.2.1.1 Confidence Level: 0 AUTHORS: PMID:11101628,PMID:11172051,PMID:11676494,PMID:14600151,PMID:7574487 NOTES:tv
type: Reaction

metaR r2310
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
product: MODEL1310110001#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
is: SBO:0000185
reactant: MODEL1310110001#
fast: false
type: Reaction
kinetic law: MODEL1310110001#
is described by: ECO:0000000

metaR GULN3D
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.45 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is: SBO:0000176
product: MODEL1310110001#
reversible: true
type: Reaction
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
name: L-gulonate 3-dehydrogenase

http://identifiers.org/biomodels.db/MODEL1310110001#_184f4a30_b348_466e_802f_e33c3857f51c
name: _AA664770_1_m
is encoded by: hsa:AA664770
constant: false
initial concentration: NaN
initial amount: NaN
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_f46a1986_6550_412c_97d7_64b51aa35a24
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
is encoded by: hsa:51102
is: Q9BV79
name: MECR

metaR RE1531M
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1531
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
reactant: MODEL1310110001#

metaR C100CPT1
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decanoylcarnitine
type: Reaction

metaR NCNt
name: Na+/Ca2+-NH4+ exchange
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (9187.1) or (25769.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10484410,PMID:10662833,PMID:11294880,PMID:12379639,PMID:14770312,PMID:9478004 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110001#
reversible: true
is described by: ECO:0000269
product: MODEL1310110001#
fast: false
is: SBO:0000185
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_517509fd_e08c_49f6_9fd8_333513b20070
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:8706
is: Q8TDY1
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
name: B3GALNT1

metaR URCN
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.2.1.49
is described by: ECO:0000269
product: MODEL1310110001#
fast: false
is: SBO:0000176
name: URCN
reversible: false
modifier: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (131669.1) SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:

metaM oretn n
boundary condition: false
initial concentration: 1.0
name: 4-oxo-retinoic acid
is: HMDB00224
has only substance units: false
notes: FORMULA: C20H27O3 CHARGE: -1 INCHI: InChI=1/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/p-1
is: CHEBI:58190
is: SBO:0000247
initial amount: NaN
constant: false
type: Species

metaR r1683
reactant: MODEL1310110001#
is: SBO:0000185
kinetic law: MODEL1310110001#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Y+LAT2 Utilized transport
product: MODEL1310110001#
is described by: ECO:0000000
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_4e400e6d_f343_4754_af27_50c731fbe8c1
is encoded by: hsa:1806
has only substance units: false
constant: false
is: Q12882
type: Species
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: DPYD

http://identifiers.org/biomodels.db/MODEL1310110001#_7180b00b_e6c0_45db_959f_47b3e9e1a953
is: B4DK61
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: ACOX1
type: Species
initial amount: NaN
boundary condition: true
constant: false
is encoded by: hsa:51

http://identifiers.org/biomodels.db/MODEL1310110001#_f7f1c8e9_3bf4_43e8_8daa_9df5396b8437
initial concentration: NaN
is: P33121
constant: false
name: ACSL1
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:2180

metaR r2311
kinetic law: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110001#
fast: false
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14

metaM arachcoa m
constant: false
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
name: arachidyl coenzyme A
is: CHEBI:15527
is: HMDB04258
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_6cca1324_dd34_41fc_9380_fe5f6a522563
initial concentration: NaN
constant: false
is: SBO:0000252
name: ACAA1
boundary condition: true
type: Species
is encoded by: hsa:30
is: Q96CA6
has only substance units: false
initial amount: NaN

metaM tetd7ecoa m
initial concentration: 1.0
constant: false
is: HMDB13109
type: Species
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: 7-tetradecenoylcoa
boundary condition: false

metaR SUCOAS1m
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (8802.1 and 8801.1) SUBSYSTEM: Citric acid cycle EC Number: 6.2.1.4 Confidence Level: 0 AUTHORS: PMID:9765291 NOTES:IF
is version of: http://identifiers.org/ec-code/6.2.1.4
fast: false
name: Succinate--CoA ligase (GDP-forming)
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
reversible: true
is: SBO:0000176
kinetic law: MODEL1310110001#

metaR CYTK3n
is: SBO:0000176
fast: false
reversible: true
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000269
name: cytidylate kinase (dCMP,CTP),nuclear

metaR r0160
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.6.1.51 Confidence Level: 0 AUTHORS: PMID:10347152,PMID:6469715 NOTES:
modifier: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
name: L-Serine:pyruvate aminotransferase Glycine, serine and threonine metabolism EC:2.6.1.51
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.1.3.2
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_af8f6554_904b_4803_838f_15c67244641a
has only substance units: false
is: SBO:0000252
constant: false
initial concentration: NaN
name: PIK3C2A
initial amount: NaN
is encoded by: hsa:5286
type: Species
is: O00443
boundary condition: true

metaM 3oddcoa m
is: CHEBI:27868
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB03937
has only substance units: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
constant: false
name: 3-Oxododecanoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110001#_78b595c7_6b5f_409a_a840_ea2992b3e0cf
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000252
is encoded by: hsa:4967
boundary condition: true
name: OGDH
initial concentration: NaN
type: Species
is: Q02218

http://identifiers.org/biomodels.db/MODEL1310110001#_8ecd24b2_4e47_448f_9e68_b24919c0c4b7
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:2629
name: GBA

metaM dcsptn1coa m
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h8-9,11-12,14-15,17-18,20-21,30-32,36-38,42,53-54H,4-7,10,13,16,19,22-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/b9-8-,12-11-,15-14-,18-17-,21-20-/t32-,36-,37?,38+,42-/m1/s1
is: C16173
constant: false
has only substance units: false
is: HMDB06513
initial amount: NaN
initial concentration: 1.0
type: Species
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A
is: http://identifiers.org/pubchem.compound/47205483
is: SBO:0000247
boundary condition: false

metaM dtdp m
is: HMDB01274
boundary condition: false
initial amount: NaN
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: C00363
is: CHEBI:58369
has only substance units: false
name: dTDP
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363

http://identifiers.org/biomodels.db/MODEL1310110001#_46dad0e6_b6b3_420b_8880_37bd8e19dc86
constant: false
boundary condition: true
name: MPI
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: P34949
is encoded by: hsa:4351

metaR r1681
fast: false
kinetic law: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#
is: SBO:0000185
name: Y+LAT2 Utilized transport

metaR r0584
fast: false
is: SBO:0000176
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.2.1.5
product: MODEL1310110001#
modifier: MODEL1310110001#
name: Deamino-NAD+ nucleotidohydrolase Nicotinate and nicotinamide metabolism EC:3.6.1.9
type: Reaction
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: NAD metabolism EC Number: 3.6.1.9 Confidence Level: 0 AUTHORS: PMID:11579996,PMID:11946484 NOTES:
reactant: MODEL1310110001#

metaM 4ppan c
is: HMDB01016
name: D-4'-Phosphopantothenate
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
is: CHEBI:10986
boundary condition: false
is: C03492
notes: FORMULA: C9H15NO8P CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01127 EHMN_ABBREVIATION: C03492
initial concentration: 1.0
constant: false

metaR r2538
reactant: MODEL1310110001#
reversible: true
type: Reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: Utilized transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
is: SBO:0000185

metaR LEUTA
name: leucine transaminase
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.42
reactant: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (586.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:_2.6.1.42
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
reversible: true

metaR r2312
reactant: MODEL1310110001#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
reversible: true
product: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000185
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:

metaM nadh m
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial concentration: 1.0
is: HMDB01487
name: Nicotinamide adenine dinucleotide - reduced
is: http://identifiers.org/pubchem.compound/3306
boundary condition: false
is: CHEBI:57945
is: C00004
initial amount: NaN

metaR EX ivcrn
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for isovaleryl carnitine
type: Reaction

metaR ADK3
is version of: http://identifiers.org/ec-code/2.7.4.3
reversible: true
name: adentylate kinase (GTP)
product: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:9434148 NOTES:JLR
fast: false
reactant: MODEL1310110001#
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110001#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_ff0b992e_3cb7_441a_adbd_bdb2586b06b7
initial concentration: NaN
is: G0W2N5
has only substance units: false
name: SLC14A1
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true
is encoded by: hsa:6563

metaR ACGAMtly
reactant: MODEL1310110001#
name: N-acetyl-glucosamine lysosomal efflux
kinetic law: MODEL1310110001#
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:2784441,PMID:3753439 NOTES:NCD
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110001#
type: Reaction

metaR r1682
type: Reaction
modifier: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110001#
reversible: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110001#

metaM hs deg11 l
constant: false
initial amount: NaN
notes: FORMULA: C55H81N3O67S7 CHARGE: -8
name: heparan sulfate, degradation product 11
is: HMDB00868
initial concentration: 1.0
is: CHEBI:57737
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false

metaR r2539
is: SBO:0000185
reactant: MODEL1310110001#
name: Postulated transport reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction

metaM arachcoa c
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041
boundary condition: false
is: HMDB04258
is: CHEBI:15527
has only substance units: false
initial amount: NaN
constant: false
type: Species
initial concentration: 1.0
is: SBO:0000247
name: arachidyl coenzyme A

metaR FAOXC221C201x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:1-->C20:1)x
type: Reaction

metaR FACOAL184
kinetic law: MODEL1310110001#
product: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
reversible: true
name: fatty-acid--CoA ligase
modifier: MODEL1310110001#
reactant: MODEL1310110001#

metaR r2313
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
reactant: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
product: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110001#_cb4e9935_a6be_4982_928b_ee52ae4b4453
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:51181
has only substance units: false
is: Q7Z4W1
type: Species
constant: false
initial concentration: NaN
name: DCXR

metaR 3SALAASPm
is: SBO:0000185
reactant: MODEL1310110001#
type: Reaction
fast: false
product: MODEL1310110001#
reversible: true
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (10165.1) or (8604.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:14598172 NOTES:PMID:486467 MM
name: cysteinesulfinate-aspartate mitochondrial shuttle

http://identifiers.org/biomodels.db/MODEL1310110001#_ba2a7e75_ded4_4780_87bb_37748d10bb54
is encoded by: hsa:278
initial amount: NaN
is: P04745
has only substance units: false
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
name: AMY1C
type: Species

metaR SFGTH
notes: GENE_ASSOCIATION: (2098.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.1.2.12 Confidence Level: 4 AUTHORS: PMID:4436331,PMID:8460164 NOTES:NCD
reactant: MODEL1310110001#
reversible: true
is described by: ECO:0000269
name: S-Formylglutathione hydralase
fast: false
modifier: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.2.12
kinetic law: MODEL1310110001#
is: SBO:0000176

metaR SQLSr
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Cholesterol metabolism EC Number: 2.5.1.21 Confidence Level: 4 AUTHORS: PMID:1318747 NOTES:This is a lumped reaction: Rxn 1: 2 frdp -> 2 ppi + presqualene diphosphate Rxn 2: presqualene diphosphate + NADPH -> squalene + NADP NCD ER version - NJ
is: SBO:0000176
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/2.5.1.21
reactant: MODEL1310110001#
fast: false
reversible: false
name: Squalene synthase
type: Reaction

metaR r2314
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
type: Reaction
is: SBO:0000185
is described by: ECO:0000000
reversible: true
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
fast: false

metaR ST8SIA51g
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (29906.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.4.99.8 Confidence Level: 4 AUTHORS: PMID:9199191 NOTES:NJ
product: MODEL1310110001#
name: Beta-galactoside alpha-2,3-sialyltransferase
kinetic law: MODEL1310110001#
type: Reaction
reversible: false
fast: false
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110001#

metaM 3spyr c
initial concentration: 1.0
type: Species
is: SBO:0000247
name: 3-sulfonatopyruvate(2-)
notes: FORMULA: C3H2O6S CHARGE: -2 INCHI: InChI=1S/C3H4O6S/c4-2(3(5)6)1-10(7,8)9/h1H2,(H,5,6)(H,7,8,9)/p-2 EHMN_ABBREVIATION: C05528
boundary condition: false
is: CHEBI:57940
is: HMDB04045
has only substance units: false
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_eee90269_5083_410c_814c_392503386a9e
boundary condition: true
is: E9PDK1
is encoded by: hsa:83697
name: SLC4A9
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN

metaR EX cbasp LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of N-carbamoyl-L-aspartate
type: Reaction

metaM hs deg18 l
type: Species
is: HMDB01352
is: SBO:0000247
notes: FORMULA: C43H66N2O45S3 CHARGE: -4
is: CHEBI:17180
initial concentration: 1.0
constant: false
has only substance units: false
name: heparan sulfate, degradation product 18
boundary condition: false
initial amount: NaN

metaR EX biocyt LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biocytin exchange
type: Reaction

metaR ADK1
reversible: true
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: adenylate kinase
notes: GENE_ASSOCIATION: (122481.1) or (203.1) or (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
modifier: MODEL1310110001#
fast: false
type: Reaction
reactant: MODEL1310110001#
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3

metaR PGISr
is version of: http://identifiers.org/ec-code/5.3.99.4
type: Reaction
notes: GENE_ASSOCIATION: (5740.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.4 Confidence Level: 4 AUTHORS: PMID:2120373,PMID:2491846 NOTES:NJ
name: Prostaglandin I2 synthase
modifier: MODEL1310110001#
reactant: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
fast: false
product: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176

metaR GLCt1r
kinetic law: MODEL1310110001#
product: MODEL1310110001#
fast: false
is: SBO:0000185
modifier: MODEL1310110001#
reversible: true
type: Reaction
reactant: MODEL1310110001#
is described by: ECO:0000269
name: glucose transport (uniport)
notes: GENE_ASSOCIATION: (66035.1) or (6517.1) or (56606.1) or (154091.1) or (6513.1) or (11182.1) or (29988.1) or (6514.1) or (155184.1) or (56606.2) or (144195.1) or (6515.1) or (81031.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:10821868,PMID:10860667,PMID:10860996,PMID:10970791,PMID:11247674,PMID:11583593,PMID:11592815,PMID:11780753,PMID:11832379,PMID:11882499,PMID:12135767,PMID:12483288,PMID:12504846,PMID:12750891,PMID:12914765,PMID:14739288,PMID:15033637,PMID:1701966,PMID:2182619,PMID:2656669,PMID:3103217,PMID:3170580,PMID:3399500,PMID:3839598,PMID:7926364,PMID:8504756,PMID:9230074,PMID:9770484 NOTES:

metaM dtdp n
type: Species
initial concentration: 1.0
is: HMDB01274
initial amount: NaN
boundary condition: false
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: CHEBI:58369
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate
is: SBO:0000247
constant: false

metaM retinal cis 13 r
initial concentration: 1.0
is: CHEBI:45487
initial amount: NaN
name: 13-cis-retinal
notes: FORMULA: C20H28O CHARGE: 0 INCHI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13- EHMN_ABBREVIATION: CE5589
is: HMDB06220
type: Species
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_b0c94cc5_523c_4cf9_8128_4bc343233e2c
is encoded by: hsa:43
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
constant: false
name: ACHE

http://identifiers.org/biomodels.db/MODEL1310110001#_54bdc289_6390_4c12_b327_11cf01d1dbde
constant: false
is: SBO:0000252
is: Q7KZA3
is encoded by: hsa:2235
boundary condition: true
type: Species
initial amount: NaN
name: FECH
initial concentration: NaN
has only substance units: false

metaM prist c
constant: false
initial concentration: 1.0
type: Species
initial amount: NaN
boundary condition: false
is: HMDB00795
is: SBO:0000247
notes: FORMULA: C19H37O2 CHARGE: -1 INCHI: InChI=1S/C19H38O2/c1-15(2)9-6-10-16(3)11-7-12-17(4)13-8-14-18(5)19(20)21/h15-18H,6-14H2,1-5H3,(H,20,21)
name: pristanic acid
is: CHEBI:51340
has only substance units: false

metaR S6T17g
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
fast: false
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reversible: false

metaM HC02121 c
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
has only substance units: false
initial amount: NaN
type: Species
is: CHEBI:58758
notes: FORMULA: C11H18N3O7S CHARGE: -1 INCHI: InChI=1S/C11H19N3O7S/c12-6(11(20)21)1-2-8(16)14-7(4-22-5-15)10(19)13-3-9(17)18/h6-7,15H,1-5,12H2,(H,13,19)(H,14,16)(H,17,18)(H,20,21)/p-1/t6-,7-/m0/s1 EHMN_ABBREVIATION: C14180
name: S-(hydroxymethyl)glutathione(1-)

metaR r2315
type: Reaction
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is described by: ECO:0000000
reversible: true
is: SBO:0000185

metaR RE1520M
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
name: RE1520
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.35
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) or (1962.1) or (3032.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is: SBO:0000176
fast: false

metaR DOLP Uter
kinetic law: MODEL1310110001#
fast: false
product: MODEL1310110001#
is described by: ECO:0000000
reversible: false
name: dolichol phosphate flippase (uterus)
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction
reactant: MODEL1310110001#

metaR r2420
kinetic law: MODEL1310110001#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.7
type: Reaction
product: MODEL1310110001#
reversible: true
fast: false
is described by: ECO:0000000
reactant: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10585886,PMID:14598172,PMID:4424886,PMID:4441366,PMID:5099217,PMID:8329439 NOTES:

metaM glyald c
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01051
is: CHEBI:17378
constant: false
notes: FORMULA: C3H6O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00436 EHMN_ABBREVIATION: C00577
is: C00577
initial amount: NaN
initial concentration: 1.0
name: D-Glyceraldehyde
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_b0c5e08c_62dc_41ae_bded_79119fe5df81
has only substance units: false
is encoded by: hsa:122622
boundary condition: true
initial concentration: NaN
is: B3KTV4
is: SBO:0000252
constant: false
name: ADSSL1
type: Species
initial amount: NaN

metaM ksi pre36 g
boundary condition: false
notes: FORMULA: C247H394N17O210S11X CHARGE: -12
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:28067
type: Species
name: keratan sulfate I biosynthesis, precursor 36
constant: false

metaR r2316
product: MODEL1310110001#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reversible: true
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:

metaR FAOXC226205x
is version of: http://identifiers.org/ec-code/1.3.3.6
name: Beta oxidation of long chain fatty acid
reactant: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
kinetic law: MODEL1310110001#
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/4.2.1.107
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/1.1.1.35
is: SBO:0000176
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110001#_26774174_66a4_4917_aeec_a0b09e096288
is: SBO:0000252
is encoded by: hsa:2544
boundary condition: true
type: Species
constant: false
name: _2544_1_c
has only substance units: false
initial concentration: NaN
initial amount: NaN

metaR SARDHm
notes: GENE_ASSOCIATION: (1757.1) SUBSYSTEM: Urea cycle EC Number: 1.5.99.2 Confidence Level: 4 AUTHORS: PMID:10444331 NOTES:SAB EC # is questionable overall reaction is questionable
modifier: MODEL1310110001#
name: Sarcosine dehydrogenase (m)
reversible: false
is version of: http://identifiers.org/ec-code/1.5.99.1
fast: false
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_b8fe32cc_3d8a_46e2_b8a9_1b0a7ae1066b
is encoded by: hsa:9377
is encoded by: hsa:9167
is encoded by: hsa:1350
has part: H0UI06
is encoded by: hsa:1347
has part: Q6YFQ2
has part: Q96KJ9
has part: P00414
is encoded by: hsa:84701
has part: Q02221
has part: P13073
is encoded by: hsa:1337
has part: P14854
has only substance units: false
is encoded by: hsa:1340
is encoded by: hsa:125965
initial concentration: NaN
is encoded by: hsa:1339
has part: Q7GXZ8
has part: Q6FGA0
is encoded by: hsa:1346
initial amount: NaN
has part: Q7GXY8
is encoded by: hsa:1329
is encoded by: hsa:1349
is: SBO:0000297
name: COX6B2:COX4I1:COX5B:COX6A1:COX6A2:COX6B1:COX6C:COX7A1:COX7A2:COX7B:COX7C:COX8A:COX7B2:COX8C:COX1:COX2:COX3:COX4I2:COX7A2L:COX5A
is encoded by: hsa:1351
is encoded by: hsa:170712
is encoded by: hsa:341947
has part: Q53YB7
has part: P09669
has part: P15954
is encoded by: hsa:4513
has part: P24311
has part: Q53XN1
is encoded by: hsa:1327
has part: Q8TF08
has part: Q7Z4L0
type: Species
has part: P12074
has part: P20674
constant: false
boundary condition: true
is encoded by: hsa:4512
is encoded by: hsa:1345
has part: P24310
is encoded by: hsa:4514

metaR FAOXC18280m
is: SBO:0000176
type: Reaction
modifier: MODEL1310110001#
reversible: false
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
name: Beta oxidation of fatty acid
reactant: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:c18:2, transe -> c8:0 - 5 rounds of beta ox, lose 2 degrees of unsat - only 3 fad oxidized 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
is version of: http://identifiers.org/ec-code/1.3.99.3

metaR PItg
fast: false
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
name: phosphate transport, Golgi apparatus
kinetic law: MODEL1310110001#
type: Reaction
reversible: false

metaR C102CPT1
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decadienoylcarnitine
type: Reaction

metaR FAEL183
name: fatty-acyl-CoA elongation (n-C18:3CoA)
is: SBO:0000176
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (6785.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11138005,PMID:15189125 NOTES:fatty acid elongation step NJ
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
is described by: ECO:0000000
product: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_03217603_ad3c_4c1a_b61a_d1cac6b8fbb7
is encoded by: hsa:83549
is: SBO:0000252
name: UCK1
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: Q5JT09

metaR EX ade LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Adenine exchange
type: Reaction

metaR INSt
reversible: true
modifier: MODEL1310110001#
type: Reaction
fast: false
is described by: ECO:0000269
is: SBO:0000185
name: Inosine transport (diffusion)
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422 NOTES:AR
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_60a01583_2574_40c9_a00f_60ad09793736
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
type: Species
is: P25705
is encoded by: hsa:498
boundary condition: true
name: ATP5A1

metaR THYMt
is described by: ECO:0000269
kinetic law: MODEL1310110001#
is: SBO:0000185
name: thymine reversible transport via facilated diffusion
reactant: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:IT
modifier: MODEL1310110001#
fast: false
type: Reaction
reversible: true

metaR ENGASE3ly
is described by: ECO:0000000
product: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000176
name: endo-beta-N-acetylglucosaminidase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.96 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false

metaM tetdecdicoa m
type: Species
is: SBO:0000247
name: 5,8-tetradecadienoylcoa
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
is: HMDB02288
boundary condition: false
has only substance units: false

metaR r2317
kinetic law: MODEL1310110001#
type: Reaction
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
product: MODEL1310110001#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
is: SBO:0000185
is described by: ECO:0000000
reversible: true

metaR LINKDEG4ly
is described by: ECO:0000000
kinetic law: MODEL1310110001#
name: degradation of proteoglycan linkage region, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
product: MODEL1310110001#
is: SBO:0000176
fast: false
reversible: false
type: Reaction
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_7126a63e_576b_482b_9fe6_cc657b0ee954
type: Species
name: SULT1A1
initial amount: NaN
is encoded by: hsa:6817
is: SBO:0000252
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_b0727b63_b499_4db9_b9c1_71e0cd3b73cf
is: Q9NRD8
is encoded by: hsa:50506
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false
type: Species
name: DUOX2
is: SBO:0000252
boundary condition: true

metaM mal L e
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:15589
name: (S)-malate(2-)
is: HMDB00156
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1

metaR EX cspg b LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan exchange
type: Reaction

metaM HC02217 c
constant: false
boundary condition: false
is: CHEBI:27647
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial concentration: 1.0
name: prostaglandin-g2
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_907a936c_9279_42ae_b3ce_d3c72c47ba51
initial concentration: NaN
boundary condition: true
is encoded by: hsa:36
constant: false
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
name: ACADSB
is: P45954

metaR ACNAMPH
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: 3.1.3.29 Confidence Level: 2 AUTHORS: NOTES:NCD
product: MODEL1310110001#
name: N-Acetylneuraminate 9-phosphate phosphohydrolase
reactant: MODEL1310110001#
type: Reaction
fast: false
reversible: false
kinetic law: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000176

metaR 5MTAte
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000134
name: Transport of 5-S-methyl-5-thioadenosine
reversible: true
is: SBO:0000185
fast: false

metaR 5ADTSTSTERONESULT
product: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (6822.1) SUBSYSTEM: Steroid metabolism EC Number: 2.8.2.2 Confidence Level: 4 AUTHORS: PMID:1588921,PMID:16399349 NOTES:NJ
is version of: http://identifiers.org/ec-code/2.8.2.14
kinetic law: MODEL1310110001#
reversible: false
name: 5alpha-Dihydrotestosterone sulfotransferase
modifier: MODEL1310110001#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110001#
is described by: ECO:0000269

metaM 34dhmald c
is: HMDB06242
type: Species
name: 3,4-Dihydroxymandelaldehyde
constant: false
is: http://identifiers.org/pubchem.compound/7903
has only substance units: false
boundary condition: false
is: C05577
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577

metaR EICOSTETCRNt
reversible: false
name: transport into the mitochondria (carnitine)
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110001#
fast: false
is: SBO:0000185
kinetic law: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_82a661a8_1e1a_41db_8649_0a24f46753a7
is: SBO:0000252
is: E9PB82
boundary condition: true
initial concentration: NaN
type: Species
constant: false
name: HSD17B4
is encoded by: hsa:3295
has only substance units: false
initial amount: NaN

metaM tmndnc c
constant: false
initial amount: NaN
type: Species
boundary condition: false
is: HMDB01999
initial concentration: 1.0
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
is: http://identifiers.org/pubchem.compound/446284
name: timnodonic acid C20:5, n-3
has only substance units: false
is: SBO:0000247

metaM 3oddcoa x
type: Species
name: 3-Oxododecanoyl-CoA
is: CHEBI:27868
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h19-20,22,26-28,32,44-45H,4-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01402 EHMN_ABBREVIATION: C05263
boundary condition: false
is: SBO:0000247
constant: false
is: HMDB03937
initial concentration: 1.0
has only substance units: false
initial amount: NaN

metaR r2318
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
type: Reaction
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
reversible: true
is described by: ECO:0000000
product: MODEL1310110001#
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#

metaR PETHCT
name: phosphoethanolamine cytidyltransferase
is described by: ECO:0000269
modifier: MODEL1310110001#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.7.7.14
product: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (5833.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.7.14 Confidence Level: 4 AUTHORS: NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#

metaM gpi hs r
name: {[PE-Man-],[PE-]Man},{PE-}Man-GlcN-acylPI
is: SBO:0000247
is: CHEBI:16240
constant: false
type: Species
initial concentration: 1.0
is: HMDB03125
initial amount: NaN
has only substance units: false
boundary condition: false
notes: FORMULA: C55H106N4O38P4FULLRCO2FULLR2CO2 CHARGE: 0

metaR O2Stm
reversible: true
product: MODEL1310110001#
name: superoxide anion transport via diffusion (mitochondria)
reactant: MODEL1310110001#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
kinetic law: MODEL1310110001#
is described by: ECO:0000000
type: Reaction

metaR EX strdnc LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: stearidonic acid exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_25c3a2be_37df_4375_8a0e_4da06d25dbe0
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN
name: UGCG
boundary condition: true
is encoded by: hsa:7357
is: Q16739
type: Species
has only substance units: false

metaR FAOXC16080m
reactant: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.8.1
product: MODEL1310110001#
is described by: ECO:0000269
name: Beta oxidation of long chain fatty acid
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_4 rounds of beta ox c16:0 -> c8:0, 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
kinetic law: MODEL1310110001#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3

metaM mal L c
boundary condition: false
is: CHEBI:15589
initial amount: NaN
initial concentration: 1.0
type: Species
is: HMDB00156
notes: FORMULA: C4H4O5 CHARGE: -2 INCHI: InChI=1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/p-2/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00146
has only substance units: false
is: SBO:0000247
constant: false
name: (S)-malate(2-)

metaR NDPK1m
type: Reaction
modifier: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
product: MODEL1310110001#
is described by: ECO:0000254
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
fast: false

metaR TSTSTERONEt
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: 2.8.2.2 Confidence Level: 2 AUTHORS: PMID:1588921,PMID:16399349 NOTES:
name: Testosterone transport
product: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000185
type: Reaction
reversible: true
is described by: ECO:0000269
fast: false

metaM ksii core4 pre3 g
is: SBO:0000247
has only substance units: false
name: keratan sulfate II biosynthesis, precursor 3
is: HMDB00175
initial amount: NaN
is: C00130
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C55H89N5O38X CHARGE: -1
boundary condition: false
is: CHEBI:58053

http://identifiers.org/biomodels.db/MODEL1310110001#_7f6865ac_1a57_45f6_9be2_b28a941a9567
initial concentration: NaN
initial amount: NaN
has only substance units: false
constant: false
is: P54709
type: Species
is: SBO:0000252
name: ATP1B3
is encoded by: hsa:483
boundary condition: true

metaM pail5p hs c
initial amount: NaN
boundary condition: false
has only substance units: false
name: 1-phosphatidyl-1D-myo-inositol 5-phosphate(3-)
is: SBO:0000247
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2 CHARGE: -3
constant: false
initial concentration: 1.0
type: Species
is: CHEBI:57795

metaM HC00229 e
is: SBO:0000247
boundary condition: false
notes: FORMULA: C12H22O11 CHARGE: 0 INCHI: InChI=1S/C12H22O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 EHMN_ABBREVIATION: C00252
has only substance units: false
is: CHEBI:28189
type: Species
initial amount: NaN
initial concentration: 1.0
constant: false
name: Isomaltose

metaM pail35p hs c
is: CHEBI:57923
type: Species
is: SBO:0000247
initial amount: NaN
name: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate(5-)
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2 CHARGE: -5
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false

metaR r2319
reactant: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.2
fast: false
type: Reaction
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_b483403a_fc62_42e1_a7c8_1a6772341736
is encoded by: hsa:4717
is: SBO:0000252
initial concentration: NaN
constant: false
boundary condition: true
name: NDUFC1
type: Species
initial amount: NaN
is: O43677
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_f3ded333_7af9_437d_8e7a_e3013ab24c3d
boundary condition: true
is: Q9BYV1
initial concentration: NaN
name: AGXT2
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:64902
type: Species
initial amount: NaN

metaM datp m
is: C00131
name: dATP
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
is: HMDB01532
type: Species
is: CHEBI:61404
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_4390d8ea_f33d_4d13_af8f_357efe0c600b
is encoded by: hsa:5136
has only substance units: false
initial amount: NaN
name: PDE1A
constant: false
is: Q9Y633
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM bamppald c
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01106
type: Species
is: http://identifiers.org/pubchem.compound/7975
notes: FORMULA: C3H8NO CHARGE: 1 INCHI: InChI=1/C3H7NO/c4-2-1-3-5/h3H,1-2,4H2 EHMN_ABBREVIATION: C05665
has only substance units: false
is: C05665
initial concentration: 1.0
name: beta-Aminopropion aldehyde

metaM HC02217 e
constant: false
has only substance units: false
is: CHEBI:27647
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C20H31O6 CHARGE: -1 INCHI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1 EHMN_ABBREVIATION: C05956
initial amount: NaN
is: SBO:0000247
name: prostaglandin-g2
type: Species

metaR O2Stn
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
name: superoxide anion transport via diffusion (nucleus)
is: SBO:0000185
product: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#

metaR EX pnto R LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: (R)-Pantothenate exchange
type: Reaction

metaR r0587
kinetic law: MODEL1310110001#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Unassigned EC Number: 3.1.3.41 Confidence Level: 0 AUTHORS: PMID:11797369,PMID:1730777,PMID:388794 NOTES:
name: 4-Nitrophenyl phosphate phosphohydrolase gamma-Hexachlorocyclohexane degradation EC:3.1.3.2 EC:3.1.3.41 EC:3.1.3.1
is described by: ECO:0000000
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.2.1.5
type: Reaction
reversible: true
product: MODEL1310110001#

metaR NDPK1n
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:15242782 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
type: Reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000176
reactant: MODEL1310110001#
is described by: ECO:0000134
fast: false
modifier: MODEL1310110001#
name: nucleoside-diphosphate kinase (ATP:GDP), nuclear
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110001#_c918afc5_6c15_4668_9baa_2170620beb17
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
is: Q5JT09
initial amount: NaN
name: UCK1
has only substance units: false
type: Species
is encoded by: hsa:83549

metaM tmndnc e
has only substance units: false
initial amount: NaN
is: HMDB01999
type: Species
boundary condition: false
is: http://identifiers.org/pubchem.compound/446284
initial concentration: 1.0
notes: FORMULA: C20H29O2 CHARGE: -1 INCHI: InChI=1/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
name: timnodonic acid C20:5, n-3
is: SBO:0000247
constant: false

metaM doco13ac e
constant: false
type: Species
initial amount: NaN
is: HMDB02068
is: SBO:0000247
name: docosenoic acid (C22:1)
boundary condition: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C22H41O2 CHARGE: -1

metaM ksii core4 deg2 l
is: SBO:0000247
initial amount: NaN
constant: false
is: CHEBI:12936
is: HMDB00143
notes: FORMULA: C78H127N6O61S2X CHARGE: -2
type: Species
name: keratan sulfate II (core 4-linked), degradation product 2
has only substance units: false
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_892f1fbc_8e56_48ff_962e_ba95f28afb05
type: Species
initial concentration: NaN
has only substance units: false
is: P14618
constant: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:5315
name: PKM2
is: SBO:0000252

metaR EX retn LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Retinoate exchange
type: Reaction

metaM dhcholestancoa r
initial concentration: 1.0
boundary condition: false
initial amount: NaN
type: Species
is: HMDB02159
constant: false
is: SBO:0000247
is: CHEBI:15494
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA
notes: FORMULA: C48H76N7O19P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O19P3S/c1-26(30-10-11-31-36-32(13-16-48(30,31)6)47(5)15-12-29(56)20-28(47)21-33(36)57)8-7-9-27(2)45(62)78-19-18-50-35(58)14-17-51-43(61)40(60)46(3,4)23-71-77(68,69)74-76(66,67)70-22-34-39(73-75(63,64)65)38(59)44(72-34)55-25-54-37-41(49)52-24-53-42(37)55/h24-34,36,38-40,44,56-57,59-60H,7-23H2,1-6H3,(H,50,58)(H,51,61)(H,66,67)(H,68,69)(H2,49,52,53)(H2,63,64,65)/t26-,27?,28+,29-,30-,31+,32+,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01332 EHMN_ABBREVIATION: C04644
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_800855b3_b475_44eb_9b1e_6fd750f3dda5
name: ALDOB
constant: false
type: Species
is: SBO:0000252
is: P05062
is encoded by: hsa:229
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true

metaM occoa x
initial amount: NaN
has only substance units: false
is: CHEBI:57386
name: Octanoyl-CoA (n-C8:0CoA)
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
is: HMDB01070
is: SBO:0000247
is: C01944

metaR EX CLPND LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: clupanodonic acid (docosapentaenoic (n-3)) exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_468d7f47_4c70_4907_9708_1ec97344569a
is: SBO:0000252
boundary condition: true
initial concentration: NaN
type: Species
is: Q9UN42
has only substance units: false
is encoded by: hsa:23439
constant: false
initial amount: NaN
name: ATP1B4

metaR r0472
is: SBO:0000176
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
product: MODEL1310110001#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
is described by: ECO:0000000
reversible: true

metaR EHGLATm
modifier: MODEL1310110001#
is described by: ECO:0000212
type: Reaction
is version of: http://identifiers.org/ec-code/2.6.1.1
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase, mitochondrial
fast: false
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.1 Confidence Level: 1 AUTHORS: PMID:15849464 NOTES:NCD
reversible: false
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#

metaR EX fuc L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Fucose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_6e846974_2670_4dcf_8302_0562f33e6947
initial amount: NaN
is: Q96T66
has only substance units: false
is encoded by: hsa:349565
name: NMNAT3
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
constant: false

metaR RE3006M
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433 NOTES:
type: Reaction
product: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE3006
kinetic law: MODEL1310110001#
is: SBO:0000176
reversible: true
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17

metaM hdcea e
boundary condition: false
name: Hexadecenoate (n-C16:1)
constant: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:32372
has only substance units: false
type: Species
is: HMDB03229
initial amount: NaN

metaR VD3
kinetic law: MODEL1310110001#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin D metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8392061 NOTES:This reaction takes place in skin and needs body temperature based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.194 IT
name: Vitamin D3 formation
fast: false
type: Reaction
reactant: MODEL1310110001#
reversible: true
is: SBO:0000176
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_3a100878_900a_437e_90cb_cd11bf78213e
has only substance units: false
boundary condition: true
is encoded by: hsa:7296
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
constant: false
name: TXNRD1

metaM cdp c
is: HMDB01546
is: SBO:0000247
notes: FORMULA: C9H12N3O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00110 EHMN_ABBREVIATION: C00112
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
is: C00112
name: CDP
is: CHEBI:58069
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_7751df89_cd4d_4e22_ab93_1f18d01acd48
initial concentration: NaN
boundary condition: true
constant: false
is encoded by: hsa:80864
initial amount: NaN
name: EGFL8
is: SBO:0000252
has only substance units: false
is: Q99944
type: Species

metaM lgnccoa c
boundary condition: false
has only substance units: false
name: lignocericyl coenzyme A
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
notes: FORMULA: C45H78N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H82N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h32-34,38-40,44,55-56H,4-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/t34-,38?,39-,40+,44-/m1/s1
is: HMDB06526
is: SBO:0000247

metaR EX hestratriol LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4,17 dihydroxy estradiol exchange
type: Reaction

metaR TMNDNCCRNt
is described by: ECO:0000000
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: transport into the mitochondria (carnitine)
fast: false
kinetic law: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
reversible: false
is: SBO:0000185
reactant: MODEL1310110001#

metaR H2Ot
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
name: H2O transport via diffusion
notes: GENE_ASSOCIATION: (6523.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11024018,PMID:11034615,PMID:12748858,PMID:2490366,PMID:8063771 NOTES:renamed from H20t5 to H2Ot NCD
modifier: MODEL1310110001#
is described by: ECO:0000269
fast: false
type: Reaction
reversible: true
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110001#_c5805832_7450_4dcd_bd04_96cfea412638
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:10005
boundary condition: true
is: O14734
type: Species
is: SBO:0000252
initial amount: NaN
name: ACOT8

metaM glyc S e
name: (S)-Glycerate
constant: false
notes: FORMULA: C3H5O4 CHARGE: 0
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:33871
initial amount: NaN
is: SBO:0000247
is: HMDB06372

metaR SRTNtu
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12883891 NOTES:SAB electrogenic, Na indepdendent & rev NJ
fast: false
reversible: true
kinetic law: MODEL1310110001#
type: Reaction
name: Serotonin uniport
product: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000269
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_7fea871b_4a5c_46f7_8409_1741942daa50
is: P49753
initial concentration: NaN
type: Species
boundary condition: true
is: SBO:0000252
name: ACOT2
initial amount: NaN
is encoded by: hsa:10965
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_5a6e40ff_ae89_485f_b02e_7efb2ac456a6
is: SBO:0000252
initial amount: NaN
has only substance units: false
boundary condition: true
type: Species
is: P31639
name: SLC5A2
constant: false
is encoded by: hsa:6524
initial concentration: NaN

metaM dtdp e
is: HMDB01274
boundary condition: false
initial amount: NaN
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 INCHI: InChI=1S/C10H16N2O11P2/c1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(22-8)4-21-25(19,20)23-24(16,17)18/h3,6-8,13H,2,4H2,1H3,(H,19,20)(H,11,14,15)(H2,16,17,18)/p-3/t6-,7+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:58369
type: Species
constant: false
has only substance units: false
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate

http://identifiers.org/biomodels.db/MODEL1310110001#_1badec9d_8ce9_4149_b848_fd28f45160da
boundary condition: true
is: Q92185
name: ST8SIA1
type: Species
is encoded by: hsa:6489
has only substance units: false
initial amount: NaN
is: SBO:0000252
constant: false
initial concentration: NaN

metaR CYTK11n
type: Reaction
reactant: MODEL1310110001#
reversible: true
name: cytidylate kinase (dCMP,dGTP),nuclear
fast: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_16b303cf_8356_48b0_a413_db59c70aa2ff
is encoded by: hsa:1629
name: DBT
boundary condition: true
type: Species
has only substance units: false
constant: false
initial amount: NaN
is: P11182
initial concentration: NaN
is: SBO:0000252

metaR FOLR2
modifier: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176
name: folate reductase
is version of: http://identifiers.org/ec-code/1.5.1.3
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000254
product: MODEL1310110001#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_c3aeb329_e760_461c_887f_129bd2ff60fd
initial amount: NaN
is encoded by: hsa:411
is: SBO:0000252
is: A8K4A0
type: Species
name: ARSB
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false

metaM CE0713 m
is: HMDB02329
constant: false
type: Species
name: 3-oxolinoleoyl-CoA
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C39H60N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H64N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h8-9,11-12,25-26,28,32-34,38,50-51H,4-7,10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b9-8-,12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE0713
initial amount: NaN
is: CHEBI:30623
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_b1e19899_bd9d_43cd_8842_1bd5f0afb9d1
is encoded by: hsa:79053
is: Q9BVK2
has only substance units: false
is: SBO:0000252
name: ALG8
boundary condition: true
initial concentration: NaN
constant: false
type: Species
initial amount: NaN

metaM 34hpp m
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
constant: false
name: 3-(4-hydroxyphenyl)pyruvate
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
is: HMDB00707
is: CHEBI:36242

metaR NDPK10n
is version of: http://identifiers.org/ec-code/2.7.4.6
is: SBO:0000176
modifier: MODEL1310110001#
name: nucleoside-diphosphate kinase (ATP:dIDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions. . Presence in the nucleus
reactant: MODEL1310110001#
type: Reaction
reversible: true
fast: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000304

metaR r0365
is version of: http://identifiers.org/ec-code/1.3.1.72
reactant: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Propanoate metabolism EC Number: 1.1.1.59 Confidence Level: 0 AUTHORS: PMID:13672942 NOTES:
fast: false
is: SBO:0000176
name: 3-hydroxypropanoate:NAD+ oxidoreductase beta-Alanine metabolism / Propanoate metabolism EC:1.1.1.59
kinetic law: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_7e01b158_7023_4ba0_8c85_70521f5fae91
is: Q8WZ48
name: CPT1A
has only substance units: false
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:1374
is: SBO:0000252

metaM tre e
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: C01083
name: Trehalose
has only substance units: false
constant: false
is: HMDB00975
is: CHEBI:16551
initial amount: NaN
notes: FORMULA: C12H22O11 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00658 EHMN_ABBREVIATION: C01083
type: Species

metaR TXA2tr
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism for transport - known to be secreted from cells - unknown mechanism or pathway, TXA2tr -> TXA2te to get to EC space NJ
reversible: true
is described by: ECO:0000000
product: MODEL1310110001#
name: thromboxane A2 intracellular transport
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#

metaR RE2626C
reactant: MODEL1310110001#
reversible: true
fast: false
is described by: ECO:0000000
is: SBO:0000176
type: Reaction
name: RE2626
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
kinetic law: MODEL1310110001#
product: MODEL1310110001#

metaR r2532
is described by: ECO:0000000
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reactant: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
product: MODEL1310110001#

metaM pre prot r
is: HMDB03125
is: SBO:0000247
type: Species
name: glycophosphatidylinositol (GPI)-anchored protein precursor
initial amount: NaN
notes: FORMULA: XY CHARGE: 0
is: CHEBI:16240
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_9774da74_c54f_4545_a91d_0b0909cbaa5d
is encoded by: hsa:5287
has only substance units: false
constant: false
type: Species
boundary condition: true
is: SBO:0000252
name: PIK3C2B
initial amount: NaN
is: O00750
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_89309bba_431e_427c_a8eb_4f3260c71cb1
is encoded by: hsa:3251
has only substance units: false
initial amount: NaN
is: P00492
constant: false
name: HPRT1
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species

metaM lanost r
is: SBO:0000247
is: CHEBI:16521
initial concentration: 1.0
constant: false
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00833 EHMN_ABBREVIATION: C01724
is: HMDB01251
boundary condition: false
name: lanosterol
type: Species
initial amount: NaN
has only substance units: false

metaM m8mpdol U r
is: SBO:0000247
is: CHEBI:59093
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
notes: FORMULA: C1725H2840N20O620P20 CHARGE: -20 INCHI: InChI=1S/C95H162N2O62P2/c1-34(2)13-9-14-35(3)15-10-16-36(4)17-11-18-37(5)19-12-20-38(6)21-22-138-160(132,133)159-161(134,135)158-86-53(97-40(8)108)64(119)77(49(31-106)147-86)150-85-52(96-39(7)107)63(118)78(48(30-105)146-85)151-91-76(131)80(153-94-84(71(126)60(115)46(28-103)144-94)157-95-83(70(125)59(114)47(29-104)145-95)156-90-74(129)67(122)56(111)43(25-100)141-90)62(117)51(149-91)32-136-87-75(130)79(152-93-82(69(124)58(113)45(27-102)143-93)155-89-73(128)66(121)55(110)42(24-99)140-89)61(116)50(148-87)33-137-92-81(68(123)57(112)44(26-101)142-92)154-88-72(127)65(120)54(109)41(23-98)139-88/h13,15,17,19,38,41-95,98-106,109-131H,9-12,14,16,18,20-33H2,1-8H3,(H,96,107)(H,97,108)(H,132,133)(H,134,135)/b35-15+,36-17+,37-19+/t38?,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66+,67+,68+,69+,70+,71+,72+,73+,74+,75+,76+,77-,78-,79+,80+,81+,82+,83+,84+,85+,86-,87+,88-,89-,90-,91+,92+,93-,94-,95-/m1/s1
has only substance units: false

metaM stcoa c
initial concentration: 1.0
name: Stearoyl-CoA (n-C18:0CoA)
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
is: C00412
notes: FORMULA: C39H66N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00338 EHMN_ABBREVIATION: C00412
is: SBO:0000247
is: HMDB01114
is: CHEBI:57394
constant: false

metaR MACACI
notes: GENE_ASSOCIATION: (2954.1) or (2954.3) or (2954.2) SUBSYSTEM: Tyrosine metabolism EC Number: 5.2.1.2 Confidence Level: 4 AUTHORS: PMID:10373324 NOTES:NCD
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
reversible: false
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/2.5.1.18
name: maleylacetoacetate isomerase

http://identifiers.org/biomodels.db/MODEL1310110001#_39c4951a_125b_4c2d_a60e_2ce8f89263ea
name: _FLJ44968_1_m
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:FLJ44968
type: Species

metaM datp c
name: dATP
notes: FORMULA: C10H12N5O12P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00129 EHMN_ABBREVIATION: C00131
type: Species
is: CHEBI:61404
boundary condition: false
is: HMDB01532
is: C00131
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0

metaM dhbpt c
initial concentration: 1.0
type: Species
notes: FORMULA: C9H13N5O3 CHARGE: 0 INCHI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,15-16H,2H2,1H3,(H3,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00242 EHMN_ABBREVIATION: C00268
is: SBO:0000247
boundary condition: false
is: CHEBI:20680
constant: false
is: HMDB00038
initial amount: NaN
name: 6,7-dihydrobiopterin
has only substance units: false

metaR GLYPHEPEPT1tc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of Glycylphenylalanine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine and renal cells
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_61b44ee3_add2_4b03_bfeb_426d2ddf9a7c
type: Species
is encoded by: hsa:2936
initial amount: NaN
is: P00390
name: GSR
boundary condition: true
has only substance units: false
initial concentration: NaN
constant: false
is: SBO:0000252

metaM docohepcoa m
initial amount: NaN
constant: false
is: http://identifiers.org/pubchem.compound/24892790
initial concentration: 1.0
has only substance units: false
type: Species
notes: FORMULA: C43H60N7O17P3S CHARGE: -4
is: SBO:0000247
name: 2,4,7,10,13,16,19-docosaheptenoylcoa
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_ef607017_3df5_4711_b6f7_0ad786032dae
has only substance units: false
constant: false
is encoded by: hsa:257202
initial concentration: NaN
initial amount: NaN
type: Species
name: GPX6
is: P59796
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_81acfce3_e7dc_4a93_b56d_47656b748caf
name: PDE8A
type: Species
is: H0YMZ7
initial amount: NaN
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5151
initial concentration: NaN
has only substance units: false
constant: false

metaR r2535
type: Reaction
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
product: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.44.1

metaM ksi pre23 g
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 23
is: CHEBI:28067
initial concentration: 1.0
has only substance units: false
boundary condition: false
notes: FORMULA: C185H296N13O153S7X CHARGE: -8
type: Species
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_575a406c_2ff5_4fc0_ac19_974f0bfe8dc2
is: SBO:0000252
is encoded by: hsa:492
initial concentration: NaN
boundary condition: true
constant: false
name: ATP2B3
has only substance units: false
initial amount: NaN
is: Q16720
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_e9f77c39_ee35_445b_87c3_0ab5b6b842ff
is encoded by: hsa:51
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: ACOX1
is: B4DK61
initial amount: NaN
boundary condition: true
has only substance units: false

metaR DNDPt26m
reversible: false
modifier: MODEL1310110001#
is described by: ECO:0000269
reactant: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
name: dCDP transport via dUDP antiport

http://identifiers.org/biomodels.db/MODEL1310110001#_75f34d9c_1319_4858_bcf1_1caae62370e4
type: Species
has only substance units: false
is encoded by: hsa:27068
boundary condition: true
name: PPA2
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: F8WDN9
constant: false

metaR RE0453N
product: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4830.1) or (4831.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
reversible: true
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
fast: false
modifier: MODEL1310110001#
name: RE0453
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_97291be5_2a29_4052_b4e8_439fe8108ef6
type: Species
is encoded by: hsa:22305
name: _22305_2_c
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252

metaR r1864
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110001#
name: Y+LAT2 Utilized transport
product: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110001#_81a5d1ed_fb7b_4421_a07b_cbcbe079ef48
name: SOAT2
initial amount: NaN
type: Species
is: O75908
has only substance units: false
is encoded by: hsa:8435
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM acgal1p c
type: Species
constant: false
notes: FORMULA: C8H14NO9P CHARGE: -2 INCHI: InChI=1S/C8H16NO9P/c1-3(11)9-5-7(13)6(12)4(2-10)17-8(5)18-19(14,15)16/h4-8,10,12-13H,2H2,1H3,(H,9,11)(H2,14,15,16)/t4-,5-,6+,7-,8?/m1/s1
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:55404
initial concentration: 1.0
is: HMDB06480
name: N-Acetyl-D-galactosamine 1-phosphate

metaR 3HLYTCL
modifier: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (1644.1) SUBSYSTEM: Tyrosine metabolism EC Number: 4.1.1.28 Confidence Level: 4 AUTHORS: NOTES:SAB
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.1.1.28
name: 3-Hydroxy-L-tyrosine carboxy-lyase

http://identifiers.org/biomodels.db/MODEL1310110001#_fd8d6137_a571_4ec5_9555_2a92c11ef761
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:NM 013421
constant: false
type: Species
name: _NM_013421_1_m

metaR r2534
is described by: ECO:0000000
kinetic law: MODEL1310110001#
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
type: Reaction
product: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is: SBO:0000185

metaM 34dhmald m
has only substance units: false
is: HMDB06242
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C8H8O4 CHARGE: 0 INCHI: InChI=1/C8H8O4/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-4,8,10-12H HEPATONET_1.0_ABBREVIATION: HC01514 EHMN_ABBREVIATION: C05577
initial amount: NaN
name: 3,4-Dihydroxymandelaldehyde
is: C05577
type: Species
is: SBO:0000247
constant: false
is: http://identifiers.org/pubchem.compound/7903

metaR GLCAASE9ly
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Hyaluronan metabolism EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
is described by: ECO:0000269
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.31
type: Reaction
reversible: false
product: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
is: SBO:0000176
name: beta-glucuronidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110001#_70df0451_9bcf_4b24_9dd6_472ec034dd39
constant: false
is encoded by: hsa:27235
is: SBO:0000252
is: Q96H96
name: COQ2
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
has only substance units: false

metaM estrone c
constant: false
notes: FORMULA: C18H22O2 CHARGE: 0 INCHI: InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1 EHMN_ABBREVIATION: C00468
boundary condition: false
name: estrone
has only substance units: false
is: CHEBI:17263
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB00145
is: SBO:0000247

metaR RE0453M
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
modifier: MODEL1310110001#
reactant: MODEL1310110001#
name: RE0453
is: SBO:0000176
kinetic law: MODEL1310110001#
type: Reaction
fast: false
reversible: true
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.6

metaM cs b l
is: HMDB02183
type: Species
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S), free chain
initial amount: NaN
constant: false
notes: FORMULA: C45H66N2O49S4 CHARGE: -6
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: CHEBI:36005
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_c3d6dd08_db3d_4012_9957_3557d5a7e7f3
is encoded by: hsa:9154
type: Species
has only substance units: false
initial amount: NaN
is: O00337
name: SLC28A1
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false

metaR DHPM2
kinetic law: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 2 AUTHORS: NOTES:Also acts on dihydrothymine and hydantoin. Found not specific evidence in PubMed, but Dihydropyrimidinase is supposed to be in cytosol and catalyze this reaction. Old information
name: dihydropyrimidinase (dihydrothymine)
product: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000000
fast: false
reversible: false

metaR SUCCCROT
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of succinyl carnitine
type: Reaction

metaM HC01602 c
name: 10-Formyltetrahydrofolate
type: Species
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C20H21N7O7 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00212 EHMN_ABBREVIATION: C00234
constant: false
is: C00234
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:57454

http://identifiers.org/biomodels.db/MODEL1310110001#_7be23f18_83eb_4095_94fc_5ba13559235a
is: SBO:0000252
type: Species
is encoded by: hsa:51227
has only substance units: false
constant: false
initial amount: NaN
name: PIGP
initial concentration: NaN
boundary condition: true

metaM tdchola e
initial concentration: 1.0
name: taurochenodeoxycholate
initial amount: NaN
is: HMDB00951
boundary condition: false
constant: false
type: Species
notes: FORMULA: C26H45NO6S CHARGE: 0 INCHI: InChI=1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/p-1/t16-,17+,18-,19-,20+,21+,22-,24+,25+,26-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01471 EHMN_ABBREVIATION: C05465
has only substance units: false
is: CHEBI:9407
is: SBO:0000247

metaR r2537
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
reversible: true
fast: false
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
name: Utilized transport
is: SBO:0000185

metaM hdcea c
initial concentration: 1.0
initial amount: NaN
type: Species
name: Hexadecenoate (n-C16:1)
constant: false
notes: FORMULA: C16H29O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
has only substance units: false
is: SBO:0000247
is: CHEBI:32372
boundary condition: false
is: HMDB03229

metaR FAOXC226205m
product: MODEL1310110001#
reversible: false
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000000
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (35.1) or (34.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: PMID:2565344,PMID:3035565 NOTES:_1 round of beta-oxidation, loses degree of desat, so no fad peroxisomal (very long chain FA) c22:6,n-3 -> c20:5, n-3 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/1.3.99.3
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR FAOXC6C4x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C6-->C4)x
type: Reaction

metaR r1538
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110001#
name: Anion Exchanger (AE) TCDB:2.A.31.2.8
fast: false
notes: GENE_ASSOCIATION: (BE966236.1) or (6240.1) or (6241.1) or (50484.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14722772 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.17.4.1
reversible: false
product: MODEL1310110001#
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#

metaM dtdp c
initial concentration: 1.0
is: C00363
is: SBO:0000247
is: HMDB01274
is: CHEBI:58369
initial amount: NaN
name: dTDP
has only substance units: false
notes: FORMULA: C10H13N2O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00307 EHMN_ABBREVIATION: C00363
boundary condition: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_967c1604_53ef_462e_b37c_6262a6c4944f
type: Species
constant: false
has only substance units: false
is encoded by: hsa:6470
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: SHMT1
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_5ca580d7_9a79_4cd2_9b88_1085c2f449d8
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6476
initial concentration: NaN
is: P14410
type: Species
name: SI

metaR DHPM1
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.5.2.2
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.2.2 Confidence Level: 4 AUTHORS: PMID:8973361 NOTES:
is described by: ECO:0000269
is: SBO:0000176
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#
name: dihydropyrimidinase (5,6-dihydrouracil)

metaR PEAMNO
name: Phenethylamine oxidase
type: Reaction
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/1.4.3.4
reversible: false
notes: GENE_ASSOCIATION: (314.1) or (4128.1) or (26.1) or (4129.1) or (314.2) SUBSYSTEM: Phenylalanine metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:10389141,PMID:15035803,PMID:8920635,PMID:9653080 NOTES:JLR- Kegg reaction R02613
fast: false
is: SBO:0000176
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.4.3.22
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.4.3.21
reactant: MODEL1310110001#

metaR LALDO
name: D-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)
reversible: true
is: SBO:0000176
reactant: MODEL1310110001#
product: MODEL1310110001#
fast: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.1.1.1
type: Reaction
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (128.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.1 Confidence Level: 0 AUTHORS: NOTES:EC 1.2.1.1 NCD
modifier: MODEL1310110001#

metaM HC01842 c
type: Species
constant: false
is: CHEBI:31997
boundary condition: false
initial amount: NaN
has only substance units: false
initial concentration: 1.0
name: Phosphodimethylethanolamine
is: SBO:0000247
notes: FORMULA: C4H10NO4P CHARGE: -2 INCHI: InChI=1S/C4H12NO4P/c1-5(2)3-4-9-10(6,7)8/h3-4H2,1-2H3,(H2,6,7,8)

http://identifiers.org/biomodels.db/MODEL1310110001#_587d9430_66ca_4a58_a1c7_fbd2a36e12a7
has part: P33402
initial concentration: NaN
has part: Q02153
name: GUCY1A2:GUCY1B3
has only substance units: false
constant: false
boundary condition: true
is encoded by: hsa:2983
is: SBO:0000297
is encoded by: hsa:2977
initial amount: NaN
type: Species

metaR DIDPtn
type: Reaction
reversible: true
is described by: ECO:0000000
fast: false
is: SBO:0000185
product: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
kinetic law: MODEL1310110001#
name: dIDP nuclear transport

metaM ksi pre1 g
constant: false
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 1
is: C00130
boundary condition: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58053
is: HMDB00175
notes: FORMULA: C79H129N5O57X CHARGE: -1
type: Species

metaM m2mpdol U c
initial concentration: 1.0
initial amount: NaN
constant: false
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
notes: FORMULA: C1365H2240N20O320P20 CHARGE: -20
is: SBO:0000247
has only substance units: false
is: CHEBI:28049
boundary condition: false

metaR STS2
kinetic law: MODEL1310110001#
fast: false
product: MODEL1310110001#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.2
name: Steryl-sulfatase
modifier: MODEL1310110001#
reversible: false
is described by: ECO:0000269
reactant: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ

metaR FCLTm
type: Reaction
reversible: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000176
name: Ferrochelatase, mitochondrial
fast: false
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.99.1.1
notes: GENE_ASSOCIATION: (2235.1) or (2235.2) SUBSYSTEM: Heme synthesis EC Number: 4.99.1.1 Confidence Level: 2 AUTHORS: PMID:7983009 NOTES:NCD; r0096
is described by: ECO:0000304

metaR O2Stx
kinetic law: MODEL1310110001#
type: Reaction
name: superoxide anion transport via diffusion (peroxisome)
reactant: MODEL1310110001#
is: SBO:0000185
reversible: true
fast: false
product: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:

metaR GMPtn
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
type: Reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: GMP nuclear transport
reversible: true
reactant: MODEL1310110001#
is: SBO:0000185
fast: false
is described by: ECO:0000000

metaR ARACHDt2
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
name: fatty acid transport via diffusion
type: Reaction
reactant: MODEL1310110001#
fast: false
reversible: true

metaM 34hpp c
boundary condition: false
initial amount: NaN
name: 3-(4-hydroxyphenyl)pyruvate
initial concentration: 1.0
has only substance units: false
is: CHEBI:36242
is: SBO:0000247
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1 HEPATONET_1.0_ABBREVIATION: HC00699 EHMN_ABBREVIATION: C01179
is: HMDB00707
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_c33b461d_e372_4480_adde_b98cc24fa786
initial amount: NaN
is: Q9H903
initial concentration: NaN
is: SBO:0000252
has only substance units: false
type: Species
constant: false
boundary condition: true
name: MTHFD2L
is encoded by: hsa:441024

metaR RE0958E
is version of: http://identifiers.org/ec-code/3.2.1.17
reactant: MODEL1310110001#
fast: false
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.2.1.1
name: RE0958
product: MODEL1310110001#
is described by: ECO:0000000
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) or (280.1) or (84569.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:8528071,PMID:890964 NOTES:
reversible: true
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_3c3bd126_61f5_4d9e_9650_636b6af8837a
initial concentration: NaN
is: Q9BT22
type: Species
is encoded by: hsa:56052
name: ALG1
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false

metaR RE0690E
is version of: http://identifiers.org/ec-code/1.4.3.22
type: Reaction
reversible: false
is described by: ECO:0000000
name: RE0690
is: SBO:0000176
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
product: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#

metaM tym c
type: Species
is: CHEBI:327995
constant: false
boundary condition: false
is: HMDB00306
notes: FORMULA: C8H12NO CHARGE: 1 INCHI: InChI=1S/C8H11NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5-6,9H2/p+1 EHMN_ABBREVIATION: C00483
has only substance units: false
name: tyraminium
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaR AKR1D2
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reactant: MODEL1310110001#
type: Reaction
is described by: ECO:0000269
reversible: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/1.3.1.3
notes: GENE_ASSOCIATION: (6718.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.99.6 Confidence Level: 4 AUTHORS: NOTES:refs: uniprot, KEGG DW Russell bile acid synthesis review paper (see human recon journal citations) NJ

metaR r2005
modifier: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false
product: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
is described by: ECO:0000000
fast: false

metaM ksi deg3 l
is: SBO:0000247
type: Species
has only substance units: false
is: HMDB00573
initial concentration: 1.0
constant: false
initial amount: NaN
name: keratan sulfate I, degradation product 3
is: CHEBI:30825
notes: FORMULA: C233H371N16O205S12 CHARGE: -13
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_d22ba5bb_ab3f_471f_9248_8e3a83221240
has only substance units: false
constant: false
initial amount: NaN
type: Species
boundary condition: true
is: Q96BD0
is encoded by: hsa:28231
is: SBO:0000252
name: SLCO4A1
initial concentration: NaN

metaR EX 7thf LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptaglutamyl folate (THF) exchange
type: Reaction

metaM cspg a l
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
boundary condition: false
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
constant: false
is: CHEBI:36005
has only substance units: false
notes: FORMULA: C45H66N2O45S3X CHARGE: -5
is: HMDB02183

metaR EX 5oxpro LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 5-oxoprolinate
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_02f4a47f_4df5_487a_9cea_89ef0008a736
is encoded by: hsa:4716
initial amount: NaN
type: Species
has only substance units: false
is: SBO:0000252
is: A8K761
boundary condition: true
initial concentration: NaN
name: NDUFB10
constant: false

metaM 4hglusa m
is: HMDB06556
has only substance units: false
type: Species
initial amount: NaN
boundary condition: false
name: L-4-hydroxyglutamic semialdehyde
constant: false
is: CHEBI:27809
notes: FORMULA: C5H9NO4 CHARGE: 0 INCHI: InChI=1S/C5H9NO4/c6-4(5(9)10)1-3(8)2-7/h2-4,8H,1,6H2,(H,9,10)/t3-,4+/m1/s1 EHMN_ABBREVIATION: C05938
is: SBO:0000247
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_2de077c3_ad11_40cb_937e_11cf038dcd4c
is: E7EQF2
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:54677
constant: false
initial amount: NaN
initial concentration: NaN
name: CROT

http://identifiers.org/biomodels.db/MODEL1310110001#_3d292c37_e44f_4c8f_aefd_1ec9102b04d9
constant: false
boundary condition: true
name: PDE9A
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:5152
has only substance units: false
initial concentration: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_0def8590_699e_4a3b_a3c1_189d624acbfe
initial amount: NaN
is: P61457
constant: false
initial concentration: NaN
is encoded by: hsa:5092
type: Species
name: PCBD1
has only substance units: false
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_9fc6535d_9aec_483a_96c1_7a749b52fd06
constant: false
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:83884
is: SBO:0000252
name: SLC25A2
type: Species
initial amount: NaN
is: Q9BXI2

http://identifiers.org/biomodels.db/MODEL1310110001#_fcb5e664_e876_4e5e_b8c0_0762f7c3611d
is encoded by: hsa:284098
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
is: Q7Z7B1
constant: false
has only substance units: false
boundary condition: true
name: PIGW

metaM 34hpp e
boundary condition: false
name: 3-(4-hydroxyphenyl)pyruvate
is: SBO:0000247
is: HMDB00707
initial concentration: 1.0
is: CHEBI:36242
constant: false
notes: FORMULA: C9H7O4 CHARGE: -1 INCHI: InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)/p-1
has only substance units: false
type: Species
initial amount: NaN

metaR SPH1Pte
name: sph1p transport
fast: false
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15585321 NOTES:unknown mechanism for transport, may be vesicular/caveolar/other ... intracellular transport and extracellular export mechanisms must exist - see for example: PMID: 15585321 NJ
is: SBO:0000185
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_39dcd6b7_56b2_427f_9216_57e84e9a9268
initial amount: NaN
is encoded by: hsa:5148
has only substance units: false
has part: O43924
is: SBO:0000297
name: PDE6A:PDE6C:PDE6D:PDE6G:PDE6B
constant: false
initial concentration: NaN
has part: P18545
is encoded by: hsa:5147
type: Species
boundary condition: true

metaM ksi deg39 l
is: HMDB00143
constant: false
is: CHEBI:12936
initial concentration: 1.0
initial amount: NaN
name: keratan sulfate I, degradation product 39
notes: FORMULA: C48H81N3O36 CHARGE: 0
boundary condition: false
is: SBO:0000247
type: Species
has only substance units: false

metaR PGLer
is: SBO:0000176
type: Reaction
reactant: MODEL1310110001#
is described by: ECO:0000269
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.47
name: 6-phosphogluconolactonase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 3.1.1.31 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:SMP Net reaction same as described in Lehringer 334 NCD
reversible: false
modifier: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#

metaM ksii core2 pre2 g
is: HMDB00175
initial amount: NaN
constant: false
has only substance units: false
is: C00130
type: Species
initial concentration: 1.0
is: CHEBI:58053
name: keratan sulfate II biosynthesis, precursor 2
notes: FORMULA: C39H63N3O28X CHARGE: -1
boundary condition: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_f8fde851_02ff_4d1b_b602_287246f10232
has only substance units: false
constant: false
boundary condition: true
is: SBO:0000252
is encoded by: hsa:5136
initial amount: NaN
is: P54750
name: PDE1A
initial concentration: NaN
type: Species

metaR STS1
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 4 AUTHORS: PMID:2668275,PMID:6957717 NOTES:NJ
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.2
modifier: MODEL1310110001#
name: Steryl-sulfatase
type: Reaction
is described by: ECO:0000269

metaR MALtm
type: Reaction
product: MODEL1310110001#
name: malate transport, mitochondrial
reversible: true
fast: false
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:IF
is described by: ECO:0000269
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110001#_a1575bad_d028_447d_ab70_257870187966
is encoded by: hsa:57468
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
is: Q9H2X9
boundary condition: true
name: SLC12A5

metaR S6TASE11ly
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.6.14
is: SBO:0000176
type: Reaction
fast: false
name: N-acetylglucosamine-6-sulfatase, lysosomal
reactant: MODEL1310110001#
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_930e59bd_5816_44bf_869f_09525fc7223e
type: Species
has only substance units: false
name: UAP1
is: Q16222
initial concentration: NaN
is encoded by: hsa:6675
is: SBO:0000252
initial amount: NaN
constant: false
boundary condition: true

metaM pd3 c
boundary condition: false
initial amount: NaN
type: Species
has only substance units: false
initial concentration: 1.0
name: Previtamin D3
is: HMDB06500
is: SBO:0000247
constant: false
notes: FORMULA: C27H44O CHARGE: 0 INCHI: InChI=1/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h10,12-13,19,21,24-26,28H,6-9,11,14-18H2,1-5H3/b13-12-/t21-,24+,25-,26?,27-/m1/s1

metaR AG13T8g
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
modifier: MODEL1310110001#
reversible: false
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
product: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.149

http://identifiers.org/biomodels.db/MODEL1310110001#_230330c5_8db1_4011_9546_87331dfda2e6
type: Species
name: SLC35D2
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
is encoded by: hsa:11046
constant: false
is: Q76EJ3

metaR r2007
modifier: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
fast: false
is described by: ECO:0000000
product: MODEL1310110001#
reversible: false
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR EX strch2 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_8f5eec4e_1480_4d5e_a06f_844be32de82f
has only substance units: false
name: SDHC
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
is: Q99643
type: Species
boundary condition: true
is encoded by: hsa:6391
constant: false

metaR THFtm
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:11375437 NOTES:NCD
type: Reaction
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110001#
fast: false
reversible: true

metaR GCHOLAt2
name: glycocholate transport via sodium cotransport
product: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000185
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (6554.1) or (6555.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12851823,PMID:7592981,PMID:8132774,PMID:9109432 NOTES:electrogenic uptake NJ
reversible: false
fast: false
type: Reaction
kinetic law: MODEL1310110001#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110001#_ce68b6e7_9555_42b7_9ccd_e4b48122db4e
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
name: ATP5H
constant: false
is encoded by: hsa:10476
boundary condition: true
type: Species
is: O75947

metaR RE2626M
reversible: true
name: RE2626
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Bile acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:9210654,PMID:9660774 NOTES:
is: SBO:0000176
fast: false
modifier: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110001#

metaM trp L c
initial amount: NaN
initial concentration: 1.0
is: HMDB00929
constant: false
name: L-tryptophan
type: Species
boundary condition: false
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: CHEBI:16828
is: SBO:0000247
has only substance units: false

metaR r0009
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
name: Pyrophosphate phosphohydrolase EC:3.6.1.1
reversible: false
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.6.1.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (AI990637.1) or (64077.1) or (5464.1) or (27068.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.1 Confidence Level: 0 AUTHORS: PMID:10542310,PMID:16300924 NOTES:IT - fixed proton
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_e6fb8f37_ee67_4231_b2e3_030fb2af7f21
type: Species
is encoded by: hsa:55577
is: Q9UJ70
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: NAGK
constant: false

metaR r1109
type: Reaction
is: SBO:0000176
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 4.1.3.6 Confidence Level: 0 AUTHORS: PMID:11741334 NOTES:
reversible: true
product: MODEL1310110001#
name: Citrate oxaloacetate-lyase ((pro-3S)-CH2COO- -->acetate) Citrate cycle (TCA cycle) EC:4.1.3.6
fast: false
is described by: ECO:0000000

metaM andrstandn r
is: HMDB00899
type: Species
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C00674
boundary condition: false
is: CHEBI:15994
initial amount: NaN
has only substance units: false
name: 5alpha-androstane-3,17-dione
constant: false
initial concentration: 1.0
is: SBO:0000247

metaM dheas c
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
name: 3beta-hydroxyandrost-5-en-17-one 3-sulfate(1-)
initial amount: NaN
is: CHEBI:57905
notes: FORMULA: C19H27O5S CHARGE: -1 INCHI: InChI=1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/p-1/t13-,14-,15-,16-,18-,19-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01314 EHMN_ABBREVIATION: C04555
constant: false
is: HMDB01032
type: Species

metaR EX glygn2 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]}) exchange
type: Reaction

metaM ocdececrn c
has only substance units: false
initial concentration: 1.0
type: Species
is: HMDB06351
name: 11-octadecenoyl carnitine
notes: FORMULA: C25H47NO4 CHARGE: 0
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_46bf4a61_c75f_4cd3_aa52_0e5c794240a0
has only substance units: false
name: ETFB
is: P38117
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:2109

http://identifiers.org/biomodels.db/MODEL1310110001#_c4529c6b_d029_4ead_865e_a9825f17d66c
constant: false
initial concentration: NaN
boundary condition: true
has only substance units: false
is encoded by: hsa:8854
name: ALDH1A2
type: Species
is: B4DZR2
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_77bae682_6946_4b6e_a295_17792014f931
is: P33261
is encoded by: hsa:1557
name: CYP2C19
type: Species
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_08e7e698_b4eb_4515_94a3_746aca69832d
initial amount: NaN
constant: false
type: Species
is: Q9Y6T7
initial concentration: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false
is encoded by: hsa:1607
name: DGKB

metaR DOLDPP Uer
reactant: MODEL1310110001#
name: Dolichyl-diphosphate phosphohydrolase, human (uterus)
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.6.1.43
reversible: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (57171.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.6.1.43 Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:NCD

metaR RE3270C
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:7556092 NOTES:IT - fixed proton
fast: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
is: SBO:0000176
name: RE3270

http://identifiers.org/biomodels.db/MODEL1310110001#_61a3a21a_ebc3_4acb_9c0c_77bc898c2ae4
has only substance units: false
initial concentration: NaN
constant: false
initial amount: NaN
is: SBO:0000252
type: Species
name: PDE9A
is encoded by: hsa:5152
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_d8cda557_5948_4d14_9fc8_451104bdc358
constant: false
initial amount: NaN
is: P17174
is encoded by: hsa:2805
has only substance units: false
boundary condition: true
name: GOT1
is: SBO:0000252
initial concentration: NaN
type: Species

metaR r0475
is described by: ECO:0000000
product: MODEL1310110001#
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
is: SBO:0000176
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
type: Reaction
kinetic law: MODEL1310110001#

metaM orot c
is: CHEBI:30839
initial concentration: 1.0
is: C00295
type: Species
boundary condition: false
has only substance units: false
is: HMDB00226
name: Orotate
constant: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_05472650_fa44_4f72_86b5_7b94a20ae082
initial amount: NaN
has only substance units: false
constant: false
name: IDH1
boundary condition: true
is: O75874
initial concentration: NaN
type: Species
is encoded by: hsa:3417
is: SBO:0000252

metaM k c
initial amount: NaN
name: potassium
has only substance units: false
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
is: SBO:0000247
is: CHEBI:29103
initial concentration: 1.0
is: C00238
type: Species
constant: false
is: HMDB00586
boundary condition: false

metaM oretn c
is: CHEBI:35291
has only substance units: false
constant: false
type: Species
name: 4-oxo-retinoic acid
boundary condition: false
is: SBO:0000247
is: HMDB01852
notes: FORMULA: C20H27O3 CHARGE: -1 INCHI: InChI=1/C20H26O3/c1-14(7-6-8-15(2)13-19(22)23)9-10-17-16(3)18(21)11-12-20(17,4)5/h6-10,13H,11-12H2,1-5H3,(H,22,23)/p-1
initial concentration: 1.0
initial amount: NaN

metaM 25aics c
notes: FORMULA: C13H15N4O12P CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01356 EHMN_ABBREVIATION: C04823
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
initial concentration: 1.0
is: C04823
is: SBO:0000247
initial amount: NaN
is: CHEBI:58443
constant: false
boundary condition: false
has only substance units: false
is: HMDB00797
type: Species

metaR PItx
is: SBO:0000185
kinetic law: MODEL1310110001#
fast: false
name: Phosphate transporter, peroxisome
reversible: true
type: Reaction
product: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
is described by: ECO:0000000

metaR r1252
reactant: MODEL1310110001#
name: EC:6.2.1.3
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 0 AUTHORS: PMID:8584017 NOTES:
reversible: false
fast: false
product: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_69084e1d_6d35_4c14_bd98_ea5c6c97b6e3
is: SBO:0000252
constant: false
has only substance units: false
initial concentration: NaN
name: COX4I1
type: Species
boundary condition: true
is: P13073
is encoded by: hsa:1327
initial amount: NaN

metaR r0474
kinetic law: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.4.1 Confidence Level: 0 AUTHORS: PMID:6121703,PMID:8074691 NOTES:
reversible: true
reactant: MODEL1310110001#
fast: false
name: 2-Deoxyadenosine 5-diphosphate:oxidized-thioredoxin 2-oxidoreductase Purine metabolism EC:1.17.4.1
type: Reaction
is described by: ECO:0000000

metaM trp L e
is: HMDB00929
initial concentration: 1.0
has only substance units: false
type: Species
name: L-tryptophan
boundary condition: false
is: SBO:0000247
notes: FORMULA: C11H12N2O2 CHARGE: 0 INCHI: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00080
is: CHEBI:16828
initial amount: NaN
constant: false

metaR r0156
kinetic law: MODEL1310110001#
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
type: Reaction
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (H77542.1) or (5313.1) or (5315.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
reversible: false
modifier: MODEL1310110001#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.1.40
is: SBO:0000176

metaR HDCAtr
kinetic law: MODEL1310110001#
name: fatty acid transport via diffusion
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
reversible: true
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000

metaR S6TASE22ly
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.6.4
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.4.16.5
fast: false
reversible: true
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD

metaR r0157
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (AA502753.1) or (1503.1) or (56474.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.15 Confidence Level: 0 AUTHORS: PMID:12850267,PMID:1296212,PMID:3003500,PMID:4762917,PMID:4797019,PMID:4822504,PMID:5059882 NOTES:
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/6.3.4.2
is: SBO:0000176
reversible: false
name: L-Glutamine:pyruvate aminotransferase Glutamate metabolism EC:2.6.1.15
type: Reaction

metaR r0360
is version of: http://identifiers.org/ec-code/6.2.1.16
name: Glycolysis / Glyconeogenesis EC:2.7.1.1
product: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (65985.1) or (R39999.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.1 Confidence Level: 0 AUTHORS: PMID:16906315,PMID:7061426,PMID:7150652,PMID:8717435 NOTES:
kinetic law: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#
reactant: MODEL1310110001#

metaR GCHOLAt3
kinetic law: MODEL1310110001#
is described by: ECO:0000269
name: ABC bile acid transporter
modifier: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (8714.3) or (8647.1) or (8714.2) or (8714.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9738950,PMID:9806540,PMID:9813153 NOTES:for bile acid secretion into bile NJ
product: MODEL1310110001#
is: SBO:0000185
reactant: MODEL1310110001#
reversible: false
fast: false

metaM k e
is: SBO:0000247
name: potassium
is: C00238
is: CHEBI:29103
constant: false
has only substance units: false
initial concentration: 1.0
notes: FORMULA: K CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00216 EHMN_ABBREVIATION: C00238
type: Species
is: HMDB00586
initial amount: NaN
boundary condition: false

metaM occoa m
notes: FORMULA: C29H46N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00869 EHMN_ABBREVIATION: C01944
constant: false
type: Species
initial concentration: 1.0
name: Octanoyl-CoA (n-C8:0CoA)
boundary condition: false
is: HMDB01070
is: C01944
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:57386

metaM orot e
type: Species
initial concentration: 1.0
is: HMDB00226
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C5H3N2O4 CHARGE: -1 INCHI: InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11)/p-1 HEPATONET_1.0_ABBREVIATION: HC00256 EHMN_ABBREVIATION: C00295
initial amount: NaN
is: SBO:0000247
name: orotate
is: CHEBI:30839

metaR RE0453C
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
name: RE0453
is described by: ECO:0000000
reversible: true
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine synthesis EC Number: 2.7.4.6 Confidence Level: 0 AUTHORS: PMID:3026468 NOTES:
fast: false

metaM itaccoa m
name: itaconyl-CoA(5-)
has only substance units: false
constant: false
boundary condition: false
type: Species
is: CHEBI:57381
notes: FORMULA: C26H35N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H40N7O19P3S/c1-13(25(39)40)8-16(35)56-7-6-28-15(34)4-5-29-23(38)20(37)26(2,3)10-49-55(46,47)52-54(44,45)48-9-14-19(51-53(41,42)43)18(36)24(50-14)33-12-32-17-21(27)30-11-31-22(17)33/h11-12,14,18-20,24,36-37H,1,4-10H2,2-3H3,(H,28,34)(H,29,38)(H,39,40)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,18-,19-,20+,24-/m1/s1 EHMN_ABBREVIATION: C00531
initial amount: NaN
initial concentration: 1.0
is: HMDB03377
is: SBO:0000247

metaM glyc S c
is: HMDB06372
has only substance units: false
is: SBO:0000247
type: Species
name: (S)-Glycerate
initial concentration: 1.0
initial amount: NaN
is: CHEBI:33871
boundary condition: false
notes: FORMULA: C3H5O4 CHARGE: 0
constant: false

metaR IZPN
reversible: false
type: Reaction
is: SBO:0000176
is described by: ECO:0000000
name: Imidazolonepropionase
reactant: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Histidine metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
fast: false

metaR r1106
fast: false
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
type: Reaction
is: SBO:0000185
name: Postulated transport reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_cc91ee5a_9346_4295_acf7_43d1f63a297d
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
name: AHCY
constant: false
is: B3KUN3
initial concentration: NaN
is encoded by: hsa:191

metaM man6p c
name: D-Mannose 6-phosphate
type: Species
boundary condition: false
is: CHEBI:17369
initial amount: NaN
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H11O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00246 EHMN_ABBREVIATION: C00275
constant: false
is: HMDB01078

metaR r1671
name: Y+LAT2 Utilized transport
product: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110001#
is: SBO:0000185
reversible: true
type: Reaction

metaM prostgd2 r
boundary condition: false
type: Species
constant: false
name: prostaglandin D2(1-)
is: HMDB01403
is: CHEBI:57406
initial concentration: 1.0
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false
is: SBO:0000247
initial amount: NaN

metaM o2s n
boundary condition: false
is: HMDB02168
constant: false
name: superoxide
initial amount: NaN
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:18421
type: Species
has only substance units: false

metaR 5AOPtm
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:10558864 NOTES:NCD. Delta-aminolevulinic acid is produced in mitochondria then converted to PBG in the cytoplasm. Could not find anything on the transporter itself.
reversible: true
is: SBO:0000185
reactant: MODEL1310110001#
is described by: ECO:0000134
product: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
name: 5-Aminolevulinate mitochondrial transport
fast: false

metaM 5adtststerone c
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
is: CHEBI:16330
is: HMDB02961
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
name: 17beta-hydroxy-5alpha-androstan-3-one

metaR FE2tm
name: iron (II) transport
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10383398,PMID:12755454 NOTES:TDV Lange H, 1999.
is: SBO:0000185
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110001#_69a7c29c_e254_4b3c_87ab_7aa7d26eebe5
type: Species
has only substance units: false
is encoded by: hsa:2645
name: GCK
constant: false
is: SBO:0000252
initial concentration: NaN
is: Q53Y25
boundary condition: true
initial amount: NaN

metaR LINKDEG1ly
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: Confidence Level: 2 AUTHORS: PMID:8993162 NOTES:NCD
is: SBO:0000176
product: MODEL1310110001#
reversible: false
type: Reaction
name: degradation of proteoglycan linkage region, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110001#_fe78c847_e2fb_4422_aa93_c63a3cc88dcf
initial concentration: NaN
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:10841
name: FTCD
type: Species
constant: false

metaM leuktrC4 c
initial amount: NaN
name: leukotriene C4(2-)
is: HMDB01198
is: SBO:0000247
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
constant: false
type: Species
has only substance units: false
is: CHEBI:57973
initial concentration: 1.0
boundary condition: false

metaR ASPGLUm
notes: GENE_ASSOCIATION: (8604.1) or (10165.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
fast: false
type: Reaction
kinetic law: MODEL1310110001#
name: aspartate-glutamate mitochondrial shuttle
reactant: MODEL1310110001#
reversible: true
modifier: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000269

metaR DOLPH Ler
is: SBO:0000176
kinetic law: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
fast: false
reactant: MODEL1310110001#
reversible: false
type: Reaction
is described by: ECO:0000000
name: Dolichol-phosphate phosphohydrolase, human (liver)

metaR CHAT
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (1103.4) or (1103.2) or (1103.3) or (1103.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.3.1.6 Confidence Level: 4 AUTHORS: PMID:10861222 NOTES:rev by uniprot NJ
reactant: MODEL1310110001#
name: Choline O-acetyltransferase
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.6
type: Reaction
fast: false

metaR DALAt2r
modifier: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
name: D-alanine transport via proton symport
is described by: ECO:0000304
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:JLR
reversible: true
is: SBO:0000185
fast: false

metaR r0196
product: MODEL1310110001#
name: Succinyl-CoA:glycine C-succinyl-transferase(decarboxylating) EC:2.3.1.37
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (AV717590.1) or (953.1) or (956.1) or (377841.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.37 Confidence Level: 0 AUTHORS: PMID:7592562 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.6.1.5
is: SBO:0000176
reversible: true
modifier: MODEL1310110001#

metaM ca2 e
initial concentration: 1.0
is: HMDB00464
type: Species
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
name: calcium(2+)
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:29108
boundary condition: false
initial amount: NaN

metaM ksi deg21 l
initial concentration: 1.0
notes: FORMULA: C132H213N9O114S6 CHARGE: -6
is: HMDB00143
boundary condition: false
is: SBO:0000247
type: Species
is: CHEBI:12936
constant: false
initial amount: NaN
has only substance units: false
name: keratan sulfate I, degradation product 21

http://identifiers.org/biomodels.db/MODEL1310110001#_5dc6558c_63aa_4529_8148_392a7c60fa53
has only substance units: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: P49888
constant: false
is encoded by: hsa:6783
name: SULT1E1
is: SBO:0000252
type: Species

metaM glygn5 e
is: SBO:0000247
is: CHEBI:33871
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C12H21O11X CHARGE: 0
initial amount: NaN
is: HMDB06372
type: Species
initial concentration: 1.0

metaR URIt5le
kinetic law: MODEL1310110001#
type: Reaction
is described by: ECO:0000134
modifier: MODEL1310110001#
fast: false
is: SBO:0000185
name: uridine transport in via sodium symport (1:2)
reversible: false
reactant: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (64078.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:

metaM e4hglu m
is: SBO:0000247
initial amount: NaN
has only substance units: false
name: erythro-4-hydroxy-L-glutamate(1-)
is: HMDB02273
constant: false
is: CHEBI:6331
type: Species
boundary condition: false
notes: FORMULA: C5H8NO5 CHARGE: -1 INCHI: InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/p-1/t2-,3+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01663 EHMN_ABBREVIATION: C05947
initial concentration: 1.0

metaM 2octpencoa m
initial concentration: 1.0
type: Species
initial amount: NaN
constant: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/5280355
notes: FORMULA: C39H56N7O17P3S CHARGE: -4
has only substance units: false
boundary condition: false
name: 2,6,9,12,15-octadecapentenoylcoa

http://identifiers.org/biomodels.db/MODEL1310110001#_0208b5e1_6197_40fb_8077_051703d47b99
is encoded by: hsa:55967
boundary condition: true
initial amount: NaN
has only substance units: false
is: F8VQS7
initial concentration: NaN
is: SBO:0000252
name: NDUFA12
constant: false
type: Species

metaM chsterol e
initial concentration: 1.0
is: CHEBI:16113
boundary condition: false
name: cholesterol
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
initial amount: NaN
is: SBO:0000247
has only substance units: false
constant: false
is: HMDB00067
type: Species

metaM xoldiolone c
has only substance units: false
type: Species
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: HMDB02197
boundary condition: false
constant: false
is: CHEBI:28477

metaM 5adtststerone e
notes: FORMULA: C19H30O2 CHARGE: 0 INCHI: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1 EHMN_ABBREVIATION: C03917
name: 17beta-hydroxy-5alpha-androstan-3-one
is: SBO:0000247
type: Species
initial amount: NaN
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: CHEBI:16330
is: HMDB02961

metaR DOLASNT Uer
notes: GENE_ASSOCIATION: (6185.1 and 1650.1 and 6184.1 and 1603.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.119 Confidence Level: 0 AUTHORS: PMID:8413235,PMID:9367678 NOTES:NCD
type: Reaction
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000
reversible: false
is: SBO:0000176
product: MODEL1310110001#
reactant: MODEL1310110001#
name: Dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase (uterus)
is version of: http://identifiers.org/ec-code/2.4.1.119
fast: false

metaR r1560
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185

metaM ksii core2 deg1 l
boundary condition: false
name: keratan sulfate II (core 2-linked), degradation product 1
is: SBO:0000247
notes: FORMULA: C70H113N5O59S3X CHARGE: -3
constant: false
is: CHEBI:57737
initial concentration: 1.0
is: HMDB00868
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_8471d3d6_2966_4a96_9f8f_18044e570c3e
is encoded by: hsa:4830
initial concentration: NaN
type: Species
has only substance units: false
constant: false
is: P15531
name: NME1
boundary condition: true
is: SBO:0000252
initial amount: NaN

metaR GLCNACASE1ly
kinetic law: MODEL1310110001#
name: alpha-N-acetylglucosaminidase, lysosomal
type: Reaction
reversible: false
product: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.50

metaM leuktrC4 e
constant: false
type: Species
is: CHEBI:57973
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
is: HMDB01198
is: SBO:0000247
boundary condition: false
has only substance units: false
name: leukotriene C4(2-)
initial amount: NaN
initial concentration: 1.0

metaM glx m
has only substance units: false
initial concentration: 1.0
is: CHEBI:36655
boundary condition: false
is: HMDB00119
is: SBO:0000247
constant: false
initial amount: NaN
name: glyoxylate
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
type: Species

metaM dcmp c
is: CHEBI:57566
is: SBO:0000247
type: Species
is: C00239
boundary condition: false
initial concentration: 1.0
is: HMDB01202
notes: FORMULA: C9H12N3O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
constant: false
initial amount: NaN
has only substance units: false
name: dCMP

metaR FACOAL2252
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000269
modifier: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
fast: false
name: fatty-acid--CoA ligase
is: SBO:0000176
reactant: MODEL1310110001#
reversible: true

metaM uppg3 c
initial concentration: 1.0
is: C01051
boundary condition: false
constant: false
is: CHEBI:57308
is: HMDB01086
type: Species
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C40H36N4O16 CHARGE: -8 HEPATONET_1.0_ABBREVIATION: HC00643 EHMN_ABBREVIATION: C01051
name: Uroporphyrinogen III
has only substance units: false

metaR r1561
is: SBO:0000185
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction

metaR RE0830N
kinetic law: MODEL1310110001#
is: SBO:0000176
reactant: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (5092.1) or (84105.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
is version of: http://identifiers.org/ec-code/4.2.1.96
type: Reaction
modifier: MODEL1310110001#
product: MODEL1310110001#
fast: false
name: RE0830
reversible: true

metaR S3TASE2ly
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 4 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
name: N-acetylglucosamine-3-sulfatase, lysosomal
is described by: ECO:0000000
fast: false
is: SBO:0000176
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
reversible: true
product: MODEL1310110001#

metaR EX tststerone LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Testosterone exchange
type: Reaction

metaR HEXDIACTD
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of hexadecanedioc acid by diffusion
type: Reaction

metaR OCTDECE1CRNe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-octadecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_19db1cec_98a1_4036_934b_0d3abc06ab23
boundary condition: true
initial amount: NaN
is encoded by: hsa:AI373818
name: _AI373818_1_m
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species

metaR FACOAL2251
kinetic law: MODEL1310110001#
reversible: true
fast: false
name: fatty-acid--CoA ligase
is described by: ECO:0000000
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
type: Reaction
is: SBO:0000176
product: MODEL1310110001#

metaM hdcea r
is: CHEBI:32372
is: SBO:0000247
has only substance units: false
constant: false
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
name: palmitoleate
notes: FORMULA: C16H29O2 CHARGE: -1 INCHI: InChI=1S/C16H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h7-8H,2-6,9-15H2,1H3,(H,17,18)/p-1/b8-7- HEPATONET_1.0_ABBREVIATION: HC01981 EHMN_ABBREVIATION: CE0850
is: HMDB03229

metaR DHCR72r
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.1.21
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:15670717 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
product: MODEL1310110001#
name: 7-dehydrocholesterol reductase
reversible: false
is described by: ECO:0000269
type: Reaction
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_9fded122_fed8_44e1_939f_1993fd951b2e
type: Species
name: GUCY1B2
boundary condition: true
constant: false
is encoded by: hsa:2974
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN

metaM leu L c
type: Species
name: L-leucine
initial amount: NaN
is: CHEBI:15603
constant: false
is: HMDB00687
boundary condition: false
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial concentration: 1.0

metaR C50CPT1
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of isovalerylcarnitine
type: Reaction

metaR 4HBZCOAFm
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
is described by: ECO:0000000
kinetic law: MODEL1310110001#
product: MODEL1310110001#
fast: false
name: 4-hydroxybenzoyl-CoA formation
reactant: MODEL1310110001#
is: SBO:0000176
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110001#_2c7c32ce_99a9_4bc1_851c_960f75c5be9c
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
name: ADCY2
is: Q71UM8
has only substance units: false
boundary condition: true
is encoded by: hsa:108
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_ac35414a_30a4_41cc_9371_bc6b95a082d3
has only substance units: false
is: SBO:0000252
initial amount: NaN
boundary condition: true
initial concentration: NaN
name: SLC5A3
type: Species
constant: false
is: P53794
is encoded by: hsa:6526

http://identifiers.org/biomodels.db/MODEL1310110001#_66a74061_ef6e_4cfa_aae6_ba41a073ee4c
has only substance units: false
initial amount: NaN
type: Species
initial concentration: NaN
is: P28845
boundary condition: true
is encoded by: hsa:3290
name: HSD11B1
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_0e5bfcfe_0976_4956_8713_c2b717324e08
name: PRPS1L1
is: P21108
is: SBO:0000252
is encoded by: hsa:221823
initial concentration: NaN
type: Species
constant: false
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_760b3a3f_27b5_4780_9943_111617b6e002
boundary condition: true
initial concentration: NaN
is encoded by: hsa:205
type: Species
is: SBO:0000252
name: AK4
has only substance units: false
constant: false
initial amount: NaN

metaR r0193
notes: GENE_ASSOCIATION: SUBSYSTEM: Cysteine Metabolism EC Number: 4.4.1.1 Confidence Level: 0 AUTHORS: PMID:10212249,PMID:629532 NOTES:
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
name: L-Cysteine L-homocysteine-lyase (deaminating) Cysteine metabolism EC:4.4.1.1

http://identifiers.org/biomodels.db/MODEL1310110001#_446d1e08_6eb9_41e6_b3fb_88137ae76c12
constant: false
boundary condition: true
has only substance units: false
is encoded by: hsa:6536
initial amount: NaN
is: SBO:0000252
is: P48067
type: Species
name: SLC6A9
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_1f385388_4c4e_47cf_9fe7_03f9b1dcaf20
is encoded by: hsa:23530
has only substance units: false
name: NNT
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_8d76b509_c565_4668_b822_57755d35dfce
constant: false
initial amount: NaN
name: PLA2G1B
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P04054
is encoded by: hsa:5319
type: Species
boundary condition: true

metaR DOLPMT1 Uer
is version of: http://identifiers.org/ec-code/2.4.1.258
product: MODEL1310110001#
reversible: false
type: Reaction
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (10195.4) or (10195.1) or (10195.3) or (10195.2) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (uterus)
is: SBO:0000176
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_fd84b161_6d81_41ac_91cb_4adec3b1200a
is: P09972
has only substance units: false
is encoded by: hsa:230
name: ALDOC
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
constant: false
type: Species

metaR NBAHH ir
notes: GENE_ASSOCIATION: (84735.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 3.4.13.3 Confidence Level: 1 AUTHORS: PMID:4026801 NOTES:NAME Nalpha-(beta-alanyl)-L-histidine hydrolase DEFINITION Carnosine + H2O <=> beta-Alanine + L-Histidine SAB made irreversible for human
is: SBO:0000176
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: Nalpha-(beta-alanyl)-L-histidine hydrolase IR
is version of: http://identifiers.org/ec-code/3.4.13.20
is described by: ECO:0000134
type: Reaction
reversible: false
reactant: MODEL1310110001#
modifier: MODEL1310110001#
fast: false

metaR AG13T4g
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
notes: GENE_ASSOCIATION: (11041.1) or (10678.1) or (93010.1) or (10331.1) or (374907.1) or (146712.1) or (374907.2) or (10678.2) or (79369.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000176
reversible: false
is described by: ECO:0000000

metaM ura c
has only substance units: false
name: Uracil
initial amount: NaN
is: C00106
boundary condition: false
type: Species
initial concentration: 1.0
constant: false
is: HMDB00300
is: SBO:0000247
notes: FORMULA: C4H4N2O2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
is: CHEBI:17568

http://identifiers.org/biomodels.db/MODEL1310110001#_e04043dd_833d_4f18_8252_74866143b0d0
is: SBO:0000252
initial concentration: NaN
has only substance units: false
is encoded by: hsa:4833
is: O00746
name: NME4
boundary condition: true
constant: false
initial amount: NaN
type: Species

metaR r2108
reactant: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
is described by: ECO:0000000
modifier: MODEL1310110001#
type: Reaction

metaM fol e
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
constant: false
notes: FORMULA: C19H18N7O6 CHARGE: -1
type: Species
name: Folate
is: HMDB00121
boundary condition: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_ea47ae8c_e3c7_45d9_8606_d292fcd81cac
is encoded by: hsa:5331
type: Species
initial concentration: NaN
boundary condition: true
name: PLCB3
is: SBO:0000252
initial amount: NaN
is: G5E960
constant: false
has only substance units: false

metaR KHte
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
name: KHte
fast: false
is: SBO:0000185
product: MODEL1310110001#
reversible: true
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_ccc36359_077f_4afa_8d8c_ae71ebd19d3d
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:343
has only substance units: false
constant: false
boundary condition: true
name: AQP8
is: O94778
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_3e58891c_0fcc_4deb_9227_590a728ab9aa
type: Species
constant: false
name: PTDSS1
is encoded by: hsa:9791
is: SBO:0000252
has only substance units: false
boundary condition: true
is: P48651
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_ea922757_cab2_4d96_b0b8_c9be4fa890b7
initial amount: NaN
is: Q99798
is: SBO:0000252
name: ACO2
boundary condition: true
is encoded by: hsa:50
initial concentration: NaN
has only substance units: false
type: Species
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_b22a8979_b8af_4ee8_9255_438c220c66bb
constant: false
type: Species
is: Q02127
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: DHODH
is encoded by: hsa:1723

http://identifiers.org/biomodels.db/MODEL1310110001#_8010fd89_c105_4136_b038_1966a1477252
is: P52790
boundary condition: true
type: Species
is encoded by: hsa:3101
constant: false
initial amount: NaN
initial concentration: NaN
name: HK3
has only substance units: false
is: SBO:0000252

metaR r2109
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000185
modifier: MODEL1310110001#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_f3b7dab5_9252_46bb_b372_8047c7fe3e39
boundary condition: true
constant: false
name: ST3GAL3
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:6487

metaM leu L e
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:15603
boundary condition: false
has only substance units: false
constant: false
name: L-leucine
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
is: HMDB00687

metaR PEROXx
is version of: http://identifiers.org/ec-code/1.1.1.35
name: peroxisomal lumped long chain fatty acid oxidation
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3295.1 and 8310.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:11591435,PMID:12814641,PMID:15599942,PMID:1679347,PMID:7487879,PMID:8188243 NOTES:lumped peroxisomal alpha and beta oxidation pristanoyl-CoA -> 4,8 diemthylnonanoyl-CoA (result of compound not known) stoichiometry for O2 is questionable at present no fad in peroxisome - 1st step of beta ox is acyl-co oxidase (not reductase) NJ
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
modifier: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.16
is: SBO:0000176
product: MODEL1310110001#
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: false

metaM glutcoa m
type: Species
is: SBO:0000247
name: glutaryl-CoA(5-)
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00411 EHMN_ABBREVIATION: C00527
is: CHEBI:57378
is: HMDB01339
initial concentration: 1.0

metaR PRISTtx
is: SBO:0000185
reactant: MODEL1310110001#
reversible: true
type: Reaction
is described by: ECO:0000000
product: MODEL1310110001#
name: prist peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:Mechanism not known, see PMID 11591435 for justification. NJ
fast: false
kinetic law: MODEL1310110001#

metaR r0191
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.2.1.24
fast: false
name: UTP:D-fructose-6-phosphate 1-phosphotransferase EC:2.7.1.11
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (7915.1) or (9856.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 2.7.1.11 Confidence Level: 0 AUTHORS: PMID:11945275,PMID:4276999 NOTES:
modifier: MODEL1310110001#
reversible: false
is: SBO:0000176

metaR ADSL2
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Purine synthesis EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
product: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#
is described by: ECO:0000269
fast: false
type: Reaction
is: SBO:0000176
name: adenylosuccinate lyase
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.3.2.2

http://identifiers.org/biomodels.db/MODEL1310110001#_e0df4f66_c582_4822_8660_8d6d60cc1f4b
initial amount: NaN
has only substance units: false
boundary condition: true
is: Q9BRB3
initial concentration: NaN
name: PIGQ
constant: false
type: Species
is encoded by: hsa:9091
is: SBO:0000252

metaM glyc3p c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
name: Glycerol 3-phosphate
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
constant: false
is: CHEBI:57597
is: HMDB00126
is: C00093

metaR N3Tg
reactant: MODEL1310110001#
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
is described by: ECO:0000000
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.122
fast: false
is: SBO:0000176
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (56913.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.122 Confidence Level: 0 AUTHORS: PMID:11677243 NOTES:NCD
type: Reaction
product: MODEL1310110001#
reversible: false

metaM gluside hs g
initial amount: NaN
initial concentration: 1.0
name: D-glucosyl-N-acylsphingosine
constant: false
has only substance units: false
type: Species
is: CHEBI:18368
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
boundary condition: false
is: SBO:0000247

metaR HS2ly
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.10.1.1
fast: false
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: heparan-N-sulfatase, lysosomal
type: Reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD

metaR r2106
is described by: ECO:0000000
product: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
modifier: MODEL1310110001#
fast: false

metaM ura e
initial amount: NaN
type: Species
has only substance units: false
constant: false
is: HMDB00300
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C4H4N2O2 CHARGE: 0 INCHI: InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8) HEPATONET_1.0_ABBREVIATION: HC00106 EHMN_ABBREVIATION: C00106
name: uracil
is: CHEBI:17568

metaR GLAl
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.22
notes: GENE_ASSOCIATION: (2717.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.2.1.22 Confidence Level: 4 AUTHORS: PMID:11775551,PMID:11828341,PMID:15003450,PMID:2836863 NOTES:NJ
modifier: MODEL1310110001#
is described by: ECO:0000000
fast: false
reversible: false
is: SBO:0000176
type: Reaction
reactant: MODEL1310110001#
name: galactosidase, alpha

metaM pro L m
is: CHEBI:17203
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
name: L-proline
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162
type: Species
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_2511e8ff_f817_4988_b0f6_f2868f4c78ac
constant: false
type: Species
is: F5GY65
has only substance units: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:8402
is: SBO:0000252
name: SLC25A11
initial amount: NaN

metaM ca2 c
initial amount: NaN
is: HMDB00464
notes: FORMULA: Ca CHARGE: 2 INCHI: InChI=1S/Ca/q+2 EHMN_ABBREVIATION: C00076
has only substance units: false
name: calcium(2+)
boundary condition: false
is: SBO:0000247
type: Species
constant: false
is: CHEBI:29108
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_3625a16f_fc7d_4525_b375_b97e2aaf565f
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:AA576959
has only substance units: false
is: SBO:0000252
boundary condition: true
type: Species
name: _AA576959_1_c

metaR G14T10g
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.22
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.38
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (9334.1) or (2683.1) or (8703.1) or (8704.2) or (8704.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate I biosynthesis NCD
product: MODEL1310110001#
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#

metaM o2s m
notes: FORMULA: O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
initial amount: NaN
type: Species
is: HMDB02168
name: Superoxide anion
is: CHEBI:18421
initial concentration: 1.0
boundary condition: false
is: C00704
has only substance units: false
constant: false
is: SBO:0000247

metaM acac e
name: acetoacetate
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705
initial concentration: 1.0
is: HMDB00060
has only substance units: false
initial amount: NaN
boundary condition: false

metaM dutp c
is: C00460
type: Species
initial concentration: 1.0
is: CHEBI:17625
has only substance units: false
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false
initial amount: NaN
is: HMDB01191
boundary condition: false
name: dUTP
is: SBO:0000247

metaM chsterol c
boundary condition: false
type: Species
name: cholesterol
is: CHEBI:16113
is: SBO:0000247
has only substance units: false
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
initial amount: NaN
initial concentration: 1.0
constant: false
is: HMDB00067

metaR r2107
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
fast: false
reversible: true
reactant: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#

metaR EX co2 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CO2 exchange
type: Reaction

metaR EX cmp LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: CMP exchange
type: Reaction

metaM ksi deg10 l
type: Species
name: keratan sulfate I, degradation product 10
initial amount: NaN
is: CHEBI:57455
boundary condition: false
is: HMDB01354
constant: false
has only substance units: false
notes: FORMULA: C188H302N13O163S9 CHARGE: -9
is: SBO:0000247
initial concentration: 1.0

metaM acmana c
initial concentration: 1.0
notes: FORMULA: C8H15NO6 CHARGE: 0 INCHI: InChI=1S/C8H15NO6/c1-4(12)9-5(2-10)7(14)8(15)6(13)3-11/h2,5-8,11,13-15H,3H2,1H3,(H,9,12)/t5-,6-,7-,8-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00474 EHMN_ABBREVIATION: C00645
constant: false
type: Species
is: CHEBI:17122
boundary condition: false
is: HMDB01129
initial amount: NaN
has only substance units: false
is: SBO:0000247
name: N-acetyl-D-mannosamine

metaM lnlncgcrn m
is: HMDB06318
boundary condition: false
type: Species
is: SBO:0000247
has only substance units: false
name: gamma-linolenyl carnitine
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1

metaM mlthf c
is: CHEBI:15636
boundary condition: false
name: 5,10-Methylenetetrahydrofolate
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: HMDB01533
constant: false
initial concentration: 1.0
is: C00143
type: Species

metaM dece3coa x
initial amount: NaN
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial concentration: 1.0
boundary condition: false
type: Species
has only substance units: false
constant: false
name: 3-decenoylcoa
is: http://identifiers.org/pubchem.compound/16019966
is: SBO:0000247

metaR ADSL1
reversible: false
reactant: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000269
fast: false
is version of: http://identifiers.org/ec-code/4.3.2.2
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (158.1) or (158.2) SUBSYSTEM: Nucleotide interconversion EC Number: 4.3.2.2 Confidence Level: 4 AUTHORS: PMID:1302001,PMID:2004782 NOTES:
is: SBO:0000176
name: adenylosuccinate lyase
type: Reaction
kinetic law: MODEL1310110001#

metaR C180CPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1528846,PMID:1988962 NOTES:TV
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
name: carnitine O-stearoyl transferase
fast: false
kinetic law: MODEL1310110001#
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction

metaM 4ppcys c
is: C04352
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: CHEBI:59458
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine
constant: false
type: Species
notes: FORMULA: C12H20N2O9PS CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
initial amount: NaN
has only substance units: false
is: HMDB01117

metaM 3octdece1coa m
type: Species
is: http://identifiers.org/pubchem.compound/5280355
name: 3-hydroxyoctadecenoylcoa
constant: false
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
boundary condition: false

metaM pro L c
name: L-proline
boundary condition: false
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
constant: false
is: SBO:0000247
initial concentration: 1.0
is: CHEBI:17203
initial amount: NaN
is: HMDB00162
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_89c3c606_50d6_4bdc_aea5_46ab5eed6c49
has part: Q07837
is encoded by: hsa:6519
is encoded by: hsa:11136
boundary condition: true
name: SLC7A9:SLC3A1
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000297
has part: P82251

metaM nh4 x
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
constant: false
is: CHEBI:28938
initial amount: NaN
boundary condition: false
is: SBO:0000247
is: HMDB00051
is: C01342
type: Species
name: Ammonium
has only substance units: false
initial concentration: 1.0

metaR r1566
product: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
fast: false

metaR 34HPPOR
notes: GENE_ASSOCIATION: (3242.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.13.11.27 Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000269
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
name: 4-Hydroxyphenylpyruvate:oxygen oxidoreductase
fast: false
is version of: http://identifiers.org/ec-code/1.13.11.27
modifier: MODEL1310110001#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110001#_1182bb55_367f_496d_8472_ab1dbf6affbb
has only substance units: false
initial amount: NaN
name: SLC25A26
is encoded by: hsa:115286
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is: Q70HW3
constant: false

metaM hyptaur c
initial concentration: 1.0
name: Hypotaurine
is: HMDB00965
boundary condition: false
is: CHEBI:16668
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
has only substance units: false
notes: FORMULA: C2H7NO2S CHARGE: 0 INCHI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) HEPATONET_1.0_ABBREVIATION: HC00406 EHMN_ABBREVIATION: C00519

metaR RE0830C
type: Reaction
name: RE0830
reactant: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 4.2.1.96 Confidence Level: 0 AUTHORS: PMID:10727395,PMID:1355046,PMID:1988938 NOTES:
product: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
reversible: true

metaR r2104
is described by: ECO:0000000
is: SBO:0000185
modifier: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reversible: true

metaM glx x
is: CHEBI:36655
is: SBO:0000247
type: Species
is: HMDB00119
boundary condition: false
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
has only substance units: false
name: glyoxylate
constant: false
initial amount: NaN
initial concentration: 1.0

metaR DOPAt4 2 r
is described by: ECO:0000269
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6530.1) or (6531.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12719981 NOTES:SAB
fast: false
kinetic law: MODEL1310110001#
name: Dopamine reversible transport in via sodium symport (1:2)
reactant: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_0a1791bd_dce0_4110_a323_e0100e58ac06
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: Q8WUX1
is encoded by: hsa:92745
name: SLC38A5
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_bdf9e170_0e57_4dc0_9d91_5d5054f634d3
constant: false
is encoded by: hsa:127
is: SBO:0000252
type: Species
name: ADH4
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
is: P08319

http://identifiers.org/biomodels.db/MODEL1310110001#_5977436a_4511_4cb2_bcf6_374bd0d8b06a
constant: false
is: SBO:0000252
name: PNP
initial amount: NaN
boundary condition: true
initial concentration: NaN
type: Species
is: P00491
is encoded by: hsa:4860
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_e815b37a_ef13_415b_a146_71cacff01a5e
has only substance units: false
type: Species
initial concentration: NaN
is: SBO:0000252
is: P16278
initial amount: NaN
boundary condition: true
constant: false
name: GLB1
is encoded by: hsa:2720

metaR 3MLDAt
reactant: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11411609 NOTES:SAB
name: 3MLDA extracellular transport via diffusion
fast: false
is described by: ECO:0000000

metaR FAOXC122m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)m
type: Reaction

metaR LYStm
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is described by: ECO:0000269
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#
name: Lysine mitochondrial transport via ornithine carrier
is: SBO:0000185
type: Reaction
modifier: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#

metaR r1567
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
type: Reaction
reversible: true
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_5d030936_d5d0_4e33_b762_34cb5c62550b
type: Species
initial amount: NaN
constant: false
is: Q99714
name: HSD17B10
is encoded by: hsa:3028
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true

metaR r2105
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
fast: false
reversible: true
is: SBO:0000185
product: MODEL1310110001#

metaM oaa c
name: Oxaloacetate
is: C00036
constant: false
type: Species
is: HMDB00223
is: CHEBI:3338
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H2O5 CHARGE: -2
is: SBO:0000247

metaM m7mpdol L r
initial concentration: 1.0
notes: FORMULA: C1720H2828N20O570P20 CHARGE: -20
is: CHEBI:37636
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
type: Species
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
initial amount: NaN

metaM ddsmsterol r
initial amount: NaN
is: SBO:0000247
boundary condition: false
notes: FORMULA: C27H42O CHARGE: 0 INCHI: InChI=1S/C27H42O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9-10,19,21,23-25,28H,6,8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01373
initial concentration: 1.0
has only substance units: false
type: Species
is: HMDB03896
name: 7-dehydrodesmosterol
constant: false
is: CHEBI:27910

metaR M14NTg
fast: false
type: Reaction
notes: GENE_ASSOCIATION: (4248.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.144 Confidence Level: 0 AUTHORS: NOTES:NCD
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.144
name: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
is: SBO:0000176
is described by: ECO:0000000
reversible: false
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_1df530a1_ae53_40a6_9769_87fbade98817
is encoded by: hsa:4967
boundary condition: true
type: Species
constant: false
is: Q02218
initial concentration: NaN
name: OGDH
is: SBO:0000252
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_c8f3d16c_c1f9_4e4e_ba97_392bb8a97ba9
initial amount: NaN
name: FLAD1
is encoded by: hsa:80308
initial concentration: NaN
is: SBO:0000252
is: Q8NFF5
constant: false
boundary condition: true
type: Species
has only substance units: false

metaM fol c
is: HMDB00121
constant: false
has only substance units: false
name: Folate
type: Species
notes: FORMULA: C19H18N7O6 CHARGE: -1
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_d411f21e_132e_477f_ad2f_139b5a9745b0
is encoded by: hsa:1356
is: SBO:0000252
name: CP
initial amount: NaN
is: P00450
initial concentration: NaN
constant: false
type: Species
has only substance units: false
boundary condition: true

metaR H2O2tn
reversible: true
kinetic law: MODEL1310110001#
is described by: ECO:0000000
name: hydrogen peroxide nuclear transport
product: MODEL1310110001#
type: Reaction
is: SBO:0000185
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:it

http://identifiers.org/biomodels.db/MODEL1310110001#_4781519f_1707_43f4_8b1b_72c13c6311ce
has only substance units: false
initial amount: NaN
name: ADA
constant: false
is: P00813
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:100
initial concentration: NaN

metaR r1568
product: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaM ksi deg27 l
type: Species
boundary condition: false
is: HMDB00143
name: keratan sulfate I, degradation product 27
is: SBO:0000247
notes: FORMULA: C104H169N7O88S4 CHARGE: -4
is: CHEBI:12936
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN

metaR r0552
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.5.1
reactant: MODEL1310110001#
name: p-cumic alcohol:NAD+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
fast: false
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (AF080579.1) or (AI348006.1) or (6389.1) or (6390.1) or (6391.1) or (6392.1) or (642502.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
reversible: true

metaR r2102
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
product: MODEL1310110001#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
reactant: MODEL1310110001#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_a6d0c6fb_89bf_4ec9_9085_23d49f1a00d3
initial amount: NaN
initial concentration: NaN
constant: false
name: _AA278423_1_m
has only substance units: false
boundary condition: true
is: SBO:0000252
type: Species
is encoded by: hsa:AA278423

metaM dolichol U c
type: Species
initial amount: NaN
constant: false
name: Dolichol, human uterine homolog
has only substance units: false
initial concentration: 1.0
is: CHEBI:16091
boundary condition: false
is: SBO:0000247
notes: FORMULA: C1025H1680O10 CHARGE: 0

metaM o2s x
is: CHEBI:18421
type: Species
initial concentration: 1.0
has only substance units: false
boundary condition: false
is: SBO:0000247
is: HMDB02168
name: superoxide
initial amount: NaN
constant: false
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704

http://identifiers.org/biomodels.db/MODEL1310110001#_5f262720_f645_4cd0_81da_46244682d1a0
initial amount: NaN
has only substance units: false
type: Species
name: _AI818585_1_c
is encoded by: hsa:AI818585
boundary condition: true
is: SBO:0000252
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_042567c2_2c75_426d_aa61_bff858e8072c
is encoded by: hsa:6391
type: Species
name: SDHC
initial concentration: NaN
has only substance units: false
is: Q99643
constant: false
is: SBO:0000252
initial amount: NaN
boundary condition: true

metaR FAOXC163x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)x
type: Reaction

metaR r1569
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000185
reactant: MODEL1310110001#
reversible: true

metaR GK1
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.8
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
name: guanylate kinase (GMP:ATP)
type: Reaction
modifier: MODEL1310110001#
is described by: ECO:0000269
is: SBO:0000176

metaR S6T18g
notes: GENE_ASSOCIATION: (8534.1) or (9469.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:12403612,PMID:8991509,PMID:9405439,PMID:9714738 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/2.8.2.21
reversible: false
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.8.2.17
reactant: MODEL1310110001#
modifier: MODEL1310110001#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_91c8714b_e8d8_4798_860e_2e0f3559ad88
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is encoded by: hsa:11001
constant: false
initial amount: NaN
is: SBO:0000252
is: O14975
name: SLC27A2

metaR FAOXC164C163x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:4-->C16:3)x
type: Reaction

metaR r0553
product: MODEL1310110001#
is: SBO:0000176
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.2.1.8 Confidence Level: 0 AUTHORS: PMID:10505788,PMID:7646513 NOTES:
name: p-Cumic alcohol:NADP+ oxidoreductase Glycine, serine and threonine metabolism EC:1.2.1.8
reversible: true
fast: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110001#

metaR r2103
fast: false
kinetic law: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
is described by: ECO:0000000
product: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
type: Reaction
is: SBO:0000185

metaM gluside hs r
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
name: D-glucosyl-N-acylsphingosine
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: CHEBI:18368
boundary condition: false
constant: false
is: SBO:0000247
type: Species

metaM ksi pre18 g
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
is: CHEBI:58053
is: C00130
name: keratan sulfate I biosynthesis, precursor 18
is: HMDB00175
notes: FORMULA: C163H262N11O132S5X CHARGE: -6
type: Species
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_a255a7df_4823_4c3d_a949_6b83c29577c9
boundary condition: true
name: SLC17A2
type: Species
initial concentration: NaN
is encoded by: hsa:10246
has only substance units: false
is: SBO:0000252
is: O00624
initial amount: NaN
constant: false

metaR ADK3m
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.10
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (50808.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:11485571 NOTES:NCD
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
name: adentylate kinase (GTP)

metaM 2dr5p c
has only substance units: false
initial amount: NaN
boundary condition: false
is: CHEBI:57651
is: SBO:0000247
name: 2-deoxy-D-ribose 5-phosphate(2-)
type: Species
notes: FORMULA: C5H9O7P CHARGE: -2 INCHI: InChI=1S/C5H11O7P/c6-2-1-4(7)5(8)3-12-13(9,10)11/h2,4-5,7-8H,1,3H2,(H2,9,10,11)/p-2/t4-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00490 EHMN_ABBREVIATION: C00673
is: HMDB01031
constant: false
initial concentration: 1.0

metaM 2decdicoa x
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
has only substance units: false
name: 2,7-decadienoylcoa
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_d12195f8_5228_4a61_9ded_5bb7fafe02b1
has only substance units: false
type: Species
initial amount: NaN
initial concentration: NaN
is: O75354
is: SBO:0000252
boundary condition: true
name: ENTPD6
constant: false
is encoded by: hsa:955

metaM dutp m
initial amount: NaN
has only substance units: false
name: dUTP
is: HMDB01191
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
is: CHEBI:17625
is: SBO:0000247
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460

http://identifiers.org/biomodels.db/MODEL1310110001#_eaea889d_336a_49ba_ab9b_a1e509735e9d
is: SBO:0000252
type: Species
name: DHFR
has only substance units: false
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:1719
is: P00374
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_6916721c_d81e_43c8_b2ca_7ebde21af594
is: GO:0005794
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: Golgi apparatus
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110001#_b24e59ce_5f08_4b1e_99a9_c99deecf7f1e
type: Species
initial amount: NaN
is encoded by: hsa:5831
has only substance units: false
boundary condition: true
is: SBO:0000252
name: PYCR1
initial concentration: NaN
is: A6NFM2
constant: false

metaM r1p c
is: HMDB01489
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN
name: alpha-D-Ribose 1-phosphate
notes: FORMULA: C5H9O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00456 EHMN_ABBREVIATION: C00442
is: CHEBI:57720
has only substance units: false
is: C00442
type: Species
boundary condition: false

metaR r2100
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
kinetic law: MODEL1310110001#
reversible: true
is: SBO:0000185
type: Reaction
modifier: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
fast: false

metaR r1562
kinetic law: MODEL1310110001#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110001#
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110001#
is described by: ECO:0000000

metaR C3STKR2r
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000134
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
type: Reaction
name: C-3 sterol keto reductase (zymosterol)
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:12829805 NOTES:NCD ER - NJ
reversible: false

metaM ocdececrn m
is: SBO:0000247
has only substance units: false
name: 11-octadecenoyl carnitine
boundary condition: false
is: HMDB06351
type: Species
constant: false
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C25H47NO4 CHARGE: 0

metaM dutp n
is: HMDB01191
notes: FORMULA: C9H11N2O14P3 CHARGE: -4 INCHI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00369 EHMN_ABBREVIATION: C00460
constant: false
type: Species
name: dUTP
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
initial amount: NaN
has only substance units: false
is: CHEBI:17625

metaM lnlncgcrn c
name: gamma-linolenyl carnitine
is: SBO:0000247
initial amount: NaN
is: HMDB06318
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
constant: false
notes: FORMULA: C25H43NO4 CHARGE: 0 INCHI: InChI=1/C25H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(26(2,3)4)21-22-24(27)28/h9-10,12-13,15-16,23H,5-8,11,14,17-22H2,1-4H3/b10-9-,13-12-,16-15-/t23-/m0/s1

http://identifiers.org/biomodels.db/MODEL1310110001#_0eada189_2fc3_478e_952a_301e8f2556a6
initial amount: NaN
initial concentration: NaN
has only substance units: false
is: Q9H490
is: SBO:0000252
is encoded by: hsa:128869
constant: false
type: Species
name: PIGU
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_dfe81cf9_d814_4fed_befc_9532b85c555d
constant: false
has only substance units: false
is encoded by: hsa:79623
boundary condition: true
is: Q96FL9
name: GALNT14
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species

metaM leu L m
is: HMDB00687
is: CHEBI:15603
has only substance units: false
name: L-leucine
constant: false
is: SBO:0000247
notes: FORMULA: C6H13NO2 CHARGE: 0 INCHI: InChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00121 EHMN_ABBREVIATION: C00123
initial amount: NaN
boundary condition: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_70364c6f_a50d_45c6_9f56_6fb3f4d44972
name: NDUFA13
has only substance units: false
type: Species
is: Q9P0J0
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:51079
boundary condition: true
initial concentration: NaN

metaR DMHPTCRNt
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 1 AUTHORS: NOTES:dmhptcoa is 'special' because its biochemical fat isn't known NJ
kinetic law: MODEL1310110001#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110001#
name: 2,6 dimethylheptanoyl crn transport
product: MODEL1310110001#
reversible: true

metaM dece3coa m
has only substance units: false
type: Species
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C31H48N7O17P3S CHARGE: -4
initial amount: NaN
boundary condition: false
constant: false
name: 3-decenoylcoa
is: http://identifiers.org/pubchem.compound/16019966

metaM ksii core4 pre6 g
notes: FORMULA: C69H111N6O51SX CHARGE: -2
is: CHEBI:28067
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
constant: false
name: keratan sulfate II biosynthesis, precursor 6
boundary condition: false

metaM gluside hs l
initial concentration: 1.0
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
has only substance units: false
boundary condition: false
is: SBO:0000247
name: D-glucosyl-N-acylsphingosine
initial amount: NaN
constant: false
type: Species
is: CHEBI:18368

metaM mlthf m
constant: false
notes: FORMULA: C20H21N7O6 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00140 EHMN_ABBREVIATION: C00143
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:15636
is: HMDB01533
type: Species
name: 5,10-Methylenetetrahydrofolate
is: SBO:0000247
initial concentration: 1.0
is: C00143

metaR r2101
fast: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11136.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12739169 NOTES:
reactant: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
name: Major Facilitator(MFS) TCDB:2.A.1.13.1

metaR PCHOLPm hs
name: choline phosphatase
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.4.4
is described by: ECO:0000269
fast: false
reactant: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
is: SBO:0000176
reversible: false
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (5337.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 3.1.4.4 Confidence Level: 4 AUTHORS: PMID:11481335,PMID:8530346 NOTES:NJ

metaM tettet6coa c
initial concentration: 1.0
boundary condition: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205481
type: Species
is: HMDB06516
constant: false
is: C16171
name: tetracosatetraenoyl coenzyme A
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1

metaR r1563
type: Reaction
reactant: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110001#
fast: false

metaR C142CPT1
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of tetradecadienoylcarnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_5599a8e4_3c11_495f_8bc5_972bff21b812
constant: false
initial concentration: NaN
is encoded by: hsa:5092
is: SBO:0000252
name: PCBD1
boundary condition: true
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_6156512f_66bc_465b_872e_ff1919d15be7
has only substance units: false
initial concentration: NaN
is encoded by: hsa:29920
constant: false
type: Species
boundary condition: true
initial amount: NaN
name: PYCR2
is: Q96C36
is: SBO:0000252

metaR IPDDIx
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/5.3.3.2
notes: GENE_ASSOCIATION: (3422.1) or (91734.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.3.3.2 Confidence Level: 4 AUTHORS: PMID:11111079 NOTES:peroxisomal version - NJ
type: Reaction
reactant: MODEL1310110001#
is described by: ECO:0000134
reversible: true
is: SBO:0000176
fast: false
modifier: MODEL1310110001#
name: isopentenyl-diphosphate D-isomerase
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_6bc7303d_99f9_4435_af6b_e2114b7a1a1c
name: LDHAL6A
type: Species
initial concentration: NaN
is encoded by: hsa:160287
has only substance units: false
boundary condition: true
initial amount: NaN
is: Q6ZMR3
constant: false
is: SBO:0000252

metaM pro L e
notes: FORMULA: C5H9NO2 CHARGE: 0 INCHI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00145
is: HMDB00162
type: Species
initial amount: NaN
constant: false
is: CHEBI:17203
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: L-proline
boundary condition: false

metaR ETF
reactant: MODEL1310110001#
reversible: false
kinetic law: MODEL1310110001#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (2109.2) and (2108.1) or (2109.1) and (2108.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:3170610,PMID:7601336 NOTES:TV (5/4/05) Voet p.571
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110001#
name: electron transfer flavoprotein
modifier: MODEL1310110001#

metaR DNDPt36m
type: Reaction
fast: false
reactant: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
is described by: ECO:0000269
kinetic law: MODEL1310110001#
name: dGDP transport via dCDP antiport
reversible: false
modifier: MODEL1310110001#

metaR RE1532M
kinetic law: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7775433,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
reversible: true
reactant: MODEL1310110001#
is described by: ECO:0000000
name: RE1532
is version of: http://identifiers.org/ec-code/4.2.1.17
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_f3d76702_3137_4db7_bbdb_0647ffef21ca
is encoded by: hsa:4645
initial amount: NaN
name: MYO5B
is: Q9H6Y6
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN

metaR r2526
reversible: true
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
fast: false
kinetic law: MODEL1310110001#
is described by: ECO:0000000
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
is: SBO:0000185
type: Reaction
product: MODEL1310110001#

metaR EX 4mop LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-methyl-2-oxopentanoate
type: Reaction

metaR r1564
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_8dda502a_b489_42fc_a26b_0c4751360504
is: SBO:0000252
is encoded by: hsa:498
has only substance units: false
constant: false
is: B4DY56
boundary condition: true
name: ATP5A1
initial amount: NaN
type: Species
initial concentration: NaN

metaR r0339
is version of: http://identifiers.org/ec-code/3.1.2.2
product: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110001#
type: Reaction
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.65
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
notes: GENE_ASSOCIATION: (10965.1) or (122970.1) or (11332.1) or (570.1) or (80864.1) or (83715.1) or (5538.1) or (9374.1) or (R33828.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
is version of: http://identifiers.org/ec-code/3.1.2.22

http://identifiers.org/biomodels.db/MODEL1310110001#_4a1efd1e_2433_46f6_8f40_bd86ea8f5002
boundary condition: true
name: HPGDS
initial amount: NaN
type: Species
constant: false
has only substance units: false
is: SBO:0000252
is: O60760
initial concentration: NaN
is encoded by: hsa:27306

http://identifiers.org/biomodels.db/MODEL1310110001#_53c89846_d217_4820_a5a7_a42a0cf542a8
name: ACP1
is encoded by: hsa:52
constant: false
is: SBO:0000252
initial amount: NaN
is: Q59EH3
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN

metaM HC01180 c
name: D-tagatofuranose 1,6-bisphosphate(4-)
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58694
is: SBO:0000247
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-4-3(1-16-19(10,11)12)18-6(9,5(4)8)2-17-20(13,14)15/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4+,5+,6?/m1/s1 EHMN_ABBREVIATION: C03785
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_abdc4ff3_b960_4d89_a01c_041899eac5a4
is: SBO:0000252
initial amount: NaN
has only substance units: false
initial concentration: NaN
boundary condition: true
is: P04183
constant: false
type: Species
is encoded by: hsa:7083
name: TK1

metaR ABUTt2r
name: 4-aminobutyrate reversible transport in via proton symport
product: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (206358.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11390972,PMID:11959859 NOTES:SAB r
type: Reaction
kinetic law: MODEL1310110001#
reversible: true
is described by: ECO:0000304
is: SBO:0000185
modifier: MODEL1310110001#
fast: false

metaM CE5854 e
has only substance units: false
boundary condition: false
notes: FORMULA: C21H27O10 CHARGE: -1 INCHI: InChI=1/C21H28O10/c1-9-10(2)17-11(8-12(9)22)4-6-21(3,31-17)7-5-13(23)29-20-16(26)14(24)15(25)18(30-20)19(27)28/h8,14-16,18,20,22,24-26H,4-7H2,1-3H3,(H,27,28)/p-1/t14-,15+,16-,18-,20+,21?/m1/s1 EHMN_ABBREVIATION: CE5854
is: HMDB02710
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
name: gama-CEHC-glucuronide
type: Species
is: CHEBI:27485
constant: false

metaR C180CPT1
modifier: MODEL1310110001#
reversible: false
product: MODEL1310110001#
is described by: ECO:0000269
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.4) or (1375.2) or (126129.1) or (1375.1) or (1374.1) or (1375.3) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: PMID:1988962 NOTES:TV (see C160CRN)
is version of: http://identifiers.org/ec-code/2.3.1.21
name: production of stearoylcarnitine
type: Reaction
fast: false

metaM acac m
name: acetoacetate
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
is: CHEBI:13705
constant: false
is: HMDB00060
type: Species

metaR IDOURte
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
is described by: ECO:0000134
product: MODEL1310110001#
kinetic law: MODEL1310110001#
name: L-iduronate transport, extracellular
is: SBO:0000185
reactant: MODEL1310110001#
fast: false

metaR r1565
is: SBO:0000185
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110001#
fast: false
type: Reaction
reactant: MODEL1310110001#

metaR NDPK4n
is: SBO:0000176
reversible: true
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.6
product: MODEL1310110001#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dTDP), nuclear
fast: false
is described by: ECO:0000304
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus

metaR r1670
fast: false
modifier: MODEL1310110001#
reversible: true
is: SBO:0000185
reactant: MODEL1310110001#
name: Y+LAT2 Utilized transport
kinetic law: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110001#
type: Reaction

metaM dcmp n
type: Species
name: dCMP(2-)
initial concentration: 1.0
notes: FORMULA: C9H12N3O7P CHARGE: -2 INCHI: InChI=1S/C9H14N3O7P/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(19-8)4-18-20(15,16)17/h1-2,5-6,8,13H,3-4H2,(H2,10,11,14)(H2,15,16,17)/p-2/t5-,6+,8+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00217 EHMN_ABBREVIATION: C00239
is: CHEBI:57566
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
boundary condition: false
is: HMDB01202

metaR OCCOAtx
kinetic law: MODEL1310110001#
is: SBO:0000185
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
reactant: MODEL1310110001#
name: fatty acid intracellular transport
reversible: true
product: MODEL1310110001#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_78c45b5d_0245_4b8b_84dd_184f1000d9b9
is: SBO:0000252
initial concentration: NaN
name: CA5A
boundary condition: true
has only substance units: false
is encoded by: hsa:763
constant: false
initial amount: NaN
is: P35218
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_b2764f8c_e64e_484e_99ba_362a5f15c207
is: P30838
has only substance units: false
boundary condition: true
name: ALDH3A1
is: SBO:0000252
initial amount: NaN
constant: false
is encoded by: hsa:218
initial concentration: NaN
type: Species

metaM tettet6coa x
is: http://identifiers.org/pubchem.compound/47205481
has only substance units: false
constant: false
type: Species
name: tetracosatetraenoyl coenzyme A
notes: FORMULA: C45H70N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4-7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-/t34-,38-,39?,40+,44-/m1/s1
is: SBO:0000247
initial amount: NaN
is: HMDB06516
is: C16171
boundary condition: false
initial concentration: 1.0

metaM atp c
has only substance units: false
constant: false
type: Species
is: SBO:0000247
boundary condition: false
is: C00002
is: CHEBI:30616
initial concentration: 1.0
name: ATP(4-)
is: HMDB00538
initial amount: NaN

metaM xoltetrol m
name: 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol
type: Species
constant: false
has only substance units: false
notes: FORMULA: C27H48O4 CHARGE: 0 INCHI: InChI=1S/C27H48O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h16-25,28-31H,5-15H2,1-4H3/t16?,17-,18+,19-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 EHMN_ABBREVIATION: C05446
is: SBO:0000247
boundary condition: false
is: CHEBI:17278
initial concentration: 1.0
initial amount: NaN
is: HMDB01231

metaR r2525
is: SBO:0000185
fast: false
name: Major Facilitator(MFS) TCDB:2.A.1.44.1
reversible: true
reactant: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:

metaR EX fad LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of Flavin adenine dinucleotide oxidized
type: Reaction

metaR UDPtl
type: Reaction
fast: false
product: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - not known if it is energy dependent or not, recycling and IC transport is important to get it to other areas of the cell (e.g. plasma membrane) - translocators have been found for ER and Golgi - none found for lysosome yet so non-mechanistic transporter added - in future this will need to be revised _when_ a translocator is found NJ
reversible: true
kinetic law: MODEL1310110001#
name: udp intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110001#_e78ee6bd_0637_44cc_99db_a15c529f0923
type: Species
is: P15289
initial concentration: NaN
is encoded by: hsa:410
name: ARSA
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false

metaM 3hexdcrn c
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247
notes: FORMULA: C23H45NO5 CHARGE: 0
boundary condition: false
name: 3-hydroxyhexadecanoylcarnitine
has only substance units: false
is: HMDB13336
constant: false

metaR CYTK4
reactant: MODEL1310110001#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.3
fast: false
type: Reaction
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110001#
name: cytidylate kinase (dCMP)(GTP)
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
product: MODEL1310110001#

metaM glac c
is: HMDB06355
has only substance units: false
constant: false
name: D-glucurono-6,3-lactone
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H8O6 CHARGE: 0 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
type: Species
initial amount: NaN
is: CHEBI:18268

http://identifiers.org/biomodels.db/MODEL1310110001#_ba0c1987_34ac_4e42_8d1a_4ed00796ea86
is encoded by: hsa:1718
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true
type: Species
initial amount: NaN
is: Q15392
name: DHCR24
is: SBO:0000252

metaR ORETNtn
name: 4-oxo-retinoic acid transport, Nuclear
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
is: SBO:0000185
reactant: MODEL1310110001#
fast: false
type: Reaction

metaM pydxn c
type: Species
notes: FORMULA: C8H11NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00268 EHMN_ABBREVIATION: C00314
constant: false
initial amount: NaN
is: HMDB00239
initial concentration: 1.0
is: CHEBI:16709
boundary condition: false
has only substance units: false
is: C00314
name: Pyridoxine
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_017f7c71_0374_4aa2_84ea_74b2d7f4a45b
is: SBO:0000252
is encoded by: hsa:4704
has only substance units: false
initial concentration: NaN
constant: false
boundary condition: true
is: Q16795
type: Species
initial amount: NaN
name: NDUFA9

metaM ksi deg1 l
initial concentration: 1.0
constant: false
has only substance units: false
is: HMDB00174
name: keratan sulfate I, degradation product 1
is: CHEBI:18287
boundary condition: false
type: Species
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
initial amount: NaN
is: SBO:0000247

metaR r0559
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.3.1 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
modifier: MODEL1310110001#
is: SBO:0000176
name: aldehyde oxidase Tyrosine metabolism EC:1.2.3.1
type: Reaction
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000000
product: MODEL1310110001#
kinetic law: MODEL1310110001#

metaM ksi deg40 l
constant: false
boundary condition: false
is: HMDB00143
notes: FORMULA: C40H68N2O31 CHARGE: 0
is: SBO:0000247
initial amount: NaN
has only substance units: false
is: CHEBI:12936
type: Species
name: keratan sulfate I, degradation product 40
initial concentration: 1.0

metaR S6TASE9ly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is described by: ECO:0000000
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.1.6.4
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.4.16.5
kinetic law: MODEL1310110001#
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/3.2.1.23
name: N-acetylgalactosamine-6-sulfatase, lysosomal

metaR GLCAASE7ly
is described by: ECO:0000000
is: SBO:0000176
name: beta-glucuronidase, lysosomal
reactant: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.31
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reversible: false

metaR UMPK7n
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110001#
reversible: true
is: SBO:0000176
name: UMP kinase (dGTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
reactant: MODEL1310110001#
modifier: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
is described by: ECO:0000269
fast: false

metaR EX acac LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetoacetate exchange
type: Reaction

metaR CYTK5
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is described by: ECO:0000269
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
type: Reaction
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
product: MODEL1310110001#
name: cytidylate kinase (dCMP)
modifier: MODEL1310110001#

metaR NDP8
modifier: MODEL1310110001#
is described by: ECO:0000269
reactant: MODEL1310110001#
reversible: false
product: MODEL1310110001#
name: nucleoside-diphosphatase (dUDP)
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.9
fast: false
kinetic law: MODEL1310110001#

metaM s7p c
notes: FORMULA: C7H13O10P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01436 EHMN_ABBREVIATION: C05382
is: C05382
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: Sedoheptulose 7-phosphate
boundary condition: false
type: Species
is: HMDB01068
is: CHEBI:57483
constant: false
initial concentration: 1.0

metaR DNDPt37m
is described by: ECO:0000269
is: SBO:0000185
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
type: Reaction
modifier: MODEL1310110001#
name: dUTP transport via dTDP antiport
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: false

metaR GALASE3ly
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.23
name: beta-galactosidase, lysosomal
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.18
is described by: ECO:0000000
fast: false
reversible: false
kinetic law: MODEL1310110001#
is: SBO:0000176
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.4.16.5

http://identifiers.org/biomodels.db/MODEL1310110001#_73ac2bf9_3d76_400c_89eb_7fd84283811c
has only substance units: false
is encoded by: hsa:T83654
boundary condition: true
is: SBO:0000252
name: _T83654_1_e
initial concentration: NaN
initial amount: NaN
constant: false
type: Species

metaR r0558
reversible: true
is version of: http://identifiers.org/ec-code/1.5.1.3
is described by: ECO:0000000
fast: false
product: MODEL1310110001#
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
name: Gentisate aldehyde:NAD+ oxidoreductase Tyrosine metabolism EC:1.2.1.29
is: SBO:0000176
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (1719.1) or (HG2846-HT2983.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.29 Confidence Level: 0 AUTHORS: PMID:11569919,PMID:16143537 NOTES:
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_f2e6a7c2_a451_40ec_917a_a6b20e15a062
is: F5H8B1
initial amount: NaN
type: Species
is: SBO:0000252
name: PCYT2
initial concentration: NaN
has only substance units: false
is encoded by: hsa:5833
boundary condition: true
constant: false

metaR r0480
product: MODEL1310110001#
fast: false
name: S-Adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#

metaM atp e
name: ATP(4-)
boundary condition: false
is: C00002
constant: false
has only substance units: false
is: HMDB00538
initial amount: NaN
is: CHEBI:57299
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_4e6bc6b6_a309_4bbb_b6e1_f58c87829ca0
name: ALDH2
is: SBO:0000252
type: Species
is: P05091
constant: false
is encoded by: hsa:217
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_7efa0bc7_c0c5_4a6f_b9da_97bbbd818c95
is encoded by: hsa:8714
initial concentration: NaN
boundary condition: true
is: SBO:0000252
name: ABCC3
constant: false
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_bb080f84_bf5e_41a0_88a1_734ccce4eb85
boundary condition: true
is: SBO:0000252
is encoded by: hsa:AI971036
initial amount: NaN
has only substance units: false
initial concentration: NaN
constant: false
name: _AI971036_1_c
type: Species

metaM 3hexdcrn e
name: 3-hydroxyhexadecanoylcarnitine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
type: Species
notes: FORMULA: C23H45NO5 CHARGE: 0
boundary condition: false
is: HMDB13336
constant: false
initial amount: NaN

metaR CYTK6
is: SBO:0000176
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
type: Reaction
is described by: ECO:0000269
fast: false
reversible: true
name: cytidylate kinase (CMP,CTP)
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#

metaR PPDOx
reversible: false
is described by: ECO:0000269
product: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
name: Propane-1,2-diol:NAD+ 1-oxidoreductase
notes: GENE_ASSOCIATION: (8574.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:NCD
type: Reaction

metaR PTRCOX1
is version of: http://identifiers.org/ec-code/1.4.3.22
reversible: false
is version of: http://identifiers.org/ec-code/1.4.3.21
modifier: MODEL1310110001#
name: Putrescine:oxygen oxidoreductase (deaminating)
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110001#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (26.1) or (314.1) or (8639.1) or (314.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.4.3.6 Confidence Level: 2 AUTHORS: PMID:9119395 NOTES:SAB
product: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_fc74da4e_9687_4161_a237_d6829286b5f6
type: Species
is: SBO:0000252
has only substance units: false
is encoded by: hsa:AA526438
initial concentration: NaN
name: _AA526438_1_m
constant: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_15247d91_ebc4_4b7d_ac35_a7466327563a
has only substance units: false
name: STARD3
boundary condition: true
is encoded by: hsa:10948
type: Species
constant: false
is: B4DUY1
initial concentration: NaN
is: SBO:0000252
initial amount: NaN

metaR LEUTAm
is version of: http://identifiers.org/ec-code/2.6.1.42
fast: false
name: leucine transaminase, mitochondrial
is described by: ECO:0000269
reactant: MODEL1310110001#
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
is: SBO:0000176
type: Reaction
notes: GENE_ASSOCIATION: (587.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.1.6 Confidence Level: 4 AUTHORS: PMID:6933702,PMID:9165094 NOTES:NCD
product: MODEL1310110001#

metaR HBZOPT10m
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (27235.1) SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:15153069,PMID:1965190,PMID:7380842 NOTES:Used to make Ubiquinone-10 EC 2.5.1.- IT
type: Reaction
fast: false
modifier: MODEL1310110001#
is described by: ECO:0000269
name: Hydroxybenzoate Decaprenyltransferase
reversible: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.5.1.39
product: MODEL1310110001#
is: SBO:0000176

metaM hom L e
is: CHEBI:15699
boundary condition: false
name: L-homoserine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
is: SBO:0000247
has only substance units: false
is: HMDB00719
constant: false
type: Species
initial amount: NaN
initial concentration: 1.0

metaM dd2coa m
boundary condition: false
initial concentration: 1.0
constant: false
type: Species
has only substance units: false
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h12-13,20-22,26-28,32,43-44H,4-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b13-12+/t22-,26-,27-,28+,32-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: CHEBI:57330
is: SBO:0000247
initial amount: NaN
name: trans-dodec-2-enoyl-CoA(4-)
is: HMDB03712

http://identifiers.org/biomodels.db/MODEL1310110001#_4011d757_9c5b_4fc4_9912_a7a86b67dbb4
has only substance units: false
is: SBO:0000252
constant: false
name: FBP1
is: Q2TU34
initial concentration: NaN
initial amount: NaN
boundary condition: true
type: Species
is encoded by: hsa:2203

metaR CYTK7
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.14
is: SBO:0000176
name: cytidylate kinase (CMP,UTP)
type: Reaction
is described by: ECO:0000269
reversible: true
fast: false
product: MODEL1310110001#
reactant: MODEL1310110001#
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_daf085d7_a2b3_4ae8_8a20_48c800907a83
type: Species
name: ALPP
is encoded by: hsa:250
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
is: P05187

metaM prostgd2 c
name: prostaglandin D2(1-)
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
is: HMDB01403
constant: false
type: Species
has only substance units: false
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_43ae56cb_ef5b_455b_a4cb_1682bae1a5e1
is: SBO:0000252
initial concentration: NaN
constant: false
name: GLUD1
type: Species
boundary condition: true
is: E9KL48
has only substance units: false
initial amount: NaN
is encoded by: hsa:2746

metaM chsterol r
name: cholesterol
constant: false
is: CHEBI:16113
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
type: Species
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: HMDB00067

http://identifiers.org/biomodels.db/MODEL1310110001#_39c1035c_7d29_47ff_81f1_5ee7c3f7c3d5
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
name: ALG8
initial amount: NaN
boundary condition: true
is: A6NDW6
type: Species
is encoded by: hsa:79053

metaR CRNt
notes: GENE_ASSOCIATION: (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827517,PMID:12883891,PMID:9933568 NOTES:NCD
reversible: true
name: L-carnitine reversible transport
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000185
type: Reaction
fast: false
modifier: MODEL1310110001#
is described by: ECO:0000269

metaR G14T3g
fast: false
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
reversible: false
is version of: http://identifiers.org/ec-code/2.4.1.22
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is described by: ECO:0000000
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.90
product: MODEL1310110001#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_559fb51c_6e19_459e_876b_1bad3c900416
has only substance units: false
is: SBO:0000252
name: ST3GAL3
initial concentration: NaN
is encoded by: hsa:6487
type: Species
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_798b2a10_ab32_4707_ac73_9dd73c0c256b
boundary condition: true
is: SBO:0000252
type: Species
name: DGKZ
initial amount: NaN
constant: false
is encoded by: hsa:8525
initial concentration: NaN
has only substance units: false
is: G3V0F6

http://identifiers.org/biomodels.db/MODEL1310110001#_094c9c36_9026_4a5d_a86e_e7d6684acfe1
is: SBO:0000252
constant: false
name: ENTPD5
is: O75356
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:957
type: Species
has only substance units: false
boundary condition: true

metaM pa hs m
has only substance units: false
is: CHEBI:57739
constant: false
is: SBO:0000247
type: Species
name: phosphatidate(2-)
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2 CHARGE: -2 EHMN_ABBREVIATION: C00416
initial amount: NaN

metaR r2521
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000185
name: Utilized transport
fast: false
is described by: ECO:0000000
product: MODEL1310110001#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_98e3dc04_2364_4776_a484_18eb86e66bbf
is encoded by: hsa:C7orf24
boundary condition: true
type: Species
name: _C7orf24_1_m
constant: false
has only substance units: false
initial amount: NaN
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_8033584a_f9aa_4157_8b5f_033e0a09236e
is encoded by: hsa:204
has only substance units: false
name: AK2
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
type: Species
constant: false
boundary condition: true

metaR MI1PP
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110001#
fast: false
product: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (3612.1) or (3613.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.25 Confidence Level: 4 AUTHORS: PMID:1377913,PMID:2906139,PMID:9322233 NOTES:JLR
reversible: false
name: myo-inositol 1-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.25

metaM hom L c
type: Species
has only substance units: false
is: SBO:0000247
is: CHEBI:15699
is: HMDB00719
initial concentration: 1.0
boundary condition: false
constant: false
name: L-homoserine
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)/t3-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00239
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_51b327ba_2010_4cd9_804c_973809357461
initial amount: NaN
name: ST3GAL4
is: Q6IBE6
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6484
has only substance units: false
type: Species
boundary condition: true
constant: false

metaR GAO2g
is described by: ECO:0000269
modifier: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (9197.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:for humans - seq predicted SLC transporters have been found to have O-acetylation activity on gangliosides NJ
type: Reaction
fast: false
name: Ganglioside O-acetylation
reversible: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_b6271763_5013_4cfd_bd8c_c049452d9de1
name: HSD3B1
boundary condition: true
initial amount: NaN
is: P14060
initial concentration: NaN
constant: false
type: Species
has only substance units: false
is: SBO:0000252
is encoded by: hsa:3283

metaM 3hdcoa m
is: http://identifiers.org/pubchem.compound/16019966
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
name: (S)-3-Hydroxydecanoyl-CoA
notes: FORMULA: C31H50N7O18P3S CHARGE: -4

metaR EX maltttr LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotetraose exchange
type: Reaction

metaM prostgd2 e
initial amount: NaN
boundary condition: false
name: prostaglandin D2(1-)
is: HMDB01403
initial concentration: 1.0
type: Species
is: SBO:0000247
constant: false
is: CHEBI:57406
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1 EHMN_ABBREVIATION: C00696
has only substance units: false

metaR FAOXC102C103m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)m
type: Reaction

metaR r2520
type: Reaction
fast: false
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:15845418 NOTES:
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.2.1
is described by: ECO:0000000
reactant: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#

metaR PPDOy
is described by: ECO:0000269
type: Reaction
modifier: MODEL1310110001#
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
fast: false
is: SBO:0000176
product: MODEL1310110001#
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#

metaR EX 34dhoxpeg LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 3,4-Dihydroxyphenylethyleneglycol exchange
type: Reaction

metaM udpacgal l
has only substance units: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
boundary condition: false
name: UDP-N-acetyl-D-galactosamine(2-)
initial concentration: 1.0
is: CHEBI:57847
constant: false
is: HMDB00304
type: Species
is: SBO:0000247
initial amount: NaN

metaR ITPtn
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
is described by: ECO:0000000
reactant: MODEL1310110001#
is: SBO:0000185
name: ITP nuclear transport
kinetic law: MODEL1310110001#
product: MODEL1310110001#

metaR CYTK1
product: MODEL1310110001#
fast: false
is described by: ECO:0000269
name: cytidylate kinase (CMP)
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14

metaR MALTSULtm
is: SBO:0000185
kinetic law: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
reversible: true
modifier: MODEL1310110001#
fast: false
is described by: ECO:0000269
type: Reaction
name: Malate:thiosulfate antiport, mitochondrial
reactant: MODEL1310110001#

metaR r2309
kinetic law: MODEL1310110001#
reversible: true
fast: false
reactant: MODEL1310110001#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110001#
type: Reaction

metaR C5DCe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of glutaryl carnitine into the extra cellular fluid
type: Reaction

metaM malthx e
is: http://identifiers.org/pubchem.compound/5041
boundary condition: false
notes: FORMULA: C36H62O31 CHARGE: 0 INCHI: InChI=1/C36H62O31/c37-1-7-13(43)14(44)21(51)32(58-7)64-27-9(3-39)60-34(23(53)16(27)46)66-29-11(5-41)62-36(25(55)18(29)48)67-30-12(6-42)61-35(24(54)19(30)49)65-28-10(4-40)59-33(22(52)17(28)47)63-26-8(2-38)57-31(56)20(50)15(26)45/h7-56H,1-6H2/t7-,8-,9-,10-,11-,12-,13-,14+,15-,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31?,32-,33-,34-,35-,36-/m1/s1 EHMN_ABBREVIATION: C01936
name: Maltohexaose
constant: false
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
is: C01936

metaR FAOXC122x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:2)x
type: Reaction

metaR r0331
name: 5,6-Dihydrothymine:NAD+ oxidoreductase Pyrimidine metabolism EC:1.3.1.1
modifier: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.1 Confidence Level: 0 AUTHORS: PMID:1260500,PMID:8615641 NOTES:
kinetic law: MODEL1310110001#
fast: false
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110001#
reversible: false
type: Reaction

metaM 34hpl m
notes: FORMULA: C9H9O4 CHARGE: -1 INCHI: InChI=1S/C9H10O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8,10-11H,5H2,(H,12,13)/p-1
has only substance units: false
is: HMDB00755
initial amount: NaN
type: Species
is: SBO:0000247
name: 3-(4-hydroxyphenyl)lactate
boundary condition: false
initial concentration: 1.0
constant: false
is: CHEBI:36659

http://identifiers.org/biomodels.db/MODEL1310110001#_2aa0865f_56f9_408b_b2f9_18c1389e8cc5
boundary condition: true
initial amount: NaN
is: SBO:0000252
name: ST20
is encoded by: hsa:400410
type: Species
is: Q9HBF5
constant: false
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_15a804fd_3c85_4b49_9d4f_252322aaf443
has only substance units: false
initial concentration: NaN
is: Q8TE04
type: Species
name: PANK1
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:53354
constant: false

metaR STRDNCt
is: SBO:0000185
product: MODEL1310110001#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reversible: true
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
reactant: MODEL1310110001#
type: Reaction

metaR r2308
is: SBO:0000185
product: MODEL1310110001#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.14
kinetic law: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14579113 NOTES:
fast: false
reactant: MODEL1310110001#
type: Reaction
reversible: true

metaR CYTK2
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110001#
product: MODEL1310110001#
fast: false
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110001#
name: cytidylate kinase (dCMP)
kinetic law: MODEL1310110001#

metaR LPCHOLt
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9430701 NOTES:
type: Reaction
reversible: true
reactant: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
name: lysophosphatidylcholine transport
fast: false

metaR LTA4H
reactant: MODEL1310110001#
is described by: ECO:0000134
reversible: false
is version of: http://identifiers.org/ec-code/3.3.2.6
type: Reaction
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (4048.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 3.3.2.6 Confidence Level: 4 AUTHORS: PMID:7918238 NOTES:NJ
name: Leukotriene A-4 hydrolase
is: SBO:0000176
product: MODEL1310110001#
fast: false

metaR DOLPH Uer
type: Reaction
reversible: false
product: MODEL1310110001#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 3.1.3.51 Confidence Level: 0 AUTHORS: PMID:11425794 NOTES:
name: Dolichol-phosphate phosphohydrolase, human (uterus)
reactant: MODEL1310110001#

metaR NDP3ex
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:EC is 3.6.1.42? NCD
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.6.1.6
name: nucleoside-diphosphatase (GDP), extracellular
fast: false
reversible: false
product: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#

metaR ALAtN1
is described by: ECO:0000269
reactant: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
name: Alanine transport (Na, H coupled)
product: MODEL1310110001#
is: SBO:0000185
modifier: MODEL1310110001#
type: Reaction
fast: false
kinetic law: MODEL1310110001#

metaR r0483
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 2.6.1.22 Confidence Level: 0 AUTHORS: PMID:5773299 NOTES:
fast: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
name: (R)-3-Amino-2-methylpropanoate:2-oxoglutarate aminotransferase EC:2.6.1.22

metaM ibcoa m
is: HMDB01243
name: isobutyryl-CoA(4-)
has only substance units: false
notes: FORMULA: C25H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,34-35H,5-10H2,1-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/p-4/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00462 EHMN_ABBREVIATION: C00630
boundary condition: false
constant: false
is: CHEBI:57338
initial concentration: 1.0
initial amount: NaN
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_705d797e_f628_40ca_9ce4_dfee35366b06
constant: false
initial amount: NaN
is: Q9H0N5
name: PCBD2
boundary condition: true
is encoded by: hsa:84105
is: SBO:0000252
has only substance units: false
initial concentration: NaN
type: Species

metaR r0556
fast: false
is described by: ECO:0000000
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (AF116616.1) or (PRO1933.1) or (6319.1) or (79966.1) SUBSYSTEM: Unassigned EC Number: 2.3.1.61 Confidence Level: 0 AUTHORS: PMID:8076640,PMID:9620315 NOTES:
is version of: http://identifiers.org/ec-code/1.14.19.1
reversible: true
name: succinyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-succinyltransferase Citrate cycle (TCA cycle) EC:2.3.1.61
kinetic law: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_aebb798d_50c6_46cd_b83a_479cd9f18155
is: P57054
initial amount: NaN
has only substance units: false
name: PIGP
constant: false
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:51227
boundary condition: true
type: Species

metaR CYTK3
modifier: MODEL1310110001#
name: cytidylate kinase (CMP)(GTP)
fast: false
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (26289.1) or (26289.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: PMID:10215863 NOTES:
type: Reaction
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.3

metaR FUMTSULtm
type: Reaction
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172,PMID:4441366 NOTES:MM
name: Fumarate:thiosulfate antiport, mitochondrial
fast: false
product: MODEL1310110001#
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000269
reversible: true
kinetic law: MODEL1310110001#
is: SBO:0000185

metaR DOLPMT3 Ler
kinetic law: MODEL1310110001#
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase (liver)
fast: false
modifier: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (79087.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.130 Confidence Level: 0 AUTHORS: NOTES:NCD
reversible: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.260
product: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000000

metaR ATPH2e
is version of: http://identifiers.org/ec-code/3.6.1.5
is described by: ECO:0000269
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.6.1.6
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.5 Confidence Level: 4 AUTHORS: PMID:8955160,PMID:9676430 NOTES:IT
modifier: MODEL1310110001#
fast: false
type: Reaction
reversible: false
name: ATP diphosphohydrolase
is: SBO:0000176

metaM f26bp c
has only substance units: false
name: beta-D-fructofuranose 2,6-bisphosphate(4-)
constant: false
is: SBO:0000247
is: CHEBI:58579
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-2-6(18-20(13,14)15)5(9)4(8)3(17-6)1-16-19(10,11)12/h3-5,7-9H,1-2H2,(H2,10,11,12)(H2,13,14,15)/p-4/t3-,4-,5+,6+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00484 EHMN_ABBREVIATION: C00665
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB01047
initial amount: NaN

metaM tetdec2coa c
is: HMDB02014
type: Species
name: tetradecadienoylcoa
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_6b6b4114_b21d_46bf_9cd9_8cfc35276e6b
type: Species
is: SBO:0000252
name: AMACR
constant: false
boundary condition: true
initial concentration: NaN
is: Q3KT79
initial amount: NaN
has only substance units: false
is encoded by: hsa:23600

http://identifiers.org/biomodels.db/MODEL1310110001#_9009339c_a2f4_49ac_a150_21e2bcacd6ff
is: SBO:0000252
is encoded by: hsa:196883
name: ADCY4
has only substance units: false
constant: false
is: Q8NFM4
type: Species
initial amount: NaN
boundary condition: true
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_c4dadee6_2ba8_44ee_97a4_851347575df5
is: SBO:0000252
name: ACAD8
initial amount: NaN
is: Q6ZWP6
boundary condition: true
initial concentration: NaN
is encoded by: hsa:27034
constant: false
type: Species
has only substance units: false

metaR EX hpdca LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: heptadecanoate exchange
type: Reaction

metaM dopasf e
boundary condition: false
is: CHEBI:37946
is: HMDB06275
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: dopamine 3-O-sulfate
type: Species
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
constant: false

metaR ELAIDCPT1
reactant: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110001#
fast: false
name: carnitine O-palmitoyltransferase
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000176
type: Reaction
reversible: false
is described by: ECO:0000269

metaM acac c
type: Species
is: CHEBI:13705
boundary condition: false
name: acetoacetate
initial concentration: 1.0
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H5O3 CHARGE: -1 INCHI: InChI=1S/C4H6O3/c1-3(5)2-4(6)7/h2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00159 EHMN_ABBREVIATION: C00164
constant: false
is: SBO:0000247
is: HMDB00060

http://identifiers.org/biomodels.db/MODEL1310110001#_abb6d9d0_6ead_4a0f_9d5c_2548df7d34fb
is: Q9NYW8
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
constant: false
is encoded by: hsa:57786
initial concentration: NaN
initial amount: NaN
name: RBAK

http://identifiers.org/biomodels.db/MODEL1310110001#_a3ec899d_bf25_4da3_bbb4_78c8e5c7ebaf
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN
boundary condition: true
name: SULT1A2
initial concentration: NaN
is: P50226
constant: false
is encoded by: hsa:6799

metaM 4mptnl m
initial amount: NaN
name: 4-methylpentanal
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
is: SBO:0000247
is: HMDB01318
boundary condition: false
constant: false
is: CHEBI:17998
type: Species

metaM thr L c
is: HMDB00167
initial concentration: 1.0
is: SBO:0000247
name: L-threonine
type: Species
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
initial amount: NaN
is: CHEBI:16857

metaM 10fthf7glu e
initial amount: NaN
has only substance units: false
is: SBO:0000247
boundary condition: false
is: CHEBI:16236
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C50H57N13O25 CHARGE: -8
is: HMDB00108
name: 10-formyltetrahydrofolate-[Glu](7)

http://identifiers.org/biomodels.db/MODEL1310110001#_eab70d82_28a2_4094_9107_0a5a3657d881
initial concentration: NaN
constant: false
is: SBO:0000252
name: AK5
initial amount: NaN
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:26289

http://identifiers.org/biomodels.db/MODEL1310110001#_49d70bb1_cde8_460d_8907_b807bfcebffb
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
is: SBO:0000252
type: Species
name: SDR16C5
initial amount: NaN
is: B3KT84
is encoded by: hsa:195814

http://identifiers.org/biomodels.db/MODEL1310110001#_1f2f2f48_61d8_4b23_8064_7b2b91c8e29f
type: Species
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000297
has part: P48201
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is encoded by: hsa:518
constant: false
initial concentration: NaN

metaR r1679
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#

metaM hdcecrn m
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
initial concentration: 1.0
is: HMDB00222
constant: false
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
name: Hexadecenoyl carnitine
initial amount: NaN

metaM dmnoncoa x
initial amount: NaN
type: Species
boundary condition: false
is: HMDB11604
has only substance units: false
is: SBO:0000247
constant: false
name: 4,8 dimethylnonanoyl-CoA
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_f4331158_8296_4b99_ba4d_b7861db30c58
is encoded by: hsa:157570
type: Species
initial concentration: NaN
name: ESCO2
boundary condition: true
initial amount: NaN
constant: false
is: Q56NI9
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_43b4d63e_6a0e_469f_be45_64efff99338e
is encoded by: hsa:122970
initial concentration: NaN
type: Species
constant: false
is: Q8N9L9
name: ACOT4
is: SBO:0000252
initial amount: NaN
boundary condition: true
has only substance units: false

metaR ADNtm
type: Reaction
name: adenosine facilated transport in mitochondria
reversible: true
is: SBO:0000185
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
is described by: ECO:0000269
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (2030.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:10722669,PMID:12838422,PMID:14607828 NOTES:IT
product: MODEL1310110001#

metaM 44mzym r
initial concentration: 1.0
is: CHEBI:18364
name: 14-demethyllanosterol
type: Species
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false
is: HMDB01286
has only substance units: false
notes: FORMULA: C29H48O CHARGE: 0 INCHI: InChI=1S/C29H48O/c1-19(2)9-8-10-20(3)22-12-13-23-21-11-14-25-27(4,5)26(30)16-18-29(25,7)24(21)15-17-28(22,23)6/h9,20,22-23,25-26,30H,8,10-18H2,1-7H3/t20-,22-,23+,25+,26+,28-,29-/m1/s1 EHMN_ABBREVIATION: C05108

http://identifiers.org/biomodels.db/MODEL1310110001#_c468f448_7d5e_4a8b_a23e_0246351a9dcf
is: P50747
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:3141
name: HLCS
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_159899d2_59ba_4899_8186_ca92ef0e9bf6
is: A8MU28
name: NAE1
constant: false
is encoded by: hsa:8883
boundary condition: true
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252

metaM dopasf c
constant: false
initial concentration: 1.0
is: CHEBI:37946
is: HMDB06275
has only substance units: false
name: dopamine 3-O-sulfate
is: SBO:0000247
initial amount: NaN
type: Species
notes: FORMULA: C8H11NO5S CHARGE: 0 INCHI: InChI=1S/C8H11NO5S/c9-4-3-6-1-2-7(10)8(5-6)14-15(11,12)13/h1-2,5,10H,3-4,9H2,(H,11,12,13) EHMN_ABBREVIATION: C13690
boundary condition: false

metaM 2decdicoa m
boundary condition: false
name: 2,7-decadienoylcoa
constant: false
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C31H46N7O17P3S CHARGE: -4
is: http://identifiers.org/pubchem.compound/16019966
initial amount: NaN
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_a680f113_7122_4b03_b744_182045d68d33
has only substance units: false
type: Species
is: O43451
boundary condition: true
is: SBO:0000252
name: MGAM
constant: false
is encoded by: hsa:8972
initial concentration: NaN
initial amount: NaN

metaR DHCR243r
is version of: http://identifiers.org/ec-code/1.3.1.72
is described by: ECO:0000134
product: MODEL1310110001#
reversible: false
type: Reaction
modifier: MODEL1310110001#
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (1718.1) SUBSYSTEM: Cholesterol metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:17984220,PMID:19520779,PMID:19520780 NOTES:lanosterol -> cholesterol pathway FAD known to be cofactor, other details missing NJ
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
name: 24-dehydrocholesterol reductase [Precursor]

metaM atp n
initial amount: NaN
is: SBO:0000247
constant: false
is: CHEBI:57299
notes: FORMULA: C10H12N5O13P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00012 EHMN_ABBREVIATION: C00002
has only substance units: false
initial concentration: 1.0
name: ATP(3-)
boundary condition: false
type: Species
is: HMDB00538

metaR r0488
is: SBO:0000176
is described by: ECO:0000000
reactant: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Cholesterol metabolism EC Number: 1.1.1.34 Confidence Level: 0 AUTHORS: PMID:10698924,PMID:11108725,PMID:12454262,PMID:3745272,PMID:3883347 NOTES:
product: MODEL1310110001#
name: (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating) Biosynthesis of steroids EC:1.1.1.34
type: Reaction
fast: false
kinetic law: MODEL1310110001#

metaR EX 4nphsf LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Nitrophenyl sulfate exchange
type: Reaction

metaM peamn c
is: CHEBI:225237
name: 2-phenylethanaminium
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C8H12N CHARGE: 1 INCHI: InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2/p+1 EHMN_ABBREVIATION: C05332
is: HMDB12275

http://identifiers.org/biomodels.db/MODEL1310110001#_74f304d0_7477_4844_92a2_4715de4a3a9b
initial amount: NaN
is: SBO:0000252
name: PFKFB2
has only substance units: false
is encoded by: hsa:5208
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: O60825

metaM dolichol U r
has only substance units: false
initial amount: NaN
is: SBO:0000247
is: CHEBI:16091
notes: FORMULA: C1025H1680O10 CHARGE: 0
name: Dolichol, human uterine homolog
initial concentration: 1.0
type: Species
constant: false
boundary condition: false

metaM 10fthf6glu e
is: SBO:0000247
name: 10-formyltetrahydrofolate-[Glu](6)
constant: false
boundary condition: false
has only substance units: false
notes: FORMULA: C45H51N12O22 CHARGE: -7 INCHI: InChI=1/C45H58N12O22/c46-45-55-36-35(38(67)56-45)48-21(17-47-36)18-57(19-58)22-3-1-20(2-4-22)37(66)54-28(44(78)79)9-15-33(63)52-26(42(74)75)7-13-31(61)50-24(40(70)71)5-11-29(59)49-23(39(68)69)6-12-30(60)51-25(41(72)73)8-14-32(62)53-27(43(76)77)10-16-34(64)65/h1-4,19,21,23-28,48H,5-18H2,(H,49,59)(H,50,61)(H,51,60)(H,52,63)(H,53,62)(H,54,66)(H,64,65)(H,68,69)(H,70,71)(H,72,73)(H,74,75)(H,76,77)(H,78,79)(H4,46,47,55,56,67)/p-7/t21?,23?,24?,25?,26?,27?,28-/m1/s1
initial concentration: 1.0
is: CHEBI:16236
initial amount: NaN
is: HMDB00108
type: Species

metaM dmpp x
type: Species
has only substance units: false
name: prenyl diphosphate(3-)
is: HMDB01120
notes: FORMULA: C5H9O7P2 CHARGE: -3 INCHI: InChI=1S/C5H12O7P2/c1-5(2)3-4-11-14(9,10)12-13(6,7)8/h3H,4H2,1-2H3,(H,9,10)(H2,6,7,8)/p-3 HEPATONET_1.0_ABBREVIATION: HC00213 EHMN_ABBREVIATION: C00235
initial concentration: 1.0
boundary condition: false
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:57623

metaR FAOXC142C122x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)x
type: Reaction

metaM arachcoa x
type: Species
is: HMDB04258
initial amount: NaN
is: CHEBI:15527
name: arachidyl coenzyme A
constant: false
has only substance units: false
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C41H70N7O17P3S CHARGE: -4 INCHI: InChI=1S/C41H74N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-32(50)69-25-24-43-31(49)22-23-44-39(53)36(52)41(2,3)27-62-68(59,60)65-67(57,58)61-26-30-35(64-66(54,55)56)34(51)40(63-30)48-29-47-33-37(42)45-28-46-38(33)48/h28-30,34-36,40,51-52H,4-27H2,1-3H3,(H,43,49)(H,44,53)(H,57,58)(H,59,60)(H2,42,45,46)(H2,54,55,56)/t30-,34-,35-,36+,40-/m1/s1 EHMN_ABBREVIATION: C02041

metaR NRVNCCOAtx
kinetic law: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
fast: false
is: SBO:0000185
is described by: ECO:0000000
name: fatty acid intracellular transport
reversible: true

metaM thr L e
initial concentration: 1.0
type: Species
name: L-threonine
constant: false
initial amount: NaN
has only substance units: false
is: HMDB00167
boundary condition: false
notes: FORMULA: C4H9NO3 CHARGE: 0 INCHI: InChI=1S/C4H9NO3/c1-2(6)3(5)4(7)8/h2-3,6H,5H2,1H3,(H,7,8)/t2-,3+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00179
is: SBO:0000247
is: CHEBI:16857

metaM glyclt c
type: Species
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: CHEBI:29805
name: glycolate
constant: false
is: HMDB00115

metaR HACD1m
fast: false
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/2.3.1.16
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
notes: GENE_ASSOCIATION: (3028.1) or (3033.1) or (3030.1) and (3032.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.1.1.35 Confidence Level: 1 AUTHORS: PMID:17143551,PMID:17143552 NOTES:Same as EC 1.1.1.157 SAB mito. some physiological
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#

metaM m5mpdol U r
constant: false
has only substance units: false
is: SBO:0000247
is: CHEBI:37634
initial amount: NaN
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C1545H2540N20O470P20 CHARGE: -20

metaR RE1810M
reversible: true
is described by: ECO:0000000
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Bile acid synthesis EC Number: 1.1.1.50 Confidence Level: 0 AUTHORS: PMID:11454857 NOTES:
type: Reaction
reactant: MODEL1310110001#
product: MODEL1310110001#
name: RE1810
is: SBO:0000176
fast: false

metaR H2Oter
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
name: H2O endoplasmic reticulum transport
kinetic law: MODEL1310110001#

metaR HSPGtly
type: Reaction
product: MODEL1310110001#
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110001#
fast: false
name: heparan sulfate transport, extracellular to lysosome
is: SBO:0000185
kinetic law: MODEL1310110001#

metaR H2O2syn
name: Hydrogen peroxide synthesis (NADPH dependent)
is: SBO:0000176
notes: GENE_ASSOCIATION: (53905.1) or (50506.1) or (53905.2) SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15677770,PMID:15972824 NOTES:SAB lumped reaction--first O2 goes to superoxide radical, then dismutes to H2O2
product: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.6.3.1
reversible: false
is described by: ECO:0000304
type: Reaction
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_7f7cb4a2_8916_46cd_b73f_72301e7968e8
is encoded by: hsa:2194
is: SBO:0000252
is: P49327
boundary condition: true
has only substance units: false
constant: false
type: Species
initial amount: NaN
name: FASN
initial concentration: NaN

metaM atp m
type: Species
is: HMDB00538
is: CHEBI:57299
is: C00002
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
name: ATP(4-)

metaR FAOXC165C164x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:5-->C16:4)x
type: Reaction

metaM ksi deg12 l
name: keratan sulfate I, degradation product 12
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C174H279N12O153S9 CHARGE: -9
is: HMDB00143
has only substance units: false
initial amount: NaN
is: CHEBI:12936
boundary condition: false
is: SBO:0000247

metaM ksi deg1 e
is: CHEBI:17268
constant: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C241H383N17O209S12X CHARGE: -13
name: keratan sulfate I, degradation product 1
has only substance units: false
boundary condition: false
is: HMDB00211
type: Species

metaM gluside hs c
name: D-glucosyl-N-acylsphingosine
initial concentration: 1.0
type: Species
is: SBO:0000247
boundary condition: false
notes: FORMULA: C24H46NO7FULLRCO CHARGE: 0 EHMN_ABBREVIATION: C01190
is: CHEBI:18368
has only substance units: false
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_a43b5a36_747e_4ee6_8579_dfe384fc2b65
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: SBO:0000252
type: Species
name: RBKS
is encoded by: hsa:64080
constant: false
has only substance units: false
is: Q9H477

metaR EX 4abutn LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 4-ammoniobutanal
type: Reaction

metaR DOCO13ECOAtxc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 13-docosenoylcoa into peroxisomes
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_4ee6d393_1296_4f8b_8d9b_c96f4ef8daa3
initial amount: NaN
is encoded by: hsa:956
constant: false
initial concentration: NaN
has only substance units: false
name: ENTPD3
boundary condition: true
is: O75355
is: SBO:0000252
type: Species

metaM udpacgal g
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
type: Species
boundary condition: false
name: UDP-N-acetyl-D-galactosamine(2-)
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
is: CHEBI:57847
is: HMDB00304
initial concentration: 1.0

metaR RE2541E
is version of: http://identifiers.org/ec-code/3.2.1.31
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290 NOTES:
reversible: true
type: Reaction
name: RE2541
fast: false
is described by: ECO:0000000

metaM o2s c
is: CHEBI:18421
constant: false
initial amount: NaN
is: HMDB02168
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
has only substance units: false
is: SBO:0000247
name: superoxide

metaR TREHe
name: alpha,alpha-trehalase
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/3.2.1.28
type: Reaction
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (11181.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.28 Confidence Level: 4 AUTHORS: PMID:12065209,PMID:9427547 NOTES:JLR
fast: false
reversible: false
reactant: MODEL1310110001#
is: SBO:0000176

metaR VLCSp
modifier: MODEL1310110001#
name: Very-long-chain-fatty-acid-CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reversible: false
reactant: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 4 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
fast: false

metaR 5HTRPVESSEC
reactant: MODEL1310110001#
is described by: ECO:0000269
kinetic law: MODEL1310110001#
product: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (6570.1) or (6571.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12827358,PMID:15383652 NOTES:SAB This reaction represents the ATP driven secretion of 5htrp from the cell. It leaves out the vesicle because that is not a compartment. ATP:H ratio is assumed as 1:3 for vacuolar ATPase and substrate:h ratio is 1:2. This gives a 3:2 ratio for substrate:ATP
name: 5-hydroxy-L-tryptophan secretion via secretory vesicle (ATP driven)
reversible: false
modifier: MODEL1310110001#
is: SBO:0000185
type: Reaction

metaR ACOAD1fm
is version of: http://identifiers.org/ec-code/1.3.8.1
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110001#
fast: false
is described by: ECO:0000269
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (80724.1) or (36.1) or (35.1) or (34.1) or (84129.1) or (27034.1) or (28976.1) SUBSYSTEM: Butanoate metabolism EC Number: 1.3.99.2 Confidence Level: 4 AUTHORS: PMID:2565344 NOTES:Assume NAD/NADH as acceptors Lumped long-chain acyl-CoA dehydrogenase (EC 1.3.99.13) This reaction is therefore equilivalent to trans-2-enoyl-CoA reductase (NAD) (EC 1.3.1.44)
modifier: MODEL1310110001#
name: acyl-CoA dehydrogenase (butanoyl-CoA), mitochondrial
type: Reaction
is: SBO:0000176
reversible: false
reactant: MODEL1310110001#

metaR CYTK8
is: SBO:0000176
reversible: true
modifier: MODEL1310110001#
type: Reaction
name: cytidylate kinase (CMP,dATP)
is described by: ECO:0000269
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#

metaR LGNCCOAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
product: MODEL1310110001#
name: fatty acid intracellular transport
fast: false
is: SBO:0000185
kinetic law: MODEL1310110001#
reversible: true
type: Reaction
reactant: MODEL1310110001#

metaR IPDPtx
product: MODEL1310110001#
name: Isopentenyl diphosphate transport (peroxisome)
is: SBO:0000185
kinetic law: MODEL1310110001#
reversible: true
type: Reaction
is described by: ECO:0000134
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: 5.3.3.2 Confidence Level: 1 AUTHORS: PMID:11111079 NOTES:
reactant: MODEL1310110001#

metaR C60CPT1
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of hexanoylcarnitine
type: Reaction

metaR NACHEX13ly
is: SBO:0000176
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reactant: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.52
type: Reaction
reversible: false
name: beta-N-acetylhexosaminidase, lysosomal
modifier: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_d88ed071_c07d_459e_b06f_578bae493332
is encoded by: hsa:6487
name: ST3GAL3
initial amount: NaN
boundary condition: true
type: Species
is: Q5T4W8
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252

metaR PI45P4P
kinetic law: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:10358929 NOTES:NCD
product: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
is described by: ECO:0000000
reversible: false
name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase
is: SBO:0000176

metaR C181CRNt
name: C181 transport into the mitochondria
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reversible: false
is: SBO:0000185
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
modifier: MODEL1310110001#
product: MODEL1310110001#
fast: false
type: Reaction

metaM 4nph e
type: Species
name: 4-nitrophenolate
boundary condition: false
is: HMDB01232
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:57917
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_2dadf7b9_a78c_4df2_b993_45ab98243a80
name: _AI222095_1_m
constant: false
is encoded by: hsa:AI222095
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
initial amount: NaN

metaR EX leu L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Leucine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_ea495e6d_b0c5_45ba_a542_4e89e4359adb
has only substance units: false
is: SBO:0000252
is: Q9H6Y6
is encoded by: hsa:4645
boundary condition: true
constant: false
name: MYO5B
initial amount: NaN
type: Species
initial concentration: NaN

metaR CYTK9
is: SBO:0000176
is described by: ECO:0000269
name: cytidylate kinase (CMP,dCTP)
reactant: MODEL1310110001#
fast: false
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.14
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
modifier: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#

metaM dd2coa x
initial concentration: 1.0
constant: false
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01078 EHMN_ABBREVIATION: C03221
is: CHEBI:57330
is: SBO:0000247
is: HMDB03712
has only substance units: false
name: trans-Dodec-2-enoyl-CoA

metaM glx c
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: HMDB00119
notes: FORMULA: C2H1O3 CHARGE: -1 INCHI: InChI=1S/C2H2O3/c3-1-2(4)5/h1H,(H,4,5)/p-1 EHMN_ABBREVIATION: C00048
type: Species
is: CHEBI:36655
name: glyoxylate
initial amount: NaN
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_0897ffb6_5617_4216_8bd9_96a99965d812
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
name: GLA
has only substance units: false
is: Q53Y83
type: Species
is: SBO:0000252
is encoded by: hsa:2717

http://identifiers.org/biomodels.db/MODEL1310110001#_fc2544bd_33f9_405b_9753_aa0202c8dbdb
initial amount: NaN
is encoded by: hsa:7001
name: PRDX2
is: P32119
has only substance units: false
initial concentration: NaN
is: SBO:0000252
constant: false
boundary condition: true
type: Species

metaM tetdecdicoa x
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
initial amount: NaN
is: HMDB02288
has only substance units: false
name: 5,8-tetradecadienoylcoa
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR DUTPDPn
is: SBO:0000176
fast: false
is described by: ECO:0000269
name: dUTP diphosphatase, nuclear
modifier: MODEL1310110001#
reversible: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.6.1.23
notes: GENE_ASSOCIATION: (1854.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.23 Confidence Level: 4 AUTHORS: PMID:12799180,PMID:8631816,PMID:9070952 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_7436f1ab_a108_4993_ad23_3b2df55b341e
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:6561
boundary condition: true
name: SLC13A1
type: Species
is: Q9BZW2
is: SBO:0000252
has only substance units: false
constant: false

metaM xylt c
is: HMDB02917
name: xylitol
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
has only substance units: false
is: CHEBI:17151
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_0504ffc8_274a_4ba0_9dac_f9699ed7437d
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: C5HZ13
constant: false
is encoded by: hsa:1178
name: CLC
boundary condition: true

metaR TMNDNCCPT1
is described by: ECO:0000000
type: Reaction
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110001#
kinetic law: MODEL1310110001#
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ

metaR FAOXC102C103x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:2-->C10:3)x
type: Reaction

metaM forglu c
initial concentration: 1.0
constant: false
boundary condition: false
name: N-Formimidoyl-L-glutamate
is: HMDB00854
is: SBO:0000247
is: CHEBI:18327
type: Species
notes: FORMULA: C6H8N2O4 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00357 EHMN_ABBREVIATION: C00439
is: C00439
initial amount: NaN
has only substance units: false

metaR XYLTD Dr
type: Reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: xylitol dehydrogenase (D-xyulose-forming)
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.9 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:
is: SBO:0000176
fast: false
is described by: ECO:0000000
reversible: true

metaM o2s e
name: superoxide
constant: false
initial amount: NaN
is: HMDB02168
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: O2 CHARGE: -1 INCHI: InChI=1S/HO2/c1-2/h1H/p-1 HEPATONET_1.0_ABBREVIATION: HC00505 EHMN_ABBREVIATION: C00704
is: CHEBI:18421
has only substance units: false

metaM pram c
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB01128
is: CHEBI:58681
has only substance units: false
notes: FORMULA: C5H11NO7P CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01053 EHMN_ABBREVIATION: C03090
initial amount: NaN
constant: false
name: 5-Phospho-beta-D-ribosylamine
initial concentration: 1.0
is: C03090

metaM udpacgal c
boundary condition: false
notes: FORMULA: C17H25N3O17P2 CHARGE: -2 INCHI: InChI=1S/C17H27N3O17P2/c1-6(22)18-10-13(26)11(24)7(4-21)35-16(10)36-39(31,32)37-38(29,30)33-5-8-12(25)14(27)15(34-8)20-3-2-9(23)19-17(20)28/h2-3,7-8,10-16,21,24-27H,4-5H2,1H3,(H,18,22)(H,29,30)(H,31,32)(H,19,23,28)/p-2/t7-,8-,10-,11+,12-,13-,14-,15-,16?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00190 EHMN_ABBREVIATION: C00203
has only substance units: false
initial amount: NaN
is: CHEBI:57847
is: SBO:0000247
is: HMDB00304
constant: false
name: UDP-N-acetyl-D-galactosamine(2-)
type: Species
initial concentration: 1.0

metaM 35cgmp c
has only substance units: false
boundary condition: false
name: 3',5'-cyclic GMP(1-)
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
type: Species
is: HMDB01314
is: SBO:0000247
is: CHEBI:57746
constant: false

metaR H8TAer
reactant: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
fast: false
reversible: false
type: Reaction
is described by: ECO:0000000
name: H8 transamidase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (10026.1) and (8733.1) and (128869.1) and (94005.1) and (51604.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10727241,PMID:11483512,PMID:12802054,PMID:15632136,PMID:9356492,PMID:9468317 NOTES:EC 2.6.-.- NCD

metaR r1117
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:17124168 NOTES:
is described by: ECO:0000000
is: SBO:0000185
reversible: true
type: Reaction
product: MODEL1310110001#
kinetic law: MODEL1310110001#
name: Facilitated diffusion
reactant: MODEL1310110001#

metaR FADH2tru
is described by: ECO:0000000
fast: false
name: FADH2 transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110001#
type: Reaction
is: SBO:0000185
reactant: MODEL1310110001#
reversible: false
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_f00ecc23_254f_4f86_9fd9_4618655454fc
boundary condition: true
has only substance units: false
constant: false
initial amount: NaN
name: AK2
type: Species
is encoded by: hsa:204
initial concentration: NaN
is: SBO:0000252

metaM xoldiolone r
is: SBO:0000247
is: HMDB02197
boundary condition: false
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one
type: Species
notes: FORMULA: C27H44O3 CHARGE: 0 INCHI: InChI=1S/C27H44O3/c1-16(2)7-6-8-17(3)20-9-10-21-25-22(15-24(30)27(20,21)5)26(4)12-11-19(28)13-18(26)14-23(25)29/h13,16-17,20-25,29-30H,6-12,14-15H2,1-5H3/t17-,20-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01465 EHMN_ABBREVIATION: C05457
initial concentration: 1.0
initial amount: NaN
constant: false
is: CHEBI:28477
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_cf4040bc_91ca_4b3a_88fa_d12b0845028f
is: SBO:0000252
name: MTHFD1
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:4522
boundary condition: true
has only substance units: false
type: Species
is: P11586

http://identifiers.org/biomodels.db/MODEL1310110001#_d4115b0f_7627_44a0_a8ed_f3612a34ff87
type: Species
is encoded by: hsa:6342
is: C9JC79
is: SBO:0000252
boundary condition: true
name: SCP2
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_9dc81253_a063_4506_8e52_ed3f63e98cca
initial amount: NaN
is encoded by: hsa:53354
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
has only substance units: false
boundary condition: true
name: PANK1

metaR r0186
fast: false
reversible: false
type: Reaction
modifier: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000176
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 4.2.3.2 Confidence Level: 0 AUTHORS: PMID:5498429 NOTES:
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.2.1.5
name: Ethanolamine-phosphate phospho-lyase (deaminating) EC:4.2.3.2
product: MODEL1310110001#

metaR EX h2o LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: H2O exchange
type: Reaction

metaM 4nph c
is: CHEBI:57917
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C6H5NO3 CHARGE: 0 INCHI: InChI=1S/C6H5NO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H/p-1 HEPATONET_1.0_ABBREVIATION: HC00570 EHMN_ABBREVIATION: C00870
initial amount: NaN
is: SBO:0000247
name: 4-nitrophenolate
boundary condition: false
has only substance units: false
is: HMDB01232

metaM chsterol l
is: HMDB00067
initial concentration: 1.0
boundary condition: false
has only substance units: false
constant: false
is: SBO:0000247
is: CHEBI:16113
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial amount: NaN
name: cholesterol

metaR EX CE2838 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: maltononaose exchange
type: Reaction

metaM 4ppcys m
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C12H20N2O9PS CHARGE: -3 INCHI: InChI=1S/C12H23N2O9PS/c1-12(2,6-23-24(20,21)22)9(16)10(17)13-4-3-8(15)14-7(5-25)11(18)19/h7,9,16,25H,3-6H2,1-2H3,(H,13,17)(H,14,15)(H,18,19)(H2,20,21,22)/p-3/t7-,9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01276 EHMN_ABBREVIATION: C04352
is: SBO:0000247
name: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate(3-)
type: Species
constant: false
is: HMDB01117
is: CHEBI:59458
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_d1760d07_31d9_4eb4_8a25_3122eaa969c1
boundary condition: true
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
is encoded by: hsa:2592
is: SBO:0000252
name: GALT
has only substance units: false
is: B4E097

metaR TMNDNCCPT2
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
name: carnitine transferase
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
type: Reaction
reversible: false
fast: false

metaR DNDPt14m
fast: false
reversible: false
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
product: MODEL1310110001#
name: dUDP transport via dTDP antiport
type: Reaction
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000269
is: SBO:0000185

metaM 3hdcoa c
has only substance units: false
constant: false
name: (S)-3-Hydroxydecanoyl-CoA
notes: FORMULA: C31H50N7O18P3S CHARGE: -4
initial amount: NaN
boundary condition: false
type: Species
is: SBO:0000247
initial concentration: 1.0
is: HMDB00651

http://identifiers.org/biomodels.db/MODEL1310110001#_8b86250f_ed00_41cb_8bc0_7d06edb27184
initial amount: NaN
is: SBO:0000252
type: Species
initial concentration: NaN
boundary condition: true
is encoded by: hsa:26
name: ABP1
is: P19801
has only substance units: false
constant: false

metaR r1116
reversible: true
reactant: MODEL1310110001#
is described by: ECO:0000000
name: ATP Exporter (ATP-E) TCDB:9.A.6.1.1
fast: false
type: Reaction
is: SBO:0000185
product: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10913128,PMID:11147574,PMID:11557556,PMID:12269403,PMID:14613890,PMID:15210701,PMID:15958381,PMID:17124168,PMID:179827,PMID:18697206,PMID:3031070,PMID:3244197,PMID:9305892 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_2a6d0d5c_00df_49ab_ba22_e7516f99d6e8
has only substance units: false
is encoded by: hsa:145226
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: Q96NR8
is: SBO:0000252
name: RDH12

metaM xylt e
initial amount: NaN
is: SBO:0000247
name: xylitol
constant: false
has only substance units: false
is: HMDB02917
type: Species
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5+ HEPATONET_1.0_ABBREVIATION: HC00317 EHMN_ABBREVIATION: C00379
boundary condition: false
initial concentration: 1.0
is: CHEBI:17151

metaR FBP26
is version of: http://identifiers.org/ec-code/3.1.3.11
notes: GENE_ASSOCIATION: (2203.1) or (5210.1) or (5207.1) or (5209.1) or (5208.1) or (8789.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 3.1.3.46 Confidence Level: 0 AUTHORS: NOTES:IF
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.1.105
product: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
name: Fructose-2,6-bisphosphate 2-phosphatase
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
reversible: false
fast: false

metaR S6TASE26ly
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.6.14
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
product: MODEL1310110001#
name: N-acetylglucosamine-6-sulfatase, lysosomal
reversible: true
type: Reaction

metaM sphgn c
is: SBO:0000247
is: CHEBI:57817
constant: false
type: Species
is: HMDB00269
notes: FORMULA: C18H40NO2 CHARGE: 1 INCHI: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/p+1/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00556 EHMN_ABBREVIATION: C00836
initial concentration: 1.0
name: sphinganine(1+)
initial amount: NaN
boundary condition: false
has only substance units: false

metaR EX orn LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ornithine exchange
type: Reaction

metaR ELAIDCPT2
product: MODEL1310110001#
name: carnitine transferase
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
modifier: MODEL1310110001#
reversible: false
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.21
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_8979b4f5_b03d_488e_9499_6af6b7c316ee
initial concentration: NaN
is encoded by: hsa:AI378339
is: SBO:0000252
name: _AI378339_1_m
boundary condition: true
type: Species
initial amount: NaN
has only substance units: false
constant: false

metaM chsterol m
name: cholesterol
is: HMDB00067
initial concentration: 1.0
boundary condition: false
type: Species
notes: FORMULA: C27H46O CHARGE: 0 INCHI: InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00178 EHMN_ABBREVIATION: C00187
initial amount: NaN
is: CHEBI:16113
has only substance units: false
constant: false
is: SBO:0000247

metaM cl c
notes: FORMULA: Cl CHARGE: -1
is: SBO:0000247
is: CHEBI:3966
initial concentration: 1.0
name: Chloride
is: C00115
initial amount: NaN
constant: false
boundary condition: false
type: Species
has only substance units: false
is: HMDB00492

metaM HC00319 c
constant: false
is: SBO:0000247
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial concentration: 1.0
initial amount: NaN
name: Malonate
type: Species
has only substance units: false
boundary condition: false
is: CHEBI:30794

metaR NTP3e
type: Reaction
modifier: MODEL1310110001#
name: nucleoside-triphosphatase (GTP)
reactant: MODEL1310110001#
product: MODEL1310110001#
fast: false
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110001#
reversible: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.15 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
is version of: http://identifiers.org/ec-code/3.6.1.6

metaR r1661
reactant: MODEL1310110001#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
modifier: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_c7296c86_9642_476f_afbb_940aee4dbd2f
is: SBO:0000252
is: Q96QG2
has only substance units: false
name: SLC8A3
constant: false
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN
is encoded by: hsa:6547

metaR AG13T5g
modifier: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
kinetic law: MODEL1310110001#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.149
type: Reaction
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#

metaM CE4790 m
has only substance units: false
is: SBO:0000247
boundary condition: false
constant: false
notes: FORMULA: C35H56N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H60N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,21-24,28-30,34,43,46-47H,4-7,10-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-/t23-,24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE4790
name: (3S)-3-hydroxy-cis-8-tetradecenoyl-CoA
initial amount: NaN
type: Species
initial concentration: 1.0
is: CHEBI:57923

http://identifiers.org/biomodels.db/MODEL1310110001#_faf2aae0_8672_4e0f_ad11_16bfb97de6e0
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:10637
initial concentration: NaN
name: LEFTY1
has only substance units: false
is: SBO:0000252
boundary condition: true
is: O75610

metaR 4HPRO LTte
is: SBO:0000185
reactant: MODEL1310110001#
product: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110001#
is described by: ECO:0000134
type: Reaction
reversible: true
name: Transport of trans-4-hydroxy-L-proline

metaR r1662
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
is described by: ECO:0000000
product: MODEL1310110001#
modifier: MODEL1310110001#
reversible: true
type: Reaction
reactant: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_d40c677c_e405_45e8_b8b0_c0222a19a98b
type: Species
name: NME1:NME2
initial amount: NaN
is: SBO:0000297
constant: false
initial concentration: NaN
boundary condition: true
is encoded by: hsa:4830
is encoded by: hsa:4831
has only substance units: false
has part: P15531
has part: P22392

http://identifiers.org/biomodels.db/MODEL1310110001#_61584562_7593_444e_baae_f56a26e87991
initial amount: NaN
type: Species
constant: false
is: Q9UKG4
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: SLC13A4
is encoded by: hsa:26266
has only substance units: false

metaR EX thr L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Threonine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_0a1bb145_43f7_4f89_b0b2_97adeffddc42
is: SBO:0000252
initial concentration: NaN
constant: false
is encoded by: hsa:79053
type: Species
boundary condition: true
name: ALG8
has only substance units: false
initial amount: NaN

metaM lpchol hs e
type: Species
name: lysophosphatidylcholine
constant: false
is: CHEBI:60479
has only substance units: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
is: SBO:0000247
boundary condition: false

metaM 4mptnl c
initial amount: NaN
is: CHEBI:17998
name: 4-methylpentanal
constant: false
initial concentration: 1.0
type: Species
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
boundary condition: false
has only substance units: false
is: SBO:0000247
is: HMDB01318

metaR C142ACBP
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 3-hydroxytetradeca dienoyl coa from mitochondria into cytosol
type: Reaction

metaR PROSTGE2t
fast: false
notes: GENE_ASSOCIATION: (28231.1) or (6578.1) or (28232.1) or (6579.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
modifier: MODEL1310110001#
type: Reaction
name: prostaglandin transport via bicarbonate countertransport
is: SBO:0000185
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: true
is described by: ECO:0000269
kinetic law: MODEL1310110001#

metaR 5MTHFt2le
fast: false
is described by: ECO:0000134
name: 5-methyltetrahydrofolate transport via anion exchange
is: SBO:0000185
reactant: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110001#
type: Reaction

metaM cl e
name: Chloride
constant: false
is: CHEBI:3966
type: Species
initial amount: NaN
is: HMDB00492
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
notes: FORMULA: Cl CHARGE: -1
is: C00115

metaR DGK1
is described by: ECO:0000269
reversible: true
modifier: MODEL1310110001#
is: SBO:0000176
fast: false
type: Reaction
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.8
name: deoxyguanylate kinase (dGMP:ATP)
notes: GENE_ASSOCIATION: (2987.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110001#

metaR EX ptrc LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 1,4-butanediammonium
type: Reaction

metaR FAOXC142C122m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:2-->C12:2)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_5f0857e0_6d99_4809_bb72_6312792e7f3c
boundary condition: true
is encoded by: hsa:341947
initial amount: NaN
constant: false
name: COX8C
has only substance units: false
is: SBO:0000252
type: Species
is: Q7Z4L0
initial concentration: NaN

metaM 2octdectecoa x
is: SBO:0000247
boundary condition: false
is: http://identifiers.org/pubchem.compound/5280355
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
constant: false
name: 2,6,9,12-octadecatetraenoylcoa
initial concentration: 1.0
has only substance units: false

metaR FAOXC227C226m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:7-->C22:6)m
type: Reaction

metaR PROSTGD2t
notes: GENE_ASSOCIATION: (6578.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12507753,PMID:8787677,PMID:9334206 NOTES:NJ
is: SBO:0000185
is described by: ECO:0000269
type: Reaction
fast: false
reversible: true
reactant: MODEL1310110001#
name: prostaglandin transport via bicarbonate countertransport
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_4db7f9aa_7653_4074_8e77_8ea1027c89f8
initial concentration: NaN
is: SBO:0000252
initial amount: NaN
constant: false
has only substance units: false
is encoded by: hsa:7371
name: UCK2
type: Species
boundary condition: true
is: Q9BZX2

http://identifiers.org/biomodels.db/MODEL1310110001#_6859ccae_19e6_43d6_bfae_7ed6da6d9eab
initial amount: NaN
initial concentration: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:3038
type: Species
is: SBO:0000252
is: O00219
name: HAS3
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_7725765d_4fe1_4026_a7e1_e1873a5268a7
initial concentration: NaN
is encoded by: hsa:11041
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
name: B3GNT1
has only substance units: false
is: O43505
boundary condition: true

metaR r1660
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110001#
product: MODEL1310110001#
reversible: true
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR SBTR
reversible: false
kinetic law: MODEL1310110001#
is described by: ECO:0000269
name: D-sorbitol reductase
is: SBO:0000176
fast: false
type: Reaction
reactant: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (8574.1) or (10327.1) or (231.1) or (10327.2) SUBSYSTEM: Fructose and mannose metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:9823300 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.2
is version of: http://identifiers.org/ec-code/1.1.1.21

http://identifiers.org/biomodels.db/MODEL1310110001#_518faa5f_92b9_4c15_ad23_f18683297dc3
is: SBO:0000252
type: Species
name: _AA177072_1_x
is encoded by: hsa:AA177072
initial amount: NaN
initial concentration: NaN
constant: false
has only substance units: false
boundary condition: true

metaM hdcecrn c
initial amount: NaN
constant: false
name: Hexadecenoyl carnitine
type: Species
is: HMDB00222
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C23H43NO4 CHARGE: 0 INCHI: InChI=1/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
has only substance units: false
boundary condition: false

metaM lpchol hs c
name: lysophosphatidylcholine
type: Species
has only substance units: false
is: CHEBI:60479
constant: false
initial concentration: 1.0
notes: FORMULA: C8H19NO5PFULLRCO2 CHARGE: 0
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaM c6dc x
is: C14143
initial concentration: 1.0
has only substance units: false
name: adipoyl carnitine
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
boundary condition: false
notes: FORMULA: C13H22NO6 CHARGE: -1
is: HMDB04047

metaR OMPDC
is version of: http://identifiers.org/ec-code/2.4.2.10
is described by: ECO:0000269
reversible: false
type: Reaction
is: SBO:0000176
name: orotidine-5'-phosphate decarboxylase
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 4.1.1.23 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
fast: false

metaM 4mptnl e
initial amount: NaN
constant: false
is: CHEBI:17998
type: Species
initial concentration: 1.0
is: SBO:0000247
is: HMDB01318
name: 4-methylpentanal
notes: FORMULA: C6H12O CHARGE: 0 INCHI: InChI=1S/C6H12O/c1-6(2)4-3-5-7/h5-6H,3-4H2,1-2H3 EHMN_ABBREVIATION: C02373
boundary condition: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_67051ea6_92d7_456e_bde7_0b3b8c326b2b
constant: false
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:3242
boundary condition: true
initial amount: NaN
has only substance units: false
is: B3KQ63
name: HPD

metaR OCT11EFATP
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of vaccenic acid by cells
type: Reaction

metaM HC01609 e
boundary condition: false
is: CHEBI:28766
initial amount: NaN
has only substance units: false
type: Species
constant: false
name: UroporphyrinogenI
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C40H36N4O16 CHARGE: -8 INCHI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60) EHMN_ABBREVIATION: C05766

metaR ECOAH12m
fast: false
reactant: MODEL1310110001#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (1892.1) or (3030.1) and (3032.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 2 AUTHORS: PMID:9073515 NOTES:MM. based on assigned short chain enoyl-CoA hydratase activity
is: SBO:0000176
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.2.1.17
type: Reaction
product: MODEL1310110001#
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxyisobutyryl-CoA) (mitochondria)

metaR FUCASEe
name: alpha-fucosidase, extracellular
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (2519.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.51 Confidence Level: 0 AUTHORS: NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/3.2.1.51
kinetic law: MODEL1310110001#
reversible: false

metaR ACONT
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
name: aconitase
notes: GENE_ASSOCIATION: (3658.1) or (48.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.3 Confidence Level: 0 AUTHORS: PMID:10419470,PMID:17244191,PMID:17244192 NOTES:SMP. Biochemical
is version of: http://identifiers.org/ec-code/4.2.1.3
reactant: MODEL1310110001#
is described by: ECO:0000134
fast: false
reversible: true
product: MODEL1310110001#
is: SBO:0000176

metaR FAOXC4C4DCc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: succ-->C4DCc
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_32dddcb1_74f4_41af_b930_23aeb27025d9
type: Species
constant: false
name: CHAT
is: Q6LEN6
has only substance units: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:1103

http://identifiers.org/biomodels.db/MODEL1310110001#_ebd5f697_0e3c_4a56_a65a_2b62c6bdbd8e
name: PKLR
is encoded by: hsa:5313
boundary condition: true
is: SBO:0000252
is: P30613
type: Species
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN

metaR r1665
modifier: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
is: SBO:0000185
fast: false
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_d35cbeee_54c2_4f13_85a2_a5a83db1c2bf
has only substance units: false
name: SLC25A10
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
constant: false
is: Q9UBX3
is encoded by: hsa:1468
initial concentration: NaN

metaM retn r
has only substance units: false
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
name: all-trans-retinoate
is: HMDB01852
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:35291
boundary condition: false

metaM CE5161 r
name: 3(S)-hydroxy-cis-9-octadecenoyl-CoA
is: CHEBI:57923
has only substance units: false
type: Species
is: SBO:0000247
notes: FORMULA: C39H64N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H68N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-28,32-34,38,47,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t27-,28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5161
boundary condition: false
constant: false
initial concentration: 1.0
initial amount: NaN

metaM etha c
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000247
name: etha[c]
initial concentration: 1.0
is: HMDB00149
notes: FORMULA: C2H8NO CHARGE: 1 INCHI: InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00180 EHMN_ABBREVIATION: C00189
boundary condition: false
is: CHEBI:57603
constant: false

metaR FAOXC164m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)m
type: Reaction

metaR r2200
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is: SBO:0000185
product: MODEL1310110001#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5

http://identifiers.org/biomodels.db/MODEL1310110001#_7bbdcc82_1772_41c0_aeb0_4510f0537e20
is: GO:0005634
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: nucleus
type: Compartment

metaR DURIK1
is version of: http://identifiers.org/ec-code/2.7.1.21
modifier: MODEL1310110001#
reversible: false
reactant: MODEL1310110001#
fast: false
name: deoxyuridine kinase (ATP:Deoxyuridine)
kinetic law: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
is: SBO:0000176
is described by: ECO:0000254
notes: GENE_ASSOCIATION: (7083.1) or (7084.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.21 Confidence Level: 2 AUTHORS: PMID:12535661,PMID:9342341 NOTES:

metaM CE2424 m
constant: false
notes: FORMULA: C35H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C35H56N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-23(43)18-26(45)64-17-16-37-25(44)14-15-38-33(48)30(47)35(2,3)20-57-63(54,55)60-62(52,53)56-19-24-29(59-61(49,50)51)28(46)34(58-24)42-22-41-27-31(36)39-21-40-32(27)42/h8-9,11-12,21-22,24,28-30,34,46-47H,4-7,10,13-20H2,1-3H3,(H,37,44)(H,38,48)(H,52,53)(H,54,55)(H2,36,39,40)(H2,49,50,51)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE2424
boundary condition: false
name: 3-oxo-cis,cis-5,8-tetradecadienoyl-CoA
type: Species
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:28387
is: HMDB11123

metaR TXASr
name: Thromboxane-A synthase
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (6916.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 5.3.99.5 Confidence Level: 0 AUTHORS: PMID:10903770,PMID:2491846,PMID:7811713 NOTES:NJ
reversible: false
is version of: http://identifiers.org/ec-code/5.3.99.5
type: Reaction
is described by: ECO:0000134
kinetic law: MODEL1310110001#
product: MODEL1310110001#
fast: false
is: SBO:0000176
reactant: MODEL1310110001#

metaR M13N2Tg
is version of: http://identifiers.org/ec-code/2.4.1.101
reactant: MODEL1310110001#
product: MODEL1310110001#
name: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
reversible: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (4245.1) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.101 Confidence Level: 0 AUTHORS: PMID:12621063 NOTES:NCD
is: SBO:0000176
modifier: MODEL1310110001#
type: Reaction
fast: false
kinetic law: MODEL1310110001#

metaR EX prostgf2 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Prostaglandin F2alpha exchange
type: Reaction

metaM atp r
constant: false
boundary condition: false
name: ATP(4-)
is: SBO:0000247
type: Species
is: HMDB00538
has only substance units: false
initial amount: NaN
is: CHEBI:57299
is: C00002
initial concentration: 1.0

metaR r1666
kinetic law: MODEL1310110001#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
reactant: MODEL1310110001#
is: SBO:0000185
fast: false
reversible: true
product: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM lac L e
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: SBO:0000247
constant: false
initial amount: NaN
is: HMDB00190
has only substance units: false
initial concentration: 1.0
type: Species
name: (S)-lactate
boundary condition: false
is: CHEBI:16651

metaM dmnoncoa m
type: Species
initial concentration: 1.0
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
constant: false
initial amount: NaN
is: SBO:0000247
name: 4,8 dimethylnonanoyl-CoA
boundary condition: false
has only substance units: false
is: HMDB11604

metaR r2201
product: MODEL1310110001#
modifier: MODEL1310110001#
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
kinetic law: MODEL1310110001#
fast: false
is described by: ECO:0000000
reversible: true
is: SBO:0000185
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_cbbd6f5a_d047_45ba_8681_8ae80385e52f
initial amount: NaN
boundary condition: true
name: PIGC
is encoded by: hsa:5279
is: SBO:0000252
initial concentration: NaN
type: Species
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_26c3338d_ba95_42bb_9e31_00579ef83b5f
initial amount: NaN
type: Species
is: D6RDW3
is encoded by: hsa:2982
name: GUCY1A3
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false

metaR OCCOAtm
is: SBO:0000185
is described by: ECO:0000000
reversible: false
product: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
name: Octanoyl-CoA transport, diffusion
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:TDV

http://identifiers.org/biomodels.db/MODEL1310110001#_c1a29b08_45b1_425c_9200_b209cd65740e
is: GO:0005739
is: SBO:0000290
constant: false
size: 1.0
spatial dimensions: 3.0
name: mitochondrion
type: Compartment

http://identifiers.org/biomodels.db/MODEL1310110001#_86f0ba4a_1017_4f27_a69f_8e07d5f2691f
boundary condition: true
constant: false
is encoded by: hsa:642502
is: SBO:0000252
type: Species
initial amount: NaN
has only substance units: false
name: _642502_1_c
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_f24066df_26b5_411e_abe8_7df18d0098a2
boundary condition: true
has only substance units: false
type: Species
initial concentration: NaN
constant: false
has part: A7E2E0
has part: Q92569
is: SBO:0000297
initial amount: NaN
is encoded by: hsa:8503
is encoded by: hsa:5293
name: PIK3CD:PIK3R3

http://identifiers.org/biomodels.db/MODEL1310110001#_4d95b291_a60c_4ab0_afe1_aa5f5a4a7f69
has only substance units: false
is: SBO:0000252
boundary condition: true
name: ALG12
is: Q9BV10
initial amount: NaN
is encoded by: hsa:79087
initial concentration: NaN
type: Species
constant: false

metaR r0181
notes: GENE_ASSOCIATION: (AA081045.1) or (AI620219.1) or (220.1) or (219.1) or (217.1) or (218.1) or (224.1) or (221.1) or (222.1) or (501.1) or (223.1) or (AU149534.1) or (T83654.1) or (U37519.1) SUBSYSTEM: Purine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
fast: false
is described by: ECO:0000000
name: ITP diphosphohydrolase Purine metabolism EC:3.6.1.5
is: SBO:0000176
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
reversible: true
modifier: MODEL1310110001#

metaM glyclt x
boundary condition: false
notes: FORMULA: C2H3O3 CHARGE: -1 INCHI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)/p-1 EHMN_ABBREVIATION: C00160
name: glycolate
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:29805
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: HMDB00115

metaR Coqe
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110001#
product: MODEL1310110001#
name: Transport of q10
fast: false
kinetic law: MODEL1310110001#
type: Reaction
is: SBO:0000185
is described by: ECO:0000134
reversible: true

metaR EX lys L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lysine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_49fe5c51_a2ab_49ee_b030_009f26440a89
is: SBO:0000297
boundary condition: true
is encoded by: hsa:8802
has part: Q96I99
has only substance units: false
initial concentration: NaN
constant: false
is encoded by: hsa:8801
has part: P53597
initial amount: NaN
type: Species
name: SUCLG2:SUCLG1

metaR SBCOAACOTx
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of suberyl coa for release into cytosol
type: Reaction

metaM ksii core2 pre1 g
notes: FORMULA: C33H53N3O23X CHARGE: -1
initial concentration: 1.0
has only substance units: false
type: Species
boundary condition: false
name: keratan sulfate II biosynthesis, precursor 1
constant: false
is: CHEBI:28067
is: SBO:0000247
initial amount: NaN

metaM m6mpdol L r
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
notes: FORMULA: C1660H2728N20O520P20 CHARGE: -20
has only substance units: false
initial amount: NaN
is: SBO:0000247
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:37635

metaR r2202
name: Resistance-Nodulation-Cell Division (RND) TCDB:2.A.60.1.5
reversible: true
fast: false
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11076394,PMID:11076396,PMID:14579113 NOTES:
is described by: ECO:0000000
product: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction

metaR r1664
fast: false
modifier: MODEL1310110001#
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110001#
name: Y+LAT2 Utilized transport
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM 35cgmp n
boundary condition: false
is: HMDB01314
initial concentration: 1.0
constant: false
notes: FORMULA: C10H11N5O7P CHARGE: -1 INCHI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/p-1/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00592 EHMN_ABBREVIATION: C00942
is: CHEBI:57746
is: SBO:0000247
name: 3',5'-cyclic GMP(1-)
has only substance units: false
initial amount: NaN
type: Species

metaR MTHFD2m
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.5.4.9
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
type: Reaction
fast: false
reactant: MODEL1310110001#
modifier: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (10797.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.5 Confidence Level: 2 AUTHORS: PMID:8218174 NOTES:NCD
is described by: ECO:0000254

http://identifiers.org/biomodels.db/MODEL1310110001#_d861530a_070b_4ae7_bd33_126fa1f02085
has only substance units: false
constant: false
initial concentration: NaN
type: Species
boundary condition: true
name: SLC38A1
is: Q9H2H9
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:81539

http://identifiers.org/biomodels.db/MODEL1310110001#_7950f81e_1d6e_4f78_a109_844621e986e4
is: O76074
has only substance units: false
boundary condition: true
name: PDE5A
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:8654
is: SBO:0000252
initial concentration: NaN

metaR CYTK5n
product: MODEL1310110001#
fast: false
type: Reaction
is described by: ECO:0000269
is: SBO:0000176
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.14
modifier: MODEL1310110001#
name: cytidylate kinase (CMP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544 NOTES:
reversible: true

metaM m7masnB g
has only substance units: false
constant: false
boundary condition: false
type: Species
is: C04946
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C64H107N2O50X CHARGE: 0
initial concentration: 1.0
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)

http://identifiers.org/biomodels.db/MODEL1310110001#_474d112d_e7b8_41af_98fc_7d9564c19e9d
initial amount: NaN
has only substance units: false
is encoded by: hsa:57835
initial concentration: NaN
constant: false
type: Species
is: SBO:0000252
boundary condition: true
name: SLC4A5

http://identifiers.org/biomodels.db/MODEL1310110001#_92180422_caee_48e7_bd10_0f2a48263c9a
initial concentration: NaN
boundary condition: true
constant: false
type: Species
has only substance units: false
is encoded by: hsa:219
is: P30837
initial amount: NaN
name: ALDH1B1
is: SBO:0000252

metaM lac L c
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00190
initial amount: NaN
initial concentration: 1.0
type: Species
name: (S)-lactate
boundary condition: false
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
is: CHEBI:16651

metaR EX hdcea LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Hexadecenoate (n-C16:1)
type: Reaction

metaR UPP3S
reactant: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (7390.1) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.75 Confidence Level: 0 AUTHORS: PMID:3174619 NOTES:
is: SBO:0000176
modifier: MODEL1310110001#
name: uroporphyrinogen-III synthase
is version of: http://identifiers.org/ec-code/4.2.1.75
type: Reaction
fast: false
reversible: false
is described by: ECO:0000000

metaM hexdiac r
type: Species
is: C08260
is: SBO:0000247
notes: FORMULA: C16H28O4 CHARGE: -2
constant: false
initial amount: NaN
boundary condition: false
initial concentration: 1.0
has only substance units: false
is: HMDB00672
name: hexadecanediocacid

metaR r1556
is: SBO:0000185
reactant: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110001#
fast: false
reversible: true
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR NACHEX10ly
modifier: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.52
is: SBO:0000176
type: Reaction
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_de395a38_c770_4fcc_877b_8a14e2203f43
name: SLC2A4
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false
is: P14672
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:6517

http://identifiers.org/biomodels.db/MODEL1310110001#_d4ebf049_10a3_473e_8d74_9d687e515ddc
name: ATP5G2
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
constant: false
is encoded by: hsa:517
type: Species

metaR PGI
is described by: ECO:0000134
reversible: true
kinetic law: MODEL1310110001#
name: glucose-6-phosphate isomerase
type: Reaction
is version of: http://identifiers.org/ec-code/5.3.1.9
reactant: MODEL1310110001#
product: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (2821.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.9 Confidence Level: 0 AUTHORS: PMID:19064002,PMID:2241164,PMID:8530082 NOTES:

metaR C226CRNt
kinetic law: MODEL1310110001#
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
is: SBO:0000185
reactant: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#
name: C226 transport into the mitochondria

metaR ABTti
reactant: MODEL1310110001#
reversible: false
product: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:15234337 NOTES:NCD
name: L-arabinitol transport via passive diffusion
kinetic law: MODEL1310110001#

metaM thexddcoa m
initial amount: NaN
type: Species
is: HMDB02288
boundary condition: false
has only substance units: false
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C37H58N7O17P3S CHARGE: -4
constant: false
name: trans7,10-hexadecadienoylcoa

http://identifiers.org/biomodels.db/MODEL1310110001#_6da670c7_8bdd_4563_871e_fc39e264618c
name: AADAT
type: Species
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: Q4W5N8
is: SBO:0000252
boundary condition: true
constant: false
is encoded by: hsa:51166

metaM CE4872 c
type: Species
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
is: HMDB00127
is: CHEBI:15748
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_619e2b2b_b8ca_4b19_984a_0a40b4d7896e
initial amount: NaN
boundary condition: true
has only substance units: false
is: Q99807
initial concentration: NaN
constant: false
type: Species
name: COQ7
is encoded by: hsa:10229
is: SBO:0000252

metaR r1557
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000185
reversible: true

metaM CE0785 m
initial concentration: 1.0
is: CHEBI:57795
initial amount: NaN
is: SBO:0000247
boundary condition: false
name: cis,cis-myristo-5,8-dienoyl-CoA
has only substance units: false
type: Species
constant: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C35H58N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-26(44)63-19-18-37-25(43)16-17-38-33(47)30(46)35(2,3)21-56-62(53,54)59-61(51,52)55-20-24-29(58-60(48,49)50)28(45)34(57-24)42-23-41-27-31(36)39-22-40-32(27)42/h8-9,11-12,22-24,28-30,34,45-46H,4-7,10,13-21H2,1-3H3,(H,37,43)(H,38,47)(H,51,52)(H,53,54)(H2,36,39,40)(H2,48,49,50)/p-4/b9-8-,12-11-/t24-,28+,29+,30u,34-/m0/s1 EHMN_ABBREVIATION: CE0785

metaM eicostet e
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1
is: HMDB02177
initial concentration: 1.0
name: eicosatetranoic acid
is: SBO:0000247
boundary condition: false
initial amount: NaN
has only substance units: false
is: CHEBI:36033
type: Species

metaR 5HOXINDACTO2OX
product: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.2.3.1
is: SBO:0000176
fast: false
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (316.1) SUBSYSTEM: Tryptophan metabolism EC Number: 1.2.3.1 Confidence Level: 2 AUTHORS: PMID:11306106 NOTES:SAB questionable--balanced, but h2o2 production is based on an obscure comment in entrez
kinetic law: MODEL1310110001#
is described by: ECO:0000304
reactant: MODEL1310110001#
name: 5-Hydroxyindoleacetaldehyde:oxygen oxidoreductase

metaR CORE2GTg
fast: false
reversible: false
notes: GENE_ASSOCIATION: (9245.1) or (2650.1) or (51301.1) SUBSYSTEM: O-glycan synthesis EC Number: 2.4.1.102 Confidence Level: 0 AUTHORS: PMID:10753916,PMID:9915862 NOTES:NCD
product: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
is: SBO:0000176
name: Core 2 acetylglucosaminyltransferase, Golgi apparatus
is version of: http://identifiers.org/ec-code/2.4.1.102

http://identifiers.org/biomodels.db/MODEL1310110001#_0872493f_22bc_4a0b_a69f_b0682531172e
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:277
type: Species
has only substance units: false
name: AMY1B
initial amount: NaN
is: SBO:0000252
is: P04745

metaM glu5sa m
is: C01165
is: CHEBI:17232
boundary condition: false
constant: false
initial amount: NaN
name: L-Glutamate 5-semialdehyde
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C5H9NO3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00694 EHMN_ABBREVIATION: C01165
is: SBO:0000247
is: HMDB02104
type: Species

metaR r2519
product: MODEL1310110001#
fast: false
name: Utilized transport
type: Reaction
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:16611737,PMID:18307097 NOTES:
kinetic law: MODEL1310110001#

metaR RPEc
is: SBO:0000176
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000134
name: ribulose 5-phosphate 3-epimerase
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 5.1.3.1 Confidence Level: 4 AUTHORS: PMID: 4382012, PMID: 13575411, Harpers illustrated Biochemistry (2009) 28th edition pages 174-183 NOTES:coefficient changed to 2
reversible: true

metaM ttetddcoa m
initial concentration: 1.0
type: Species
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB02288
boundary condition: false
notes: FORMULA: C35H54N7O17P3S CHARGE: -4
name: trans5,8tetradecadienoylcoa
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_bb6ed1ce_6936_4c1d_ae45_23021693f4e8
is: SBO:0000252
constant: false
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
is: O14975
name: SLC27A2
is encoded by: hsa:11001

metaR EX CE5788 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: kinetensin 1-7 exchange
type: Reaction

metaR PRO1xm
name: proline oxidase (NAD), mitochondrial
reversible: false
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.5.99.8
kinetic law: MODEL1310110001#
is described by: ECO:0000254
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:NCD
product: MODEL1310110001#
type: Reaction

metaR CSPG Atly
reactant: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#
fast: false
name: chondroitin sulfate A transport, extracellular to lysosome
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
reversible: false
is: SBO:0000185
kinetic law: MODEL1310110001#

metaR C3DCe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of malonyl carnitine into extra cellular space
type: Reaction

metaR EX tetpent6 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange
type: Reaction

metaR OCD11CRNCACT
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of 11-octadecenoyl carnitine into the mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_85141ee5_3790_4045_8085_afd4b3d67651
initial amount: NaN
constant: false
is: Q9Y345
initial concentration: NaN
type: Species
name: SLC6A5
has only substance units: false
is encoded by: hsa:9152
is: SBO:0000252
boundary condition: true

metaM dodecanac x
is: HMDB00623
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
name: Dodecanedioic acid
initial amount: NaN
type: Species
initial concentration: 1.0
notes: FORMULA: C12H20O4 CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110001#_4ce7ea93_b735_45a4_bb1d_59add121ff93
initial amount: NaN
is encoded by: hsa:8897
has only substance units: false
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: MTMR3

http://identifiers.org/biomodels.db/MODEL1310110001#_e58de247_0c11_4140_a34c_d771bc339b76
has part: A3KLL5
has only substance units: false
type: Species
constant: false
is encoded by: hsa:478
initial concentration: NaN
is encoded by: hsa:481
initial amount: NaN
name: ATP1A3:ATP1B1
boundary condition: true
is: SBO:0000297
has part: B7Z2T0

metaM xtsn c
is: SBO:0000247
name: xanthosine
notes: FORMULA: C10H12N4O6 CHARGE: 0 INCHI: InChI=1S/C10H12N4O6/c15-1-3-5(16)6(17)9(20-3)14-2-11-4-7(14)12-10(19)13-8(4)18/h2-3,5-6,9,15-17H,1H2,(H2,12,13,18,19)/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00838 EHMN_ABBREVIATION: C01762
has only substance units: false
constant: false
initial amount: NaN
type: Species
is: HMDB00299
is: CHEBI:18107
initial concentration: 1.0
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_79b4ef2c_7fd5_4b87_aae1_affaf2d8701f
name: PDE8A
is encoded by: hsa:5151
is: SBO:0000252
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_7335701f_f8c2_460c_99ff_0952d80be6f0
has only substance units: false
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: PPCDC
boundary condition: true
is encoded by: hsa:60490
is: Q96CD2
type: Species

metaM dd2coa c
notes: FORMULA: C33H52N7O17P3S CHARGE: -4
name: trans-Dodec-2-enoyl-CoA
initial amount: NaN
has only substance units: false
constant: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247
is: HMDB03712

metaR r1554
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110001#
type: Reaction

metaM m4mpdol U c
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
constant: false
is: CHEBI:37633
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
initial amount: NaN
initial concentration: 1.0
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog

metaM C05279 m
constant: false
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
type: Species
notes: FORMULA: C33H50N7O17P3S CHARGE: -4 INCHI: InChI=1S/C33H54N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,12-13,20-22,26-28,32,43-44H,4-7,10-11,14-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/b9-8-,13-12+/t22-,26-,27-,28+,32-/m1/s1 EHMN_ABBREVIATION: C05279
is: CHEBI:28387
is: HMDB11123
has only substance units: false
boundary condition: false
name: trans,cis-Lauro-2,6-dienoyl-CoA

metaM eicostet c
type: Species
name: eicosatetranoic acid
initial concentration: 1.0
constant: false
is: HMDB02177
boundary condition: false
has only substance units: false
is: SBO:0000247
initial amount: NaN
is: CHEBI:36033
notes: FORMULA: C20H31O2 CHARGE: -1

metaR FAOXC164x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:4)x
type: Reaction

metaR EX tsul LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiosulfate exchange
type: Reaction

metaR ARABR
reversible: false
fast: false
type: Reaction
product: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:12359133,PMID:15234337,PMID:9823300 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.2
is: SBO:0000176
name: arabinose reductase
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.21

metaM gluala e
name: 5-L-Glutamyl-L-alanine
is: SBO:0000247
has only substance units: false
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/6503
is: C03740
is: HMDB06248
notes: FORMULA: C8H13N2O5 CHARGE: -1 INCHI: InChI=1/C8H14N2O5/c1-4(7(12)13)10-6(11)3-2-5(9)8(14)15/h4-5H,2-3,9H2,1H3,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1 EHMN_ABBREVIATION: C03740
constant: false
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_5225254e_3967_46e1_aa6c_1ba01b1f31db
is encoded by: hsa:50
is: Q99798
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
boundary condition: true
name: ACO2
has only substance units: false
is: SBO:0000252

metaR EX arab L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arabinose exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_caf2a0a0_7a64_47a2_8b2d_56671ff9ccb5
has only substance units: false
is: SBO:0000252
initial concentration: NaN
is: Q6TCH8
boundary condition: true
initial amount: NaN
is encoded by: hsa:10873
type: Species
name: ME3
constant: false

metaM drib c
is: HMDB03224
has only substance units: false
is: CHEBI:28816
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
type: Species
boundary condition: false
name: 2-deoxy-D-ribose
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247

metaM ksii core4 pre9 g
name: keratan sulfate II biosynthesis, precursor 9
has only substance units: false
initial concentration: 1.0
is: CHEBI:28067
boundary condition: false
notes: FORMULA: C83H133N7O64S2X CHARGE: -3
is: SBO:0000247
constant: false
type: Species
initial amount: NaN

metaR r1552
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
type: Reaction
is: SBO:0000185
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110001#

metaR r2514
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
name: Utilized transport
type: Reaction
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_1f7beb12_2e1b_4a10_a1bb_ae9a8d88ec07
has only substance units: false
is: Q9C0J1
is: SBO:0000252
boundary condition: true
is encoded by: hsa:79369
type: Species
initial amount: NaN
constant: false
name: B3GNT4
initial concentration: NaN

metaR RE1135C
is version of: http://identifiers.org/ec-code/3.1.6.2
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (412.1) SUBSYSTEM: Steroid metabolism EC Number: 3.1.6.2 Confidence Level: 0 AUTHORS: PMID:10049998,PMID:1606923 NOTES:
reactant: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
name: RE1135
modifier: MODEL1310110001#
is: SBO:0000176
type: Reaction
fast: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_8ea6275c_b860_456a_89eb_e58ba2b9b0bb
boundary condition: true
name: LDHB
has only substance units: false
is encoded by: hsa:3945
is: P07195
initial concentration: NaN
type: Species
constant: false
initial amount: NaN
is: SBO:0000252

metaM pristcoa x
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
is: CHEBI:51341
type: Species
has only substance units: false
initial amount: NaN
name: pristanoyl coa
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
constant: false

metaM tetpent3coa c
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
has only substance units: false
type: Species
initial amount: NaN
name: tetracosapentaenoyl coenzyme A, n-3
constant: false
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h5-6,8-9,11-12,14-15,17-18,32-34,38-40,44,55-56H,4,7,10,13,16,19-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b6-5-,9-8-,12-11-,15-14-,18-17-/t34-,38-,39-,40?,44-/m1/s1
is: C16167

metaM cdpea c
name: cdpea[c]
type: Species
initial amount: NaN
constant: false
notes: FORMULA: C11H19N4O11P2 CHARGE: -1 INCHI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/p-1/t6-,8-,9-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00433 EHMN_ABBREVIATION: C00570
is: SBO:0000247
is: CHEBI:57876
is: HMDB01564
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR RE2269E
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.4.21.39
product: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000176
fast: false
name: RE2269
modifier: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (1215.1) SUBSYSTEM: Miscellaneous EC Number: 3.4.21.39 Confidence Level: 0 AUTHORS: PMID:1800960 NOTES:
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_8522aed9_75ad_4b68_a191_3a6a74193fc0
has only substance units: false
constant: false
is: Q9NSW9
boundary condition: true
type: Species
name: SLC9A5
is encoded by: hsa:6553
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_5c6e0ace_d419_4c28_abb8_6bc5ef96e41c
boundary condition: true
has only substance units: false
is: O75387
name: SLC43A1
constant: false
type: Species
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:8501
initial concentration: NaN

metaR r1553
reactant: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
type: Reaction
product: MODEL1310110001#
fast: false

metaR EX tetdec2crn
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecadienoyl carnitine
type: Reaction

metaM imp e
initial amount: NaN
name: IMP(2-)
is: SBO:0000247
notes: FORMULA: C10H11N4O8P CHARGE: -2 INCHI: InChI=1S/C10H13N4O8P/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20)/p-2/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
has only substance units: false
boundary condition: false
is: CHEBI:58053
constant: false
initial concentration: 1.0
type: Species
is: HMDB00175

metaR ACETONEt2m
fast: false
notes: GENE_ASSOCIATION: (6566.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: NOTES:NCD
name: acetone mitochondrial transport via proton symport
reversible: true
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_ed4c04a2_c709_454d_bd90_3fa6845d0c00
is: A8K9Q8
initial concentration: NaN
is: SBO:0000252
constant: false
initial amount: NaN
is encoded by: hsa:192134
type: Species
name: B3GNT6
boundary condition: true
has only substance units: false

metaR C4CRNe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of butyryl carnitine into the extra cellular space
type: Reaction

metaM 5htrp e
initial concentration: 1.0
has only substance units: false
name: 5-hydroxy-L-tryptophan
type: Species
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
is: HMDB00472
constant: false
is: CHEBI:17780
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_ec8445bc_8770_4125_b1bc_a1217144e7f0
boundary condition: true
initial concentration: NaN
type: Species
is: Q9GZS9
initial amount: NaN
is: SBO:0000252
name: CHST5
is encoded by: hsa:23563
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_6c83f430_e260_4956_b2a6_ce7493a4642f
is encoded by: hsa:57665
constant: false
boundary condition: true
initial concentration: NaN
name: RDH14
is: SBO:0000252
initial amount: NaN
is: Q9HBH5
has only substance units: false
type: Species

metaR r2443
is: SBO:0000185
product: MODEL1310110001#
fast: false
reversible: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Proposed Fatty Acid Transporter (FAT) TCDB:4.C.1.1.5
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_f51f84fb_5eb7_401d_9160_296adf1c417f
is encoded by: hsa:AI934540
initial amount: NaN
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
name: _AI934540_1_c
initial concentration: NaN
constant: false

metaR PYDAMK
name: pyridoxamine kinase
kinetic law: MODEL1310110001#
fast: false
type: Reaction
product: MODEL1310110001#
reversible: false
is: SBO:0000176
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.35

metaR VITD3t2
product: MODEL1310110001#
reactant: MODEL1310110001#
reversible: false
is described by: ECO:0000000
fast: false
name: Vitamin D3 uptake
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:I am not sure how vitamin D3 is taken up from peripheral cells based on Vitamins, G.F.M. Ball,2004, Blackwell publishing, 1st ed (book) pg.193 IT

metaR NACHEX21ly
is described by: ECO:0000000
reversible: false
product: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
type: Reaction
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.52
notes: GENE_ASSOCIATION: (3074.1) or (3073.1) or (3073.1 and 3074.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
kinetic law: MODEL1310110001#
name: beta-N-acetylhexosaminidase, lysosomal

http://identifiers.org/biomodels.db/MODEL1310110001#_ab6378d4_e5eb_418e_9b34_f1c4f16abced
constant: false
is encoded by: hsa:3635
type: Species
boundary condition: true
is: SBO:0000252
has only substance units: false
is: Q92835
name: INPP5D
initial amount: NaN
initial concentration: NaN

metaM drib e
is: HMDB03224
is: CHEBI:28816
type: Species
has only substance units: false
initial amount: NaN
constant: false
is: SBO:0000247
notes: FORMULA: C5H10O4 CHARGE: 0 INCHI: InChI=1S/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m0/s1 EHMN_ABBREVIATION: C01801
boundary condition: false
name: 2-deoxy-D-ribose
initial concentration: 1.0

metaR NDPK3m
fast: false
modifier: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.6
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
reactant: MODEL1310110001#
is described by: ECO:0000254
product: MODEL1310110001#
is: SBO:0000176
reversible: true

metaR LEUKTRD4tr
kinetic law: MODEL1310110001#
type: Reaction
fast: false
is described by: ECO:0000000
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185
reversible: true
name: leukotriene intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ

http://identifiers.org/biomodels.db/MODEL1310110001#_f981a9f3_a239_4b6c_a7e9_ac2e1f95e3ed
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: O43181
type: Species
is encoded by: hsa:4724
is: SBO:0000252
name: NDUFS4
boundary condition: true
constant: false

metaR PGK
reversible: true
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (5230.1) or (375056.1) or (5232.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
type: Reaction
name: phosphoglycerate kinase
fast: false
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.2.3
product: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110001#_3dd7f3a5_fdbe_4b19_ba41_bb283bff5e94
constant: false
boundary condition: true
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:2348
type: Species
name: FOLR1

metaR EX 6dhf LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: haxglutamyl folate (DHF) exchange
type: Reaction

metaM dmnoncoa c
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C32H54N7O17P3S CHARGE: -4 INCHI: InChI=1/C32H56N7O17P3S/c1-19(2)7-6-8-20(3)9-10-23(41)60-14-13-34-22(40)11-12-35-30(44)27(43)32(4,5)16-53-59(50,51)56-58(48,49)52-15-21-26(55-57(45,46)47)25(42)31(54-21)39-18-38-24-28(33)36-17-37-29(24)39/h17-21,25-27,31,42-43H,6-16H2,1-5H3,(H,34,40)(H,35,44)(H,48,49)(H,50,51)(H2,33,36,37)(H2,45,46,47)/t20?,21-,25-,26-,27?,31-/m1/s1
boundary condition: false
is: HMDB11604
name: 4,8 dimethylnonanoyl-CoA
is: SBO:0000247
type: Species
initial concentration: 1.0

metaR RE1533M
reversible: true
reactant: MODEL1310110001#
is described by: ECO:0000000
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.2.1.17
product: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (10449.1) or (3032.1) or (3030.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:7923814,PMID:9568246,PMID:9920399 NOTES:
is version of: http://identifiers.org/ec-code/2.3.1.16
name: RE1533
type: Reaction
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_a66a0e12_89a6_434e_893e_331447242a07
initial amount: NaN
is encoded by: hsa:80025
initial concentration: NaN
boundary condition: true
constant: false
is: SBO:0000252
name: PANK2
type: Species
has only substance units: false

metaR r2516
fast: false
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.1.13.1
is described by: ECO:0000000
is: SBO:0000185
kinetic law: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:12739169,PMID:18305372 NOTES:

metaM dcsptn1crn m
is: HMDB06321
type: Species
boundary condition: false
has only substance units: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
name: docosa-4,7,10,13,16-pentaenoyl carnitine
initial concentration: 1.0
constant: false
is: SBO:0000247
initial amount: NaN

metaM atp x
is: SBO:0000247
initial amount: NaN
is: CHEBI:57299
has only substance units: false
initial concentration: 1.0
constant: false
type: Species
name: ATP(4-)
boundary condition: false
is: HMDB00538
is: C00002

metaR GLYSARPEPT1tc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of Glycylsarcosine by the apical PEPT1 amino acid transporters across the brush border cells of the enterocytes of the intestine, renal cells and brain.
type: Reaction

metaM gly m
is: C00037
initial concentration: 1.0
is: CHEBI:15428
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
is: HMDB00123
is: SBO:0000247
notes: FORMULA: C2H5NO2 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00045 EHMN_ABBREVIATION: C00037
constant: false
name: Glycine

metaR ETFQO
is version of: http://identifiers.org/ec-code/1.5.5.1
is: SBO:0000176
reversible: false
notes: GENE_ASSOCIATION: (2110.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.5.5.1 Confidence Level: 4 AUTHORS: PMID:10444348,PMID:12049629 NOTES:TV Ruzicka F, JBC, 1977
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
name: Electron transfer flavoprotein-ubiquinone oxidoreductase
is described by: ECO:0000000
type: Reaction

metaR ORNDC
name: Ornithine Decarboxylase
is described by: ECO:0000269
fast: false
is: SBO:0000176
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reversible: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.1.1.17
type: Reaction
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (4953.1) SUBSYSTEM: Urea cycle EC Number: 4.1.1.17 Confidence Level: 4 AUTHORS: PMID:2317811 NOTES:JLR- added proton to balance

metaR NDPK3n
reactant: MODEL1310110001#
name: nucleoside-diphosphate kinase (ATP:CDP),nuclear
fast: false
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
is: SBO:0000176
product: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#

metaM 3mb2coa m
name: 3-methylbut-2-enoyl-CoA(4-)
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:57344
constant: false
is: SBO:0000247
notes: FORMULA: C26H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C26H42N7O17P3S/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41)/p-4/t15-,19-,20-,21+,25-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01047 EHMN_ABBREVIATION: C03069
has only substance units: false
initial amount: NaN
is: HMDB01493

metaM imp c
is: C00130
is: HMDB00175
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H11N4O8P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00128 EHMN_ABBREVIATION: C00130
boundary condition: false
is: SBO:0000247
name: IMP
initial concentration: 1.0
is: CHEBI:58053
constant: false
type: Species

metaM alpro m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: CH6NS2X CHARGE: 1 EHMN_ABBREVIATION: C01242
type: Species
name: S-Aminomethyldihydrolipoylprotein
is: CHEBI:16882
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_f81b3c9e_561e_4773_9afc_b336cae21be6
is: SBO:0000252
has only substance units: false
is encoded by: hsa:1808
boundary condition: true
type: Species
initial amount: NaN
is: B4DR31
constant: false
name: DPYSL2
initial concentration: NaN

metaR RE2426C
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 0 AUTHORS: PMID:12044950 NOTES:
type: Reaction
is: SBO:0000176
fast: false
product: MODEL1310110001#
name: RE2426
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_ebf9071f_5756_4704_b8a9_f4f242da2d70
type: Species
boundary condition: true
name: NPR2
is: SBO:0000252
is encoded by: hsa:4882
has only substance units: false
is: P20594
initial amount: NaN
constant: false
initial concentration: NaN

metaR r1551
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110001#
fast: false
type: Reaction

metaM na1 r
notes: FORMULA: Na CHARGE: 1 INCHI: InChI=1S/Na/q+1 HEPATONET_1.0_ABBREVIATION: HC00763 EHMN_ABBREVIATION: C01330
initial concentration: 1.0
name: sodium(1+)
is: HMDB00588
constant: false
boundary condition: false
initial amount: NaN
is: CHEBI:29101
type: Species
has only substance units: false
is: SBO:0000247

metaM 5htrp c
is: CHEBI:17780
type: Species
notes: FORMULA: C11H12N2O3 CHARGE: 0 INCHI: InChI=1S/C11H12N2O3/c12-9(11(15)16)3-6-5-13-10-2-1-7(14)4-8(6)10/h1-2,4-5,9,13-14H,3,12H2,(H,15,16)/t9-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00472 EHMN_ABBREVIATION: C00643
initial amount: NaN
is: SBO:0000247
is: HMDB00472
constant: false
boundary condition: false
has only substance units: false
name: 5-hydroxy-L-tryptophan
initial concentration: 1.0

metaR PECDCHe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of pectins with deoxycholic acid in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_cc5cbc51_582b_44ad_9003_3e8517e1cc63
initial concentration: NaN
is: P19801
is: SBO:0000252
initial amount: NaN
boundary condition: true
type: Species
constant: false
has only substance units: false
is encoded by: hsa:26
name: ABP1

metaM icit x
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)/p-3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
initial concentration: 1.0
initial amount: NaN
type: Species
is: CHEBI:16087
boundary condition: false
is: HMDB00193
is: SBO:0000247
name: isocitrate(3-)
has only substance units: false
constant: false

metaR EX gmp LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GMP exchange
type: Reaction

metaR MMSAD1m
name: methylmalonate-semialdehyde dehydrogenase
reversible: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (4329.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 1.2.1.27 Confidence Level: 4 AUTHORS: PMID:10947204,PMID:1527093 NOTES:TV Also converts propanal to propanoyl-CoA
kinetic law: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.2.1.27
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction

metaR r0283
modifier: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (AA676725.1) or (196951.1) or (2584.1) or (2585.1) SUBSYSTEM: beta-Alanine metabolism EC Number: 6.3.2.11 Confidence Level: 0 AUTHORS: PMID:448355,PMID:487087 NOTES:
is version of: http://identifiers.org/ec-code/2.7.1.157
reactant: MODEL1310110001#
fast: false
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.1.6
type: Reaction
reversible: false
is described by: ECO:0000000
name: L-Histidine:beta-alanine ligase (AMP-forming) Alanine and aspartate metabolism / Histidine metabolism / beta-Alanine metabolism EC:6.3.2.11

metaM n2m2masn g
constant: false
notes: FORMULA: C50H83N4O35X CHARGE: 0
has only substance units: false
initial concentration: 1.0
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)
is: C11530
type: Species
initial amount: NaN
boundary condition: false
is: SBO:0000247

metaR G6PDH1rer
reversible: true
is described by: ECO:0000269
modifier: MODEL1310110001#
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
is version of: http://identifiers.org/ec-code/1.1.1.47
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: (9563.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.47 Confidence Level: 4 AUTHORS: PMID:10349511,PMID:12831846,PMID:2156506 NOTES:tv, jp NCD
product: MODEL1310110001#

metaM oaa m
is: CHEBI:16452
is: HMDB00223
initial amount: NaN
initial concentration: 1.0
constant: false
has only substance units: false
boundary condition: false
type: Species
is: C00036
notes: FORMULA: C4H2O5 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00044 EHMN_ABBREVIATION: C00036
is: SBO:0000247
name: Oxaloacetate

metaM pristcoa c
boundary condition: false
type: Species
is: CHEBI:51341
name: pristanoyl coa
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/t26?,27?,28?,29-,32-,33-,34+,38-/m1/s1/f/h42-43,53-54,56,58H,41H2
has only substance units: false
initial amount: NaN

metaR RBFK
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.1.26
type: Reaction
fast: false
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (55312.1) SUBSYSTEM: Vitamin B2 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
name: riboflavin kinase
is described by: ECO:0000269
reversible: false

metaM ksi pre34 g
is: SBO:0000247
initial concentration: 1.0
is: C00130
boundary condition: false
notes: FORMULA: C241H385N17O202S10X CHARGE: -11
is: CHEBI:58053
constant: false
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 34
is: HMDB00175
has only substance units: false
type: Species

metaM dcsptn1crn c
name: docosa-4,7,10,13,16-pentaenoyl carnitine
constant: false
initial amount: NaN
is: HMDB06321
has only substance units: false
notes: FORMULA: C29H47NO4 CHARGE: 0 INCHI: InChI=1/C29H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-29(33)34-27(25-28(31)32)26-30(2,3)4/h9-10,12-13,15-16,18-19,21-22,27H,5-8,11,14,17,20,23-26H2,1-4H3/b10-9+,13-12+,16-15+,19-18+,22-21+
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0

metaM ksi deg13 l
boundary condition: false
is: SBO:0000247
has only substance units: false
type: Species
name: keratan sulfate I, degradation product 13
constant: false
notes: FORMULA: C174H280N12O150S8 CHARGE: -8
initial concentration: 1.0
is: HMDB01354
initial amount: NaN
is: CHEBI:57455

metaR PNTOte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reactant: MODEL1310110001#
is described by: ECO:0000134
type: Reaction
fast: false
reversible: true
kinetic law: MODEL1310110001#
name: Transport of (R)-Pantothenate
is: SBO:0000185
product: MODEL1310110001#

metaR FACOAL245 2
kinetic law: MODEL1310110001#
is described by: ECO:0000269
is: SBO:0000176
modifier: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
reactant: MODEL1310110001#
reversible: true
name: fatty-acid--CoA ligase
type: Reaction
is version of: http://identifiers.org/ec-code/6.2.1.3
product: MODEL1310110001#

metaR EX lac L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Lactate exchange
type: Reaction

metaM 5oxpro e
type: Species
initial amount: NaN
has only substance units: false
is: CHEBI:57606
is: HMDB00267
constant: false
name: 5-oxoprolinate
boundary condition: false
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1
initial concentration: 1.0
is: SBO:0000247

metaR GPIDAer
type: Reaction
name: glycophosphatidylinositol (GPI) deacylase, endoplasmic reticulum
is described by: ECO:0000000
product: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (80055.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14734546 NOTES:NCD
reversible: false
modifier: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_1e3aaac3_eb10_4b8f_8694_16794a51b474
constant: false
is encoded by: hsa:23563
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
name: CHST5
initial concentration: NaN
is: SBO:0000252

metaM 1pyr5c m
is: CHEBI:15893
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
boundary condition: false
constant: false
is: SBO:0000247
name: 1-Pyrroline-5-carboxylate
is: C03912
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false
is: HMDB01301

http://identifiers.org/biomodels.db/MODEL1310110001#_ca27a1c6_f8c7_40b1_bcbe_de77aa120828
type: Species
initial concentration: NaN
initial amount: NaN
is: O60762
is encoded by: hsa:8813
is: SBO:0000252
has only substance units: false
name: DPM1
boundary condition: true
constant: false

metaR RBK
name: ribokinase
notes: GENE_ASSOCIATION: (64080.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 2 AUTHORS: NOTES:
reversible: false
type: Reaction
reactant: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.1.15
is: SBO:0000176
is described by: ECO:0000304

metaM nh4 m
is: C01342
name: Ammonium
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB00051
has only substance units: false
boundary condition: false
initial concentration: 1.0
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: CHEBI:28938
type: Species

metaR EX btn LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Biotin exchange
type: Reaction

metaR NACHEX14ly
name: beta-N-acetylhexosaminidase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.52
modifier: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
reversible: false
product: MODEL1310110001#
fast: false

metaR EX tethex3 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: tetracosahexaenoic acid, n-3 exchange
type: Reaction

metaM hmgcoa c
has only substance units: false
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
name: Hydroxymethylglutaryl-CoA
initial amount: NaN
type: Species
constant: false
is: HMDB01375

metaM 3octdece1coa c
is: HMDB13336
name: 3-hydroxyoctadecenoylcoa
is: SBO:0000247
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C39H64N7O18P3S CHARGE: -4
type: Species
initial concentration: 1.0
initial amount: NaN

metaM gdp c
is: HMDB01201
boundary condition: false
is: SBO:0000247
name: GDP
constant: false
is: C00035
type: Species
is: CHEBI:58189
initial concentration: 1.0
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035

http://identifiers.org/biomodels.db/MODEL1310110001#_aae52a41_80c5_4f9e_890a_ffa2a34f057f
boundary condition: true
initial amount: NaN
constant: false
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: SLC22A1
is encoded by: hsa:6580
type: Species
is: O15245

metaM nh4 n
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
boundary condition: false
initial amount: NaN
name: ammonium
initial concentration: 1.0
constant: false
is: HMDB00051
is: CHEBI:28938
has only substance units: false
type: Species

metaR EX nh4 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Ammonia exchange
type: Reaction

metaM lac L x
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:16651
name: (S)-lactate
is: HMDB00190
notes: FORMULA: C3H5O3 CHARGE: -1 INCHI: InChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/p-1/t2-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00177
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_9f9d3160_71ee_4f3f_90e9_cb0203edc7e8
initial concentration: NaN
type: Species
is encoded by: hsa:9551
boundary condition: true
is encoded by: hsa:517
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G2:ATP5I:ATP5J:ATP5J2
initial amount: NaN
has part: F8W7V3
constant: false
is: SBO:0000297
has only substance units: false

metaM leuktrC4 r
initial amount: NaN
boundary condition: false
is: CHEBI:57973
initial concentration: 1.0
notes: FORMULA: C30H45N3O9S CHARGE: -2 INCHI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/p-2/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00898 EHMN_ABBREVIATION: C02166
type: Species
constant: false
has only substance units: false
is: HMDB01198
is: SBO:0000247
name: leukotriene C4(2-)

http://identifiers.org/biomodels.db/MODEL1310110001#_77836753_c287_42fa_aa86_a1272894c9e6
boundary condition: true
initial amount: NaN
is encoded by: hsa:5160
initial concentration: NaN
name: PDHA1
constant: false
is: P08559
type: Species
is: SBO:0000252
has only substance units: false

metaR r0345
is described by: ECO:0000000
name: ATP:AMP phosphotransferase Purine metabolism EC:2.7.4.11
modifier: MODEL1310110001#
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.99.3
is version of: http://identifiers.org/ec-code/1.3.99.13
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: (27034.1) or (28976.1) or (33.1) or (34.1) or (37.1) or (51.1) or (8310.1) or (AI285872.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.11 Confidence Level: 0 AUTHORS: PMID:11768308 NOTES:
kinetic law: MODEL1310110001#

metaM gtp e
boundary condition: false
has only substance units: false
constant: false
type: Species
is: SBO:0000247
name: GTP(4-)
is: HMDB01273
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
initial amount: NaN
initial concentration: 1.0

metaM na1 e
is: C01330
type: Species
has only substance units: false
notes: FORMULA: Na CHARGE: 1
is: CHEBI:4541
boundary condition: false
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247
is: HMDB00588
constant: false
name: Sodium

metaM 2ddecdicoa x
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
name: 2,6-dodecadienoylcoa
boundary condition: false
initial amount: NaN
is: HMDB11123
type: Species
is: SBO:0000247
has only substance units: false
constant: false
is: C05279
initial concentration: 1.0

metaM 5oxpro c
is: SBO:0000247
type: Species
notes: FORMULA: C5H6NO3 CHARGE: -1 INCHI: InChI=1S/C5H7NO3/c7-4-2-1-3(6-4)5(8)9/h3H,1-2H2,(H,6,7)(H,8,9)/p-1 HEPATONET_1.0_ABBREVIATION: HC00856 EHMN_ABBREVIATION: C01879
is: CHEBI:57606
initial amount: NaN
is: HMDB00267
constant: false
name: 5-oxoprolinate
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR FAOXC5C5DCc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of glutaryl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_418e514c_0167_4dbc_b902_a474b1a04819
is: SBO:0000252
initial concentration: NaN
type: Species
is: Q9Y2Z9
is encoded by: hsa:51004
initial amount: NaN
name: COQ6
has only substance units: false
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_ab01de63_223a_4ea1_bb3d_4f1ec82e3870
boundary condition: true
initial amount: NaN
has only substance units: false
initial concentration: NaN
is encoded by: hsa:171425
constant: false
name: CLYBL
type: Species
is: SBO:0000252
is: Q8N0X4

metaR ALDD2y
modifier: MODEL1310110001#
reactant: MODEL1310110001#
name: aldehyde dehydrogenase (acetaldehyde, NADP)
fast: false
type: Reaction
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.2.1.5
is version of: http://identifiers.org/ec-code/1.2.1.3
notes: GENE_ASSOCIATION: (223.1) or (221.1) or (218.1) or (8854.1) or (8854.3) or (222.1) or (8854.2) or (224.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.4 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:See also ALDH1 (1.2.1.3); r0177
is version of: http://identifiers.org/ec-code/1.2.1.36
is: SBO:0000176
product: MODEL1310110001#
reversible: false
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_9eb9c590_73d9_40c1_a4bb_8aec5233c23e
initial amount: NaN
is: SBO:0000252
constant: false
is: Q96Q11
is encoded by: hsa:51095
name: TRNT1
boundary condition: true
has only substance units: false
initial concentration: NaN
type: Species

metaR APOC LYS BTNP
kinetic law: MODEL1310110001#
fast: false
type: Reaction
name: proteolysis of apoC-Lys-btn
reactant: MODEL1310110001#
is: SBO:0000176
reversible: false
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is described by: ECO:0000000

metaR FACOAL245 1
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:NJ
is described by: ECO:0000000
fast: false
type: Reaction
name: fatty-acid--CoA ligase
is: SBO:0000176
reactant: MODEL1310110001#

metaM Lcystin e
constant: false
has only substance units: false
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
is: HMDB00192
type: Species
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: L-cystine
is: CHEBI:16283
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_8bc1ad20_96a8_4db9_9bab_41801b92741c
is: SBO:0000252
has only substance units: false
type: Species
is encoded by: hsa:8854
constant: false
initial concentration: NaN
initial amount: NaN
boundary condition: true
is: F5H2Y9
name: ALDH1A2

metaM bhb c
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: SBO:0000247
name: (R)-3-hydroxybutyrate
is: CHEBI:10983
constant: false
is: HMDB00011
boundary condition: false
type: Species
has only substance units: false
initial amount: NaN
initial concentration: 1.0

metaR r1090
reversible: false
type: Reaction
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: TCDB:2.A.47.1.9 TCDB:2.A.29.7.2
kinetic law: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#
is described by: ECO:0000000
fast: false

metaR r0287
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (6576.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.16 Confidence Level: 0 AUTHORS: PMID:10806397,PMID:1121274,PMID:1679347,PMID:1735445,PMID:1979337,PMID:2048733,PMID:3194209,PMID:6378901,PMID:8241273 NOTES:
reactant: MODEL1310110001#
product: MODEL1310110001#
name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:2.3.1.16
type: Reaction
reversible: false
modifier: MODEL1310110001#
fast: false
is described by: ECO:0000000
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_bb1b18e2_644b_4fa4_97ae_d022f743cfbc
is: SBO:0000252
is encoded by: hsa:4726
initial amount: NaN
constant: false
type: Species
initial concentration: NaN
boundary condition: true
has only substance units: false
is: Q6IBC4
name: NDUFS6

metaR G14T2g
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.90
is: SBO:0000176
product: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/2.4.1.38
fast: false
reversible: false
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
is version of: http://identifiers.org/ec-code/2.4.1.22
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
is described by: ECO:0000000
kinetic law: MODEL1310110001#

metaM gly c
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0
boundary condition: false
is: CHEBI:3339
has only substance units: false
is: C00037
name: Glycine
constant: false
initial amount: NaN
type: Species
is: SBO:0000247
is: HMDB00123

metaR FUMAC
notes: GENE_ASSOCIATION: (2184.1) SUBSYSTEM: Tyrosine metabolism EC Number: 3.7.1.2 Confidence Level: 4 AUTHORS: NOTES:NCD
modifier: MODEL1310110001#
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
fast: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.7.1.2
product: MODEL1310110001#
kinetic law: MODEL1310110001#
name: fumarylacetoacetase
reversible: false

metaM gtp c
has only substance units: false
is: SBO:0000247
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: HMDB01273
constant: false
is: CHEBI:37565
initial concentration: 1.0
type: Species
initial amount: NaN
is: C00044
boundary condition: false
name: GTP

metaM 3dodtricoa m
is: SBO:0000247
name: 3,6,9-dodecatrienoylcoa
initial concentration: 1.0
is: HMDB11123
is: C05279
initial amount: NaN
notes: FORMULA: C33H48N7O17P3S CHARGE: -4
constant: false
boundary condition: false
type: Species
has only substance units: false

metaM gdp g
name: GDP(3-)
is: CHEBI:58189
initial concentration: 1.0
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
initial amount: NaN
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
is: HMDB01201

metaR EX ocdcea LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: octadecenoate (n-C18:1) exchange
type: Reaction

metaM CE5160 r
is: CHEBI:57923
notes: FORMULA: C39H62N7O18P3S CHARGE: -4 INCHI: InChI=1/C39H66N7O18P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-27(47)22-30(49)68-21-20-41-29(48)18-19-42-37(52)34(51)39(2,3)24-61-67(58,59)64-66(56,57)60-23-28-33(63-65(53,54)55)32(50)38(62-28)46-26-45-31-35(40)43-25-44-36(31)46/h11-12,25-26,28,32-34,38,50-51H,4-10,13-24H2,1-3H3,(H,41,48)(H,42,52)(H,56,57)(H,58,59)(H2,40,43,44)(H2,53,54,55)/p-4/b12-11-/t28-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5160
name: 3-oxo-cis-9-octadecenoyl-CoA
is: SBO:0000247
initial amount: NaN
constant: false
initial concentration: 1.0
type: Species
has only substance units: false
boundary condition: false

metaR GCC2cm
reactant: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.10 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
is version of: http://identifiers.org/ec-code/1.8.1.4
product: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.4.4.2
is described by: ECO:0000269
name: glycine-cleavage complex (lipoamide), mitochondrial
is version of: http://identifiers.org/ec-code/2.1.2.10
fast: false
is: SBO:0000176
type: Reaction

metaR RE3347C
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110001#
fast: false
is described by: ECO:0000000
name: RE3347
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin B2 metabolism EC Number: 1.5.1.29 Confidence Level: 0 AUTHORS: PMID:10620517 NOTES:
reactant: MODEL1310110001#
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_b6ec95ae_fe22_4a1e_91b6_0b39b2549c9a
initial concentration: NaN
type: Species
has only substance units: false
name: ST8SIA5
is: SBO:0000252
initial amount: NaN
boundary condition: true
is encoded by: hsa:29906
constant: false
is: O15466

http://identifiers.org/biomodels.db/MODEL1310110001#_7f5a852e_7de4_4b05_9218_61813d799a36
initial amount: NaN
is: P23109
has only substance units: false
is encoded by: hsa:270
constant: false
is: SBO:0000252
name: AMPD1
type: Species
initial concentration: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_de159d1a_c9ef_49c1_8b7e_b6150497ac9c
initial concentration: NaN
has only substance units: false
initial amount: NaN
is encoded by: hsa:522
boundary condition: true
is: SBO:0000297
type: Species
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
constant: false
has part: Q6IB54

http://identifiers.org/biomodels.db/MODEL1310110001#_3c423f92_ffc6_4873_bec5_57d842d65bff
has only substance units: false
boundary condition: true
constant: false
initial amount: NaN
is encoded by: hsa:AI653169
name: _AI653169_1_c
is: SBO:0000252
type: Species
initial concentration: NaN

metaM Lcystin c
is: CHEBI:16283
notes: FORMULA: C6H12N2O4S2 CHARGE: 0 INCHI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1
boundary condition: false
constant: false
is: HMDB00192
initial concentration: 1.0
type: Species
initial amount: NaN
is: SBO:0000247
name: L-cystine
has only substance units: false

metaR PI4PLC
fast: false
is: SBO:0000176
reactant: MODEL1310110001#
product: MODEL1310110001#
name: phosphatidylinositol 4-phosphate phospholipase C
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.4.11
notes: GENE_ASSOCIATION: (23236.1) or (51196.1) or (9651.1) or (113026.1) or (89869.1) or (23007.1) or (5334.1) or (5331.1) or (5333.1) or (257068.1) or (5332.1) or (23236.2) or (5335.1) or (5335.2) or (5336.1) or (5330.1) or (5332.2) or (84812.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10702670,PMID:10702683,PMID:10760467,PMID:11022047,PMID:11022048,PMID:11118617,PMID:12117804,PMID:12213492,PMID:12416999,PMID:13333955,PMID:15140260,PMID:1644792,PMID:2167438,PMID:7607669,PMID:7612006,PMID:7633416,PMID:7789993,PMID:7835906,PMID:7849701,PMID:7890667,PMID:8530101,PMID:9345909 NOTES:NCD
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110001#_6ec4c275_9fdd_4df2_8f9d_4236c7603595
is: F5GWS5
is encoded by: hsa:55811
has only substance units: false
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
name: ADCY10
is: SBO:0000252
type: Species

metaR GGT5r
type: Reaction
name: Gamma-glutamyltransferase 5
fast: false
reversible: true
is described by: ECO:0000134
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (2687.1) SUBSYSTEM: Eicosanoid metabolism EC Number: 2.3.2.2 Confidence Level: 4 AUTHORS: PMID:18357468,PMID:18357469,PMID:6120203 NOTES:Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). NJ
modifier: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.2.2
is: SBO:0000176

metaR r0494
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.5 Confidence Level: 0 AUTHORS: PMID:15652174,PMID:16752921,PMID:17095758 NOTES:
product: MODEL1310110001#
is described by: ECO:0000000
reversible: true
name: dTDP diphosphohydrolase Pyrimidine metabolism EC:3.6.1.5
is: SBO:0000176
type: Reaction
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
fast: false

metaM bhb e
initial concentration: 1.0
is: SBO:0000247
constant: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
is: CHEBI:10983
is: HMDB00011
name: (R)-3-hydroxybutyrate
type: Species
boundary condition: false
initial amount: NaN
has only substance units: false

metaR FAOXC121x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C12:1)x
type: Reaction

metaR LNLNCGt
kinetic law: MODEL1310110001#
name: fatty acid transport via diffusion
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction
is described by: ECO:0000000
reversible: true

metaR EX h LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for proton
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_cf61d4f6_70a5_44f6_b559_2fcc2b17e5a4
type: Species
is encoded by: hsa:3613
initial amount: NaN
is: O14732
name: IMPA2
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN

metaM gly e
is: CHEBI:3339
initial concentration: 1.0
notes: FORMULA: C2H5NO2 CHARGE: 0
is: C00037
boundary condition: false
constant: false
initial amount: NaN
name: Glycine
has only substance units: false
type: Species
is: SBO:0000247
is: HMDB00123

metaR FAOXC246226x
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:peroxisomal (very long chain FA) - - in peroxisome, no fad, 1ste set of beta-ox is by acyl-coa oxidase (passes electrons directly to o2 -> h2o2) c24:6 -> c22:6 4 step FAO lumped also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
type: Reaction
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.35
name: Beta oxidation of long chain fatty acid
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16
modifier: MODEL1310110001#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#

metaM 2octdectecoa m
name: 2,6,9,12-octadecatetraenoylcoa
initial amount: NaN
notes: FORMULA: C39H58N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/5280355
is: SBO:0000247
boundary condition: false
type: Species
constant: false

metaM HC00319 m
notes: FORMULA: C3H2O4 CHARGE: -2 INCHI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)
initial concentration: 1.0
type: Species
has only substance units: false
is: SBO:0000247
constant: false
name: Malonate
boundary condition: false
initial amount: NaN
is: CHEBI:30794

metaR ORNTArm
reactant: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000269
name: ornithine transaminase reversible (m)
is version of: http://identifiers.org/ec-code/2.6.1.13
reversible: true
notes: GENE_ASSOCIATION: (4942.1) SUBSYSTEM: Urea cycle EC Number: 2.6.1.13 Confidence Level: 4 AUTHORS: PMID:9514741 NOTES:kh 1/7/03 SAB m
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_246ba289_ded5_4d4b_85c7_9cd64e94ce69
initial concentration: NaN
is encoded by: hsa:93010
is: SBO:0000252
initial amount: NaN
has only substance units: false
name: B3GNT7
constant: false
type: Species
boundary condition: true
is: Q8NFL0

http://identifiers.org/biomodels.db/MODEL1310110001#_b5500b30_3d0e_46c1_bbfb_5022226c83c6
boundary condition: true
is: SBO:0000252
is encoded by: hsa:7378
constant: false
name: UPP1
initial amount: NaN
has only substance units: false
type: Species
initial concentration: NaN

metaR r1559
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
product: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
fast: false

metaR EX 3tdcrn
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy-tetradecanoyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_f5dc5ec1_9163_4e4b_999e_8b1bcc280515
type: Species
initial concentration: NaN
name: TALDO1
constant: false
is: SBO:0000252
is: P37837
is encoded by: hsa:6888
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_1827699c_5264_46c9_96f3_2736cc5d8bfa
type: Species
has only substance units: false
is encoded by: hsa:53905
constant: false
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
name: DUOX1
boundary condition: true

metaR ACCOAC
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: false
name: acetyl-CoA carboxylase
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_cb2141ca_a7ff_4953_ae7d_3cb7076f2ad5
type: Species
is: P07205
is: SBO:0000252
name: PGK2
boundary condition: true
is encoded by: hsa:5232
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN

metaR EX dag hs LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for diglyceride
type: Reaction

metaR r0340
is described by: ECO:0000000
is: SBO:0000176
modifier: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Unassigned EC Number: 2.7.1.31 Confidence Level: 0 AUTHORS: PMID:16753811,PMID:216417,PMID:2537226,PMID:6252205 NOTES:
name: ATP:(R)-glycerate 3-phosphotransferase Glycine, serine and threonine metabolism EC:2.7.1.31
product: MODEL1310110001#
fast: false
reversible: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.1.38
kinetic law: MODEL1310110001#

metaR ADNK1m
is: SBO:0000176
reactant: MODEL1310110001#
reversible: false
fast: false
is described by: ECO:0000000
type: Reaction
product: MODEL1310110001#
name: adenosine kinase, mitochondrial
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.20 Confidence Level: 1 AUTHORS: NOTES:IT

metaR C12DCACOT
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: thioesterification of dodecanedioyl coa for release into cytosol
type: Reaction

metaM hexdiac c
initial amount: NaN
is: C08260
type: Species
initial concentration: 1.0
is: HMDB00672
boundary condition: false
notes: FORMULA: C16H28O4 CHARGE: -2
name: hexadecanediocacid
constant: false
has only substance units: false
is: SBO:0000247

metaR H3ETer
fast: false
reactant: MODEL1310110001#
name: H3 phosphoethanolaminyl transferase, endoplasmic reticulum
kinetic law: MODEL1310110001#
reversible: false
is: SBO:0000176
type: Reaction
product: MODEL1310110001#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (23556.1) or (23556.2) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10574991 NOTES:NCD
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_716df807_b26a_4ce8_be88_37c641aec004
is encoded by: hsa:29926
has only substance units: false
boundary condition: true
type: Species
is: Q96IJ6
constant: false
is: SBO:0000252
name: GMPPA
initial concentration: NaN
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_3216a1dc_43a0_4f6c_a78e_ad54b6e3dbb2
initial amount: NaN
type: Species
name: SLC25A12
boundary condition: true
has only substance units: false
is encoded by: hsa:8604
is: O75746
initial concentration: NaN
constant: false
is: SBO:0000252

metaR EX dpcoa LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for dpcoa
type: Reaction

metaM gdp e
has only substance units: false
constant: false
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:58189
initial amount: NaN
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
name: GDP(3-)
is: HMDB01201
initial concentration: 1.0

metaM 5tedtricoa x
is: HMDB02288
is: SBO:0000247
has only substance units: false
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
name: 5,8,11-tetradecatrienoylcoa
boundary condition: false

metaR H2O2tp
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: PMID:2989289 NOTES:NCD
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000000
reversible: true
name: hydrogen peroxide peroxisomal transport via diffusion
type: Reaction
is: SBO:0000185
fast: false

metaR SPHINGStl
name: sphingosine intracellular transport
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, however sphingosine manages to get in different compartments of cells. NOT presumed to be flip-flop. NJ
reactant: MODEL1310110001#
product: MODEL1310110001#

metaR EX amp LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: AMP exchange
type: Reaction

metaR APOC LYS BTNPm
kinetic law: MODEL1310110001#
type: Reaction
name: proteolysis of apoC-Lys-btn, mitochondrial
reversible: false
fast: false
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Biotin metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_9fe4a828_bdbd_4f74_a6a3_77d165ad3a87
is encoded by: hsa:6718
constant: false
is: P51857
boundary condition: true
initial concentration: NaN
type: Species
initial amount: NaN
has only substance units: false
name: AKR1D1
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_9463754f_7e7e_4daf_8168_67a290047edc
is: P49247
is: SBO:0000252
is encoded by: hsa:22934
boundary condition: true
initial amount: NaN
name: RPIA
type: Species
constant: false
has only substance units: false
initial concentration: NaN

metaM retn e
is: CHEBI:35291
is: SBO:0000247
name: all-trans-retinoate
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
constant: false
is: HMDB01852
initial amount: NaN
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0

metaR OCTDECCPT2
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

metaR EX dchac LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for deoxycholic acid
type: Reaction

metaM tdcrn e
is: SBO:0000247
name: myristoyl carnitine
is: HMDB05066
notes: FORMULA: C21H41NO4 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
boundary condition: false

metaM cholate c
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
is: HMDB00619
boundary condition: false
is: CHEBI:29747
initial concentration: 1.0
name: Cholate
is: SBO:0000247
has only substance units: false
constant: false
type: Species
initial amount: NaN

metaM co e
has only substance units: false
is: CHEBI:17245
type: Species
initial concentration: 1.0
is: HMDB01361
is: SBO:0000247
boundary condition: false
constant: false
name: carbon monoxide
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
initial amount: NaN

metaM HC02202 e
initial concentration: 1.0
type: Species
boundary condition: false
name: prostaglandin A1(1-)
initial amount: NaN
is: CHEBI:57398
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
is: SBO:0000247
has only substance units: false
constant: false

metaR r0178
is described by: ECO:0000000
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (2222.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.24 Confidence Level: 0 AUTHORS: PMID:3190233,PMID:656447,PMID:7616245,PMID:7814412 NOTES:
is version of: http://identifiers.org/ec-code/2.5.1.21
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
name: Succinate-semialdehyde:NAD+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.24 EC:1.2.1.16
modifier: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
reversible: true

metaR r1669
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
product: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
name: Y+LAT2 Utilized transport

metaM dolmanp U c
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: CHEBI:15809
name: Dolichyl phosphate D-mannose, human uterine homolog
constant: false
notes: FORMULA: C1085H1780O90P10 CHARGE: -10 INCHI: InChI=1S/C31H55O9P/c1-22(2)11-7-12-23(3)13-8-14-24(4)15-9-16-25(5)17-10-18-26(6)19-20-38-41(36,37)40-31-30(35)29(34)28(33)27(21-32)39-31/h11,13,15,17,26-35H,7-10,12,14,16,18-21H2,1-6H3,(H,36,37)/b23-13+,24-15+,25-17-/t26?,27-,28-,29+,30+,31?/m1/s1

metaR OCTDECCPT1
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: transport of Octadecenoyl-CoA into mitochondrial matrix
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_9f353938_601b_410e_9a7f_48da1d6591f9
boundary condition: true
is encoded by: hsa:80025
is: SBO:0000252
initial amount: NaN
name: PANK2
type: Species
has only substance units: false
initial concentration: NaN
constant: false
is: Q6P1K9

metaR GALASE9ly
modifier: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.18
name: beta-galactosidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.23
kinetic law: MODEL1310110001#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) or (5476.1) and (2720.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.23 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.4.16.5
reactant: MODEL1310110001#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4

metaR EX tyr L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tyrosine exchange
type: Reaction

metaR r0179
is: SBO:0000176
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: Succinate-semialdehyde:NADP+ oxidoreductase Glutamate metabolism / Tyrosine metabolism / Butanoate metabolism EC:1.2.1.16
type: Reaction
modifier: MODEL1310110001#
reversible: true
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (AI656480.1) or (BE042354.1) or (3939.1) or (92483.1) or (3945.1) or (3948.1) SUBSYSTEM: Glutamate metabolism EC Number: 1.2.1.16 Confidence Level: 0 AUTHORS: PMID:4066712,PMID:7814412 NOTES:
is version of: http://identifiers.org/ec-code/1.1.1.27
is described by: ECO:0000000

metaR CYTK13n
modifier: MODEL1310110001#
name: cytidylate kinase (dCMP,dATP),nuclear
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
fast: false
is: SBO:0000176
product: MODEL1310110001#
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000269
reversible: true
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.14

metaM nh4 e
type: Species
is: HMDB00051
notes: FORMULA: H4N CHARGE: 1 INCHI: InChI=1S/H3N/h1H3/p+1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
boundary condition: false
is: CHEBI:28938
constant: false
name: ammonium
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR PI45P3K
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.11.1
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.153
is described by: ECO:0000000
modifier: MODEL1310110001#
fast: false
product: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5293.1 and 8503.1) or (5296.1 and 5290.1) or (5293.1 and 5295.1) or (5293.1 and 5295.3) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (5295.2 and 5290.1) or (10870.1 and 5294.1) or (23533.1 and 5294.1) or (5295.2 and 5293.1) or (5290.1 and 5295.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (5291.1 and 8503.1) or (5293.1 and 5296.1) or (5295.2 and 5291.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.153 Confidence Level: 4 AUTHORS: PMID:12507995,PMID:15780590,PMID:2174051,PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989 NOTES:NCD
is: SBO:0000176
name: phosphatidylinositol 4,5-bisphosphate 3-kinase
type: Reaction

metaR LEUKTRA4tr
reversible: true
is: SBO:0000185
kinetic law: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#
name: leukotriene intracellular transport
type: Reaction
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism, presumed diffusion NJ

http://identifiers.org/biomodels.db/MODEL1310110001#_57a39c9c_bd50_46c4_912d_918cb3e43b5d
type: Species
is: SBO:0000252
has only substance units: false
initial concentration: NaN
boundary condition: true
constant: false
name: SMS
is: P52788
is encoded by: hsa:6611
initial amount: NaN

metaR FAOXC14C12m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14-->C12)m
type: Reaction

metaR r1668
name: Y+LAT2 Utilized transport
product: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110001#
fast: false
reversible: true
modifier: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#

metaR r1998
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
modifier: MODEL1310110001#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
product: MODEL1310110001#
reactant: MODEL1310110001#
reversible: false

metaM dhlam m
initial concentration: 1.0
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C8H17NOS2 CHARGE: 0 INCHI: InChI=1S/C8H17NOS2/c9-8(10)4-2-1-3-7(12)5-6-11/h7,11-12H,1-6H2,(H2,9,10) HEPATONET_1.0_ABBREVIATION: HC00437 EHMN_ABBREVIATION: C00579
is: HMDB00985
name: dihydrolipoamide
has only substance units: false
boundary condition: false
is: CHEBI:17694
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_76a6d1a0_2a9b_489b_91b5_3d3daf010635
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: ADH1A:ADH1C
is: SBO:0000297
has part: P00326
type: Species
boundary condition: true
is encoded by: hsa:126
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_055a4918_f37e_414f_9e9d_9cb1e4408609
initial amount: NaN
is encoded by: hsa:2597
type: Species
has only substance units: false
initial concentration: NaN
name: GAPDH
constant: false
is: E7EUT4
boundary condition: true
is: SBO:0000252

metaM retn c
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/p-1/b9-6+,12-11+,15-8+,16-14+ HEPATONET_1.0_ABBREVIATION: HC00532 EHMN_ABBREVIATION: C00777
type: Species
boundary condition: false
is: CHEBI:35291
is: HMDB01852
initial amount: NaN
name: all-trans-retinoate
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_f5907bd8_f588_4c01_8c53_f83a07e9b193
has only substance units: false
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:56606
is: Q9NRM0
name: SLC2A9
constant: false
initial concentration: NaN

metaM tdcrn c
constant: false
is: HMDB05066
is: SBO:0000247
notes: FORMULA: C21H41NO4 CHARGE: 0
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
boundary condition: false
name: myristoyl carnitine

metaM cholate e
is: HMDB00619
notes: FORMULA: C24H39O5 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00502 EHMN_ABBREVIATION: C00695
boundary condition: false
is: CHEBI:29747
is: SBO:0000247
initial concentration: 1.0
constant: false
name: Cholate
initial amount: NaN
type: Species
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_86fa463e_ba26_429f_9aa2_c9e82143fbfc
type: Species
constant: false
name: RRM1:RRM2
has part: P31350
boundary condition: true
initial concentration: NaN
has part: P23921
is encoded by: hsa:6240
is: SBO:0000297
initial amount: NaN
has only substance units: false
is encoded by: hsa:6241

http://identifiers.org/biomodels.db/MODEL1310110001#_550e3469_f8b4_432c_8162_9a749a95a49d
is: Q96KN2
constant: false
initial amount: NaN
is encoded by: hsa:84735
name: CNDP1
has only substance units: false
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true

metaM HC02202 c
initial concentration: 1.0
boundary condition: false
type: Species
name: prostaglandin A1(1-)
is: CHEBI:57398
notes: FORMULA: C20H31O4 CHARGE: -1 INCHI: InChI=1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/p-1/b14-12+/t16-,17-,18+/m0/s1 EHMN_ABBREVIATION: C04685
has only substance units: false
initial amount: NaN
is: SBO:0000247
constant: false

metaM co c
initial amount: NaN
is: CHEBI:17245
type: Species
initial concentration: 1.0
name: carbon monoxide
boundary condition: false
is: HMDB01361
is: SBO:0000247
notes: FORMULA: CO CHARGE: 0 INCHI: InChI=1S/CO/c1-2 EHMN_ABBREVIATION: C00237
has only substance units: false
constant: false

metaM gtp n
constant: false
has only substance units: false
initial amount: NaN
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:37565
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 INCHI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/p-4/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044
is: SBO:0000247
name: GTP(4-)
is: HMDB01273

http://identifiers.org/biomodels.db/MODEL1310110001#_2fdecdfa_06b7_4d0e_86af_2fc6730af3af
has only substance units: false
boundary condition: true
is encoded by: hsa:1543
name: CYP1A1
constant: false
initial amount: NaN
is: SBO:0000252
is: A0N0X8
initial concentration: NaN
type: Species

metaR r1846
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110001#
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
fast: false
reversible: false
is: SBO:0000185
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction

metaR r1667
reversible: true
modifier: MODEL1310110001#
fast: false
name: Y+LAT2 Utilized transport
is described by: ECO:0000000
type: Reaction
is: SBO:0000185
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_eb0b8550_0dea_4bb3_9cfa_b3741a458209
name: ATP2B2
is encoded by: hsa:491
boundary condition: true
is: SBO:0000252
constant: false
type: Species
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: Q4J699

metaM m4mpdol U r
notes: FORMULA: C1485H2440N20O420P20 CHARGE: -20 INCHI: InChI=1S/C71H122N2O42P2/c1-30(2)13-9-14-31(3)15-10-16-32(4)17-11-18-33(5)19-12-20-34(6)21-22-101-116(96,97)115-117(98,99)114-66-45(73-36(8)81)52(88)60(42(28-79)107-66)109-65-44(72-35(7)80)51(87)61(41(27-78)106-65)110-69-59(95)62(50(86)43(108-69)29-100-67-57(93)53(89)46(82)37(23-74)102-67)111-70-64(56(92)49(85)39(25-76)104-70)113-71-63(55(91)48(84)40(26-77)105-71)112-68-58(94)54(90)47(83)38(24-75)103-68/h13,15,17,19,34,37-71,74-79,82-95H,9-12,14,16,18,20-29H2,1-8H3,(H,72,80)(H,73,81)(H,96,97)(H,98,99)/b31-15+,32-17+,33-19+/t34?,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53+,54+,55+,56+,57+,58+,59+,60-,61-,62+,63+,64+,65+,66-,67+,68-,69+,70-,71-/m1/s1
has only substance units: false
is: SBO:0000247
name: (alpha-D-Mannosyl)4-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog
initial amount: NaN
is: CHEBI:37633
boundary condition: false
type: Species
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_467b5d79_e51c_45c3_a5a0_91a3e5b44e83
has only substance units: false
is encoded by: hsa:55191
initial amount: NaN
is: SBO:0000252
boundary condition: true
type: Species
is: Q6IA69
name: NADSYN1
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_2d3b6cba_574a_4524_a430_98fa93c4e461
is: SBO:0000252
initial amount: NaN
name: SLC16A8
type: Species
has only substance units: false
is: O95907
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:23539

metaR MMMm
name: methylmalonyl-CoA mutase
type: Reaction
product: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
is described by: ECO:0000269
reversible: true
is version of: http://identifiers.org/ec-code/5.4.99.2
modifier: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (4594.1) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 5.4.99.2 Confidence Level: 4 AUTHORS: PMID:8990001 NOTES:TDV
reactant: MODEL1310110001#

metaR r0497
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 3.6.1.39 Confidence Level: 0 AUTHORS: PMID:1320895,PMID:6097526,PMID:6297538 NOTES:
reversible: true
modifier: MODEL1310110001#
name: dTTP nucleotidohydrolase Pyrimidine metabolism EC:3.6.1.39
is described by: ECO:0000000
kinetic law: MODEL1310110001#
is: SBO:0000176
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.4.2
product: MODEL1310110001#

metaR HIStiDF
modifier: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (55089.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:11342143,PMID:11414754 NOTES:SAB
type: Reaction
name: L-histidine transport via diffusion (extracellular to cytosol)
reversible: false
reactant: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#
is described by: ECO:0000269
kinetic law: MODEL1310110001#

metaM m7masnB r
has only substance units: false
type: Species
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C64H107N2O50X CHARGE: 0
is: C04946
is: SBO:0000247
constant: false
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_c7acf073_cefa_4aaa_bcdf_ad1a85938513
is: O00750
is encoded by: hsa:5287
initial amount: NaN
has only substance units: false
initial concentration: NaN
name: PIK3C2B
constant: false
boundary condition: true
type: Species
is: SBO:0000252

metaM gtp m
name: GTP
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01273
is: CHEBI:37565
constant: false
has only substance units: false
initial amount: NaN
is: C00044
type: Species
notes: FORMULA: C10H12N5O14P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00051 EHMN_ABBREVIATION: C00044

metaR NODe
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
name: NODe
product: MODEL1310110001#
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000134
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_c9b6e771_bfc8_44a0_a690_2d0696ba7e2f
is: SBO:0000252
is encoded by: hsa:8803
name: SUCLA2
is: E5KS60
has only substance units: false
initial concentration: NaN
type: Species
constant: false
boundary condition: true
initial amount: NaN

metaM na1 c
is: HMDB00588
constant: false
boundary condition: false
name: Sodium
initial concentration: 1.0
initial amount: NaN
type: Species
is: C01330
has only substance units: false
is: SBO:0000247
notes: FORMULA: Na CHARGE: 1
is: CHEBI:4541

metaR EX CE1926 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-carboxyethyl-hydroxychroman exchange
type: Reaction

metaM T4hcinnm m
is: HMDB02035
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
name: trans-4-coumarate
is: CHEBI:12876
initial amount: NaN
type: Species
notes: FORMULA: C9H7O3 CHARGE: -1 INCHI: InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/p-1/b6-3+ EHMN_ABBREVIATION: C00811

http://identifiers.org/biomodels.db/MODEL1310110001#_53705d6d_3981_44b3_be29_430ee0f97e6b
name: ARSB
initial concentration: NaN
type: Species
is: SBO:0000252
initial amount: NaN
constant: false
is: P15848
has only substance units: false
is encoded by: hsa:411
boundary condition: true

metaM ksi deg2 l
initial amount: NaN
is: CHEBI:30825
has only substance units: false
initial concentration: 1.0
is: HMDB00573
notes: FORMULA: C241H384N17O210S12 CHARGE: -13
type: Species
boundary condition: false
is: SBO:0000247
constant: false
name: keratan sulfate I, degradation product 2

metaM 2ddecdicoa m
notes: FORMULA: C33H50N7O17P3S CHARGE: -4
constant: false
initial concentration: 1.0
is: SBO:0000247
boundary condition: false
initial amount: NaN
is: HMDB11123
is: C05279
name: 2,6-dodecadienoylcoa
has only substance units: false
type: Species

metaR EX vacc LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: vaccenic acid exchange
type: Reaction

metaR DCSPTN1COAtx
reactant: MODEL1310110001#
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
name: fatty acid intracellular transport
product: MODEL1310110001#
is described by: ECO:0000000
fast: false
type: Reaction
kinetic law: MODEL1310110001#

metaR ALDD2x
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.5
is: SBO:0000176
name: aldehyde dehydrogenase (acetaldehyde, NAD)
notes: GENE_ASSOCIATION: (218.1) or (501.1) or (8854.2) or (224.1) or (222.1) or (8854.1) or (221.1) or (216.1) or (8854.3) or (223.1) or (220.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12616643 NOTES:Only acetaldehyde considered for now. See also 1.2.1.4. Wide specificity, including oxidation of D-glucuronolactone to D-glucarate. Formerly EC 1.1.1.70; r0176
is described by: ECO:0000000
product: MODEL1310110001#
fast: false
reversible: false
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.2.1.3
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.2.1.36

metaR S6TASE25ly
fast: false
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.1.6.4
is version of: http://identifiers.org/ec-code/3.2.1.23
is version of: http://identifiers.org/ec-code/3.4.16.5
reversible: true
is: SBO:0000176
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is described by: ECO:0000000

metaM glutcoa c
name: glutaryl-CoA(5-)
type: Species
constant: false
boundary condition: false
is: HMDB01339
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C26H37N7O19P3S CHARGE: -5 INCHI: InChI=1S/C26H42N7O19P3S/c1-26(2,21(39)24(40)29-7-6-15(34)28-8-9-56-17(37)5-3-4-16(35)36)11-49-55(46,47)52-54(44,45)48-10-14-20(51-53(41,42)43)19(38)25(50-14)33-13-32-18-22(27)30-12-31-23(18)33/h12-14,19-21,25,38-39H,3-11H2,1-2H3,(H,28,34)(H,29,40)(H,35,36)(H,44,45)(H,46,47)(H2,27,30,31)(H2,41,42,43)/p-5/t14-,19-,20-,21+,25-/m1/s1

http://identifiers.org/biomodels.db/MODEL1310110001#_5334b9e3_7f0f_43e9_bf38_12e012f1e32f
is encoded by: hsa:286016
has only substance units: false
type: Species
is: SBO:0000252
initial amount: NaN
boundary condition: true
name: TPI1P2
initial concentration: NaN
constant: false

metaR UAGALDP
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Aminosugar metabolism EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD
is: SBO:0000176
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110001#
fast: false
name: UDP-N-acetylgalactosamine diphosphorylase
kinetic law: MODEL1310110001#
product: MODEL1310110001#

metaM c3dc c
boundary condition: false
is: HMDB02095
name: malonyl carnitine
is: SBO:0000247
initial concentration: 1.0
type: Species
has only substance units: false
initial amount: NaN
constant: false
notes: FORMULA: C10H16NO6 CHARGE: -1

http://identifiers.org/biomodels.db/MODEL1310110001#_30a6a3d1_6aa9_4044_a9e8_f8ab5f38ad73
boundary condition: true
is encoded by: hsa:217
initial concentration: NaN
is: P05091
has only substance units: false
name: ALDH2
type: Species
is: SBO:0000252
initial amount: NaN
constant: false

metaR r1997
fast: false
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110001#
is described by: ECO:0000000
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110001#_80380c58_e12b_4db8_bc4b_c87c889f9cdb
is: P22392
type: Species
has only substance units: false
name: NME2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:4831
initial amount: NaN
constant: false
boundary condition: true

metaR DURAD2
reactant: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
kinetic law: MODEL1310110001#
fast: false
is described by: ECO:0000269
product: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.1.2
name: dihydrothymin dehydrogenase (NADP)
type: Reaction
reversible: true

metaR UMPK6n
is: SBO:0000176
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.14
kinetic law: MODEL1310110001#
type: Reaction
fast: false
product: MODEL1310110001#
reversible: true
name: UMP kinase (dCTP),nuclear

http://identifiers.org/biomodels.db/MODEL1310110001#_42f3dc5a_1d10_4434_a4ed_689bf5f50e90
initial concentration: NaN
has part: P11177
type: Species
is encoded by: hsa:1737
is encoded by: hsa:5161
initial amount: NaN
boundary condition: true
has only substance units: false
name: DLAT:DLD:PDHA2:PDHB:PDHX
has part: P29803
is: SBO:0000297
has part: Q86YI5
is encoded by: hsa:5162
constant: false

metaM mi14p c
type: Species
notes: FORMULA: C6H10O12P2 CHARGE: -4 INCHI: InChI=1S/C6H14O12P2/c7-1-2(8)6(18-20(14,15)16)4(10)3(9)5(1)17-19(11,12)13/h1-10H,(H2,11,12,13)(H2,14,15,16)/p-4/t1-,2-,3-,4+,5+,6+/m1/s1 EHMN_ABBREVIATION: C01220
constant: false
initial amount: NaN
is: SBO:0000247
name: (1R,2R,3R,4R,5R,6S)-2,3,5,6-tetrahydroxy-4-(phosphonatooxy)cyclohexyl phosphate
boundary condition: false
is: CHEBI:58282
has only substance units: false
is: HMDB00968
initial concentration: 1.0

metaR DHCRD2
is: SBO:0000176
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:9188692 NOTES:NJ
reactant: MODEL1310110001#
product: MODEL1310110001#
fast: false
type: Reaction
name: dihydroceramide desaturase
kinetic law: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_d89f1632_649a_4d4d_8130_c3dff51494df
has only substance units: false
initial amount: NaN
boundary condition: true
is: SBO:0000252
name: SLC8A3
constant: false
is encoded by: hsa:6547
type: Species
initial concentration: NaN

metaR RE0915E
notes: GENE_ASSOCIATION: (280.1) or (84569.1) or (276.1) or (277.1) or (278.1) or (279.1) or (276.1) or (277.1) or (278.1) or (279.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.1 Confidence Level: 0 AUTHORS: PMID:385176,PMID:8528071,PMID:890964 NOTES:
is version of: http://identifiers.org/ec-code/3.2.1.17
modifier: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000176
name: RE0915
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.1
reversible: true
fast: false

metaR PMANM
fast: false
name: phosphomannomutase
type: Reaction
notes: GENE_ASSOCIATION: (5372.1) or (55276.1) or (5373.1) SUBSYSTEM: Fructose and mannose metabolism EC Number: 5.4.2.8 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reversible: true
modifier: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/5.4.2.2
is version of: http://identifiers.org/ec-code/5.4.2.8
reactant: MODEL1310110001#

metaR EX arg L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Arginine exchange
type: Reaction

metaM 5tedtricoa m
constant: false
name: 5,8,11-tetradecatrienoylcoa
is: SBO:0000247
has only substance units: false
is: HMDB02288
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C35H52N7O17P3S CHARGE: -4
type: Species
initial amount: NaN

metaM cpppg3 c
is: C03263
initial amount: NaN
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:57309
name: Coproporphyrinogen III
is: SBO:0000247
notes: FORMULA: C36H40N4O8 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01085 EHMN_ABBREVIATION: C03263
type: Species
is: HMDB01261

http://identifiers.org/biomodels.db/MODEL1310110001#_23958fd8_341c_40d2_b4e8_288d242e3b7d
initial concentration: NaN
is: G3XAJ0
is encoded by: hsa:80724
type: Species
boundary condition: true
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
name: ACAD10

metaR AICART
kinetic law: MODEL1310110001#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.1.2.3
reactant: MODEL1310110001#
name: phosphoribosylaminoimidazolecarboxamide formyltransferase
modifier: MODEL1310110001#
reversible: true
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (471.1) SUBSYSTEM: Purine synthesis EC Number: 2.1.2.3 Confidence Level: 4 AUTHORS: PMID:11948179,PMID:14966129,PMID:9378707 NOTES:
product: MODEL1310110001#
fast: false

metaR GLYPHEHYc
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 1 AUTHORS: most probable reaction. added during gap filling. NOTES:most probable reaction. added during gap filling.
product: MODEL1310110001#
type: Reaction
is described by: ECO:0000134
fast: false
is: SBO:0000176
name: hydrolysis of glycylphenylalanine

metaM cholcoads x
constant: false
has only substance units: false
type: Species
boundary condition: false
is: HMDB06889
notes: FORMULA: C48H74N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H78N7O20P3S/c1-25(29-10-11-30-36-31(20-34(58)48(29,30)6)47(5)14-12-28(56)18-27(47)19-32(36)57)8-7-9-26(2)45(63)79-17-16-50-35(59)13-15-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-33-39(74-76(64,65)66)38(60)44(73-33)55-24-54-37-41(49)52-23-53-42(37)55/h9,23-25,27-34,36,38-40,44,56-58,60-61H,7-8,10-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,27+,28-,29-,30+,31+,32-,33-,34+,36+,38-,39-,40+,44-,47+,48-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01466 EHMN_ABBREVIATION: C05460
is: CHEBI:27505
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN

metaM fprica c
notes: FORMULA: C10H13N4O9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC01344 EHMN_ABBREVIATION: C04734
initial amount: NaN
boundary condition: false
is: C04734
is: SBO:0000247
type: Species
constant: false
is: CHEBI:58467
is: HMDB01439
initial concentration: 1.0
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide
has only substance units: false

metaR DM atp c
reversible: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: AUTHORS: NOTES:
is described by: ECO:0000134
name: DM_atp(c)
type: Reaction
is: SBO:0000176

metaM 1pyr5c c
is: C03912
boundary condition: false
notes: FORMULA: C5H6NO2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC01199 EHMN_ABBREVIATION: C03912
initial amount: NaN
constant: false
has only substance units: false
is: HMDB01301
is: CHEBI:15893
name: 1-Pyrroline-5-carboxylate
is: SBO:0000247
initial concentration: 1.0
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_4538f264_e0df_450b_a606_545ee2ab274f
is: SBO:0000252
name: GUCY2D
is: Q02846
initial amount: NaN
type: Species
is encoded by: hsa:3000
has only substance units: false
constant: false
initial concentration: NaN
boundary condition: true

metaM gdp n
is: HMDB01201
initial concentration: 1.0
is: SBO:0000247
initial amount: NaN
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 INCHI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/p-3/t3-,5-,6-,9-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
has only substance units: false
constant: false
name: GDP(3-)
type: Species
is: CHEBI:58189
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_2cf542b9_0e0d_4d89_b568_2c97b8eda90f
is encoded by: hsa:5277
is: P37287
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
is: SBO:0000252
initial concentration: NaN
name: PIGA

metaR KYNATESYN
notes: GENE_ASSOCIATION: SUBSYSTEM: Tryptophan metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:15016471,PMID:16008534 NOTES:SAB name is a guess
type: Reaction
is described by: ECO:0000000
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000176
name: 4-(2-Aminophenyl)-2,4-dioxobutanoate dehydratase
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110001#_5fb88d90_f748_4e50_a076_8453ebf334ae
boundary condition: true
initial amount: NaN
is: SBO:0000252
has only substance units: false
type: Species
name: _AI640625_1_c
initial concentration: NaN
is encoded by: hsa:AI640625
constant: false

metaR C4x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: esterification of butyrylcoa to butyrylcarnitine for transport
type: Reaction

metaR FAOXC226C205m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C20:5)m
type: Reaction

metaM bhb m
boundary condition: false
constant: false
is: HMDB00011
type: Species
is: SBO:0000247
name: (R)-3-hydroxybutyrate
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(5)2-4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00661 EHMN_ABBREVIATION: C01089
initial concentration: 1.0
is: CHEBI:10983

metaM cs a deg4 l
is: SBO:0000247
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 4
type: Species
is: HMDB01354
boundary condition: false
initial amount: NaN
is: CHEBI:57455
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C31H49NO29S CHARGE: -2

http://identifiers.org/biomodels.db/MODEL1310110001#_0a41e9e6_bd79_4707_8104_3e54a63cddb3
constant: false
is: SBO:0000252
is: Q99624
initial amount: NaN
initial concentration: NaN
name: SLC38A3
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:10991

http://identifiers.org/biomodels.db/MODEL1310110001#_5958064b_c3b5_4124_bd1d_0d7dce042e0f
constant: false
boundary condition: true
initial amount: NaN
initial concentration: NaN
is: Q9H008
type: Species
has only substance units: false
is encoded by: hsa:64077
is: SBO:0000252
name: LHPP

http://identifiers.org/biomodels.db/MODEL1310110001#_cb47f56a_2560_40db_9941_7ac8c8b09daa
name: GBA
initial concentration: NaN
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
is: P04062
is encoded by: hsa:2629
type: Species
is: SBO:0000252

metaM hepcoa m
constant: false
name: heptanoylcoa
is: HMDB12969
notes: FORMULA: C28H44N7O17P3S CHARGE: -4
initial amount: NaN
has only substance units: false
initial concentration: 1.0
type: Species
boundary condition: false
is: SBO:0000247

metaM c3dc e
boundary condition: false
type: Species
initial concentration: 1.0
name: malonyl carnitine
initial amount: NaN
constant: false
has only substance units: false
notes: FORMULA: C10H16NO6 CHARGE: -1
is: SBO:0000247
is: HMDB02095

http://identifiers.org/biomodels.db/MODEL1310110001#_f1f41da4_62f4_4a3a_821e_4fc39483a7ba
type: Species
is encoded by: hsa:5336
initial concentration: NaN
is: P16885
initial amount: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
name: PLCG2
constant: false

metaM gdp m
type: Species
is: C00035
name: GDP
is: SBO:0000247
is: CHEBI:58189
boundary condition: false
initial amount: NaN
has only substance units: false
notes: FORMULA: C10H12N5O11P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00043 EHMN_ABBREVIATION: C00035
constant: false
is: HMDB01201
initial concentration: 1.0

metaM dodecanac c
initial amount: NaN
type: Species
initial concentration: 1.0
is: SBO:0000247
name: Dodecanedioic acid
notes: FORMULA: C12H20O4 CHARGE: -2
is: HMDB00623
constant: false
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_bf19f6b8_ef24_4422_bbd3_713eb2728232
initial amount: NaN
name: ENTPD2
constant: false
is: Q5SPY7
is: SBO:0000252
type: Species
is encoded by: hsa:954
boundary condition: true
has only substance units: false
initial concentration: NaN

metaM nh4 c
has only substance units: false
is: HMDB00051
constant: false
is: C01342
boundary condition: false
notes: FORMULA: H4N CHARGE: 1 HEPATONET_1.0_ABBREVIATION: HC00765 EHMN_ABBREVIATION: C01342
is: SBO:0000247
is: CHEBI:28938
initial concentration: 1.0
initial amount: NaN
name: Ammonium
type: Species

metaR 3SALATAim
type: Reaction
kinetic law: MODEL1310110001#
reversible: false
is: SBO:0000176
reactant: MODEL1310110001#
name: 3-sulfino-alanine transaminase (irreversible), mitochondrial
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 2.6.1.1 Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM. activity measured in rat, 3-sulfinoalanine is substrate found in human brain
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
product: MODEL1310110001#
modifier: MODEL1310110001#

metaM gd3 hs g
is: CHEBI:28424
initial amount: NaN
is: SBO:0000247
constant: false
has only substance units: false
initial concentration: 1.0
type: Species
notes: FORMULA: C52H88N3O28FULLRCO CHARGE: -2
boundary condition: false
name: GD3

http://identifiers.org/biomodels.db/MODEL1310110001#_6145738c_f33c_4154_af98_0c6962d2a53e
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
is: SBO:0000252
is encoded by: hsa:AI924226
name: _AI924226_1_m
initial concentration: NaN

metaR 34HPPte
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
fast: false
is described by: ECO:0000134
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
type: Reaction
name: Transport of 3-(4-hydroxyphenyl)pyruvate

metaR r0784
name: xylitol:NAD oxidoreductase Pentose and glucuronate interconversions EC:1.1.1.15
kinetic law: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (AA526438.1) or (H17063.1) or (51102.1) or (55825.1) SUBSYSTEM: Pentose phosphate pathway EC Number: 1.1.1.15 Confidence Level: 0 AUTHORS: PMID:13373783 NOTES:
is described by: ECO:0000000
product: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.3.1.38
type: Reaction
is: SBO:0000176
reversible: true

metaR r0394
fast: false
type: Reaction
is described by: ECO:0000000
name: Xanthine:NAD+ oxidoreductase Purine metabolism EC:1.17.1.4
reversible: true
is: SBO:0000176
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.1.4 Confidence Level: 0 AUTHORS: PMID:2713424,PMID:8248161 NOTES:
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_6baaa725_6a93_4143_b359_004395366e5e
is: SBO:0000252
initial concentration: NaN
type: Species
name: PIGS
boundary condition: true
is: Q8NBL9
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:94005

http://identifiers.org/biomodels.db/MODEL1310110001#_324b2ab6_6473_463d_a58c_da855baa2513
has part: P56134
initial concentration: NaN
is encoded by: hsa:522
is encoded by: hsa:9551
boundary condition: true
type: Species
is: SBO:0000297
constant: false
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
initial amount: NaN

metaM 10fthf5glu e
initial amount: NaN
type: Species
notes: FORMULA: C40H45N11O19 CHARGE: -6
is: HMDB00108
has only substance units: false
boundary condition: false
initial concentration: 1.0
name: 10-formyltetrahydrofolate-[Glu](5)
is: CHEBI:16236
constant: false
is: SBO:0000247

metaR 3MOBt2im
kinetic law: MODEL1310110001#
product: MODEL1310110001#
fast: false
type: Reaction
name: 3-methyl-2-oxobutanoate mitochondrial transport via proton symport
reactant: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:8428987 NOTES:MM
is described by: ECO:0000000
reversible: false

metaR r2362
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
type: Reaction
reactant: MODEL1310110001#
reversible: true
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
fast: false
product: MODEL1310110001#
is described by: ECO:0000000

metaR TSTSTERONESte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism - presumed excretion of sulfonated testosterone NJ
name: sulfonated testosterone transport
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
type: Reaction
is: SBO:0000185
fast: false
product: MODEL1310110001#
is described by: ECO:0000000

metaR SFCYSe
fast: false
is described by: ECO:0000134
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES:sulfocysteine is exfreted in urine
name: Exit of sulfocysteine into extra-cellular space
product: MODEL1310110001#
is: SBO:0000185
type: Reaction
reversible: true

metaM cit e
type: Species
is: SBO:0000247
name: citrate(3-)
is: CHEBI:16947
initial concentration: 1.0
notes: FORMULA: C6H5O7 CHARGE: -3 INCHI: InChI=1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/p-3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
boundary condition: false
initial amount: NaN
is: HMDB00094
has only substance units: false
constant: false

metaR r0395
reversible: true
reactant: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Nucleotide interconversion EC Number: 1.17.3.2 Confidence Level: 0 AUTHORS: PMID:11993848,PMID:1643670,PMID:3010873,PMID:8343533 NOTES:
name: Hypoxanthine:oxygen oxidoreductase Purine metabolism EC:1.17.3.2
product: MODEL1310110001#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_7154a0d4_d8f5_40a4_88e9_92d8bcf67215
initial amount: NaN
is encoded by: hsa:9194
is: Q8NEM3
type: Species
constant: false
has only substance units: false
boundary condition: true
name: SLC16A7
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_ce492a42_de8e_4fe7_81af_767833e51d73
has only substance units: false
is: SBO:0000252
is: Q03393
name: PTS
is encoded by: hsa:5805
initial amount: NaN
type: Species
initial concentration: NaN
boundary condition: true
constant: false

metaR GHMT2rm
type: Reaction
is: SBO:0000176
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6472.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 2.1.2.1 Confidence Level: 4 AUTHORS: PMID:8505317,PMID:8611185,PMID:9038835 NOTES:NCD
kinetic law: MODEL1310110001#
reversible: true
product: MODEL1310110001#
name: glycine hydroxymethyltransferase, reversible, mitochondrial
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.1.2.1
reactant: MODEL1310110001#

metaM h e
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
initial concentration: 1.0
is: C00080
notes: FORMULA: H CHARGE: 1 INCHI: "
is: http://identifiers.org/pubchem.compound/3380
boundary condition: false
constant: false
is: CHEBI:24636
name: proton

metaM c51crn c
boundary condition: false
initial amount: NaN
is: HMDB02366
name: tiglyl carnitine
type: Species
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false
notes: FORMULA: C12H21NO4 CHARGE: 0

http://identifiers.org/biomodels.db/MODEL1310110001#_b57a1fd9_c04d_488d_8f55_6f8ecf0e1e70
is: Q9BXS1
constant: false
type: Species
is: SBO:0000252
boundary condition: true
has only substance units: false
initial concentration: NaN
name: IDI2
initial amount: NaN
is encoded by: hsa:91734

http://identifiers.org/biomodels.db/MODEL1310110001#_bd6343fd_5738_44f0_81f1_ae62625792b6
initial concentration: NaN
is encoded by: hsa:4514
has only substance units: false
is: P00414
type: Species
initial amount: NaN
boundary condition: true
name: COX3
is: SBO:0000252
constant: false

metaR GGH 6THFe
reactant: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (8836.1) SUBSYSTEM: Folate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:11375437,PMID:2867095,PMID:9614206 NOTES:REMOVES EITHER ONE OR TWO GLUTAMYL RESIDUES WITH A REACTION (WILL ONLY REPRESENT 1) IT
is described by: ECO:0000000
kinetic law: MODEL1310110001#
fast: false
name: Gamma-glutamyl hydrolase (6THF), extracellular
is version of: http://identifiers.org/ec-code/3.4.19.9
type: Reaction
reversible: false
modifier: MODEL1310110001#

metaR r2363
is: SBO:0000185
is described by: ECO:0000000
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
product: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_8ed348e0_31b2_4bfb_9470_4de17e444391
is: SBO:0000252
name: DGUOK
initial amount: NaN
is encoded by: hsa:1716
boundary condition: true
initial concentration: NaN
type: Species
has only substance units: false
is: E5KSL6
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_fe29168a_2419_41a0_ba8a_115481e659e1
type: Species
has only substance units: false
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:5471
boundary condition: true
initial concentration: NaN
constant: false
name: PPAT
is: Q06203

http://identifiers.org/biomodels.db/MODEL1310110001#_6b8d79d9_c1be_4b29_b4f7_755f7b183f48
name: SLC34A3
boundary condition: true
constant: false
initial concentration: NaN
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:142680
is: Q8N130
initial amount: NaN

metaR A4GNT2g
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (51146.1) SUBSYSTEM: O-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10430883 NOTES:EC 2.4.1.- NCD
name: alpha 1,4-N-acetylglucosaminyltransferase, Golgi apparatus
fast: false
modifier: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
reversible: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_b728d26d_6a5e_4d33_893c_ac6a804bd12b
initial concentration: NaN
has only substance units: false
name: GUCY1A2
boundary condition: true
constant: false
type: Species
initial amount: NaN
is encoded by: hsa:2977
is: SBO:0000252
is: P33402

metaR PPBNGS
is described by: ECO:0000269
type: Reaction
is version of: http://identifiers.org/ec-code/4.2.1.24
is: SBO:0000176
notes: GENE_ASSOCIATION: (210.1) or (210.2) SUBSYSTEM: Heme synthesis EC Number: 4.2.1.24 Confidence Level: 4 AUTHORS: NOTES:
name: porphobilinogen synthase
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
reversible: false
fast: false

metaR MCLACCYSR
type: Reaction
kinetic law: MODEL1310110001#
name: 3-mercaptolactate:cysteine reductase
fast: false
reactant: MODEL1310110001#
reversible: false
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:6945862 NOTES:MM
is: SBO:0000176
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_84352f4f_ac9a_419f_91f8_095119935574
name: SLC8A3
has only substance units: false
is encoded by: hsa:6547
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
is: B3KU59

metaR HEDCECRNe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxyhexadecenoyl carnitine into extra cellular space
type: Reaction

metaR r0392
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
type: Reaction
is described by: ECO:0000000
reversible: true
product: MODEL1310110001#
is: SBO:0000176
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
kinetic law: MODEL1310110001#

metaR r2360
fast: false
is described by: ECO:0000000
reactant: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
reversible: true
is: SBO:0000185
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110001#
product: MODEL1310110001#

metaR SUCCt2m
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (1468.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV
type: Reaction
modifier: MODEL1310110001#
name: succinate transport, mitochondrial
reversible: true
reactant: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#
fast: false
is described by: ECO:0000269

metaM HC01231 m
is: SBO:0000247
name: N-[(R)-pantothenoyl]-L-cysteinate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
is: CHEBI:58480
boundary condition: false
type: Species
initial amount: NaN
constant: false

metaR C161CPT1
modifier: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.21
fast: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:TDV
reversible: false
product: MODEL1310110001#
reactant: MODEL1310110001#
name: production of palmitoleoylcarnitine
is: SBO:0000176

metaM 3aib D c
constant: false
boundary condition: false
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
name: D-3-Amino-isobutanoate
is: SBO:0000247
type: Species
has only substance units: false
initial concentration: 1.0
is: C03265
is: HMDB02299
initial amount: NaN

metaR S6TASE20ly
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.6.14
is described by: ECO:0000000
reactant: MODEL1310110001#
is: SBO:0000176
fast: false
type: Reaction
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
name: N-acetylglucosamine-6-sulfatase, lysosomal
notes: GENE_ASSOCIATION: (2799.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.14 Confidence Level: 4 AUTHORS: PMID:3196333,PMID:3689314,PMID:3689315 NOTES:NCD
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_efb3bb29_a9f2_4e9e_b95d_61bdceaa8836
is encoded by: hsa:2678
initial amount: NaN
name: GGT1
initial concentration: NaN
is: SBO:0000252
has only substance units: false
boundary condition: true
type: Species
constant: false
is: P19440

metaR r1088
reactant: MODEL1310110001#
is: SBO:0000185
type: Reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
is described by: ECO:0000000
name: Active transport
fast: false
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_7dd3c8ce_3f9d_4f58_a34c_c7eb2f683401
name: TAT
is encoded by: hsa:6898
is: P17735
type: Species
initial amount: NaN
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaR PI45P5P
kinetic law: MODEL1310110001#
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase
is version of: http://identifiers.org/ec-code/3.1.3.36
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000176
fast: false
modifier: MODEL1310110001#
reversible: false
notes: GENE_ASSOCIATION: (8867.1) or (56623.1) or (4952.1) or (8871.1) or (8867.2) or (4952.2) or (3633.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.36 Confidence Level: 4 AUTHORS: PMID:10764818,PMID:12915445,PMID:7721860,PMID:7761412 NOTES:NCD
product: MODEL1310110001#
is described by: ECO:0000000

metaR r0393
type: Reaction
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
is: SBO:0000176
fast: false
modifier: MODEL1310110001#
name: D-Glyceraldehyde:NAD+ oxidoreductase Glycerolipid metabolism EC:1.2.1.3
reversible: false
is version of: http://identifiers.org/ec-code/2.7.1.74
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Unassigned EC Number: 1.2.1.3 Confidence Level: 0 AUTHORS: PMID:12705826,PMID:170276,PMID:6189823,PMID:6285247,PMID:8155713 NOTES:
product: MODEL1310110001#

metaR r0787
is version of: http://identifiers.org/ec-code/1.1.1.1
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#
fast: false
name: 3-sn-phosphatidate phosphohydrolase Sphingolipid metabolism EC:3.1.3.4
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (124.1) or (125.1) or (128.1) or (130.1) or (131.1) or (AI291895.1) or (M68895.1) or (X63359.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 3.1.3.4 Confidence Level: 0 AUTHORS: PMID:7575445 NOTES:
product: MODEL1310110001#
is: SBO:0000176

metaR C161CPT2
kinetic law: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110001#
name: transport of Hexadecenoyl-CoA into mitochondrial matrix
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
modifier: MODEL1310110001#
reversible: false

metaM spmd e
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
has only substance units: false
initial amount: NaN
type: Species
name: Spermidine
is: CHEBI:57834
is: HMDB01257
is: SBO:0000247
initial concentration: 1.0
constant: false
boundary condition: false
is: C00315

metaM h g
constant: false
boundary condition: false
is: CHEBI:24636
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: H CHARGE: 1 INCHI: InChI=1S/p+1/i/hH HEPATONET_1.0_ABBREVIATION: HC00083 EHMN_ABBREVIATION: C00080
type: Species
name: proton
has only substance units: false
initial amount: NaN

metaR r2361
reactant: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false
product: MODEL1310110001#
type: Reaction
reversible: true
kinetic law: MODEL1310110001#

metaM xylu L c
type: Species
is: SBO:0000247
is: HMDB00751
initial amount: NaN
is: CHEBI:17399
has only substance units: false
notes: FORMULA: C5H10O5 CHARGE: 0 INCHI: InChI=1S/C5H10O5/c6-1-3(8)5(10)4(9)2-7/h3,5-8,10H,1-2H2/t3-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00267
initial concentration: 1.0
boundary condition: false
constant: false
name: L-xylulose

metaR LEUKTRF4t
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
type: Reaction
fast: false
name: leukotriene F4 transport
reactant: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reversible: true

metaR G3PD1
fast: false
product: MODEL1310110001#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110001#
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (2819.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 1.1.1.94 Confidence Level: 4 AUTHORS: PMID:11385633,PMID:7772607 NOTES:NAD-specific; see also G3PD2
is version of: http://identifiers.org/ec-code/1.1.1.8
name: glycerol-3-phosphate dehydrogenase (NAD)
reversible: true
is described by: ECO:0000269

metaR O16G2e
is described by: ECO:0000000
name: oligo-1,6-glucosidase (strch2 ->strch3), extracellular
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.10
type: Reaction
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (6476.1) SUBSYSTEM: Starch and sucrose metabolism EC Number: 3.2.1.10 Confidence Level: 0 AUTHORS: NOTES:NCD
product: MODEL1310110001#
is: SBO:0000176
reversible: false

metaM glyc R m
is: HMDB00139
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
is: CHEBI:16659
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: false
name: D-glycerate
initial concentration: 1.0
is: SBO:0000247

metaR FACOAL2042
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.2.1.3
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000
name: fatty-acid--CoA ligase
notes: GENE_ASSOCIATION: (2180.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:rev version so additional rxn doesn't need to be added to "unload" AA alternate to arachidonic acid (n-3 rather than n-6) NJ
reversible: true
type: Reaction
kinetic law: MODEL1310110001#
fast: false
is: SBO:0000176

metaR DCSPTN1CPT2
reversible: false
is version of: http://identifiers.org/ec-code/2.3.1.21
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
name: carnitine transferase
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ

metaR RETFA
reversible: false
type: Reaction
name: retinol acyltransferase
notes: GENE_ASSOCIATION: SUBSYSTEM: Vitamin A metabolism EC Number: 2.3.1.76 Confidence Level: 2 AUTHORS: PMID:1503811 NOTES:IT
reactant: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
is described by: ECO:0000000

metaR ESTRADIOLt
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
type: Reaction
fast: false
name: estradiol transport
reversible: true

metaR FAOXC101C102x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10:1-->C10:2)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_06ba8f76_cff7_41a5_a270_28cdd388a513
is encoded by: hsa:50700
boundary condition: true
name: RDH8
is: SBO:0000252
initial amount: NaN
is: Q9NYR8
has only substance units: false
type: Species
initial concentration: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_2f888699_768f_4777_8b9f_533bee0590f6
is: O15382
constant: false
boundary condition: true
is: SBO:0000252
type: Species
initial amount: NaN
name: BCAT2
is encoded by: hsa:587
initial concentration: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_9ec4982b_05e2_42b4_b310_e83bc6293459
name: ABCC3
type: Species
is: Q86VN9
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8714

metaM sebcoa c
type: Species
name: sebacoylcoa
initial amount: NaN
boundary condition: false
is: HMDB00651
initial concentration: 1.0
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
constant: false
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_1297c4e7_e4e4_478b_a4e2_083f502e83e4
has only substance units: false
is: P49619
type: Species
is: SBO:0000252
constant: false
initial concentration: NaN
boundary condition: true
initial amount: NaN
is encoded by: hsa:1608
name: DGKG

metaR C161CRN2t
reactant: MODEL1310110001#
product: MODEL1310110001#
fast: false
reversible: false
name: C161 transport into the mitochondria
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is: SBO:0000185
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction

metaR r0788
product: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
reversible: true
name: S-Adenosyl-L-methionine:methylethanolamine phosphate N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.14.13.15
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
modifier: MODEL1310110001#

metaM c81coa c
initial amount: NaN
name: octenoylcoa
type: Species
is: HMDB03949
has only substance units: false
boundary condition: false
is: C05276
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C29H44N7O17P3S CHARGE: -4

metaR DCSPTN1CPT1
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#
name: carnitine O-palmitoyltransferase
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
fast: false
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110001#
is described by: ECO:0000269
reversible: false
type: Reaction

metaM 3hexdtricoa m
initial amount: NaN
boundary condition: false
is: HMDB02288
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: SBO:0000247
name: 3,7,10-hexadecatrienoylcoa
constant: false
type: Species
has only substance units: false
initial concentration: 1.0

metaR Htr
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion NJ
kinetic law: MODEL1310110001#
name: H transporter, endoplasmic reticulum
fast: false
is: SBO:0000185
is described by: ECO:0000000

metaM 3bcrn c
constant: false
is: HMDB04047
has only substance units: false
type: Species
is: C14143
name: 3-hydroxy butyryl carnitine
boundary condition: false
notes: FORMULA: C11H21NO5 CHARGE: 0
initial amount: NaN
initial concentration: 1.0
is: SBO:0000247

metaR SPMTDe
product: MODEL1310110001#
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
is: SBO:0000185
reversible: true
name: SPMTDe
fast: false

metaR r0399
reactant: MODEL1310110001#
is: SBO:0000176
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating) Phenylalanine, tyrosine and tryptophan biosynthesis EC:1.14.16.1
is version of: http://identifiers.org/ec-code/1.2.4.2
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Tetrahydrobiopterin metabolism EC Number: 1.14.16.1 Confidence Level: 0 AUTHORS: PMID:3298976,PMID:4074362 NOTES:
fast: false
product: MODEL1310110001#
type: Reaction
reversible: true
is described by: ECO:0000000

metaR C4DCCACT
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of succinyl carnitine into cytosol
type: Reaction

metaR ADNCYC
is version of: http://identifiers.org/ec-code/4.6.1.1
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (112.1) or (55811.1) or (109.1) or (112.2) or (114.1) or (108.1) or (113.1) or (107.1) or (196883.1) or (115.1) or (111.1) SUBSYSTEM: Nucleotide interconversion EC Number: 4.6.1.1 Confidence Level: 4 AUTHORS: PMID:10481931,PMID:11299302,PMID:11423534,PMID:11840511,PMID:12503609,PMID:12609998,PMID:12623444,PMID:1427768,PMID:14996950,PMID:15547246,PMID:7860067,PMID:7959689,PMID:8076676 NOTES:JLR
is described by: ECO:0000269
product: MODEL1310110001#
name: adenylate cyclase
type: Reaction
reversible: false
is: SBO:0000176
modifier: MODEL1310110001#

metaM ksi pre29 g
is: CHEBI:28067
has only substance units: false
initial concentration: 1.0
name: keratan sulfate I biosynthesis, precursor 29
constant: false
initial amount: NaN
notes: FORMULA: C213H340N15O179S9X CHARGE: -10
is: SBO:0000247
type: Species
boundary condition: false

metaM lnlc c
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
name: linoleate
is: HMDB00673
boundary condition: false
constant: false
has only substance units: false
is: CHEBI:30245
type: Species

metaM 3hexdcoa c
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
name: 3-hydroxyhexadecanoylcoa
is: SBO:0000247
constant: false
initial concentration: 1.0
boundary condition: false
is: C05258
is: HMDB03932
has only substance units: false
type: Species
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_1007e6af_c2d5_4ca6_b782_f4678a0887f5
type: Species
is: SBO:0000252
is encoded by: hsa:6713
is: Q5HYI4
has only substance units: false
boundary condition: true
constant: false
name: SQLE
initial amount: NaN
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_483763ea_9a55_4a59_99af_67cc641e54ed
is: Q9BX95
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
name: SGPP1
initial amount: NaN
is encoded by: hsa:81537

metaR r0789
is version of: http://identifiers.org/ec-code/1.14.13.15
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: (1593.1) SUBSYSTEM: Sphingolipid metabolism EC Number: 2.1.1.103 Confidence Level: 0 AUTHORS: PMID:2403362 NOTES:
type: Reaction
is described by: ECO:0000000
name: S-Adenosyl-L-methionine:phosphodimethylethanolamine N-methyltransferase Glycerophospholipid metabolism EC:2.1.1.103
product: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_4b2ca75c_7f3a_4a84_96b1_482896b70c88
has only substance units: false
is: SBO:0000252
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: PLCB4
is: E2QRH8
is encoded by: hsa:5332
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_16e66a2e_7c9f_49fd_8d10_a85ebc93e362
type: Species
initial concentration: NaN
has only substance units: false
is encoded by: hsa:223
is: P49189
name: ALDH9A1
constant: false
initial amount: NaN
boundary condition: true
is: SBO:0000252

metaR EX dtdp LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ({[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphonato}oxy)phosphonate exchange
type: Reaction

metaR q10tm
kinetic law: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:
reactant: MODEL1310110001#
fast: false
is: SBO:0000185
name: transport of ubiquinone into mitochondria
is described by: ECO:0000134
product: MODEL1310110001#
type: Reaction

metaM oxa m
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:30623
constant: false
is: HMDB02329
notes: FORMULA: C2O4 CHARGE: -2 INCHI: InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2 HEPATONET_1.0_ABBREVIATION: HC00195 EHMN_ABBREVIATION: C00209
initial amount: NaN
type: Species
has only substance units: false
name: oxalate(2-)
boundary condition: false

metaR MM6B2g
type: Reaction
product: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000000
fast: false
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase, Golgi apparatus
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (4121.1) or (57134.1) or (10905.1) SUBSYSTEM: N-glycan synthesis EC Number: 3.2.1.113 Confidence Level: 0 AUTHORS: PMID:10915796,PMID:9592125 NOTES:NCD
modifier: MODEL1310110001#
reversible: false
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.113

metaR PYDXNK
fast: false
is: SBO:0000176
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (8566.1) SUBSYSTEM: Vitamin B6 metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
reversible: false
product: MODEL1310110001#
name: pyridoxine kinase
modifier: MODEL1310110001#
is described by: ECO:0000269
type: Reaction
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.1.35

metaM thcholoylcoa x
has only substance units: false
is: CHEBI:27403
type: Species
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C48H76N7O20P3S CHARGE: -4 INCHI: InChI=1S/C48H80N7O20P3S/c1-25(29-8-9-30-36-31(12-15-48(29,30)6)47(5)14-11-28(56)19-27(47)20-33(36)58)7-10-32(57)26(2)45(63)79-18-17-50-35(59)13-16-51-43(62)40(61)46(3,4)22-72-78(69,70)75-77(67,68)71-21-34-39(74-76(64,65)66)38(60)44(73-34)55-24-54-37-41(49)52-23-53-42(37)55/h23-34,36,38-40,44,56-58,60-61H,7-22H2,1-6H3,(H,50,59)(H,51,62)(H,67,68)(H,69,70)(H2,49,52,53)(H2,64,65,66)/t25-,26?,27+,28-,29-,30+,31+,32?,33-,34-,36+,38-,39-,40+,44-,47+,48-/m1/s1
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA
boundary condition: false
is: HMDB12456

metaR 3AIBTm
is: SBO:0000176
kinetic law: MODEL1310110001#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.19
type: Reaction
modifier: MODEL1310110001#
fast: false
product: MODEL1310110001#
reversible: true
name: L-3-aminoisobutyrate transaminase, mitochondrial
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 2.6.19.4 Confidence Level: 2 AUTHORS: NOTES:NCD
reactant: MODEL1310110001#

metaR RETH
is: SBO:0000176
reversible: false
modifier: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (8228.1) SUBSYSTEM: Vitamin A metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:1503811,PMID:15955102 NOTES:IT
reactant: MODEL1310110001#
name: retinyl ester hydrolase
is version of: http://identifiers.org/ec-code/3.1.1.3
product: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_552fed0f_4530_4aea_a419_0e26a56c170d
name: _AV713053_1_m
type: Species
has only substance units: false
is encoded by: hsa:AV713053
is: SBO:0000252
initial amount: NaN
constant: false
initial concentration: NaN
boundary condition: true

metaR GGLUCT
kinetic law: MODEL1310110001#
product: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.2.4
type: Reaction
is described by: ECO:0000269
reversible: false
name: gamma-glutamylcyclotransferase
is: SBO:0000185
notes: GENE_ASSOCIATION: (79017.1) SUBSYSTEM: Glutathione metabolism EC Number: 2.3.2.4 Confidence Level: 4 AUTHORS: PMID:2570694 NOTES:SAB
modifier: MODEL1310110001#

metaM hmgcoa x
is: SBO:0000247
boundary condition: false
is: HMDB01375
has only substance units: false
is: CHEBI:15467
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
type: Species
name: Hydroxymethylglutaryl-CoA
constant: false
initial amount: NaN
initial concentration: 1.0

metaM q10 m
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
boundary condition: false
is: SBO:0000247
initial amount: NaN
type: Species
name: ubiquinone-10
is: CHEBI:46245
is: HMDB01072

metaM ksi deg6 l
initial concentration: 1.0
is: SBO:0000247
constant: false
is: HMDB00143
is: CHEBI:12936
initial amount: NaN
type: Species
notes: FORMULA: C210H336N15O184S11 CHARGE: -11
boundary condition: false
name: keratan sulfate I, degradation product 6
has only substance units: false

metaR SFCYSc
is: SBO:0000176
fast: false
product: MODEL1310110001#
name: Formation of sulfocysteine
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID: 2621485 NOTES:non-enzymatic reaction. Sulfocysteine is excreted in the urine.One proton added for elemental balancing.
kinetic law: MODEL1310110001#
is described by: ECO:0000134
type: Reaction
reversible: true

metaR SUBERCROT
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of suberyl carnitine
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_270b95bc_0146_48bc_8d39_6a09be986bfe
constant: false
initial concentration: NaN
is encoded by: hsa:10846
initial amount: NaN
is: Q9Y233
type: Species
is: SBO:0000252
has only substance units: false
name: PDE10A
boundary condition: true

metaR FAOXC2242046m
is described by: ECO:0000000
modifier: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (34.1) or (35.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.74 Confidence Level: 4 AUTHORS: NOTES:_1 round beta ox peroxisomal (very long chain FA) c22:4,n-6 -> c20:4, n-6 - final '6' in abbreviation indicates omega6 FA 4 step FAO lumped for 2 rounds also includes EC 1.1.1.35, 1.1.1.211, 1.3.3.6, 4.2.1.17, 4.2.1.74 NJ
reversible: false
fast: false
is version of: http://identifiers.org/ec-code/1.3.99.3
product: MODEL1310110001#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.8.1

metaR EX gtp LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: GTP exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_30524c69_b9ed_41c5_a3d3_42e4b03240c1
type: Species
is encoded by: hsa:34
initial amount: NaN
initial concentration: NaN
constant: false
is: P11310
boundary condition: true
name: ACADM
is: SBO:0000252
has only substance units: false

metaM c51crn e
initial concentration: 1.0
type: Species
is: HMDB02366
notes: FORMULA: C12H21NO4 CHARGE: 0
boundary condition: false
is: SBO:0000247
name: tiglyl carnitine
constant: false
initial amount: NaN
has only substance units: false

metaM h c
is: SBO:0000247
is: CHEBI:24636
notes: FORMULA: H CHARGE: 1 INCHI: "
boundary condition: false
initial amount: NaN
is: http://identifiers.org/pubchem.compound/3380
type: Species
is: C00080
name: proton
has only substance units: false
constant: false
initial concentration: 1.0

metaR SMPD4
is described by: ECO:0000000
reactant: MODEL1310110001#
type: Reaction
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:12069827,PMID:9972865 NOTES:reaction details not determined - elucidated from PMID: 9972865, 12069827 NJ
name: sphingomyelinase
reversible: false
fast: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_c428b902_dcbe_4d24_b615_5146d850e5b7
name: ATP5H
initial amount: NaN
constant: false
has only substance units: false
type: Species
is: SBO:0000252
is encoded by: hsa:10476
boundary condition: true
initial concentration: NaN
is: A0PJH2

http://identifiers.org/biomodels.db/MODEL1310110001#_0e933fb5_959d_40f5_bf09_637caa5cc865
is encoded by: hsa:515
type: Species
constant: false
boundary condition: true
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: ATP5H:ATP5L:NSF:ATP5F1:ATP5G3:ATP5I:ATP5J:ATP5J2
is: SBO:0000297

metaR r0679
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.3.1.16
product: MODEL1310110001#
name: ATP:pantothenate 4-phosphotransferase Pantothenate and CoA biosynthesis EC:2.7.1.33
is described by: ECO:0000000
type: Reaction
modifier: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: CoA catabolism EC Number: 2.7.1.33 Confidence Level: 0 AUTHORS: PMID:10625688,PMID:13630913,PMID:15105273,PMID:15659606,PMID:16040613 NOTES:

metaR EX ttdca LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for tetradecanoate (n-C14:0)
type: Reaction

metaM arachdcrn m
constant: false
initial concentration: 1.0
type: Species
is: SBO:0000247
has only substance units: false
boundary condition: false
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
name: C20:4 carnitine
is: HMDB01322
is: CHEBI:57387
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_8bc5489a_0a4b_483c_92a1_1c227a5374b2
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:8703
name: B4GALT3
is: A8K5Z0
initial amount: NaN
initial concentration: NaN
has only substance units: false
constant: false

metaR RE1898C
reversible: true
fast: false
product: MODEL1310110001#
name: RE1898
is: SBO:0000176
type: Reaction
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110001#

metaM pectindchac e
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB03402
notes: FORMULA: C2559H3549O2539 CHARGE: -1
name: pectin-deoxycholic acid complex
type: Species
initial amount: NaN
has only substance units: false

metaR C81CRNe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octenoyl carnitine into the extra cellular space
type: Reaction

metaM ksi pre26 g
is: SBO:0000247
boundary condition: false
type: Species
has only substance units: false
name: keratan sulfate I biosynthesis, precursor 26
is: CHEBI:28067
constant: false
initial concentration: 1.0
notes: FORMULA: C199H318N14O166S8X CHARGE: -9
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_ad77e6fd_e074_419d_83ef_57f8bc70a438
name: RRM1
type: Species
constant: false
boundary condition: true
is: P23921
is encoded by: hsa:6240
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false

metaR NMNATr
is: SBO:0000176
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.7.1
fast: false
reactant: MODEL1310110001#
type: Reaction
is described by: ECO:0000269
name: nicotinamide-nucleotide adenylyltransferase
reversible: true
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (349565.1) or (23057.1) or (23057.2) SUBSYSTEM: NAD metabolism EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110001#

metaM HC01231 c
name: N-[(R)-pantothenoyl]-L-cysteinate
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
is: CHEBI:58480
boundary condition: false
has only substance units: false
constant: false
notes: FORMULA: C12H21N2O6S CHARGE: -1 INCHI: InChI=1S/C12H22N2O6S/c1-12(2,6-15)9(17)10(18)13-4-3-8(16)14-7(5-21)11(19)20/h7,9,15,17,21H,3-6H2,1-2H3,(H,13,18)(H,14,16)(H,19,20)/p-1/t7-,9-/m0/s1 EHMN_ABBREVIATION: C04079
type: Species

metaR HSD3A1r
modifier: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.225
kinetic law: MODEL1310110001#
type: Reaction
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 4 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
fast: false
reactant: MODEL1310110001#
is described by: ECO:0000269

http://identifiers.org/biomodels.db/MODEL1310110001#_1f4da533_a953_444d_893c_6393830eb3df
initial amount: NaN
boundary condition: true
type: Species
is: D3DX95
is: SBO:0000252
initial concentration: NaN
constant: false
has only substance units: false
is encoded by: hsa:1103
name: CHAT

http://identifiers.org/biomodels.db/MODEL1310110001#_996c4c5f_92d1_4c87_8f8b_f43d94246c1f
initial amount: NaN
is encoded by: hsa:2271
type: Species
is: P07954
is: SBO:0000252
name: FH
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR STRDNCCPT2
product: MODEL1310110001#
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.3.1.21
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
name: carnitine transferase
reactant: MODEL1310110001#
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_7d70dbf8_2d25_45e2_86cf_0c8d0e7f69eb
is encoded by: hsa:9415
name: FADS2
boundary condition: true
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is: O95864
constant: false
initial amount: NaN

metaM m2mpdol L c
name: (alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog
is: CHEBI:28049
initial concentration: 1.0
has only substance units: false
constant: false
boundary condition: false
notes: FORMULA: C1420H2328N20O320P20 CHARGE: -20
initial amount: NaN
type: Species
is: SBO:0000247

metaR HYXNt
type: Reaction
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:tv
product: MODEL1310110001#
reversible: true
is described by: ECO:0000269
reactant: MODEL1310110001#
name: Hypoxanthine transport
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000185

metaR EX atp LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: ATP exchange
type: Reaction

metaM dctp n
type: Species
initial amount: NaN
is: C00458
is: SBO:0000247
boundary condition: false
has only substance units: false
is: CHEBI:16311
notes: FORMULA: C9H12N3O13P3 CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC00367 EHMN_ABBREVIATION: C00458
name: dCTP
initial concentration: 1.0
is: HMDB00998
constant: false

metaR FAOXC201C181x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C20:1-->C18:1)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_831c4d0a_29f1_41bf_b7af_2059425222a8
boundary condition: true
is encoded by: hsa:1347
name: COX7A2
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: H0UI06

metaM tetde5coa x
is: HMDB13109
notes: FORMULA: C35H56N7O17P3S CHARGE: -4
name: 5-tetradecenoylcoa
has only substance units: false
boundary condition: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: SBO:0000247
type: Species

metaR S6T8g
type: Reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110001#
fast: false
reversible: false
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
modifier: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000176

metaR r1147
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
is: SBO:0000185
kinetic law: MODEL1310110001#
fast: false
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_eb4f0599_4e20_452f_9c17_2129a85baeee
name: CBR1
initial concentration: NaN
is: SBO:0000252
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:873
initial amount: NaN
is: P16152
constant: false

metaR TMDS
reversible: false
is version of: http://identifiers.org/ec-code/2.1.1.45
product: MODEL1310110001#
name: thymidylate synthase
notes: GENE_ASSOCIATION: (7298.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.1.1.45 Confidence Level: 4 AUTHORS: PMID:14967037,PMID:2243092 NOTES:
reactant: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
fast: false
is: SBO:0000176
is described by: ECO:0000269
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_a38b1f0b_1e1a_4210_94dd_e94088dfe1d3
constant: false
is encoded by: hsa:8776
is: Q13613
has only substance units: false
initial concentration: NaN
is: SBO:0000252
name: MTMR1
boundary condition: true
initial amount: NaN
type: Species

metaR DHORTS
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/2.1.3.2
is described by: ECO:0000269
fast: false
name: dihydroorotase
is: SBO:0000176
modifier: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: (790.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 3.5.2.3 Confidence Level: 4 AUTHORS: PMID:2565865,PMID:8619816 NOTES:
kinetic law: MODEL1310110001#

metaM glyc R c
is: CHEBI:16659
has only substance units: false
notes: FORMULA: C3H5O4 CHARGE: -1 INCHI: InChI=1S/C3H6O4/c4-1-2(5)3(6)7/h2,4-5H,1H2,(H,6,7)/p-1/t2-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00235
type: Species
constant: false
is: SBO:0000247
name: D-glycerate
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00139

http://identifiers.org/biomodels.db/MODEL1310110001#_bdf5bca5_1e1f_4864_baf5_9848f2747c18
is: P13196
constant: false
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:211
name: ALAS1
initial amount: NaN
boundary condition: true

metaR EX 5adtststerones LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 5alpha-Dihydrotestosterone sulfate exchange
type: Reaction

metaR C8CRNe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of octanoyl carnitine into the extra cellular space
type: Reaction

metaR FAOXTC102C101m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation trans(C10:2-->C10:1)m
type: Reaction

metaM ksi deg37 l
type: Species
has only substance units: false
is: CHEBI:57455
is: SBO:0000247
constant: false
notes: FORMULA: C62H104N4O46 CHARGE: 0
initial amount: NaN
is: HMDB01354
boundary condition: false
initial concentration: 1.0
name: keratan sulfate I, degradation product 37

http://identifiers.org/biomodels.db/MODEL1310110001#_ff9ba108_525d_4341_be92_087ab3207a99
has only substance units: false
is encoded by: hsa:8818
is: SBO:0000297
is encoded by: hsa:54344
initial amount: NaN
has part: Q9P2X0
constant: false
name: DPM3:DPM1:DPM2
initial concentration: NaN
type: Species
boundary condition: true

metaR ACt2m
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:10198029,PMID:15755952 NOTES:NCD
fast: false
type: Reaction
product: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
name: acetate mitochondrial transport via proton symport

metaR r1148
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
product: MODEL1310110001#
name: Active transport

metaR Rtotaltl
product: MODEL1310110001#
kinetic law: MODEL1310110001#
name: fatty acid intracellular transport
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism for transport - carnitine transporters not found, unknown mechanism intracellularly, however there must be a mechanism for FA transport NJ
fast: false
is: SBO:0000185
reversible: true
reactant: MODEL1310110001#
is described by: ECO:0000000

metaR EX malttr LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Maltotriose exchange
type: Reaction

metaR BHBt
is described by: ECO:0000000
name: (R)-3-Hydroxybutanoate transport via H+ symport
product: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:1408469,PMID:16380372 NOTES:IT, TDV
type: Reaction

metaM chito2pdol U c
initial amount: NaN
is: CHEBI:12427
constant: false
has only substance units: false
boundary condition: false
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human uterine homolog
type: Species
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C1185H1940N20O170P20 CHARGE: -20

http://identifiers.org/biomodels.db/MODEL1310110001#_9727205b_744e_4a6f_8779_8a346f9fc5d9
has only substance units: false
is: SBO:0000297
has part: Q86TM7
boundary condition: true
type: Species
initial amount: NaN
has part: O94777
constant: false
is encoded by: hsa:8818
is encoded by: hsa:54344
is encoded by: hsa:8813
has part: O60762
initial concentration: NaN
name: DPM3:DPM1:DPM2

metaR DPHMBDCm
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000
name: 3-Decaprenyl-4-hydroxy-5-methoxybenzoate decarboxylation
kinetic law: MODEL1310110001#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11051212,PMID:7380842 NOTES:enzyme has not been identified yet IT
is: SBO:0000176

metaM hs deg3 l
is: CHEBI:16126
constant: false
initial amount: NaN
initial concentration: 1.0
name: heparan sulfate, degradation product 3
notes: FORMULA: C81H117N5O97S10 CHARGE: -12
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false

metaM sgalside hs g
initial amount: NaN
boundary condition: false
name: sulfatide galactocerebroside
is: HMDB00061
has only substance units: false
constant: false
initial concentration: 1.0
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: CHEBI:58343
type: Species
is: SBO:0000247

metaR AICARte
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: Transport of 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-)
is: SBO:0000185
reversible: true
reactant: MODEL1310110001#
type: Reaction
fast: false
is described by: ECO:0000134

metaR EX ac LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Acetate exchange
type: Reaction

metaR GLCGLUT2
reversible: true
type: Reaction
is described by: ECO:0000134
name: Transport of glucose into the portal blood
modifier: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (6514.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 71-74 NOTES:GLUT-2 can also move to the apical surface and aid in glucose import into the cell under fully fed state (PMID: 17786952)
product: MODEL1310110001#
is: SBO:0000185
kinetic law: MODEL1310110001#

metaM tetpent6coa c
constant: false
is: SBO:0000247
name: tetracosapentaenoyl coenzyme A, n-6
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
initial amount: NaN
is: C16172
type: Species
has only substance units: false

metaR GLCNACASE4ly
notes: GENE_ASSOCIATION: (4669.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.2.1.50 Confidence Level: 4 AUTHORS: PMID:1783617,PMID:8776591,PMID:8993162 NOTES:NCD
is described by: ECO:0000000
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
reversible: false
name: alpha-N-acetylglucosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.50
reactant: MODEL1310110001#
type: Reaction
fast: false
product: MODEL1310110001#

metaM lnlc e
boundary condition: false
is: SBO:0000247
name: linoleate
has only substance units: false
type: Species
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C18H31O2 CHARGE: -1 INCHI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p-1/b7-6-,10-9-
is: HMDB00673
is: CHEBI:30245

http://identifiers.org/biomodels.db/MODEL1310110001#_5f433a27_b775_4604_9d7d_30ea1ac0c9e1
is: P34059
has only substance units: false
initial amount: NaN
constant: false
boundary condition: true
type: Species
initial concentration: NaN
name: GALNS
is encoded by: hsa:2588
is: SBO:0000252

metaM stcrn m
initial amount: NaN
boundary condition: false
name: stearoylcarnitine
has only substance units: false
is: SBO:0000247
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
type: Species
is: HMDB00848
initial concentration: 1.0
constant: false

metaR C10OHc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-OHdecanoylcarnitinec
type: Reaction

metaM 3bcrn e
initial amount: NaN
initial concentration: 1.0
constant: false
boundary condition: false
is: C14143
notes: FORMULA: C11H21NO5 CHARGE: 0
is: SBO:0000247
is: HMDB04047
has only substance units: false
type: Species
name: 3-hydroxy butyryl carnitine

metaR C161CPT12
is version of: http://identifiers.org/ec-code/2.3.1.21
kinetic law: MODEL1310110001#
name: carnitine O-palmitoyltransferase
is: SBO:0000176
is described by: ECO:0000269
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1375.1) or (1375.2) or (1374.1) or (1375.4) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
reversible: false
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_c725141e_0bfc_4865_b0e7_ff01e09f5d2e
boundary condition: true
is encoded by: hsa:3291
initial concentration: NaN
initial amount: NaN
constant: false
is: P80365
is: SBO:0000252
name: HSD11B2
has only substance units: false
type: Species

metaM apoC c
is: HMDB11111
initial amount: NaN
type: Species
has only substance units: false
notes: FORMULA: XH CHARGE: 0
is: SBO:0000247
name: Apocarboxlase (no lys residue)
is: CHEBI:33190
initial concentration: 1.0
boundary condition: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_e7bd84a9_129b_42b5_b3e1_e0793e21af69
type: Species
is: Q9HCC0
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:64087
constant: false
has only substance units: false
boundary condition: true
initial amount: NaN
name: MCCC2

metaR r2471
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
fast: false
is: SBO:0000185
name: Major Facilitator(MFS) TCDB:2.A.18.8.1
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:12748860 NOTES:
is described by: ECO:0000000
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110001#_82d52380_8074_43b6_8688_f9f835939acc
is encoded by: hsa:2181
boundary condition: true
constant: false
initial amount: NaN
has only substance units: false
type: Species
name: ACSL3
initial concentration: NaN
is: O95573
is: SBO:0000252

metaM ksi pre33 g
initial amount: NaN
name: keratan sulfate I biosynthesis, precursor 33
constant: false
notes: FORMULA: C233H372N16O197S10X CHARGE: -11
is: C00130
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB00175
is: CHEBI:58053
type: Species
has only substance units: false

metaR 4MOPte
reactant: MODEL1310110001#
name: Transport of 4-methyl-2-oxopentanoate
product: MODEL1310110001#
is described by: ECO:0000134
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: AUTHORS: NOTES:
reversible: true
kinetic law: MODEL1310110001#
is: SBO:0000185
type: Reaction
fast: false

metaR DCSPTN1t
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reversible: true
product: MODEL1310110001#
name: fatty acid transport via diffusion
type: Reaction
fast: false
reactant: MODEL1310110001#
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110001#_03f6bef8_231e_4669_a1d0_48690e77f846
initial concentration: NaN
name: MTR
is: Q99707
is encoded by: hsa:4548
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
boundary condition: true
has only substance units: false

metaR HIVCRNe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy-isovaleryl carnitine into extra cellular space
type: Reaction

metaM fn2m2masn g
boundary condition: false
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C56H93N4O39X CHARGE: 0 INCHI: InChI=1S/C60H100N6O42/c1-14-32(77)42(87)45(90)57(96-14)94-13-26-48(40(85)28(62-15(2)72)52(97-26)66-27(76)6-19(61)53(92)93)104-56-31(65-18(5)75)41(86)47(24(11-71)102-56)105-58-46(91)49(106-60-51(44(89)36(81)23(10-70)101-60)108-55-30(64-17(4)74)39(84)34(79)21(8-68)99-55)37(82)25(103-58)12-95-59-50(43(88)35(80)22(9-69)100-59)107-54-29(63-16(3)73)38(83)33(78)20(7-67)98-54/h14,19-26,28-52,54-60,67-71,77-91H,6-13,61H2,1-5H3,(H,62,72)(H,63,73)(H,64,74)(H,65,75)(H,66,76)(H,92,93)/t14-,19-,20+,21+,22+,23+,24+,25+,26+,28+,29+,30+,31+,32+,33+,34+,35+,36+,37+,38+,39+,40+,41+,42+,43-,44-,45-,46-,47+,48+,49-,50-,51-,52+,54-,55-,56-,57+,58-,59-,60+/m0/s1
has only substance units: false
initial concentration: 1.0
is: CHEBI:32984

metaR 4HBZFm
is: SBO:0000176
type: Reaction
is described by: ECO:0000000
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Ubiquinone synthesis EC Number: Confidence Level: 2 AUTHORS: PMID:11583838,PMID:12232327 NOTES:IT reaction involved in formation of 4-hydroxybenzoate from tyrosine.
reversible: false
name: 4-hydroxybenzoate formation
kinetic law: MODEL1310110001#
fast: false
product: MODEL1310110001#

metaM guln r
name: L-gulonate
is: CHEBI:13115
type: Species
notes: FORMULA: C6H11O7 CHARGE: -1 INCHI: InChI=1S/C6H12O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h2-5,7-11H,1H2,(H,12,13)/p-1/t2-,3+,4-,5-/m0/s1 EHMN_ABBREVIATION: C00800
boundary condition: false
constant: false
is: HMDB03290
initial amount: NaN
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

metaR FAOXC9C7m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C9-->C7)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_b8303c6e_d65b_449e_9eca_c1f518540454
has only substance units: false
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
is: Q15181
constant: false
boundary condition: true
is encoded by: hsa:5464
name: PPA1
type: Species

metaR ACt2r
is described by: ECO:0000000
name: acetate reversible transport via proton symport
fast: false
reactant: MODEL1310110001#
is: SBO:0000185
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:9651205 NOTES:NCD
kinetic law: MODEL1310110001#
product: MODEL1310110001#

metaM Ser Gly Ala X Gly l
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
name: protein-linked serine residue (glycosaminoglycan attachment site)
type: Species
initial amount: NaN
notes: FORMULA: XH CHARGE: 0
is: CHEBI:36005
constant: false
is: HMDB02183
has only substance units: false

metaR MANt4
is described by: ECO:0000269
modifier: MODEL1310110001#
reversible: true
product: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (200010.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:15607332 NOTES:NCD
reactant: MODEL1310110001#
is: SBO:0000185
fast: false
kinetic law: MODEL1310110001#
name: D-mannose transport via sodium cotransport

metaM 5dpmev x
initial amount: NaN
name: (R)-5-Diphosphomevalonate
is: SBO:0000247
is: CHEBI:15899
initial concentration: 1.0
type: Species
notes: FORMULA: C6H10O10P2 CHARGE: -4 INCHI: InChI=1S/C6H14O10P2/c1-6(9,4-5(7)8)2-3-15-18(13,14)16-17(10,11)12/h9H,2-4H2,1H3,(H,7,8)(H,13,14)(H2,10,11,12)/t6-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00685 EHMN_ABBREVIATION: C01143
boundary condition: false
has only substance units: false
constant: false
is: HMDB01090

metaM q10 c
name: ubiquinone-10
constant: false
type: Species
is: HMDB01072
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ HEPATONET_1.0_ABBREVIATION: HC00329 EHMN_ABBREVIATION: C11378
is: SBO:0000247
has only substance units: false
is: CHEBI:46245
initial amount: NaN

metaM c10dc x
constant: false
notes: FORMULA: C17H30NO6 CHARGE: -1
type: Species
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB00651
has only substance units: false
initial amount: NaN
name: sebacoyl carnitine

metaM spmd c
type: Species
boundary condition: false
is: HMDB01257
initial concentration: 1.0
constant: false
notes: FORMULA: C7H22N3 CHARGE: 3 HEPATONET_1.0_ABBREVIATION: HC00269 EHMN_ABBREVIATION: C00315
name: Spermidine
is: CHEBI:57834
is: C00315
initial amount: NaN
has only substance units: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_4045134d_1ebc_469b_9391_49ca37eea468
type: Species
boundary condition: true
is: SBO:0000252
initial amount: NaN
has only substance units: false
is encoded by: hsa:125061
initial concentration: NaN
name: AFMID
constant: false
is: Q63HM1

http://identifiers.org/biomodels.db/MODEL1310110001#_0c56d58f_b06c_494d_a035_3d7177e98f52
initial amount: NaN
has only substance units: false
is encoded by: hsa:10195
initial concentration: NaN
constant: false
is: SBO:0000252
boundary condition: true
name: ALG3
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_e918dd78_12e2_4af5_a72e_f4ef63fa191c
is: Q5JPH6
has only substance units: false
initial concentration: NaN
constant: false
type: Species
name: EARS2
is encoded by: hsa:124454
initial amount: NaN
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_a89da130_b95c_4f8e_a700_a16264277106
name: SUOX
is encoded by: hsa:6821
has only substance units: false
type: Species
boundary condition: true
constant: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
is: P51687

metaR 3AIB Dtm
kinetic law: MODEL1310110001#
reversible: true
type: Reaction
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: no transporter could be identified, so diffusion is assumed. NOTES:
product: MODEL1310110001#
name: transport of 3aib_D into mitochondria

metaR FAOXC163Gm
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C16:3)gm
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_9065c499_d80f_4f33_bf34_b066aaa3f30a
is encoded by: hsa:AA278423
constant: false
type: Species
initial concentration: NaN
initial amount: NaN
has only substance units: false
name: _AA278423_1_c
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_a50447c8_2b32_44af_9c7e_3046c8cfe23f
is: SBO:0000252
type: Species
is encoded by: hsa:BE966236
boundary condition: true
name: _BE966236_1_m
has only substance units: false
initial concentration: NaN
initial amount: NaN
constant: false

metaR S6T13g
product: MODEL1310110001#
type: Reaction
is: SBO:0000176
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (4166.1) or (10164.1) or (23563.2) or (23563.1) or (9435.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
is described by: ECO:0000000
reversible: false
fast: false
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#

metaR r1143
reactant: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
kinetic law: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:
reversible: false
product: MODEL1310110001#
fast: false

metaM thymd m
initial concentration: 1.0
initial amount: NaN
is: CHEBI:17748
is: C00214
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
is: SBO:0000247
constant: false
has only substance units: false
boundary condition: false
name: Thymidine
type: Species
is: HMDB00273

http://identifiers.org/biomodels.db/MODEL1310110001#_f7f70beb_924e_4e3d_bc01_8abf491eaeeb
initial amount: NaN
initial concentration: NaN
constant: false
is: Q9BYZ2
is encoded by: hsa:92483
name: LDHAL6B
boundary condition: true
has only substance units: false
type: Species
is: SBO:0000252

metaR STRDNCCPT1
is: SBO:0000176
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
is version of: http://identifiers.org/ec-code/2.3.1.21
modifier: MODEL1310110001#
is described by: ECO:0000000
reversible: false
name: carnitine O-palmitoyltransferase
fast: false
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
kinetic law: MODEL1310110001#

metaM ksii core2 deg3 l
boundary condition: false
type: Species
constant: false
initial concentration: 1.0
notes: FORMULA: C58H94N5O46S2X CHARGE: -2
initial amount: NaN
has only substance units: false
name: keratan sulfate II (core 2-linked), degradation product 3
is: CHEBI:12936
is: HMDB00143
is: SBO:0000247

metaM 13dampp c
name: trimethylenediaminium
is: CHEBI:57484
initial concentration: 1.0
constant: false
type: Species
notes: FORMULA: C3H12N2 CHARGE: 2 INCHI: InChI=1S/C3H10N2/c4-2-1-3-5/h1-5H2/p+2 EHMN_ABBREVIATION: C00986
is: HMDB00002
is: SBO:0000247
has only substance units: false
initial amount: NaN
boundary condition: false

metaR DPPS
reversible: false
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Miscellaneous EC Number: Confidence Level: 2 AUTHORS: PMID:16262699 NOTES:by analogy to other dimethyl transferase rxns. See PMID: 10586494, human interemidate (from C15 ->C50) not explicitly determined yet, however it is known to occur since this pathway is essential in Q10 synthesis. For human metabolism: may be associated w/ GeneID: 23590 TPRT - recheck lit in future IT and NJ
is: SBO:0000176
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000134
reactant: MODEL1310110001#
name: decaprenyl synthase

metaR DURAD
reversible: true
is version of: http://identifiers.org/ec-code/1.3.1.2
reactant: MODEL1310110001#
type: Reaction
name: dihydrouracil dehydrogenase (NADP)
product: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1806.1) SUBSYSTEM: Pyrimidine catabolism EC Number: 1.3.1.2 Confidence Level: 4 AUTHORS: PMID:1512248,PMID:8221682 NOTES:_01-26-05 IT based on Lu et al., JBC,1992,24,17102-17109
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
is described by: ECO:0000269

metaR BILIRUBtr
product: MODEL1310110001#
type: Reaction
name: lipid, flip-flop intracellular transport
is described by: ECO:0000000
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true

metaR r1144
is: SBO:0000185
kinetic law: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
type: Reaction
reversible: false
product: MODEL1310110001#
name: Major Facilitator(MFS) TCDB:2.A.18.6.3
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:10823827 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110001#

metaR Htg
product: MODEL1310110001#
name: proton diffusion (Golgi)
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110001#
fast: false
reversible: true
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: NOTES:
is: SBO:0000185

metaR ORNt3m
is: SBO:0000185
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NCD
product: MODEL1310110001#
reactant: MODEL1310110001#
reversible: true
is described by: ECO:0000269
fast: false
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
name: ornithine mitochondrial transport via proton antiport
type: Reaction

metaM cs e deg7 l
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7
constant: false
is: CHEBI:15936
notes: FORMULA: C23H35O27S2 CHARGE: -3

metaM q10 e
type: Species
name: ubiquinone-10
is: HMDB01072
is: SBO:0000247
notes: FORMULA: C59H90O4 CHARGE: 0 INCHI: InChI=1S/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:46245
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_5e062f4c_e292_43d4_a950_62b654f8e01f
has only substance units: false
is: SBO:0000252
boundary condition: true
is encoded by: hsa:6508
constant: false
initial concentration: NaN
name: SLC4A3
type: Species
initial amount: NaN

metaR F6Tg
is: SBO:0000176
notes: GENE_ASSOCIATION: (2530.4) or (2530.1) or (2530.3) or (2530.2) or (2530.5) SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.68 Confidence Level: 0 AUTHORS: PMID:14514715 NOTES:NCD
is version of: http://identifiers.org/ec-code/2.4.1.68
name: glycoprotein 6-alpha-L-fucosyltransferase
kinetic law: MODEL1310110001#
type: Reaction
fast: false
is described by: ECO:0000000
product: MODEL1310110001#
reactant: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#

metaR FAOXC161C161OHm
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: production of 3-hydroxyhexadecenoylcoA
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_a4ac02ad_769d_4c89_826c_aa035f219de1
type: Species
boundary condition: true
constant: false
name: SULT1A3
has only substance units: false
is encoded by: hsa:6818
initial concentration: NaN
initial amount: NaN
is: SBO:0000252

metaR 3SPYRSPm
name: 3-sulfinopyruvate hydrolase (spotaneous reaction), mitochondrial
is described by: ECO:0000000
is: SBO:0000176
fast: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
reversible: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:3346220 NOTES:MM

http://identifiers.org/biomodels.db/MODEL1310110001#_33a5a4cd_7c8b_4afc_9110_5f3c14259ce5
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
is encoded by: hsa:55753
constant: false
initial amount: NaN
name: OGDHL
is: Q9ULD0
has only substance units: false

metaM CE1925 e
notes: FORMULA: C16H21O4 CHARGE: -1 INCHI: InChI=1/C16H22O4/c1-9-10(2)15-12(11(3)14(9)19)5-7-16(4,20-15)8-6-13(17)18/h19H,5-8H2,1-4H3,(H,17,18)/p-1 EHMN_ABBREVIATION: CE1925
type: Species
constant: false
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
is: CHEBI:57923
initial amount: NaN
name: 3'-carboxy-alpha-chromanol
boundary condition: false

metaM sgalside hs c
initial concentration: 1.0
is: HMDB03406
initial amount: NaN
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: CHEBI:16523
boundary condition: false
name: sulfatide galactocerebroside
has only substance units: false
constant: false
is: SBO:0000247
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_2ee6f70e_e7fa_449b_bfad_11df83ad9323
has only substance units: false
initial concentration: NaN
name: SLC35D1
initial amount: NaN
boundary condition: true
constant: false
is: Q9NTN3
is: SBO:0000252
type: Species
is encoded by: hsa:23169

metaR AHEXASEly
reversible: false
reactant: MODEL1310110001#
modifier: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (3073.1) or (3074.1) or (3073.1 and 3074.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724 NOTES:NCD
kinetic law: MODEL1310110001#
name: beta-N-acetylhexosaminidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.52
is described by: ECO:0000000
is: SBO:0000176

metaR HDCACBP
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaM cit c
is: C00158
boundary condition: false
has only substance units: false
is: SBO:0000247
is: CHEBI:16947
initial amount: NaN
type: Species
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00153 EHMN_ABBREVIATION: C00158
is: HMDB00094
name: Citrate
initial concentration: 1.0
constant: false

metaM 3hmp m
is: SBO:0000247
initial concentration: 1.0
boundary condition: false
type: Species
constant: false
has only substance units: false
initial amount: NaN
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-3(2-5)4(6)7/h3,5H,2H2,1H3,(H,6,7)/p-1 HEPATONET_1.0_ABBREVIATION: HC00705 EHMN_ABBREVIATION: C01188
is: CHEBI:11805
name: 3-hydroxy-2-methylpropanoate
is: HMDB00023

metaR NDP8ex
reversible: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.6.1.6
modifier: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (124583.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.6.1.6 Confidence Level: 4 AUTHORS: PMID:12234496,PMID:12600208 NOTES:
name: nucleoside-diphosphatase (UTP), extracellular
kinetic law: MODEL1310110001#
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
product: MODEL1310110001#

metaR FAOXC226C227m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:7)m
type: Reaction

metaM arachd x
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15- HEPATONET_1.0_ABBREVIATION: HC00202 EHMN_ABBREVIATION: C00219
is: CHEBI:32395
type: Species
name: arachidonate
is: SBO:0000247
initial amount: NaN
constant: false
is: HMDB01043
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaM CE4872 m
is: HMDB00127
constant: false
is: SBO:0000247
initial amount: NaN
name: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al
has only substance units: false
initial concentration: 1.0
is: CHEBI:15748
type: Species
boundary condition: false
notes: FORMULA: C27H46O4 CHARGE: 0 INCHI: InChI=1/C27H46O4/c1-16(15-28)6-5-7-17(2)20-8-9-21-25-22(14-24(31)27(20,21)4)26(3)11-10-19(29)12-18(26)13-23(25)30/h15-25,29-31H,5-14H2,1-4H3/t16u,17-,18-,19+,20-,21-,22-,23+,24-,25-,26?,27-/m1/s1 EHMN_ABBREVIATION: CE4872

metaM hpdca e
is: SBO:0000247
constant: false
boundary condition: false
name: margarate
has only substance units: false
notes: FORMULA: C17H33O2 CHARGE: -1 INCHI: InChI=1S/C17H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-16H2,1H3,(H,18,19)/p-1
is: CHEBI:32366
initial concentration: 1.0
type: Species
initial amount: NaN
is: HMDB02259

metaM so4 m
is: HMDB01448
is: CHEBI:16189
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
has only substance units: false
is: SBO:0000247
name: sulfate
initial amount: NaN
initial concentration: 1.0
type: Species
constant: false

metaR PROD2m
notes: GENE_ASSOCIATION: (5625.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.99.8 Confidence Level: 2 AUTHORS: PMID:10192398 NOTES:JLR SAB m
is version of: http://identifiers.org/ec-code/1.5.99.8
name: Proline dehydrogenase (m)
type: Reaction
modifier: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: false
reactant: MODEL1310110001#
fast: false
is described by: ECO:0000254

metaR ADK1m
is version of: http://identifiers.org/ec-code/2.7.4.3
kinetic law: MODEL1310110001#
is: SBO:0000176
fast: false
modifier: MODEL1310110001#
is described by: ECO:0000269
reversible: true
type: Reaction
product: MODEL1310110001#
reactant: MODEL1310110001#
name: adenylate kinase, mitochondrial
notes: GENE_ASSOCIATION: (205.3) or (205.1) or (204.1) or (204.3) or (204.2) or (205.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.3 Confidence Level: 4 AUTHORS: PMID:11485571,PMID:195572,PMID:8843353,PMID:9434148 NOTES:NCD

metaM prostge2 e
is: HMDB01220
name: prostaglandin E2(1-)
has only substance units: false
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
is: SBO:0000247
boundary condition: false
constant: false
initial amount: NaN
type: Species
is: CHEBI:606564
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_69b6e6a9_fb86_49db_ba50_832f4e483aee
initial amount: NaN
type: Species
is encoded by: hsa:50484
has only substance units: false
constant: false
boundary condition: true
is: Q7LG56
initial concentration: NaN
name: RRM2B
is: SBO:0000252

metaR PYK
notes: GENE_ASSOCIATION: (5315.2) or (5313.2) or (5315.3) or (5313.1) or (113452.1) or (5315.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000134
type: Reaction
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000176
fast: false
kinetic law: MODEL1310110001#
name: pyruvate kinase
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.1.40
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110001#_9433b124_87b8_4240_923e_e6934d273b94
has only substance units: false
initial amount: NaN
name: _AA532636_1_m
type: Species
is: SBO:0000252
boundary condition: true
initial concentration: NaN
constant: false
is encoded by: hsa:AA532636

metaR PRO Dtde
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 1 AUTHORS: added during gap-filling. Diffusion into the blood is assumed. NOTES:added during gap-filling. Diffusion into the blood is assumed.
product: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000185
kinetic law: MODEL1310110001#
type: Reaction
name: D-proline transport, extracellular
fast: false
reversible: true
is described by: ECO:0000134

http://identifiers.org/biomodels.db/MODEL1310110001#_2a1d1263_1313_4181_a65e_9fa25ab0d5bc
name: COX2
boundary condition: true
type: Species
is encoded by: hsa:4513
constant: false
has only substance units: false
is: SBO:0000252
is: Q7GXZ8
initial concentration: NaN
initial amount: NaN

metaM ins c
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
type: Species
constant: false
is: C00294
initial amount: NaN
is: CHEBI:17596
has only substance units: false
name: Inosine
is: HMDB00195
initial concentration: 1.0
boundary condition: false
is: SBO:0000247

metaR HISCAT1
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: Transport of L-Histidine by y+ transporter
type: Reaction

metaM ksii core4 e
initial amount: NaN
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
boundary condition: false
type: Species
name: keratan sulfate II (core 4-linked)
is: HMDB00211
is: SBO:0000247
has only substance units: false
constant: false
is: CHEBI:17268
initial concentration: 1.0

metaR NDPK5
type: Reaction
is: SBO:0000176
modifier: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.2) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
fast: false
reactant: MODEL1310110001#
is described by: ECO:0000269
name: Nucleoside-diphosphate kinase (ATP:dGDP)
kinetic law: MODEL1310110001#

metaR H2Otp
name: H2O transport, peroxisomal
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reversible: true
fast: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185
reactant: MODEL1310110001#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_7e8f4352_e8b9_4f15_bce2_7dfd5fc5d9a7
is: E9KL44
name: HADHA
constant: false
is: SBO:0000252
initial amount: NaN
is encoded by: hsa:3030
has only substance units: false
type: Species
initial concentration: NaN
boundary condition: true

metaM HC01405 m
notes: FORMULA: C29H46N7O18P3S CHARGE: -4 INCHI: InChI=1S/C29H50N7O18P3S/c1-4-5-6-7-17(37)12-20(39)58-11-10-31-19(38)8-9-32-27(42)24(41)29(2,3)14-51-57(48,49)54-56(46,47)50-13-18-23(53-55(43,44)45)22(40)28(52-18)36-16-35-21-25(30)33-15-34-26(21)36/h15-18,22-24,28,37,40-41H,4-14H2,1-3H3,(H,31,38)(H,32,42)(H,46,47)(H,48,49)(H2,30,33,34)(H2,43,44,45)/t17-,18+,22+,23+,24-,28+/m0/s1 EHMN_ABBREVIATION: C05266
has only substance units: false
constant: false
initial amount: NaN
is: CHEBI:28632
name: (S)-Hydroxyoctanoyl-CoA
boundary condition: false
initial concentration: 1.0
type: Species
is: SBO:0000247

metaR r1589
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110001#
type: Reaction
fast: false
reactant: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
product: MODEL1310110001#
is: SBO:0000185
reversible: true

metaR EX pydx5p LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of pyridoxal 5-phosphate(2-)
type: Reaction

metaR PTDCACRNt
modifier: MODEL1310110001#
name: pentadecanoate transport into the mitochondria
is: SBO:0000185
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:NJ
type: Reaction
product: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reversible: false

metaR LNSTLSr
is described by: ECO:0000134
type: Reaction
notes: GENE_ASSOCIATION: (4047.1) SUBSYSTEM: Cholesterol metabolism EC Number: 5.4.99.7 Confidence Level: 2 AUTHORS: PMID:17925399,PMID:17925400,PMID:18830876,PMID:18830877 NOTES:NCD ER version - NJ
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/5.4.99.7
kinetic law: MODEL1310110001#
name: lanosterol synthase
reactant: MODEL1310110001#

metaR PE HSter
type: Reaction
product: MODEL1310110001#
name: phosphatidylethanolamine scramblase
is: SBO:0000185
fast: false
reversible: true
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:10856717,PMID:15311932 NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_c6cd8ce6_fc8a_478c_bdd3_421ea8d71fd0
initial concentration: NaN
type: Species
has only substance units: false
name: ALDH3A2
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:224
is: P51648

metaM leuktrE4 c
type: Species
initial amount: NaN
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: SBO:0000247
boundary condition: false
is: CHEBI:57462
has only substance units: false
initial concentration: 1.0
is: HMDB02200
name: leukotriene E4(1-)
constant: false

metaR GALtly
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
fast: false
name: galactose efflux from lysosome
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
type: Reaction
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_6061a965_e75b_4fa0_bf4b_3a6c4f6895b0
is encoded by: hsa:6581
is: SBO:0000252
constant: false
is: Q5SYN6
type: Species
has only substance units: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: SLC22A3

metaM adpac x
type: Species
initial concentration: 1.0
name: adipic acid
is: SBO:0000247
initial amount: NaN
constant: false
boundary condition: false
notes: FORMULA: C6H8O4 CHARGE: -2
is: HMDB00448
has only substance units: false

metaR NDPK7
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
reactant: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
fast: false
product: MODEL1310110001#
name: nucleoside-diphosphate kinase (ATP:dCDP)
modifier: MODEL1310110001#
is described by: ECO:0000269
is: SBO:0000176

metaR r0671
notes: GENE_ASSOCIATION: (2717.1) or (6173.1) SUBSYSTEM: CoA synthesis EC Number: 6.3.2.5 Confidence Level: 0 AUTHORS: PMID:11923312,PMID:12906824,PMID:15893380 NOTES:
type: Reaction
is: SBO:0000176
is version of: http://identifiers.org/ec-code/3.2.1.22
reactant: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: (R)-4-Phosphopantothenate:L-cysteine ligase EC:6.3.2.5
fast: false
is described by: ECO:0000000

metaR PHACCOAGLNAC
notes: GENE_ASSOCIATION: SUBSYSTEM: Phenylalanine metabolism EC Number: 2.3.1.14 Confidence Level: 2 AUTHORS: NOTES:SAB
is described by: ECO:0000000
type: Reaction
product: MODEL1310110001#
reactant: MODEL1310110001#
name: Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
fast: false
kinetic law: MODEL1310110001#
reversible: false
is: SBO:0000176

metaR r1150
is: SBO:0000185
name: Facilitated diffusion
fast: false
reactant: MODEL1310110001#
reversible: false
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 0 AUTHORS: PMID:8691743 NOTES:
product: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#

metaM sebcoa x
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/16019966
notes: FORMULA: C31H47N7O19P3S CHARGE: -5
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000247
type: Species
name: sebacoylcoa
boundary condition: false

metaM amp x
notes: FORMULA: C10H12N5O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00030 EHMN_ABBREVIATION: C00020
has only substance units: false
initial amount: NaN
constant: false
name: AMP
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:456215
is: HMDB00045
boundary condition: false
type: Species
is: C00020

metaR NDPK6
reactant: MODEL1310110001#
is described by: ECO:0000269
kinetic law: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
name: Nucleoside-diphosphate kinase (ATP:dUDP)
is: SBO:0000176
modifier: MODEL1310110001#
fast: false

metaM doldp L r
boundary condition: false
type: Species
name: Dolichol diphosphate, human liver homolog
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C1080H1758O70P20 CHARGE: -30 INCHI: InChI=1S/C25H46O7P2/c1-21(2)11-7-12-22(3)13-8-14-23(4)15-9-16-24(5)17-10-18-25(6)19-20-31-34(29,30)32-33(26,27)28/h11,13,15,17,25H,7-10,12,14,16,18-20H2,1-6H3,(H,29,30)(H2,26,27,28)/b22-13+,23-15+,24-17-
constant: false
is: CHEBI:15750
has only substance units: false

metaR HDCEAtr
kinetic law: MODEL1310110001#
is described by: ECO:0000000
reversible: true
is: SBO:0000185
product: MODEL1310110001#
name: fatty acid transport via diffusion
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
fast: false
reactant: MODEL1310110001#
type: Reaction

metaR r1588
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
type: Reaction
product: MODEL1310110001#
is: SBO:0000185
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#

metaM slfcys e
is: HMDB00731
notes: FORMULA: C3H8NO5S2 CHARGE: -1
is: C05824
name: S-Sulfo-L-cysteine
initial amount: NaN
constant: false
has only substance units: false
type: Species
initial concentration: 1.0
is: SBO:0000247
boundary condition: false

metaM 2hb e
is: HMDB00008
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
boundary condition: false
has only substance units: false
type: Species
name: 2-Hydroxybutyrate
constant: false
is: CHEBI:1148
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247

metaM ksi deg20 l
name: keratan sulfate I, degradation product 20
notes: FORMULA: C138H223N9O119S6 CHARGE: -6
is: SBO:0000247
initial amount: NaN
is: CHEBI:12936
initial concentration: 1.0
has only substance units: false
boundary condition: false
constant: false
is: HMDB00143
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_0aa92b27_42da_429d_a485_0d933906acd3
type: Species
initial concentration: NaN
has only substance units: false
boundary condition: true
name: PC
constant: false
initial amount: NaN
is encoded by: hsa:5091
is: SBO:0000252
is: P11498

metaR EX 4hphac LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: 4-Hydroxyphenylacetate exchange
type: Reaction

metaR FAOXC205C185m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:5)m
type: Reaction

metaR P5CR
product: MODEL1310110001#
type: Reaction
name: pyrroline-5-carboxylate reductase
kinetic law: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.2 Confidence Level: 4 AUTHORS: PMID: 11458019, Sareen S. Gropper, jack L. Smith, James L. Groff (2009) Wadaworth cengage learning, Advanced nutrition and human metabolism, 5th edition, page 194-196 NOTES:
reactant: MODEL1310110001#
reversible: false
is described by: ECO:0000134
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_b34308b5_8eaf_46c3_9107_7e76df760fb3
boundary condition: true
initial amount: NaN
name: NT5E
is: SBO:0000252
is: P21589
initial concentration: NaN
type: Species
has only substance units: false
is encoded by: hsa:4907
constant: false

metaM ins e
initial amount: NaN
is: CHEBI:17596
is: HMDB00195
notes: FORMULA: C10H12N4O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00255 EHMN_ABBREVIATION: C00294
is: SBO:0000247
has only substance units: false
boundary condition: false
type: Species
constant: false
is: C00294
name: Inosine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_ddf4da8e_26a9_413e_99cb_3f46075e4a2d
is: SBO:0000252
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
type: Species
name: _BE966236_1_c
is encoded by: hsa:BE966236
boundary condition: true

metaR NDPK8
is described by: ECO:0000269
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.6
name: Nucleoside-diphosphate kinase (ATP:dADP)
modifier: MODEL1310110001#
is: SBO:0000176
type: Reaction
fast: false
product: MODEL1310110001#

metaR r1587
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110001#
reversible: true
type: Reaction
fast: false
kinetic law: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

http://identifiers.org/biomodels.db/MODEL1310110001#_e2a3daa5_37f0_4b84_86ff_4ef9ee1189a2
boundary condition: true
name: ACP1
initial concentration: NaN
is encoded by: hsa:52
has only substance units: false
type: Species
is: SBO:0000252
is: B5MCC7
constant: false
initial amount: NaN

metaM 3hexdcoa m
initial amount: NaN
has only substance units: false
boundary condition: false
is: HMDB03932
type: Species
is: SBO:0000247
name: 3-hydroxyhexadecanoylcoa
is: C05258
notes: FORMULA: C37H62N7O18P3S CHARGE: -4
constant: false
initial concentration: 1.0

metaR r0909
fast: false
is: SBO:0000185
reactant: MODEL1310110001#
name: Transport reaction
kinetic law: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
product: MODEL1310110001#
reversible: true
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_aebafcfd_ea3a_4184_a72e_5b88d806475e
type: Species
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
name: B3GALNT1
has only substance units: false
constant: false
is encoded by: hsa:8706
is: Q49AT3

metaR H2Otn
is: SBO:0000185
reactant: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
reversible: true
kinetic law: MODEL1310110001#
name: H2O transport, nuclear
fast: false
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110001#_64d10426_5a9e_41f4_8f03_0a353ea1464b
is encoded by: hsa:5210
initial amount: NaN
has only substance units: false
boundary condition: true
initial concentration: NaN
type: Species
constant: false
is: SBO:0000252
name: PFKFB4
is: Q16877

http://identifiers.org/biomodels.db/MODEL1310110001#_95b4a197_9417_4b6d_9b37_fc5b5a1aafe0
is encoded by: hsa:AA977580
type: Species
name: _AA977580_1_c
is: SBO:0000252
boundary condition: true
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN

metaR METt4
is described by: ECO:0000269
name: L-methionine transport in via sodium symport
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (81539.1) or (11254.1) or (54407.1) or (6584.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10747860,PMID:10891391,PMID:10930503,PMID:11325958 NOTES:SAB
reversible: false
product: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000185
type: Reaction
fast: false
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_bad0abec_baec_4fe3_a7fb_d2b722b0330f
is encoded by: hsa:79017
initial amount: NaN
is: B8ZZR8
constant: false
has only substance units: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252
name: GGCT
type: Species

metaR PI4P3K
product: MODEL1310110001#
reactant: MODEL1310110001#
name: phosphatidylinositol 4-phosphate 3-kinase
is described by: ECO:0000000
kinetic law: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/2.7.1.153
reversible: false
is version of: http://identifiers.org/ec-code/2.7.11.1
is: SBO:0000176
notes: GENE_ASSOCIATION: (5291.1 and 5295.3) or (5296.1 and 5290.1) or (5293.1 and 5296.1) or (5287.1) or (5286.1) or (5293.1 and 8503.1) or (5293.1 and 5295.3) or (5291.1 and 8503.1) or (5295.2 and 5290.1) or (5288.1) or (5291.1 and 5295.1) or (5296.1 and 5291.1) or (23533.1 and 5294.1) or (5293.1 and 5295.1) or (5295.2 and 5293.1) or (5290.1 and 8503.1) or (5290.1 and 5295.3) or (10870.1 and 5294.1) or (5295.2 and 5291.1) or (5290.1 and 5295.1) SUBSYSTEM: Inositol phosphate metabolism EC Number: 2.7.1.68 Confidence Level: 4 AUTHORS: PMID:7624799,PMID:7713498,PMID:8246984,PMID:9113989,PMID:9337861,PMID:9830063,PMID:9878262 NOTES:NCD Notice that contrary to some standards in texts, KEGG, etc, the Rtotal group accounts for the whole fatty acyl CoA (so the CHO only accounts for the core backbone), manner in which Rtotal was produced accounts for O and H balances. Formation of the Rtotal group (rxn flux)accounted for mass balance for CoA NJ changed EC from 2.7.1.149 (pail5p) to 2.7.1.68 (pail4p) - NCD
is version of: http://identifiers.org/ec-code/2.7.1.154

metaM ksii core4 g
initial concentration: 1.0
is: HMDB01644
type: Species
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
boundary condition: false
is: SBO:0000247
name: keratan sulfate II (core 4-linked)
is: CHEBI:17140
constant: false
has only substance units: false
initial amount: NaN

metaM phaccoa c
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C29H38N7O17P3S CHARGE: -4 INCHI: InChI=1S/C29H42N7O17P3S/c1-29(2,24(40)27(41)32-9-8-19(37)31-10-11-57-20(38)12-17-6-4-3-5-7-17)14-50-56(47,48)53-55(45,46)49-13-18-23(52-54(42,43)44)22(39)28(51-18)36-16-35-21-25(30)33-15-34-26(21)36/h3-7,15-16,18,22-24,28,39-40H,8-14H2,1-2H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44)/p-4/t18-,22-,23-,24+,28-/m1/s1
boundary condition: false
constant: false
type: Species
is: SBO:0000247
is: HMDB06503
has only substance units: false
is: CHEBI:57390
name: phenylacetyl-CoA(4-)

metaR NACHEX20ly
modifier: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (3073.1 and 3074.1) or (3074.1) or (3073.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.52 Confidence Level: 4 AUTHORS: PMID:10336991,PMID:11707436,PMID:12706724,PMID:8993162 NOTES:NCD
reversible: false
fast: false
name: beta-N-acetylhexosaminidase, lysosomal
product: MODEL1310110001#
is: SBO:0000176
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.52

metaR FACOAL150
fast: false
notes: GENE_ASSOCIATION: (22305.2) or (2182.1) or (2180.1) or (2181.2) or (2181.1) or (22305.1) SUBSYSTEM: Fatty acid oxidation EC Number: 6.2.1.3 Confidence Level: 4 AUTHORS: PMID:15292367 NOTES:AR
product: MODEL1310110001#
reactant: MODEL1310110001#
name: fatty-acid--CoA ligase
is version of: http://identifiers.org/ec-code/6.2.1.3
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
reversible: true
is: SBO:0000176
is described by: ECO:0000000
type: Reaction

metaM naglc2p L c
constant: false
is: CHEBI:18278
notes: FORMULA: C1160H1898N10O120P20 CHARGE: -20 INCHI: InChI=1S/C33H59NO12P2/c1-23(2)12-8-13-24(3)14-9-15-25(4)16-10-17-26(5)18-11-19-27(6)20-21-43-47(39,40)46-48(41,42)45-33-30(34-28(7)36)32(38)31(37)29(22-35)44-33/h12,14,16,18,27,29-33,35,37-38H,8-11,13,15,17,19-22H2,1-7H3,(H,34,36)(H,39,40)(H,41,42)/b24-14+,25-16+,26-18-/t27?,29-,30-,31-,32-,33-/m1/s1
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human liver homolog
initial concentration: 1.0
is: SBO:0000247
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN

metaR ORPT
type: Reaction
is: SBO:0000176
reversible: true
notes: GENE_ASSOCIATION: (7372.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 2.4.2.10 Confidence Level: 4 AUTHORS: PMID:3279416,PMID:6574608,PMID:6893554,PMID:9042911 NOTES:
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.2.10
name: orotate phosphoribosyltransferase
is described by: ECO:0000269
fast: false
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#

metaM arachdcrn c
is: HMDB01322
is: CHEBI:57387
initial concentration: 1.0
initial amount: NaN
boundary condition: false
is: SBO:0000247
notes: FORMULA: C27H45NO4 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC12236
has only substance units: false
constant: false
type: Species
name: C20:4 carnitine

metaM so4 l
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
type: Species
boundary condition: false
constant: false
is: HMDB01448
has only substance units: false
initial concentration: 1.0
is: SBO:0000247
name: sulfate
initial amount: NaN
is: CHEBI:16189

metaM leuktrE4 e
initial amount: NaN
is: SBO:0000247
name: leukotriene E4(1-)
type: Species
boundary condition: false
notes: FORMULA: C23H36NO5S CHARGE: -1 INCHI: InChI=1S/C23H37NO5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-21(30-18-19(24)23(28)29)20(25)15-14-17-22(26)27/h6-7,9-13,16,19-21,25H,2-5,8,14-15,17-18,24H2,1H3,(H,26,27)(H,28,29)/p-1/b7-6-,10-9-,12-11+,16-13+/t19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C05952
is: CHEBI:57462
initial concentration: 1.0
is: HMDB02200
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_a55a371b_b841_475e_a684_4e07666532d6
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is: P02730
is encoded by: hsa:6521
boundary condition: true
type: Species
name: SLC4A1
has only substance units: false
constant: false

metaR r2063
is: SBO:0000185
fast: false
is described by: ECO:0000000
reversible: false
modifier: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.15
type: Reaction
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_965c2774_ada3_46b8_8a46_f2987c2d0270
has only substance units: false
initial amount: NaN
is: SBO:0000252
is: P31939
type: Species
name: ATIC
is encoded by: hsa:471
initial concentration: NaN
constant: false
boundary condition: true

metaM thcholstoic m
is: SBO:0000247
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
boundary condition: false
initial concentration: 1.0
is: HMDB03873
initial amount: NaN
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
type: Species
has only substance units: false
is: CHEBI:18402
constant: false

metaR NDPK9
type: Reaction
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
fast: false
name: nucleoside-diphosphate kinase (ATP:IDP)
is described by: ECO:0000269
is: SBO:0000176
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: NOTES:NCD
reactant: MODEL1310110001#

metaR r1586
reactant: MODEL1310110001#
product: MODEL1310110001#
fast: false
is described by: ECO:0000000
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
type: Reaction

metaR r1771
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
type: Reaction
product: MODEL1310110001#
is: SBO:0000185
reactant: MODEL1310110001#
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reversible: false
fast: false
name: Y+LAT2 Utilized transport
modifier: MODEL1310110001#

metaR O2St
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:12939409 NOTES:
product: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
name: superoxide anion transport via diffusion (extracellular)

metaR r0908
fast: false
is: SBO:0000185
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:3988731,PMID:6706970,PMID:7050120 NOTES:
name: Postulated transport reaction
reversible: true
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_84466805_6aad_4734_aad6_36f4982b4e8f
initial amount: NaN
type: Species
has only substance units: false
initial concentration: NaN
is encoded by: hsa:5298
boundary condition: true
is: Q9UBF8
is: SBO:0000252
constant: false
name: PI4KB

metaM glyc3p x
is: C00093
boundary condition: false
name: Glycerol 3-phosphate
is: SBO:0000247
is: HMDB00126
type: Species
notes: FORMULA: C3H7O6P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00095 EHMN_ABBREVIATION: C00093
has only substance units: false
initial amount: NaN
initial concentration: 1.0
constant: false
is: CHEBI:57597

metaM HC01162 c
is: CHEBI:58376
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
type: Species
notes: FORMULA: C20H29N4O17P CHARGE: -2 INCHI: InChI=1S/C20H31N4O17P/c21-10-1-2-24(19(35)22-10)17-15(32)14(31)9(39-17)6-38-42(36,37)41-20(18(33)34)3-7(27)12(23-11(29)5-26)16(40-20)13(30)8(28)4-25/h1-2,7-9,12-17,25-28,30-32H,3-6H2,(H,23,29)(H,33,34)(H,36,37)(H2,21,22,35)/p-2/t7-,8+,9+,12+,13+,14+,15+,16+,17+,20+/m0/s1 EHMN_ABBREVIATION: C03691
initial concentration: 1.0
boundary condition: false
name: (2R,4S,5R,6R)-2-[({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphinato)oxy]-4-hydroxy-5-(2-hydroxyacetamido)-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate

metaR H2Otm
name: H2O transport, mitochondrial
kinetic law: MODEL1310110001#
fast: false
product: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (343.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:15749715 NOTES:IF
type: Reaction
is described by: ECO:0000269
reversible: true
is: SBO:0000185
reactant: MODEL1310110001#

metaR SERDGLNexR
type: Reaction
is: SBO:0000185
fast: false
name: D-Serine/Glutamine reversible exchange
reversible: true
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000304

metaM hmgcoa m
is: SBO:0000247
is: CHEBI:15467
has only substance units: false
is: HMDB01375
notes: FORMULA: C27H39N7O20P3S CHARGE: -5 INCHI: InChI=1S/C27H44N7O20P3S/c1-26(2,21(40)24(41)30-5-4-15(35)29-6-7-58-17(38)9-27(3,42)8-16(36)37)11-51-57(48,49)54-56(46,47)50-10-14-20(53-55(43,44)45)19(39)25(52-14)34-13-33-18-22(28)31-12-32-23(18)34/h12-14,19-21,25,39-40,42H,4-11H2,1-3H3,(H,29,35)(H,30,41)(H,36,37)(H,46,47)(H,48,49)(H2,28,31,32)(H2,43,44,45)/t14-,19-,20-,21+,25-,27+/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00302 EHMN_ABBREVIATION: C00356
initial concentration: 1.0
type: Species
boundary condition: false
name: Hydroxymethylglutaryl-CoA
constant: false
initial amount: NaN

metaM slfcys c
is: SBO:0000247
notes: FORMULA: C3H8NO5S2 CHARGE: -1
name: S-Sulfo-L-cysteine
is: HMDB00731
is: C05824
has only substance units: false
initial concentration: 1.0
initial amount: NaN
type: Species
constant: false
boundary condition: false

metaM 2hb c
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C4H7O3 CHARGE: -1 INCHI: InChI=1S/C4H8O3/c1-2-3(5)4(6)7/h3,5H,2H2,1H3,(H,6,7) HEPATONET_1.0_ABBREVIATION: HC01669 EHMN_ABBREVIATION: C05984
has only substance units: false
boundary condition: false
is: HMDB00008
name: 2-Hydroxybutyrate
type: Species
is: CHEBI:1148
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_7b2c0a00_a204_4627_b6f3_c93d74828993
name: MGAT1
has only substance units: false
initial concentration: NaN
type: Species
is: P26572
boundary condition: true
initial amount: NaN
is encoded by: hsa:4245
is: SBO:0000252
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_699d7745_8ad3_495c_86df_ae79a0c9bc08
type: Species
name: GPI
is: P06744
initial concentration: NaN
has only substance units: false
constant: false
is: SBO:0000252
boundary condition: true
initial amount: NaN
is encoded by: hsa:2821

metaM c6crn c
is: SBO:0000247
constant: false
type: Species
has only substance units: false
initial concentration: 1.0
is: HMDB00705
initial amount: NaN
notes: FORMULA: C13H25NO4 CHARGE: 0
boundary condition: false
name: hexanoyl carnitine

metaR BMTer L
reversible: false
modifier: MODEL1310110001#
is described by: ECO:0000000
name: B mannosyltransferase, endoplasmic reticulum
is: SBO:0000176
product: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (9488.1) SUBSYSTEM: Phosphatidylinositol phosphate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:8861954 NOTES:NCD
kinetic law: MODEL1310110001#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_31b3346a_f3d0_4ded_88eb_d499a9c95d84
is encoded by: hsa:6391
is: SBO:0000297
has part: Q99643
boundary condition: true
type: Species
is encoded by: hsa:6392
has part: O14521
constant: false
initial concentration: NaN
has part: P21912
is encoded by: hsa:6389
has part: P31040
is encoded by: hsa:6390
name: SDHA:SDHB:SDHC:SDHD
initial amount: NaN
has only substance units: false

metaR DHAAt1r
notes: GENE_ASSOCIATION: (6515.1) or (6513.1) or (6517.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10421229,PMID:12750891,PMID:15705056,PMID:2656669,PMID:3170580,PMID:8504756,PMID:9230074 NOTES:NCD
modifier: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000185
reversible: true
kinetic law: MODEL1310110001#
fast: false
product: MODEL1310110001#
is described by: ECO:0000269
name: dehydroascorbate transport (uniport)

http://identifiers.org/biomodels.db/MODEL1310110001#_c2af62e1_254f_4dc5_837a_5b6df349ef19
name: RDH11
initial concentration: NaN
is: B4DDW0
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
is encoded by: hsa:51109
boundary condition: true

metaM arach c
is: HMDB02212
type: Species
name: arachidate
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
is: CHEBI:32360
initial concentration: 1.0
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
constant: false

metaM thm c
type: Species
notes: FORMULA: C12H17N4OS CHARGE: 1
boundary condition: false
has only substance units: false
constant: false
is: HMDB00235
initial concentration: 1.0
is: CHEBI:0
name: Thiamin
is: SBO:0000247
is: C00378
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_47288a09_1962_4864_b7ca_acd3b447046c
name: _AI345944_1_m
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:AI345944
constant: false
boundary condition: true
initial amount: NaN

metaR EX Lcystin LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Cystine exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_458e28d1_a859_434c_a4bd_75233f02138e
boundary condition: true
type: Species
name: ATP5G2
constant: false
is encoded by: hsa:517
initial concentration: NaN
is: Q06055
initial amount: NaN
has only substance units: false
is: SBO:0000252

metaM arab L c
is: HMDB00646
constant: false
boundary condition: false
has only substance units: false
is: CHEBI:30849
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C5H10O5 CHARGE: 0
name: L-arabinose
type: Species

metaR NDPK1
type: Reaction
is described by: ECO:0000134
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
product: MODEL1310110001#
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
name: nucleoside-diphosphate kinase (ATP:GDP)
reactant: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: (4832.1) or (10201.1) or (4831.1 and 4830.1) or (29922.2) or (4831.1 and 4830.2) or (29922.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_c941585d_ec65_4571_91aa_b40ae1da7709
name: ETFA:ETFB
has part: P13804
constant: false
boundary condition: true
is encoded by: hsa:2109
is encoded by: hsa:2108
has only substance units: false
type: Species
is: SBO:0000297
initial amount: NaN
initial concentration: NaN

metaR r2506
fast: false
type: Reaction
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
name: Utilized transport
reversible: true
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110001#
product: MODEL1310110001#

metaR RE3381E
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: true
modifier: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
is: SBO:0000176
name: RE3381
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (9365.1) SUBSYSTEM: Miscellaneous EC Number: 3.2.1.31 Confidence Level: 0 AUTHORS: PMID:10191290,PMID:10690708,PMID:11087858,PMID:11818531 NOTES:
fast: false

metaM 3aib D m
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB02299
notes: FORMULA: C4H9NO2 CHARGE: 0 INCHI: InChI=1/C4H9NO2/c1-3(2-5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00715
constant: false
is: C03265
is: SBO:0000247
has only substance units: false
name: D-3-Amino-isobutanoate
type: Species

metaM prgnlones c
is: SBO:0000247
is: HMDB00774
constant: false
initial amount: NaN
name: pregnenolone sulfate
is: CHEBI:35420
initial concentration: 1.0
notes: FORMULA: C21H31O5S CHARGE: -1 INCHI: InChI=1S/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: CE4764
boundary condition: false
type: Species
has only substance units: false

metaM c101crn e
is: HMDB13205
constant: false
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
name: decenoyl carnitine
is: SBO:0000247
notes: FORMULA: C17H31NO4 CHARGE: 0
boundary condition: false

metaM 7dhf e
is: HMDB06559
boundary condition: false
is: SBO:0000247
has only substance units: false
name: heptaglutamyl folate (DHF)
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C49H55N13O24 CHARGE: -8 INCHI: InChI=1/C54H68N14O27/c55-24(5-12-31(69)70)39(83)52(49(92)93,40(84)25(56)6-13-32(71)72)53(41(85)26(57)7-14-33(73)74,42(86)27(58)8-15-34(75)76)54(43(87)28(59)9-16-35(77)78,50(94)95-48(91)30(61)11-18-37(81)82)68(47(90)29(60)10-17-36(79)80)46(89)21-1-3-22(4-2-21)63-19-23-20-64-44-38(65-23)45(88)67-51(62)66-44/h1-4,20,24-30,63H,5-19,55-61H2,(H,69,70)(H,71,72)(H,73,74)(H,75,76)(H,77,78)(H,79,80)(H,81,82)(H,92,93)(H3,62,64,66,67,88)/t24-,25-,26-,27-,28-,29-,30-,54?/m0/s1
type: Species

metaM 4hoxpacd c
is: SBO:0000247
type: Species
is: HMDB03767
is: CHEBI:15621
has only substance units: false
constant: false
initial amount: NaN
notes: FORMULA: C8H8O2 CHARGE: 0 INCHI: InChI=1S/C8H8O2/c9-6-5-7-1-3-8(10)4-2-7/h1-4,6,10H,5H2 EHMN_ABBREVIATION: C03765
boundary condition: false
initial concentration: 1.0
name: (4-hydroxyphenyl)acetaldehyde

metaR NDPK2
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
modifier: MODEL1310110001#
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
fast: false
product: MODEL1310110001#
type: Reaction
name: nucleoside-diphosphate kinase (ATP:UDP)
is described by: ECO:0000269
notes: GENE_ASSOCIATION: (4832.1) or (29922.1) or (4831.1 and 4830.1) or (10201.1) or (4831.1 and 4830.2) or (29922.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
is: SBO:0000176

metaM thymd c
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:17748
is: SBO:0000247
initial amount: NaN
is: HMDB00273
is: C00214
has only substance units: false
constant: false
name: Thymidine

metaM hspg l
name: heparan sulfate proteoglycan
initial concentration: 1.0
is: CHEBI:17899
type: Species
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
is: SBO:0000247
is: HMDB01993
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false

metaM 3ttetddcoa c
initial concentration: 1.0
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
name: 3-hydroxy trans5,8tetradecadienoyl coa
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB02014
initial amount: NaN
has only substance units: false
type: Species

metaR r2509
type: Reaction
is: SBO:0000185
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
name: Utilized transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
reversible: true
is described by: ECO:0000000

metaM thcholstoic r
boundary condition: false
constant: false
initial amount: NaN
is: HMDB03873
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: SBO:0000247
initial concentration: 1.0
has only substance units: false
is: CHEBI:18402
type: Species
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722

metaM pyr m
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
is: SBO:0000247
has only substance units: false
type: Species
boundary condition: false
initial concentration: 1.0
is: CHEBI:15361
is: HMDB00243
name: pyruvate
constant: false
is: http://identifiers.org/pubchem.compound/3324
is: C00022
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_1839a983_ecc6_4b59_a9c1_87eb2e515b52
type: Species
boundary condition: true
has only substance units: false
is encoded by: hsa:4758
is: Q99519
name: NEU1
initial amount: NaN
constant: false
is: SBO:0000252
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_90c5cda2_7941_405b_b424_6c9011e5e3ae
initial amount: NaN
initial concentration: NaN
name: SLC4A8
is encoded by: hsa:9498
boundary condition: true
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is: E7EML0

metaR DOLMANP Lter
is described by: ECO:0000000
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:12137737 NOTES:
type: Reaction
name: dolichol-phosphate mannose flippase (liver)
reversible: false
kinetic law: MODEL1310110001#
fast: false
is: SBO:0000185
product: MODEL1310110001#

metaM arach e
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h2-19H2,1H3,(H,21,22)/p-1 EHMN_ABBREVIATION: CE0102
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.0
is: HMDB02212
initial amount: NaN
is: CHEBI:32360
type: Species
is: SBO:0000247
name: arachidate

http://identifiers.org/biomodels.db/MODEL1310110001#_65640734_19d8_4f73_8c45_0f4f5adef1eb
type: Species
constant: false
is: SBO:0000252
is encoded by: hsa:56894
initial amount: NaN
has only substance units: false
name: AGPAT3
boundary condition: true
initial concentration: NaN
is: Q9NRZ7

metaR ACNAM9PL
reactant: MODEL1310110001#
fast: false
is: SBO:0000176
product: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/2.5.1.56
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
kinetic law: MODEL1310110001#
reversible: false
is described by: ECO:0000269
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (54187.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.5.1.56 Confidence Level: 4 AUTHORS: PMID:10749855 NOTES:EC-2.5.1.56 NCD

http://identifiers.org/biomodels.db/MODEL1310110001#_caa5b3c6_4579_4c43_9641_40763863d410
is: Q92523
has only substance units: false
initial amount: NaN
name: CPT1B
is encoded by: hsa:1375
boundary condition: true
constant: false
initial concentration: NaN
type: Species
is: SBO:0000252

metaM ksi deg26 l
type: Species
constant: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C110H179N7O93S4 CHARGE: -4
is: HMDB00061
initial amount: NaN
has only substance units: false
name: keratan sulfate I, degradation product 26
is: CHEBI:58343
initial concentration: 1.0

metaR 2HBt2
reversible: true
name: 2-hydroxybutyrate cotransport with proton
kinetic law: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000269
fast: false
modifier: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (9123.1) or (9194.1) or (6566.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
reactant: MODEL1310110001#

metaR NDPK3
product: MODEL1310110001#
name: nucleoside-diphosphate kinase (ATP:CDP)
is: SBO:0000176
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.6
reversible: true
reactant: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
is described by: ECO:0000269
type: Reaction
notes: GENE_ASSOCIATION: (4832.1) or (29922.2) or (4831.1 and 4830.1) or (29922.1) or (10201.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:

http://identifiers.org/biomodels.db/MODEL1310110001#_3419c23b_6d08_4821_84bb_cfdc6d356031
name: ALDH5A1
boundary condition: true
is: Q546H9
is: SBO:0000252
initial amount: NaN
type: Species
initial concentration: NaN
has only substance units: false
constant: false
is encoded by: hsa:7915

metaM ksii core4 l
constant: false
is: SBO:0000247
boundary condition: false
is: CHEBI:17140
has only substance units: false
notes: FORMULA: C89H142N7O72S3X CHARGE: -4
initial concentration: 1.0
is: HMDB01644
initial amount: NaN
type: Species
name: keratan sulfate II (core 4-linked)

metaM 4mzym int1 r
notes: FORMULA: C29H46O3 CHARGE: 0 INCHI: InChI=1/C29H46O3/c1-18(2)8-7-9-19(3)21-11-12-22-20-10-13-24-28(5,23(20)14-16-27(21,22)4)17-15-25(30)29(24,6)26(31)32/h8,19,21-22,24-25,30H,7,9-17H2,1-6H3,(H,31,32)/t19-,21?,22?,24?,25-,27+,28+,29-/m0/s1
is: SBO:0000247
initial amount: NaN
constant: false
type: Species
boundary condition: false
has only substance units: false
name: 4-Methylzymosterol intermediate 1
is: HMDB06927
initial concentration: 1.0

metaR DAG HSter
reversible: false
is described by: ECO:0000000
is: SBO:0000185
name: diacylglycerol ER export
fast: false
product: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:
type: Reaction
kinetic law: MODEL1310110001#

metaR EX tre LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Trehalose exchange
type: Reaction

metaR r2508
product: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 0 AUTHORS: PMID:17466261 NOTES:
is: SBO:0000185
name: Utilized transport
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110001#
type: Reaction
fast: false

metaR OCDCAtr
name: fatty acid transport via diffusion
fast: false
type: Reaction
reversible: true
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
is described by: ECO:0000000
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#

metaR DMNONCOACRNCPT1
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:
is described by: ECO:0000000
reversible: true
fast: false
name: DMNONCOACRNCPT1
is: SBO:0000176
product: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#

metaM c101crn c
has only substance units: false
is: HMDB13205
constant: false
type: Species
initial concentration: 1.0
initial amount: NaN
name: decenoyl carnitine
notes: FORMULA: C17H31NO4 CHARGE: 0
boundary condition: false
is: SBO:0000247

metaM gncore2 g
initial concentration: 1.0
is: CHEBI:15876
has only substance units: false
constant: false
is: SBO:0000247
type: Species
boundary condition: false
initial amount: NaN
notes: FORMULA: C30H50N3O20X CHARGE: 0
name: GlcNAc-alpha-1,4-Core 2

metaM ksii core2 deg7 l
is: HMDB01354
initial amount: NaN
name: keratan sulfate II (core 2-linked), degradation product 7
type: Species
has only substance units: false
constant: false
boundary condition: false
is: CHEBI:57455
initial concentration: 1.0
notes: FORMULA: C44H73N4O30X CHARGE: 0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_5cfcfb94_1e66_4ba6_87f0_2c7d55b2f79a
is: O14561
name: NDUFAB1
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:4706
boundary condition: true
type: Species

metaM thymd e
has only substance units: false
name: Thymidine
type: Species
notes: FORMULA: C10H14N2O5 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00198 EHMN_ABBREVIATION: C00214
boundary condition: false
is: SBO:0000247
is: CHEBI:17748
initial amount: NaN
initial concentration: 1.0
is: C00214
is: HMDB00273
constant: false

metaR r1775
reversible: false
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
name: Y+LAT2 Utilized transport
modifier: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#

metaM sgalside hs l
notes: FORMULA: C24H45NO10SFULLRCO CHARGE: -1
is: HMDB00904
initial amount: NaN
constant: false
is: CHEBI:16349
boundary condition: false
type: Species
has only substance units: false
name: sulfatide galactocerebroside
is: SBO:0000247
initial concentration: 1.0

metaR NDPK4
modifier: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (4832.1) or (4831.1 and 4830.1) or (10201.1) or (29922.2) or (29922.1) or (4831.1 and 4830.2) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110001#
is described by: ECO:0000269
reversible: true
product: MODEL1310110001#
name: nucleoside-diphosphate kinase (ATP:dTDP)
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
is: SBO:0000176
reactant: MODEL1310110001#

metaM HC02179 c
type: Species
initial amount: NaN
is: SBO:0000247
is: CHEBI:34306
has only substance units: false
constant: false
initial concentration: 1.0
name: 20-hydroxy-arachidonate
boundary condition: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748

metaR ACALDt
reversible: true
reactant: MODEL1310110001#
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110001#
fast: false
is described by: ECO:0000000
product: MODEL1310110001#
name: acetaldehyde reversible transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:NCD

http://identifiers.org/biomodels.db/MODEL1310110001#_41bf3189_6dbb_430f_b560_1ad8ded2db5c
boundary condition: true
type: Species
is: SBO:0000252
name: SLC25A1
is encoded by: hsa:6576
initial concentration: NaN
is: D9HTE9
has only substance units: false
initial amount: NaN
constant: false

metaR CSND
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyrimidine catabolism EC Number: 3.5.4.1 Confidence Level: 2 AUTHORS: NOTES:JLR. Part of a famous suicide gene combination with 5-fluorocytosine
is: SBO:0000176
reversible: false
type: Reaction
kinetic law: MODEL1310110001#
name: Cytosine deaminase
is described by: ECO:0000000
fast: false
product: MODEL1310110001#
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_a14a453b_0af0_464f_aace_9c805527aff0
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
is encoded by: hsa:57665
name: RDH14
constant: false
is: Q9HBH5
initial concentration: NaN
initial amount: NaN

metaR SIAASE4ly
type: Reaction
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.6.4
reversible: false
is described by: ECO:0000000
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.4.16.5
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
name: sialidase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
kinetic law: MODEL1310110001#
product: MODEL1310110001#
fast: false

metaM 3mob e
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1
initial amount: NaN
name: 3-methyl-2-oxobutanoate
is: HMDB00019
is: CHEBI:11851
type: Species
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
constant: false
has only substance units: false

metaR r2359
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
is: SBO:0000185
type: Reaction
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
fast: false
reactant: MODEL1310110001#
name: Organic anion transporter 5 Utilized transport
reversible: true

metaM 3ttetddcoa m
constant: false
initial amount: NaN
is: HMDB02014
notes: FORMULA: C35H54N7O18P3S CHARGE: -4
type: Species
has only substance units: false
name: 3-hydroxy trans5,8tetradecadienoyl coa
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR GLYtm
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:7388024 NOTES:TDV Biochim Biophys Acta. 1980 Jun 6;598(3):588-94
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reversible: true
name: glycine passive transport to mitochondria
type: Reaction
fast: false
is described by: ECO:0000000
is: SBO:0000185

http://identifiers.org/biomodels.db/MODEL1310110001#_a0e2038d_8996_4683_8a52_880c37fcec2f
name: DPM3
initial amount: NaN
type: Species
boundary condition: true
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is: Q9P2X0
is encoded by: hsa:54344
constant: false

metaM so4 e
initial amount: NaN
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
constant: false
initial concentration: 1.0
name: sulfate
type: Species
is: SBO:0000247
is: CHEBI:16189
has only substance units: false
is: HMDB01448
boundary condition: false

metaR r1581
is: SBO:0000185
is described by: ECO:0000000
product: MODEL1310110001#
fast: false
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
reactant: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
kinetic law: MODEL1310110001#

metaM glyc c
is: C00116
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
name: Glycerol
type: Species
is: CHEBI:17754
is: HMDB00131
initial concentration: 1.0
has only substance units: false
constant: false
initial amount: NaN
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_aa7475c8_ea09_43a1_9970_0866054544f8
constant: false
type: Species
is encoded by: hsa:1962
is: Q9NY65
is: SBO:0000252
name: EHHADH
initial concentration: NaN
boundary condition: true
initial amount: NaN
has only substance units: false

metaR LNELDCt
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110001#
name: fatty acid transport via diffusion
kinetic law: MODEL1310110001#
fast: false
product: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:11788354,PMID:12864740 NOTES:NJ
type: Reaction

metaR EX c101crn
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for decenoyl carnitine
type: Reaction

metaR MG2er
type: Reaction
product: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is described by: ECO:0000000
reactant: MODEL1310110001#
fast: false
reversible: false

metaR r2358
is: SBO:0000185
product: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
type: Reaction
is described by: ECO:0000000

metaR RE3626M
reactant: MODEL1310110001#
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/1.3.3.6
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.3.6 Confidence Level: 0 AUTHORS: PMID:11356164,PMID:7775433 NOTES:
type: Reaction
modifier: MODEL1310110001#
name: RE3626
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reversible: false

http://identifiers.org/biomodels.db/MODEL1310110001#_ee21aa46_91bf_452b_89ac_5839b7362270
type: Species
name: _AL050025_1_c
initial concentration: NaN
has only substance units: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
constant: false
is encoded by: hsa:AL050025

metaR HISyLATtc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: Transport of L-Histidine by y+LAT1 or y+LAT2 transporters in small intestine and kidney
type: Reaction

metaR r1580
product: MODEL1310110001#
fast: false
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM arab L e
boundary condition: false
initial amount: NaN
notes: FORMULA: C5H10O5 CHARGE: 0
name: L-arabinose
type: Species
initial concentration: 1.0
is: CHEBI:30849
is: SBO:0000247
constant: false
has only substance units: false
is: HMDB00646

metaR r2357
fast: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
reversible: true
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110001#

metaR EX chsterol LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for cholesterol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_7ebede34_0f78_45b2_9741_bac761c974df
has only substance units: false
type: Species
is encoded by: hsa:1384
name: CRAT
initial amount: NaN
constant: false
boundary condition: true
initial concentration: NaN
is: SBO:0000252

metaM 3mob c
type: Species
has only substance units: false
boundary condition: false
initial amount: NaN
is: SBO:0000247
is: HMDB00019
is: CHEBI:11851
name: 3-methyl-2-oxobutanoate
constant: false
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial concentration: 1.0

metaM 2mp2coa m
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: CHEBI:27754
is: SBO:0000247
constant: false
boundary condition: false
type: Species
is: HMDB01011
notes: FORMULA: C25H36N7O17P3S CHARGE: -4 INCHI: InChI=1S/C25H40N7O17P3S/c1-13(2)24(37)53-8-7-27-15(33)5-6-28-22(36)19(35)25(3,4)10-46-52(43,44)49-51(41,42)45-9-14-18(48-50(38,39)40)17(34)23(47-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-12,14,17-19,23,34-35H,1,5-10H2,2-4H3,(H,27,33)(H,28,36)(H,41,42)(H,43,44)(H2,26,29,30)(H2,38,39,40)/t14-,17-,18-,19+,23-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01122 EHMN_ABBREVIATION: C03460
name: 2-Methylprop-2-enoyl-CoA

http://identifiers.org/biomodels.db/MODEL1310110001#_17317ba8_609f_4b14_a16e_e2e11786866e
is: SBO:0000252
is encoded by: hsa:9153
name: SLC28A2
initial concentration: NaN
boundary condition: true
is: O43868
constant: false
type: Species
has only substance units: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_17331713_b599_4e3c_9adc_edc59003924b
name: BCAT1
is encoded by: hsa:586
is: P54687
initial concentration: NaN
initial amount: NaN
has only substance units: false
is: SBO:0000252
type: Species
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_47dca7b9_0234_4577_9f26_f4fa81be5aa7
has only substance units: false
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:250
boundary condition: true
type: Species
name: ALPP
is: P05187
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_e4714442_ed1e_4a95_acb2_a296a5c1b191
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:4830
type: Species
constant: false
has only substance units: false
initial concentration: NaN
is: P15531
name: NME1
boundary condition: true

metaM so4 c
initial concentration: 1.0
initial amount: NaN
name: sulfate
constant: false
type: Species
is: CHEBI:16189
has only substance units: false
is: SBO:0000247
boundary condition: false
notes: FORMULA: O4S CHARGE: -2 INCHI: InChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2 HEPATONET_1.0_ABBREVIATION: HC00062 EHMN_ABBREVIATION: C00059
is: HMDB01448

metaM HC02179 e
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: CHEBI:34306
name: 20-hydroxy-arachidonate
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C20H31O3 CHARGE: -1 INCHI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)/b3-1-,6-4-,9-7-,12-10- EHMN_ABBREVIATION: C14748
has only substance units: false

metaR RE3079X
reversible: true
modifier: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
name: RE3079
type: Reaction
fast: false
is: SBO:0000176
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.2.1.3
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 0 AUTHORS: PMID:11356164 NOTES:IT - fixed proton

metaR EX dha LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone
type: Reaction

metaM glyc e
boundary condition: false
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
type: Species
is: CHEBI:17754
name: Glycerol
is: HMDB00131
initial concentration: 1.0
constant: false
initial amount: NaN
has only substance units: false
is: SBO:0000247
is: C00116

metaR DNDPt11m
name: dADP transport via dGDP antiport
is described by: ECO:0000269
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (60386.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:11226231 NOTES:IT
modifier: MODEL1310110001#
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_c49925ca_5691_4339_922a_291e287911b2
is encoded by: hsa:56894
constant: false
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
is: SBO:0000252
initial concentration: NaN
name: AGPAT3

http://identifiers.org/biomodels.db/MODEL1310110001#_3d1bc70d_0841_4152_9c1d_3667028aeef9
has only substance units: false
constant: false
initial concentration: NaN
name: _AI539321_1_c
is: SBO:0000252
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:AI539321

metaR r2356
is described by: ECO:0000000
kinetic law: MODEL1310110001#
type: Reaction
name: Organic anion transporter 5 Utilized transport
is: SBO:0000185
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
fast: false
product: MODEL1310110001#
reversible: true

metaM HC01408 m
initial amount: NaN
boundary condition: false
initial concentration: 1.0
name: 3-Oxohexanoyl-CoA
is: CHEBI:27648
type: Species
is: SBO:0000247
notes: FORMULA: C27H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C27H44N7O18P3S/c1-4-5-15(35)10-18(37)56-9-8-29-17(36)6-7-30-25(40)22(39)27(2,3)12-49-55(46,47)52-54(44,45)48-11-16-21(51-53(41,42)43)20(38)26(50-16)34-14-33-19-23(28)31-13-32-24(19)34/h13-14,16,20-22,26,38-39H,4-12H2,1-3H3,(H,29,36)(H,30,40)(H,44,45)(H,46,47)(H2,28,31,32)(H2,41,42,43)/t16-,20-,21-,22+,26-/m1/s1 EHMN_ABBREVIATION: C05269
constant: false
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_791f621c_1c57_463f_8477_d50c1daa4452
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
is encoded by: hsa:AA021081
type: Species
constant: false
name: _AA021081_1_r
boundary condition: true
has only substance units: false

metaR UDPG4E
is: SBO:0000176
notes: GENE_ASSOCIATION: (2582.1) or (2582.2) SUBSYSTEM: Galactose metabolism EC Number: 5.1.3.2 Confidence Level: 0 AUTHORS: PMID:11117433 NOTES:used yeast system to overexpress gene to determine mutant kinetic properties
name: UDPglucose 4-epimerase
product: MODEL1310110001#
is described by: ECO:0000134
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
is version of: http://identifiers.org/ec-code/5.1.3.2
fast: false
type: Reaction
modifier: MODEL1310110001#

metaR GUAPRT
product: MODEL1310110001#
is: SBO:0000176
name: guanine phosphoribosyltransferase
notes: GENE_ASSOCIATION: (3251.1) SUBSYSTEM: Nucleotide salvage pathway EC Number: 2.4.2.8 Confidence Level: 4 AUTHORS: PMID:3008106,PMID:6853490 NOTES:Guanine and 6-mercaptopurine can replace hypoxanthine EC added (2.4.2.7 makes the same reaction) IT
reversible: false
type: Reaction
reactant: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.2.8
is described by: ECO:0000269
kinetic law: MODEL1310110001#

metaR r2355
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
kinetic law: MODEL1310110001#
reversible: true
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185

metaR r1585
kinetic law: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reversible: true
type: Reaction
fast: false
reactant: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185

metaM arachd e
type: Species
initial concentration: 1.0
is: HMDB01043
initial amount: NaN
name: arachidonate
has only substance units: false
is: SBO:0000247
is: CHEBI:32395
boundary condition: false
constant: false
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-

http://identifiers.org/biomodels.db/MODEL1310110001#_345f7e7b_32ac_4ebd_9598_87337411f5e3
is encoded by: hsa:8869
constant: false
initial amount: NaN
initial concentration: NaN
type: Species
name: ST3GAL5
is: Q9UNP4
is: SBO:0000252
has only substance units: false
boundary condition: true

metaR r0781
is: SBO:0000176
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.35
reversible: true
is version of: http://identifiers.org/ec-code/4.2.1.17
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.14.13.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
modifier: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.2.1.107
type: Reaction
fast: false
kinetic law: MODEL1310110001#
name: Lanosterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) Biosynthesis of steroids EC:1.14.13.70

metaR NDPK6n
reactant: MODEL1310110001#
is: SBO:0000176
reversible: true
is version of: http://identifiers.org/ec-code/2.7.4.6
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dUDP), nuclear
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 4 AUTHORS: PMID:7050910 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.. Presence in the nucleus
fast: false
product: MODEL1310110001#
is described by: ECO:0000304

metaM pyr c
is: HMDB00243
type: Species
is: CHEBI:15361
boundary condition: false
initial amount: NaN
notes: FORMULA: C3H3O3 CHARGE: -1
is: C00022
constant: false
initial concentration: 1.0
is: SBO:0000247
name: pyruvate
is: http://identifiers.org/pubchem.compound/3324
has only substance units: false

metaR DESAT22 2p
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#
reactant: MODEL1310110001#
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid synthesis EC Number: 1.14.19.1 Confidence Level: 4 AUTHORS: NOTES:
name: fatty acyl-CoA desaturase (n-C22:5CoA -> n-C22:6CoA)
fast: false
is described by: ECO:0000000

metaR FAOXC10C8x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C10-->C8)x
type: Reaction

metaM hexdtrcoa m
type: Species
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
initial concentration: 1.0
is: SBO:0000247
constant: false
has only substance units: false
initial amount: NaN
is: HMDB02288
boundary condition: false
name: 7,10,13-hexadecatrienoylcoa

metaR 35CGMPtn
type: Reaction
reversible: true
kinetic law: MODEL1310110001#
is described by: ECO:0000000
name: 35cGMP nuclear transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 2 AUTHORS: NOTES:IT
fast: false
product: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000185

metaM thcholstoic x
initial concentration: 1.0
boundary condition: false
type: Species
initial amount: NaN
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
is: HMDB03873
constant: false
is: SBO:0000247
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
is: CHEBI:18402
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_a5799999_e0e6_40a0_a4fe_5bc4b2c8ad5e
has only substance units: false
is encoded by: hsa:58510
initial amount: NaN
name: PRODH2
is: SBO:0000252
is: Q9UF12
type: Species
initial concentration: NaN
boundary condition: true
constant: false

metaM ascb L e
is: SBO:0000247
type: Species
initial concentration: 1.0
name: L-ascorbate
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: HMDB00044
is: CHEBI:38290
boundary condition: false
initial amount: NaN
has only substance units: false
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_2c00a24c_03fe_4dd2_9d05_fc149bcdffdd
is: SBO:0000252
has only substance units: false
initial concentration: NaN
is: P35575
name: G6PC
constant: false
type: Species
boundary condition: true
is encoded by: hsa:2538
initial amount: NaN

metaR r2354
type: Reaction
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
product: MODEL1310110001#
is: SBO:0000185
reversible: true
fast: false
is described by: ECO:0000000
name: Organic anion transporter 5 Utilized transport

metaM abt e
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
name: L-arabinitol
is: CHEBI:18403
boundary condition: false
constant: false
is: SBO:0000247
is: HMDB01851
initial concentration: 1.0
type: Species
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_ba46fc18_6c0c_4eda_ad2c_ed4068153d29
name: PDE3B
initial amount: NaN
has only substance units: false
is: A7E2E5
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:5140
boundary condition: true

metaR EHGLAT2m
is: SBO:0000176
name: L-erythro-4-Hydroxyglutamate:2-oxoglutarate aminotransferase 2, mitochondrial
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (2806.1) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 2.6.1.21 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464 NOTES:NCD SAB oaa -> asp-L
product: MODEL1310110001#
is described by: ECO:0000304
is version of: http://identifiers.org/ec-code/2.6.1.1
fast: false
reversible: false

metaR TPI
is: SBO:0000176
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) SUBSYSTEM: Glycolysis/gluconeogenesis EC Number: 5.3.1.1 Confidence Level: 0 AUTHORS: PMID:18456264,PMID:18840520,PMID:2579079,PMID:999837 NOTES:SMP. 18840520 - expression data; 18456264 - protein purification; 2579079 - genetic, homology; 999837 - biochemical
type: Reaction
fast: false
name: triose-phosphate isomerase
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
product: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
is described by: ECO:0000134
is version of: http://identifiers.org/ec-code/5.3.1.1

http://identifiers.org/biomodels.db/MODEL1310110001#_313bb4a5_f7c5_4035_975e_2502f945895e
is: SBO:0000252
type: Species
is encoded by: hsa:2582
name: GALE
constant: false
initial concentration: NaN
is: Q14376
boundary condition: true
initial amount: NaN
has only substance units: false

metaR GLCtly
type: Reaction
name: glucose efflux from lysosome
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, lysosomal EC Number: Confidence Level: 2 AUTHORS: PMID:1751541,PMID:8993166 NOTES:NCD
kinetic law: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
reversible: false
fast: false
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_5244b736_3135_42cc_b4fc_efe480181451
has only substance units: false
boundary condition: true
name: LYZL1
initial concentration: NaN
is: Q6UWQ5
is encoded by: hsa:84569
initial amount: NaN
constant: false
is: SBO:0000252
type: Species

metaR r1584
fast: false
is described by: ECO:0000000
reactant: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
reversible: true
type: Reaction
product: MODEL1310110001#

metaR r0780
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
name: 4,4-dimethyl-5a-cholesta-8,24-dien-3b-ol:NADP+ D14-oxidoreductase Biosynthesis of steroids EC:1.3.1.70
reversible: true
notes: GENE_ASSOCIATION: (30.1) or (10449.1) or (3032.1) or (4645.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.70 Confidence Level: 0 AUTHORS: PMID:11969204,PMID:7946524 NOTES:
is described by: ECO:0000000
product: MODEL1310110001#
modifier: MODEL1310110001#
type: Reaction
fast: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.16

metaR C10DCCACT
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of sebacoyl carnitine into cytosol
type: Reaction

metaR NDPK6m
kinetic law: MODEL1310110001#
fast: false
is: SBO:0000176
reversible: true
type: Reaction
product: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000254
name: nucleoside-diphosphate kinase (ATP:dUDP), mitochondrial
notes: GENE_ASSOCIATION: (4833.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.6 Confidence Level: 2 AUTHORS: PMID:9099850 NOTES:Many nucleoside diphosphates (eight described) can act as acceptors. While many ribo- and deoxyribonucleoside triphosphates can act as donors, only ATP is chosen as a donor to minimize the number of total reactions.
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.4.6

http://identifiers.org/biomodels.db/MODEL1310110001#_bdfce298_7035_4e05_9969_21a0a2484bc0
is: SBO:0000252
boundary condition: true
type: Species
has only substance units: false
name: ATP10A
constant: false
initial amount: NaN
initial concentration: NaN
is encoded by: hsa:57194
is: O60312

metaM ksi pre19 g
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
name: keratan sulfate I biosynthesis, precursor 19
has only substance units: false
notes: FORMULA: C171H275N12O137S5X CHARGE: -6
initial amount: NaN
is: CHEBI:58053
type: Species
is: C00130
is: HMDB00175

metaR EX rib D LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ribose
type: Reaction

metaR THMP
type: Reaction
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine metabolism EC Number: Confidence Level: 1 AUTHORS: PMID:11997266,PMID:8522961 NOTES:EC 3.1.3.- NCD
reversible: false
kinetic law: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110001#
name: thiamin phosphatase
reactant: MODEL1310110001#

metaM hspg e
notes: FORMULA: C79H113N5O101S12X CHARGE: -13
name: heparan sulfate proteoglycan
type: Species
boundary condition: false
is: HMDB02259
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:32366
has only substance units: false
is: SBO:0000247

metaR r2353
is: SBO:0000185
kinetic law: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
name: Organic anion transporter 5 Utilized transport
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_2b9b860d_9c2f_4f1b_b707_aeb99ebb1457
is encoded by: hsa:AI348006
constant: false
boundary condition: true
type: Species
has only substance units: false
is: SBO:0000252
initial amount: NaN
initial concentration: NaN
name: _AI348006_1_c

metaR r0783
name: lanosterol D24-reductase Biosynthesis of steroids EC:1.3.1.72
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.35
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/4.2.1.17
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.72 Confidence Level: 0 AUTHORS: PMID:7946524 NOTES:
type: Reaction
modifier: MODEL1310110001#
fast: false
is: SBO:0000176

metaM prostge2 c
boundary condition: false
constant: false
is: SBO:0000247
type: Species
notes: FORMULA: C20H31O5 CHARGE: -1 INCHI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/p-1/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1 EHMN_ABBREVIATION: C00584
name: prostaglandin E2(1-)
has only substance units: false
initial amount: NaN
is: HMDB01220
initial concentration: 1.0
is: CHEBI:606564

metaR r1583
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
fast: false
is described by: ECO:0000000
product: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
is: SBO:0000185

metaM pyr e
is: CHEBI:15361
initial amount: NaN
is: HMDB00243
notes: FORMULA: C3H3O3 CHARGE: -1 INCHI: InChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
name: pyruvate
has only substance units: false
type: Species
initial concentration: 1.0
constant: false
is: SBO:0000247
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_a2adad73_42e3_4c5a_ac62_2c35bc3b67ce
boundary condition: true
is encoded by: hsa:197258
type: Species
initial amount: NaN
initial concentration: NaN
constant: false
is: SBO:0000252
name: FUK
is: Q8N0W3
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_51a9d7fa_56d3_4347_89a0_410e293ff5d3
constant: false
is: Q15392
is: SBO:0000252
boundary condition: true
has only substance units: false
type: Species
is encoded by: hsa:1718
initial amount: NaN
name: DHCR24
initial concentration: NaN

metaR MACOXO
product: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (218.1) or (221.1) or (4129.1) or (222.1) or (220.1) SUBSYSTEM: Histidine metabolism EC Number: 1.2.1.5 Confidence Level: 4 AUTHORS: PMID:10344773 NOTES:SAB added 2 h to balance--not certain
type: Reaction
is: SBO:0000176
reversible: false
is version of: http://identifiers.org/ec-code/1.2.1.5
name: 3-Methylimidazole acetaldehyde:NAD+ oxidoreductase
reactant: MODEL1310110001#
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.4.3.4
is described by: ECO:0000269

metaM ascb L c
name: L-ascorbate
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C6H7O6 CHARGE: -1 INCHI: InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/p-1/t2-,5+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00074
is: HMDB00044
is: CHEBI:38290
type: Species
constant: false
is: SBO:0000247
initial amount: NaN
boundary condition: false

metaM clpndcoa x
initial concentration: 1.0
notes: FORMULA: C43H64N7O17P3S CHARGE: -4 INCHI: InChI=1/C43H68N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-34(52)71-27-26-45-33(51)24-25-46-41(55)38(54)43(2,3)29-64-70(61,62)67-69(59,60)63-28-32-37(66-68(56,57)58)36(53)42(65-32)50-31-49-35-39(44)47-30-48-40(35)50/h5-6,8-9,11-12,14-15,17-18,30-32,36-38,42,53-54H,4,7,10,13,16,19-29H2,1-3H3,(H,45,51)(H,46,55)(H,59,60)(H,61,62)(H2,44,47,48)(H2,56,57,58)/p-4/b6-5-,9-8-,12-11-,15-14-,18-17-/t32-,36+,37+,38?,42-/m0/s1
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/47205476
type: Species
initial amount: NaN
has only substance units: false
name: clupanodonyl CoA
is: C16166
constant: false
boundary condition: false
is: HMDB06267

metaR r2352
is described by: ECO:0000000
reversible: true
type: Reaction
name: Organic anion transporter 5 Utilized transport
fast: false
reactant: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:11023036,PMID:12739169,PMID:12856180,PMID:12883891,PMID:1554704,PMID:18021224,PMID:4553030,PMID:793184,PMID:8725559,PMID:8781017 NOTES:
kinetic law: MODEL1310110001#
product: MODEL1310110001#

metaR C161CRNt
reversible: false
fast: false
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:TDV
is: SBO:0000185
name: C161 transport into the mitochondria
modifier: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_1467ba67_ccfb_490d_994e_3830a16bf174
name: PIGV
is encoded by: hsa:55650
initial amount: NaN
has only substance units: false
initial concentration: NaN
is: SBO:0000252
boundary condition: true
type: Species
constant: false
is: Q9NUD9

metaR RE3242R
type: Reaction
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: RE3242
modifier: MODEL1310110001#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (64834.1) SUBSYSTEM: Fatty acid synthesis EC Number: Confidence Level: 0 AUTHORS: PMID:10970790 NOTES:
is: SBO:0000176

metaM abt c
notes: FORMULA: C5H12O5 CHARGE: 0 INCHI: InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4-/m0/s1 EHMN_ABBREVIATION: C00532
initial amount: NaN
name: L-arabinitol
boundary condition: false
is: CHEBI:18403
constant: false
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
type: Species
is: HMDB01851

metaM 3hexdtricoa x
is: SBO:0000247
initial amount: NaN
type: Species
name: 3,7,10-hexadecatrienoylcoa
notes: FORMULA: C37H56N7O17P3S CHARGE: -4
is: HMDB02288
constant: false
has only substance units: false
boundary condition: false
initial concentration: 1.0

metaR AG13T3g
kinetic law: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.149
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110001#
reactant: MODEL1310110001#
reversible: false
notes: GENE_ASSOCIATION: (10331.1) or (11041.1) or (374907.2) or (10678.1) or (79369.1) or (374907.1) or (10678.2) or (93010.1) or (146712.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
modifier: MODEL1310110001#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
type: Reaction

metaR r1880
kinetic law: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110001#
is described by: ECO:0000000
fast: false
type: Reaction
name: Y+LAT2 Utilized transport
reversible: false
is: SBO:0000185
reactant: MODEL1310110001#

metaR EX doco13ac
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for docosenoic acid (C22:1)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_c649f94f_a1ae_4e5d_90c1_2562d4be62f7
is: SBO:0000252
boundary condition: true
type: Species
name: B4GALT2
initial concentration: NaN
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:8704

metaR TETPENT6COAtx
name: fatty acid intracellular transport
product: MODEL1310110001#
fast: false
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 0 AUTHORS: NOTES:interaction between peroxisomes and ER (some enzymes on the outer membrane) NJ
is described by: ECO:0000000
is: SBO:0000185
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_f4686491_5b71_488c_88f8_1f907e733ea9
boundary condition: true
type: Species
initial concentration: NaN
name: GGH
has only substance units: false
is: SBO:0000252
constant: false
is: Q92820
is encoded by: hsa:8836
initial amount: NaN

metaM hs deg10 l
is: HMDB00127
is: CHEBI:15748
boundary condition: false
name: heparan sulfate, degradation product 10
constant: false
notes: FORMULA: C55H80N3O70S8 CHARGE: -9
type: Species
initial amount: NaN
is: SBO:0000247
has only substance units: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_ff47e63f_8c0a_4c80_8230_70a6b542f072
is: O95954
name: FTCD
initial concentration: NaN
is: SBO:0000252
type: Species
has only substance units: false
is encoded by: hsa:10841
initial amount: NaN
constant: false
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_cc74271f_dd18_487d_a23a_c156429f4978
constant: false
boundary condition: true
has only substance units: false
type: Species
initial amount: NaN
is encoded by: hsa:29968
initial concentration: NaN
name: PSAT1
is: SBO:0000252

metaR EX txa2 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thromboxane A2 exchange
type: Reaction

metaM dha e
boundary condition: false
type: Species
initial amount: NaN
is: CHEBI:16016
has only substance units: false
is: SBO:0000247
is: HMDB01882
constant: false
initial concentration: 1.0
notes: FORMULA: C3H6O3 CHARGE: 0 INCHI: InChI=1S/C3H6O3/c4-1-3(6)2-5/h4-5H,1-2H2 HEPATONET_1.0_ABBREVIATION: HC00175 EHMN_ABBREVIATION: C00184
name: glycerone

metaM udp c
name: UDP
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
is: C00015
initial concentration: 1.0
type: Species
initial amount: NaN
is: CHEBI:58223
boundary condition: false

metaM lys L c
name: L-lysinium(1+)
is: HMDB00182
initial concentration: 1.0
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
has only substance units: false
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
is: CHEBI:32551
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_d5049739_64d6_4533_9f8a_a541c4fabe78
is: Q92521
initial concentration: NaN
has only substance units: false
is: SBO:0000252
constant: false
type: Species
name: PIGB
boundary condition: true
initial amount: NaN
is encoded by: hsa:9488

metaM 5eipencoa m
boundary condition: false
is: http://identifiers.org/pubchem.compound/24892790
notes: FORMULA: C41H60N7O17P3S CHARGE: -4
has only substance units: false
initial concentration: 1.0
initial amount: NaN
is: SBO:0000247
type: Species
constant: false
name: 5,8,11,14,17-eicosapentenoylcoa

metaM itp c
initial amount: NaN
is: CHEBI:57614
is: SBO:0000247
boundary condition: false
type: Species
initial concentration: 1.0
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
constant: false
name: ITP(3-)
has only substance units: false
is: HMDB00189

metaM 3mox4hpac m
is: HMDB05175
name: (4-hydroxy-3-methoxyphenyl)acetaldehyde
type: Species
is: CHEBI:28111
notes: FORMULA: C9H10O3 CHARGE: 0 INCHI: InChI=1S/C9H10O3/c1-12-9-6-7(4-5-10)2-3-8(9)11/h2-3,5-6,11H,4H2,1H3 HEPATONET_1.0_ABBREVIATION: HC01518 EHMN_ABBREVIATION: C05581
initial concentration: 1.0
is: SBO:0000247
has only substance units: false
initial amount: NaN
constant: false
boundary condition: false

metaR PHYHx
notes: GENE_ASSOCIATION: (5264.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.14.11.18 Confidence Level: 4 AUTHORS: PMID:8954107,PMID:9326940 NOTES:NJ
product: MODEL1310110001#
is described by: ECO:0000269
fast: false
type: Reaction
name: Phytanoyl-CoA dioxygenase, peroxisomal
reactant: MODEL1310110001#
reversible: false
is version of: http://identifiers.org/ec-code/1.14.11.18
is: SBO:0000176
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#

metaM dmhptcrn m
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
has only substance units: false
is: HMDB06320
constant: false
type: Species
initial amount: NaN
boundary condition: false
name: 2,6 dimethylheptanoyl carnitine
is: SBO:0000247
initial concentration: 1.0

metaR FATP9t
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/6.2.1.3
name: fatty acid electroneutral transport
is version of: http://identifiers.org/ec-code/6.2.1.7
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (10998.1) or (11001.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10479480,PMID:12856180,PMID:15522816 NOTES:electroneutral transport NJ
kinetic law: MODEL1310110001#
is described by: ECO:0000269
fast: false
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000185

metaM 3mob m
constant: false
has only substance units: false
initial amount: NaN
is: HMDB00019
notes: FORMULA: C5H7O3 CHARGE: -1 INCHI: InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)/p-1 HEPATONET_1.0_ABBREVIATION: HC00139 EHMN_ABBREVIATION: C00141
initial concentration: 1.0
is: SBO:0000247
is: CHEBI:11851
type: Species
name: 3-methyl-2-oxobutanoate
boundary condition: false

metaR r2372
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
reversible: true
type: Reaction
is: SBO:0000185
fast: false

metaR EX dhap LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of glycerone phosphate(2-)
type: Reaction

metaR EX leuktrA4 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: leukotriene A4 exchange
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_027fc45b_19b6_43bd_ae95_806b46efcd24
constant: false
boundary condition: true
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
has only substance units: false
name: GGT1
is encoded by: hsa:2678
type: Species
is: P19440

metaR EX trp L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-Tryptophan exchange
type: Reaction

metaR r0774
is version of: http://identifiers.org/ec-code/1.1.1.35
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/4.2.1.17
kinetic law: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (1962.1) or (3033.1) or (3030.1) or (3028.1) or (3295.1) SUBSYSTEM: Unassigned EC Number: 4.1.1.37 Confidence Level: 0 AUTHORS: PMID:17360334 NOTES:
is described by: ECO:0000000
reversible: true
reactant: MODEL1310110001#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.107
fast: false
product: MODEL1310110001#
name: Uroporphyrinogen I carboxy-lyase Porphyrin and chlorophyll metabolism EC:4.1.1.37

metaR DDECE1CRNe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of dodecenoyl carnitine into extra cellular space
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_377f35a0_17fc_4a85_8646_c566d69b84ac
initial amount: NaN
is encoded by: hsa:NOS2A
constant: false
name: _NOS2A_1_e
is: SBO:0000252
initial concentration: NaN
type: Species
has only substance units: false
boundary condition: true

metaM g6p c
has only substance units: false
boundary condition: false
is: SBO:0000247
is: CHEBI:61548
initial concentration: 1.0
initial amount: NaN
is: C00092
notes: FORMULA: C6H11O9P CHARGE: -2 INCHI: "1/C5H11/c1-3-5-4-2/h1,3-5H2,2H3 HEPATONET_1.0_ABBREVIATION: HC00094 EHMN_ABBREVIATION: C00092
name: D-Glucose 6-phosphate
constant: false
type: Species
is: HMDB01401

http://identifiers.org/biomodels.db/MODEL1310110001#_9ce4f1e3_f25c_453c_9b7b_f78d3c0e6568
initial concentration: NaN
is: P27144
name: AK4
boundary condition: true
constant: false
is: SBO:0000252
type: Species
is encoded by: hsa:205
initial amount: NaN
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_68fb0188_80be_4a4c_b19b_0dee58b33004
initial amount: NaN
type: Species
constant: false
initial concentration: NaN
boundary condition: true
is: B7Z2M9
name: DGKZ
is: SBO:0000252
has only substance units: false
is encoded by: hsa:8525

metaM arachd c
type: Species
boundary condition: false
is: SBO:0000247
has only substance units: false
is: CHEBI:32395
name: arachidonate
notes: FORMULA: C20H31O2 CHARGE: -1 INCHI: InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/p-1/b7-6-,10-9-,13-12-,16-15-
constant: false
is: HMDB01043
initial concentration: 1.0
initial amount: NaN

metaM trdox c
name: Oxidized thioredoxin
constant: false
is: CHEBI:18191
boundary condition: false
has only substance units: false
initial amount: NaN
notes: FORMULA: X CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00290 EHMN_ABBREVIATION: C00343
type: Species
initial concentration: 1.0
is: SBO:0000247
is: C00343

metaR r2373
is: SBO:0000185
is described by: ECO:0000000
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
product: MODEL1310110001#
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#

metaM ppi e
initial concentration: 1.0
has only substance units: false
type: Species
constant: false
is: C00013
is: HMDB00250
notes: FORMULA: HO7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00023 EHMN_ABBREVIATION: C00013
is: CHEBI:33019
initial amount: NaN
is: SBO:0000247
name: Diphosphate
boundary condition: false

metaR O2tp
product: MODEL1310110001#
is: SBO:0000185
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
reversible: true
kinetic law: MODEL1310110001#
type: Reaction
name: O2 transport, peroxisomal

metaM for e
is: SBO:0000247
notes: FORMULA: CH1O2 CHARGE: -1 INCHI: InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
boundary condition: false
has only substance units: false
type: Species
is: HMDB00142
is: CHEBI:15740
initial concentration: 1.0
name: formate
constant: false
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_137adef7_36fc_4755_a035_f0df12791609
has only substance units: false
boundary condition: true
is: SBO:0000252
name: B3GALT5
initial concentration: NaN
is encoded by: hsa:10317
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_2a0a4f57_3624_47cd_bb3c_acfbbe9a42c4
initial concentration: NaN
name: SLC8A3
initial amount: NaN
is: SBO:0000252
type: Species
constant: false
is encoded by: hsa:6547
has only substance units: false
boundary condition: true

metaR 41R1H2MAE12BOOX
is described by: ECO:0000269
is: SBO:0000176
type: Reaction
reversible: false
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.4.3.4
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
name: 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol:oxygen oxidoreductase(deaminating)(flavin-containing)
fast: false
notes: GENE_ASSOCIATION: (4128.1) or (4129.1) SUBSYSTEM: Tyrosine metabolism EC Number: 1.4.3.4 Confidence Level: 4 AUTHORS: PMID:15035803,PMID:8920635,PMID:9653080 NOTES:SAB

metaM glyphe e
initial amount: NaN
name: Glycylphenylalanine
notes: FORMULA: C11H14N2O3 CHARGE: 0
initial concentration: 1.0
has only substance units: false
is: SBO:0000247
is: http://identifiers.org/pubchem.compound/97415
boundary condition: false
constant: false
type: Species

metaM lys L e
boundary condition: false
is: HMDB00182
name: L-lysinium(1+)
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
has only substance units: false
constant: false
type: Species
is: CHEBI:32551

http://identifiers.org/biomodels.db/MODEL1310110001#_9ff77d83_f07d_4b03_8e4d_42c7e4ed6fee
type: Species
name: PEMT
initial concentration: NaN
is encoded by: hsa:10400
is: SBO:0000252
is: Q9UBM1
initial amount: NaN
has only substance units: false
boundary condition: true
constant: false

metaM udp e
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
is: HMDB00295
boundary condition: false
constant: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
is: CHEBI:58223
has only substance units: false
type: Species
name: UDP(3-)

http://identifiers.org/biomodels.db/MODEL1310110001#_35d27a92_5cb9_45af_a340_0008e7a20110
initial amount: NaN
is: Q8N4E7
is encoded by: hsa:94033
boundary condition: true
is: SBO:0000252
name: FTMT
has only substance units: false
initial concentration: NaN
type: Species
constant: false

metaR DCK1n
is version of: http://identifiers.org/ec-code/2.7.1.74
is described by: ECO:0000269
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (1633.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.1.74 Confidence Level: 4 AUTHORS: PMID:10387103,PMID:12535661,PMID:9342341 NOTES:IT (2.7.1.74)
reversible: true
type: Reaction
name: Deoxycytidine kinase, nuclear (ATP)
reactant: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000176
modifier: MODEL1310110001#
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_6467b05d_84cf_4c77_853e_e1b83115f464
is encoded by: hsa:3945
boundary condition: true
initial amount: NaN
initial concentration: NaN
constant: false
is encoded by: hsa:3939
has only substance units: false
type: Species
name: LDHA:LDHB
has part: P07195
has part: P00338
is: SBO:0000297

metaR EX CE5854 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: gama-CEHC-glucuronide exchange
type: Reaction

metaR EX his L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-histidine
type: Reaction

metaR CERT1gt
reversible: true
product: MODEL1310110001#
is: SBO:0000185
name: ceramide transport protein
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.11.1
is described by: ECO:0000304
type: Reaction
notes: GENE_ASSOCIATION: (10087.1) SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 2 AUTHORS: PMID:12803919,PMID:14685229,PMID:15596449,PMID:15907394 NOTES:non-vesicular intracellular transport of ceramide
fast: false

metaR r2374
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
product: MODEL1310110001#
is described by: ECO:0000000
reactant: MODEL1310110001#
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110001#
reversible: true
fast: false

metaR EX CE5853 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: alpha-CEHC-glucuronide exchange
type: Reaction

metaR C181OHc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of 3-hydroxyoctadecenoylcarnitinec
type: Reaction

metaM dcacoa x
name: Decanoyl-CoA (n-C10:0CoA)
constant: false
initial amount: NaN
boundary condition: false
type: Species
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
initial concentration: 1.0
has only substance units: false
is: C05274
is: HMDB06404
is: SBO:0000247
is: CHEBI:61430

metaM sucsal m
initial concentration: 1.0
is: SBO:0000247
constant: false
boundary condition: false
is: CHEBI:57706
name: Succinic semialdehyde
initial amount: NaN
has only substance units: false
notes: FORMULA: C4H5O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00210 EHMN_ABBREVIATION: C00232
is: HMDB01259
type: Species

metaR FAOXC225m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_6120a177_03c8_46db_b8af_26293b437c07
is: SBO:0000252
has only substance units: false
initial amount: NaN
type: Species
boundary condition: true
is encoded by: hsa:6522
name: SLC4A2
constant: false
initial concentration: NaN
is: F8W682

http://identifiers.org/biomodels.db/MODEL1310110001#_1149b151_daad_4a62_8fcd_feea9cf3c18e
type: Species
is: SBO:0000252
name: ALPI
is encoded by: hsa:248
has only substance units: false
boundary condition: true
constant: false
initial concentration: NaN
initial amount: NaN
is: P09923

metaM g1m8masn r
boundary condition: false
is: SBO:0000247
is: C05875
has only substance units: false
constant: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)
notes: FORMULA: C76H127N2O60X CHARGE: 0

metaM glyc m
initial concentration: 1.0
is: CHEBI:17754
boundary condition: false
type: Species
is: SBO:0000247
notes: FORMULA: C3H8O3 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00114 EHMN_ABBREVIATION: C00116
name: Glycerol
is: HMDB00131
is: C00116
constant: false
initial amount: NaN
has only substance units: false

metaM cs e deg1 l
is: HMDB00868
initial amount: NaN
constant: false
is: SBO:0000247
is: CHEBI:57737
initial concentration: 1.0
type: Species
notes: FORMULA: C45H65N2O52S5 CHARGE: -7
has only substance units: false
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 1
boundary condition: false

metaR RE1796R
reversible: true
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.145
name: RE1796
type: Reaction
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
modifier: MODEL1310110001#
is: SBO:0000176

metaM didp c
type: Species
is: SBO:0000247
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: HMDB03536
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: CHEBI:28823
name: dIDP
initial amount: NaN

metaR DTMPK
fast: false
type: Reaction
is described by: ECO:0000269
reversible: true
reactant: MODEL1310110001#
name: dTMP kinase
is version of: http://identifiers.org/ec-code/2.7.4.9
notes: GENE_ASSOCIATION: (1841.1) SUBSYSTEM: Nucleotide interconversion EC Number: Confidence Level: 4 AUTHORS: NOTES:
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#

metaM glyphe c
notes: FORMULA: C11H14N2O3 CHARGE: 0
is: http://identifiers.org/pubchem.compound/97415
is: SBO:0000247
initial concentration: 1.0
constant: false
initial amount: NaN
name: Glycylphenylalanine
type: Species
has only substance units: false
boundary condition: false

metaR PRPPS
is described by: ECO:0000000
product: MODEL1310110001#
type: Reaction
is: SBO:0000176
name: phosphoribosylpyrophosphate synthetase
fast: false
notes: GENE_ASSOCIATION: (221823.2) or (5631.1) or (221823.1) or (5634.1) SUBSYSTEM: Pentose phosphate pathway EC Number: Confidence Level: 0 AUTHORS: NOTES:
is version of: http://identifiers.org/ec-code/2.7.6.1
reversible: true
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#

metaM dhea c
name: 3beta-hydroxyandrost-5-en-17-one
is: SBO:0000247
has only substance units: false
constant: false
notes: FORMULA: C19H28O2 CHARGE: 0 INCHI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1 EHMN_ABBREVIATION: C01227
type: Species
initial concentration: 1.0
boundary condition: false
initial amount: NaN
is: HMDB00077
is: CHEBI:28689

metaR CYTDn
name: cytidine deaminase, nuclear
is: SBO:0000176
modifier: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000254
product: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/3.5.4.5
reversible: false
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (57379.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.5.4.5 Confidence Level: 2 AUTHORS: PMID:15087440 NOTES:
type: Reaction

metaR r2375
kinetic law: MODEL1310110001#
fast: false
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
product: MODEL1310110001#
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
reactant: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000

metaM but c
initial concentration: 1.0
initial amount: NaN
name: butyrate
is: SBO:0000247
constant: false
is: HMDB00039
boundary condition: false
has only substance units: false
type: Species
is: CHEBI:17968
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246

metaR SIAASEly
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: N-glycan degradation EC Number: 3.2.1.18 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.1.6.4
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.2.1.18
fast: false
is version of: http://identifiers.org/ec-code/3.2.1.23
is described by: ECO:0000000
is: SBO:0000176
kinetic law: MODEL1310110001#
reversible: false
type: Reaction
name: sialidase, lysosomal

metaM itp e
is: SBO:0000247
has only substance units: false
initial amount: NaN
notes: FORMULA: C10H11N4O14P3 CHARGE: -4 INCHI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/p-3/t4-,6-,7-,10-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00084 EHMN_ABBREVIATION: C00081
initial concentration: 1.0
type: Species
is: HMDB00189
constant: false
name: ITP(3-)
boundary condition: false
is: CHEBI:57614

http://identifiers.org/biomodels.db/MODEL1310110001#_97c15865_a0f4_4bd3_9c5c_a829e991262c
is: SBO:0000252
initial concentration: NaN
initial amount: NaN
constant: false
type: Species
boundary condition: true
has only substance units: false
name: _MBOAT5_1_c
is encoded by: hsa:MBOAT5

metaR XOLDIOLONEt
reactant: MODEL1310110001#
product: MODEL1310110001#
reversible: true
is: SBO:0000185
fast: false
type: Reaction
kinetic law: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
name: lipid, flip-flop intracellular transport

http://identifiers.org/biomodels.db/MODEL1310110001#_55fa27f9_2dd8_4601_93c8_5b668cf996f6
is: P37268
name: FDFT1
boundary condition: true
initial amount: NaN
initial concentration: NaN
type: Species
is encoded by: hsa:2222
constant: false
has only substance units: false
is: SBO:0000252

metaM prgnlone m
constant: false
is: SBO:0000247
has only substance units: false
is: CHEBI:16581
initial concentration: 1.0
type: Species
boundary condition: false
is: HMDB00253
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
name: pregnenolone
initial amount: NaN

metaM udp g
name: UDP(3-)
notes: FORMULA: C9H11N2O12P2 CHARGE: -3 INCHI: InChI=1S/C9H14N2O12P2/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00025 EHMN_ABBREVIATION: C00015
constant: false
is: HMDB00295
initial amount: NaN
is: CHEBI:58223
is: SBO:0000247
type: Species
boundary condition: false
initial concentration: 1.0
has only substance units: false

metaR RE1796M
reversible: true
fast: false
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.145
name: RE1796
type: Reaction
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (3283.1) or (3284.1) SUBSYSTEM: Bile acid synthesis EC Number: 5.3.3.1 Confidence Level: 0 AUTHORS: PMID:10599696,PMID:11067870,PMID:11454857,PMID:1401999 NOTES:
is described by: ECO:0000000
modifier: MODEL1310110001#
is: SBO:0000176
product: MODEL1310110001#

metaM hs deg21 l
boundary condition: false
name: IdoA2S-beta-1,4-GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
is: SBO:0000247
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: CHEBI:16126
initial concentration: 1.0
notes: FORMULA: C37H55NO38S2 CHARGE: -4

metaR CSAPASEly
reactant: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000176
reversible: false
type: Reaction
name: chondroitin sulfate A proteoglycan protease, lysosome (endosome)
kinetic law: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Chondroitin sulfate degradation EC Number: Confidence Level: 1 AUTHORS: PMID:8993162 NOTES:Note that this reaction occurs in the endosome during endocytosis, but has been compartmentalized as lysosomal. NCD

metaR FAOXC205C184x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C20:5-->C18:4)x
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_9589a982_901c_4f66_ad34_785db3851fb9
is encoded by: hsa:8503
has only substance units: false
type: Species
initial amount: NaN
is: SBO:0000252
initial concentration: NaN
name: PIK3R3
constant: false
boundary condition: true
is: Q92569

metaM noncoa m
constant: false
is: SBO:0000247
notes: FORMULA: C30H48N7O17P3S CHARGE: -4
initial amount: NaN
type: Species
has only substance units: false
name: nonanoylcoa
is: C01942
boundary condition: false
initial concentration: 1.0
is: HMDB13028

metaR HSAT1ly
fast: false
type: Reaction
product: MODEL1310110001#
name: heparan-glucosaminide N-acetyltransferase, lysosomal
is described by: ECO:0000000
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 2.3.1.78 Confidence Level: 4 AUTHORS: PMID:15591281,PMID:8993162 NOTES:The proton is located in the lysosome since it comes from oxidation of the NH3+ group in glucosamine. This reaction assumes that the other proton liberated from glucosamine reduces coa in the cytosol. NCD

metaR G14T20g
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (8703.1) or (2683.1) or (8704.2) or (8704.1) or (9334.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
reactant: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.4.1.90
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.4.1.22
product: MODEL1310110001#
is described by: ECO:0000000

metaR RE1897C
is: SBO:0000176
name: RE1897
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Urea cycle EC Number: 2.5.1.46 Confidence Level: 0 AUTHORS: PMID:9188485 NOTES:
type: Reaction
kinetic law: MODEL1310110001#
reversible: true
is described by: ECO:0000000
reactant: MODEL1310110001#
fast: false

metaM 6hoxmelatn c
is: http://identifiers.org/pubchem.compound/7954
notes: FORMULA: C13H16N2O3 CHARGE: 0 INCHI: InChI=1/C13H16N2O3/c1-8(16)14-4-3-9-7-15-11-6-12(17)13(18-2)5-10(9)11/h5-7,15,17H,3-4H2,1-2H3,(H,14,16) EHMN_ABBREVIATION: C05643
is: C05643
boundary condition: false
name: 6-Hydroxymelatonin
has only substance units: false
initial amount: NaN
is: HMDB04081
type: Species
constant: false
is: SBO:0000247
initial concentration: 1.0

metaR O2tm
reversible: true
name: O2 transport (diffusion)
type: Reaction
reactant: MODEL1310110001#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:2551143 NOTES:IF
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000

metaR SMS
is described by: ECO:0000269
name: Sphingomyelin synthase (homo sapiens)
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.8.27
product: MODEL1310110001#
reversible: false
type: Reaction
is: SBO:0000176
fast: false
notes: GENE_ASSOCIATION: (259230.1) SUBSYSTEM: Sphingolipid metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:14685263 NOTES:NJ
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_710b8e60_567c_4db3_aaac_a0cbbaa14193
initial amount: NaN
initial concentration: NaN
boundary condition: true
is encoded by: hsa:6569
name: SLC34A1
is: SBO:0000252
has only substance units: false
type: Species
constant: false
is: Q7Z725

metaR S6TASE10ly
is version of: http://identifiers.org/ec-code/3.2.1.23
is: SBO:0000176
is described by: ECO:0000000
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/3.4.16.5
modifier: MODEL1310110001#
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
fast: false
notes: GENE_ASSOCIATION: (5476.1) and (2720.1) and (2588.1) and (4758.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.1.6.4 Confidence Level: 4 AUTHORS: PMID:11550799,PMID:1755850,PMID:1794986,PMID:1953646,PMID:2111707,PMID:3143362,PMID:39554,PMID:7213753,PMID:7575473,PMID:8985184,PMID:9020182,PMID:9054950 NOTES:NCD
name: galactose-6-sulfate sulfatase, lysosomal
is version of: http://identifiers.org/ec-code/3.2.1.18
type: Reaction
is version of: http://identifiers.org/ec-code/3.1.6.4

metaM gal l
has only substance units: false
boundary condition: false
initial concentration: 1.0
initial amount: NaN
is: HMDB00143
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC00122 EHMN_ABBREVIATION: C00124
is: CHEBI:12936
is: SBO:0000247
name: D-galactose
constant: false

metaM sphs1p e
is: HMDB00277
boundary condition: false
is: CHEBI:60119
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
type: Species
initial concentration: 1.0
has only substance units: false
constant: false
name: sphingosine 1-phosphate(1-)
is: SBO:0000247
initial amount: NaN

metaM ksii core2 deg4 l
initial amount: NaN
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
is: HMDB01354
notes: FORMULA: C58H95N5O43SX CHARGE: -1
type: Species
constant: false
name: keratan sulfate II (core 2-linked), degradation product 4
has only substance units: false
is: CHEBI:57455

metaM inost e
initial amount: NaN
type: Species
name: myo-inositol
is: HMDB00211
is: CHEBI:17268
is: SBO:0000247
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
boundary condition: false
has only substance units: false
constant: false
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_35781147_e565_42a6_9f0b_9dd57fe66814
is encoded by: hsa:5281
is: SBO:0000297
has only substance units: false
initial amount: NaN
name: PIGF:PIGO
constant: false
has part: Q6IB04
boundary condition: true
type: Species
is encoded by: hsa:84720
initial concentration: NaN

metaM but e
type: Species
is: CHEBI:17968
is: HMDB00039
boundary condition: false
initial concentration: 1.0
has only substance units: false
constant: false
is: SBO:0000247
notes: FORMULA: C4H7O2 CHARGE: -1 INCHI: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/p-1 HEPATONET_1.0_ABBREVIATION: HC00223 EHMN_ABBREVIATION: C00246
name: butyrate
initial amount: NaN

metaR r0779
is described by: ECO:0000000
name: 3-Hydroxy-2-methylpropanoyl-CoA hydrolase EC:3.1.2.4
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.35
is version of: http://identifiers.org/ec-code/4.2.1.17
is: SBO:0000176
notes: GENE_ASSOCIATION: (1892.1) or (1962.1) or (3030.1) SUBSYSTEM: Unassigned EC Number: 3.1.2.4 Confidence Level: 0 AUTHORS: PMID:11580916,PMID:8188708 NOTES:
fast: false
reversible: false
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_f3817a8f_b6e3_4f38_8966_2582cf1eb434
constant: false
type: Species
initial amount: NaN
is: P43353
boundary condition: true
has only substance units: false
name: ALDH3B1
is: SBO:0000252
is encoded by: hsa:221
initial concentration: NaN

metaR FAOXC161C141m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C16:1-->C14:1)m
type: Reaction

metaR GCCbim
is: SBO:0000176
product: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/1.4.4.2
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) SUBSYSTEM: Glycine, serine, alanine and threonine metabolism EC Number: 1.8.1.4 Confidence Level: 4 AUTHORS: PMID:15355973 NOTES:NCD
kinetic law: MODEL1310110001#
name: glycine-cleavage complex (lipoylprotein) irreversible, mitochondrial
reactant: MODEL1310110001#
modifier: MODEL1310110001#
reversible: false
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.8.1.4
fast: false
is version of: http://identifiers.org/ec-code/2.1.2.10

metaR EX q10 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for ubiquinone
type: Reaction

metaR S6T7g
product: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (23563.2) or (9435.1) or (23563.1) or (10164.1) or (4166.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
kinetic law: MODEL1310110001#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus
type: Reaction
reactant: MODEL1310110001#

metaM cysam c
type: Species
boundary condition: false
initial concentration: 1.0
is: SBO:0000247
is: HMDB02991
is: CHEBI:58029
initial amount: NaN
notes: FORMULA: C2H8NS CHARGE: 1 INCHI: InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2/p+1 HEPATONET_1.0_ABBREVIATION: HC00823 EHMN_ABBREVIATION: C01678
has only substance units: false
name: cysteaminium
constant: false

metaM phyt x
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB00801
is: CHEBI:37257
initial amount: NaN
name: phytanate
initial concentration: 1.0
type: Species
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
constant: false

metaM tetpent6coa x
type: Species
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C45H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C45H72N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-36(54)73-29-28-47-35(53)26-27-48-43(57)40(56)45(2,3)31-66-72(63,64)69-71(61,62)65-30-34-39(68-70(58,59)60)38(55)44(67-34)52-33-51-37-41(46)49-32-50-42(37)52/h8-9,11-12,14-15,17-18,20-21,32-34,38-40,44,55-56H,4-7,10,13,16,19,22-31H2,1-3H3,(H,47,53)(H,48,57)(H,61,62)(H,63,64)(H2,46,49,50)(H2,58,59,60)/b9-8-,12-11-,15-14-,18-17-,21-20-/t34-,38-,39-,40?,44-/m1/s1
is: C16172
has only substance units: false
constant: false
is: SBO:0000247
name: tetracosapentaenoyl coenzyme A, n-6
boundary condition: false

metaR r0921
kinetic law: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#
reversible: false
name: Postulated transport reaction
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:12006583,PMID:1260500,PMID:12838422,PMID:14747464,PMID:16595656,PMID:168203,PMID:17187757,PMID:17279066,PMID:3728675,PMID:6778226,PMID:7419607,PMID:7479738,PMID:8438778 NOTES:
type: Reaction
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_0eddd9cb_8a99_48cb_9497_33dfe4c9fd97
name: XYLB
initial concentration: NaN
boundary condition: true
constant: false
type: Species
is: O75191
is encoded by: hsa:9942
is: SBO:0000252
has only substance units: false
initial amount: NaN

metaR EX 3aib LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: L-3-Amino-isobutanoate exchange
type: Reaction

metaM subeac x
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C8H12O4 CHARGE: -2
is: SBO:0000247
is: HMDB00893
has only substance units: false
boundary condition: false
name: suberic acid
type: Species

metaR DMHPTCRNte
reactant: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:9299016,PMID:9819701 NOTES:unknown mechanism for transport -see PMID 9299016, identifies 2,6-dimethylheptanoyl carnitine in the urine! NJ
type: Reaction
name: 2,6 dimethylheptanoyl carnitine transport
reversible: true
is described by: ECO:0000000

metaR GULLACter
fast: false
name: gulonolactone endoplasmic reticular transport
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: PMID:11458272 NOTES:NCD
is: SBO:0000185
reversible: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#

metaM nicrnt c
initial concentration: 1.0
is: CHEBI:57502
constant: false
notes: FORMULA: C11H12NO9P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00703 EHMN_ABBREVIATION: C01185
name: Nicotinate D-ribonucleotide
has only substance units: false
is: SBO:0000247
boundary condition: false
is: HMDB01132
initial amount: NaN
type: Species
is: C01185

http://identifiers.org/biomodels.db/MODEL1310110001#_39c48b41_ba6d_46d5_93bb_f6d960d82231
constant: false
initial amount: NaN
type: Species
is: Q9BY32
is: SBO:0000252
initial concentration: NaN
boundary condition: true
has only substance units: false
name: ITPA
is encoded by: hsa:3704

metaR UMPK4n
is: SBO:0000176
reversible: true
is described by: ECO:0000269
fast: false
name: UMP kinase (GTP),nuclear
is version of: http://identifiers.org/ec-code/2.7.4.14
product: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (51727.1) SUBSYSTEM: Nucleotide interconversion EC Number: 2.7.4.14 Confidence Level: 4 AUTHORS: PMID:10462544,PMID:11912132 NOTES:
kinetic law: MODEL1310110001#

metaR HDDACBP
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of (S)-3-Hydroxydodecanoyl-CoA from mitochondria into the cytosol
type: Reaction

metaR 3HCO3 NAt
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID: 11875267, PMID: 18077606. NOTES:Na/hco3 co-transporter, expressed at the basolateral side, meant for uptake of hco3, expressed highly in the intestine (NBC1).
product: MODEL1310110001#
is: SBO:0000185
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
is described by: ECO:0000134
name: 3HCO3_NAt

metaR LNLNCACPT2
is: SBO:0000176
reversible: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
is described by: ECO:0000000
modifier: MODEL1310110001#
type: Reaction
name: carnitine transferase

http://identifiers.org/biomodels.db/MODEL1310110001#_5b17621e_a9bb_402f_8d90_709c5624e08a
type: Species
is: SBO:0000252
initial amount: NaN
has only substance units: false
constant: false
initial concentration: NaN
name: NT5C2
is encoded by: hsa:22978
is: P49902
boundary condition: true

metaR DM T antigen g
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 0 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: DM T antigen(g)
type: Reaction

metaR GLCAASE4ly
is version of: http://identifiers.org/ec-code/3.2.1.31
reversible: false
reactant: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
is: SBO:0000176
type: Reaction
name: beta-glucuronidase, lysosomal
product: MODEL1310110001#
is described by: ECO:0000000
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (2990.1) SUBSYSTEM: Chondroitin sulfate degradation EC Number: 3.2.1.31 Confidence Level: 4 AUTHORS: PMID:3468507,PMID:3924735,PMID:3987656 NOTES:NCD

metaR r1078
fast: false
is: SBO:0000185
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
reversible: false
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:10049700,PMID:10574970,PMID:11389679,PMID:11557028,PMID:11564694,PMID:12824232,PMID:12930836,PMID:14574404,PMID:16288981,PMID:911815 NOTES:
name: Vesicular transport
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_1ab16697_dcf7_4f69_a4eb_0f3425f6bc3a
is encoded by: hsa:8050
has only substance units: false
is: SBO:0000252
constant: false
initial amount: NaN
initial concentration: NaN
boundary condition: true
name: PDHX
type: Species
is: O00330

metaR 1PPDCRp
name: delta1-piperideine-2-carboxylate reductase, perixosomal
is: SBO:0000176
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Lysine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:10485319,PMID:10772957 NOTES:MM
reversible: false
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
type: Reaction

metaM inost c
name: myo-inositol
constant: false
type: Species
initial amount: NaN
is: CHEBI:17268
is: HMDB00211
is: SBO:0000247
has only substance units: false
notes: FORMULA: C6H12O6 CHARGE: 0 INCHI: InChI=1S/C6H12O6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-12H/t1-,2-,3-,4+,5-,6- HEPATONET_1.0_ABBREVIATION: HC00135 EHMN_ABBREVIATION: C00137
boundary condition: false
initial concentration: 1.0

metaR ADEt
kinetic law: MODEL1310110001#
is: SBO:0000185
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (3177.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12006583,PMID:12838422 NOTES:NCD
type: Reaction
reactant: MODEL1310110001#
name: adenine reversible transport, cytosol
is described by: ECO:0000269
modifier: MODEL1310110001#
fast: false
reversible: true

metaM sphs1p c
boundary condition: false
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
initial amount: NaN
initial concentration: 1.0
is: HMDB00277
type: Species
is: CHEBI:60119
has only substance units: false
name: sphingosine 1-phosphate(1-)
constant: false
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_0d7be186_e363_4fbf_9e87_1cf898bef43c
initial amount: NaN
constant: false
has only substance units: false
name: _AI620219_1_m
initial concentration: NaN
type: Species
is encoded by: hsa:AI620219
boundary condition: true
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_9f150049_3f6c_418f_b80d_419e3ee374c8
is: SBO:0000252
name: SLC16A2
is encoded by: hsa:6567
initial amount: NaN
has only substance units: false
boundary condition: true
is: P36021
constant: false
initial concentration: NaN
type: Species

metaR r2371
is described by: ECO:0000000
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172 NOTES:
is: SBO:0000185
product: MODEL1310110001#
type: Reaction
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
fast: false
reversible: true
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#

metaR DHFR
modifier: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/1.5.1.3
product: MODEL1310110001#
name: dihydrofolate reductase
is described by: ECO:0000254
reversible: true
type: Reaction
reactant: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1719.1) SUBSYSTEM: Folate metabolism EC Number: 1.5.1.3 Confidence Level: 2 AUTHORS: PMID:6504041 NOTES:
kinetic law: MODEL1310110001#

metaR O2tn
name: O2 nuclear transport
reactant: MODEL1310110001#
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, nuclear EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
fast: false
is described by: ECO:0000000
reversible: true
type: Reaction
product: MODEL1310110001#
kinetic law: MODEL1310110001#

metaR LNLNCACPT1
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.21
is described by: ECO:0000269
modifier: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
is: SBO:0000176
fast: false
name: carnitine O-palmitoyltransferase
reversible: false
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
reactant: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_0a095f75_1ba7_4cae_bf27_15c0ccfb0e77
name: ALDH4A1
is: SBO:0000252
initial concentration: NaN
boundary condition: true
type: Species
constant: false
is encoded by: hsa:8659
is: P30038
has only substance units: false
initial amount: NaN

metaM ppi c
is: HMDB00250
is: SBO:0000247
notes: FORMULA: HO7P2 CHARGE: -3
is: C00013
has only substance units: false
name: Diphosphate
initial amount: NaN
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:0
type: Species

metaM pyr x
is: SBO:0000247
is: CHEBI:15361
notes: FORMULA: C3H3O3 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00032 EHMN_ABBREVIATION: C00022
type: Species
is: C00022
initial amount: NaN
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/3324
boundary condition: false
constant: false
name: pyruvate
is: HMDB00243
has only substance units: false

metaR SERGLNexR
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110001#
product: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000304
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
fast: false
name: L-Serine/Glutamine reversible exchange
reversible: true
reactant: MODEL1310110001#

metaM dmhptcrn e
notes: FORMULA: C16H35NO4 CHARGE: 0 INCHI: InChI=1/C16H31NO4/c1-12(2)8-7-9-13(3)16(20)21-14(10-15(18)19)11-17(4,5)6/h12-14H,7-11H2,1-6H3
has only substance units: false
is: SBO:0000247
boundary condition: false
type: Species
initial amount: NaN
is: HMDB06320
constant: false
name: 2,6 dimethylheptanoyl carnitine
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_60b24efb_8ad3_4d64_997c_8fab090222d6
has only substance units: false
is encoded by: hsa:9374
boundary condition: true
is: SBO:0000252
type: Species
initial concentration: NaN
initial amount: NaN
is: Q9UMR5
constant: false
name: PPT2

metaR C161CPT22
type: Reaction
modifier: MODEL1310110001#
reversible: false
name: C161 transport into the mitochondria
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.21
reactant: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
is described by: ECO:0000269
fast: false

metaM 3tetd7ecoacrn c
constant: false
type: Species
initial amount: NaN
notes: FORMULA: C21H39NO5 CHARGE: 0
is: HMDB02014
boundary condition: false
name: 3-hydroxy tetradecenoyl-7-carnitine
has only substance units: false
initial concentration: 1.0
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_052eb2d5_4fce_4a38_a68f_c4068cd2efcb
has only substance units: false
is: SBO:0000252
initial concentration: NaN
boundary condition: true
is: Q5JWV8
name: ACSL4
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:2182

metaR sink tetdece1coa LPAREN c RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: AUTHORS: NOTES:
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: TETDECE1COASINK
type: Reaction

metaM tetpent3 c
constant: false
is: HMDB06323
name: tetracosapentaenoic acid, n-3
is: SBO:0000247
type: Species
initial amount: NaN
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
has only substance units: false
boundary condition: false

http://identifiers.org/biomodels.db/MODEL1310110001#_7ce2b099_1064_4a45_abad_134eb3a10033
boundary condition: true
is: P55084
initial amount: NaN
type: Species
initial concentration: NaN
is: SBO:0000252
has only substance units: false
name: HADHB
is encoded by: hsa:3032
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_ce00e221_d312_4c7a_adc6_49bb0048220d
initial concentration: NaN
has only substance units: false
initial amount: NaN
type: Species
is: SBO:0000252
constant: false
is: O43306
name: ADCY6
is encoded by: hsa:112
boundary condition: true

metaR GASNASE3ly
reversible: false
is described by: ECO:0000000
name: glycosylasparaginase, lysosomal
type: Reaction
notes: GENE_ASSOCIATION: (175.1) SUBSYSTEM: Keratan sulfate degradation EC Number: 3.5.1.26 Confidence Level: 4 AUTHORS: PMID:1703489,PMID:2401370,PMID:8002961 NOTES:NCD
modifier: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/3.5.1.26

metaR r0669
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
is: SBO:0000176
notes: GENE_ASSOCIATION: SUBSYSTEM: Valine, leucine, and isoleucine metabolism EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:10671535,PMID:12467702 NOTES:
reversible: false
product: MODEL1310110001#
name: (S)-3-Hydroxyisobutyryl-CoA hydro-lyase Valine, leucine and isoleucine degradation EC:4.2.1.17

http://identifiers.org/biomodels.db/MODEL1310110001#_7a053e5e_1997_4cea_a5ec_c5eedb7960da
initial amount: NaN
is encoded by: hsa:2687
is: P36269
is: SBO:0000252
constant: false
type: Species
initial concentration: NaN
boundary condition: true
name: GGT5
has only substance units: false

metaM CE4794 m
boundary condition: false
type: Species
constant: false
name: cis-6-dodecenoyl-CoA
is: CHEBI:57923
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C33H52N7O17P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-24(42)61-17-16-35-23(41)14-15-36-31(45)28(44)33(2,3)19-54-60(51,52)57-59(49,50)53-18-22-27(56-58(46,47)48)26(43)32(55-22)40-21-39-25-29(34)37-20-38-30(25)40/h8-9,20-22,26-28,32,43-44H,4-7,10-19H2,1-3H3,(H,35,41)(H,36,45)(H,49,50)(H,51,52)(H2,34,37,38)(H2,46,47,48)/p-4/b9-8-/t22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE4794
has only substance units: false
is: SBO:0000247

metaR HSD3A2r
product: MODEL1310110001#
is described by: ECO:0000000
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.225
is: SBO:0000176
kinetic law: MODEL1310110001#
name: 3 alpha-hydroxysteroid dehydrogenase (type 3)
notes: GENE_ASSOCIATION: (1109.1) SUBSYSTEM: Steroid metabolism EC Number: 1.1.1.225 Confidence Level: 0 AUTHORS: PMID:14643063,PMID:7650035 NOTES:Microsomal rxn see PMID: 14643063 substrate specificity still not clear (nad vs nadp) NJ
fast: false
modifier: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#

metaM so3 c
notes: FORMULA: O3S CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
has only substance units: false
initial concentration: 1.0
boundary condition: false
constant: false
name: Sulfite
type: Species
is: SBO:0000247
is: C00094
is: CHEBI:17137
is: HMDB00240
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_18f06703_dd59_4967_972f_881297c2d8bd
name: MAN2A2
constant: false
is encoded by: hsa:4122
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: Q9P1E4
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_1dc9e452_89fe_4504_88de_6f282874d9d6
is: SBO:0000252
boundary condition: true
type: Species
is: P00558
constant: false
has only substance units: false
name: PGK1
initial amount: NaN
is encoded by: hsa:5230
initial concentration: NaN

metaR GLXtm
fast: false
type: Reaction
is described by: ECO:0000000
product: MODEL1310110001#
name: glyoxylate transport, mitochondrial
is: SBO:0000185
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD

metaM CE2431 m
name: cis-deca-4-enoyl-CoA
has only substance units: false
notes: FORMULA: C31H48N7O17P3S CHARGE: -4 INCHI: InChI=1/C31H52N7O17P3S/c1-4-5-6-7-8-9-10-11-22(40)59-15-14-33-21(39)12-13-34-29(43)26(42)31(2,3)17-52-58(49,50)55-57(47,48)51-16-20-25(54-56(44,45)46)24(41)30(53-20)38-19-37-23-27(32)35-18-36-28(23)38/h8-9,18-20,24-26,30,41-42H,4-7,10-17H2,1-3H3,(H,33,39)(H,34,43)(H,47,48)(H,49,50)(H2,32,35,36)(H2,44,45,46)/p-4/b9-8-/t20-,24+,25+,26u,30-/m0/s1 EHMN_ABBREVIATION: CE2431
initial amount: NaN
is: SBO:0000247
type: Species
boundary condition: false
is: CHEBI:57795
initial concentration: 1.0
constant: false

metaR r0812
kinetic law: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.85
is version of: http://identifiers.org/ec-code/2.3.1.41
notes: GENE_ASSOCIATION: (AA177072.1) or (2194.1) or (54995.1) SUBSYSTEM: Purine catabolism EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:18406340,PMID:9759482 NOTES:
is: SBO:0000185
type: Reaction
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.20.1
modifier: MODEL1310110001#
fast: false
reactant: MODEL1310110001#

metaR FAOXC225x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: isomerization(C22:5)x
type: Reaction

metaM didp n
constant: false
is: CHEBI:28823
initial amount: NaN
has only substance units: false
type: Species
initial concentration: 1.0
is: HMDB03536
boundary condition: false
notes: FORMULA: C10H11N4O10P2 CHARGE: -3 INCHI: InChI=1S/C10H14N4O10P2/c15-5-1-7(14-4-13-8-9(14)11-3-12-10(8)16)23-6(5)2-22-26(20,21)24-25(17,18)19/h3-7,15H,1-2H2,(H,20,21)(H,11,12,16)(H2,17,18,19)/t5-,6+,7+/m0/s1 EHMN_ABBREVIATION: C01344
is: SBO:0000247
name: dIDP

metaM ksi deg36 l
type: Species
is: CHEBI:12936
constant: false
initial concentration: 1.0
has only substance units: false
notes: FORMULA: C62H103N4O49S1 CHARGE: -1
boundary condition: false
name: keratan sulfate I, degradation product 36
is: HMDB00143
initial amount: NaN
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_08229686_7dc0_46c3_a715_f400aaa08751
initial concentration: NaN
name: MAN1A2
initial amount: NaN
has only substance units: false
constant: false
is: SBO:0000252
type: Species
boundary condition: true
is encoded by: hsa:10905
is: O60476

http://identifiers.org/biomodels.db/MODEL1310110001#_e2d49e60_879d_40fb_8591_6b93d6315bb0
is encoded by: hsa:9197
is: O00400
has only substance units: false
is: SBO:0000252
constant: false
name: SLC33A1
initial amount: NaN
boundary condition: true
type: Species
initial concentration: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_d889f0be_6ed5_4ea7_ab01_46f5534c1a95
has only substance units: false
type: Species
boundary condition: true
initial amount: NaN
constant: false
has part: P55084
name: HADHA:HADHB
is encoded by: hsa:3032
is encoded by: hsa:3030
initial concentration: NaN
has part: E9KL44
is: SBO:0000297

metaR BPNT
is version of: http://identifiers.org/ec-code/3.1.3.7
type: Reaction
is: SBO:0000176
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (10380.1) SUBSYSTEM: Nucleotide interconversion EC Number: 3.1.3.7 Confidence Level: 4 AUTHORS: PMID:10224133 NOTES:
is described by: ECO:0000269
modifier: MODEL1310110001#
fast: false
reversible: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
name: 3',5'-bisphosphate nucleotidase

metaR EX ahdt LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Exchange of 7,8-dihydroneopterin 3-triphosphate(4-)
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_d9212977_b845_4d98_9f80_415c430bee54
is encoded by: hsa:1375
initial amount: NaN
boundary condition: true
is: SBO:0000252
has only substance units: false
constant: false
initial concentration: NaN
is: B7Z5T8
name: CPT1B
type: Species

metaM gthox c
initial concentration: 1.0
boundary condition: false
is: SBO:0000247
is: C00127
is: HMDB03337
initial amount: NaN
is: CHEBI:58297
type: Species
constant: false
has only substance units: false
name: Oxidized glutathione
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127

http://identifiers.org/biomodels.db/MODEL1310110001#_ff51c0b2_ecaa_493b_9051_1ed06dad33b0
has part: Q92643
is encoded by: hsa:8733
is: SBO:0000297
initial amount: NaN
has part: Q969N2
is encoded by: hsa:94005
boundary condition: true
name: PIGK:PIGU:PIGT:GPAA1:PIGS
is encoded by: hsa:51604
initial concentration: NaN
has part: Q9H490
is encoded by: hsa:10026
constant: false
has only substance units: false
has part: O43292
is encoded by: hsa:128869
type: Species
has part: Q8NBL9

http://identifiers.org/biomodels.db/MODEL1310110001#_05593763_4431_4db0_a3b7_19fb5a160ce9
constant: false
initial amount: NaN
type: Species
is encoded by: hsa:3028
is: Q99714
has only substance units: false
name: HSD17B10
initial concentration: NaN
is: SBO:0000252
boundary condition: true

metaM 3tetd7ecoacrn e
initial amount: NaN
type: Species
is: HMDB02014
notes: FORMULA: C21H39NO5 CHARGE: 0
boundary condition: false
name: 3-hydroxy tetradecenoyl-7-carnitine
is: SBO:0000247
has only substance units: false
initial concentration: 1.0
constant: false

metaR THRGLNexR
is: SBO:0000185
is described by: ECO:0000304
fast: false
name: L-threonine/glycine reversible exchange
type: Reaction
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10734121,PMID:10863037,PMID:14770310 NOTES:
reactant: MODEL1310110001#
modifier: MODEL1310110001#
product: MODEL1310110001#
reversible: true
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_a53e685b_baf0_49c8_9003_ce4c1c190706
boundary condition: true
constant: false
initial amount: NaN
name: SLC18A2
is: SBO:0000252
has only substance units: false
type: Species
is: Q05940
initial concentration: NaN
is encoded by: hsa:6571

metaR H2Otg
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, golgi apparatus EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110001#
type: Reaction
is described by: ECO:0000000
fast: false
reversible: true
product: MODEL1310110001#
name: H2O transport, Golgi apparatus
is: SBO:0000185

metaM tetpent3 e
constant: false
initial amount: NaN
name: tetracosapentaenoic acid, n-3
has only substance units: false
boundary condition: false
is: SBO:0000247
notes: FORMULA: C24H37O2 CHARGE: -1 INCHI: InChI=1/C24H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24(25)26/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-23H2,1H3,(H,25,26)/b4-3-,7-6-,10-9-,13-12-,16-15-
initial concentration: 1.0
type: Species
is: HMDB06323

metaM lys L m
boundary condition: false
constant: false
has only substance units: false
initial amount: NaN
type: Species
initial concentration: 1.0
name: L-lysinium(1+)
is: CHEBI:32551
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
is: HMDB00182
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_5626408f_78d5_43bb_9593_4830a7c609df
initial concentration: NaN
initial amount: NaN
is encoded by: hsa:2182
boundary condition: true
constant: false
name: ACSL4
is: SBO:0000252
is: Q5JWV8
type: Species
has only substance units: false

metaM thcholstoic c
is: CHEBI:18402
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate
has only substance units: false
initial concentration: 1.0
boundary condition: false
type: Species
is: SBO:0000247
initial amount: NaN
is: HMDB03873
notes: FORMULA: C27H45O5 CHARGE: -1 INCHI: InChI=1S/C27H46O5/c1-15(6-5-7-16(2)25(31)32)19-8-9-20-24-21(14-23(30)27(19,20)4)26(3)11-10-18(28)12-17(26)13-22(24)29/h15-24,28-30H,5-14H2,1-4H3,(H,31,32)/t15-,16?,17+,18-,19-,20+,21+,22-,23+,24+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01340 EHMN_ABBREVIATION: C04722
constant: false

metaM gal e
is: HMDB00143
constant: false
is: C00124
initial amount: NaN
has only substance units: false
boundary condition: false
type: Species
notes: FORMULA: C6H12O6 CHARGE: 0
is: CHEBI:0
name: D-Galactose
is: SBO:0000247
initial concentration: 1.0

metaR ACETONEt2
notes: GENE_ASSOCIATION: (6566.1) or (9123.1) or (9194.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10510291,PMID:11101640,PMID:12739169,PMID:7835905,PMID:8476015,PMID:9425115,PMID:9508842,PMID:9649795,PMID:9786900,PMID:9824713 NOTES:NCD
is described by: ECO:0000269
name: acetone transport via proton symport
fast: false
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
is: SBO:0000185
reversible: true
type: Reaction
modifier: MODEL1310110001#
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_cea14067_06c1_4207_aae9_e680c055637a
has only substance units: false
is: P00813
boundary condition: true
is encoded by: hsa:100
initial concentration: NaN
initial amount: NaN
type: Species
name: ADA
constant: false
is: SBO:0000252

metaR TTDCRNt
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
notes: GENE_ASSOCIATION: (788.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
modifier: MODEL1310110001#
product: MODEL1310110001#
reversible: false
name: transport into the mitochondria (carnitine)
is described by: ECO:0000000
is: SBO:0000185
fast: false

metaR RE3367E
is: SBO:0000176
reversible: false
fast: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
name: RE3367
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.4.3.22
is described by: ECO:0000000

metaR NADPHtru
name: NADPH transporter, endoplasmic reticulum
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 1 AUTHORS: NOTES:diffusion - but unidirectional uptake into ER (to avoid loops w/ NAD/NADP) NJ
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
reversible: false
reactant: MODEL1310110001#
is: SBO:0000185
fast: false

metaM L2aadp6sa m
is: HMDB01263
type: Species
notes: FORMULA: C6H11NO3 CHARGE: 0 INCHI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01230 EHMN_ABBREVIATION: C04076
name: L-allysine
initial concentration: 1.0
initial amount: NaN
boundary condition: false
has only substance units: false
is: CHEBI:17917
is: SBO:0000247
constant: false

metaR TETDEC2CRNe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: trnasport of tetradecadienoyl carnitine into extra cellular space
type: Reaction

metaR r1788
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185
product: MODEL1310110001#
name: Y+LAT2 Utilized transport
fast: false

metaR r0668
kinetic law: MODEL1310110001#
reversible: true
fast: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (AI539321.1) or (23475.1) SUBSYSTEM: Unassigned EC Number: 2.7.7.43 Confidence Level: 0 AUTHORS: PMID:1577759,PMID:422125,PMID:4288894,PMID:4803836,PMID:9689047 NOTES:
type: Reaction
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.2.19
modifier: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000176
name: CTP:N-acylneuraminate cytidylyltransferase Aminosugars metabolism EC:2.7.7.43

http://identifiers.org/biomodels.db/MODEL1310110001#_f689e96e_f660_46ed_a08c_440fd7ed354a
constant: false
type: Species
has only substance units: false
is encoded by: hsa:220
is: P47895
name: ALDH1A3
initial amount: NaN
boundary condition: true
initial concentration: NaN
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_a423548d_40f4_450f_b7c4_293563ef5dbf
name: GBA
has only substance units: false
boundary condition: true
is: SBO:0000252
initial amount: NaN
type: Species
constant: false
is encoded by: hsa:2629
initial concentration: NaN

metaM CE1943 e
is: SBO:0000247
type: Species
initial concentration: 1.0
is: CHEBI:30623
name: spermidine dialdehyde
initial amount: NaN
is: HMDB02329
boundary condition: false
constant: false
notes: FORMULA: C7H14NO2 CHARGE: 1 INCHI: InChI=1/C7H13NO2/c9-6-2-1-4-8-5-3-7-10/h6-8H,1-5H2/p+1 EHMN_ABBREVIATION: CE1943
has only substance units: false

metaR SLDt
product: MODEL1310110001#
is: SBO:0000185
reversible: false
type: Reaction
is described by: ECO:0000000
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine and cysteine metabolism EC Number: Confidence Level: 2 AUTHORS: PMID:15758220 NOTES:MM
fast: false
reactant: MODEL1310110001#
name: L-sulfolactate transport (cytosol to extracellular)

metaM hs deg2 l
initial amount: NaN
constant: false
initial concentration: 1.0
is: CHEBI:17180
is: HMDB01352
notes: FORMULA: C79H116N5O96S10 CHARGE: -11
has only substance units: false
name: heparan sulfate, degradation product 2
is: SBO:0000247
boundary condition: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_7372695b_dbb3_4504_a5c6_d908309e81b5
initial amount: NaN
initial concentration: NaN
is: P48426
constant: false
type: Species
is encoded by: hsa:5305
boundary condition: true
name: PIP4K2A
has only substance units: false
is: SBO:0000252

metaM CE5125 x
initial amount: NaN
notes: FORMULA: C40H68N7O17P3S CHARGE: -4 INCHI: InChI=1/C40H72N7O17P3S/c1-25(2)11-8-12-26(3)13-9-14-27(4)15-10-16-28(5)39(52)68-20-19-42-30(48)17-18-43-37(51)34(50)40(6,7)22-61-67(58,59)64-66(56,57)60-21-29-33(63-65(53,54)55)32(49)38(62-29)47-24-46-31-35(41)44-23-45-36(31)47/h23-29,32-34,38,49-50H,8-22H2,1-7H3,(H,42,48)(H,43,51)(H,56,57)(H,58,59)(H2,41,44,45)(H2,53,54,55)/p-4/t26-,27-,28-,29-,32+,33+,34u,38-/m0/s1 EHMN_ABBREVIATION: CE5125
type: Species
is: SBO:0000247
is: HMDB00127
is: CHEBI:15748
name: (2S)-pristanoyl-CoA
boundary condition: false
constant: false
has only substance units: false
initial concentration: 1.0

metaR DHORD9
reversible: false
is version of: http://identifiers.org/ec-code/1.3.5.2
is: SBO:0000185
reactant: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (1723.1) SUBSYSTEM: Pyrimidine synthesis EC Number: 1.3.3.1 Confidence Level: 4 AUTHORS: PMID:10727948,PMID:9693067 NOTES:_06-15-05 - EC 1.3.3.1 IT based on Bader et al, 1998, Prot. Expr. Purif,., 13,414-422 (I guess it is ubiquinone but i am not sure ) (needs FMN as cofactor) v(enzyme is located in inner-membrane of mitochondria, reaction take place in cytosol (Fig. 8 Rawls et al PMID: 10727948 )
is described by: ECO:0000269
name: dihydoorotic acid dehydrogenase (quinone10)
fast: false
kinetic law: MODEL1310110001#
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_3ff65aa1_f646_431d_96c4_43871b9fbd8c
initial amount: NaN
boundary condition: true
type: Species
name: GGT7
is: A0PJJ9
constant: false
initial concentration: NaN
is encoded by: hsa:2686
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_d2ff4b1a_b093_423c_b077_f79396f4978e
is encoded by: hsa:80025
initial concentration: NaN
has only substance units: false
is: Q6P1K9
initial amount: NaN
constant: false
type: Species
boundary condition: true
name: PANK2
is: SBO:0000252

metaR GLYCTO1p
is version of: http://identifiers.org/ec-code/1.1.3.15
notes: GENE_ASSOCIATION: (51179.1) or (54363.1) or (51179.2) SUBSYSTEM: Glyoxylate and dicarboxylate metabolism EC Number: Confidence Level: 4 AUTHORS: PMID:10777549,PMID:4705431,PMID:9038835 NOTES:tv NCD
type: Reaction
is described by: ECO:0000269
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
fast: false
reactant: MODEL1310110001#
product: MODEL1310110001#
name: Glycolate oxidase, peroxisome
is: SBO:0000176
reversible: false

metaM gal c
notes: FORMULA: C6H12O6 CHARGE: 0
is: HMDB00143
is: SBO:0000247
type: Species
initial concentration: 1.0
initial amount: NaN
has only substance units: false
boundary condition: false
name: D-Galactose
is: CHEBI:0
constant: false
is: C00124

metaM xol7ah2al c
is: CHEBI:27428
initial amount: NaN
has only substance units: false
is: HMDB06894
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
type: Species

metaR RE1519M
product: MODEL1310110001#
reversible: true
is version of: http://identifiers.org/ec-code/1.3.3.6
is version of: http://identifiers.org/ec-code/1.3.99.13
fast: false
type: Reaction
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (33.1) or (51.1) SUBSYSTEM: Fatty acid oxidation EC Number: 1.3.99.13 Confidence Level: 0 AUTHORS: PMID:10407780,PMID:11356167,PMID:8973539 NOTES:
modifier: MODEL1310110001#
is: SBO:0000176
reactant: MODEL1310110001#
name: RE1519
is described by: ECO:0000000

metaR EX tcynt LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Thiocyanate exchange
type: Reaction

metaR XOL7AONEtr
kinetic law: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#
reversible: true
is: SBO:0000185
product: MODEL1310110001#
name: lipid, flip-flop intracellular transport
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, endoplasmic reticular EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_2a9bd6b4_a84c_4756_9023_1351233ef09f
is encoded by: hsa:30814
constant: false
type: Species
name: PLA2G2E
is: SBO:0000252
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
is: Q9NZK7

http://identifiers.org/biomodels.db/MODEL1310110001#_9d5d261d_2850_47aa_8ee4_d9b04d81945f
initial concentration: NaN
is encoded by: hsa:132
initial amount: NaN
is: SBO:0000252
is: P55263
boundary condition: true
name: ADK
has only substance units: false
constant: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_271c7428_74fc_474f_93c4_397167f6d174
is encoded by: hsa:8310
initial concentration: NaN
constant: false
initial amount: NaN
has only substance units: false
type: Species
is: O15254
boundary condition: true
name: ACOX3
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_f6b27349_b7a7_43bd_b94d_604ffc433faf
boundary condition: true
has part: Q92535
has part: O94777
is encoded by: hsa:51227
name: PIGP:PIGA:PIGC:PIGH:DPM2:PIGQ
has only substance units: false
constant: false
has part: Q9BRB3
is encoded by: hsa:9091
initial amount: NaN
is encoded by: hsa:5277
is encoded by: hsa:8818
has part: B3KUV7
is encoded by: hsa:5283
initial concentration: NaN
has part: Q14442
is: SBO:0000297
is encoded by: hsa:5279
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_ac689e3d_ebb9_4eb9_a86a_099427d08c91
is: SBO:0000252
name: PANK3
initial concentration: NaN
type: Species
is encoded by: hsa:79646
constant: false
boundary condition: true
initial amount: NaN
is: Q9H999
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_c2fe36f5_d1fe_4f07_9d13_c36d14ac6ba2
boundary condition: true
has only substance units: false
is: O75414
initial concentration: NaN
is encoded by: hsa:10201
constant: false
is: SBO:0000252
initial amount: NaN
name: NME6
type: Species

metaM Rtotal2 c
type: Species
name: R total 2 position
is: SBO:0000247
initial amount: NaN
is: CHEBI:57876
notes: FORMULA: CO2FULLR2 CHARGE: -1
initial concentration: 1.0
boundary condition: false
constant: false
has only substance units: false
is: HMDB01564

metaM dec24dicoa m
initial concentration: 1.0
type: Species
is: SBO:0000247
is: HMDB01168
constant: false
has only substance units: false
name: 2,4-decadienoylcoa
initial amount: NaN
boundary condition: false
notes: FORMULA: C31H46N7O17P3S CHARGE: -4

metaR EX uri LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for Uridine
type: Reaction

metaR r0666
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
reversible: true
name: 2-(Formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming) Purine metabolism EC:6.3.3.1
is version of: http://identifiers.org/ec-code/1.2.4.2
notes: GENE_ASSOCIATION: (4967.1) or (55753.1) SUBSYSTEM: Purine synthesis EC Number: 6.3.3.1 Confidence Level: 0 AUTHORS: PMID:4084560 NOTES:
is described by: ECO:0000000
is: SBO:0000176
product: MODEL1310110001#
fast: false

metaR FAS140COA
notes: GENE_ASSOCIATION: (2194.1) SUBSYSTEM: Fatty acid synthesis EC Number: 2.3.1.86 Confidence Level: 4 AUTHORS: PMID:11756679,PMID:15507492,PMID:2669958 NOTES:NCD
reversible: false
is: SBO:0000176
is version of: http://identifiers.org/ec-code/2.3.1.85
reactant: MODEL1310110001#
is described by: ECO:0000269
modifier: MODEL1310110001#
fast: false
type: Reaction
kinetic law: MODEL1310110001#
name: fatty-acyl-CoA synthase (n-C14:0CoA)
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_895de24d_9496_4b98_a944_34a7ae78a35e
is: SBO:0000252
name: ATP5J
is encoded by: hsa:522
boundary condition: true
constant: false
type: Species
initial concentration: NaN
has only substance units: false
initial amount: NaN

metaR G14T19g
is version of: http://identifiers.org/ec-code/2.4.1.38
notes: GENE_ASSOCIATION: (9334.1) or (8704.1) or (8703.1) or (8704.2) or (2683.1) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.38 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:12512857,PMID:1903938,PMID:3094506,PMID:3144273,PMID:9405390,PMID:9435216 NOTES:Keratan sulfate II biosynthesis NCD
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000176
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/2.4.1.90
fast: false
is version of: http://identifiers.org/ec-code/2.4.1.22
type: Reaction
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase, Golgi
reactant: MODEL1310110001#
product: MODEL1310110001#

metaR S6T12g
reversible: false
notes: GENE_ASSOCIATION: (23563.1) or (9435.1) or (10164.1) or (4166.1) or (23563.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: Confidence Level: 4 AUTHORS: PMID:10330415,PMID:10491328,PMID:10913333,PMID:11278593,PMID:12403612,PMID:12855678,PMID:9722682 NOTES:NCD
fast: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
type: Reaction
is: SBO:0000176
product: MODEL1310110001#
modifier: MODEL1310110001#
is described by: ECO:0000000
name: galactose/N-acetylglucosamine 6-O-sulfotransferase, Golgi apparatus

metaM udpgal c
boundary condition: false
name: UDP-D-galactose(2-)
has only substance units: false
is: CHEBI:58439
type: Species
initial concentration: 1.0
is: HMDB00302
initial amount: NaN
is: SBO:0000247
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
constant: false

metaR BCRNe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of 3-hydroxy butyryl carnitine into extra cellular space
type: Reaction

metaM octa c
type: Species
is: CHEBI:25646
initial concentration: 1.0
boundary condition: false
is: C06423
name: octanoate (n-C8:0)
initial amount: NaN
has only substance units: false
constant: false
notes: FORMULA: C8H15O2 CHARGE: -1
is: HMDB00482
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_aaf42207_d7ed_4faf_a8ab_3f8397e34dcc
is: Q07326
is encoded by: hsa:5281
name: PIGF
constant: false
type: Species
initial concentration: NaN
is: SBO:0000252
boundary condition: true
initial amount: NaN
has only substance units: false

metaR APAT2rm
is described by: ECO:0000212
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (18.1) or (18.2) SUBSYSTEM: beta-Alanine metabolism EC Number: 2.6.19.4 Confidence Level: 1 AUTHORS: PMID:15304357 NOTES:SAB
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
name: 3-Aminopropanoate:2-oxoglutarate aminotransferase (m)
is version of: http://identifiers.org/ec-code/2.6.1.19
modifier: MODEL1310110001#
reversible: true
fast: false
type: Reaction
is: SBO:0000176

metaM thbpt c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C9H15N5O3 CHARGE: 0 INCHI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) HEPATONET_1.0_ABBREVIATION: HC00245 EHMN_ABBREVIATION: C00272
is: HMDB00027
is: CHEBI:15372
has only substance units: false
initial amount: NaN
constant: false
name: 5,6,7,8-tetrahydrobiopterin
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_633f207e_e61d_4e4f_a97d_0fad1cf59c4a
has only substance units: false
is: SBO:0000252
type: Species
initial amount: NaN
is encoded by: hsa:8875
initial concentration: NaN
boundary condition: true
name: VNN2
is: A8K7W0
constant: false

metaR 3AIBt
type: Reaction
reversible: false
product: MODEL1310110001#
fast: false
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: NOTES:HOW? IT
kinetic law: MODEL1310110001#
name: 3-amino-isobutyrate transport
reactant: MODEL1310110001#
is described by: ECO:0000000

http://identifiers.org/biomodels.db/MODEL1310110001#_dd7537bc_1144_4f6c_8d96_35db3b8ef039
boundary condition: true
initial concentration: NaN
constant: false
is: SBO:0000252
has only substance units: false
is encoded by: hsa:23464
name: GCAT
type: Species
initial amount: NaN
is: E2QC23

metaR LNLCCPT2
fast: false
kinetic law: MODEL1310110001#
reversible: false
name: carnitine transferase
is described by: ECO:0000000
is: SBO:0000176
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (1376.1) SUBSYSTEM: Fatty acid oxidation EC Number: Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
product: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.3.1.21

metaM udpgal g
type: Species
is: SBO:0000247
name: UDP-D-galactose(2-)
initial amount: NaN
constant: false
initial concentration: 1.0
notes: FORMULA: C15H22N2O17P2 CHARGE: -2 INCHI: InChI=1S/C15H24N2O17P2/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25)/p-2/t5-,6-,8+,9-,10+,11-,12-,13-,14?/m1/s1 HEPATONET_1.0_ABBREVIATION: HC00057 EHMN_ABBREVIATION: C00052
has only substance units: false
is: HMDB00302
boundary condition: false
is: CHEBI:58439

metaR EX sphs1p LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Sphingosine 1-phosphate exchange
type: Reaction

metaR FAOXC12DCTc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: true
name: transport of dodecanedioyl carnitine into cytosol
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_47cae6f2_732b_4a4e_965f_f274d17c6180
boundary condition: true
is encoded by: hsa:5106
has only substance units: false
initial amount: NaN
initial concentration: NaN
constant: false
type: Species
is: Q16822
name: PCK2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_2cdfd082_0a35_49d5_b990_a2d916659cb4
boundary condition: true
name: _AI620219_1_e
is encoded by: hsa:AI620219
initial concentration: NaN
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
type: Species

metaM gthrd r
initial concentration: 1.0
constant: false
has only substance units: false
type: Species
initial amount: NaN
is: HMDB00125
boundary condition: false
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
is: CHEBI:57925
is: SBO:0000247
name: glutathionate(1-)

metaR FAOXC161C141x
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta xoidation(C16:1-->C14:1)x
type: Reaction

metaR HDD2COAtx
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:unknown mechanism NJ
kinetic law: MODEL1310110001#
type: Reaction
name: hdd2coa intracellular transport
is: SBO:0000185
is described by: ECO:0000000
reactant: MODEL1310110001#
fast: false
reversible: true
product: MODEL1310110001#

metaM Rtotal2 e
is: C00255
initial amount: NaN
name: R total 2 position
constant: false
notes: FORMULA: CO2FULLR2 CHARGE: -1
is: HMDB00244
initial concentration: 1.0
boundary condition: false
has only substance units: false
is: CHEBI:3554
type: Species
is: SBO:0000247

http://identifiers.org/biomodels.db/MODEL1310110001#_651cdd0c_3c27_4316_ac75_cbe0e8288ec9
is: SBO:0000252
type: Species
initial concentration: NaN
is encoded by: hsa:386757
initial amount: NaN
name: SLC6A10P
has only substance units: false
constant: false
boundary condition: true

metaM 3hibutcoa m
has only substance units: false
is: HMDB01052
initial concentration: 1.0
is: CHEBI:28259
is: SBO:0000247
type: Species
constant: false
notes: FORMULA: C25H38N7O18P3S CHARGE: -4 INCHI: InChI=1S/C25H42N7O18P3S/c1-13(8-33)24(38)54-7-6-27-15(34)4-5-28-22(37)19(36)25(2,3)10-47-53(44,45)50-52(42,43)46-9-14-18(49-51(39,40)41)17(35)23(48-14)32-12-31-16-20(26)29-11-30-21(16)32/h11-14,17-19,23,33,35-36H,4-10H2,1-3H3,(H,27,34)(H,28,37)(H,42,43)(H,44,45)(H2,26,29,30)(H2,39,40,41)/t13-,14+,17+,18+,19-,23+/m0/s1 EHMN_ABBREVIATION: C06000
initial amount: NaN
boundary condition: false
name: (S)-3-Hydroxyisobutyryl-CoA

http://identifiers.org/biomodels.db/MODEL1310110001#_70a9dca2_b273_4d3d_8e2e_a4dc2ce80619
boundary condition: true
is: SBO:0000252
constant: false
has only substance units: false
initial amount: NaN
is encoded by: hsa:3098
initial concentration: NaN
name: HK1
is: P19367
type: Species

metaR LNLCCPT1
is version of: http://identifiers.org/ec-code/2.3.1.21
product: MODEL1310110001#
is: SBO:0000176
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) SUBSYSTEM: Fatty acid oxidation EC Number: 2.3.1.21 Confidence Level: 4 AUTHORS: NOTES:NJ
type: Reaction
name: carnitine O-palmitoyltransferase
reactant: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
is described by: ECO:0000269
reversible: false

metaR INSTt4
product: MODEL1310110001#
is: SBO:0000185
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
name: inositol transport via sodium symport
reversible: true
type: Reaction
is described by: ECO:0000269
fast: false
notes: GENE_ASSOCIATION: (6526.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:12748858,PMID:1372904,PMID:15546855,PMID:7537337,PMID:7789985 NOTES:NCD
modifier: MODEL1310110001#

metaM for c
name: Formate
is: CHEBI:15740
constant: false
is: HMDB00142
initial concentration: 1.0
is: C00058
notes: FORMULA: CH1O2 CHARGE: -1 HEPATONET_1.0_ABBREVIATION: HC00061 EHMN_ABBREVIATION: C00058
initial amount: NaN
has only substance units: false
boundary condition: false
is: SBO:0000247
type: Species

metaR r1705
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (8140.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
product: MODEL1310110001#
fast: false
name: Y+LAT2 Utilized transport
type: Reaction
reactant: MODEL1310110001#
is described by: ECO:0000000
reversible: false
kinetic law: MODEL1310110001#
is: SBO:0000185

metaM 4hbz m
has only substance units: false
is: HMDB00500
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C7H5O3 CHARGE: -1 INCHI: InChI=1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)/p-1
type: Species
constant: false
is: SBO:0000247
name: 4-hydroxybenzoate
is: CHEBI:17879
initial amount: NaN

http://identifiers.org/biomodels.db/MODEL1310110001#_14ee2bc7_e3df_465d_a70f_bbf44d667c35
has only substance units: false
is encoded by: hsa:BF195998
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
boundary condition: true
name: _BF195998_1_x
initial amount: NaN

metaR TTDCAFATPc
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: uptake of uptake of Hexadecanoate by the enterocytes by the enterocytes
type: Reaction

metaM e4p c
has only substance units: false
type: Species
is: CHEBI:16897
is: SBO:0000247
is: HMDB01321
boundary condition: false
notes: FORMULA: C4H7O7P CHARGE: -2 HEPATONET_1.0_ABBREVIATION: HC00247 EHMN_ABBREVIATION: C00279
initial amount: NaN
initial concentration: 1.0
name: D-Erythrose 4-phosphate
is: C00279
constant: false

metaR ORNt4m
name: ornithine mitochondrial transport exchange with citruline
modifier: MODEL1310110001#
is described by: ECO:0000269
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (10166.1) or (83884.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 4 AUTHORS: PMID:14598172 NOTES:TDV (ornithine carrier)
is: SBO:0000185
type: Reaction
product: MODEL1310110001#
reactant: MODEL1310110001#
reversible: true
fast: false

metaM octa e
initial amount: NaN
type: Species
is: C06423
is: HMDB00482
initial concentration: 1.0
boundary condition: false
constant: false
is: CHEBI:25646
notes: FORMULA: C8H15O2 CHARGE: -1
name: octanoate (n-C8:0)
is: SBO:0000247
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_74db0502_93e3_4b7d_81fa_f903c97de3ef
initial amount: NaN
is: SBO:0000252
boundary condition: true
initial concentration: NaN
is encoded by: hsa:3036
name: HAS1
constant: false
is: Q8IYH3
has only substance units: false
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_5997ec30_62cf_4a22_8750_e065a3f7df39
initial concentration: NaN
constant: false
initial amount: NaN
type: Species
is: P24752
name: ACAT1
has only substance units: false
is encoded by: hsa:38
is: SBO:0000252
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_f7eb46df_4894_449d_b6b8_e7bf1e383bcc
has only substance units: false
is encoded by: hsa:5315
constant: false
type: Species
initial concentration: NaN
name: PKM2
boundary condition: true
is: B4DNK4
is: SBO:0000252
initial amount: NaN

metaM dcacoa m
is: CHEBI:61430
is: HMDB06404
initial concentration: 1.0
is: C05274
boundary condition: false
has only substance units: false
is: SBO:0000247
notes: FORMULA: C31H50N7O17P3S CHARGE: -4 HEPATONET_1.0_ABBREVIATION: HC01413 EHMN_ABBREVIATION: C05274
constant: false
name: Decanoyl-CoA (n-C10:0CoA)
initial amount: NaN
type: Species

metaR HS3ly
type: Reaction
fast: false
is: SBO:0000176
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
product: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (6448.1) SUBSYSTEM: Heparan sulfate degradation EC Number: 3.10.1.1 Confidence Level: 4 AUTHORS: PMID:7493035,PMID:8993162,PMID:9405287 NOTES:NCD
is version of: http://identifiers.org/ec-code/3.10.1.1
reversible: false
reactant: MODEL1310110001#
name: heparan-N-sulfatase, lysosomal

metaR FORMCOAtx
product: MODEL1310110001#
name: formyl coa transport
reversible: true
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 2 AUTHORS: NOTES:unknown mechanism see Verhoeven 11591435 and clayton 11356171 - added for peroxisomal oxidation of fatty acids NJ
reactant: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#
is described by: ECO:0000000
is: SBO:0000185

metaR r1575
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
reactant: MODEL1310110001#
type: Reaction
product: MODEL1310110001#
reversible: true
fast: false
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_bda9aa5e_09e6_403e_ae40_65536f360817
initial concentration: NaN
boundary condition: true
has only substance units: false
initial amount: NaN
is encoded by: hsa:10449
is: SBO:0000252
type: Species
name: ACAA2
constant: false
is: P42765

http://identifiers.org/biomodels.db/MODEL1310110001#_a4c1d330_1d6f_4592_be04_02c5446cab8c
constant: false
initial concentration: NaN
is: SBO:0000252
has only substance units: false
is encoded by: hsa:51179
initial amount: NaN
boundary condition: true
is: Q9NYQ3
name: HAO2
type: Species

http://identifiers.org/biomodels.db/MODEL1310110001#_e71c083f_08e1_425f_94ad_836b2662110a
constant: false
type: Species
initial amount: NaN
has only substance units: false
boundary condition: true
is encoded by: hsa:6565
is: Q16348
is: SBO:0000252
initial concentration: NaN
name: SLC15A2

metaR FAOXC226C225m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C22:6-->C22:5)m
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_a0e98ce6_a0fd_4ac0_b341_6af003a0566d
type: Species
is encoded by: hsa:7296
initial concentration: NaN
initial amount: NaN
is: SBO:0000252
has only substance units: false
constant: false
boundary condition: true
name: TXNRD1

http://identifiers.org/biomodels.db/MODEL1310110001#_f8cb5bd6_1927_474e_b485_ffebf5f2fd0c
name: SCP2
initial concentration: NaN
is: SBO:0000252
is encoded by: hsa:6342
has only substance units: false
type: Species
constant: false
boundary condition: true
is: C9JC79
initial amount: NaN

metaM sphs1p r
is: SBO:0000247
notes: FORMULA: C18H37NO5P CHARGE: -1 INCHI: InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/p-1/b15-14+/t17-,18+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01702 EHMN_ABBREVIATION: C06124
is: CHEBI:60119
initial concentration: 1.0
constant: false
has only substance units: false
name: sphingosine 1-phosphate(1-)
initial amount: NaN
type: Species
is: HMDB00277
boundary condition: false

metaM crm hs l
has only substance units: false
is: SBO:0000247
initial amount: NaN
boundary condition: false
initial concentration: 1.0
is: CHEBI:52639
name: N-acylsphingosine
type: Species
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
constant: false

metaM ptdcacrn c
is: CHEBI:15811
notes: FORMULA: C22H43NO4 CHARGE: 0 INCHI: InChI=1/C22H43NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)27-20(18-21(24)25)19-23(2,3)4/h20H,5-19H2,1-4H3/t20-/m0/s1
is: HMDB01721
is: SBO:0000247
constant: false
boundary condition: false
has only substance units: false
name: pendtadenoyl carnitine
initial concentration: 1.0
type: Species
initial amount: NaN

metaR EX 3ttetddcoacrn
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for 3-hydroxy trans5,8tetradecadienoyl carnitine
type: Reaction

metaR r0661
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
reversible: false
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
type: Reaction
fast: false
is: SBO:0000176

metaR r1574
fast: false
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is described by: ECO:0000000
reversible: true
type: Reaction
is: SBO:0000185
product: MODEL1310110001#
reactant: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaM phyt c
has only substance units: false
initial amount: NaN
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
type: Species
initial concentration: 1.0
boundary condition: false
constant: false
is: SBO:0000247
name: phytanate
is: HMDB00801
is: CHEBI:37257

metaR S3TASE3ly
is: SBO:0000176
is described by: ECO:0000000
fast: false
type: Reaction
product: MODEL1310110001#
name: N-acetylglucosamine-3-sulfatase, lysosomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Heparan sulfate degradation EC Number: 3.1.6.15 Confidence Level: 2 AUTHORS: PMID:7396957,PMID:8993162 NOTES:NCD
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
reversible: true

metaR MG3er
is: SBO:0000176
type: Reaction
product: MODEL1310110001#
name: mannosyl-oligosaccharide glucosidase, endoplasmic reticulum
is described by: ECO:0000000
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: Confidence Level: 0 AUTHORS: NOTES:EC-3.2.1.- NCD
reversible: false

metaR EX hco3 LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: Bicarbonate exchange
type: Reaction

metaM stcrn c
notes: FORMULA: C25H49NO4 CHARGE: 0 INCHI: InChI=1/C25H49NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-25(29)30-23(21-24(27)28)22-26(2,3)4/h23H,5-22H2,1-4H3
type: Species
is: HMDB00848
constant: false
initial concentration: 1.0
name: stearoylcarnitine
boundary condition: false
initial amount: NaN
is: SBO:0000247
has only substance units: false

metaR PSSA2 hs
type: Reaction
reactant: MODEL1310110001#
is version of: http://identifiers.org/ec-code/2.7.8.29
is: SBO:0000176
fast: false
kinetic law: MODEL1310110001#
is described by: ECO:0000269
name: Phosphatidylserine synthase homo sapiens
product: MODEL1310110001#
modifier: MODEL1310110001#
notes: GENE_ASSOCIATION: (81490.1) SUBSYSTEM: Glycerophospholipid metabolism EC Number: 2.7.8.8 Confidence Level: 4 AUTHORS: NOTES:phosphatidylethanolamine version as substrate NJ
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_db6f3386_db73_429f_9882_5055225a4803
initial amount: NaN
initial concentration: NaN
has only substance units: false
type: Species
is encoded by: hsa:482
is: P14415
boundary condition: true
constant: false
name: ATP1B2
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_aea27e09_9f27_4393_a655_00e170d2ea81
boundary condition: true
initial amount: NaN
has only substance units: false
type: Species
constant: false
initial concentration: NaN
is: SBO:0000252
name: _AA676725_1_c
is encoded by: hsa:AA676725

metaR VLCS2p
name: Very-long-chain-fatty-acid-CoA ligase
reactant: MODEL1310110001#
is described by: ECO:0000304
is: SBO:0000176
is version of: http://identifiers.org/ec-code/6.2.1.3
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: PMID:10479480 NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
reversible: false
product: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
fast: false
kinetic law: MODEL1310110001#

metaR G12MT1 L
type: Reaction
product: MODEL1310110001#
reactant: MODEL1310110001#
name: Glycolipid 1,2-alpha-D-mannosyltransferase (liver)
reversible: false
is: SBO:0000176
is described by: ECO:0000000
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
kinetic law: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_91faa8fc_231d_4d31_ba21_06386c04d8fe
constant: false
initial concentration: NaN
has only substance units: false
initial amount: NaN
boundary condition: true
type: Species
is: SBO:0000252
is encoded by: hsa:AA629629
name: _AA629629_1_m

http://identifiers.org/biomodels.db/MODEL1310110001#_ac8cd966_801b_4934_a790_01294616bf25
name: NSDHL
has only substance units: false
boundary condition: true
initial amount: NaN
is encoded by: hsa:50814
initial concentration: NaN
type: Species
is: SBO:0000252
constant: false
is: Q15738

metaR r0660
is version of: http://identifiers.org/ec-code/1.5.1.2
product: MODEL1310110001#
fast: false
modifier: MODEL1310110001#
name: (S)-3-Hydroxydodecanoyl-CoA hydro-lyase Fatty acid elongation in mitochondria / Fatty acid metabolism EC:4.2.1.17
notes: GENE_ASSOCIATION: (10637.1) or (5831.1) or (29920.1) or (65263.1) SUBSYSTEM: Fatty acid oxidation EC Number: 4.2.1.17 Confidence Level: 0 AUTHORS: PMID:8012501,PMID:8188243 NOTES:
is described by: ECO:0000000
type: Reaction
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
is: SBO:0000176
reversible: true

http://identifiers.org/biomodels.db/MODEL1310110001#_fb3ead74_3a8f_41b2_82ab_f2ed6c7ab994
initial amount: NaN
is: Q5TEK5
has only substance units: false
is: SBO:0000252
is encoded by: hsa:5142
name: PDE4B
constant: false
type: Species
boundary condition: true
initial concentration: NaN

metaM c10dc c
boundary condition: false
name: sebacoyl carnitine
type: Species
has only substance units: false
initial amount: NaN
is: HMDB00651
is: SBO:0000247
notes: FORMULA: C17H30NO6 CHARGE: -1
initial concentration: 1.0
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_96a47d23_0f64_41b5_9b40_ddd033bef716
boundary condition: true
has part: B4DY56
initial concentration: NaN
name: ATP5A1:ATP5B:ATP5C1:ATP5D:ATP5E
has only substance units: false
type: Species
initial amount: NaN
constant: false
is: SBO:0000297
is encoded by: hsa:498

metaR ALR2
is version of: http://identifiers.org/ec-code/1.1.1.2
product: MODEL1310110001#
fast: false
reversible: false
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
modifier: MODEL1310110001#
name: aldose reductase (methylglyoxal)
is: SBO:0000176
type: Reaction
is described by: ECO:0000269
is version of: http://identifiers.org/ec-code/1.1.1.21
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD

metaR C101CPT1
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of decenoylcarnitine
type: Reaction

metaR MI13PP
product: MODEL1310110001#
type: Reaction
reversible: false
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol phosphate metabolism EC Number: 3.1.3.64 Confidence Level: 2 AUTHORS: PMID:2906139 NOTES:NCD
fast: false
is: SBO:0000176
is described by: ECO:0000000
kinetic law: MODEL1310110001#
name: inositol-1,3-bisphosphate 3-phosphatase

http://identifiers.org/biomodels.db/MODEL1310110001#_fc5a4df1_b3cc_4be3_a09f_ba5458c08fb1
is encoded by: hsa:280
initial concentration: NaN
type: Species
name: AMY2B
constant: false
is: P19961
initial amount: NaN
is: SBO:0000252
boundary condition: true
has only substance units: false

metaM phyt e
has only substance units: false
initial amount: NaN
constant: false
type: Species
is: SBO:0000247
notes: FORMULA: C20H39O2 CHARGE: -1 INCHI: InChI=1S/C20H40O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h16-19H,6-15H2,1-5H3,(H,21,22)/p-1 EHMN_ABBREVIATION: C01607
initial concentration: 1.0
is: HMDB00801
boundary condition: false
name: phytanate
is: CHEBI:37257

metaR r1576
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
is described by: ECO:0000000
kinetic law: MODEL1310110001#
type: Reaction
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
reversible: true
reactant: MODEL1310110001#
product: MODEL1310110001#

metaR RE0827E
notes: GENE_ASSOCIATION: (26.1) SUBSYSTEM: Urea cycle EC Number: 1.4.3.6 Confidence Level: 0 AUTHORS: PMID:10047787,PMID:7040832 NOTES:
is: SBO:0000176
type: Reaction
reactant: MODEL1310110001#
product: MODEL1310110001#
fast: false
name: RE0827
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
reversible: false
is described by: ECO:0000000
is version of: http://identifiers.org/ec-code/1.4.3.22

metaM prgnlone c
has only substance units: false
is: SBO:0000247
is: CHEBI:16581
initial concentration: 1.0
boundary condition: false
type: Species
is: HMDB00253
notes: FORMULA: C21H32O2 CHARGE: 0 INCHI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17+,18-,19-,20-,21+/m0/s1 EHMN_ABBREVIATION: C01953
name: pregnenolone
constant: false
initial amount: NaN

metaM xol7ah2al m
name: 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al
initial amount: NaN
constant: false
notes: FORMULA: C27H46O3 CHARGE: 0 INCHI: InChI=1S/C27H46O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h16-25,29-30H,5-15H2,1-4H3/t17?,18-,19+,20-,21-,22+,23+,24-,25+,26+,27-/m1/s1 HEPATONET_1.0_ABBREVIATION: HC01454 EHMN_ABBREVIATION: C05445
has only substance units: false
type: Species
is: SBO:0000247
is: CHEBI:27428
boundary condition: false
is: HMDB06894
initial concentration: 1.0

metaM ksi pre11 g
is: CHEBI:28067
type: Species
is: SBO:0000247
initial amount: NaN
initial concentration: 1.0
notes: FORMULA: C129H208N9O101S3X CHARGE: -4
boundary condition: false
has only substance units: false
constant: false
name: keratan sulfate I biosynthesis, precursor 11

metaM Ssq23epx r
name: (S)-2,3-epoxysqualene
initial concentration: 1.0
is: CHEBI:15441
is: SBO:0000247
boundary condition: false
type: Species
constant: false
initial amount: NaN
notes: FORMULA: C30H50O CHARGE: 0 INCHI: InChI=1S/C30H50O/c1-24(2)14-11-17-27(5)20-12-18-25(3)15-9-10-16-26(4)19-13-21-28(6)22-23-29-30(7,8)31-29/h14-16,20-21,29H,9-13,17-19,22-23H2,1-8H3/b25-15+,26-16+,27-20+,28-21+/t29-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00645 EHMN_ABBREVIATION: C01054
is: HMDB01188
has only substance units: false

http://identifiers.org/biomodels.db/MODEL1310110001#_d6cf5787_aa20_49ec_b666_87dad76159ad
has only substance units: false
type: Species
initial concentration: NaN
constant: false
is encoded by: hsa:9091
boundary condition: true
initial amount: NaN
is: B2RAU6
name: PIGQ
is: SBO:0000252

metaM so3 m
has only substance units: false
constant: false
type: Species
notes: FORMULA: O3S CHARGE: -2 INCHI: InChI=1S/H2O3S/c1-4(2)3/h(H2,1,2,3)/p-1 HEPATONET_1.0_ABBREVIATION: HC00096 EHMN_ABBREVIATION: C00094
initial amount: NaN
is: CHEBI:17137
is: HMDB00240
is: SBO:0000247
name: hydrogensulfite
boundary condition: false
initial concentration: 1.0

metaM dlnlcgcrn m
boundary condition: false
initial amount: NaN
is: HMDB01311
is: CHEBI:16004
type: Species
initial concentration: 1.0
notes: FORMULA: C27H47NO4 CHARGE: 0 INCHI: InChI=1/C27H47NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27(31)32-25(23-26(29)30)24-28(2,3)4/h9-10,12-13,15-16,25H,5-8,11,14,17-24H2,1-4H3
is: SBO:0000247
name: dihomo-gamma-linolenyl carnitine
constant: false
has only substance units: false

metaR ALR3
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.1.1.2
is described by: ECO:0000269
product: MODEL1310110001#
fast: false
reversible: false
is version of: http://identifiers.org/ec-code/1.1.1.21
type: Reaction
notes: GENE_ASSOCIATION: (10327.2) or (8574.1) or (10327.1) or (231.1) SUBSYSTEM: Pyruvate metabolism EC Number: 1.1.1.21 Confidence Level: 4 AUTHORS: PMID:12071861,PMID:1537826,PMID:9823300 NOTES:NCD
name: aldose reductase (acetol)
reactant: MODEL1310110001#
is: SBO:0000176

metaM gthox m
has only substance units: false
is: CHEBI:58297
initial amount: NaN
boundary condition: false
initial concentration: 1.0
constant: false
is: SBO:0000247
notes: FORMULA: C20H30N6O12S2 CHARGE: -2 INCHI: InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/p-2/t9-,10-,11-,12-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00125 EHMN_ABBREVIATION: C00127
is: HMDB03337
type: Species

metaM hedepecoa m
has only substance units: false
is: HMDB02288
initial concentration: 1.0
initial amount: NaN
notes: FORMULA: C37H52N7O17P3S CHARGE: -4
name: 2,4,7,10,13-hexadecapentenoylcoa
is: SBO:0000247
constant: false
type: Species
boundary condition: false

metaM 3hmbcoa m
name: (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA(4-)
has only substance units: false
initial concentration: 1.0
notes: FORMULA: C26H40N7O18P3S CHARGE: -4 INCHI: InChI=1S/C26H44N7O18P3S/c1-13(14(2)34)25(39)55-8-7-28-16(35)5-6-29-23(38)20(37)26(3,4)10-48-54(45,46)51-53(43,44)47-9-15-19(50-52(40,41)42)18(36)24(49-15)33-12-32-17-21(27)30-11-31-22(17)33/h11-15,18-20,24,34,36-37H,5-10H2,1-4H3,(H,28,35)(H,29,38)(H,43,44)(H,45,46)(H2,27,30,31)(H2,40,41,42)/p-4/t13-,14-,15+,18+,19+,20-,24+/m0/s1 HEPATONET_1.0_ABBREVIATION: HC01287 EHMN_ABBREVIATION: C04405
is: HMDB01356
type: Species
is: CHEBI:57312
boundary condition: false
is: SBO:0000247
constant: false
initial amount: NaN

metaR C80CPT1
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: true
name: production of octanoylcarnitine
type: Reaction

metaR PHCDm
is version of: http://identifiers.org/ec-code/1.5.1.12
is: SBO:0000176
fast: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
reactant: MODEL1310110001#
name: L-1-pyrroline-3-hydroxy-5-carboxylate dehydrogenase
is described by: ECO:0000304
reversible: false
notes: GENE_ASSOCIATION: (8659.1) or (8659.2) SUBSYSTEM: Arginine and Proline Metabolism EC Number: 1.5.1.12 Confidence Level: 2 AUTHORS: PMID:12660328,PMID:15849464,PMID:500817 NOTES:NCD

metaM subeac c
type: Species
boundary condition: false
has only substance units: false
initial amount: NaN
constant: false
initial concentration: 1.0
is: SBO:0000247
notes: FORMULA: C8H12O4 CHARGE: -2
is: HMDB00893
name: suberic acid

metaR DGULND
reactant: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose phosphate pathway EC Number: 4.1.1.34 Confidence Level: 2 AUTHORS: PMID:6821187 NOTES:NCD
is: SBO:0000176
type: Reaction
fast: false
name: dehydro-L-gulonate decarboxylase
kinetic law: MODEL1310110001#
reversible: true
is described by: ECO:0000000

metaR ACOX22x
notes: GENE_ASSOCIATION: (8309.1) SUBSYSTEM: Bile acid synthesis EC Number: 1.3.3.6 Confidence Level: 2 AUTHORS: PMID:11181649 NOTES:noted in uniprot to have FAD as cofactor - further reaction specific lit evidence not found to support or contradict, see Baumgart et al PNAS (1996) 93: 13748-13753 analog as per KEGG added NJ
product: MODEL1310110001#
is described by: ECO:0000304
reactant: MODEL1310110001#
reversible: false
modifier: MODEL1310110001#
is: SBO:0000176
name: acyl-Coenzyme A oxidase 2, branched chain
type: Reaction
fast: false
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.17.99.3

metaR AG13T2g
is version of: http://identifiers.org/ec-code/2.4.1.149
is described by: ECO:0000000
product: MODEL1310110001#
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase, Golgi apparatus
reversible: false
notes: GENE_ASSOCIATION: (79369.1) or (374907.1) or (11041.1) or (146712.1) or (374907.2) or (93010.1) or (10331.1) or (10678.1) or (10678.2) SUBSYSTEM: Keratan sulfate synthesis EC Number: 2.4.1.149 Confidence Level: 4 AUTHORS: PMID:10747980,PMID:11042166,PMID:12061784,PMID:12512857,PMID:15560372,PMID:15620693,PMID:9405606 NOTES:NCD
type: Reaction
reactant: MODEL1310110001#
fast: false
is: SBO:0000176

http://identifiers.org/biomodels.db/MODEL1310110001#_93454055_2d06_4ace_a2a9_f2bdae95d250
name: IVD
constant: false
is: SBO:0000252
type: Species
initial concentration: NaN
is: B3KVI7
is encoded by: hsa:3712
has only substance units: false
initial amount: NaN
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_e7ba64e2_57fd_4cd5_99f4_f1fa7ae28520
is encoded by: hsa:57818
type: Species
has only substance units: false
name: G6PC2
boundary condition: true
initial concentration: NaN
is: SBO:0000252
is: E9PAX2
initial amount: NaN
constant: false

metaM gthrd m
is: CHEBI:57925
notes: FORMULA: C10H16N3O6S CHARGE: -1 INCHI: InChI=1S/C10H17N3O6S/c11-5(10(18)19)1-2-7(14)13-6(4-20)9(17)12-3-8(15)16/h5-6,20H,1-4,11H2,(H,12,17)(H,13,14)(H,15,16)(H,18,19)/p-1/t5-,6-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00056 EHMN_ABBREVIATION: C00051
name: glutathionate(1-)
is: SBO:0000247
type: Species
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: HMDB00125
boundary condition: false
constant: false

metaR GLNtm
kinetic law: MODEL1310110001#
fast: false
is: SBO:0000185
name: L-glutamine transport via electroneutral transporter
product: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: NOTES:TV (6/7/2005) Study in rat liver (Soboll, 1991)
is described by: ECO:0000000
reversible: false
type: Reaction

metaR EX estradiol LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: estradiol exchange
type: Reaction

metaM frdp c
is: SBO:0000247
boundary condition: false
initial concentration: 1.0
is: HMDB00961
initial amount: NaN
has only substance units: false
notes: FORMULA: C15H25O7P2 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00362 EHMN_ABBREVIATION: C00448
type: Species
constant: false
name: Farnesyl diphosphate
is: CHEBI:175763
is: C00448

http://identifiers.org/biomodels.db/MODEL1310110001#_682e92a8_74c0_44b0_8192_7b760df0db3a
initial concentration: NaN
has only substance units: false
boundary condition: true
constant: false
type: Species
name: SLC4A5
initial amount: NaN
is: SBO:0000252
is encoded by: hsa:57835

metaR r1579
reversible: true
type: Reaction
product: MODEL1310110001#
fast: false
is described by: ECO:0000000
reactant: MODEL1310110001#
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1
is: SBO:0000185
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:

metaR r1786
type: Reaction
is: SBO:0000185
product: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110001#
reversible: false
reactant: MODEL1310110001#
name: Y+LAT2 Utilized transport
fast: false

http://identifiers.org/biomodels.db/MODEL1310110001#_fdaeba7e_3f66_4f24_ac12_aed9f3302cea
is encoded by: hsa:2879
is: P36969
initial amount: NaN
is: SBO:0000252
name: GPX4
type: Species
constant: false
initial concentration: NaN
has only substance units: false
boundary condition: true

metaR XOL7AH2tm
kinetic law: MODEL1310110001#
is described by: ECO:0000000
type: Reaction
reactant: MODEL1310110001#
fast: false
name: lipid, flip-flop intracellular transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 2 AUTHORS: PMID:12840657 NOTES:cholesterol precursor, transport by "diffusion" -> actually beleived to be flip-flop mechanism (PMID: 12840657). NJ
product: MODEL1310110001#
is: SBO:0000185
reversible: true

metaR FAOXC141C121m
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: fatty acid beta oxidation(C14:1-->C12:1)m
type: Reaction

metaM lys L x
is: CHEBI:32551
initial concentration: 1.0
boundary condition: false
notes: FORMULA: C6H15N2O2 CHARGE: 1 INCHI: InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/p+1/t5-/m0/s1 HEPATONET_1.0_ABBREVIATION: HC00053 EHMN_ABBREVIATION: C00047
constant: false
is: SBO:0000247
type: Species
initial amount: NaN
has only substance units: false
is: HMDB00182
name: L-lysinium(1+)

http://identifiers.org/biomodels.db/MODEL1310110001#_aac6ab66_1e5c_4d2a_ad33_db73733e53da
initial amount: NaN
is: P21399
initial concentration: NaN
is encoded by: hsa:48
constant: false
boundary condition: true
has only substance units: false
is: SBO:0000252
name: ACO1
type: Species

metaR BTNt4i
type: Reaction
name: Biotin uptake (antiport)
product: MODEL1310110001#
notes: GENE_ASSOCIATION: (80704.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14770311,PMID:15623830 NOTES:IT
is described by: ECO:0000269
reactant: MODEL1310110001#
modifier: MODEL1310110001#
is: SBO:0000185
fast: false
reversible: false
kinetic law: MODEL1310110001#

metaR r1578
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110001#
is described by: ECO:0000000
product: MODEL1310110001#
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
reactant: MODEL1310110001#
reversible: true
name: Amino Acid-Polyamine-Organocation (APC) TCDB:2.A.3.8.1

metaR EX spc hs LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: sphingosylphosphorylcholine (homo sapiens) exchange
type: Reaction

metaM apoC m
has only substance units: false
notes: FORMULA: XH CHARGE: 0
boundary condition: false
is: SBO:0000247
initial concentration: 1.0
initial amount: NaN
constant: false
type: Species
is: CHEBI:32551
name: Apocarboxlase (no lys residue)
is: HMDB00182

metaR r1787
reversible: false
reactant: MODEL1310110001#
fast: false
is described by: ECO:0000000
notes: GENE_ASSOCIATION: (9057.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 0 AUTHORS: PMID:14770309,PMID:14770310 NOTES:
modifier: MODEL1310110001#
name: Y+LAT2 Utilized transport
is: SBO:0000185
product: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#

metaR RE1573M
product: MODEL1310110001#
reversible: true
reactant: MODEL1310110001#
is: SBO:0000176
notes: GENE_ASSOCIATION: (1632.1) or (10455.1) or (1962.1) SUBSYSTEM: Fatty acid oxidation EC Number: 5.3.3.8 Confidence Level: 0 AUTHORS: PMID:10407780 NOTES:
is version of: http://identifiers.org/ec-code/5.3.3.8
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
fast: false
is version of: http://identifiers.org/ec-code/1.1.1.35
type: Reaction
name: RE1573
is described by: ECO:0000000

metaM 13 cis retn r
has only substance units: false
constant: false
initial amount: NaN
is: HMDB06219
type: Species
is: D00348
initial concentration: 1.0
is: http://identifiers.org/pubchem.compound/7847414
boundary condition: false
is: SBO:0000247
notes: FORMULA: C20H27O2 CHARGE: -1 INCHI: InChI=1/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14- EHMN_ABBREVIATION: CE2952
name: 13-cis-retinoate

metaM dchac e
is: HMDB00626
notes: FORMULA: C24H39O4 CHARGE: -1
is: SBO:0000247
type: Species
constant: false
name: deoxycholic acid
boundary condition: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false

metaM 4hphac e
constant: false
is: CHEBI:48999
initial amount: NaN
is: SBO:0000247
is: HMDB00020
boundary condition: false
has only substance units: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
name: 4-hydroxyphenylacetate
type: Species
initial concentration: 1.0

http://identifiers.org/biomodels.db/MODEL1310110001#_af446fcd_b721_438e_8c93_0dfd4bd15593
initial amount: NaN
has only substance units: false
type: Species
constant: false
is encoded by: hsa:6575
is: B2RBR4
is: SBO:0000252
initial concentration: NaN
boundary condition: true
name: SLC20A2

metaM dhcrm hs c
initial concentration: 1.0
has only substance units: false
initial amount: NaN
is: CHEBI:31488
type: Species
is: SBO:0000247
name: dihydroceramide
boundary condition: false
notes: FORMULA: C18H38NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02158 EHMN_ABBREVIATION: C12126
constant: false

metaR AMANK
notes: GENE_ASSOCIATION: (10020.1) or (55577.1) SUBSYSTEM: Aminosugar metabolism EC Number: 2.7.1.60 Confidence Level: 4 AUTHORS: PMID:10330343,PMID:10431835,PMID:11308027 NOTES:JLR - Kegg R02705
kinetic law: MODEL1310110001#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/5.1.3.14
modifier: MODEL1310110001#
name: N-acetyl-D-mannosamine kinase
is described by: ECO:0000269
reactant: MODEL1310110001#
reversible: false
product: MODEL1310110001#
type: Reaction
is version of: http://identifiers.org/ec-code/2.7.1.59
fast: false

metaR PSYTCHe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000176
fast: false
reversible: false
name: binding of psyllium with taurocholate in the intestinal lumen, reducing serum cholsterol levels.
type: Reaction

metaR GLXtp
kinetic law: MODEL1310110001#
is: SBO:0000185
is described by: ECO:0000000
type: Reaction
reversible: true
name: glyoxylate transport, peroxisomal
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: PMID:15240345 NOTES:NCD
product: MODEL1310110001#
reactant: MODEL1310110001#
fast: false

metaM ac m
notes: FORMULA: C2H3O2 CHARGE: -1 INCHI: InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1 HEPATONET_1.0_ABBREVIATION: HC00042 EHMN_ABBREVIATION: C00033
type: Species
constant: false
initial amount: NaN
initial concentration: 1.0
has only substance units: false
is: CHEBI:30089
name: acetate
is: HMDB00042
is: SBO:0000247
boundary condition: false

metaM crm hs r
is: CHEBI:52639
name: N-acylsphingosine
notes: FORMULA: C18H36NO2FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC01990 EHMN_ABBREVIATION: C00195
type: Species
constant: false
has only substance units: false
initial amount: NaN
is: SBO:0000247
initial concentration: 1.0
boundary condition: false

metaR SLDx
notes: GENE_ASSOCIATION: (4190.1) or (130752.1) SUBSYSTEM: Methionine and cysteine metabolism EC Number: 1.1.1.272 Confidence Level: 2 AUTHORS: PMID:15758220,PMID:3346220 NOTES:AMF EC: 1.1.1.272
fast: false
reversible: true
is version of: http://identifiers.org/ec-code/1.1.1.37
name: L-sulfolactate dehydrogenase (NAD+)
modifier: MODEL1310110001#
kinetic law: MODEL1310110001#
is described by: ECO:0000304
product: MODEL1310110001#
type: Reaction
is: SBO:0000176
reactant: MODEL1310110001#

metaR NH4tp
is described by: ECO:0000000
name: ammonia peroxisomal transport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, peroxisomal EC Number: Confidence Level: 1 AUTHORS: NOTES:NCD
reactant: MODEL1310110001#
fast: false
reversible: true
product: MODEL1310110001#
type: Reaction
kinetic law: MODEL1310110001#
is: SBO:0000185

metaR DGSNt
kinetic law: MODEL1310110001#
is: SBO:0000185
reversible: true
is described by: ECO:0000000
name: deoyguanosine transport via diffusion
type: Reaction
fast: false
product: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 2 AUTHORS: PMID:10899995 NOTES:

metaM CE2420 m
is: CHEBI:28387
type: Species
boundary condition: false
initial concentration: 1.0
initial amount: NaN
constant: false
notes: FORMULA: C33H52N7O18P3S CHARGE: -4 INCHI: InChI=1/C33H56N7O18P3S/c1-4-5-6-7-8-9-10-11-21(41)16-24(43)62-15-14-35-23(42)12-13-36-31(46)28(45)33(2,3)18-55-61(52,53)58-60(50,51)54-17-22-27(57-59(47,48)49)26(44)32(56-22)40-20-39-25-29(34)37-19-38-30(25)40/h8-9,19-22,26-28,32,41,44-45H,4-7,10-18H2,1-3H3,(H,35,42)(H,36,46)(H,50,51)(H,52,53)(H2,34,37,38)(H2,47,48,49)/p-4/b9-8-/t21-,22-,26+,27+,28u,32-/m0/s1 EHMN_ABBREVIATION: CE2420
is: HMDB11123
is: SBO:0000247
name: (3S)-3-hydroxydodec-cis-6-enoyl-CoA
has only substance units: false

metaR EX ser L LPAREN e RPAREN
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: Exchange/demand reaction EC Number: Confidence Level: 1 AUTHORS: NOTES:
is described by: ECO:0000000
is: SBO:0000176
fast: false
reversible: true
name: exchange reaction for L-serine
type: Reaction

metaM icit m
type: Species
is: CHEBI:16087
is: HMDB00193
initial amount: NaN
boundary condition: false
name: Isocitrate
has only substance units: false
notes: FORMULA: C6H5O7 CHARGE: -3 HEPATONET_1.0_ABBREVIATION: HC00266 EHMN_ABBREVIATION: C00311
is: SBO:0000247
constant: false
is: C00311
initial concentration: 1.0

metaR TIGCRNe
kinetic law: MODEL1310110001#
product: MODEL1310110001#
reactant: MODEL1310110001#
is described by: ECO:0000134
is: SBO:0000185
fast: false
reversible: false
name: transport of tiglyl carnitine into the extra cellular fluid
type: Reaction

metaM galgluside hs c
is: SBO:0000247
is: HMDB06535
initial concentration: 1.0
boundary condition: false
constant: false
type: Species
has only substance units: false
initial amount: NaN
name: galactosyl glucosyl ceramide
notes: FORMULA: C30H56NO12FULLRCO CHARGE: 0 HEPATONET_1.0_ABBREVIATION: HC02162

metaR FUMm
is described by: ECO:0000134
name: fumarase, mitochondrial
modifier: MODEL1310110001#
reversible: true
fast: false
product: MODEL1310110001#
kinetic law: MODEL1310110001#
notes: GENE_ASSOCIATION: (2271.1) SUBSYSTEM: Citric acid cycle EC Number: 4.2.1.2 Confidence Level: 0 AUTHORS: PMID:16774737,PMID:17111171,PMID:17111172 NOTES:IF. Biochemical
reactant: MODEL1310110001#
is: SBO:0000176
is version of: http://identifiers.org/ec-code/4.2.1.2
type: Reaction

http://identifiers.org/biomodels.db/MODEL1310110001#_e0fa4bd5_8798_46c0_aae2_9b916777bc01
has only substance units: false
constant: false
initial amount: NaN
is encoded by: hsa:10195
is: Q92685
initial concentration: NaN
is: SBO:0000252
name: ALG3
type: Species
boundary condition: true

http://identifiers.org/biomodels.db/MODEL1310110001#_2e6d4b6a_ea41_43c8_a2f9_0ab8ed9d035a
is: SBO:0000252
initial concentration: NaN
boundary condition: true
initial amount: NaN
is: P13686
type: Species
has only substance units: false
name: ACP5
is encoded by: hsa:54
constant: false

metaM cs a deg1 l
initial concentration: 1.0
constant: false
initial amount: NaN
notes: FORMULA: C45H68N2O43S2 CHARGE: -4
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1
type: Species
is: SBO:0000247
is: CHEBI:57455
has only substance units: false
boundary condition: false
is: HMDB01354

http://identifiers.org/biomodels.db/MODEL1310110001#_d8ebaff9_b955_4963_a7bb_2fda7e3cccea
boundary condition: true
constant: false
type: Species
is encoded by: hsa:509
is: Q6I9V2
initial amount: NaN
initial concentration: NaN
name: ATP5C1
has only substance units: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_86335480_7850_485e_89e2_983adc4b4788
is: P09917
is: SBO:0000252
name: ALOX5
boundary condition: true
initial concentration: NaN
is encoded by: hsa:240
has only substance units: false
initial amount: NaN
type: Species
constant: false

metaM hs deg23 l
boundary condition: false
initial concentration: 1.0
notes: FORMULA: C31H49NO29S CHARGE: -2
is: CHEBI:21338
initial amount: NaN
is: HMDB02704
constant: false
name: GlcNAc(3S)-alpha-1,4-GlcA-beta-1,3-Gal-beta-1,3-Gal-beta-1,4-Xylose
type: Species
has only substance units: false
is: SBO:0000247

metaR GLNtN1
kinetic law: MODEL1310110001#
is described by: ECO:0000269
fast: false
is: SBO:0000185
reversible: true
notes: GENE_ASSOCIATION: (92745.1) or (10991.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:10823827,PMID:12845534 NOTES:SAB based om PMID 10823827
reactant: MODEL1310110001#
type: Reaction
name: Glutamine transport (Na, H coupled)
modifier: MODEL1310110001#
product: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_7737c448_57e3_4402_83b7_5882fdcdb80f
initial amount: NaN
initial concentration: NaN
is: SBO:0000252
type: Species
is encoded by: hsa:109
name: ADCY3
boundary condition: true
has only substance units: false
is: B3KT86
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_9e7d8c43_dd79_40f2_b000_736275bfe0e9
initial amount: NaN
name: TBXAS1
is: Q53F23
has only substance units: false
initial concentration: NaN
is encoded by: hsa:6916
type: Species
boundary condition: true
constant: false
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_7cdec86f_0f0d_46ce_9512_b29397fd57e6
is: Q99424
has only substance units: false
name: ACOX2
initial amount: NaN
boundary condition: true
initial concentration: NaN
constant: false
type: Species
is encoded by: hsa:8309
is: SBO:0000252

http://identifiers.org/biomodels.db/MODEL1310110001#_8c4fcda1_9fdb_4917_bada_2822489ae45e
name: LPGAT1
is encoded by: hsa:9926
initial concentration: NaN
has only substance units: false
is: Q92604
type: Species
boundary condition: true
is: SBO:0000252
constant: false
initial amount: NaN

metaR VLCS2r
product: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (11001.1) SUBSYSTEM: Bile acid synthesis EC Number: 6.2.1.7 Confidence Level: 2 AUTHORS: NOTES:from uniprot and lit - see human recon lit refs divalent cation requirement - unclear which one, reaction inhibited in the presence of EDTA (may just be MgATP or MgATP) - see Kelley and Vessey Biochimica et Biophysica Acta (1994) 1209: 51-55 temporarily will have H+ balance reaction NJ
is: SBO:0000176
reversible: false
modifier: MODEL1310110001#
is version of: http://identifiers.org/ec-code/6.2.1.3
type: Reaction
fast: false
kinetic law: MODEL1310110001#
name: Very-long-chain-fatty-acid-CoA ligase
is described by: ECO:0000304

http://identifiers.org/biomodels.db/MODEL1310110001#_6972403e_a180_4eae_b47c_157e4699914d
boundary condition: true
name: CTPS2
is encoded by: hsa:56474
is: Q9NRF8
is: SBO:0000252
initial concentration: NaN
has only substance units: false
type: Species
initial amount: NaN
constant: false

http://identifiers.org/biomodels.db/MODEL1310110001#_116b1a87_63e6_4ad8_a288_7be984c27023
constant: false
boundary condition: true
initial concentration: NaN
is encoded by: hsa:AI697028
has only substance units: false
type: Species
name: _AI697028_1_e
initial amount: NaN
is: SBO:0000252

metaM 4hphac c
has only substance units: false
notes: FORMULA: C8H7O3 CHARGE: -1 INCHI: InChI=1S/C8H8O3/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4,9H,5H2,(H,10,11)/p-1 EHMN_ABBREVIATION: C00642
is: SBO:0000247
type: Species
initial amount: NaN
is: HMDB00020
name: 4-hydroxyphenylacetate
initial concentration: 1.0
boundary condition: false
is: CHEBI:48999
constant: false

metaR r0801
kinetic law: MODEL1310110001#
is version of: http://identifiers.org/ec-code/1.2.1.5
is described by: ECO:0000000
is: SBO:0000185
fast: false
reversible: true
notes: GENE_ASSOCIATION: (220.1) or (218.1) or (221.1) or (222.1) or (U37519.1) SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:11078702 NOTES:
name: Mitochondrial Carrier (MC) TCDB:2.A.29.21.1
modifier: MODEL1310110001#
product: MODEL1310110001#
type: Reaction
reactant: MODEL1310110001#

metaR r0913
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, mitochondrial EC Number: Confidence Level: 0 AUTHORS: PMID:14598172,PMID:16919238,PMID:17173541,PMID:18406340,PMID:8132483 NOTES:
type: Reaction
is: SBO:0000185
kinetic law: MODEL1310110001#
reversible: true
name: Mitochondrial Carrier (MC) TCDB:2.A.29.7.2
is described by: ECO:0000000
reactant: MODEL1310110001#
product: MODEL1310110001#

metaM cspg e e
initial amount: NaN
is: HMDB00630
constant: false
boundary condition: false
initial concentration: 1.0
type: Species
notes: FORMULA: C45H63N2O54S6X CHARGE: -8
is: CHEBI:16040
name: chondroitin sulfate E (GalNAc4,6diS-GlcA) proteoglycan
is: SBO:0000247
has only substance units: false

metaR G12MT1 U
kinetic law: MODEL1310110001#
reactant: MODEL1310110001#
product: MODEL1310110001#
notes: GENE_ASSOCIATION: SUBSYSTEM: N-glycan synthesis EC Number: 2.4.1.131 Confidence Level: 0 AUTHORS: NOTES:
name: Glycolipid 1,2-alpha-D-mannosyltransferase (uterus)
reversible: false
is: SBO:0000176
fast: false
is described by: ECO:0000000
type: Reaction

metaR ALAR
reversible: true
notes: GENE_ASSOCIATION: (11212.1) SUBSYSTEM: Alanine and aspartate metabolism EC Number: 5.1.1.1 Confidence Level: 1 AUTHORS: NOTES:
reactant: MODEL1310110001#
is described by: ECO:0000212
is: SBO:0000176
kinetic law: MODEL1310110001#
type: Reaction
modifier: MODEL1310110001#
name: alanine racemase
fast: false
product: MODEL1310110001#

metaR DHCR71r
name: 7-dehydrocholesterol reductase
is version of: http://identifiers.org/ec-code/1.3.1.21
product: MODEL1310110001#
is: SBO:0000176
is described by: ECO:0000134
reversible: false
type: Reaction
kinetic law: MODEL1310110001#
modifier: MODEL1310110001#
reactant: MODEL1310110001#
notes: GENE_ASSOCIATION: (1717.1) SUBSYSTEM: Cholesterol metabolism EC Number: 1.3.1.21 Confidence Level: 4 AUTHORS: PMID:9465114 NOTES:lanosterol -> cholesterol pathway see paper refs Moebius et al PNAS 95:1899-1902 - check/re-check lit for more specific details (NADPH known to be cofactor - also NADH?, possibly rev?) NJ
fast: false

metaR CYStec
type: Reaction
is described by: ECO:0000269
kinetic law: MODEL1310110001#
product: MODEL1310110001#
is: SBO:0000185
name: L-cysteine transport via diffusion (extracellular to cytosol)
fast: false
reversible: true
notes: GENE_ASSOCIATION: (124935.1) SUBSYSTEM: Transport, extracellular EC Number: Confidence Level: 4 AUTHORS: PMID:14624363,PMID:15659399 NOTES:SAB
reactant: MODEL1310110001#
modifier: MODEL1310110001#

http://identifiers.org/biomodels.db/MODEL1310110001#_4c7e470a_cfba_4840_b9f2_f7564abfe46f
boundary condition: true
initial concentration: NaN
type: Species
name: GALK1
constant: false
is: SBO:0000252
is: P51570
is encoded by: hsa:2584
initial amount: NaN
has only substance units: false